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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ATAD1-RNLS (FusionGDB2 ID:7334)

Fusion Gene Summary for ATAD1-RNLS

Fusion gene summary

Fusion gene information	Fusion gene name: ATAD1-RNLS
	Fusion gene ID: 7334
		Hgene	Tgene
	Gene symbol	ATAD1	RNLS
	Gene ID	84896	55328
	Gene name	ATPase family AAA domain containing 1	renalase, FAD dependent amine oxidase
	Synonyms	AFDC1\|FNP001\|HKPX4\|Msp1\|THORASE	C10orf59\|RENALASE
	Cytomap	10q23.31	10q23.31
	Type of gene	protein-coding	protein-coding
	Description	ATPase family AAA domain-containing protein 1	renalaseMAO-Calpha-NAD(P)H oxidase/anomerasemonoamine oxidase-C
	Modification date	20200313	20200327
	UniProtAcc	Q8NBU5	.
	Ensembl transtripts involved in fusion gene	ENST00000308448, ENST00000328142, ENST00000541004, ENST00000495903, ENST00000400215,	ENST00000466945, ENST00000331772, ENST00000371947, ENST00000437752,
Fusion gene scores	* DoF score	11 X 8 X 7=616	8 X 7 X 5=280
	# samples	12	9
	** MAII score	log2(12/616*10)=-2.35989594508638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/280*10)=-1.63742992061529 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ATAD1 [Title/Abstract] AND RNLS [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ATAD1(89574195)-RNLS(90122482), # samples:3 RNLS(90332660)-ATAD1(89536184), # samples:1
Anticipated loss of major functional domain due to fusion event.	ATAD1-RNLS seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	RNLS	GO:0010459	negative regulation of heart rate	15841207
Tgene	RNLS	GO:0045776	negative regulation of blood pressure	15841207

Fusion gene breakpoints across ATAD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RNLS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUAD	TCGA-55-A48Y-01A	ATAD1	chr10	89574195	-	RNLS	chr10	90122482	-
ChimerDB4	LUAD	TCGA-55-A48Y	ATAD1	chr10	89574195	-	RNLS	chr10	90122482	-

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Fusion Gene ORF analysis for ATAD1-RNLS

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000308448	ENST00000466945	ATAD1	chr10	89574195	-	RNLS	chr10	90122482	-
5CDS-5UTR	ENST00000328142	ENST00000466945	ATAD1	chr10	89574195	-	RNLS	chr10	90122482	-
5CDS-5UTR	ENST00000541004	ENST00000466945	ATAD1	chr10	89574195	-	RNLS	chr10	90122482	-
5UTR-3CDS	ENST00000495903	ENST00000331772	ATAD1	chr10	89574195	-	RNLS	chr10	90122482	-
5UTR-3CDS	ENST00000495903	ENST00000371947	ATAD1	chr10	89574195	-	RNLS	chr10	90122482	-
5UTR-3CDS	ENST00000495903	ENST00000437752	ATAD1	chr10	89574195	-	RNLS	chr10	90122482	-
5UTR-5UTR	ENST00000495903	ENST00000466945	ATAD1	chr10	89574195	-	RNLS	chr10	90122482	-
Frame-shift	ENST00000328142	ENST00000331772	ATAD1	chr10	89574195	-	RNLS	chr10	90122482	-
Frame-shift	ENST00000328142	ENST00000371947	ATAD1	chr10	89574195	-	RNLS	chr10	90122482	-
Frame-shift	ENST00000328142	ENST00000437752	ATAD1	chr10	89574195	-	RNLS	chr10	90122482	-
In-frame	ENST00000308448	ENST00000331772	ATAD1	chr10	89574195	-	RNLS	chr10	90122482	-
In-frame	ENST00000308448	ENST00000371947	ATAD1	chr10	89574195	-	RNLS	chr10	90122482	-
In-frame	ENST00000308448	ENST00000437752	ATAD1	chr10	89574195	-	RNLS	chr10	90122482	-
In-frame	ENST00000541004	ENST00000331772	ATAD1	chr10	89574195	-	RNLS	chr10	90122482	-
In-frame	ENST00000541004	ENST00000371947	ATAD1	chr10	89574195	-	RNLS	chr10	90122482	-
In-frame	ENST00000541004	ENST00000437752	ATAD1	chr10	89574195	-	RNLS	chr10	90122482	-
intron-3CDS	ENST00000400215	ENST00000331772	ATAD1	chr10	89574195	-	RNLS	chr10	90122482	-
intron-3CDS	ENST00000400215	ENST00000371947	ATAD1	chr10	89574195	-	RNLS	chr10	90122482	-
intron-3CDS	ENST00000400215	ENST00000437752	ATAD1	chr10	89574195	-	RNLS	chr10	90122482	-
intron-5UTR	ENST00000400215	ENST00000466945	ATAD1	chr10	89574195	-	RNLS	chr10	90122482	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000308448	ATAD1	chr10	89574195	-	ENST00000371947	RNLS	chr10	90122482	-	2060	541	567	962	131
ENST00000308448	ATAD1	chr10	89574195	-	ENST00000437752	RNLS	chr10	90122482	-	963	541	567	962	131
ENST00000308448	ATAD1	chr10	89574195	-	ENST00000331772	RNLS	chr10	90122482	-	1439	541	567	1043	158
ENST00000541004	ATAD1	chr10	89574195	-	ENST00000371947	RNLS	chr10	90122482	-	2060	541	567	962	131
ENST00000541004	ATAD1	chr10	89574195	-	ENST00000437752	RNLS	chr10	90122482	-	963	541	567	962	131
ENST00000541004	ATAD1	chr10	89574195	-	ENST00000331772	RNLS	chr10	90122482	-	1439	541	567	1043	158

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000308448	ENST00000371947	ATAD1	chr10	89574195	-	RNLS	chr10	90122482	-	0.9493756	0.050624333
ENST00000308448	ENST00000437752	ATAD1	chr10	89574195	-	RNLS	chr10	90122482	-	0.35029963	0.6497004
ENST00000308448	ENST00000331772	ATAD1	chr10	89574195	-	RNLS	chr10	90122482	-	0.64043	0.35957003
ENST00000541004	ENST00000371947	ATAD1	chr10	89574195	-	RNLS	chr10	90122482	-	0.9493756	0.050624333
ENST00000541004	ENST00000437752	ATAD1	chr10	89574195	-	RNLS	chr10	90122482	-	0.35029963	0.6497004
ENST00000541004	ENST00000331772	ATAD1	chr10	89574195	-	RNLS	chr10	90122482	-	0.64043	0.35957003

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Fusion Genomic Features for ATAD1-RNLS

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ATAD1-RNLS

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:89574195/chr10:90122482)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ATAD1 Q8NBU5	.
FUNCTION: Outer mitochondrial translocase required to remove mislocalized tail-anchored transmembrane proteins on mitochondria (PubMed:24843043). Specifically recognizes and binds tail-anchored transmembrane proteins: acts as a dislocase that mediates the ATP-dependent extraction of mistargeted tail-anchored transmembrane proteins from the mitochondrion outer membrane (By similarity). Also plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory (By similarity). Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (By similarity). {ECO:0000250\|UniProtKB:P28737, ECO:0000250\|UniProtKB:Q9D5T0, ECO:0000269\|PubMed:24843043}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ATAD1

chr10:89574195

chr10:90122482

ENST00000308448

1_15

362.0

Topological domain

Mitochondrial intermembrane

Hgene

ATAD1

chr10:89574195

chr10:90122482

ENST00000328142

1_15

362.0

Topological domain

Mitochondrial intermembrane

Hgene

ATAD1

chr10:89574195

chr10:90122482

ENST00000541004

1_15

288.0

Topological domain

Mitochondrial intermembrane

Hgene

ATAD1

chr10:89574195

chr10:90122482

ENST00000308448

16_32

362.0

Transmembrane

Helical

Hgene

ATAD1

chr10:89574195

chr10:90122482

ENST00000328142

16_32

362.0

Transmembrane

Helical

Hgene

ATAD1

chr10:89574195

chr10:90122482

ENST00000541004

16_32

288.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ATAD1

chr10:89574195

chr10:90122482

ENST00000308448

133_140

362.0

Nucleotide binding

ATP

Hgene

ATAD1

chr10:89574195

chr10:90122482

ENST00000328142

133_140

362.0

Nucleotide binding

ATP

Hgene

ATAD1

chr10:89574195

chr10:90122482

ENST00000541004

133_140

288.0

Nucleotide binding

ATP

Hgene

ATAD1

chr10:89574195

chr10:90122482

ENST00000308448

33_361

362.0

Topological domain

Cytoplasmic

Hgene

ATAD1

chr10:89574195

chr10:90122482

ENST00000328142

33_361

362.0

Topological domain

Cytoplasmic

Hgene

ATAD1

chr10:89574195

chr10:90122482

ENST00000541004

33_361

288.0

Topological domain

Cytoplasmic

Tgene

RNLS

chr10:89574195

chr10:90122482

ENST00000331772

61_62

175

343.0

Region

Note=FAD-binding

Tgene

RNLS

chr10:89574195

chr10:90122482

ENST00000371947

61_62

175

316.0

Region

Note=FAD-binding

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Fusion Gene Sequence for ATAD1-RNLS

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>7334_7334_1_ATAD1-RNLS_ATAD1_chr10_89574195_ENST00000308448_RNLS_chr10_90122482_ENST00000331772_length(transcript)=1439nt_BP=541nt
AGCTGGTTCCCGTGGGGCCTCATGGGATGGTTGTCGTATCCTTCTGAGGTCCTTTAAGGACCGTCTCGGACCTGGGAACCCCCGGAGGAA
AGGTCACCCCGGTCTTCTCCCACGCCCTACCTCAGTGCCGCCCCCAAGCGCCCCGCAGCCCTTAGTATCTAGAGGATTAACCTCCAAGGG
CGTCCCGGGCCTCGCCTTGGCGTCCGGCCCGGCCTGGGCCCTTAGGGTCTGCTTAGCTCTTCCCCAAGACTCGTGCCATTCCCGAGGGAA
TCTTTGTCGGCATCCTGGTCACTGTGGGGGTTTGAGGTCGTCCCGGAAGACTTCAGAACCAGGCGAACCTAGACGAAGGCGGCTGGAATG
AACCAGGTTAACATTCAAGATGGTACATGCTGAAGCCTTTTCTCGTCCTTTGAGTCGGAATGAAGTTGTTGGTTTAATTTTCCGTTTGAC
AATATTTGGTGCAGTGACATACTTTACTATCAAATGGATGGTAGATGCAATTGATCCAACCAGAAAGCAAAAAGTAGAAGCTCAGAAACA
GTAATTAGTGAATGCCAAAGGCAGCAACTGGAGGCTGTGAGCTACTCCTCTCGATATGCTCTGGGCCTCTTTTATGAAGCTGGTACGAAG
ATTGATGTCCCTTGGGCTGGGCAGTACATCACCAGTAATCCCTGCATACGCTTCGTCTCCATTGATAATAAGAAGCGCAATATAGAGTCA
TCAGAAATTGGGCCTTCCCTCGTGATTCACACCACTGTCCCATTTGGAGTTACATACTTGGAACACAGCATTGAGGATGTGCAAGAGTTA
GTCTTCCAGCAGCTGGAAAACATTTTGCCGGGTTTGCCTCAGCCAATTGCTACCAAATGCCAAAAATGGAGACATTCACAGGTTACAAAT
GCTGCTGCCAACTGTCCTGGCCAAATGACTCTGCATCACAAACCTTTCCTTGCATGTGGAGGGGATGGATTTACTCAGTCCAACTTTGAT
GGCTGCATCACTTCTGCCCTATGTGTTCTGGAAGCTTTAAAGAATTATATTTAGTGCCTATATCCTTATTCTCTACATGTGTATTGGGTT
TTTATTTTCACAATTTTCTGTTATTGATTATTTTGTTTTCTATTTTGCTAAGAAAAATTACTGGAAAATTGTTCTTCACTTATTATCATT
TTTCATGTGGAGTATAAAATCAATTTTGTAATTTTGATAGTTACAACCCATGCTAGAATGGAAATTCCTCACACCTTGCACCTTCCCTAC
TTTTCTGAATTGCTATGACTACTCCTTGTTGGAGGAAAAGTGGTACTTAAAAAATAACAAACGACTCTCTCAAAAAAATTACATTAAATC

>7334_7334_1_ATAD1-RNLS_ATAD1_chr10_89574195_ENST00000308448_RNLS_chr10_90122482_ENST00000331772_length(amino acids)=158AA_BP=
MEAVSYSSRYALGLFYEAGTKIDVPWAGQYITSNPCIRFVSIDNKKRNIESSEIGPSLVIHTTVPFGVTYLEHSIEDVQELVFQQLENIL

--------------------------------------------------------------
>7334_7334_2_ATAD1-RNLS_ATAD1_chr10_89574195_ENST00000308448_RNLS_chr10_90122482_ENST00000371947_length(transcript)=2060nt_BP=541nt
AGCTGGTTCCCGTGGGGCCTCATGGGATGGTTGTCGTATCCTTCTGAGGTCCTTTAAGGACCGTCTCGGACCTGGGAACCCCCGGAGGAA
AGGTCACCCCGGTCTTCTCCCACGCCCTACCTCAGTGCCGCCCCCAAGCGCCCCGCAGCCCTTAGTATCTAGAGGATTAACCTCCAAGGG
CGTCCCGGGCCTCGCCTTGGCGTCCGGCCCGGCCTGGGCCCTTAGGGTCTGCTTAGCTCTTCCCCAAGACTCGTGCCATTCCCGAGGGAA
TCTTTGTCGGCATCCTGGTCACTGTGGGGGTTTGAGGTCGTCCCGGAAGACTTCAGAACCAGGCGAACCTAGACGAAGGCGGCTGGAATG
AACCAGGTTAACATTCAAGATGGTACATGCTGAAGCCTTTTCTCGTCCTTTGAGTCGGAATGAAGTTGTTGGTTTAATTTTCCGTTTGAC
AATATTTGGTGCAGTGACATACTTTACTATCAAATGGATGGTAGATGCAATTGATCCAACCAGAAAGCAAAAAGTAGAAGCTCAGAAACA
GTAATTAGTGAATGCCAAAGGCAGCAACTGGAGGCTGTGAGCTACTCCTCTCGATATGCTCTGGGCCTCTTTTATGAAGCTGGTACGAAG
ATTGATGTCCCTTGGGCTGGGCAGTACATCACCAGTAATCCCTGCATACGCTTCGTCTCCATTGATAATAAGAAGCGCAATATAGAGTCA
TCAGAAATTGGGCCTTCCCTCGTGATTCACACCACTGTCCCATTTGGAGTTACATACTTGGAACACAGCATTGAGGATGTGCAAGAGTTA
GTCTTCCAGCAGCTGGAAAACATTTTGCCGGGTTTGCCTCAGCCAATTGCTACCAAATGCCAAAAATGGAGACATTCACAGGTACCAAGT
GCTGGTGTGATTCTAGGATGTGCGAAGAGCCCCTGGATGATGGCGATTGGATTTCCCATCTGACTTCCTGGAAATTGGAGCACACAGTCA
GGTTTTATTTGATTTTTTTTTTTAAGGATACCACTTCACAGCCTTTAGGATAGCTATTATTTAGAAGCAAAACAGAAGATAAATGTTGGC
AAGGATGTGGAGATATTGGATTCCCTTGTGCAGTGCCGGTGGGAATGTAAAATGATGTAGCTACTATGGAAAATGATACGGCAATTTCTT
TAGAAATGAAATATAGAATTGCTGTATGATCTGCAGTTCCACATCTGGATATCTATCCAAAAGAAGTGAAAGTAGGGACTTGAACGAACA
TTTGTACACCAATGTTCACAGCGGCTTTATTCACAACAGCCAAAAGGTGGAAGCAACCCAGTGTCCATGGATAGATGAATAGATAAATAA
AATGTGGTATAAACATACAATGGGCTATTGTTTAGCCTTAAAAGGGAAGGAAATTCTGACATGCTGCAATATGGATGAAGCTTAAAGTCA
TTATGCAAAGTGGAATAAGCCTATCACAAAAAATAATATTACATAATTCTACTTATATGAGGAATCTAGAGCAGTCAGTTTCACAGAGAC
AGAAAATAGAATGGTGGTTGCCAAGGGCTGGGAGAAGAGGGCAATGGAGAGTGAGTGTTTAGTGGGTCAGAGTTTTAGTTTGGGAAGGTA
AAAAGTTCTGGAGATGGATGATGGTTATGGGTGCTCAACAGTGTGAATGTACTTAATGCCACAGAACTGCACATTTAAATGTGGTTAAAA
TCATCACTTTTATGTTATGTATATTTACCACAATAAATAAAGAAGTTGATATTTCTTATACTTACAAAGAGGAGAAGGGCATTTGCAAAT
CAACAAGAAGTGTGAGGCCCCTCTCTCTAGCAGAAAAATAGACTAAATCTATTTCTTTATCTTTTAACATCCTGTTTAAGGGAAATGCCA
AAACAAATGGGAAAAAATACACACACACAAATATATATGAACATGTTTTGCCTCATGAGTAATCAAAATGTGTACATATGTATGTTTATG

>7334_7334_2_ATAD1-RNLS_ATAD1_chr10_89574195_ENST00000308448_RNLS_chr10_90122482_ENST00000371947_length(amino acids)=131AA_BP=
MEAVSYSSRYALGLFYEAGTKIDVPWAGQYITSNPCIRFVSIDNKKRNIESSEIGPSLVIHTTVPFGVTYLEHSIEDVQELVFQQLENIL

--------------------------------------------------------------
>7334_7334_3_ATAD1-RNLS_ATAD1_chr10_89574195_ENST00000308448_RNLS_chr10_90122482_ENST00000437752_length(transcript)=963nt_BP=541nt
AGCTGGTTCCCGTGGGGCCTCATGGGATGGTTGTCGTATCCTTCTGAGGTCCTTTAAGGACCGTCTCGGACCTGGGAACCCCCGGAGGAA
AGGTCACCCCGGTCTTCTCCCACGCCCTACCTCAGTGCCGCCCCCAAGCGCCCCGCAGCCCTTAGTATCTAGAGGATTAACCTCCAAGGG
CGTCCCGGGCCTCGCCTTGGCGTCCGGCCCGGCCTGGGCCCTTAGGGTCTGCTTAGCTCTTCCCCAAGACTCGTGCCATTCCCGAGGGAA
TCTTTGTCGGCATCCTGGTCACTGTGGGGGTTTGAGGTCGTCCCGGAAGACTTCAGAACCAGGCGAACCTAGACGAAGGCGGCTGGAATG
AACCAGGTTAACATTCAAGATGGTACATGCTGAAGCCTTTTCTCGTCCTTTGAGTCGGAATGAAGTTGTTGGTTTAATTTTCCGTTTGAC
AATATTTGGTGCAGTGACATACTTTACTATCAAATGGATGGTAGATGCAATTGATCCAACCAGAAAGCAAAAAGTAGAAGCTCAGAAACA
GTAATTAGTGAATGCCAAAGGCAGCAACTGGAGGCTGTGAGCTACTCCTCTCGATATGCTCTGGGCCTCTTTTATGAAGCTGGTACGAAG
ATTGATGTCCCTTGGGCTGGGCAGTACATCACCAGTAATCCCTGCATACGCTTCGTCTCCATTGATAATAAGAAGCGCAATATAGAGTCA
TCAGAAATTGGGCCTTCCCTCGTGATTCACACCACTGTCCCATTTGGAGTTACATACTTGGAACACAGCATTGAGGATGTGCAAGAGTTA
GTCTTCCAGCAGCTGGAAAACATTTTGCCGGGTTTGCCTCAGCCAATTGCTACCAAATGCCAAAAATGGAGACATTCACAGGTACCAAGT

>7334_7334_3_ATAD1-RNLS_ATAD1_chr10_89574195_ENST00000308448_RNLS_chr10_90122482_ENST00000437752_length(amino acids)=131AA_BP=
MEAVSYSSRYALGLFYEAGTKIDVPWAGQYITSNPCIRFVSIDNKKRNIESSEIGPSLVIHTTVPFGVTYLEHSIEDVQELVFQQLENIL

--------------------------------------------------------------
>7334_7334_4_ATAD1-RNLS_ATAD1_chr10_89574195_ENST00000541004_RNLS_chr10_90122482_ENST00000331772_length(transcript)=1439nt_BP=541nt
AGCTGGTTCCCGTGGGGCCTCATGGGATGGTTGTCGTATCCTTCTGAGGTCCTTTAAGGACCGTCTCGGACCTGGGAACCCCCGGAGGAA
AGGTCACCCCGGTCTTCTCCCACGCCCTACCTCAGTGCCGCCCCCAAGCGCCCCGCAGCCCTTAGTATCTAGAGGATTAACCTCCAAGGG
CGTCCCGGGCCTCGCCTTGGCGTCCGGCCCGGCCTGGGCCCTTAGGGTCTGCTTAGCTCTTCCCCAAGACTCGTGCCATTCCCGAGGGAA
TCTTTGTCGGCATCCTGGTCACTGTGGGGGTTTGAGGTCGTCCCGGAAGACTTCAGAACCAGGCGAACCTAGACGAAGGCGGCTGGAATG
AACCAGGTTAACATTCAAGATGGTACATGCTGAAGCCTTTTCTCGTCCTTTGAGTCGGAATGAAGTTGTTGGTTTAATTTTCCGTTTGAC
AATATTTGGTGCAGTGACATACTTTACTATCAAATGGATGGTAGATGCAATTGATCCAACCAGAAAGCAAAAAGTAGAAGCTCAGAAACA
GTAATTAGTGAATGCCAAAGGCAGCAACTGGAGGCTGTGAGCTACTCCTCTCGATATGCTCTGGGCCTCTTTTATGAAGCTGGTACGAAG
ATTGATGTCCCTTGGGCTGGGCAGTACATCACCAGTAATCCCTGCATACGCTTCGTCTCCATTGATAATAAGAAGCGCAATATAGAGTCA
TCAGAAATTGGGCCTTCCCTCGTGATTCACACCACTGTCCCATTTGGAGTTACATACTTGGAACACAGCATTGAGGATGTGCAAGAGTTA
GTCTTCCAGCAGCTGGAAAACATTTTGCCGGGTTTGCCTCAGCCAATTGCTACCAAATGCCAAAAATGGAGACATTCACAGGTTACAAAT
GCTGCTGCCAACTGTCCTGGCCAAATGACTCTGCATCACAAACCTTTCCTTGCATGTGGAGGGGATGGATTTACTCAGTCCAACTTTGAT
GGCTGCATCACTTCTGCCCTATGTGTTCTGGAAGCTTTAAAGAATTATATTTAGTGCCTATATCCTTATTCTCTACATGTGTATTGGGTT
TTTATTTTCACAATTTTCTGTTATTGATTATTTTGTTTTCTATTTTGCTAAGAAAAATTACTGGAAAATTGTTCTTCACTTATTATCATT
TTTCATGTGGAGTATAAAATCAATTTTGTAATTTTGATAGTTACAACCCATGCTAGAATGGAAATTCCTCACACCTTGCACCTTCCCTAC
TTTTCTGAATTGCTATGACTACTCCTTGTTGGAGGAAAAGTGGTACTTAAAAAATAACAAACGACTCTCTCAAAAAAATTACATTAAATC

>7334_7334_4_ATAD1-RNLS_ATAD1_chr10_89574195_ENST00000541004_RNLS_chr10_90122482_ENST00000331772_length(amino acids)=158AA_BP=
MEAVSYSSRYALGLFYEAGTKIDVPWAGQYITSNPCIRFVSIDNKKRNIESSEIGPSLVIHTTVPFGVTYLEHSIEDVQELVFQQLENIL

--------------------------------------------------------------
>7334_7334_5_ATAD1-RNLS_ATAD1_chr10_89574195_ENST00000541004_RNLS_chr10_90122482_ENST00000371947_length(transcript)=2060nt_BP=541nt
AGCTGGTTCCCGTGGGGCCTCATGGGATGGTTGTCGTATCCTTCTGAGGTCCTTTAAGGACCGTCTCGGACCTGGGAACCCCCGGAGGAA
AGGTCACCCCGGTCTTCTCCCACGCCCTACCTCAGTGCCGCCCCCAAGCGCCCCGCAGCCCTTAGTATCTAGAGGATTAACCTCCAAGGG
CGTCCCGGGCCTCGCCTTGGCGTCCGGCCCGGCCTGGGCCCTTAGGGTCTGCTTAGCTCTTCCCCAAGACTCGTGCCATTCCCGAGGGAA
TCTTTGTCGGCATCCTGGTCACTGTGGGGGTTTGAGGTCGTCCCGGAAGACTTCAGAACCAGGCGAACCTAGACGAAGGCGGCTGGAATG
AACCAGGTTAACATTCAAGATGGTACATGCTGAAGCCTTTTCTCGTCCTTTGAGTCGGAATGAAGTTGTTGGTTTAATTTTCCGTTTGAC
AATATTTGGTGCAGTGACATACTTTACTATCAAATGGATGGTAGATGCAATTGATCCAACCAGAAAGCAAAAAGTAGAAGCTCAGAAACA
GTAATTAGTGAATGCCAAAGGCAGCAACTGGAGGCTGTGAGCTACTCCTCTCGATATGCTCTGGGCCTCTTTTATGAAGCTGGTACGAAG
ATTGATGTCCCTTGGGCTGGGCAGTACATCACCAGTAATCCCTGCATACGCTTCGTCTCCATTGATAATAAGAAGCGCAATATAGAGTCA
TCAGAAATTGGGCCTTCCCTCGTGATTCACACCACTGTCCCATTTGGAGTTACATACTTGGAACACAGCATTGAGGATGTGCAAGAGTTA
GTCTTCCAGCAGCTGGAAAACATTTTGCCGGGTTTGCCTCAGCCAATTGCTACCAAATGCCAAAAATGGAGACATTCACAGGTACCAAGT
GCTGGTGTGATTCTAGGATGTGCGAAGAGCCCCTGGATGATGGCGATTGGATTTCCCATCTGACTTCCTGGAAATTGGAGCACACAGTCA
GGTTTTATTTGATTTTTTTTTTTAAGGATACCACTTCACAGCCTTTAGGATAGCTATTATTTAGAAGCAAAACAGAAGATAAATGTTGGC
AAGGATGTGGAGATATTGGATTCCCTTGTGCAGTGCCGGTGGGAATGTAAAATGATGTAGCTACTATGGAAAATGATACGGCAATTTCTT
TAGAAATGAAATATAGAATTGCTGTATGATCTGCAGTTCCACATCTGGATATCTATCCAAAAGAAGTGAAAGTAGGGACTTGAACGAACA
TTTGTACACCAATGTTCACAGCGGCTTTATTCACAACAGCCAAAAGGTGGAAGCAACCCAGTGTCCATGGATAGATGAATAGATAAATAA
AATGTGGTATAAACATACAATGGGCTATTGTTTAGCCTTAAAAGGGAAGGAAATTCTGACATGCTGCAATATGGATGAAGCTTAAAGTCA
TTATGCAAAGTGGAATAAGCCTATCACAAAAAATAATATTACATAATTCTACTTATATGAGGAATCTAGAGCAGTCAGTTTCACAGAGAC
AGAAAATAGAATGGTGGTTGCCAAGGGCTGGGAGAAGAGGGCAATGGAGAGTGAGTGTTTAGTGGGTCAGAGTTTTAGTTTGGGAAGGTA
AAAAGTTCTGGAGATGGATGATGGTTATGGGTGCTCAACAGTGTGAATGTACTTAATGCCACAGAACTGCACATTTAAATGTGGTTAAAA
TCATCACTTTTATGTTATGTATATTTACCACAATAAATAAAGAAGTTGATATTTCTTATACTTACAAAGAGGAGAAGGGCATTTGCAAAT
CAACAAGAAGTGTGAGGCCCCTCTCTCTAGCAGAAAAATAGACTAAATCTATTTCTTTATCTTTTAACATCCTGTTTAAGGGAAATGCCA
AAACAAATGGGAAAAAATACACACACACAAATATATATGAACATGTTTTGCCTCATGAGTAATCAAAATGTGTACATATGTATGTTTATG

>7334_7334_5_ATAD1-RNLS_ATAD1_chr10_89574195_ENST00000541004_RNLS_chr10_90122482_ENST00000371947_length(amino acids)=131AA_BP=
MEAVSYSSRYALGLFYEAGTKIDVPWAGQYITSNPCIRFVSIDNKKRNIESSEIGPSLVIHTTVPFGVTYLEHSIEDVQELVFQQLENIL

--------------------------------------------------------------
>7334_7334_6_ATAD1-RNLS_ATAD1_chr10_89574195_ENST00000541004_RNLS_chr10_90122482_ENST00000437752_length(transcript)=963nt_BP=541nt
AGCTGGTTCCCGTGGGGCCTCATGGGATGGTTGTCGTATCCTTCTGAGGTCCTTTAAGGACCGTCTCGGACCTGGGAACCCCCGGAGGAA
AGGTCACCCCGGTCTTCTCCCACGCCCTACCTCAGTGCCGCCCCCAAGCGCCCCGCAGCCCTTAGTATCTAGAGGATTAACCTCCAAGGG
CGTCCCGGGCCTCGCCTTGGCGTCCGGCCCGGCCTGGGCCCTTAGGGTCTGCTTAGCTCTTCCCCAAGACTCGTGCCATTCCCGAGGGAA
TCTTTGTCGGCATCCTGGTCACTGTGGGGGTTTGAGGTCGTCCCGGAAGACTTCAGAACCAGGCGAACCTAGACGAAGGCGGCTGGAATG
AACCAGGTTAACATTCAAGATGGTACATGCTGAAGCCTTTTCTCGTCCTTTGAGTCGGAATGAAGTTGTTGGTTTAATTTTCCGTTTGAC
AATATTTGGTGCAGTGACATACTTTACTATCAAATGGATGGTAGATGCAATTGATCCAACCAGAAAGCAAAAAGTAGAAGCTCAGAAACA
GTAATTAGTGAATGCCAAAGGCAGCAACTGGAGGCTGTGAGCTACTCCTCTCGATATGCTCTGGGCCTCTTTTATGAAGCTGGTACGAAG
ATTGATGTCCCTTGGGCTGGGCAGTACATCACCAGTAATCCCTGCATACGCTTCGTCTCCATTGATAATAAGAAGCGCAATATAGAGTCA
TCAGAAATTGGGCCTTCCCTCGTGATTCACACCACTGTCCCATTTGGAGTTACATACTTGGAACACAGCATTGAGGATGTGCAAGAGTTA
GTCTTCCAGCAGCTGGAAAACATTTTGCCGGGTTTGCCTCAGCCAATTGCTACCAAATGCCAAAAATGGAGACATTCACAGGTACCAAGT

>7334_7334_6_ATAD1-RNLS_ATAD1_chr10_89574195_ENST00000541004_RNLS_chr10_90122482_ENST00000437752_length(amino acids)=131AA_BP=
MEAVSYSSRYALGLFYEAGTKIDVPWAGQYITSNPCIRFVSIDNKKRNIESSEIGPSLVIHTTVPFGVTYLEHSIEDVQELVFQQLENIL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ATAD1-RNLS

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ATAD1-RNLS

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for ATAD1-RNLS

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source