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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ASXL2-ITSN2 (FusionGDB2 ID:7310)

Fusion Gene Summary for ASXL2-ITSN2

check button Fusion gene summary
Fusion gene informationFusion gene name: ASXL2-ITSN2
Fusion gene ID: 7310
HgeneTgene
Gene symbol

ASXL2

ITSN2

Gene ID

55252

50618

Gene nameASXL transcriptional regulator 2intersectin 2
SynonymsASXH2|SHAPNSPRO2015|SH3D1B|SH3P18|SWA|SWAP
Cytomap

2p23.3

2p23.3

Type of geneprotein-codingprotein-coding
Descriptionputative Polycomb group protein ASXL2additional sex combs like 2, transcriptional regulatoradditional sex combs-like protein 2polycomb group protein ASXH2intersectin-2SH3 domain-containing protein 1BSH3P18-like WASP-associated protein
Modification date2020031320200313
UniProtAcc

Q76L83

Q9NZM3

Ensembl transtripts involved in fusion geneENST00000336112, ENST00000435504, 
ENST00000272341, ENST00000497092, 
ENST00000404843, 		ENST00000407704, 
ENST00000355123, ENST00000361999, 
ENST00000406921, 
Fusion gene scores* DoF score18 X 11 X 10=19809 X 15 X 5=675
# samples 2415
** MAII scorelog2(24/1980*10)=-3.04439411935845
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/675*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ASXL2 [Title/Abstract] AND ITSN2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointASXL2(26022254)-ITSN2(24538093), # samples:1
Anticipated loss of major functional domain due to fusion event.ASXL2-ITSN2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
ASXL2-ITSN2 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
ASXL2-ITSN2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneASXL2

GO:0035360

positive regulation of peroxisome proliferator activated receptor signaling pathway

21047783

HgeneASXL2

GO:0045600

positive regulation of fat cell differentiation

21047783

HgeneASXL2

GO:0045944

positive regulation of transcription by RNA polymerase II

21047783

TgeneITSN2

GO:1903861

positive regulation of dendrite extension

23999003


check buttonFusion gene breakpoints across ASXL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ITSN2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-D8-A145-01AASXL2chr2

26022254

-ITSN2chr2

24538093

-


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Fusion Gene ORF analysis for ASXL2-ITSN2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000336112ENST00000407704ASXL2chr2

26022254

-ITSN2chr2

24538093

-
5CDS-5UTRENST00000435504ENST00000407704ASXL2chr2

26022254

-ITSN2chr2

24538093

-
5UTR-3CDSENST00000272341ENST00000355123ASXL2chr2

26022254

-ITSN2chr2

24538093

-
5UTR-3CDSENST00000272341ENST00000361999ASXL2chr2

26022254

-ITSN2chr2

24538093

-
5UTR-3CDSENST00000272341ENST00000406921ASXL2chr2

26022254

-ITSN2chr2

24538093

-
5UTR-3CDSENST00000497092ENST00000355123ASXL2chr2

26022254

-ITSN2chr2

24538093

-
5UTR-3CDSENST00000497092ENST00000361999ASXL2chr2

26022254

-ITSN2chr2

24538093

-
5UTR-3CDSENST00000497092ENST00000406921ASXL2chr2

26022254

-ITSN2chr2

24538093

-
5UTR-5UTRENST00000272341ENST00000407704ASXL2chr2

26022254

-ITSN2chr2

24538093

-
5UTR-5UTRENST00000497092ENST00000407704ASXL2chr2

26022254

-ITSN2chr2

24538093

-
Frame-shiftENST00000336112ENST00000355123ASXL2chr2

26022254

-ITSN2chr2

24538093

-
Frame-shiftENST00000336112ENST00000361999ASXL2chr2

26022254

-ITSN2chr2

24538093

-
Frame-shiftENST00000336112ENST00000406921ASXL2chr2

26022254

-ITSN2chr2

24538093

-
In-frameENST00000435504ENST00000355123ASXL2chr2

26022254

-ITSN2chr2

24538093

-
In-frameENST00000435504ENST00000361999ASXL2chr2

26022254

-ITSN2chr2

24538093

-
In-frameENST00000435504ENST00000406921ASXL2chr2

26022254

-ITSN2chr2

24538093

-
intron-3CDSENST00000404843ENST00000355123ASXL2chr2

26022254

-ITSN2chr2

24538093

-
intron-3CDSENST00000404843ENST00000361999ASXL2chr2

26022254

-ITSN2chr2

24538093

-
intron-3CDSENST00000404843ENST00000406921ASXL2chr2

26022254

-ITSN2chr2

24538093

-
intron-5UTRENST00000404843ENST00000407704ASXL2chr2

26022254

-ITSN2chr2

24538093

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000435504ASXL2chr226022254-ENST00000361999ITSN2chr224538093-644169715356781841
ENST00000435504ASXL2chr226022254-ENST00000355123ITSN2chr224538093-652269715357591868
ENST00000435504ASXL2chr226022254-ENST00000406921ITSN2chr224538093-498669715344151420

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000435504ENST00000361999ASXL2chr226022254-ITSN2chr224538093-0.0009266280.9990734
ENST00000435504ENST00000355123ASXL2chr226022254-ITSN2chr224538093-0.0008586020.99914134
ENST00000435504ENST00000406921ASXL2chr226022254-ITSN2chr224538093-0.0022113330.99778867

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Fusion Genomic Features for ASXL2-ITSN2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ASXL2-ITSN2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:26022254/chr2:24538093)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ASXL2

Q76L83

ITSN2

Q9NZM3

FUNCTION: Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3. {ECO:0000250, ECO:0000269|PubMed:21047783}.FUNCTION: Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:23999003}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneASXL2chr2:26022254chr2:24538093ENST00000435504-51311_861341436.0DomainHTH HARE-type
TgeneITSN2chr2:26022254chr2:24538093ENST0000035512314067_79101698.0Calcium bindingOntology_term=ECO:0000255
TgeneITSN2chr2:26022254chr2:24538093ENST0000036199913967_79101671.0Calcium bindingOntology_term=ECO:0000255
TgeneITSN2chr2:26022254chr2:24538093ENST0000040692113067_79101250.0Calcium bindingOntology_term=ECO:0000255
TgeneITSN2chr2:26022254chr2:24538093ENST00000355123140361_756101698.0Coiled coilOntology_term=ECO:0000255
TgeneITSN2chr2:26022254chr2:24538093ENST00000361999139361_756101671.0Coiled coilOntology_term=ECO:0000255
TgeneITSN2chr2:26022254chr2:24538093ENST00000406921130361_756101250.0Coiled coilOntology_term=ECO:0000255
TgeneITSN2chr2:26022254chr2:24538093ENST000003551231401053_1117101698.0DomainSH3 4
TgeneITSN2chr2:26022254chr2:24538093ENST000003551231401127_1186101698.0DomainSH3 5
TgeneITSN2chr2:26022254chr2:24538093ENST000003551231401209_1395101698.0DomainDH
TgeneITSN2chr2:26022254chr2:24538093ENST000003551231401434_1544101698.0DomainPH
TgeneITSN2chr2:26022254chr2:24538093ENST000003551231401552_1668101698.0DomainC2
TgeneITSN2chr2:26022254chr2:24538093ENST0000035512314022_110101698.0DomainEH 1
TgeneITSN2chr2:26022254chr2:24538093ENST00000355123140244_333101698.0DomainEH 2
TgeneITSN2chr2:26022254chr2:24538093ENST0000035512314054_89101698.0DomainEF-hand
TgeneITSN2chr2:26022254chr2:24538093ENST00000355123140757_818101698.0DomainSH3 1
TgeneITSN2chr2:26022254chr2:24538093ENST00000355123140898_956101698.0DomainSH3 2
TgeneITSN2chr2:26022254chr2:24538093ENST00000355123140981_1039101698.0DomainSH3 3
TgeneITSN2chr2:26022254chr2:24538093ENST000003619991391053_1117101671.0DomainSH3 4
TgeneITSN2chr2:26022254chr2:24538093ENST000003619991391127_1186101671.0DomainSH3 5
TgeneITSN2chr2:26022254chr2:24538093ENST000003619991391209_1395101671.0DomainDH
TgeneITSN2chr2:26022254chr2:24538093ENST000003619991391434_1544101671.0DomainPH
TgeneITSN2chr2:26022254chr2:24538093ENST000003619991391552_1668101671.0DomainC2
TgeneITSN2chr2:26022254chr2:24538093ENST0000036199913922_110101671.0DomainEH 1
TgeneITSN2chr2:26022254chr2:24538093ENST00000361999139244_333101671.0DomainEH 2
TgeneITSN2chr2:26022254chr2:24538093ENST0000036199913954_89101671.0DomainEF-hand
TgeneITSN2chr2:26022254chr2:24538093ENST00000361999139757_818101671.0DomainSH3 1
TgeneITSN2chr2:26022254chr2:24538093ENST00000361999139898_956101671.0DomainSH3 2
TgeneITSN2chr2:26022254chr2:24538093ENST00000361999139981_1039101671.0DomainSH3 3
TgeneITSN2chr2:26022254chr2:24538093ENST000004069211301053_1117101250.0DomainSH3 4
TgeneITSN2chr2:26022254chr2:24538093ENST000004069211301127_1186101250.0DomainSH3 5
TgeneITSN2chr2:26022254chr2:24538093ENST000004069211301209_1395101250.0DomainDH
TgeneITSN2chr2:26022254chr2:24538093ENST000004069211301434_1544101250.0DomainPH
TgeneITSN2chr2:26022254chr2:24538093ENST000004069211301552_1668101250.0DomainC2
TgeneITSN2chr2:26022254chr2:24538093ENST0000040692113022_110101250.0DomainEH 1
TgeneITSN2chr2:26022254chr2:24538093ENST00000406921130244_333101250.0DomainEH 2
TgeneITSN2chr2:26022254chr2:24538093ENST0000040692113054_89101250.0DomainEF-hand
TgeneITSN2chr2:26022254chr2:24538093ENST00000406921130757_818101250.0DomainSH3 1
TgeneITSN2chr2:26022254chr2:24538093ENST00000406921130898_956101250.0DomainSH3 2
TgeneITSN2chr2:26022254chr2:24538093ENST00000406921130981_1039101250.0DomainSH3 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneASXL2chr2:26022254chr2:24538093ENST00000272341-4131173_11760919.0Compositional biasNote=Poly-Ser
HgeneASXL2chr2:26022254chr2:24538093ENST00000272341-413303_3070919.0Compositional biasNote=Poly-Leu
HgeneASXL2chr2:26022254chr2:24538093ENST00000272341-413654_6840919.0Compositional biasNote=Ala-rich
HgeneASXL2chr2:26022254chr2:24538093ENST00000272341-413687_7390919.0Compositional biasNote=Gly-rich
HgeneASXL2chr2:26022254chr2:24538093ENST00000272341-41395_2350919.0Compositional biasNote=Ser-rich
HgeneASXL2chr2:26022254chr2:24538093ENST00000404843-1101173_11760919.0Compositional biasNote=Poly-Ser
HgeneASXL2chr2:26022254chr2:24538093ENST00000404843-110303_3070919.0Compositional biasNote=Poly-Leu
HgeneASXL2chr2:26022254chr2:24538093ENST00000404843-110654_6840919.0Compositional biasNote=Ala-rich
HgeneASXL2chr2:26022254chr2:24538093ENST00000404843-110687_7390919.0Compositional biasNote=Gly-rich
HgeneASXL2chr2:26022254chr2:24538093ENST00000404843-11095_2350919.0Compositional biasNote=Ser-rich
HgeneASXL2chr2:26022254chr2:24538093ENST00000435504-5131173_11761341436.0Compositional biasNote=Poly-Ser
HgeneASXL2chr2:26022254chr2:24538093ENST00000435504-513303_3071341436.0Compositional biasNote=Poly-Leu
HgeneASXL2chr2:26022254chr2:24538093ENST00000435504-513654_6841341436.0Compositional biasNote=Ala-rich
HgeneASXL2chr2:26022254chr2:24538093ENST00000435504-513687_7391341436.0Compositional biasNote=Gly-rich
HgeneASXL2chr2:26022254chr2:24538093ENST00000435504-51395_2351341436.0Compositional biasNote=Ser-rich
HgeneASXL2chr2:26022254chr2:24538093ENST00000272341-41311_860919.0DomainHTH HARE-type
HgeneASXL2chr2:26022254chr2:24538093ENST00000272341-413274_3830919.0DomainDEUBAD
HgeneASXL2chr2:26022254chr2:24538093ENST00000404843-11011_860919.0DomainHTH HARE-type
HgeneASXL2chr2:26022254chr2:24538093ENST00000404843-110274_3830919.0DomainDEUBAD
HgeneASXL2chr2:26022254chr2:24538093ENST00000435504-513274_3831341436.0DomainDEUBAD
HgeneASXL2chr2:26022254chr2:24538093ENST00000272341-413174_1780919.0MotifNuclear localization signal
HgeneASXL2chr2:26022254chr2:24538093ENST00000272341-413887_8910919.0MotifNote=LXXLL motif 2
HgeneASXL2chr2:26022254chr2:24538093ENST00000404843-110174_1780919.0MotifNuclear localization signal
HgeneASXL2chr2:26022254chr2:24538093ENST00000404843-110887_8910919.0MotifNote=LXXLL motif 2
HgeneASXL2chr2:26022254chr2:24538093ENST00000435504-513174_1781341436.0MotifNuclear localization signal
HgeneASXL2chr2:26022254chr2:24538093ENST00000435504-513887_8911341436.0MotifNote=LXXLL motif 2
HgeneASXL2chr2:26022254chr2:24538093ENST00000272341-4131397_14340919.0Zinc fingerNote=PHD-type%3B atypical
HgeneASXL2chr2:26022254chr2:24538093ENST00000404843-1101397_14340919.0Zinc fingerNote=PHD-type%3B atypical
HgeneASXL2chr2:26022254chr2:24538093ENST00000435504-5131397_14341341436.0Zinc fingerNote=PHD-type%3B atypical


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Fusion Gene Sequence for ASXL2-ITSN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>7310_7310_1_ASXL2-ITSN2_ASXL2_chr2_26022254_ENST00000435504_ITSN2_chr2_24538093_ENST00000355123_length(transcript)=6522nt_BP=697nt
ACAGTAGTGACGGCCGCGCGGGAGCGGTCACATGACCGTAGCGGCAGCCTGTACAGTAAGAACCCAATATGGCAGCGGCGGTAGCAGTGG
CAACGGCAGCAAGAGGACCGGCCGCCCCATAGACCCCCCCGCGCACCACCCCCGCCGCTTCCTCTGCTTGGGTGCCCCCCCGGTCTGACT
TCCCTTTTCTCCCACCTTTCCCGGCACCGCGGGAAAAGCAGCGCAGGGCAGAGCAGGCAGGGAGGGCGGCCGGAGCCCGGACACGGGAGC
CTCCCAGTCAGTTCAAGACCCGACATGAGGGAAAAGGGACGTAGGAAGAAGGGCAGGACCTGGGCGGAGGCCGCCAAGACGGTCTTAGAA
AAATACCCCAATACACCCATGAGTCATAAAGAAATTCTTCAAGTTATCCAGAGAGAAGGACTAAAAGAAATCAGAAGTGGGACTTCTCCT
CTTGCATGCCTGAATGCAATGCTTCACACAAACTCCAGAGGTGAAGAGGGCATCTTCTATAAGGTTCCAGGTAGAATGGGAGTATATACT
TTGAAGAAAGATGTGCCGGATGGGGTGAAAGAGCTGTCAGAAGGTTCAGAAGAAAGCAGTGATGGTCAGTCAGATTCCCAGAGTTCTGAG
AACAGCAGCAGCAGCAGTGATGGTGGCAGCAACAAGGAGGGAAAAAAGAGCAGGTGGAAAAGGAAAGGAGGGCCAAACATGTGGGCTATT
ACCTCTGAAGAACGTACTAAGCATGACAGGCAGTTTGATAACCTCAAACCTTCAGGAGGTTACATAACAGGTGATCAAGCACGTAATTTT
TTCCTACAATCAGGTCTGCCGGCCCCTGTTTTAGCTGAAATATGGGCTTTATCAGACCTAAACAAGGATGGGAAGATGGATCAGCAAGAG
TTCTCCATAGCTATGAAACTCATCAAACTGAAGCTTCAAGGCCAACAGTTGCCTGTGGTTCTCCCTCCTATTATGAAGCAACCCCCTATG
TTTTCTCCATTAATTTCTGCTCGTTTTGGAATGGGAAGCATGCCCAATCTGTCCATTCCTCAGCCATTGCCTCCAGCTGCACCTATAACA
TCATTGTCTTCTGCGACTTCAGGGACCAACCTTCCTCCCTTAATGATGCCCACTCCCCTAGTGCCTTCTGTTAGCACATCATCATTACCA
AATGGAACCGCCAGTCTCATTCAGCCTTTACCCATTCCTTATTCTTCTTCAACATTGCCTCATGGGTCATCTTATAGTCTGATGATGGGA
GGATTTGGAGGTGCTAGTATACAGAAAGCGCAGTCTCTGATTGATTTAGGATCTAGTAGCTCAACTTCCTCGACTGCTTCACTCTCAGGG
AACTCACCCAAGACTGGGACCTCAGAGTGGGCAGTTCCTCAGCCTACAAGATTAAAATATCGGCAAAAATTTAATACTCTTGACAAAAGT
ATGAGTGGATATCTCTCAGGTTTTCAAGCTAGAAATGCCCTTCTTCAGTCAAATCTTTCTCAAACTCAGCTGGCTACTATTTGGACTCTG
GCTGACGTTGATGGTGATGGACAGCTAAAAGCAGAAGAGTTTATTCTTGCAATGCACCTTACTGACATGGCCAAAGCTGGACAGCCATTA
CCACTGACTTTACCTCCTGAGCTTGTTCCTCCATCTTTCAGAGGAGGAAAGCAAATTGATTCCATTAATGGAACTCTGCCTTCATATCAG
AAAATGCAAGAAGAGGAGCCTCAGAAGAAATTACCAGTTACTTTTGAGGACAAACGGAAAGCCAACTATGAGCGAGGGAACATGGAGCTG
GAAAAGCGACGCCAAGCCTTGATGGAGCAGCAACAAAGGGAGGCAGAACGTAAAGCCCAGAAAGAAAAGGAAGAGTGGGAACGAAAACAG
AGAGAATTACAAGAACAAGAATGGAAGAAACAACTTGAATTAGAAAAACGCTTAGAGAAGCAACGGGAATTGGAGAGACAACGAGAGGAA
GAAAGGAGAAAAGACATAGAAAGACGAGAGGCAGCAAAACAGGAACTTGAACGACAACGTCGCTTAGAATGGGAGAGAATTCGGCGACAG
GAGCTTCTCAATCAAAAGAATAGAGAACAAGAAGAAATTGTCAGGTTAAACTCTAAAAAGAAGAATCTTCATCTTGAGTTGGAAGCACTG
AATGGCAAACATCAGCAGATCTCAGGCAGACTTCAGGATGTCCGACTCAAAAAGCAAACTCAAAAGACTGAGCTGGAAGTTCTGGATAAG
CAGTGTGACTTGGAAATTATGGAAATCAAGCAACTTCAACAGGAACTTCAGGAATATCAGAATAAGCTTATCTATCTGGTACCTGAGAAG
CAATTATTAAATGAAAGAATTAAAAACATGCAGTTCAGTAACACACCTGATTCAGGGGTCAGTTTACTTCATAAAAAATCATTAGAAAAG
GAAGAATTATGCCAAAGACTTAAAGAACAGTTAGATGCTCTTGAAAAAGAAACTGCATCTAAGCTGTCAGAAATGGATTCTTTTAACAAT
CAACTAAAGTGTGGGAATATGGATGACTCTGTTCTTCAGTGCCTTTTGTCTCTGCTAAGCTGTCTCAACAACCTCTTCCTCTTACTTAAG
GAACTGAGAGAAACCTACAACACACAGCAGTTAGCCCTTGAACAGCTTTATAAGATCAAACGTGACAAGTTGAAGGAAATTGAAAGGAAA
AGATTAGAACTAATGCAGAAAAAGAAACTAGAAGATGAGGCTGCAAGGAAAGCAAAGCAAGGAAAAGAAAACTTATGGAAAGAAAATCTT
AGAAAGGAGGAAGAAGAAAAACAAAAGCGACTCCAGGAAGAAAAAACACAAGAAAAAATTCAAGAAGAGGAACGGAAAGCTGAGGAGAAA
CAACGTAAGGATAAGGATACTTTGAAAGCTGAGGAGAAAAAACGTGAGACAGCTAGTGTTTTGGTGAATTATAGAGCATTATACCCCTTT
GAAGCAAGGAACCATGATGAGATGAGTTTTAATTCTGGAGATATAATTCAGGTTGATGAAAAAACCGTAGGAGAACCTGGTTGGCTTTAT
GGTAGTTTTCAAGGAAATTTTGGCTGGTTTCCATGCAATTATGTAGAAAAAATGCCATCAAGTGAAAATGAAAAAGCTGTATCTCCAAAG
AAGGCCTTACTTCCTCCTACAGTTTCTTTATCTGCTACCTCAACTTCCTCTGAACCACTTTCTTCAAATCAACCAGCATCAGTGACTGAT
TATCAAAATGTATCTTTTTCAAACCTAACTGTAAATACATCATGGCAGAAAAAATCAGCCTTCACTCGAACTGTGTCCCCTGGATCTGTA
TCACCTATTCATGGACAGGGACAAGTGGTAGAAAACTTAAAAGCACAGGCCCTTTGTTCCTGGACTGCAAAGAAAGATAACCACTTGAAC
TTCTCAAAACATGACATTATTACTGTCTTGGAGCAGCAAGAAAATTGGTGGTTTGGGGAGGTGCATGGAGGAAGAGGATGGTTTCCCAAA
TCTTATGTCAAGATCATTCCTGGGAGTGAAGTAAAACGGGAAGAACCAGAAGCTTTGTATGCAGCTGTAAATAAGAAACCTACCTCGGCA
GCCTATTCAGTTGGAGAAGAATATATTGCACTTTATCCATATTCAAGTGTGGAACCTGGAGATTTGACTTTCACAGAAGGTGAAGAAATA
TTGGTGACCCAGAAAGATGGAGAGTGGTGGACAGGAAGTATTGGAGATAGAAGTGGAATTTTTCCATCAAACTATGTCAAACCAAAGGAT
CAAGAGAGTTTTGGGAGTGCTAGCAAGTCTGGAGCATCAAATAAAAAACCTGAGATTGCTCAGGTAACTTCAGCATATGTTGCTTCTGGT
TCTGAACAACTTAGCCTTGCACCAGGACAGTTAATATTAATTCTAAAGAAAAATACAAGTGGGTGGTGGCAAGGAGAGTTACAGGCCAGA
GGAAAAAAGCGACAGAAAGGATGGTTTCCTGCCAGTCATGTTAAACTTTTGGGTCCAAGTAGTGAAAGAGCCACACCTGCCTTTCATCCT
GTATGTCAGGTGATTGCTATGTATGACTATGCAGCAAATAATGAAGATGAGCTCAGTTTCTCCAAGGGACAACTCATTAATGTTATGAAC
AAAGATGATCCTGATTGGTGGCAAGGAGAGATCAACGGGGTGACTGGTCTCTTTCCTTCAAACTACGTTAAGATGACGACAGACTCAGAT
CCAAGTCAACAGTGGTGTGCTGATCTGCAAACCCTGGACACAATGCAGCCAATTGAGAGGAAAAGACAGGGCTATATTCATGAGCTGATT
CAGACCGAAGAGCGGTACATGGCTGACCTTCAGCTCGTCGTCGAGGTTTTTCAGAAACGCATGGCAGAGTCAGGCTTTCTCACTGAAGGG
GAGATGGCCCTGATTTTTGTTAACTGGAAGGAGCTCATCATGTCCAACACAAAGCTGCTGAAGGCTTTGCGGGTGCGGAAGAAGACCGGG
GGCGAGAAGATGCCGGTGCAGATGATTGGGGACATCCTGGCCGCTGAGCTGTCCCACATGCAGGCTTACATCAGGTTCTGCAGCTGCCAG
CTTAATGGAGCAGCTCTGTTACAGCAGAAGACAGATGAAGACACAGATTTCAAAGAATTTTTAAAGAAGCTGGCATCTGACCCGCGGTGT
AAAGGAATGCCCCTCTCCAGCTTCCTGCTGAAACCCATGCAGAGGATCACCCGCTACCCACTGCTCATCAGAAGTATTCTGGAGAACACC
CCGGAGAGCCATGCAGACCATTCCTCCCTAAAGCTGGCCCTCGAGCGGGCAGAGGAGCTGTGCTCTCAAGTGAATGAGGGAGTTCGGGAG
AAGGAAAACTCGGACCGACTGGAGTGGATCCAGGCGCACGTGCAGTGTGAAGGCCTCGCGGAGCAACTTATTTTCAACTCTCTCACCAAC
TGCCTGGGGCCCCGGAAGCTCTTACACAGTGGGAAATTATACAAGACCAAGAGCAACAAGGAACTGCACGGATTCCTCTTCAATGACTTC
CTGCTTCTTACCTACATGGTCAAGCAGTTTGCTGTTTCCTCTGGCTCTGAGAAACTTTTCAGCTCGAAGTCCAATGCTCAATTCAAAATG
TATAAAACGCCCATTTTCCTGAATGAAGTCTTGGTGAAACTGCCCACAGACCCTTCCAGCGATGAGCCTGTCTTCCACATTTCCCACATT
GATCGGGTCTACACCCTCCGAACAGACAACATTAATGAGAGGACCGCCTGGGTGCAGAAGATCAAGGCGGCGTCTGAGCAGTACATCGAC
ACCGAGAAGAAGAAGCGTGAGAAAGCTTACCAAGCCCGCTCCCAAAAGACTTCAGGCATTGGGCGCCTGATGGTGCATGTCATTGAAGCT
ACAGAATTAAAAGCCTGCAAACCAAATGGAAAGAGCAACCCATACTGTGAAATCAGCATGGGCTCCCAGAGCTACACCACCAGGACCATC
CAGGACACACTCAATCCCAAGTGGAATTTTAACTGCCAGTTCTTTATTAAGGATCTCTACCAAGACGTGCTGTGTCTCACCCTGTTTGAC
AGAGACCAGTTTTCACCAGATGATTTCCTGGGTCGTACTGAAATTCCAGTGGCAAAAATTCGAACAGAACAGGAAAGCAAAGGCCCTATG
ACCCGCCGACTGCTGCTGCATGAGGTCCCCACCGGGGAGGTCTGGGTCCGTTTTGACCTGCAGCTTTTTGAGCAAAAAACTCTCCTGTAG
GGGTTCTAAAGGACAGCACCAGCGGGACAGCCCACAAGGCTGGGGCTGGAGAATGAGAGACTGCGCTCTCTTGGGGCTGAGGGAGCACCA
TGCAGCTTCACCCCTCACAAAGCCATGCACGCTGGGGGCTCTGTTTTCCTGCACACTAAATAGCTAGCAATCTATGCAAACACCTTTCCC
ATAAAGAAACCAAACCCCATAGTACAGTGCCTTGTCCTAGTGTTCACATGTTCAGCTCTGTTTGTTTAGATGCCAAGGTTTCCATTTTCA
GGGCTATAAAAAGTATTACTTGGAAATGAGGCATCAGACCACCAGATGTTACCGCTCGGTTGAATGTGTCCACCGTGGAGTGGTTTGGTG
ACGCTGTAACCATTCCACGCCAGTGACCTCTGCTGGGTCACAGCCACTCAGGAGGGGAAGGGTCAGGATGAGAGGCTGCAGCCTCGACAC
TTGGCGCGGCCTGATACTGAAATAGCGTCTACTCGTGCACTGAATAAAAACAGAAACTTGATCATTTTATTCCTGATTAGATTTTATCAC
TCTCTGCTAAGACAATATAGTCTGGAGTATAAGTGGGAAAGCTTGATTTAAATACTGTGAACTCTAATAATGTGGAAAATATTTTTCAAC
TTTAATTTTCTGAAGTATAAATTATTTATGTAAATTCATTGTTTTTGCATATTTCTTAGGACATGCATCTTTAAGCTTTATCATTGCCCA

