Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:RCOR1-AMN (FusionGDB2 ID:73321)

Fusion Gene Summary for RCOR1-AMN

Fusion gene summary

Fusion gene information	Fusion gene name: RCOR1-AMN
	Fusion gene ID: 73321
		Hgene	Tgene
	Gene symbol	RCOR1	AMN
	Gene ID	23186	81693
	Gene name	REST corepressor 1	amnion associated transmembrane protein
	Synonyms	COREST\|RCOR	PRO1028\|amnionless
	Cytomap	14q32.31-q32.32	14q32.32
	Type of gene	protein-coding	protein-coding
	Description	REST corepressor 1	protein amnionlessamnionless homologvisceral endoderm-specific type 1 transmembrane protein
	Modification date	20200313	20200313
	UniProtAcc	.	Q8IY45
	Ensembl transtripts involved in fusion gene	ENST00000262241, ENST00000570597,	ENST00000299155,
Fusion gene scores	* DoF score	10 X 9 X 10=900	3 X 5 X 3=45
	# samples	20	4
	** MAII score	log2(20/900*10)=-2.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/45*10)=-0.169925001442312 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: RCOR1 [Title/Abstract] AND AMN [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	RCOR1(103059662)-AMN(103390048), # samples:2
Anticipated loss of major functional domain due to fusion event.	RCOR1-AMN seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. RCOR1-AMN seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. RCOR1-AMN seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. RCOR1-AMN seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RCOR1	GO:0045892	negative regulation of transcription, DNA-templated	10449787
Hgene	RCOR1	GO:0070933	histone H4 deacetylation	17555596
Tgene	AMN	GO:0006898	receptor-mediated endocytosis	14576052
Tgene	AMN	GO:0015889	cobalamin transport	14576052
Tgene	AMN	GO:0043001	Golgi to plasma membrane protein transport	14576052

Fusion gene breakpoints across RCOR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across AMN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-VQ-A928-01A	RCOR1	chr14	103059662	+	AMN	chr14	103390048	+
ChimerDB4	STAD	TCGA-VQ-A928-01A	RCOR1	chr14	103059662	+	AMN	chr14	103390272	+
ChimerDB4	STAD	TCGA-VQ-A928	RCOR1	chr14	103059662	+	AMN	chr14	103390047	+

Top

Fusion Gene ORF analysis for RCOR1-AMN

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000262241	ENST00000299155	RCOR1	chr14	103059662	+	AMN	chr14	103390272	+
Frame-shift	ENST00000570597	ENST00000299155	RCOR1	chr14	103059662	+	AMN	chr14	103390272	+
In-frame	ENST00000262241	ENST00000299155	RCOR1	chr14	103059662	+	AMN	chr14	103390048	+
In-frame	ENST00000262241	ENST00000299155	RCOR1	chr14	103059662	+	AMN	chr14	103390047	+
In-frame	ENST00000570597	ENST00000299155	RCOR1	chr14	103059662	+	AMN	chr14	103390048	+
In-frame	ENST00000570597	ENST00000299155	RCOR1	chr14	103059662	+	AMN	chr14	103390047	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000262241

RCOR1

chr14

103059662

ENST00000299155

AMN

chr14

103390048

2418

587

1905

626

ENST00000570597

RCOR1

chr14

103059662

ENST00000299155

AMN

chr14

103390048

2183

352

1670

556

ENST00000262241

RCOR1

chr14

103059662

ENST00000299155

AMN

chr14

103390047

2418

587

1905

626

ENST00000570597

RCOR1

chr14

103059662

ENST00000299155

AMN

chr14

103390047

2183

352

1670

556

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000262241	ENST00000299155	RCOR1	chr14	103059662	+	AMN	chr14	103390048	+	0.06587295	0.934127
ENST00000570597	ENST00000299155	RCOR1	chr14	103059662	+	AMN	chr14	103390048	+	0.06324657	0.9367534
ENST00000262241	ENST00000299155	RCOR1	chr14	103059662	+	AMN	chr14	103390047	+	0.06587295	0.934127
ENST00000570597	ENST00000299155	RCOR1	chr14	103059662	+	AMN	chr14	103390047	+	0.06324657	0.9367534

Top

Fusion Genomic Features for RCOR1-AMN

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
RCOR1	chr14	103059662	+	AMN	chr14	103390271	+	0.58042574	0.4195742
RCOR1	chr14	103059662	+	AMN	chr14	103390047	+	2.08E-10	1
RCOR1	chr14	103059662	+	AMN	chr14	103390047	+	2.08E-10	1
RCOR1	chr14	103059662	+	AMN	chr14	103390271	+	0.58042574	0.4195742
RCOR1	chr14	103059662	+	AMN	chr14	103390047	+	2.08E-10	1
RCOR1	chr14	103059662	+	AMN	chr14	103390047	+	2.08E-10	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for RCOR1-AMN

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:103059662/chr14:103390048)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	AMN Q8IY45
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RCOR1

chr14:103059662

chr14:103390047

ENST00000570597

21_77

117

483.0

Compositional bias

Note=Ala-rich

Hgene

RCOR1

chr14:103059662

chr14:103390048

ENST00000570597

21_77

117

483.0

Compositional bias

Note=Ala-rich

Tgene

AMN

chr14:103059662

chr14:103390047

ENST00000299155

202_254

454.0

Domain

Note=VWFC

Tgene

AMN

chr14:103059662

chr14:103390048

ENST00000299155

202_254

454.0

Domain

Note=VWFC

Tgene

AMN

chr14:103059662

chr14:103390047

ENST00000299155

20_357

454.0

Topological domain

Extracellular

Tgene

AMN

chr14:103059662

chr14:103390047

ENST00000299155

379_453

454.0

Topological domain

Cytoplasmic

Tgene

AMN

chr14:103059662

chr14:103390048

ENST00000299155

20_357

454.0

Topological domain

Extracellular

Tgene

AMN

chr14:103059662

chr14:103390048

ENST00000299155

379_453

454.0

Topological domain

Cytoplasmic

Tgene

AMN

chr14:103059662

chr14:103390047

ENST00000299155

358_378

454.0

Transmembrane

Helical

Tgene

AMN

chr14:103059662

chr14:103390048

ENST00000299155

358_378

454.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RCOR1

chr14:103059662

chr14:103390047

ENST00000570597

244_273

117

483.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

RCOR1

chr14:103059662

chr14:103390047

ENST00000570597

334_369

117

483.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

RCOR1

chr14:103059662

chr14:103390048

ENST00000570597

244_273

117

483.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

RCOR1

chr14:103059662

chr14:103390048

ENST00000570597

334_369

117

483.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

RCOR1

chr14:103059662

chr14:103390047

ENST00000570597

103_189

117

483.0

Domain

ELM2

Hgene

RCOR1

chr14:103059662

chr14:103390047

ENST00000570597

190_241

117

483.0

Domain

SANT 1

Hgene

RCOR1

chr14:103059662

chr14:103390047

ENST00000570597

381_432

117

483.0

Domain

SANT 2

Hgene

RCOR1

chr14:103059662

chr14:103390048

ENST00000570597

103_189

117

483.0

Domain

ELM2

Hgene

RCOR1

chr14:103059662

chr14:103390048

ENST00000570597

190_241

117

483.0

Domain

SANT 1

Hgene

RCOR1

chr14:103059662

chr14:103390048

ENST00000570597

381_432

117

483.0

Domain

SANT 2

Top

Fusion Gene Sequence for RCOR1-AMN

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>73321_73321_1_RCOR1-AMN_RCOR1_chr14_103059662_ENST00000262241_AMN_chr14_103390047_ENST00000299155_length(transcript)=2418nt_BP=587nt
GTGAGGGCGGCGATGAGAGCGAAAGTTGCGCTCGGCTCGTCGCTGGGGGCTTGAAGCGGCTCCGCGCTCTGCCCGTTTGGGCCTCCCCCG
ACTCGGACTCGCGCCCGTGGGCTCCCGCCGCGCCCGCCCGGCCCCGCGCCGGCCCCGCGCCCCCTCCCCCGTCTCGGCGCCCCCTCCTCA
GGAGCCGCGGGTCCCCGCCACTTTCGCACGGCCCCGGCCCCCGCCGATGCCGGCCATGGTGGAGAAGGGCCCCGAGGTCTCAGGGAAGCG
GAGAGGGAGGAACAACGCGGCCGCCTCCGCCTCCGCCGCCGCCGCCTCCGCCGCCGCCTCGGCCGCCTGCGCCTCGCCAGCCGCCACTGC
CGCCTCGGGCGCCGCCGCCTCCTCAGCCTCGGCCGCCGCCGCCTCAGCCGCCGCCGCCCCCAATAATGGCCAGAATAAAAGTTTGGCGGC
GGCGGCGCCCAATGGCAACAGCAGCAGCAACTCCTGGGAGGAAGGCAGCTCGGGCTCGTCCAGCGACGAGGAGCACGGTGGCGGTGGCAT
GAGGGTCGGACCCCAGTACCAGGCGGTGGTGCCCGACTTCGACCCCGCACTGACCCAGGCGGTCTCCAAACTCTGGGTCCCCAACACGGA
CTTCGACGTCGCAGCCAACTGGAGCCAGAACCGGACCCCGTGCGCCGGCGGCGCCGTTGAGTTCCCGGCGGACAAGATGGTGTCAGTCCT
GGTGCAAGAAGGTCACGCCGTCTCAGACATGCTCCTGCCGCTGGATGGGGAACTCGTCCTGGCTTCAGGAGCCGGATTCGGCGTCTCAGA
CGTGGGCTCGCACCTGGACTGTGGCGCGGGCGAACCTGCCGTCTTCCGCGACTCTGACCGCTTCTCCTGGCATGACCCGCACCTGTGGCG
CTCTGGGGACGAGGCACCTGGCCTCTTCTTCGTGGACGCCGAGCGCGTGCCCTGCCGCCACGACGACGTCTTCTTTCCGCCTAGTGCCTC
CTTCCGCGTGGGGCTCGGCCCTGGCGCTAGCCCCGTGCGTGTCCGCAGCATCTCGGCTCTGGGCCGGACGTTCACGCGCGACGAGGACCT
GGCTGTTTTCCTGGCGTCCCGCGCGGGCCGCCTACGCTTCCACGGGCCGGGCGCGCTGAGCGTGGGCCCCGAGGACTGCGCGGACCCGTC
GGGCTGCGTCTGCGGCAACGCGGAGGCGCAGCCGTGGATCTGCGCGGCCCTGCTCCAGCCCCTGGGCGGCCGCTGCCCCCAGGCCGCCTG
CCACAGCGCCCTCCGGCCCCAGGGGCAGTGCTGTGACCTCTGTGGAGCCGTTGTGTTGCTGACCCACGGCCCCGCATTTGACCTGGAGCG
GTACCGGGCGCGGATACTGGACACCTTCCTGGGTCTGCCTCAGTACCACGGGCTGCAGGTGGCCGTGTCCAAGGTGCCACGCTCGTCCCG
GCTCCGTGAGGCCGATACGGAGATCCAGGTGGTGCTGGTGGAGAATGGGCCCGAGACAGGCGGAGCGGGGCGGCTGGCCCGGGCCCTCCT
GGCGGACGTCGCCGAGAACGGCGAGGCCCTCGGCGTCCTGGAGGCGACCATGCGGGAGTCGGGCGCACACGTCTGGGGCAGCTCCGCGGC
TGGGCTGGCGGGCGGCGTGGCGGCTGCCGTGCTGCTGGCGCTGCTGGTCCTGCTGGTGGCGCCGCCGCTGCTGCGCCGCGCGGGGAGGCT
CAGGTGGAGGAGGCACGAGGCGGCGGCCCCGGCTGGAGCGCCCCTCGGCTTCCGCAACCCGGTGTTCGACGTGACGGCCTCCGAGGAGCT
GCCCCTGCCGCGGCGGCTCAGCCTGGTTCCGAAGGCGGCCGCAGACAGCACCAGCCACAGTTACTTCGTCAACCCTCTGTTCGCCGGGGC
CGAGGCCGAGGCCTGAGCGGCCGCCTGACCGTCGACCTTGGGGCTCTCCACCCGCTCTGGCCCCAGTCGAACTGGGGGCTAGCCACCTCC
TCGTCCAGCCCCCAAACCTCCCCTTCCTTTCCCCCTCCTCCGGGGGCCAAGGACAGGGTGGCCTTACTCAGTAAAGGTGTTTCCTGCACC
TGCTGTCAGCCTGGCTATGCCGCCACCGGCCCCGCCCATGAGGACTAGGAGCCCAGCCTTGCGCCGCATTCGCACTGGGGGACATGGGAG
GGGTCTAGCTGGCCACTGCTGGAGGCAGCGCTGGTCGTCACCTGGGCGGCCAGAGGCTGGGATCTGCGAAGTTGAACCCAGAACTAGGAG
TGGGGCTTCCCCCGCCTTCCGGTGAGGGGAGGGTGAGGAGCTGGAGGGAGGGGCGGGAGAGAGGCAAGGGGTGGACGGAGCCAAAGGCCG

>73321_73321_1_RCOR1-AMN_RCOR1_chr14_103059662_ENST00000262241_AMN_chr14_103390047_ENST00000299155_length(amino acids)=626AA_BP=19
MRSARRWGLEAAPRSARLGLPRLGLAPVGSRRARPAPRRPRAPSPVSAPPPQEPRVPATFARPRPPPMPAMVEKGPEVSGKRRGRNNAAA
SASAAAASAAASAACASPAATAASGAAASSASAAAASAAAAPNNGQNKSLAAAAPNGNSSSNSWEEGSSGSSSDEEHGGGGMRVGPQYQA
VVPDFDPALTQAVSKLWVPNTDFDVAANWSQNRTPCAGGAVEFPADKMVSVLVQEGHAVSDMLLPLDGELVLASGAGFGVSDVGSHLDCG
AGEPAVFRDSDRFSWHDPHLWRSGDEAPGLFFVDAERVPCRHDDVFFPPSASFRVGLGPGASPVRVRSISALGRTFTRDEDLAVFLASRA
GRLRFHGPGALSVGPEDCADPSGCVCGNAEAQPWICAALLQPLGGRCPQAACHSALRPQGQCCDLCGAVVLLTHGPAFDLERYRARILDT
FLGLPQYHGLQVAVSKVPRSSRLREADTEIQVVLVENGPETGGAGRLARALLADVAENGEALGVLEATMRESGAHVWGSSAAGLAGGVAA

--------------------------------------------------------------
>73321_73321_2_RCOR1-AMN_RCOR1_chr14_103059662_ENST00000262241_AMN_chr14_103390048_ENST00000299155_length(transcript)=2418nt_BP=587nt
GTGAGGGCGGCGATGAGAGCGAAAGTTGCGCTCGGCTCGTCGCTGGGGGCTTGAAGCGGCTCCGCGCTCTGCCCGTTTGGGCCTCCCCCG
ACTCGGACTCGCGCCCGTGGGCTCCCGCCGCGCCCGCCCGGCCCCGCGCCGGCCCCGCGCCCCCTCCCCCGTCTCGGCGCCCCCTCCTCA
GGAGCCGCGGGTCCCCGCCACTTTCGCACGGCCCCGGCCCCCGCCGATGCCGGCCATGGTGGAGAAGGGCCCCGAGGTCTCAGGGAAGCG
GAGAGGGAGGAACAACGCGGCCGCCTCCGCCTCCGCCGCCGCCGCCTCCGCCGCCGCCTCGGCCGCCTGCGCCTCGCCAGCCGCCACTGC
CGCCTCGGGCGCCGCCGCCTCCTCAGCCTCGGCCGCCGCCGCCTCAGCCGCCGCCGCCCCCAATAATGGCCAGAATAAAAGTTTGGCGGC
GGCGGCGCCCAATGGCAACAGCAGCAGCAACTCCTGGGAGGAAGGCAGCTCGGGCTCGTCCAGCGACGAGGAGCACGGTGGCGGTGGCAT
GAGGGTCGGACCCCAGTACCAGGCGGTGGTGCCCGACTTCGACCCCGCACTGACCCAGGCGGTCTCCAAACTCTGGGTCCCCAACACGGA
CTTCGACGTCGCAGCCAACTGGAGCCAGAACCGGACCCCGTGCGCCGGCGGCGCCGTTGAGTTCCCGGCGGACAAGATGGTGTCAGTCCT
GGTGCAAGAAGGTCACGCCGTCTCAGACATGCTCCTGCCGCTGGATGGGGAACTCGTCCTGGCTTCAGGAGCCGGATTCGGCGTCTCAGA
CGTGGGCTCGCACCTGGACTGTGGCGCGGGCGAACCTGCCGTCTTCCGCGACTCTGACCGCTTCTCCTGGCATGACCCGCACCTGTGGCG
CTCTGGGGACGAGGCACCTGGCCTCTTCTTCGTGGACGCCGAGCGCGTGCCCTGCCGCCACGACGACGTCTTCTTTCCGCCTAGTGCCTC
CTTCCGCGTGGGGCTCGGCCCTGGCGCTAGCCCCGTGCGTGTCCGCAGCATCTCGGCTCTGGGCCGGACGTTCACGCGCGACGAGGACCT
GGCTGTTTTCCTGGCGTCCCGCGCGGGCCGCCTACGCTTCCACGGGCCGGGCGCGCTGAGCGTGGGCCCCGAGGACTGCGCGGACCCGTC
GGGCTGCGTCTGCGGCAACGCGGAGGCGCAGCCGTGGATCTGCGCGGCCCTGCTCCAGCCCCTGGGCGGCCGCTGCCCCCAGGCCGCCTG
CCACAGCGCCCTCCGGCCCCAGGGGCAGTGCTGTGACCTCTGTGGAGCCGTTGTGTTGCTGACCCACGGCCCCGCATTTGACCTGGAGCG
GTACCGGGCGCGGATACTGGACACCTTCCTGGGTCTGCCTCAGTACCACGGGCTGCAGGTGGCCGTGTCCAAGGTGCCACGCTCGTCCCG
GCTCCGTGAGGCCGATACGGAGATCCAGGTGGTGCTGGTGGAGAATGGGCCCGAGACAGGCGGAGCGGGGCGGCTGGCCCGGGCCCTCCT
GGCGGACGTCGCCGAGAACGGCGAGGCCCTCGGCGTCCTGGAGGCGACCATGCGGGAGTCGGGCGCACACGTCTGGGGCAGCTCCGCGGC
TGGGCTGGCGGGCGGCGTGGCGGCTGCCGTGCTGCTGGCGCTGCTGGTCCTGCTGGTGGCGCCGCCGCTGCTGCGCCGCGCGGGGAGGCT
CAGGTGGAGGAGGCACGAGGCGGCGGCCCCGGCTGGAGCGCCCCTCGGCTTCCGCAACCCGGTGTTCGACGTGACGGCCTCCGAGGAGCT
GCCCCTGCCGCGGCGGCTCAGCCTGGTTCCGAAGGCGGCCGCAGACAGCACCAGCCACAGTTACTTCGTCAACCCTCTGTTCGCCGGGGC
CGAGGCCGAGGCCTGAGCGGCCGCCTGACCGTCGACCTTGGGGCTCTCCACCCGCTCTGGCCCCAGTCGAACTGGGGGCTAGCCACCTCC
TCGTCCAGCCCCCAAACCTCCCCTTCCTTTCCCCCTCCTCCGGGGGCCAAGGACAGGGTGGCCTTACTCAGTAAAGGTGTTTCCTGCACC
TGCTGTCAGCCTGGCTATGCCGCCACCGGCCCCGCCCATGAGGACTAGGAGCCCAGCCTTGCGCCGCATTCGCACTGGGGGACATGGGAG
GGGTCTAGCTGGCCACTGCTGGAGGCAGCGCTGGTCGTCACCTGGGCGGCCAGAGGCTGGGATCTGCGAAGTTGAACCCAGAACTAGGAG
TGGGGCTTCCCCCGCCTTCCGGTGAGGGGAGGGTGAGGAGCTGGAGGGAGGGGCGGGAGAGAGGCAAGGGGTGGACGGAGCCAAAGGCCG

>73321_73321_2_RCOR1-AMN_RCOR1_chr14_103059662_ENST00000262241_AMN_chr14_103390048_ENST00000299155_length(amino acids)=626AA_BP=19
MRSARRWGLEAAPRSARLGLPRLGLAPVGSRRARPAPRRPRAPSPVSAPPPQEPRVPATFARPRPPPMPAMVEKGPEVSGKRRGRNNAAA
SASAAAASAAASAACASPAATAASGAAASSASAAAASAAAAPNNGQNKSLAAAAPNGNSSSNSWEEGSSGSSSDEEHGGGGMRVGPQYQA
VVPDFDPALTQAVSKLWVPNTDFDVAANWSQNRTPCAGGAVEFPADKMVSVLVQEGHAVSDMLLPLDGELVLASGAGFGVSDVGSHLDCG
AGEPAVFRDSDRFSWHDPHLWRSGDEAPGLFFVDAERVPCRHDDVFFPPSASFRVGLGPGASPVRVRSISALGRTFTRDEDLAVFLASRA
GRLRFHGPGALSVGPEDCADPSGCVCGNAEAQPWICAALLQPLGGRCPQAACHSALRPQGQCCDLCGAVVLLTHGPAFDLERYRARILDT
FLGLPQYHGLQVAVSKVPRSSRLREADTEIQVVLVENGPETGGAGRLARALLADVAENGEALGVLEATMRESGAHVWGSSAAGLAGGVAA

--------------------------------------------------------------
>73321_73321_3_RCOR1-AMN_RCOR1_chr14_103059662_ENST00000570597_AMN_chr14_103390047_ENST00000299155_length(transcript)=2183nt_BP=352nt
ATGGTGGAGAAGGGCCCCGAGGTCTCAGGGAAGCGGAGAGGGAGGAACAACGCGGCCGCCTCCGCCTCCGCCGCCGCCGCCTCCGCCGCC
GCCTCGGCCGCCTGCGCCTCGCCAGCCGCCACTGCCGCCTCGGGCGCCGCCGCCTCCTCAGCCTCGGCCGCCGCCGCCTCAGCCGCCGCC
GCCCCCAATAATGGCCAGAATAAAAGTTTGGCGGCGGCGGCGCCCAATGGCAACAGCAGCAGCAACTCCTGGGAGGAAGGCAGCTCGGGC
TCGTCCAGCGACGAGGAGCACGGTGGCGGTGGCATGAGGGTCGGACCCCAGTACCAGGCGGTGGTGCCCGACTTCGACCCCGCACTGACC
CAGGCGGTCTCCAAACTCTGGGTCCCCAACACGGACTTCGACGTCGCAGCCAACTGGAGCCAGAACCGGACCCCGTGCGCCGGCGGCGCC
GTTGAGTTCCCGGCGGACAAGATGGTGTCAGTCCTGGTGCAAGAAGGTCACGCCGTCTCAGACATGCTCCTGCCGCTGGATGGGGAACTC
GTCCTGGCTTCAGGAGCCGGATTCGGCGTCTCAGACGTGGGCTCGCACCTGGACTGTGGCGCGGGCGAACCTGCCGTCTTCCGCGACTCT
GACCGCTTCTCCTGGCATGACCCGCACCTGTGGCGCTCTGGGGACGAGGCACCTGGCCTCTTCTTCGTGGACGCCGAGCGCGTGCCCTGC
CGCCACGACGACGTCTTCTTTCCGCCTAGTGCCTCCTTCCGCGTGGGGCTCGGCCCTGGCGCTAGCCCCGTGCGTGTCCGCAGCATCTCG
GCTCTGGGCCGGACGTTCACGCGCGACGAGGACCTGGCTGTTTTCCTGGCGTCCCGCGCGGGCCGCCTACGCTTCCACGGGCCGGGCGCG
CTGAGCGTGGGCCCCGAGGACTGCGCGGACCCGTCGGGCTGCGTCTGCGGCAACGCGGAGGCGCAGCCGTGGATCTGCGCGGCCCTGCTC
CAGCCCCTGGGCGGCCGCTGCCCCCAGGCCGCCTGCCACAGCGCCCTCCGGCCCCAGGGGCAGTGCTGTGACCTCTGTGGAGCCGTTGTG
TTGCTGACCCACGGCCCCGCATTTGACCTGGAGCGGTACCGGGCGCGGATACTGGACACCTTCCTGGGTCTGCCTCAGTACCACGGGCTG
CAGGTGGCCGTGTCCAAGGTGCCACGCTCGTCCCGGCTCCGTGAGGCCGATACGGAGATCCAGGTGGTGCTGGTGGAGAATGGGCCCGAG
ACAGGCGGAGCGGGGCGGCTGGCCCGGGCCCTCCTGGCGGACGTCGCCGAGAACGGCGAGGCCCTCGGCGTCCTGGAGGCGACCATGCGG
GAGTCGGGCGCACACGTCTGGGGCAGCTCCGCGGCTGGGCTGGCGGGCGGCGTGGCGGCTGCCGTGCTGCTGGCGCTGCTGGTCCTGCTG
GTGGCGCCGCCGCTGCTGCGCCGCGCGGGGAGGCTCAGGTGGAGGAGGCACGAGGCGGCGGCCCCGGCTGGAGCGCCCCTCGGCTTCCGC
AACCCGGTGTTCGACGTGACGGCCTCCGAGGAGCTGCCCCTGCCGCGGCGGCTCAGCCTGGTTCCGAAGGCGGCCGCAGACAGCACCAGC
CACAGTTACTTCGTCAACCCTCTGTTCGCCGGGGCCGAGGCCGAGGCCTGAGCGGCCGCCTGACCGTCGACCTTGGGGCTCTCCACCCGC
TCTGGCCCCAGTCGAACTGGGGGCTAGCCACCTCCTCGTCCAGCCCCCAAACCTCCCCTTCCTTTCCCCCTCCTCCGGGGGCCAAGGACA
GGGTGGCCTTACTCAGTAAAGGTGTTTCCTGCACCTGCTGTCAGCCTGGCTATGCCGCCACCGGCCCCGCCCATGAGGACTAGGAGCCCA
GCCTTGCGCCGCATTCGCACTGGGGGACATGGGAGGGGTCTAGCTGGCCACTGCTGGAGGCAGCGCTGGTCGTCACCTGGGCGGCCAGAG
GCTGGGATCTGCGAAGTTGAACCCAGAACTAGGAGTGGGGCTTCCCCCGCCTTCCGGTGAGGGGAGGGTGAGGAGCTGGAGGGAGGGGCG
GGAGAGAGGCAAGGGGTGGACGGAGCCAAAGGCCGTGCCTGGTGGGGCGGACGGAAAAGGGGTGGGCATCCCTCCTGGTACCAAGCTGCT

>73321_73321_3_RCOR1-AMN_RCOR1_chr14_103059662_ENST00000570597_AMN_chr14_103390047_ENST00000299155_length(amino acids)=556AA_BP=17
MVEKGPEVSGKRRGRNNAAASASAAAASAAASAACASPAATAASGAAASSASAAAASAAAAPNNGQNKSLAAAAPNGNSSSNSWEEGSSG
SSSDEEHGGGGMRVGPQYQAVVPDFDPALTQAVSKLWVPNTDFDVAANWSQNRTPCAGGAVEFPADKMVSVLVQEGHAVSDMLLPLDGEL
VLASGAGFGVSDVGSHLDCGAGEPAVFRDSDRFSWHDPHLWRSGDEAPGLFFVDAERVPCRHDDVFFPPSASFRVGLGPGASPVRVRSIS
ALGRTFTRDEDLAVFLASRAGRLRFHGPGALSVGPEDCADPSGCVCGNAEAQPWICAALLQPLGGRCPQAACHSALRPQGQCCDLCGAVV
LLTHGPAFDLERYRARILDTFLGLPQYHGLQVAVSKVPRSSRLREADTEIQVVLVENGPETGGAGRLARALLADVAENGEALGVLEATMR
ESGAHVWGSSAAGLAGGVAAAVLLALLVLLVAPPLLRRAGRLRWRRHEAAAPAGAPLGFRNPVFDVTASEELPLPRRLSLVPKAAADSTS

--------------------------------------------------------------
>73321_73321_4_RCOR1-AMN_RCOR1_chr14_103059662_ENST00000570597_AMN_chr14_103390048_ENST00000299155_length(transcript)=2183nt_BP=352nt
ATGGTGGAGAAGGGCCCCGAGGTCTCAGGGAAGCGGAGAGGGAGGAACAACGCGGCCGCCTCCGCCTCCGCCGCCGCCGCCTCCGCCGCC
GCCTCGGCCGCCTGCGCCTCGCCAGCCGCCACTGCCGCCTCGGGCGCCGCCGCCTCCTCAGCCTCGGCCGCCGCCGCCTCAGCCGCCGCC
GCCCCCAATAATGGCCAGAATAAAAGTTTGGCGGCGGCGGCGCCCAATGGCAACAGCAGCAGCAACTCCTGGGAGGAAGGCAGCTCGGGC
TCGTCCAGCGACGAGGAGCACGGTGGCGGTGGCATGAGGGTCGGACCCCAGTACCAGGCGGTGGTGCCCGACTTCGACCCCGCACTGACC
CAGGCGGTCTCCAAACTCTGGGTCCCCAACACGGACTTCGACGTCGCAGCCAACTGGAGCCAGAACCGGACCCCGTGCGCCGGCGGCGCC
GTTGAGTTCCCGGCGGACAAGATGGTGTCAGTCCTGGTGCAAGAAGGTCACGCCGTCTCAGACATGCTCCTGCCGCTGGATGGGGAACTC
GTCCTGGCTTCAGGAGCCGGATTCGGCGTCTCAGACGTGGGCTCGCACCTGGACTGTGGCGCGGGCGAACCTGCCGTCTTCCGCGACTCT
GACCGCTTCTCCTGGCATGACCCGCACCTGTGGCGCTCTGGGGACGAGGCACCTGGCCTCTTCTTCGTGGACGCCGAGCGCGTGCCCTGC
CGCCACGACGACGTCTTCTTTCCGCCTAGTGCCTCCTTCCGCGTGGGGCTCGGCCCTGGCGCTAGCCCCGTGCGTGTCCGCAGCATCTCG
GCTCTGGGCCGGACGTTCACGCGCGACGAGGACCTGGCTGTTTTCCTGGCGTCCCGCGCGGGCCGCCTACGCTTCCACGGGCCGGGCGCG
CTGAGCGTGGGCCCCGAGGACTGCGCGGACCCGTCGGGCTGCGTCTGCGGCAACGCGGAGGCGCAGCCGTGGATCTGCGCGGCCCTGCTC
CAGCCCCTGGGCGGCCGCTGCCCCCAGGCCGCCTGCCACAGCGCCCTCCGGCCCCAGGGGCAGTGCTGTGACCTCTGTGGAGCCGTTGTG
TTGCTGACCCACGGCCCCGCATTTGACCTGGAGCGGTACCGGGCGCGGATACTGGACACCTTCCTGGGTCTGCCTCAGTACCACGGGCTG
CAGGTGGCCGTGTCCAAGGTGCCACGCTCGTCCCGGCTCCGTGAGGCCGATACGGAGATCCAGGTGGTGCTGGTGGAGAATGGGCCCGAG
ACAGGCGGAGCGGGGCGGCTGGCCCGGGCCCTCCTGGCGGACGTCGCCGAGAACGGCGAGGCCCTCGGCGTCCTGGAGGCGACCATGCGG
GAGTCGGGCGCACACGTCTGGGGCAGCTCCGCGGCTGGGCTGGCGGGCGGCGTGGCGGCTGCCGTGCTGCTGGCGCTGCTGGTCCTGCTG
GTGGCGCCGCCGCTGCTGCGCCGCGCGGGGAGGCTCAGGTGGAGGAGGCACGAGGCGGCGGCCCCGGCTGGAGCGCCCCTCGGCTTCCGC
AACCCGGTGTTCGACGTGACGGCCTCCGAGGAGCTGCCCCTGCCGCGGCGGCTCAGCCTGGTTCCGAAGGCGGCCGCAGACAGCACCAGC
CACAGTTACTTCGTCAACCCTCTGTTCGCCGGGGCCGAGGCCGAGGCCTGAGCGGCCGCCTGACCGTCGACCTTGGGGCTCTCCACCCGC
TCTGGCCCCAGTCGAACTGGGGGCTAGCCACCTCCTCGTCCAGCCCCCAAACCTCCCCTTCCTTTCCCCCTCCTCCGGGGGCCAAGGACA
GGGTGGCCTTACTCAGTAAAGGTGTTTCCTGCACCTGCTGTCAGCCTGGCTATGCCGCCACCGGCCCCGCCCATGAGGACTAGGAGCCCA
GCCTTGCGCCGCATTCGCACTGGGGGACATGGGAGGGGTCTAGCTGGCCACTGCTGGAGGCAGCGCTGGTCGTCACCTGGGCGGCCAGAG
GCTGGGATCTGCGAAGTTGAACCCAGAACTAGGAGTGGGGCTTCCCCCGCCTTCCGGTGAGGGGAGGGTGAGGAGCTGGAGGGAGGGGCG
GGAGAGAGGCAAGGGGTGGACGGAGCCAAAGGCCGTGCCTGGTGGGGCGGACGGAAAAGGGGTGGGCATCCCTCCTGGTACCAAGCTGCT

>73321_73321_4_RCOR1-AMN_RCOR1_chr14_103059662_ENST00000570597_AMN_chr14_103390048_ENST00000299155_length(amino acids)=556AA_BP=17
MVEKGPEVSGKRRGRNNAAASASAAAASAAASAACASPAATAASGAAASSASAAAASAAAAPNNGQNKSLAAAAPNGNSSSNSWEEGSSG
SSSDEEHGGGGMRVGPQYQAVVPDFDPALTQAVSKLWVPNTDFDVAANWSQNRTPCAGGAVEFPADKMVSVLVQEGHAVSDMLLPLDGEL
VLASGAGFGVSDVGSHLDCGAGEPAVFRDSDRFSWHDPHLWRSGDEAPGLFFVDAERVPCRHDDVFFPPSASFRVGLGPGASPVRVRSIS
ALGRTFTRDEDLAVFLASRAGRLRFHGPGALSVGPEDCADPSGCVCGNAEAQPWICAALLQPLGGRCPQAACHSALRPQGQCCDLCGAVV
LLTHGPAFDLERYRARILDTFLGLPQYHGLQVAVSKVPRSSRLREADTEIQVVLVENGPETGGAGRLARALLADVAENGEALGVLEATMR
ESGAHVWGSSAAGLAGGVAAAVLLALLVLLVAPPLLRRAGRLRWRRHEAAAPAGAPLGFRNPVFDVTASEELPLPRRLSLVPKAAADSTS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for RCOR1-AMN

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	AMN	chr14:103059662	chr14:103390047	ENST00000299155		0	12	67_87	14.333333333333334	454.0	CUBN
Tgene	AMN	chr14:103059662	chr14:103390048	ENST00000299155		0	12	67_87	14.333333333333334	454.0	CUBN

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	RCOR1	chr14:103059662	chr14:103390047	ENST00000570597	+	2	12	78_257	117.33333333333333	483.0	HDAC1
Hgene	RCOR1	chr14:103059662	chr14:103390048	ENST00000570597	+	2	12	78_257	117.33333333333333	483.0	HDAC1
Hgene	RCOR1	chr14:103059662	chr14:103390047	ENST00000570597	+	2	12	296_384	117.33333333333333	483.0	KDM1A
Hgene	RCOR1	chr14:103059662	chr14:103390048	ENST00000570597	+	2	12	296_384	117.33333333333333	483.0	KDM1A

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for RCOR1-AMN

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for RCOR1-AMN

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source