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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ASXL2-PPWD1 (FusionGDB2 ID:7315)

Fusion Gene Summary for ASXL2-PPWD1

check button Fusion gene summary
Fusion gene informationFusion gene name: ASXL2-PPWD1
Fusion gene ID: 7315
HgeneTgene
Gene symbol

ASXL2

PPWD1

Gene ID

55252

23398

Gene nameASXL transcriptional regulator 2peptidylprolyl isomerase domain and WD repeat containing 1
SynonymsASXH2|SHAPNS-
Cytomap

2p23.3

5q12.3

Type of geneprotein-codingprotein-coding
Descriptionputative Polycomb group protein ASXL2additional sex combs like 2, transcriptional regulatoradditional sex combs-like protein 2polycomb group protein ASXH2peptidylprolyl isomerase domain and WD repeat-containing protein 1epididymis secretory sperm binding proteinspliceosome-associated cyclophilin
Modification date2020031320200313
UniProtAcc

Q76L83

.
Ensembl transtripts involved in fusion geneENST00000336112, ENST00000435504, 
ENST00000272341, ENST00000497092, 
ENST00000404843, 		ENST00000538977, 
ENST00000261308, ENST00000535264, 
Fusion gene scores* DoF score18 X 11 X 10=19804 X 3 X 5=60
# samples 246
** MAII scorelog2(24/1980*10)=-3.04439411935845
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/60*10)=0
Context

PubMed: ASXL2 [Title/Abstract] AND PPWD1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointASXL2(26029098)-PPWD1(64872706), # samples:2
Anticipated loss of major functional domain due to fusion event.ASXL2-PPWD1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
ASXL2-PPWD1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
ASXL2-PPWD1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ASXL2-PPWD1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneASXL2

GO:0035360

positive regulation of peroxisome proliferator activated receptor signaling pathway

21047783

HgeneASXL2

GO:0045600

positive regulation of fat cell differentiation

21047783

HgeneASXL2

GO:0045944

positive regulation of transcription by RNA polymerase II

21047783

TgenePPWD1

GO:0000413

protein peptidyl-prolyl isomerization

20676357


check buttonFusion gene breakpoints across ASXL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PPWD1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ACCTCGA-OR-A5J2-01AASXL2chr2

26029098

-PPWD1chr5

64863340

+
ChimerDB4ACCTCGA-OR-A5J2-01AASXL2chr2

26029098

-PPWD1chr5

64872706

+


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Fusion Gene ORF analysis for ASXL2-PPWD1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000336112ENST00000538977ASXL2chr2

26029098

-PPWD1chr5

64863340

+
5CDS-intronENST00000435504ENST00000538977ASXL2chr2

26029098

-PPWD1chr5

64863340

+
5UTR-3CDSENST00000272341ENST00000261308ASXL2chr2

26029098

-PPWD1chr5

64863340

+
5UTR-3CDSENST00000272341ENST00000261308ASXL2chr2

26029098

-PPWD1chr5

64872706

+
5UTR-3CDSENST00000272341ENST00000535264ASXL2chr2

26029098

-PPWD1chr5

64863340

+
5UTR-3CDSENST00000272341ENST00000535264ASXL2chr2

26029098

-PPWD1chr5

64872706

+
5UTR-3CDSENST00000272341ENST00000538977ASXL2chr2

26029098

-PPWD1chr5

64872706

+
5UTR-3CDSENST00000497092ENST00000261308ASXL2chr2

26029098

-PPWD1chr5

64863340

+
5UTR-3CDSENST00000497092ENST00000261308ASXL2chr2

26029098

-PPWD1chr5

64872706

+
5UTR-3CDSENST00000497092ENST00000535264ASXL2chr2

26029098

-PPWD1chr5

64863340

+
5UTR-3CDSENST00000497092ENST00000535264ASXL2chr2

26029098

-PPWD1chr5

64872706

+
5UTR-3CDSENST00000497092ENST00000538977ASXL2chr2

26029098

-PPWD1chr5

64872706

+
5UTR-intronENST00000272341ENST00000538977ASXL2chr2

26029098

-PPWD1chr5

64863340

+
5UTR-intronENST00000497092ENST00000538977ASXL2chr2

26029098

-PPWD1chr5

64863340

+
Frame-shiftENST00000336112ENST00000261308ASXL2chr2

26029098

-PPWD1chr5

64863340

+
Frame-shiftENST00000336112ENST00000261308ASXL2chr2

26029098

-PPWD1chr5

64872706

+
Frame-shiftENST00000336112ENST00000535264ASXL2chr2

26029098

-PPWD1chr5

64863340

+
Frame-shiftENST00000336112ENST00000535264ASXL2chr2

26029098

-PPWD1chr5

64872706

+
Frame-shiftENST00000336112ENST00000538977ASXL2chr2

26029098

-PPWD1chr5

64872706

+
Frame-shiftENST00000435504ENST00000261308ASXL2chr2

26029098

-PPWD1chr5

64863340

+
Frame-shiftENST00000435504ENST00000535264ASXL2chr2

26029098

-PPWD1chr5

64863340

+
In-frameENST00000435504ENST00000261308ASXL2chr2

26029098

-PPWD1chr5

64872706

+
In-frameENST00000435504ENST00000535264ASXL2chr2

26029098

-PPWD1chr5

64872706

+
In-frameENST00000435504ENST00000538977ASXL2chr2

26029098

-PPWD1chr5

64872706

+
intron-3CDSENST00000404843ENST00000261308ASXL2chr2

26029098

-PPWD1chr5

64863340

+
intron-3CDSENST00000404843ENST00000261308ASXL2chr2

26029098

-PPWD1chr5

64872706

+
intron-3CDSENST00000404843ENST00000535264ASXL2chr2

26029098

-PPWD1chr5

64863340

+
intron-3CDSENST00000404843ENST00000535264ASXL2chr2

26029098

-PPWD1chr5

64872706

+
intron-3CDSENST00000404843ENST00000538977ASXL2chr2

26029098

-PPWD1chr5

64872706

+
intron-intronENST00000404843ENST00000538977ASXL2chr2

26029098

-PPWD1chr5

64863340

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000435504ASXL2chr226029098-ENST00000261308PPWD1chr564872706+16715461531517454
ENST00000435504ASXL2chr226029098-ENST00000535264PPWD1chr564872706+15445461531517454
ENST00000435504ASXL2chr226029098-ENST00000538977PPWD1chr564872706+16495461531517454

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000435504ENST00000261308ASXL2chr226029098-PPWD1chr564872706+0.0009835290.9990164
ENST00000435504ENST00000535264ASXL2chr226029098-PPWD1chr564872706+0.0013935080.9986065
ENST00000435504ENST00000538977ASXL2chr226029098-PPWD1chr564872706+0.0010729070.99892706

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Fusion Genomic Features for ASXL2-PPWD1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ASXL2chr226029097-PPWD1chr564863339+1.70E-060.99999833
ASXL2chr226029097-PPWD1chr564872705+5.85E-081
ASXL2chr226029097-PPWD1chr564863339+1.70E-060.99999833
ASXL2chr226029097-PPWD1chr564872705+5.85E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ASXL2-PPWD1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:26029098/chr5:64872706)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ASXL2