>7310_7310_1_ASXL2-ITSN2_ASXL2_chr2_26022254_ENST00000435504_ITSN2_chr2_24538093_ENST00000355123_length(amino acids)=1868AA_BP=1
MLGCPPGLTSLFSHLSRHRGKSSAGQSRQGGRPEPGHGSLPVSSRPDMREKGRRKKGRTWAEAAKTVLEKYPNTPMSHKEILQVIQREGL
KEIRSGTSPLACLNAMLHTNSRGEEGIFYKVPGRMGVYTLKKDVPDGVKELSEGSEESSDGQSDSQSSENSSSSSDGGSNKEGKKSRWKR
KGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLAEIWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVL
PPIMKQPPMFSPLISARFGMGSMPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPIPYSSSTLPH
GSSYSLMMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAVPQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQ
TQLATIWTLADVDGDGQLKAEEFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLPVTFEDKRKA
NYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRR
LEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQN
KLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSC
LNNLFLLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQ
EEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSS
ENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSPGSVSPIHGQGQVVENLKAQALCSW
TAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGD
LTFTEGEEILVTQKDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSG
WWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSN
YVKMTTDSDPSQQWCADLQTLDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTKLLK
ALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPL
LIRSILENTPESHADHSSLKLALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRKLLHSGKLYKTKSNKE
LHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLVKLPTDPSSDEPVFHISHIDRVYTLRTDNINERTAWVQKI
KAASEQYIDTEKKKREKAYQARSQKTSGIGRLMVHVIEATELKACKPNGKSNPYCEISMGSQSYTTRTIQDTLNPKWNFNCQFFIKDLYQ

--------------------------------------------------------------
>7310_7310_2_ASXL2-ITSN2_ASXL2_chr2_26022254_ENST00000435504_ITSN2_chr2_24538093_ENST00000361999_length(transcript)=6441nt_BP=697nt
ACAGTAGTGACGGCCGCGCGGGAGCGGTCACATGACCGTAGCGGCAGCCTGTACAGTAAGAACCCAATATGGCAGCGGCGGTAGCAGTGG
CAACGGCAGCAAGAGGACCGGCCGCCCCATAGACCCCCCCGCGCACCACCCCCGCCGCTTCCTCTGCTTGGGTGCCCCCCCGGTCTGACT
TCCCTTTTCTCCCACCTTTCCCGGCACCGCGGGAAAAGCAGCGCAGGGCAGAGCAGGCAGGGAGGGCGGCCGGAGCCCGGACACGGGAGC
CTCCCAGTCAGTTCAAGACCCGACATGAGGGAAAAGGGACGTAGGAAGAAGGGCAGGACCTGGGCGGAGGCCGCCAAGACGGTCTTAGAA
AAATACCCCAATACACCCATGAGTCATAAAGAAATTCTTCAAGTTATCCAGAGAGAAGGACTAAAAGAAATCAGAAGTGGGACTTCTCCT
CTTGCATGCCTGAATGCAATGCTTCACACAAACTCCAGAGGTGAAGAGGGCATCTTCTATAAGGTTCCAGGTAGAATGGGAGTATATACT
TTGAAGAAAGATGTGCCGGATGGGGTGAAAGAGCTGTCAGAAGGTTCAGAAGAAAGCAGTGATGGTCAGTCAGATTCCCAGAGTTCTGAG
AACAGCAGCAGCAGCAGTGATGGTGGCAGCAACAAGGAGGGAAAAAAGAGCAGGTGGAAAAGGAAAGGAGGGCCAAACATGTGGGCTATT
ACCTCTGAAGAACGTACTAAGCATGACAGGCAGTTTGATAACCTCAAACCTTCAGGAGGTTACATAACAGGTGATCAAGCACGTAATTTT
TTCCTACAATCAGGTCTGCCGGCCCCTGTTTTAGCTGAAATATGGGCTTTATCAGACCTAAACAAGGATGGGAAGATGGATCAGCAAGAG
TTCTCCATAGCTATGAAACTCATCAAACTGAAGCTTCAAGGCCAACAGTTGCCTGTGGTTCTCCCTCCTATTATGAAGCAACCCCCTATG
TTTTCTCCATTAATTTCTGCTCGTTTTGGAATGGGAAGCATGCCCAATCTGTCCATTCCTCAGCCATTGCCTCCAGCTGCACCTATAACA
TCATTGTCTTCTGCGACTTCAGGGACCAACCTTCCTCCCTTAATGATGCCCACTCCCCTAGTGCCTTCTGTTAGCACATCATCATTACCA
AATGGAACCGCCAGTCTCATTCAGCCTTTACCCATTCCTTATTCTTCTTCAACATTGCCTCATGGGTCATCTTATAGTCTGATGATGGGA
GGATTTGGAGGTGCTAGTATACAGAAAGCGCAGTCTCTGATTGATTTAGGATCTAGTAGCTCAACTTCCTCGACTGCTTCACTCTCAGGG
AACTCACCCAAGACTGGGACCTCAGAGTGGGCAGTTCCTCAGCCTACAAGATTAAAATATCGGCAAAAATTTAATACTCTTGACAAAAGT
ATGAGTGGATATCTCTCAGGTTTTCAAGCTAGAAATGCCCTTCTTCAGTCAAATCTTTCTCAAACTCAGCTGGCTACTATTTGGACTCTG
GCTGACGTTGATGGTGATGGACAGCTAAAAGCAGAAGAGTTTATTCTTGCAATGCACCTTACTGACATGGCCAAAGCTGGACAGCCATTA
CCACTGACTTTACCTCCTGAGCTTGTTCCTCCATCTTTCAGAGGAGGAAAGCAAATTGATTCCATTAATGGAACTCTGCCTTCATATCAG
AAAATGCAAGAAGAGGAGCCTCAGAAGAAATTACCAGTTACTTTTGAGGACAAACGGAAAGCCAACTATGAGCGAGGGAACATGGAGCTG
GAAAAGCGACGCCAAGCCTTGATGGAGCAGCAACAAAGGGAGGCAGAACGTAAAGCCCAGAAAGAAAAGGAAGAGTGGGAACGAAAACAG
AGAGAATTACAAGAACAAGAATGGAAGAAACAACTTGAATTAGAAAAACGCTTAGAGAAGCAACGGGAATTGGAGAGACAACGAGAGGAA
GAAAGGAGAAAAGACATAGAAAGACGAGAGGCAGCAAAACAGGAACTTGAACGACAACGTCGCTTAGAATGGGAGAGAATTCGGCGACAG
GAGCTTCTCAATCAAAAGAATAGAGAACAAGAAGAAATTGTCAGGTTAAACTCTAAAAAGAAGAATCTTCATCTTGAGTTGGAAGCACTG
AATGGCAAACATCAGCAGATCTCAGGCAGACTTCAGGATGTCCGACTCAAAAAGCAAACTCAAAAGACTGAGCTGGAAGTTCTGGATAAG
CAGTGTGACTTGGAAATTATGGAAATCAAGCAACTTCAACAGGAACTTCAGGAATATCAGAATAAGCTTATCTATCTGGTACCTGAGAAG
CAATTATTAAATGAAAGAATTAAAAACATGCAGTTCAGTAACACACCTGATTCAGGGGTCAGTTTACTTCATAAAAAATCATTAGAAAAG
GAAGAATTATGCCAAAGACTTAAAGAACAGTTAGATGCTCTTGAAAAAGAAACTGCATCTAAGCTGTCAGAAATGGATTCTTTTAACAAT
CAACTAAAGGAACTGAGAGAAACCTACAACACACAGCAGTTAGCCCTTGAACAGCTTTATAAGATCAAACGTGACAAGTTGAAGGAAATT
GAAAGGAAAAGATTAGAACTAATGCAGAAAAAGAAACTAGAAGATGAGGCTGCAAGGAAAGCAAAGCAAGGAAAAGAAAACTTATGGAAA
GAAAATCTTAGAAAGGAGGAAGAAGAAAAACAAAAGCGACTCCAGGAAGAAAAAACACAAGAAAAAATTCAAGAAGAGGAACGGAAAGCT
GAGGAGAAACAACGTAAGGATAAGGATACTTTGAAAGCTGAGGAGAAAAAACGTGAGACAGCTAGTGTTTTGGTGAATTATAGAGCATTA
TACCCCTTTGAAGCAAGGAACCATGATGAGATGAGTTTTAATTCTGGAGATATAATTCAGGTTGATGAAAAAACCGTAGGAGAACCTGGT
TGGCTTTATGGTAGTTTTCAAGGAAATTTTGGCTGGTTTCCATGCAATTATGTAGAAAAAATGCCATCAAGTGAAAATGAAAAAGCTGTA
TCTCCAAAGAAGGCCTTACTTCCTCCTACAGTTTCTTTATCTGCTACCTCAACTTCCTCTGAACCACTTTCTTCAAATCAACCAGCATCA
GTGACTGATTATCAAAATGTATCTTTTTCAAACCTAACTGTAAATACATCATGGCAGAAAAAATCAGCCTTCACTCGAACTGTGTCCCCT
GGATCTGTATCACCTATTCATGGACAGGGACAAGTGGTAGAAAACTTAAAAGCACAGGCCCTTTGTTCCTGGACTGCAAAGAAAGATAAC
CACTTGAACTTCTCAAAACATGACATTATTACTGTCTTGGAGCAGCAAGAAAATTGGTGGTTTGGGGAGGTGCATGGAGGAAGAGGATGG
TTTCCCAAATCTTATGTCAAGATCATTCCTGGGAGTGAAGTAAAACGGGAAGAACCAGAAGCTTTGTATGCAGCTGTAAATAAGAAACCT
ACCTCGGCAGCCTATTCAGTTGGAGAAGAATATATTGCACTTTATCCATATTCAAGTGTGGAACCTGGAGATTTGACTTTCACAGAAGGT
GAAGAAATATTGGTGACCCAGAAAGATGGAGAGTGGTGGACAGGAAGTATTGGAGATAGAAGTGGAATTTTTCCATCAAACTATGTCAAA
CCAAAGGATCAAGAGAGTTTTGGGAGTGCTAGCAAGTCTGGAGCATCAAATAAAAAACCTGAGATTGCTCAGGTAACTTCAGCATATGTT
GCTTCTGGTTCTGAACAACTTAGCCTTGCACCAGGACAGTTAATATTAATTCTAAAGAAAAATACAAGTGGGTGGTGGCAAGGAGAGTTA
CAGGCCAGAGGAAAAAAGCGACAGAAAGGATGGTTTCCTGCCAGTCATGTTAAACTTTTGGGTCCAAGTAGTGAAAGAGCCACACCTGCC
TTTCATCCTGTATGTCAGGTGATTGCTATGTATGACTATGCAGCAAATAATGAAGATGAGCTCAGTTTCTCCAAGGGACAACTCATTAAT
GTTATGAACAAAGATGATCCTGATTGGTGGCAAGGAGAGATCAACGGGGTGACTGGTCTCTTTCCTTCAAACTACGTTAAGATGACGACA
GACTCAGATCCAAGTCAACAGTGGTGTGCTGATCTGCAAACCCTGGACACAATGCAGCCAATTGAGAGGAAAAGACAGGGCTATATTCAT
GAGCTGATTCAGACCGAAGAGCGGTACATGGCTGACCTTCAGCTCGTCGTCGAGGTTTTTCAGAAACGCATGGCAGAGTCAGGCTTTCTC
ACTGAAGGGGAGATGGCCCTGATTTTTGTTAACTGGAAGGAGCTCATCATGTCCAACACAAAGCTGCTGAAGGCTTTGCGGGTGCGGAAG
AAGACCGGGGGCGAGAAGATGCCGGTGCAGATGATTGGGGACATCCTGGCCGCTGAGCTGTCCCACATGCAGGCTTACATCAGGTTCTGC
AGCTGCCAGCTTAATGGAGCAGCTCTGTTACAGCAGAAGACAGATGAAGACACAGATTTCAAAGAATTTTTAAAGAAGCTGGCATCTGAC
CCGCGGTGTAAAGGAATGCCCCTCTCCAGCTTCCTGCTGAAACCCATGCAGAGGATCACCCGCTACCCACTGCTCATCAGAAGTATTCTG
GAGAACACCCCGGAGAGCCATGCAGACCATTCCTCCCTAAAGCTGGCCCTCGAGCGGGCAGAGGAGCTGTGCTCTCAAGTGAATGAGGGA
GTTCGGGAGAAGGAAAACTCGGACCGACTGGAGTGGATCCAGGCGCACGTGCAGTGTGAAGGCCTCGCGGAGCAACTTATTTTCAACTCT
CTCACCAACTGCCTGGGGCCCCGGAAGCTCTTACACAGTGGGAAATTATACAAGACCAAGAGCAACAAGGAACTGCACGGATTCCTCTTC
AATGACTTCCTGCTTCTTACCTACATGGTCAAGCAGTTTGCTGTTTCCTCTGGCTCTGAGAAACTTTTCAGCTCGAAGTCCAATGCTCAA
TTCAAAATGTATAAAACGCCCATTTTCCTGAATGAAGTCTTGGTGAAACTGCCCACAGACCCTTCCAGCGATGAGCCTGTCTTCCACATT
TCCCACATTGATCGGGTCTACACCCTCCGAACAGACAACATTAATGAGAGGACCGCCTGGGTGCAGAAGATCAAGGCGGCGTCTGAGCAG
TACATCGACACCGAGAAGAAGAAGCGTGAGAAAGCTTACCAAGCCCGCTCCCAAAAGACTTCAGGCATTGGGCGCCTGATGGTGCATGTC
ATTGAAGCTACAGAATTAAAAGCCTGCAAACCAAATGGAAAGAGCAACCCATACTGTGAAATCAGCATGGGCTCCCAGAGCTACACCACC
AGGACCATCCAGGACACACTCAATCCCAAGTGGAATTTTAACTGCCAGTTCTTTATTAAGGATCTCTACCAAGACGTGCTGTGTCTCACC
CTGTTTGACAGAGACCAGTTTTCACCAGATGATTTCCTGGGTCGTACTGAAATTCCAGTGGCAAAAATTCGAACAGAACAGGAAAGCAAA
GGCCCTATGACCCGCCGACTGCTGCTGCATGAGGTCCCCACCGGGGAGGTCTGGGTCCGTTTTGACCTGCAGCTTTTTGAGCAAAAAACT
CTCCTGTAGGGGTTCTAAAGGACAGCACCAGCGGGACAGCCCACAAGGCTGGGGCTGGAGAATGAGAGACTGCGCTCTCTTGGGGCTGAG
GGAGCACCATGCAGCTTCACCCCTCACAAAGCCATGCACGCTGGGGGCTCTGTTTTCCTGCACACTAAATAGCTAGCAATCTATGCAAAC
ACCTTTCCCATAAAGAAACCAAACCCCATAGTACAGTGCCTTGTCCTAGTGTTCACATGTTCAGCTCTGTTTGTTTAGATGCCAAGGTTT
CCATTTTCAGGGCTATAAAAAGTATTACTTGGAAATGAGGCATCAGACCACCAGATGTTACCGCTCGGTTGAATGTGTCCACCGTGGAGT
GGTTTGGTGACGCTGTAACCATTCCACGCCAGTGACCTCTGCTGGGTCACAGCCACTCAGGAGGGGAAGGGTCAGGATGAGAGGCTGCAG
CCTCGACACTTGGCGCGGCCTGATACTGAAATAGCGTCTACTCGTGCACTGAATAAAAACAGAAACTTGATCATTTTATTCCTGATTAGA
TTTTATCACTCTCTGCTAAGACAATATAGTCTGGAGTATAAGTGGGAAAGCTTGATTTAAATACTGTGAACTCTAATAATGTGGAAAATA
TTTTTCAACTTTAATTTTCTGAAGTATAAATTATTTATGTAAATTCATTGTTTTTGCATATTTCTTAGGACATGCATCTTTAAGCTTTAT

>7310_7310_2_ASXL2-ITSN2_ASXL2_chr2_26022254_ENST00000435504_ITSN2_chr2_24538093_ENST00000361999_length(amino acids)=1841AA_BP=1
MLGCPPGLTSLFSHLSRHRGKSSAGQSRQGGRPEPGHGSLPVSSRPDMREKGRRKKGRTWAEAAKTVLEKYPNTPMSHKEILQVIQREGL
KEIRSGTSPLACLNAMLHTNSRGEEGIFYKVPGRMGVYTLKKDVPDGVKELSEGSEESSDGQSDSQSSENSSSSSDGGSNKEGKKSRWKR
KGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLAEIWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVL
PPIMKQPPMFSPLISARFGMGSMPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPIPYSSSTLPH
GSSYSLMMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAVPQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQ
TQLATIWTLADVDGDGQLKAEEFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLPVTFEDKRKA
NYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRR
LEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQN
KLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKELRETYNTQQLALEQLYK
IKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETA
SVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSATSTSSE
PLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSPGSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWF
GEVHGGRGWFPKSYVKIIPGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTGSIGDRS
GIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLG
PSSERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTLDTMQPI
ERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELS
HMQAYIRFCSCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKLALERAE
ELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRKLLHSGKLYKTKSNKELHGFLFNDFLLLTYMVKQFAVSSGSEK
LFSSKSNAQFKMYKTPIFLNEVLVKLPTDPSSDEPVFHISHIDRVYTLRTDNINERTAWVQKIKAASEQYIDTEKKKREKAYQARSQKTS
GIGRLMVHVIEATELKACKPNGKSNPYCEISMGSQSYTTRTIQDTLNPKWNFNCQFFIKDLYQDVLCLTLFDRDQFSPDDFLGRTEIPVA

--------------------------------------------------------------
>7310_7310_3_ASXL2-ITSN2_ASXL2_chr2_26022254_ENST00000435504_ITSN2_chr2_24538093_ENST00000406921_length(transcript)=4986nt_BP=697nt
ACAGTAGTGACGGCCGCGCGGGAGCGGTCACATGACCGTAGCGGCAGCCTGTACAGTAAGAACCCAATATGGCAGCGGCGGTAGCAGTGG
CAACGGCAGCAAGAGGACCGGCCGCCCCATAGACCCCCCCGCGCACCACCCCCGCCGCTTCCTCTGCTTGGGTGCCCCCCCGGTCTGACT
TCCCTTTTCTCCCACCTTTCCCGGCACCGCGGGAAAAGCAGCGCAGGGCAGAGCAGGCAGGGAGGGCGGCCGGAGCCCGGACACGGGAGC
CTCCCAGTCAGTTCAAGACCCGACATGAGGGAAAAGGGACGTAGGAAGAAGGGCAGGACCTGGGCGGAGGCCGCCAAGACGGTCTTAGAA
AAATACCCCAATACACCCATGAGTCATAAAGAAATTCTTCAAGTTATCCAGAGAGAAGGACTAAAAGAAATCAGAAGTGGGACTTCTCCT
CTTGCATGCCTGAATGCAATGCTTCACACAAACTCCAGAGGTGAAGAGGGCATCTTCTATAAGGTTCCAGGTAGAATGGGAGTATATACT
TTGAAGAAAGATGTGCCGGATGGGGTGAAAGAGCTGTCAGAAGGTTCAGAAGAAAGCAGTGATGGTCAGTCAGATTCCCAGAGTTCTGAG
AACAGCAGCAGCAGCAGTGATGGTGGCAGCAACAAGGAGGGAAAAAAGAGCAGGTGGAAAAGGAAAGGAGGGCCAAACATGTGGGCTATT
ACCTCTGAAGAACGTACTAAGCATGACAGGCAGTTTGATAACCTCAAACCTTCAGGAGGTTACATAACAGGTGATCAAGCACGTAATTTT
TTCCTACAATCAGGTCTGCCGGCCCCTGTTTTAGCTGAAATATGGGCTTTATCAGACCTAAACAAGGATGGGAAGATGGATCAGCAAGAG
TTCTCCATAGCTATGAAACTCATCAAACTGAAGCTTCAAGGCCAACAGTTGCCTGTGGTTCTCCCTCCTATTATGAAGCAACCCCCTATG
TTTTCTCCATTAATTTCTGCTCGTTTTGGAATGGGAAGCATGCCCAATCTGTCCATTCCTCAGCCATTGCCTCCAGCTGCACCTATAACA
TCATTGTCTTCTGCGACTTCAGGGACCAACCTTCCTCCCTTAATGATGCCCACTCCCCTAGTGCCTTCTGTTAGCACATCATCATTACCA
AATGGAACCGCCAGTCTCATTCAGCCTTTACCCATTCCTTATTCTTCTTCAACATTGCCTCATGGGTCATCTTATAGTCTGATGATGGGA
GGATTTGGAGGTGCTAGTATACAGAAAGCGCAGTCTCTGATTGATTTAGGATCTAGTAGCTCAACTTCCTCGACTGCTTCACTCTCAGGG
AACTCACCCAAGACTGGGACCTCAGAGTGGGCAGTTCCTCAGCCTACAAGATTAAAATATCGGCAAAAATTTAATACTCTTGACAAAAGT
ATGAGTGGATATCTCTCAGGTTTTCAAGCTAGAAATGCCCTTCTTCAGTCAAATCTTTCTCAAACTCAGCTGGCTACTATTTGGACTCTG
GCTGACGTTGATGGTGATGGACAGCTAAAAGCAGAAGAGTTTATTCTTGCAATGCACCTTACTGACATGGCCAAAGCTGGACAGCCATTA
CCACTGACTTTACCTCCTGAGCTTGTTCCTCCATCTTTCAGAGGAGGAAAGCAAATTGATTCCATTAATGGAACTCTGCCTTCATATCAG
AAAATGCAAGAAGAGGAGCCTCAGAAGAAATTACCAGTTACTTTTGAGGACAAACGGAAAGCCAACTATGAGCGAGGGAACATGGAGCTG
GAAAAGCGACGCCAAGCCTTGATGGAGCAGCAACAAAGGGAGGCAGAACGTAAAGCCCAGAAAGAAAAGGAAGAGTGGGAACGAAAACAG
AGAGAATTACAAGAACAAGAATGGAAGAAACAACTTGAATTAGAAAAACGCTTAGAGAAGCAACGGGAATTGGAGAGACAACGAGAGGAA
GAAAGGAGAAAAGACATAGAAAGACGAGAGGCAGCAAAACAGGAACTTGAACGACAACGTCGCTTAGAATGGGAGAGAATTCGGCGACAG
GAGCTTCTCAATCAAAAGAATAGAGAACAAGAAGAAATTGTCAGGTTAAACTCTAAAAAGAAGAATCTTCATCTTGAGTTGGAAGCACTG
AATGGCAAACATCAGCAGATCTCAGGCAGACTTCAGGATGTCCGACTCAAAAAGCAAACTCAAAAGACTGAGCTGGAAGTTCTGGATAAG
CAGTGTGACTTGGAAATTATGGAAATCAAGCAACTTCAACAGGAACTTCAGGAATATCAGAATAAGCTTATCTATCTGGTACCTGAGAAG
CAATTATTAAATGAAAGAATTAAAAACATGCAGTTCAGTAACACACCTGATTCAGGGGTCAGTTTACTTCATAAAAAATCATTAGAAAAG
GAAGAATTATGCCAAAGACTTAAAGAACAGTTAGATGCTCTTGAAAAAGAAACTGCATCTAAGCTGTCAGAAATGGATTCTTTTAACAAT
CAACTAAAGTGTGGGAATATGGATGACTCTGTTCTTCAGTGCCTTTTGTCTCTGCTAAGCTGTCTCAACAACCTCTTCCTCTTACTTAAG
GAACTGAGAGAAACCTACAACACACAGCAGTTAGCCCTTGAACAGCTTTATAAGATCAAACGTGACAAGTTGAAGGAAATTGAAAGGAAA
AGATTAGAACTAATGCAGAAAAAGAAACTAGAAGATGAGGCTGCAAGGAAAGCAAAGCAAGGAAAAGAAAACTTATGGAAAGAAAATCTT
AGAAAGGAGGAAGAAGAAAAACAAAAGCGACTCCAGGAAGAAAAAACACAAGAAAAAATTCAAGAAGAGGAACGGAAAGCTGAGGAGAAA
CAACGTAAGGATAAGGATACTTTGAAAGCTGAGGAGAAAAAACGTGAGACAGCTAGTGTTTTGGTGAATTATAGAGCATTATACCCCTTT
GAAGCAAGGAACCATGATGAGATGAGTTTTAATTCTGGAGATATAATTCAGGTTGATGAAAAAACCGTAGGAGAACCTGGTTGGCTTTAT
GGTAGTTTTCAAGGAAATTTTGGCTGGTTTCCATGCAATTATGTAGAAAAAATGCCATCAAGTGAAAATGAAAAAGCTGTATCTCCAAAG
AAGGCCTTACTTCCTCCTACAGTTTCTTTATCTGCTACCTCAACTTCCTCTGAACCACTTTCTTCAAATCAACCAGCATCAGTGACTGAT
TATCAAAATGTATCTTTTTCAAACCTAACTGTAAATACATCATGGCAGAAAAAATCAGCCTTCACTCGAACTGTGTCCCCTGGATCTGTA
TCACCTATTCATGGACAGGGACAAGTGGTAGAAAACTTAAAAGCACAGGCCCTTTGTTCCTGGACTGCAAAGAAAGATAACCACTTGAAC
TTCTCAAAACATGACATTATTACTGTCTTGGAGCAGCAAGAAAATTGGTGGTTTGGGGAGGTGCATGGAGGAAGAGGATGGTTTCCCAAA
TCTTATGTCAAGATCATTCCTGGGAGTGAAGTAAAACGGGAAGAACCAGAAGCTTTGTATGCAGCTGTAAATAAGAAACCTACCTCGGCA
GCCTATTCAGTTGGAGAAGAATATATTGCACTTTATCCATATTCAAGTGTGGAACCTGGAGATTTGACTTTCACAGAAGGTGAAGAAATA
TTGGTGACCCAGAAAGATGGAGAGTGGTGGACAGGAAGTATTGGAGATAGAAGTGGAATTTTTCCATCAAACTATGTCAAACCAAAGGAT
CAAGAGAGTTTTGGGAGTGCTAGCAAGTCTGGAGCATCAAATAAAAAACCTGAGATTGCTCAGGTAACTTCAGCATATGTTGCTTCTGGT
TCTGAACAACTTAGCCTTGCACCAGGACAGTTAATATTAATTCTAAAGAAAAATACAAGTGGGTGGTGGCAAGGAGAGTTACAGGCCAGA
GGAAAAAAGCGACAGAAAGGATGGTTTCCTGCCAGTCATGTTAAACTTTTGGGTCCAAGTAGTGAAAGAGCCACACCTGCCTTTCATCCT
GTATGTCAGGTGATTGCTATGTATGACTATGCAGCAAATAATGAAGATGAGCTCAGTTTCTCCAAGGGACAACTCATTAATGTTATGAAC
AAAGATGATCCTGATTGGTGGCAAGGAGAGATCAACGGGGTGACTGGTCTCTTTCCTTCAAACTACGTTAAGATGACGACAGACTCAGAT
CCAAGTCAACAGTGGTGTGCTGATCTGCAAACCCTGGACACAATGCAGCCAATTGAGAGGAAAAGACAGGGCTATATTCATGAGCTGATT
CAGACCGAAGAGCGGTACATGGCTGACCTTCAGCTCGTCGTCGAGGTGAGGAGGCTGCTGCTGGCTAGCTCTCGGGGTATCTGCTGTCTC
TCATGAGAGATGGTGGGCATCAGACTCAGGGCTGCCTCCACGCAGAGTCAAAGCAAGGCATCACTTTTGATGTGTGAATTCACAAATAGT
GACGGAAGCTCTCACATCCTCCAAATGCTGTCTCTGCCTGCCGGATAATGCTTGAGATTGAAAGTCTCTAATGAGCTCTTTCCCCCAGAT
GAGGTCACTCAGAGTGAAGCGGGAGAACAAGAGGGCATTCGCATGGCTTCGTTGGATGTGGCAGGAGCCCCATCAAGGAAGGACGGGGAT
AGAGTGGATGGGAAGGGCCTATGGCAGACCGTAGCTTCCTTGGATATTTGCCTAATATCTGTTTTAACATCTGACATTTTCATAAACTGG
TATCTCTGGAGGAACTGTGAAACAGTGAAAGTGTTCACCTCATGGTTGTATCAGTTTGGAAAACCCAATGGGAGCATATTGTAAAATAGT
TCCCAAATATCATATAGCTACTGTTTGTTTATACCAGTGACCTCTACGCTGATGACAGCTATCCTTATTCGAGTAGCACTTTAAAATGAT

>7310_7310_3_ASXL2-ITSN2_ASXL2_chr2_26022254_ENST00000435504_ITSN2_chr2_24538093_ENST00000406921_length(amino acids)=1420AA_BP=1
MLGCPPGLTSLFSHLSRHRGKSSAGQSRQGGRPEPGHGSLPVSSRPDMREKGRRKKGRTWAEAAKTVLEKYPNTPMSHKEILQVIQREGL
KEIRSGTSPLACLNAMLHTNSRGEEGIFYKVPGRMGVYTLKKDVPDGVKELSEGSEESSDGQSDSQSSENSSSSSDGGSNKEGKKSRWKR
KGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLAEIWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVL
PPIMKQPPMFSPLISARFGMGSMPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPIPYSSSTLPH
GSSYSLMMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAVPQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQ
TQLATIWTLADVDGDGQLKAEEFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLPVTFEDKRKA
NYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRR
LEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQN
KLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSC
LNNLFLLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQ
EEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSS
ENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSPGSVSPIHGQGQVVENLKAQALCSW
TAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGD
LTFTEGEEILVTQKDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSG
WWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSN

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Fusion Gene PPI Analysis for ASXL2-ITSN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ASXL2-ITSN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ASXL2-ITSN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource