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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ATAD2B-ITSN2 (FusionGDB2 ID:7338)

Fusion Gene Summary for ATAD2B-ITSN2

Fusion gene summary

Fusion gene information	Fusion gene name: ATAD2B-ITSN2
	Fusion gene ID: 7338
		Hgene	Tgene
	Gene symbol	ATAD2B	ITSN2
	Gene ID	54454	50618
	Gene name	ATPase family AAA domain containing 2B	intersectin 2
	Synonyms	-	PRO2015\|SH3D1B\|SH3P18\|SWA\|SWAP
	Cytomap	2p24.1-p23.3	2p23.3
	Type of gene	protein-coding	protein-coding
	Description	ATPase family AAA domain-containing protein 2B	intersectin-2SH3 domain-containing protein 1BSH3P18-like WASP-associated protein
	Modification date	20200313	20200313
	UniProtAcc	Q9ULI0	Q9NZM3
	Ensembl transtripts involved in fusion gene	ENST00000238789, ENST00000474583,	ENST00000406921, ENST00000407704, ENST00000355123, ENST00000361999,
Fusion gene scores	* DoF score	7 X 7 X 4=196	9 X 15 X 5=675
	# samples	7	15
	** MAII score	log2(7/196*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(15/675*10)=-2.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ATAD2B [Title/Abstract] AND ITSN2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ATAD2B(24021008)-ITSN2(24426652), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	ITSN2	GO:1903861	positive regulation of dendrite extension	23999003

Fusion gene breakpoints across ATAD2B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ITSN2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-LL-A740-01A	ATAD2B	chr2	24021008	-	ITSN2	chr2	24426652	-

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Fusion Gene ORF analysis for ATAD2B-ITSN2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000238789	ENST00000406921	ATAD2B	chr2	24021008	-	ITSN2	chr2	24426652	-
5CDS-intron	ENST00000238789	ENST00000407704	ATAD2B	chr2	24021008	-	ITSN2	chr2	24426652	-
5UTR-3CDS	ENST00000474583	ENST00000355123	ATAD2B	chr2	24021008	-	ITSN2	chr2	24426652	-
5UTR-3CDS	ENST00000474583	ENST00000361999	ATAD2B	chr2	24021008	-	ITSN2	chr2	24426652	-
5UTR-intron	ENST00000474583	ENST00000406921	ATAD2B	chr2	24021008	-	ITSN2	chr2	24426652	-
5UTR-intron	ENST00000474583	ENST00000407704	ATAD2B	chr2	24021008	-	ITSN2	chr2	24426652	-
In-frame	ENST00000238789	ENST00000355123	ATAD2B	chr2	24021008	-	ITSN2	chr2	24426652	-
In-frame	ENST00000238789	ENST00000361999	ATAD2B	chr2	24021008	-	ITSN2	chr2	24426652	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000238789	ATAD2B	chr2	24021008	-	ENST00000361999	ITSN2	chr2	24426652	-	3904	2984	272	3052	926
ENST00000238789	ATAD2B	chr2	24021008	-	ENST00000355123	ITSN2	chr2	24426652	-	3904	2984	272	3052	926

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000238789	ENST00000361999	ATAD2B	chr2	24021008	-	ITSN2	chr2	24426652	-	0.002021466	0.9979785
ENST00000238789	ENST00000355123	ATAD2B	chr2	24021008	-	ITSN2	chr2	24426652	-	0.002021466	0.9979785

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Fusion Genomic Features for ATAD2B-ITSN2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ATAD2B-ITSN2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:24021008/chr2:24426652)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ATAD2B Q9ULI0	ITSN2 Q9NZM3
	FUNCTION: Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000269\|PubMed:19458185, ECO:0000269\|PubMed:22648170, ECO:0000269\|PubMed:23999003}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ATAD2B

chr2:24021008

chr2:24426652

ENST00000238789

257_262

880

1459.0

Compositional bias

Note=Poly-Glu

Hgene

ATAD2B

chr2:24021008

chr2:24426652

ENST00000238789

441_448

880

1459.0

Nucleotide binding

ATP

Tgene

ITSN2

chr2:24021008

chr2:24426652

ENST00000406921

67_79

1250.0

Calcium binding

Ontology_term=ECO:0000255

Tgene

ITSN2

chr2:24021008

chr2:24426652

ENST00000406921

361_756

1250.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

ITSN2

chr2:24021008

chr2:24426652

ENST00000406921

1053_1117

1250.0

Domain

SH3 4

Tgene

ITSN2

chr2:24021008

chr2:24426652

ENST00000406921

1127_1186

1250.0

Domain

SH3 5

Tgene

ITSN2

chr2:24021008

chr2:24426652

ENST00000406921

1209_1395

1250.0

Domain

Tgene

ITSN2

chr2:24021008

chr2:24426652

ENST00000406921

1434_1544

1250.0

Domain

Tgene

ITSN2

chr2:24021008

chr2:24426652

ENST00000406921

1552_1668

1250.0

Domain

Tgene

ITSN2

chr2:24021008

chr2:24426652

ENST00000406921

22_110

1250.0

Domain

EH 1

Tgene

ITSN2

chr2:24021008

chr2:24426652

ENST00000406921

244_333

1250.0

Domain

EH 2

Tgene

ITSN2

chr2:24021008

chr2:24426652

ENST00000406921

54_89

1250.0

Domain

EF-hand

Tgene

ITSN2

chr2:24021008

chr2:24426652

ENST00000406921

757_818

1250.0

Domain

SH3 1

Tgene

ITSN2

chr2:24021008

chr2:24426652

ENST00000406921

898_956

1250.0

Domain

SH3 2

Tgene

ITSN2

chr2:24021008

chr2:24426652

ENST00000406921

981_1039

1250.0

Domain

SH3 3

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ATAD2B

chr2:24021008

chr2:24426652

ENST00000238789

943_974

880

1459.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ATAD2B

chr2:24021008

chr2:24426652

ENST00000238789

1247_1250

880

1459.0

Compositional bias

Note=Poly-Ser

Hgene

ATAD2B

chr2:24021008

chr2:24426652

ENST00000238789

975_1045

880

1459.0

Domain

Bromo

Tgene

ITSN2

chr2:24021008

chr2:24426652

ENST00000355123

67_79

1645

1698.0

Calcium binding

Ontology_term=ECO:0000255

Tgene

ITSN2

chr2:24021008

chr2:24426652

ENST00000361999

67_79

1618

1671.0

Calcium binding

Ontology_term=ECO:0000255

Tgene

ITSN2

chr2:24021008

chr2:24426652

ENST00000355123

361_756

1645

1698.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

ITSN2

chr2:24021008

chr2:24426652

ENST00000361999

361_756

1618

1671.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

ITSN2

chr2:24021008

chr2:24426652

ENST00000355123

1053_1117

1645

1698.0

Domain

SH3 4

Tgene

ITSN2

chr2:24021008

chr2:24426652

ENST00000355123

1127_1186

1645

1698.0

Domain

SH3 5

Tgene

ITSN2

chr2:24021008

chr2:24426652

ENST00000355123

1209_1395

1645

1698.0

Domain

Tgene

ITSN2

chr2:24021008

chr2:24426652

ENST00000355123

1434_1544

1645

1698.0

Domain

Tgene

ITSN2

chr2:24021008

chr2:24426652

ENST00000355123

1552_1668

1645

1698.0

Domain

Tgene

ITSN2

chr2:24021008

chr2:24426652

ENST00000355123

22_110

1645

1698.0

Domain

EH 1

Tgene

ITSN2

chr2:24021008

chr2:24426652

ENST00000355123

244_333

1645

1698.0

Domain

EH 2

Tgene

ITSN2

chr2:24021008

chr2:24426652

ENST00000355123

54_89

1645

1698.0

Domain

EF-hand

Tgene

ITSN2

chr2:24021008

chr2:24426652

ENST00000355123

757_818

1645

1698.0

Domain

SH3 1

Tgene

ITSN2

chr2:24021008

chr2:24426652

ENST00000355123

898_956

1645

1698.0

Domain

SH3 2

Tgene

ITSN2

chr2:24021008

chr2:24426652

ENST00000355123

981_1039

1645

1698.0

Domain

SH3 3

Tgene

ITSN2

chr2:24021008

chr2:24426652

ENST00000361999

1053_1117

1618

1671.0

Domain

SH3 4

Tgene

ITSN2

chr2:24021008

chr2:24426652

ENST00000361999

1127_1186

1618

1671.0

Domain

SH3 5

Tgene

ITSN2

chr2:24021008

chr2:24426652

ENST00000361999

1209_1395

1618

1671.0

Domain

Tgene

ITSN2

chr2:24021008

chr2:24426652

ENST00000361999

1434_1544

1618

1671.0

Domain

Tgene

ITSN2

chr2:24021008

chr2:24426652

ENST00000361999

1552_1668

1618

1671.0

Domain

Tgene

ITSN2

chr2:24021008

chr2:24426652

ENST00000361999

22_110

1618

1671.0

Domain

EH 1

Tgene

ITSN2

chr2:24021008

chr2:24426652

ENST00000361999

244_333

1618

1671.0

Domain

EH 2

Tgene

ITSN2

chr2:24021008

chr2:24426652

ENST00000361999

54_89

1618

1671.0

Domain

EF-hand

Tgene

ITSN2

chr2:24021008

chr2:24426652

ENST00000361999

757_818

1618

1671.0

Domain

SH3 1

Tgene

ITSN2

chr2:24021008

chr2:24426652

ENST00000361999

898_956

1618

1671.0

Domain

SH3 2

Tgene

ITSN2

chr2:24021008

chr2:24426652

ENST00000361999

981_1039

1618

1671.0

Domain

SH3 3

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Fusion Gene Sequence for ATAD2B-ITSN2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>7338_7338_1_ATAD2B-ITSN2_ATAD2B_chr2_24021008_ENST00000238789_ITSN2_chr2_24426652_ENST00000355123_length(transcript)=3904nt_BP=2984nt
CCTGCGGCGCTGGAGCCTTGACGCACGGAGCTCGAGAGCGAGAACGGGAGAGAAAGGGGTAGAAATGGCGGCTCCGCTCGGCTCCCGCTG
AGGAGGGCGAAGCCGGCGGAGTGTCTGTGCTGCCGGTCTGCAGCACCGCCCCCGCTTCCCGCACGCCGCCTGCTCACGCCGACTTCCCTT
CCTCTGCCCGGCTCTCTCTTGTGCTCGTCTGCGCTCCGCACGCTCCGGGCCGGCTCGTCTCTCATTGCCCGGCTCGGCTCCGCTGGCCCT
GACTGACCGGCCGGCGGGCCGGCCTTGCTCGGCTCTCCCGGGCGCGGCGTGGACTCCGTCCCCCTGGCTGGACCATGGTGAACACCCGGA
AGAGCTCTCTCCGCCTTCTCGGGTCCAAGTCTCCTGGTCCCGGGCCTGGGCCTGGGGCCGGAGCAGAGCCTGGGGCGACCGGAGGCAGCA
GCCATTTCATCTCCTCTCGGACCCGCTCCTCCAAGACCCGCGCCGCCAGCTGCCCCGCCGCCAAAGCCGGGGGAAGCGGTGGCGCCGGCG
TCACTCTGGATGAGGCCAGGAAAGTTGAAGTTGATGGTAGTTTAAGTGATAGCCACGTATCTCCTCCAGCCAAACGCACTTTGAAACAAC
CTGATTCTGTTTGCAAAGACAAATCAAAATCACGAAGTACTGGTCAGCGAGAGGAATGGAACTTATCAACTGGACAGGCCAGGTTAACTT
CTCAGCCTGGTGCTACATTACCAAATGGACATAGTGGCTTATCCCTTCGAAGCCATCCCCTTCGAGGGGAAAAGAAGGGAGATGGGGACC
TTTCTTGTATAAATGGTGACATGGAAGTCAGAAAAAGTTGTCGTTCCAGGAAAAACAGATTTGAAAGTGTGAACCAGAGTTTGTTATTTG
ATCAACTAGTAAATAGCACTGCTGAAGCTGTACTACAGGAAATGGACAACATTAACATCCGACAGAATCGTCGATCAGGAGAAGTAGAAC
GACTTCGAATGTGGACAGATACAGAATTTGAAAACATGGATATGTATTCAAGAGTGAAAAGGCGAAGAAAGTCACTAAGAAGAAATAGTT
ATGGGATACAAAATCATCATGAAGTTTCTACTGAGGGTGAAGAAGAAGAATCTCAAGAGGAGGATGGAGATATAGAAGTTGAAGAGGCAG
AAGGAGAAGAAAATGATAGACCATATAATTTGAGACAGAGAAAAACAGTGGATCGATACCAAGCACCTCCAATAGTACCAGCTCATCAAA
AAAAGAGGGAAAACACGCTGTTTGATATTCATAGATCTCCAGCAAGAAGAAGCCATATTAGGAGAAAGAAGCATGCCATTCATAGTAGTG
ACACAACTTCTTCTGATGAGGAACGCTTTGAAAGAAGGAAATCAAAGAGCATGGCAAGAGCAAGAAATAGATGTTTGCCTATGAACTTCA
GAGCAGAGGACTTAGCTAGCGGTATTCTCCGAGAACGAGTGAAAGTGGGTGCAAGCTTGGCTGATGTTGATCCAATGAACATTGATAAAT
CAGTACGGTTTGATAGCATAGGTGGATTGAGCCATCATATTCATGCGCTAAAGGAAATGGTAGTATTCCCACTTTTATATCCAGAAATTT
TTGAAAAGTTTAAAATTCAGCCTCCAAGGGGCTGTTTGTTTTATGGCCCTCCTGGCACAGGTAAAACCTTGGTTGCCAGAGCATTAGCTA
ATGAATGCAGCCAAGGAGACAAAAAAGTGGCTTTTTTTATGCGAAAAGGAGCAGATTGTTTGAGCAAGTGGGTTGGTGAATCTGAAAGGC
AACTTAGGCTTCTTTTTGATCAGGCATATTTGATGAGACCTTCTATAATATTTTTTGATGAAATAGATGGATTAGCTCCAGTTCGCTCTA
GCAGACAAGATCAGATCCACAGCTCTATAGTATCAACCCTCCTTGCTCTTATGGATGGATTAGATAATAGGGGTGAAATTGTTGTTATTG
GTGCTACAAACAGACTTGACTCTATAGATCCTGCACTCAGGAGACCTGGTCGTTTTGACAGAGAATTCCTCTTCAACCTGCCTGATCAAA
AGGCAAGAAAACACATCTTACAGATCCATACCAGGGACTGGAATCCAAAATTGTCAGATGCATTTTTAGGTGAATTGGCTGAAAAATGTG
TTGGCTACTGTGGAGCCGATATCAAGGCCCTGTGCACTGAAGCCGCCCTGATTGCACTGCGGAGGCGTTATCCCCAGATCTATGCTAGCA
GTCATAAACTGCAGCTGGATGTTTCCTCAATAGTGCTTAGTGCCCAAGATTTTTACCATGCAATGCAGAATATCGTGCCTGCTTCCCAAC
GTGCTGTGATGTCTTCAGGGCATGCACTATCCCCCATCATAAGACCACTGCTGGAAAGAAGCTTCAACAACATCCTAGCAGTCTTGCAAA
AAGTGTTTCCTCATGCTGAAATTAGCCAGAGTGACAAAAAAGAAGATATAGAAACTTTAATTTTAGAGGATAGTGAAGATGAAAATGCTT
TATCAATTTTTGAGACCAATTGTCACTCAGGATCACCAAAGAAACAGTCATCATCTGCTGCTATACATAAACCCTACCTTCATTTTACAA
TGTCACCATATCATCAGCCAACCTCTTACAGGCCACGCTTATTGCTCTCTGGAGAACGGGGCTCAGGTCAAACTTCTCACCTTGCTCCAG
CACTTTTGCACACTCTAGAAAGATTCTCTGTGCATAGACTAGATCTCCCAGCACTTTATTCAGTTAGTGCCAAAACACCTGAGGAATCAT
GTGCACAGATTTTTCGTGAAGCTCGAAGAACAGTACCTAGTATTGTTTACATGCCTCACATTGGGGATTGGTGGGAAGCTGTCAGTGAAA
CTGTGAGAGCAACTTTTCTGACATTGCTACAAGATATACCATCATTTTCACCTATATTTTTATTGTCTACCTCTGAAACCATGTACAGTG
AACTGCCTGAAGAGATTTCCTGGGTCGTACTGAAATTCCAGTGGCAAAAATTCGAACAGAACAGGAAAGCAAAGGCCCTATGACCCGCCG
ACTGCTGCTGCATGAGGTCCCCACCGGGGAGGTCTGGGTCCGTTTTGACCTGCAGCTTTTTGAGCAAAAAACTCTCCTGTAGGGGTTCTA
AAGGACAGCACCAGCGGGACAGCCCACAAGGCTGGGGCTGGAGAATGAGAGACTGCGCTCTCTTGGGGCTGAGGGAGCACCATGCAGCTT
CACCCCTCACAAAGCCATGCACGCTGGGGGCTCTGTTTTCCTGCACACTAAATAGCTAGCAATCTATGCAAACACCTTTCCCATAAAGAA
ACCAAACCCCATAGTACAGTGCCTTGTCCTAGTGTTCACATGTTCAGCTCTGTTTGTTTAGATGCCAAGGTTTCCATTTTCAGGGCTATA
AAAAGTATTACTTGGAAATGAGGCATCAGACCACCAGATGTTACCGCTCGGTTGAATGTGTCCACCGTGGAGTGGTTTGGTGACGCTGTA
ACCATTCCACGCCAGTGACCTCTGCTGGGTCACAGCCACTCAGGAGGGGAAGGGTCAGGATGAGAGGCTGCAGCCTCGACACTTGGCGCG
GCCTGATACTGAAATAGCGTCTACTCGTGCACTGAATAAAAACAGAAACTTGATCATTTTATTCCTGATTAGATTTTATCACTCTCTGCT
AAGACAATATAGTCTGGAGTATAAGTGGGAAAGCTTGATTTAAATACTGTGAACTCTAATAATGTGGAAAATATTTTTCAACTTTAATTT
TCTGAAGTATAAATTATTTATGTAAATTCATTGTTTTTGCATATTTCTTAGGACATGCATCTTTAAGCTTTATCATTGCCCATATGTACA

>7338_7338_1_ATAD2B-ITSN2_ATAD2B_chr2_24021008_ENST00000238789_ITSN2_chr2_24426652_ENST00000355123_length(amino acids)=926AA_BP=904
MTGRRAGLARLSRARRGLRPPGWTMVNTRKSSLRLLGSKSPGPGPGPGAGAEPGATGGSSHFISSRTRSSKTRAASCPAAKAGGSGGAGV
TLDEARKVEVDGSLSDSHVSPPAKRTLKQPDSVCKDKSKSRSTGQREEWNLSTGQARLTSQPGATLPNGHSGLSLRSHPLRGEKKGDGDL
SCINGDMEVRKSCRSRKNRFESVNQSLLFDQLVNSTAEAVLQEMDNINIRQNRRSGEVERLRMWTDTEFENMDMYSRVKRRRKSLRRNSY
GIQNHHEVSTEGEEEESQEEDGDIEVEEAEGEENDRPYNLRQRKTVDRYQAPPIVPAHQKKRENTLFDIHRSPARRSHIRRKKHAIHSSD
TTSSDEERFERRKSKSMARARNRCLPMNFRAEDLASGILRERVKVGASLADVDPMNIDKSVRFDSIGGLSHHIHALKEMVVFPLLYPEIF
EKFKIQPPRGCLFYGPPGTGKTLVARALANECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVRSS
RQDQIHSSIVSTLLALMDGLDNRGEIVVIGATNRLDSIDPALRRPGRFDREFLFNLPDQKARKHILQIHTRDWNPKLSDAFLGELAEKCV
GYCGADIKALCTEAALIALRRRYPQIYASSHKLQLDVSSIVLSAQDFYHAMQNIVPASQRAVMSSGHALSPIIRPLLERSFNNILAVLQK
VFPHAEISQSDKKEDIETLILEDSEDENALSIFETNCHSGSPKKQSSSAAIHKPYLHFTMSPYHQPTSYRPRLLLSGERGSGQTSHLAPA
LLHTLERFSVHRLDLPALYSVSAKTPEESCAQIFREARRTVPSIVYMPHIGDWWEAVSETVRATFLTLLQDIPSFSPIFLLSTSETMYSE

--------------------------------------------------------------
>7338_7338_2_ATAD2B-ITSN2_ATAD2B_chr2_24021008_ENST00000238789_ITSN2_chr2_24426652_ENST00000361999_length(transcript)=3904nt_BP=2984nt
CCTGCGGCGCTGGAGCCTTGACGCACGGAGCTCGAGAGCGAGAACGGGAGAGAAAGGGGTAGAAATGGCGGCTCCGCTCGGCTCCCGCTG
AGGAGGGCGAAGCCGGCGGAGTGTCTGTGCTGCCGGTCTGCAGCACCGCCCCCGCTTCCCGCACGCCGCCTGCTCACGCCGACTTCCCTT
CCTCTGCCCGGCTCTCTCTTGTGCTCGTCTGCGCTCCGCACGCTCCGGGCCGGCTCGTCTCTCATTGCCCGGCTCGGCTCCGCTGGCCCT
GACTGACCGGCCGGCGGGCCGGCCTTGCTCGGCTCTCCCGGGCGCGGCGTGGACTCCGTCCCCCTGGCTGGACCATGGTGAACACCCGGA
AGAGCTCTCTCCGCCTTCTCGGGTCCAAGTCTCCTGGTCCCGGGCCTGGGCCTGGGGCCGGAGCAGAGCCTGGGGCGACCGGAGGCAGCA
GCCATTTCATCTCCTCTCGGACCCGCTCCTCCAAGACCCGCGCCGCCAGCTGCCCCGCCGCCAAAGCCGGGGGAAGCGGTGGCGCCGGCG
TCACTCTGGATGAGGCCAGGAAAGTTGAAGTTGATGGTAGTTTAAGTGATAGCCACGTATCTCCTCCAGCCAAACGCACTTTGAAACAAC
CTGATTCTGTTTGCAAAGACAAATCAAAATCACGAAGTACTGGTCAGCGAGAGGAATGGAACTTATCAACTGGACAGGCCAGGTTAACTT
CTCAGCCTGGTGCTACATTACCAAATGGACATAGTGGCTTATCCCTTCGAAGCCATCCCCTTCGAGGGGAAAAGAAGGGAGATGGGGACC
TTTCTTGTATAAATGGTGACATGGAAGTCAGAAAAAGTTGTCGTTCCAGGAAAAACAGATTTGAAAGTGTGAACCAGAGTTTGTTATTTG
ATCAACTAGTAAATAGCACTGCTGAAGCTGTACTACAGGAAATGGACAACATTAACATCCGACAGAATCGTCGATCAGGAGAAGTAGAAC
GACTTCGAATGTGGACAGATACAGAATTTGAAAACATGGATATGTATTCAAGAGTGAAAAGGCGAAGAAAGTCACTAAGAAGAAATAGTT
ATGGGATACAAAATCATCATGAAGTTTCTACTGAGGGTGAAGAAGAAGAATCTCAAGAGGAGGATGGAGATATAGAAGTTGAAGAGGCAG
AAGGAGAAGAAAATGATAGACCATATAATTTGAGACAGAGAAAAACAGTGGATCGATACCAAGCACCTCCAATAGTACCAGCTCATCAAA
AAAAGAGGGAAAACACGCTGTTTGATATTCATAGATCTCCAGCAAGAAGAAGCCATATTAGGAGAAAGAAGCATGCCATTCATAGTAGTG
ACACAACTTCTTCTGATGAGGAACGCTTTGAAAGAAGGAAATCAAAGAGCATGGCAAGAGCAAGAAATAGATGTTTGCCTATGAACTTCA
GAGCAGAGGACTTAGCTAGCGGTATTCTCCGAGAACGAGTGAAAGTGGGTGCAAGCTTGGCTGATGTTGATCCAATGAACATTGATAAAT
CAGTACGGTTTGATAGCATAGGTGGATTGAGCCATCATATTCATGCGCTAAAGGAAATGGTAGTATTCCCACTTTTATATCCAGAAATTT
TTGAAAAGTTTAAAATTCAGCCTCCAAGGGGCTGTTTGTTTTATGGCCCTCCTGGCACAGGTAAAACCTTGGTTGCCAGAGCATTAGCTA
ATGAATGCAGCCAAGGAGACAAAAAAGTGGCTTTTTTTATGCGAAAAGGAGCAGATTGTTTGAGCAAGTGGGTTGGTGAATCTGAAAGGC
AACTTAGGCTTCTTTTTGATCAGGCATATTTGATGAGACCTTCTATAATATTTTTTGATGAAATAGATGGATTAGCTCCAGTTCGCTCTA
GCAGACAAGATCAGATCCACAGCTCTATAGTATCAACCCTCCTTGCTCTTATGGATGGATTAGATAATAGGGGTGAAATTGTTGTTATTG
GTGCTACAAACAGACTTGACTCTATAGATCCTGCACTCAGGAGACCTGGTCGTTTTGACAGAGAATTCCTCTTCAACCTGCCTGATCAAA
AGGCAAGAAAACACATCTTACAGATCCATACCAGGGACTGGAATCCAAAATTGTCAGATGCATTTTTAGGTGAATTGGCTGAAAAATGTG
TTGGCTACTGTGGAGCCGATATCAAGGCCCTGTGCACTGAAGCCGCCCTGATTGCACTGCGGAGGCGTTATCCCCAGATCTATGCTAGCA
GTCATAAACTGCAGCTGGATGTTTCCTCAATAGTGCTTAGTGCCCAAGATTTTTACCATGCAATGCAGAATATCGTGCCTGCTTCCCAAC
GTGCTGTGATGTCTTCAGGGCATGCACTATCCCCCATCATAAGACCACTGCTGGAAAGAAGCTTCAACAACATCCTAGCAGTCTTGCAAA
AAGTGTTTCCTCATGCTGAAATTAGCCAGAGTGACAAAAAAGAAGATATAGAAACTTTAATTTTAGAGGATAGTGAAGATGAAAATGCTT
TATCAATTTTTGAGACCAATTGTCACTCAGGATCACCAAAGAAACAGTCATCATCTGCTGCTATACATAAACCCTACCTTCATTTTACAA
TGTCACCATATCATCAGCCAACCTCTTACAGGCCACGCTTATTGCTCTCTGGAGAACGGGGCTCAGGTCAAACTTCTCACCTTGCTCCAG
CACTTTTGCACACTCTAGAAAGATTCTCTGTGCATAGACTAGATCTCCCAGCACTTTATTCAGTTAGTGCCAAAACACCTGAGGAATCAT
GTGCACAGATTTTTCGTGAAGCTCGAAGAACAGTACCTAGTATTGTTTACATGCCTCACATTGGGGATTGGTGGGAAGCTGTCAGTGAAA
CTGTGAGAGCAACTTTTCTGACATTGCTACAAGATATACCATCATTTTCACCTATATTTTTATTGTCTACCTCTGAAACCATGTACAGTG
AACTGCCTGAAGAGATTTCCTGGGTCGTACTGAAATTCCAGTGGCAAAAATTCGAACAGAACAGGAAAGCAAAGGCCCTATGACCCGCCG
ACTGCTGCTGCATGAGGTCCCCACCGGGGAGGTCTGGGTCCGTTTTGACCTGCAGCTTTTTGAGCAAAAAACTCTCCTGTAGGGGTTCTA
AAGGACAGCACCAGCGGGACAGCCCACAAGGCTGGGGCTGGAGAATGAGAGACTGCGCTCTCTTGGGGCTGAGGGAGCACCATGCAGCTT
CACCCCTCACAAAGCCATGCACGCTGGGGGCTCTGTTTTCCTGCACACTAAATAGCTAGCAATCTATGCAAACACCTTTCCCATAAAGAA
ACCAAACCCCATAGTACAGTGCCTTGTCCTAGTGTTCACATGTTCAGCTCTGTTTGTTTAGATGCCAAGGTTTCCATTTTCAGGGCTATA
AAAAGTATTACTTGGAAATGAGGCATCAGACCACCAGATGTTACCGCTCGGTTGAATGTGTCCACCGTGGAGTGGTTTGGTGACGCTGTA
ACCATTCCACGCCAGTGACCTCTGCTGGGTCACAGCCACTCAGGAGGGGAAGGGTCAGGATGAGAGGCTGCAGCCTCGACACTTGGCGCG
GCCTGATACTGAAATAGCGTCTACTCGTGCACTGAATAAAAACAGAAACTTGATCATTTTATTCCTGATTAGATTTTATCACTCTCTGCT
AAGACAATATAGTCTGGAGTATAAGTGGGAAAGCTTGATTTAAATACTGTGAACTCTAATAATGTGGAAAATATTTTTCAACTTTAATTT
TCTGAAGTATAAATTATTTATGTAAATTCATTGTTTTTGCATATTTCTTAGGACATGCATCTTTAAGCTTTATCATTGCCCATATGTACA

>7338_7338_2_ATAD2B-ITSN2_ATAD2B_chr2_24021008_ENST00000238789_ITSN2_chr2_24426652_ENST00000361999_length(amino acids)=926AA_BP=904
MTGRRAGLARLSRARRGLRPPGWTMVNTRKSSLRLLGSKSPGPGPGPGAGAEPGATGGSSHFISSRTRSSKTRAASCPAAKAGGSGGAGV
TLDEARKVEVDGSLSDSHVSPPAKRTLKQPDSVCKDKSKSRSTGQREEWNLSTGQARLTSQPGATLPNGHSGLSLRSHPLRGEKKGDGDL
SCINGDMEVRKSCRSRKNRFESVNQSLLFDQLVNSTAEAVLQEMDNINIRQNRRSGEVERLRMWTDTEFENMDMYSRVKRRRKSLRRNSY
GIQNHHEVSTEGEEEESQEEDGDIEVEEAEGEENDRPYNLRQRKTVDRYQAPPIVPAHQKKRENTLFDIHRSPARRSHIRRKKHAIHSSD
TTSSDEERFERRKSKSMARARNRCLPMNFRAEDLASGILRERVKVGASLADVDPMNIDKSVRFDSIGGLSHHIHALKEMVVFPLLYPEIF
EKFKIQPPRGCLFYGPPGTGKTLVARALANECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVRSS
RQDQIHSSIVSTLLALMDGLDNRGEIVVIGATNRLDSIDPALRRPGRFDREFLFNLPDQKARKHILQIHTRDWNPKLSDAFLGELAEKCV
GYCGADIKALCTEAALIALRRRYPQIYASSHKLQLDVSSIVLSAQDFYHAMQNIVPASQRAVMSSGHALSPIIRPLLERSFNNILAVLQK
VFPHAEISQSDKKEDIETLILEDSEDENALSIFETNCHSGSPKKQSSSAAIHKPYLHFTMSPYHQPTSYRPRLLLSGERGSGQTSHLAPA
LLHTLERFSVHRLDLPALYSVSAKTPEESCAQIFREARRTVPSIVYMPHIGDWWEAVSETVRATFLTLLQDIPSFSPIFLLSTSETMYSE

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Top

Fusion Gene PPI Analysis for ATAD2B-ITSN2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ATAD2B-ITSN2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for ATAD2B-ITSN2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source