Q76L83

.
FUNCTION: Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3. {ECO:0000250, ECO:0000269|PubMed:21047783}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneASXL2chr2:26029098chr5:64872706ENST00000435504-41311_86841436.0DomainHTH HARE-type
TgenePPWD1chr2:26029098chr5:64872706ENST00000261308411490_645323647.0DomainPPIase cyclophilin-type
TgenePPWD1chr2:26029098chr5:64872706ENST00000261308411345_386323647.0RepeatNote=WD 6
TgenePPWD1chr2:26029098chr5:64872706ENST00000261308411401_453323647.0RepeatNote=WD 7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneASXL2chr2:26029098chr5:64872706ENST00000272341-3131173_11760919.0Compositional biasNote=Poly-Ser
HgeneASXL2chr2:26029098chr5:64872706ENST00000272341-313303_3070919.0Compositional biasNote=Poly-Leu
HgeneASXL2chr2:26029098chr5:64872706ENST00000272341-313654_6840919.0Compositional biasNote=Ala-rich
HgeneASXL2chr2:26029098chr5:64872706ENST00000272341-313687_7390919.0Compositional biasNote=Gly-rich
HgeneASXL2chr2:26029098chr5:64872706ENST00000272341-31395_2350919.0Compositional biasNote=Ser-rich
HgeneASXL2chr2:26029098chr5:64872706ENST00000404843-1101173_11760919.0Compositional biasNote=Poly-Ser
HgeneASXL2chr2:26029098chr5:64872706ENST00000404843-110303_3070919.0Compositional biasNote=Poly-Leu
HgeneASXL2chr2:26029098chr5:64872706ENST00000404843-110654_6840919.0Compositional biasNote=Ala-rich
HgeneASXL2chr2:26029098chr5:64872706ENST00000404843-110687_7390919.0Compositional biasNote=Gly-rich
HgeneASXL2chr2:26029098chr5:64872706ENST00000404843-11095_2350919.0Compositional biasNote=Ser-rich
HgeneASXL2chr2:26029098chr5:64872706ENST00000435504-4131173_1176841436.0Compositional biasNote=Poly-Ser
HgeneASXL2chr2:26029098chr5:64872706ENST00000435504-413303_307841436.0Compositional biasNote=Poly-Leu
HgeneASXL2chr2:26029098chr5:64872706ENST00000435504-413654_684841436.0Compositional biasNote=Ala-rich
HgeneASXL2chr2:26029098chr5:64872706ENST00000435504-413687_739841436.0Compositional biasNote=Gly-rich
HgeneASXL2chr2:26029098chr5:64872706ENST00000435504-41395_235841436.0Compositional biasNote=Ser-rich
HgeneASXL2chr2:26029098chr5:64872706ENST00000272341-31311_860919.0DomainHTH HARE-type
HgeneASXL2chr2:26029098chr5:64872706ENST00000272341-313274_3830919.0DomainDEUBAD
HgeneASXL2chr2:26029098chr5:64872706ENST00000404843-11011_860919.0DomainHTH HARE-type
HgeneASXL2chr2:26029098chr5:64872706ENST00000404843-110274_3830919.0DomainDEUBAD
HgeneASXL2chr2:26029098chr5:64872706ENST00000435504-413274_383841436.0DomainDEUBAD
HgeneASXL2chr2:26029098chr5:64872706ENST00000272341-313174_1780919.0MotifNuclear localization signal
HgeneASXL2chr2:26029098chr5:64872706ENST00000272341-313887_8910919.0MotifNote=LXXLL motif 2
HgeneASXL2chr2:26029098chr5:64872706ENST00000404843-110174_1780919.0MotifNuclear localization signal
HgeneASXL2chr2:26029098chr5:64872706ENST00000404843-110887_8910919.0MotifNote=LXXLL motif 2
HgeneASXL2chr2:26029098chr5:64872706ENST00000435504-413174_178841436.0MotifNuclear localization signal
HgeneASXL2chr2:26029098chr5:64872706ENST00000435504-413887_891841436.0MotifNote=LXXLL motif 2
HgeneASXL2chr2:26029098chr5:64872706ENST00000272341-3131397_14340919.0Zinc fingerNote=PHD-type%3B atypical
HgeneASXL2chr2:26029098chr5:64872706ENST00000404843-1101397_14340919.0Zinc fingerNote=PHD-type%3B atypical
HgeneASXL2chr2:26029098chr5:64872706ENST00000435504-4131397_1434841436.0Zinc fingerNote=PHD-type%3B atypical
TgenePPWD1chr2:26029098chr5:64872706ENST0000026130841112_17323647.0Compositional biasNote=Poly-Arg
TgenePPWD1chr2:26029098chr5:64872706ENST00000261308411124_162323647.0RepeatNote=WD 2
TgenePPWD1chr2:26029098chr5:64872706ENST00000261308411168_208323647.0RepeatNote=WD 3
TgenePPWD1chr2:26029098chr5:64872706ENST00000261308411213_252323647.0RepeatNote=WD 4
TgenePPWD1chr2:26029098chr5:64872706ENST00000261308411271_309323647.0RepeatNote=WD 5
TgenePPWD1chr2:26029098chr5:64872706ENST0000026130841180_118323647.0RepeatNote=WD 1


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Fusion Gene Sequence for ASXL2-PPWD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>7315_7315_1_ASXL2-PPWD1_ASXL2_chr2_26029098_ENST00000435504_PPWD1_chr5_64872706_ENST00000261308_length(transcript)=1671nt_BP=546nt
ACAGTAGTGACGGCCGCGCGGGAGCGGTCACATGACCGTAGCGGCAGCCTGTACAGTAAGAACCCAATATGGCAGCGGCGGTAGCAGTGG
CAACGGCAGCAAGAGGACCGGCCGCCCCATAGACCCCCCCGCGCACCACCCCCGCCGCTTCCTCTGCTTGGGTGCCCCCCCGGTCTGACT
TCCCTTTTCTCCCACCTTTCCCGGCACCGCGGGAAAAGCAGCGCAGGGCAGAGCAGGCAGGGAGGGCGGCCGGAGCCCGGACACGGGAGC
CTCCCAGTCAGTTCAAGACCCGACATGAGGGAAAAGGGACGTAGGAAGAAGGGCAGGACCTGGGCGGAGGCCGCCAAGACGGTCTTAGAA
AAATACCCCAATACACCCATGAGTCATAAAGAAATTCTTCAAGTTATCCAGAGAGAAGGACTAAAAGAAATCAGAAGTGGGACTTCTCCT
CTTGCATGCCTGAATGCAATGCTTCACACAAACTCCAGAGGTGAAGAGGGCATCTTCTATAAGGTTCCAGGTAGAATGGGAGTATATACT
TTGAAGATGTTTACTGAACTGCAACAGATGAGGCAACAGTTACCAGACATGGAATTTGGCCGACGAATGGCTGTAGAACGTGAGTTGGAG
AAGGTTGATGCTGTAAGATTAATTAATATAGTTTTTGATGAAACTGGACACTTCGTGCTGTATGGAACAATGCTGGGCATTAAAGTTATA
AATGTAGAGACAAACCGGTGTGTGCGGATTTTAGGCAAACAAGAAAATATTAGAGTGATGCAATTGGCTTTGTTCCAGGGGATAGCCAAA
AAGCATCGTGCTGCAACTACTATAGAAATGAAAGCTTCTGAAAATCCTGTTCTTCAGAATATTCAAGCTGACCCAACAATAGTCTGTACA
TCATTCAAAAAGAATAGATTTTATATGTTTACCAAACGAGAACCAGAAGATACGAAAAGTGCAGATTCTGATCGAGATGTTTTTAATGAG
AAACCTTCTAAAGAAGAAGTCATGGCAGCTACTCAAGCTGAAGGACCTAAACGAGTTTCGGACAGTGCCATTATCCACACCAGCATGGGA
GACATTCACACCAAACTTTTTCCTGTTGAGTGCCCTAAGACAGTGGAAAACTTCTGTGTTCACAGCAGAAATGGTTATTATAATGGGCAT
ACATTTCACCGTATAATTAAGGGCTTTATGATTCAGACTGGAGATCCAACAGGTACTGGTATGGGAGGAGAAAGCATATGGGGAGGAGAA
TTTGAAGATGAATTTCATTCAACATTACGACATGACAGGCCATACACACTCAGCATGGCTAACGCGGGATCAAATACTAATGGATCCCAG
TTTTTCATAACGGTAGTACCAACGCCTTGGCTTGATAATAAGCATACAGTATTTGGACGAGTGACTAAAGGAATGGAAGTTGTACAGAGG
ATCTCCAACGTCAAAGTCAATCCCAAAACAGATAAGCCCTATGAGGATGTCAGCATCATAAATATTACTGTCAAGTAAAATAAGATTTGT
TTTAATGTACTTGCAAATAAAAATACAATATTAAACAGATTATTTTACATTAGGAAGCTTAGGACTTGCTGAATATACAGATCATGTTTC

>7315_7315_1_ASXL2-PPWD1_ASXL2_chr2_26029098_ENST00000435504_PPWD1_chr5_64872706_ENST00000261308_length(amino acids)=454AA_BP=131
MLGCPPGLTSLFSHLSRHRGKSSAGQSRQGGRPEPGHGSLPVSSRPDMREKGRRKKGRTWAEAAKTVLEKYPNTPMSHKEILQVIQREGL
KEIRSGTSPLACLNAMLHTNSRGEEGIFYKVPGRMGVYTLKMFTELQQMRQQLPDMEFGRRMAVERELEKVDAVRLINIVFDETGHFVLY
GTMLGIKVINVETNRCVRILGKQENIRVMQLALFQGIAKKHRAATTIEMKASENPVLQNIQADPTIVCTSFKKNRFYMFTKREPEDTKSA
DSDRDVFNEKPSKEEVMAATQAEGPKRVSDSAIIHTSMGDIHTKLFPVECPKTVENFCVHSRNGYYNGHTFHRIIKGFMIQTGDPTGTGM
GGESIWGGEFEDEFHSTLRHDRPYTLSMANAGSNTNGSQFFITVVPTPWLDNKHTVFGRVTKGMEVVQRISNVKVNPKTDKPYEDVSIIN

--------------------------------------------------------------
>7315_7315_2_ASXL2-PPWD1_ASXL2_chr2_26029098_ENST00000435504_PPWD1_chr5_64872706_ENST00000535264_length(transcript)=1544nt_BP=546nt
ACAGTAGTGACGGCCGCGCGGGAGCGGTCACATGACCGTAGCGGCAGCCTGTACAGTAAGAACCCAATATGGCAGCGGCGGTAGCAGTGG
CAACGGCAGCAAGAGGACCGGCCGCCCCATAGACCCCCCCGCGCACCACCCCCGCCGCTTCCTCTGCTTGGGTGCCCCCCCGGTCTGACT
TCCCTTTTCTCCCACCTTTCCCGGCACCGCGGGAAAAGCAGCGCAGGGCAGAGCAGGCAGGGAGGGCGGCCGGAGCCCGGACACGGGAGC
CTCCCAGTCAGTTCAAGACCCGACATGAGGGAAAAGGGACGTAGGAAGAAGGGCAGGACCTGGGCGGAGGCCGCCAAGACGGTCTTAGAA
AAATACCCCAATACACCCATGAGTCATAAAGAAATTCTTCAAGTTATCCAGAGAGAAGGACTAAAAGAAATCAGAAGTGGGACTTCTCCT
CTTGCATGCCTGAATGCAATGCTTCACACAAACTCCAGAGGTGAAGAGGGCATCTTCTATAAGGTTCCAGGTAGAATGGGAGTATATACT
TTGAAGATGTTTACTGAACTGCAACAGATGAGGCAACAGTTACCAGACATGGAATTTGGCCGACGAATGGCTGTAGAACGTGAGTTGGAG
AAGGTTGATGCTGTAAGATTAATTAATATAGTTTTTGATGAAACTGGACACTTCGTGCTGTATGGAACAATGCTGGGCATTAAAGTTATA
AATGTAGAGACAAACCGGTGTGTGCGGATTTTAGGCAAACAAGAAAATATTAGAGTGATGCAATTGGCTTTGTTCCAGGGGATAGCCAAA
AAGCATCGTGCTGCAACTACTATAGAAATGAAAGCTTCTGAAAATCCTGTTCTTCAGAATATTCAAGCTGACCCAACAATAGTCTGTACA
TCATTCAAAAAGAATAGATTTTATATGTTTACCAAACGAGAACCAGAAGATACGAAAAGTGCAGATTCTGATCGAGATGTTTTTAATGAG
AAACCTTCTAAAGAAGAAGTCATGGCAGCTACTCAAGCTGAAGGACCTAAACGAGTTTCGGACAGTGCCATTATCCACACCAGCATGGGA
GACATTCACACCAAACTTTTTCCTGTTGAGTGCCCTAAGACAGTGGAAAACTTCTGTGTTCACAGCAGAAATGGTTATTATAATGGGCAT
ACATTTCACCGTATAATTAAGGGCTTTATGATTCAGACTGGAGATCCAACAGGTACTGGTATGGGAGGAGAAAGCATATGGGGAGGAGAA
TTTGAAGATGAATTTCATTCAACATTACGACATGACAGGCCATACACACTCAGCATGGCTAACGCGGGATCAAATACTAATGGATCCCAG
TTTTTCATAACGGTAGTACCAACGCCTTGGCTTGATAATAAGCATACAGTATTTGGACGAGTGACTAAAGGAATGGAAGTTGTACAGAGG
ATCTCCAACGTCAAAGTCAATCCCAAAACAGATAAGCCCTATGAGGATGTCAGCATCATAAATATTACTGTCAAGTAAAATAAGATTTGT

>7315_7315_2_ASXL2-PPWD1_ASXL2_chr2_26029098_ENST00000435504_PPWD1_chr5_64872706_ENST00000535264_length(amino acids)=454AA_BP=131
MLGCPPGLTSLFSHLSRHRGKSSAGQSRQGGRPEPGHGSLPVSSRPDMREKGRRKKGRTWAEAAKTVLEKYPNTPMSHKEILQVIQREGL
KEIRSGTSPLACLNAMLHTNSRGEEGIFYKVPGRMGVYTLKMFTELQQMRQQLPDMEFGRRMAVERELEKVDAVRLINIVFDETGHFVLY
GTMLGIKVINVETNRCVRILGKQENIRVMQLALFQGIAKKHRAATTIEMKASENPVLQNIQADPTIVCTSFKKNRFYMFTKREPEDTKSA
DSDRDVFNEKPSKEEVMAATQAEGPKRVSDSAIIHTSMGDIHTKLFPVECPKTVENFCVHSRNGYYNGHTFHRIIKGFMIQTGDPTGTGM
GGESIWGGEFEDEFHSTLRHDRPYTLSMANAGSNTNGSQFFITVVPTPWLDNKHTVFGRVTKGMEVVQRISNVKVNPKTDKPYEDVSIIN

--------------------------------------------------------------
>7315_7315_3_ASXL2-PPWD1_ASXL2_chr2_26029098_ENST00000435504_PPWD1_chr5_64872706_ENST00000538977_length(transcript)=1649nt_BP=546nt
ACAGTAGTGACGGCCGCGCGGGAGCGGTCACATGACCGTAGCGGCAGCCTGTACAGTAAGAACCCAATATGGCAGCGGCGGTAGCAGTGG
CAACGGCAGCAAGAGGACCGGCCGCCCCATAGACCCCCCCGCGCACCACCCCCGCCGCTTCCTCTGCTTGGGTGCCCCCCCGGTCTGACT
TCCCTTTTCTCCCACCTTTCCCGGCACCGCGGGAAAAGCAGCGCAGGGCAGAGCAGGCAGGGAGGGCGGCCGGAGCCCGGACACGGGAGC
CTCCCAGTCAGTTCAAGACCCGACATGAGGGAAAAGGGACGTAGGAAGAAGGGCAGGACCTGGGCGGAGGCCGCCAAGACGGTCTTAGAA
AAATACCCCAATACACCCATGAGTCATAAAGAAATTCTTCAAGTTATCCAGAGAGAAGGACTAAAAGAAATCAGAAGTGGGACTTCTCCT
CTTGCATGCCTGAATGCAATGCTTCACACAAACTCCAGAGGTGAAGAGGGCATCTTCTATAAGGTTCCAGGTAGAATGGGAGTATATACT
TTGAAGATGTTTACTGAACTGCAACAGATGAGGCAACAGTTACCAGACATGGAATTTGGCCGACGAATGGCTGTAGAACGTGAGTTGGAG
AAGGTTGATGCTGTAAGATTAATTAATATAGTTTTTGATGAAACTGGACACTTCGTGCTGTATGGAACAATGCTGGGCATTAAAGTTATA
AATGTAGAGACAAACCGGTGTGTGCGGATTTTAGGCAAACAAGAAAATATTAGAGTGATGCAATTGGCTTTGTTCCAGGGGATAGCCAAA
AAGCATCGTGCTGCAACTACTATAGAAATGAAAGCTTCTGAAAATCCTGTTCTTCAGAATATTCAAGCTGACCCAACAATAGTCTGTACA
TCATTCAAAAAGAATAGATTTTATATGTTTACCAAACGAGAACCAGAAGATACGAAAAGTGCAGATTCTGATCGAGATGTTTTTAATGAG
AAACCTTCTAAAGAAGAAGTCATGGCAGCTACTCAAGCTGAAGGACCTAAACGAGTTTCGGACAGTGCCATTATCCACACCAGCATGGGA
GACATTCACACCAAACTTTTTCCTGTTGAGTGCCCTAAGACAGTGGAAAACTTCTGTGTTCACAGCAGAAATGGTTATTATAATGGGCAT
ACATTTCACCGTATAATTAAGGGCTTTATGATTCAGACTGGAGATCCAACAGGTACTGGTATGGGAGGAGAAAGCATATGGGGAGGAGAA
TTTGAAGATGAATTTCATTCAACATTACGACATGACAGGCCATACACACTCAGCATGGCTAACGCGGGATCAAATACTAATGGATCCCAG
TTTTTCATAACGGTAGTACCAACGCCTTGGCTTGATAATAAGCATACAGTATTTGGACGAGTGACTAAAGGAATGGAAGTTGTACAGAGG
ATCTCCAACGTCAAAGTCAATCCCAAAACAGATAAGCCCTATGAGGATGTCAGCATCATAAATATTACTGTCAAGTAAAATAAGATTTGT
TTTAATGTACTTGCAAATAAAAATACAATATTAAACAGATTATTTTACATTAGGAAGCTTAGGACTTGCTGAATATACAGATCATGTTTC

>7315_7315_3_ASXL2-PPWD1_ASXL2_chr2_26029098_ENST00000435504_PPWD1_chr5_64872706_ENST00000538977_length(amino acids)=454AA_BP=131
MLGCPPGLTSLFSHLSRHRGKSSAGQSRQGGRPEPGHGSLPVSSRPDMREKGRRKKGRTWAEAAKTVLEKYPNTPMSHKEILQVIQREGL
KEIRSGTSPLACLNAMLHTNSRGEEGIFYKVPGRMGVYTLKMFTELQQMRQQLPDMEFGRRMAVERELEKVDAVRLINIVFDETGHFVLY
GTMLGIKVINVETNRCVRILGKQENIRVMQLALFQGIAKKHRAATTIEMKASENPVLQNIQADPTIVCTSFKKNRFYMFTKREPEDTKSA
DSDRDVFNEKPSKEEVMAATQAEGPKRVSDSAIIHTSMGDIHTKLFPVECPKTVENFCVHSRNGYYNGHTFHRIIKGFMIQTGDPTGTGM
GGESIWGGEFEDEFHSTLRHDRPYTLSMANAGSNTNGSQFFITVVPTPWLDNKHTVFGRVTKGMEVVQRISNVKVNPKTDKPYEDVSIIN

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ASXL2-PPWD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ASXL2-PPWD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ASXL2-PPWD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource