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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RECK-KDM4C (FusionGDB2 ID:73370)

Fusion Gene Summary for RECK-KDM4C

check button Fusion gene summary
Fusion gene informationFusion gene name: RECK-KDM4C
Fusion gene ID: 73370
HgeneTgene
Gene symbol

RECK

KDM4C

Gene ID

8434

23081

Gene namereversion inducing cysteine rich protein with kazal motifslysine demethylase 4C
SynonymsST15GASC1|JHDM3C|JMJD2C|TDRD14C
Cytomap

9p13.3

9p24.1

Type of geneprotein-codingprotein-coding
Descriptionreversion-inducing cysteine-rich protein with Kazal motifsmembrane-anchored glycoprotein (metastasis and invasion)suppression of tumorigenicity 15 (reversion-inducing-cysteine-rich protein with kazal motifs)suppression of tumorigenicity 5 (reversion-inlysine-specific demethylase 4CJmjC domain-containing histone demethylation protein 3Cgene amplified in squamous cell carcinoma 1 proteinjumonji domain-containing protein 2Clysine (K)-specific demethylase 4Ctudor domain containing 14C
Modification date2020032220200329
UniProtAcc.

Q9H3R0

Ensembl transtripts involved in fusion geneENST00000479053, ENST00000377966, 
ENST00000381306, ENST00000381309, 
ENST00000442236, ENST00000535193, 
ENST00000543771, ENST00000428870, 
ENST00000401787, ENST00000489243, 
ENST00000536108, 
Fusion gene scores* DoF score9 X 7 X 6=37822 X 22 X 7=3388
# samples 1026
** MAII scorelog2(10/378*10)=-1.91838623444635
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(26/3388*10)=-3.70385034630374
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RECK [Title/Abstract] AND KDM4C [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRECK(36065621)-KDM4C(6980924), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRECK

GO:1904684

negative regulation of metalloendopeptidase activity

18194466

TgeneKDM4C

GO:0006357

regulation of transcription by RNA polymerase II

17277772

TgeneKDM4C

GO:0033169

histone H3-K9 demethylation

18066052|21914792

TgeneKDM4C

GO:0070544

histone H3-K36 demethylation

21914792


check buttonFusion gene breakpoints across RECK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KDM4C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer265NRECKchr9

36065621

+KDM4Cchr9

6980924

+


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Fusion Gene ORF analysis for RECK-KDM4C

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000479053ENST00000381306RECKchr9

36065621

+KDM4Cchr9

6980924

+
3UTR-3CDSENST00000479053ENST00000381309RECKchr9

36065621

+KDM4Cchr9

6980924

+
3UTR-3CDSENST00000479053ENST00000442236RECKchr9

36065621

+KDM4Cchr9

6980924

+
3UTR-3CDSENST00000479053ENST00000535193RECKchr9

36065621

+KDM4Cchr9

6980924

+
3UTR-3CDSENST00000479053ENST00000543771RECKchr9

36065621

+KDM4Cchr9

6980924

+
3UTR-5UTRENST00000479053ENST00000428870RECKchr9

36065621

+KDM4Cchr9

6980924

+
3UTR-intronENST00000479053ENST00000401787RECKchr9

36065621

+KDM4Cchr9

6980924

+
3UTR-intronENST00000479053ENST00000489243RECKchr9

36065621

+KDM4Cchr9

6980924

+
3UTR-intronENST00000479053ENST00000536108RECKchr9

36065621

+KDM4Cchr9

6980924

+
5CDS-5UTRENST00000377966ENST00000428870RECKchr9

36065621

+KDM4Cchr9

6980924

+
5CDS-intronENST00000377966ENST00000401787RECKchr9

36065621

+KDM4Cchr9

6980924

+
5CDS-intronENST00000377966ENST00000489243RECKchr9

36065621

+KDM4Cchr9

6980924

+
5CDS-intronENST00000377966ENST00000536108RECKchr9

36065621

+KDM4Cchr9

6980924

+
In-frameENST00000377966ENST00000381306RECKchr9

36065621

+KDM4Cchr9

6980924

+
In-frameENST00000377966ENST00000381309RECKchr9

36065621

+KDM4Cchr9

6980924

+
In-frameENST00000377966ENST00000442236RECKchr9

36065621

+KDM4Cchr9

6980924

+
In-frameENST00000377966ENST00000535193RECKchr9

36065621

+KDM4Cchr9

6980924

+
In-frameENST00000377966ENST00000543771RECKchr9

36065621

+KDM4Cchr9

6980924

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000377966RECKchr936065621+ENST00000535193KDM4Cchr96980924+33039714642491675
ENST00000377966RECKchr936065621+ENST00000543771KDM4Cchr96980924+33039714642491675
ENST00000377966RECKchr936065621+ENST00000381306KDM4Cchr96980924+40869714643193909
ENST00000377966RECKchr936065621+ENST00000381309KDM4Cchr96980924+41409714643220918
ENST00000377966RECKchr936065621+ENST00000442236KDM4Cchr96980924+30949714642998844

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000377966ENST00000535193RECKchr936065621+KDM4Cchr96980924+0.0030924690.99690753
ENST00000377966ENST00000543771RECKchr936065621+KDM4Cchr96980924+0.0030924690.99690753
ENST00000377966ENST00000381306RECKchr936065621+KDM4Cchr96980924+0.0003973570.9996026
ENST00000377966ENST00000381309RECKchr936065621+KDM4Cchr96980924+0.0003964990.99960357
ENST00000377966ENST00000442236RECKchr936065621+KDM4Cchr96980924+0.0018657360.9981343

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Fusion Genomic Features for RECK-KDM4C


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RECKchr936065621+KDM4Cchr96980924+0.593584060.406416
RECKchr936065621+KDM4Cchr96980924+0.593584060.406416

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for RECK-KDM4C


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:36065621/chr9:6980924)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.KDM4C

Q9H3R0

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. {ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:28262558}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRECKchr9:36065621chr9:6980924ENST00000377966+62137_84135972.0RepeatNote=Knot 1
TgeneKDM4Cchr9:36065621chr9:6980924ENST00000381306721877_9343071048.0DomainNote=Tudor 1
TgeneKDM4Cchr9:36065621chr9:6980924ENST00000381306721935_9913071048.0DomainNote=Tudor 2
TgeneKDM4Cchr9:36065621chr9:6980924ENST00000381309722877_9343071057.0DomainNote=Tudor 1
TgeneKDM4Cchr9:36065621chr9:6980924ENST00000381309722935_9913071057.0DomainNote=Tudor 2
TgeneKDM4Cchr9:36065621chr9:6980924ENST00000535193718877_934329836.0DomainNote=Tudor 1
TgeneKDM4Cchr9:36065621chr9:6980924ENST00000535193718935_991329836.0DomainNote=Tudor 2
TgeneKDM4Cchr9:36065621chr9:6980924ENST00000543771718877_934307814.0DomainNote=Tudor 1
TgeneKDM4Cchr9:36065621chr9:6980924ENST00000543771718935_991307814.0DomainNote=Tudor 2
TgeneKDM4Cchr9:36065621chr9:6980924ENST00000381306721689_7473071048.0Zinc fingerNote=PHD-type 1
TgeneKDM4Cchr9:36065621chr9:6980924ENST00000381306721752_7853071048.0Zinc fingerC2HC pre-PHD-type
TgeneKDM4Cchr9:36065621chr9:6980924ENST00000381306721808_8653071048.0Zinc fingerPHD-type 2
TgeneKDM4Cchr9:36065621chr9:6980924ENST00000381309722689_7473071057.0Zinc fingerNote=PHD-type 1
TgeneKDM4Cchr9:36065621chr9:6980924ENST00000381309722752_7853071057.0Zinc fingerC2HC pre-PHD-type
TgeneKDM4Cchr9:36065621chr9:6980924ENST00000381309722808_8653071057.0Zinc fingerPHD-type 2
TgeneKDM4Cchr9:36065621chr9:6980924ENST00000535193718689_747329836.0Zinc fingerNote=PHD-type 1
TgeneKDM4Cchr9:36065621chr9:6980924ENST00000535193718752_785329836.0Zinc fingerC2HC pre-PHD-type
TgeneKDM4Cchr9:36065621chr9:6980924ENST00000535193718808_865329836.0Zinc fingerPHD-type 2
TgeneKDM4Cchr9:36065621chr9:6980924ENST00000543771718689_747307814.0Zinc fingerNote=PHD-type 1
TgeneKDM4Cchr9:36065621chr9:6980924ENST00000543771718752_785307814.0Zinc fingerC2HC pre-PHD-type
TgeneKDM4Cchr9:36065621chr9:6980924ENST00000543771718808_865307814.0Zinc fingerPHD-type 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRECKchr9:36065621chr9:6980924ENST00000377966+621627_673135972.0DomainKazal-like 1
HgeneRECKchr9:36065621chr9:6980924ENST00000377966+621698_752135972.0DomainKazal-like 2
HgeneRECKchr9:36065621chr9:6980924ENST00000377966+621753_789135972.0DomainKazal-like 3
HgeneRECKchr9:36065621chr9:6980924ENST00000377966+62137_338135972.0RegionNote=5 X Knot repeats
HgeneRECKchr9:36065621chr9:6980924ENST00000377966+621104_141135972.0RepeatNote=Knot 2
HgeneRECKchr9:36065621chr9:6980924ENST00000377966+621151_197135972.0RepeatNote=Knot 3
HgeneRECKchr9:36065621chr9:6980924ENST00000377966+621216_263135972.0RepeatNote=Knot 4
HgeneRECKchr9:36065621chr9:6980924ENST00000377966+621292_338135972.0RepeatNote=Knot 5
TgeneKDM4Cchr9:36065621chr9:6980924ENST00000381306721144_3103071048.0DomainJmjC
TgeneKDM4Cchr9:36065621chr9:6980924ENST0000038130672116_583071048.0DomainJmjN
TgeneKDM4Cchr9:36065621chr9:6980924ENST00000381309722144_3103071057.0DomainJmjC
TgeneKDM4Cchr9:36065621chr9:6980924ENST0000038130972216_583071057.0DomainJmjN
TgeneKDM4Cchr9:36065621chr9:6980924ENST00000535193718144_310329836.0DomainJmjC
TgeneKDM4Cchr9:36065621chr9:6980924ENST0000053519371816_58329836.0DomainJmjN
TgeneKDM4Cchr9:36065621chr9:6980924ENST00000543771718144_310307814.0DomainJmjC
TgeneKDM4Cchr9:36065621chr9:6980924ENST0000054377171816_58307814.0DomainJmjN


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Fusion Gene Sequence for RECK-KDM4C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>73370_73370_1_RECK-KDM4C_RECK_chr9_36065621_ENST00000377966_KDM4C_chr9_6980924_ENST00000381306_length(transcript)=4086nt_BP=971nt
GATGAACCCTTGTCAGGGGGCCGTGTCTGCGGGAGGCCGAAGGATCCCGGGTGACATGCTTTCTTTGGGTGCGAGGCAGCGTCTCGGCAG
AAAGAATATTGCGAGTATTACTGAGGGTACATGAAGGAGAGAAGCCCCTTTGGTTCGGCCTTGGACTAAGCCCTTGTTCTCAGGTGAACT
TGCAGTGTGATCTTGAGTAAGGTCAGTCTCCTCTCTCACCTCAGTGGCCCGAAACCTCAGGAGGTGGCAGAGGTTTTCTAATGACTCTCC
CAGCTCTGACATCCTCTGACTTCACTCTGGGAGAACGTGGGCTGGTGGACTCCTGGCAGAAGCCGACACACAGTTGGGCCATAACAAAGA
GCCCTGGTACGGGGCACGTTCCCGCCCCCGGGAGGTTTTGGAAACACTGTGAGGCAGGGGGCGGGGCTTGAGCGGGCCGCAGCCAGTCAC
CAAAGGGCCGGGCGCTGGGGGCGGGGCCTCGCGCGAGCGGCGGCGGTAGCGGCGGCAGCGGCTGCGGCCAAGCTGGGTCCGAGCATCCCG
CGGCTCTGGAGCCGCCCGGCCCGGACATGGCGACCGTCCGGGCCTCTCTGCGAGGTGCGCTGCTCCTTCTGCTGGCCGTGGCGGGGGTCG
CGGAGGTGGCAGGGGGCCTGGCTCCGGGCAGTGCGGGTGCATTGTGTTGTAATCATTCAAAGGATAACCAAATGTGCCGTGATGTATGTG
AACAGATTTTCTCCTCAAAAAGTGAATCCCGACTAAAACATCTGTTGCAGCGAGCCCCAGATTATTGCCCAGAGACAATGGTTGAAATTT
GGAATTGTATGAATTCATCTTTGCCAGGTGTGTTTAAGAAGTCTGATGGCTGGGTTGGCTTAGGCTGCTGTGAACTGGCTATTGCCTTGG
AGTGTCGACAGGCATGCAAGCAGGCATCTTCAAAGAATGATATTTCCAAAGTTTGCAGAAAAGAATATGAGTGCACTTGCAGGAAAGACA
TGGTGAAGATTTCAATGGATATCTTTGTGAGGAAATTTCAGCCAGACAGATATCAGCTTTGGAAACAAGGAAAGGATATATACACCATTG
ATCACACGAAGCCTACTCCAGCATCCACCCCTGAAGTAAAAGCATGGCTGCAGAGGAGGAGGAAAGTAAGAAAAGCATCCCGAAGCTTCC
AGTGTGCTAGGTCTACCTCTAAAAGGCCTAAGGCTGATGAGGAAGAGGAAGTGTCAGATGAAGTCGATGGGGCAGAGGTCCCTAACCCCG
ACTCAGTCACAGATGACCTCAAGGTCAGTGAAAAGTCAGAAGCAGCAGTGAAGCTGAGGAACACAGAAGCATCTTCAGAAGAAGAGTCAT
CTGCTAGCAGGATGCAGGTGGAGCAGAATTTATCAGATCATATCAAACTCTCAGGAAACAGCTGCTTAAGTACATCTGTAACAGAAGACA
TAAAAACTGAGGATGACAAAGCTTATGCATATAGAAGTGTACCTTCTATATCCAGTGAGGCTGATGATTCCATTCCATTGTCTAGTGGCT
ATGAGAAGCCCGAGAAATCAGACCCATCCGAGCTTTCATGGCCAAAGTCACCTGAGTCATGCTCATCAGTGGCAGAGAGTAATGGTGTGT
TAACAGAGGGAGAAGAGAGTGATGTGGAGAGCCATGGGAATGGCCTTGAACCTGGGGAAATCCCAGCGGTCCCCAGTGGAGAGAGAAATA
GCTTCAAAGTCCCCAGTATAGCAGAGGGAGAGAACAAAACCTCTAAGAGTTGGCGCCATCCACTTAGCAGGCCTCCAGCAAGATCTCCGA
TGACTCTTGTGAAGCAGCAGGCGCCAAGTGATGAAGAATTGCCTGAGGTTCTGTCCATTGAGGAGGAAGTGGAAGAAACAGAGTCTTGGG
CGAAACCTCTCATCCACCTTTGGCAGACGAAGTCCCCTAACTTCGCAGCTGAGCAAGAGTATAATGCAACAGTGGCCAGGATGAAGCCAC
ACTGTGCCATCTGCACTCTGCTCATGCCGTACCACAAGCCAGATAGCAGCAATGAAGAAAATGATGCTAGATGGGAGACAAAATTAGATG
AAGTCGTTACATCGGAGGGAAAGACTAAGCCCCTCATACCAGAGATGTGTTTTATTTATAGTGAAGAAAATATAGAATATTCTCCACCCA
ATGCCTTCCTTGAAGAGGATGGAACAAGTCTCCTTATTTCCTGTGCAAAGTGCTGCGTACGGGTTCATGCAAGTTGTTATGGTATTCCTT
CTCATGAGATCTGTGATGGATGGCTGTGTGCCCGGTGCAAAAGAAATGCGTGGACAGCAGAATGCTGTCTCTGCAATTTGAGAGGAGGTG
CTCTTAAGCAAACGAAGAACAATAAGTGGGCCCATGTCATGTGCGCCGTTGCGGTCCCAGAAGTTCGATTCACTAATGTCCCAGAAAGGA
CACAAATAGATGTAGGCAGAATACCTTTACAGAGGTTAAAATTGAAATGCATCTTCTGCAGACACCGGGTTAAGAGGGTCTCTGGAGCCT
GCATCCAGTGTTCCTACGGTCGCTGCCCGGCCTCCTTCCATGTCACTTGTGCCCATGCTGCTGGGGTACTGATGGAGCCTGATGACTGGC
CTTATGTGGTGAACATTACATGCTTTCGACATAAGGTCAACCCCAACGTGAAGTCCAAGGCTTGCGAGAAGGTCATTTCCGTGGGTCAAA
CGGTCATCACGAAGCATCGGAACACCCGGTATTACAGTTGCAGAGTGATGGCTGTGACATCGCAGACCTTCTATGAGGTCATGTTTGATG
ATGGCTCCTTTAGCAGAGACACATTTCCTGAGGATATCGTGAGCCGAGACTGTCTGAAGCTGGGCCCACCTGCTGAGGGAGAAGTCGTCC
AAGTCAAGTGGCCCGATGGCAAACTCTATGGAGCAAAATATTTTGGATCAAATATTGCCCACATGTACCAGGTTGAGTTTGAAGATGGAT
CCCAGATAGCAATGAAGAGAGAGGACATCTACACTTTAGATGAAGAGTTACCCAAGAGAGTGAAAGCTCGATTTGTAAGTGCTGGCAGAT
GCCACTTGGGGACCTGCCAAGTGAATTCCTTGTCCTCACCTCATGTTTCCCAAGCCCAGCAGGAAACATACTTGGGCTTTTGGATTAATT
CTAAAAAAAGCCAATGCAACATTTTCCTTAGTGGAACCTATTGAATGCAAACTTCAAATTCAACCAAAATCGGGGAAATTAATGCATGTG
CTTTACTTTTCTTCTAATGAAGTCACATGATGCTTCTTTGTGTTGACATTTATTGGTGCACAAAAATACTTACTGAATGTGTGCTCTGTG
TAAAACACCAGGAGCAAACAAAGATACCATCAAGGCATTTGCAATCTTGTTAGTAGAAGCAACATTAAAAGTATTCAGGAGTAGATCAAA
GGGGACTCGGCATAATTGAATGTCTGTCTATTCTTTTATAGGTTTTTCATGGATTGACTACCTTCTGTCTCAGAAAGTTACTGATGTTTG
TGTCAGTTCATCATTAAGCTAAACTCTGACTTTCATAATAAAAGGGATAAACAAAGCCTAAATGCTAGTTGTGGGAATACTAAAGCAGTT
TTTTAAAAAGGAAATAGTAGTTTCATGCCCTCACATACCATTAAAAGATGAACAAACATGGACAAATATTCAAAACTGCAGTCATTGAAA
AATATAATTCACAATAATTTAGACTTCATATTATTGTATCATAAAATATTCAGTGGACCCTGAAATGAAGTCAGTTTTATTCATTTAGAA
TTATATCTATTGTGTCTGTGAAATGATAAATCCTAAATAGAGAAATTTGAATGGATGGGGTTTTTCTGACTAAAATGAAATTTTTTTTCT
GAATAATTCAGTTTAGTGAGTGCTTATGATATACTTGTCTGCAGTGATAGAGTCACTATAGATTATTTGGTTATTTTGGAAAAACCAAGG
GTTTTCTTAAATCAGGGATGTCCAATCTTTTTGCATCCCTGGGCCATACTTGAAGAAGAAGAATTGTCTTTGGCCTCACATAAACTACAC

>73370_73370_1_RECK-KDM4C_RECK_chr9_36065621_ENST00000377966_KDM4C_chr9_6980924_ENST00000381306_length(amino acids)=909AA_BP=169
MGAGPRASGGGSGGSGCGQAGSEHPAALEPPGPDMATVRASLRGALLLLLAVAGVAEVAGGLAPGSAGALCCNHSKDNQMCRDVCEQIFS
SKSESRLKHLLQRAPDYCPETMVEIWNCMNSSLPGVFKKSDGWVGLGCCELAIALECRQACKQASSKNDISKVCRKEYECTCRKDMVKIS
MDIFVRKFQPDRYQLWKQGKDIYTIDHTKPTPASTPEVKAWLQRRRKVRKASRSFQCARSTSKRPKADEEEEVSDEVDGAEVPNPDSVTD
DLKVSEKSEAAVKLRNTEASSEEESSASRMQVEQNLSDHIKLSGNSCLSTSVTEDIKTEDDKAYAYRSVPSISSEADDSIPLSSGYEKPE
KSDPSELSWPKSPESCSSVAESNGVLTEGEESDVESHGNGLEPGEIPAVPSGERNSFKVPSIAEGENKTSKSWRHPLSRPPARSPMTLVK
QQAPSDEELPEVLSIEEEVEETESWAKPLIHLWQTKSPNFAAEQEYNATVARMKPHCAICTLLMPYHKPDSSNEENDARWETKLDEVVTS
EGKTKPLIPEMCFIYSEENIEYSPPNAFLEEDGTSLLISCAKCCVRVHASCYGIPSHEICDGWLCARCKRNAWTAECCLCNLRGGALKQT
KNNKWAHVMCAVAVPEVRFTNVPERTQIDVGRIPLQRLKLKCIFCRHRVKRVSGACIQCSYGRCPASFHVTCAHAAGVLMEPDDWPYVVN
ITCFRHKVNPNVKSKACEKVISVGQTVITKHRNTRYYSCRVMAVTSQTFYEVMFDDGSFSRDTFPEDIVSRDCLKLGPPAEGEVVQVKWP
DGKLYGAKYFGSNIAHMYQVEFEDGSQIAMKREDIYTLDEELPKRVKARFVSAGRCHLGTCQVNSLSSPHVSQAQQETYLGFWINSKKSQ

--------------------------------------------------------------
>73370_73370_2_RECK-KDM4C_RECK_chr9_36065621_ENST00000377966_KDM4C_chr9_6980924_ENST00000381309_length(transcript)=4140nt_BP=971nt
GATGAACCCTTGTCAGGGGGCCGTGTCTGCGGGAGGCCGAAGGATCCCGGGTGACATGCTTTCTTTGGGTGCGAGGCAGCGTCTCGGCAG
AAAGAATATTGCGAGTATTACTGAGGGTACATGAAGGAGAGAAGCCCCTTTGGTTCGGCCTTGGACTAAGCCCTTGTTCTCAGGTGAACT
TGCAGTGTGATCTTGAGTAAGGTCAGTCTCCTCTCTCACCTCAGTGGCCCGAAACCTCAGGAGGTGGCAGAGGTTTTCTAATGACTCTCC
CAGCTCTGACATCCTCTGACTTCACTCTGGGAGAACGTGGGCTGGTGGACTCCTGGCAGAAGCCGACACACAGTTGGGCCATAACAAAGA
GCCCTGGTACGGGGCACGTTCCCGCCCCCGGGAGGTTTTGGAAACACTGTGAGGCAGGGGGCGGGGCTTGAGCGGGCCGCAGCCAGTCAC
CAAAGGGCCGGGCGCTGGGGGCGGGGCCTCGCGCGAGCGGCGGCGGTAGCGGCGGCAGCGGCTGCGGCCAAGCTGGGTCCGAGCATCCCG
CGGCTCTGGAGCCGCCCGGCCCGGACATGGCGACCGTCCGGGCCTCTCTGCGAGGTGCGCTGCTCCTTCTGCTGGCCGTGGCGGGGGTCG
CGGAGGTGGCAGGGGGCCTGGCTCCGGGCAGTGCGGGTGCATTGTGTTGTAATCATTCAAAGGATAACCAAATGTGCCGTGATGTATGTG
AACAGATTTTCTCCTCAAAAAGTGAATCCCGACTAAAACATCTGTTGCAGCGAGCCCCAGATTATTGCCCAGAGACAATGGTTGAAATTT
GGAATTGTATGAATTCATCTTTGCCAGGTGTGTTTAAGAAGTCTGATGGCTGGGTTGGCTTAGGCTGCTGTGAACTGGCTATTGCCTTGG
AGTGTCGACAGGCATGCAAGCAGGCATCTTCAAAGAATGATATTTCCAAAGTTTGCAGAAAAGAATATGAGTGCACTTGCAGGAAAGACA
TGGTGAAGATTTCAATGGATATCTTTGTGAGGAAATTTCAGCCAGACAGATATCAGCTTTGGAAACAAGGAAAGGATATATACACCATTG
ATCACACGAAGCCTACTCCAGCATCCACCCCTGAAGTAAAAGCATGGCTGCAGAGGAGGAGGAAAGTAAGAAAAGCATCCCGAAGCTTCC
AGTGTGCTAGGTCTACCTCTAAAAGGCCTAAGGCTGATGAGGAAGAGGAAGTGTCAGATGAAGTCGATGGGGCAGAGGTCCCTAACCCCG
ACTCAGTCACAGATGACCTCAAGGTCAGTGAAAAGTCAGAAGCAGCAGTGAAGCTGAGGAACACAGAAGCATCTTCAGAAGAAGAGTCAT
CTGCTAGCAGGATGCAGGTGGAGCAGAATTTATCAGATCATATCAAACTCTCAGGAAACAGCTGCTTAAGTACATCTGTAACAGAAGACA
TAAAAACTGAGGATGACAAAGCTTATGCATATAGAAGTGTACCTTCTATATCCAGTGAGGCTGATGATTCCATTCCATTGTCTAGTGGCT
ATGAGAAGCCCGAGAAATCAGACCCATCCGAGCTTTCATGGCCAAAGTCACCTGAGTCATGCTCATCAGTGGCAGAGAGTAATGGTGTGT
TAACAGAGGGAGAAGAGAGTGATGTGGAGAGCCATGGGAATGGCCTTGAACCTGGGGAAATCCCAGCGGTCCCCAGTGGAGAGAGAAATA
GCTTCAAAGTCCCCAGTATAGCAGAGGGAGAGAACAAAACCTCTAAGAGTTGGCGCCATCCACTTAGCAGGCCTCCAGCAAGATCTCCGA
TGACTCTTGTGAAGCAGCAGGCGCCAAGTGATGAAGAATTGCCTGAGGTTCTGTCCATTGAGGAGGAAGTGGAAGAAACAGAGTCTTGGG
CGAAACCTCTCATCCACCTTTGGCAGACGAAGTCCCCTAACTTCGCAGCTGAGCAAGAGTATAATGCAACAGTGGCCAGGATGAAGCCAC
ACTGTGCCATCTGCACTCTGCTCATGCCGTACCACAAGCCAGATAGCAGCAATGAAGAAAATGATGCTAGATGGGAGACAAAATTAGATG
AAGTCGTTACATCGGAGGGAAAGACTAAGCCCCTCATACCAGAGATGTGTTTTATTTATAGTGAAGAAAATATAGAATATTCTCCACCCA
ATGCCTTCCTTGAAGAGGATGGAACAAGTCTCCTTATTTCCTGTGCAAAGTGCTGCGTACGGGTTCATGCAAGTTGTTATGGTATTCCTT
CTCATGAGATCTGTGATGGATGGCTGTGTGCCCGGTGCAAAAGAAATGCGTGGACAGCAGAATGCTGTCTCTGCAATTTGAGAGGAGGTG
CTCTTAAGCAAACGAAGAACAATAAGTGGGCCCATGTCATGTGCGCCGTTGCGGTCCCAGAAGTTCGATTCACTAATGTCCCAGAAAGGA
CACAAATAGATGTAGGCAGAATACCTTTACAGAGGTTAAAATTGAAATGCATCTTCTGCAGACACCGGGTTAAGAGGGTCTCTGGAGCCT
GCATCCAGTGTTCCTACGGTCGCTGCCCGGCCTCCTTCCATGTCACTTGTGCCCATGCTGCTGGGGTACTGATGGAGCCTGATGACTGGC
CTTATGTGGTGAACATTACATGCTTTCGACATAAGGTCAACCCCAACGTGAAGTCCAAGGCTTGCGAGAAGGTCATTTCCGTGGGTCAAA
CGGTCATCACGAAGCATCGGAACACCCGGTATTACAGTTGCAGAGTGATGGCTGTGACATCGCAGACCTTCTATGAGGTCATGTTTGATG
ATGGCTCCTTTAGCAGAGACACATTTCCTGAGGATATCGTGAGCCGAGACTGTCTGAAGCTGGGCCCACCTGCTGAGGGAGAAGTCGTCC
AAGTCAAGTGGCCCGATGGCAAACTCTATGGAGCAAAATATTTTGGATCAAATATTGCCCACATGTACCAGGTTGAGTTTGAAGATGGAT
CCCAGATAGCAATGAAGAGAGAGGACATCTACACTTTAGATGAAGAGTTACCCAAGAGAGTGAAAGCTCGATTTTCCACAGCCTCTGACA
TGCGATTTGAAGACACGTTTTATGGAGCAGACATTATCCAAGGGGAGAGAAAGAGACAAAGAGTGCTGAGCTCCAGGTTTAAGAATGAAT
ATGTGGCCGACCCTGTATACCGCACTTTTTTGAAGAGCTCTTTCCAGAAGAAGTGCCAGAAGAGACAGTAGTCTGCATACATCGCTGCAG
GCCACAGAGCAGCTTGGGTTGGAAGAGAGAAGATGAAGGGACATCCTTGGGGCTGTGCCGTGAGTTTTGCTGGCATAGGTGACAGGGTGT
GTCTCTGACAGTGGTAAATCGGGTTTCCAGAGTTTGGTCACCAAAAATACAAAATACACCCAATGAATTGGACGCAGCAATCTGAAATCA
TCTCTAGTCTTGCTTTCACTTGTGAGCAGTTGTCTTCTATGATCCCAAAGAAGTTTTCTAAGTGAAAGGAAATACTAGTGAATCACCCAC
AAGGAAAAGCCACTGCCACAGAGGAGGCGGGTCCCCTTGTGCGGCTTAGGGCCCTGTCAGGAAACACACGGGGACCTCTCTCTCTAGCTC
CAGCAGGTGGCACCTCGGTACCCAGCGGGTAGGGCGATAATTTATATATTTTCCACAGTCAGGGAAGGACTCTCACTTATTTGTTTCAAA
TTGCAGTTTTTATAAAACATTTTTAAAACACAAATGGCATGTATGCTAATGAGATTTACCCGTGTGCTATCTGTATTTCCCTTGTACAGA
ACTTTTACATTTTTGAATATTCCTATTACTTTTGATTGTGTCTGATGGGAACTGAGTTGTTGGCCTTTGTGAAATGAAATTTTTGGCTCT
TGAGAAAGAATTCTTATGAATTGTTATGCGAATTTTATATATTTAAAGAGGGAGATCTGGGGCTGTTATTTTTAAACACTTTTTTTCATA
ATACATATTCCGAGTAGATATTTATAAAATATATGTTTCTTTCATTATGTGTTTGTAAAATTAGAGTTTAAATAAATATGCTTTGATGCA
TAGTTTTGAACTAATGTAACATGATTTTTCTTTTTTAAAACAGCCTGAAAATGTACTAGTGTTTAAAAATAAAGATTTCCATTTTCTCCA

>73370_73370_2_RECK-KDM4C_RECK_chr9_36065621_ENST00000377966_KDM4C_chr9_6980924_ENST00000381309_length(amino acids)=918AA_BP=169
MGAGPRASGGGSGGSGCGQAGSEHPAALEPPGPDMATVRASLRGALLLLLAVAGVAEVAGGLAPGSAGALCCNHSKDNQMCRDVCEQIFS
SKSESRLKHLLQRAPDYCPETMVEIWNCMNSSLPGVFKKSDGWVGLGCCELAIALECRQACKQASSKNDISKVCRKEYECTCRKDMVKIS
MDIFVRKFQPDRYQLWKQGKDIYTIDHTKPTPASTPEVKAWLQRRRKVRKASRSFQCARSTSKRPKADEEEEVSDEVDGAEVPNPDSVTD
DLKVSEKSEAAVKLRNTEASSEEESSASRMQVEQNLSDHIKLSGNSCLSTSVTEDIKTEDDKAYAYRSVPSISSEADDSIPLSSGYEKPE
KSDPSELSWPKSPESCSSVAESNGVLTEGEESDVESHGNGLEPGEIPAVPSGERNSFKVPSIAEGENKTSKSWRHPLSRPPARSPMTLVK
QQAPSDEELPEVLSIEEEVEETESWAKPLIHLWQTKSPNFAAEQEYNATVARMKPHCAICTLLMPYHKPDSSNEENDARWETKLDEVVTS
EGKTKPLIPEMCFIYSEENIEYSPPNAFLEEDGTSLLISCAKCCVRVHASCYGIPSHEICDGWLCARCKRNAWTAECCLCNLRGGALKQT
KNNKWAHVMCAVAVPEVRFTNVPERTQIDVGRIPLQRLKLKCIFCRHRVKRVSGACIQCSYGRCPASFHVTCAHAAGVLMEPDDWPYVVN
ITCFRHKVNPNVKSKACEKVISVGQTVITKHRNTRYYSCRVMAVTSQTFYEVMFDDGSFSRDTFPEDIVSRDCLKLGPPAEGEVVQVKWP
DGKLYGAKYFGSNIAHMYQVEFEDGSQIAMKREDIYTLDEELPKRVKARFSTASDMRFEDTFYGADIIQGERKRQRVLSSRFKNEYVADP

--------------------------------------------------------------
>73370_73370_3_RECK-KDM4C_RECK_chr9_36065621_ENST00000377966_KDM4C_chr9_6980924_ENST00000442236_length(transcript)=3094nt_BP=971nt
GATGAACCCTTGTCAGGGGGCCGTGTCTGCGGGAGGCCGAAGGATCCCGGGTGACATGCTTTCTTTGGGTGCGAGGCAGCGTCTCGGCAG
AAAGAATATTGCGAGTATTACTGAGGGTACATGAAGGAGAGAAGCCCCTTTGGTTCGGCCTTGGACTAAGCCCTTGTTCTCAGGTGAACT
TGCAGTGTGATCTTGAGTAAGGTCAGTCTCCTCTCTCACCTCAGTGGCCCGAAACCTCAGGAGGTGGCAGAGGTTTTCTAATGACTCTCC
CAGCTCTGACATCCTCTGACTTCACTCTGGGAGAACGTGGGCTGGTGGACTCCTGGCAGAAGCCGACACACAGTTGGGCCATAACAAAGA
GCCCTGGTACGGGGCACGTTCCCGCCCCCGGGAGGTTTTGGAAACACTGTGAGGCAGGGGGCGGGGCTTGAGCGGGCCGCAGCCAGTCAC
CAAAGGGCCGGGCGCTGGGGGCGGGGCCTCGCGCGAGCGGCGGCGGTAGCGGCGGCAGCGGCTGCGGCCAAGCTGGGTCCGAGCATCCCG
CGGCTCTGGAGCCGCCCGGCCCGGACATGGCGACCGTCCGGGCCTCTCTGCGAGGTGCGCTGCTCCTTCTGCTGGCCGTGGCGGGGGTCG
CGGAGGTGGCAGGGGGCCTGGCTCCGGGCAGTGCGGGTGCATTGTGTTGTAATCATTCAAAGGATAACCAAATGTGCCGTGATGTATGTG
AACAGATTTTCTCCTCAAAAAGTGAATCCCGACTAAAACATCTGTTGCAGCGAGCCCCAGATTATTGCCCAGAGACAATGGTTGAAATTT
GGAATTGTATGAATTCATCTTTGCCAGGTGTGTTTAAGAAGTCTGATGGCTGGGTTGGCTTAGGCTGCTGTGAACTGGCTATTGCCTTGG
AGTGTCGACAGGCATGCAAGCAGGCATCTTCAAAGAATGATATTTCCAAAGTTTGCAGAAAAGAATATGAGTGCACTTGCAGGAAAGACA
TGGTGAAGATTTCAATGGATATCTTTGTGAGGAAATTTCAGCCAGACAGATATCAGCTTTGGAAACAAGGAAAGGATATATACACCATTG
ATCACACGAAGCCTACTCCAGCATCCACCCCTGAAGTAAAAGCATGGCTGCAGAGGAGGAGGAAAGTAAGAAAAGCATCCCGAAGCTTCC
AGTGTGCTAGGTCTACCTCTAAAAGGCCTAAGGCTGATGAGGAAGAGGAAGTGTCAGATGAAGTCGATGGGGCAGAGGTCCCTAACCCCG
ACTCAGTCACAGATGACCTCAAGGTCAGTGAAAAGTCAGAAGCAGCAGTGAAGCTGAGGAACACAGAAGCATCTTCAGAAGAAGAGTCAT
CTGCTAGCAGGATGCAGGTGGAGCAGAATTTATCAGATCATATCAAACTCTCAGGAAACAGCTGCTTAAGTACATCTGTAACAGAAGACA
TAAAAACTGAGGATGACAAAGCTTATGCATATAGAAGTGTACCTTCTATATCCAGTGAGGCTGATGATTCCATTCCATTGTCTAGTGGCT
ATGAGAAGCCCGAGAAATCAGACCCATCCGAGCTTTCATGGCCAAAGTCACCTGAGTCATGCTCATCAGTGGCAGAGAGTAATGAATTGC
CTGAGGTTCTGTCCATTGAGGAGGAAGTGGAAGAAACAGAGTCTTGGGCGAAACCTCTCATCCACCTTTGGCAGACGAAGTCCCCTAACT
TCGCAGCTGAGCAAGAGTATAATGCAACAGTGGCCAGGATGAAGCCACACTGTGCCATCTGCACTCTGCTCATGCCGTACCACAAGCCAG
ATAGCAGCAATGAAGAAAATGATGCTAGATGGGAGACAAAATTAGATGAAGTCGTTACATCGGAGGGAAAGACTAAGCCCCTCATACCAG
AGATGTGTTTTATTTATAGTGAAGAAAATATAGAATATTCTCCACCCAATGCCTTCCTTGAAGAGGATGGAACAAGTCTCCTTATTTCCT
GTGCAAAGTGCTGCGTACGGGTTCATGCAAGTTGTTATGGTATTCCTTCTCATGAGATCTGTGATGGATGGCTGTGTGCCCGGTGCAAAA
GAAATGCGTGGACAGCAGAATGCTGTCTCTGCAATTTGAGAGGAGGTGCTCTTAAGCAAACGAAGAACAATAAGTGGGCCCATGTCATGT
GCGCCGTTGCGGTCCCAGAAGTTCGATTCACTAATGTCCCAGAAAGGACACAAATAGATGTAGGCAGAATACCTTTACAGAGGTTAAAAT
TGAAATGCATCTTCTGCAGACACCGGGTTAAGAGGGTCTCTGGAGCCTGCATCCAGTGTTCCTACGGTCGCTGCCCGGCCTCCTTCCATG
TCACTTGTGCCCATGCTGCTGGGGTACTGATGGAGCCTGATGACTGGCCTTATGTGGTGAACATTACATGCTTTCGACATAAGGTCAACC
CCAACGTGAAGTCCAAGGCTTGCGAGAAGGTCATTTCCGTGGGTCAAACGGTCATCACGAAGCATCGGAACACCCGGTATTACAGTTGCA
GAGTGATGGCTGTGACATCGCAGACCTTCTATGAGGTCATGTTTGATGATGGCTCCTTTAGCAGAGACACATTTCCTGAGGATATCGTGA
GCCGAGACTGTCTGAAGCTGGGCCCACCTGCTGAGGGAGAAGTCGTCCAAGTCAAGTGGCCCGATGGCAAACTCTATGGAGCAAAATATT
TTGGATCAAATATTGCCCACATGTACCAGGTTGAGTTTGAAGATGGATCCCAGATAGCAATGAAGAGAGAGGACATCTACACTTTAGATG
AAGAGTTACCCAAGAGAGTGAAAGCTCGATTTTCCACAGCCTCTGACATGCGATTTGAAGACACGTTTTATGGAGCAGACATTATCCAAG
GGGAGAGAAAGAGACAAAGAGTGCTGAGCTCCAGGTTTAAGAATGAATATGTGGCCGACCCTGTATACCGCACTTTTTTGAAGAGCTCTT
TCCAGAAGAAGTGCCAGAAGAGACAGTAGTCTGCATACATCGCTGCAGGCCACAGAGCAGCTTGGGTTGGAAGAGAGAAGATGAAGGGAC

>73370_73370_3_RECK-KDM4C_RECK_chr9_36065621_ENST00000377966_KDM4C_chr9_6980924_ENST00000442236_length(amino acids)=844AA_BP=169
MGAGPRASGGGSGGSGCGQAGSEHPAALEPPGPDMATVRASLRGALLLLLAVAGVAEVAGGLAPGSAGALCCNHSKDNQMCRDVCEQIFS
SKSESRLKHLLQRAPDYCPETMVEIWNCMNSSLPGVFKKSDGWVGLGCCELAIALECRQACKQASSKNDISKVCRKEYECTCRKDMVKIS
MDIFVRKFQPDRYQLWKQGKDIYTIDHTKPTPASTPEVKAWLQRRRKVRKASRSFQCARSTSKRPKADEEEEVSDEVDGAEVPNPDSVTD
DLKVSEKSEAAVKLRNTEASSEEESSASRMQVEQNLSDHIKLSGNSCLSTSVTEDIKTEDDKAYAYRSVPSISSEADDSIPLSSGYEKPE
KSDPSELSWPKSPESCSSVAESNELPEVLSIEEEVEETESWAKPLIHLWQTKSPNFAAEQEYNATVARMKPHCAICTLLMPYHKPDSSNE
ENDARWETKLDEVVTSEGKTKPLIPEMCFIYSEENIEYSPPNAFLEEDGTSLLISCAKCCVRVHASCYGIPSHEICDGWLCARCKRNAWT
AECCLCNLRGGALKQTKNNKWAHVMCAVAVPEVRFTNVPERTQIDVGRIPLQRLKLKCIFCRHRVKRVSGACIQCSYGRCPASFHVTCAH
AAGVLMEPDDWPYVVNITCFRHKVNPNVKSKACEKVISVGQTVITKHRNTRYYSCRVMAVTSQTFYEVMFDDGSFSRDTFPEDIVSRDCL
KLGPPAEGEVVQVKWPDGKLYGAKYFGSNIAHMYQVEFEDGSQIAMKREDIYTLDEELPKRVKARFSTASDMRFEDTFYGADIIQGERKR

--------------------------------------------------------------
>73370_73370_4_RECK-KDM4C_RECK_chr9_36065621_ENST00000377966_KDM4C_chr9_6980924_ENST00000535193_length(transcript)=3303nt_BP=971nt
GATGAACCCTTGTCAGGGGGCCGTGTCTGCGGGAGGCCGAAGGATCCCGGGTGACATGCTTTCTTTGGGTGCGAGGCAGCGTCTCGGCAG
AAAGAATATTGCGAGTATTACTGAGGGTACATGAAGGAGAGAAGCCCCTTTGGTTCGGCCTTGGACTAAGCCCTTGTTCTCAGGTGAACT
TGCAGTGTGATCTTGAGTAAGGTCAGTCTCCTCTCTCACCTCAGTGGCCCGAAACCTCAGGAGGTGGCAGAGGTTTTCTAATGACTCTCC
CAGCTCTGACATCCTCTGACTTCACTCTGGGAGAACGTGGGCTGGTGGACTCCTGGCAGAAGCCGACACACAGTTGGGCCATAACAAAGA
GCCCTGGTACGGGGCACGTTCCCGCCCCCGGGAGGTTTTGGAAACACTGTGAGGCAGGGGGCGGGGCTTGAGCGGGCCGCAGCCAGTCAC
CAAAGGGCCGGGCGCTGGGGGCGGGGCCTCGCGCGAGCGGCGGCGGTAGCGGCGGCAGCGGCTGCGGCCAAGCTGGGTCCGAGCATCCCG
CGGCTCTGGAGCCGCCCGGCCCGGACATGGCGACCGTCCGGGCCTCTCTGCGAGGTGCGCTGCTCCTTCTGCTGGCCGTGGCGGGGGTCG
CGGAGGTGGCAGGGGGCCTGGCTCCGGGCAGTGCGGGTGCATTGTGTTGTAATCATTCAAAGGATAACCAAATGTGCCGTGATGTATGTG
AACAGATTTTCTCCTCAAAAAGTGAATCCCGACTAAAACATCTGTTGCAGCGAGCCCCAGATTATTGCCCAGAGACAATGGTTGAAATTT
GGAATTGTATGAATTCATCTTTGCCAGGTGTGTTTAAGAAGTCTGATGGCTGGGTTGGCTTAGGCTGCTGTGAACTGGCTATTGCCTTGG
AGTGTCGACAGGCATGCAAGCAGGCATCTTCAAAGAATGATATTTCCAAAGTTTGCAGAAAAGAATATGAGTGCACTTGCAGGAAAGACA
TGGTGAAGATTTCAATGGATATCTTTGTGAGGAAATTTCAGCCAGACAGATATCAGCTTTGGAAACAAGGAAAGGATATATACACCATTG
ATCACACGAAGCCTACTCCAGCATCCACCCCTGAAGTAAAAGCATGGCTGCAGAGGAGGAGGAAAGTAAGAAAAGCATCCCGAAGCTTCC
AGTGTGCTAGGTCTACCTCTAAAAGGCCTAAGGCTGATGAGGAAGAGGAAGTGTCAGATGAAGTCGATGGGGCAGAGGTCCCTAACCCCG
ACTCAGTCACAGATGACCTCAAGGTCAGTGAAAAGTCAGAAGCAGCAGTGAAGCTGAGGAACACAGAAGCATCTTCAGAAGAAGAGTCAT
CTGCTAGCAGGATGCAGGTGGAGCAGAATTTATCAGATCATATCAAACTCTCAGGAAACAGCTGCTTAAGTACATCTGTAACAGAAGACA
TAAAAACTGAGGATGACAAAGCTTATGCATATAGAAGTGTACCTTCTATATCCAGTGAGGCTGATGATTCCATTCCATTGTCTAGTGGCT
ATGAGAAGCCCGAGAAATCAGACCCATCCGAGCTTTCATGGCCAAAGTCACCTGAGTCATGCTCATCAGTGGCAGAGAGTAATGGTGTGT
TAACAGAGGGAGAAGAGAGTGATGTGGAGAGCCATGGGAATGGCCTTGAACCTGGGGAAATCCCAGCGGTCCCCAGTGGAGAGAGAAATA
GCTTCAAAGTCCCCAGTATAGCAGAGGGAGAGAACAAAACCTCTAAGAGTTGGCGCCATCCACTTAGCAGGCCTCCAGCAAGATCTCCGA
TGACTCTTGTGAAGCAGCAGGCGCCAAGTGATGAAGAATTGCCTGAGGTTCTGTCCATTGAGGAGGAAGTGGAAGAAACAGAGTCTTGGG
CGAAACCTCTCATCCACCTTTGGCAGACGAAGTCCCCTAACTTCGCAGCTGAGCAAGAGTATAATGCAACAGTGGCCAGGATGAAGCCAC
ACTGTGCCATCTGCACTCTGCTCATGCCGTACCACAAGCCAGATAGCAGCAATGAAGAAAATGATGCTAGATGGGAGACAAAATTAGATG
AAGTCGTTACATCGGAGGGAAAGACTAAGCCCCTCATACCAGAGATGTGTTTTATTTATAGTGAAGAAAATATAGAATATTCTCCACCCA
ATGCCTTCCTTGAAGAGGATGGAACAAGTCTCCTTATTTCCTGTGCAAAGTGCTGCGTACGGGTTCATGCAAGTTGTTATGGTATTCCTT
CTCATGAGATCTGTGATGGATGGCTGTGTGCCCGGTGCAAAAGAAATGCGTGGACAGCAGAATGCTGTCTCTGCAATTTGAGAGGAGGTG
CTCTTAAGCAAACGAAGAACAATAAGTGGGCCCATGTCATGTGCGCCGTTGCGGTCCCAGAAGTTCGATTCACTAATGTCCCAGAAAGGA
CACAAATAGATGTAGGCAGAATACCTTTACAGAGGTTAAAATTGGGAAGGCTGGGAATCTAGACACAGCAACAGTAACAACAACAACAAT
AACAATGAAGGCTCACTGTGAAAACATCAATTCATTAGGAAAGTTACATCCCCTCCGCCACTGTTTCAGATGCTGTTTCTCATTCTCCAT
GGGAGCAGCCAGCATCGTGTTTAGGATGGGGATACAATAGCCTGAGCTCCTGATTGAGTCAGACCCTGGACTTTCCCTTTTGTATCTGTC
ATTTTCCTCTGGATCCTCACACCTTTGTGTTTAATTTTTTTAAATTTCATTTGTTGACTTCCTATGTGGGGTAAAATGACTTCCTTTGAT
TAATGTACTTTCTGTATCCTAGAGTTTCCCTTTCCCTTTGTGATTTAGTCCAACGTGTCCTACTACAGCCTCAAAAATTGTCATTGGAAT
CAAAAGCTTTCCAAGGTGCATCAGGTTAATGATTTGGATGCATCCTGAGGTTGTCTCCTGTAGCATGGAGGCATTATAATAGGAGTCTCA
GAAGTTACACCATTTTTCTACAGCACATCACAGGCCCAGAGGCTTGAATCTAAGAGAATCCACTCTATGTCTGTCAGCCTGAATCCTTCC
TTCTTGCTGCACAACAAAGCAACTGAACGTATTTTGAGTTTAGGTGAAAACTATCACTCATTCATCAAAGTTCTATCTGGGTGATATATG
CTATCGAAACAGATGTGGACACTGGGCTGACAGATGTTGAGAACGGACCTGTTGCTGAAGCTCATGTTATCACACATGCTGTGGGAAGAG

>73370_73370_4_RECK-KDM4C_RECK_chr9_36065621_ENST00000377966_KDM4C_chr9_6980924_ENST00000535193_length(amino acids)=675AA_BP=169
MGAGPRASGGGSGGSGCGQAGSEHPAALEPPGPDMATVRASLRGALLLLLAVAGVAEVAGGLAPGSAGALCCNHSKDNQMCRDVCEQIFS
SKSESRLKHLLQRAPDYCPETMVEIWNCMNSSLPGVFKKSDGWVGLGCCELAIALECRQACKQASSKNDISKVCRKEYECTCRKDMVKIS
MDIFVRKFQPDRYQLWKQGKDIYTIDHTKPTPASTPEVKAWLQRRRKVRKASRSFQCARSTSKRPKADEEEEVSDEVDGAEVPNPDSVTD
DLKVSEKSEAAVKLRNTEASSEEESSASRMQVEQNLSDHIKLSGNSCLSTSVTEDIKTEDDKAYAYRSVPSISSEADDSIPLSSGYEKPE
KSDPSELSWPKSPESCSSVAESNGVLTEGEESDVESHGNGLEPGEIPAVPSGERNSFKVPSIAEGENKTSKSWRHPLSRPPARSPMTLVK
QQAPSDEELPEVLSIEEEVEETESWAKPLIHLWQTKSPNFAAEQEYNATVARMKPHCAICTLLMPYHKPDSSNEENDARWETKLDEVVTS
EGKTKPLIPEMCFIYSEENIEYSPPNAFLEEDGTSLLISCAKCCVRVHASCYGIPSHEICDGWLCARCKRNAWTAECCLCNLRGGALKQT

--------------------------------------------------------------
>73370_73370_5_RECK-KDM4C_RECK_chr9_36065621_ENST00000377966_KDM4C_chr9_6980924_ENST00000543771_length(transcript)=3303nt_BP=971nt
GATGAACCCTTGTCAGGGGGCCGTGTCTGCGGGAGGCCGAAGGATCCCGGGTGACATGCTTTCTTTGGGTGCGAGGCAGCGTCTCGGCAG
AAAGAATATTGCGAGTATTACTGAGGGTACATGAAGGAGAGAAGCCCCTTTGGTTCGGCCTTGGACTAAGCCCTTGTTCTCAGGTGAACT
TGCAGTGTGATCTTGAGTAAGGTCAGTCTCCTCTCTCACCTCAGTGGCCCGAAACCTCAGGAGGTGGCAGAGGTTTTCTAATGACTCTCC
CAGCTCTGACATCCTCTGACTTCACTCTGGGAGAACGTGGGCTGGTGGACTCCTGGCAGAAGCCGACACACAGTTGGGCCATAACAAAGA
GCCCTGGTACGGGGCACGTTCCCGCCCCCGGGAGGTTTTGGAAACACTGTGAGGCAGGGGGCGGGGCTTGAGCGGGCCGCAGCCAGTCAC
CAAAGGGCCGGGCGCTGGGGGCGGGGCCTCGCGCGAGCGGCGGCGGTAGCGGCGGCAGCGGCTGCGGCCAAGCTGGGTCCGAGCATCCCG
CGGCTCTGGAGCCGCCCGGCCCGGACATGGCGACCGTCCGGGCCTCTCTGCGAGGTGCGCTGCTCCTTCTGCTGGCCGTGGCGGGGGTCG
CGGAGGTGGCAGGGGGCCTGGCTCCGGGCAGTGCGGGTGCATTGTGTTGTAATCATTCAAAGGATAACCAAATGTGCCGTGATGTATGTG
AACAGATTTTCTCCTCAAAAAGTGAATCCCGACTAAAACATCTGTTGCAGCGAGCCCCAGATTATTGCCCAGAGACAATGGTTGAAATTT
GGAATTGTATGAATTCATCTTTGCCAGGTGTGTTTAAGAAGTCTGATGGCTGGGTTGGCTTAGGCTGCTGTGAACTGGCTATTGCCTTGG
AGTGTCGACAGGCATGCAAGCAGGCATCTTCAAAGAATGATATTTCCAAAGTTTGCAGAAAAGAATATGAGTGCACTTGCAGGAAAGACA
TGGTGAAGATTTCAATGGATATCTTTGTGAGGAAATTTCAGCCAGACAGATATCAGCTTTGGAAACAAGGAAAGGATATATACACCATTG
ATCACACGAAGCCTACTCCAGCATCCACCCCTGAAGTAAAAGCATGGCTGCAGAGGAGGAGGAAAGTAAGAAAAGCATCCCGAAGCTTCC
AGTGTGCTAGGTCTACCTCTAAAAGGCCTAAGGCTGATGAGGAAGAGGAAGTGTCAGATGAAGTCGATGGGGCAGAGGTCCCTAACCCCG
ACTCAGTCACAGATGACCTCAAGGTCAGTGAAAAGTCAGAAGCAGCAGTGAAGCTGAGGAACACAGAAGCATCTTCAGAAGAAGAGTCAT
CTGCTAGCAGGATGCAGGTGGAGCAGAATTTATCAGATCATATCAAACTCTCAGGAAACAGCTGCTTAAGTACATCTGTAACAGAAGACA
TAAAAACTGAGGATGACAAAGCTTATGCATATAGAAGTGTACCTTCTATATCCAGTGAGGCTGATGATTCCATTCCATTGTCTAGTGGCT
ATGAGAAGCCCGAGAAATCAGACCCATCCGAGCTTTCATGGCCAAAGTCACCTGAGTCATGCTCATCAGTGGCAGAGAGTAATGGTGTGT
TAACAGAGGGAGAAGAGAGTGATGTGGAGAGCCATGGGAATGGCCTTGAACCTGGGGAAATCCCAGCGGTCCCCAGTGGAGAGAGAAATA
GCTTCAAAGTCCCCAGTATAGCAGAGGGAGAGAACAAAACCTCTAAGAGTTGGCGCCATCCACTTAGCAGGCCTCCAGCAAGATCTCCGA
TGACTCTTGTGAAGCAGCAGGCGCCAAGTGATGAAGAATTGCCTGAGGTTCTGTCCATTGAGGAGGAAGTGGAAGAAACAGAGTCTTGGG
CGAAACCTCTCATCCACCTTTGGCAGACGAAGTCCCCTAACTTCGCAGCTGAGCAAGAGTATAATGCAACAGTGGCCAGGATGAAGCCAC
ACTGTGCCATCTGCACTCTGCTCATGCCGTACCACAAGCCAGATAGCAGCAATGAAGAAAATGATGCTAGATGGGAGACAAAATTAGATG
AAGTCGTTACATCGGAGGGAAAGACTAAGCCCCTCATACCAGAGATGTGTTTTATTTATAGTGAAGAAAATATAGAATATTCTCCACCCA
ATGCCTTCCTTGAAGAGGATGGAACAAGTCTCCTTATTTCCTGTGCAAAGTGCTGCGTACGGGTTCATGCAAGTTGTTATGGTATTCCTT
CTCATGAGATCTGTGATGGATGGCTGTGTGCCCGGTGCAAAAGAAATGCGTGGACAGCAGAATGCTGTCTCTGCAATTTGAGAGGAGGTG
CTCTTAAGCAAACGAAGAACAATAAGTGGGCCCATGTCATGTGCGCCGTTGCGGTCCCAGAAGTTCGATTCACTAATGTCCCAGAAAGGA
CACAAATAGATGTAGGCAGAATACCTTTACAGAGGTTAAAATTGGGAAGGCTGGGAATCTAGACACAGCAACAGTAACAACAACAACAAT
AACAATGAAGGCTCACTGTGAAAACATCAATTCATTAGGAAAGTTACATCCCCTCCGCCACTGTTTCAGATGCTGTTTCTCATTCTCCAT
GGGAGCAGCCAGCATCGTGTTTAGGATGGGGATACAATAGCCTGAGCTCCTGATTGAGTCAGACCCTGGACTTTCCCTTTTGTATCTGTC
ATTTTCCTCTGGATCCTCACACCTTTGTGTTTAATTTTTTTAAATTTCATTTGTTGACTTCCTATGTGGGGTAAAATGACTTCCTTTGAT
TAATGTACTTTCTGTATCCTAGAGTTTCCCTTTCCCTTTGTGATTTAGTCCAACGTGTCCTACTACAGCCTCAAAAATTGTCATTGGAAT
CAAAAGCTTTCCAAGGTGCATCAGGTTAATGATTTGGATGCATCCTGAGGTTGTCTCCTGTAGCATGGAGGCATTATAATAGGAGTCTCA
GAAGTTACACCATTTTTCTACAGCACATCACAGGCCCAGAGGCTTGAATCTAAGAGAATCCACTCTATGTCTGTCAGCCTGAATCCTTCC
TTCTTGCTGCACAACAAAGCAACTGAACGTATTTTGAGTTTAGGTGAAAACTATCACTCATTCATCAAAGTTCTATCTGGGTGATATATG
CTATCGAAACAGATGTGGACACTGGGCTGACAGATGTTGAGAACGGACCTGTTGCTGAAGCTCATGTTATCACACATGCTGTGGGAAGAG

>73370_73370_5_RECK-KDM4C_RECK_chr9_36065621_ENST00000377966_KDM4C_chr9_6980924_ENST00000543771_length(amino acids)=675AA_BP=169
MGAGPRASGGGSGGSGCGQAGSEHPAALEPPGPDMATVRASLRGALLLLLAVAGVAEVAGGLAPGSAGALCCNHSKDNQMCRDVCEQIFS
SKSESRLKHLLQRAPDYCPETMVEIWNCMNSSLPGVFKKSDGWVGLGCCELAIALECRQACKQASSKNDISKVCRKEYECTCRKDMVKIS
MDIFVRKFQPDRYQLWKQGKDIYTIDHTKPTPASTPEVKAWLQRRRKVRKASRSFQCARSTSKRPKADEEEEVSDEVDGAEVPNPDSVTD
DLKVSEKSEAAVKLRNTEASSEEESSASRMQVEQNLSDHIKLSGNSCLSTSVTEDIKTEDDKAYAYRSVPSISSEADDSIPLSSGYEKPE
KSDPSELSWPKSPESCSSVAESNGVLTEGEESDVESHGNGLEPGEIPAVPSGERNSFKVPSIAEGENKTSKSWRHPLSRPPARSPMTLVK
QQAPSDEELPEVLSIEEEVEETESWAKPLIHLWQTKSPNFAAEQEYNATVARMKPHCAICTLLMPYHKPDSSNEENDARWETKLDEVVTS
EGKTKPLIPEMCFIYSEENIEYSPPNAFLEEDGTSLLISCAKCCVRVHASCYGIPSHEICDGWLCARCKRNAWTAECCLCNLRGGALKQT

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Fusion Gene PPI Analysis for RECK-KDM4C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RECK-KDM4C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RECK-KDM4C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource