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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ATAD2B-MMP15 (FusionGDB2 ID:7340)

Fusion Gene Summary for ATAD2B-MMP15

Fusion gene summary

Fusion gene information	Fusion gene name: ATAD2B-MMP15
	Fusion gene ID: 7340
		Hgene	Tgene
	Gene symbol	ATAD2B	MMP15
	Gene ID	54454	4324
	Gene name	ATPase family AAA domain containing 2B	matrix metallopeptidase 15
	Synonyms	-	MMP-15\|MT2-MMP\|MT2MMP\|MTMMP2\|SMCP-2
	Cytomap	2p24.1-p23.3	16q21
	Type of gene	protein-coding	protein-coding
	Description	ATPase family AAA domain-containing protein 2B	matrix metalloproteinase-15MT-MMP 2matrix metallopeptidase 15 (membrane-inserted)matrix metalloproteinase 15 (membrane-inserted)membrane-type matrix metalloproteinase 2membrane-type-2 matrix metalloproteinase
	Modification date	20200313	20200313
	UniProtAcc	Q9ULI0	P51511
	Ensembl transtripts involved in fusion gene	ENST00000238789, ENST00000474583,	ENST00000219271,
Fusion gene scores	* DoF score	7 X 7 X 4=196	1 X 1 X 1=1
	# samples	7	1
	** MAII score	log2(7/196*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(1/1*10)=3.32192809488736
Context	PubMed: ATAD2B [Title/Abstract] AND MMP15 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ATAD2B(24056788)-MMP15(58071375), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across ATAD2B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MMP15 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	219N	ATAD2B	chr2	24056788	-	MMP15	chr16	58071375	+

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Fusion Gene ORF analysis for ATAD2B-MMP15

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000238789	ENST00000219271	ATAD2B	chr2	24056788	-	MMP15	chr16	58071375	+
intron-3CDS	ENST00000474583	ENST00000219271	ATAD2B	chr2	24056788	-	MMP15	chr16	58071375	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000238789

ATAD2B

chr2

24056788

ENST00000219271

MMP15

chr16

58071375

5375

2072

272

3919

1215

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000238789	ENST00000219271	ATAD2B	chr2	24056788	-	MMP15	chr16	58071375	+	0.001532072	0.99846786

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Fusion Genomic Features for ATAD2B-MMP15

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ATAD2B	chr2	24056788	-	MMP15	chr16	58071375	+	6.12E-05	0.99993885
ATAD2B	chr2	24056788	-	MMP15	chr16	58071375	+	6.12E-05	0.99993885

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ATAD2B-MMP15

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:24056788/chr16:58071375)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ATAD2B Q9ULI0	MMP15 P51511
	FUNCTION: Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A. {ECO:0000269\|PubMed:9461298}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ATAD2B

chr2:24056788

chr16:58071375

ENST00000238789

257_262

576

1459.0

Compositional bias

Note=Poly-Glu

Hgene

ATAD2B

chr2:24056788

chr16:58071375

ENST00000238789

441_448

576

1459.0

Nucleotide binding

ATP

Tgene

MMP15

chr2:24056788

chr16:58071375

ENST00000219271

331_340

670.0

Compositional bias

Note=Poly-Pro

Tgene

MMP15

chr2:24056788

chr16:58071375

ENST00000219271

109_116

670.0

Motif

Cysteine switch

Tgene

MMP15

chr2:24056788

chr16:58071375

ENST00000219271

367_415

670.0

Repeat

Note=Hemopexin 1

Tgene

MMP15

chr2:24056788

chr16:58071375

ENST00000219271

416_461

670.0

Repeat

Note=Hemopexin 2

Tgene

MMP15

chr2:24056788

chr16:58071375

ENST00000219271

463_511

670.0

Repeat

Note=Hemopexin 3

Tgene

MMP15

chr2:24056788

chr16:58071375

ENST00000219271

512_559

670.0

Repeat

Note=Hemopexin 4

Tgene

MMP15

chr2:24056788

chr16:58071375

ENST00000219271

132_625

670.0

Topological domain

Extracellular

Tgene

MMP15

chr2:24056788

chr16:58071375

ENST00000219271

647_669

670.0

Topological domain

Cytoplasmic

Tgene

MMP15

chr2:24056788

chr16:58071375

ENST00000219271

626_646

670.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ATAD2B

chr2:24056788

chr16:58071375

ENST00000238789

943_974

576

1459.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ATAD2B

chr2:24056788

chr16:58071375

ENST00000238789

1247_1250

576

1459.0

Compositional bias

Note=Poly-Ser

Hgene

ATAD2B

chr2:24056788

chr16:58071375

ENST00000238789

975_1045

576

1459.0

Domain

Bromo

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Fusion Gene Sequence for ATAD2B-MMP15

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>7340_7340_1_ATAD2B-MMP15_ATAD2B_chr2_24056788_ENST00000238789_MMP15_chr16_58071375_ENST00000219271_length(transcript)=5375nt_BP=2072nt
CCTGCGGCGCTGGAGCCTTGACGCACGGAGCTCGAGAGCGAGAACGGGAGAGAAAGGGGTAGAAATGGCGGCTCCGCTCGGCTCCCGCTG
AGGAGGGCGAAGCCGGCGGAGTGTCTGTGCTGCCGGTCTGCAGCACCGCCCCCGCTTCCCGCACGCCGCCTGCTCACGCCGACTTCCCTT
CCTCTGCCCGGCTCTCTCTTGTGCTCGTCTGCGCTCCGCACGCTCCGGGCCGGCTCGTCTCTCATTGCCCGGCTCGGCTCCGCTGGCCCT
GACTGACCGGCCGGCGGGCCGGCCTTGCTCGGCTCTCCCGGGCGCGGCGTGGACTCCGTCCCCCTGGCTGGACCATGGTGAACACCCGGA
AGAGCTCTCTCCGCCTTCTCGGGTCCAAGTCTCCTGGTCCCGGGCCTGGGCCTGGGGCCGGAGCAGAGCCTGGGGCGACCGGAGGCAGCA
GCCATTTCATCTCCTCTCGGACCCGCTCCTCCAAGACCCGCGCCGCCAGCTGCCCCGCCGCCAAAGCCGGGGGAAGCGGTGGCGCCGGCG
TCACTCTGGATGAGGCCAGGAAAGTTGAAGTTGATGGTAGTTTAAGTGATAGCCACGTATCTCCTCCAGCCAAACGCACTTTGAAACAAC
CTGATTCTGTTTGCAAAGACAAATCAAAATCACGAAGTACTGGTCAGCGAGAGGAATGGAACTTATCAACTGGACAGGCCAGGTTAACTT
CTCAGCCTGGTGCTACATTACCAAATGGACATAGTGGCTTATCCCTTCGAAGCCATCCCCTTCGAGGGGAAAAGAAGGGAGATGGGGACC
TTTCTTGTATAAATGGTGACATGGAAGTCAGAAAAAGTTGTCGTTCCAGGAAAAACAGATTTGAAAGTGTGAACCAGAGTTTGTTATTTG
ATCAACTAGTAAATAGCACTGCTGAAGCTGTACTACAGGAAATGGACAACATTAACATCCGACAGAATCGTCGATCAGGAGAAGTAGAAC
GACTTCGAATGTGGACAGATACAGAATTTGAAAACATGGATATGTATTCAAGAGTGAAAAGGCGAAGAAAGTCACTAAGAAGAAATAGTT
ATGGGATACAAAATCATCATGAAGTTTCTACTGAGGGTGAAGAAGAAGAATCTCAAGAGGAGGATGGAGATATAGAAGTTGAAGAGGCAG
AAGGAGAAGAAAATGATAGACCATATAATTTGAGACAGAGAAAAACAGTGGATCGATACCAAGCACCTCCAATAGTACCAGCTCATCAAA
AAAAGAGGGAAAACACGCTGTTTGATATTCATAGATCTCCAGCAAGAAGAAGCCATATTAGGAGAAAGAAGCATGCCATTCATAGTAGTG
ACACAACTTCTTCTGATGAGGAACGCTTTGAAAGAAGGAAATCAAAGAGCATGGCAAGAGCAAGAAATAGATGTTTGCCTATGAACTTCA
GAGCAGAGGACTTAGCTAGCGGTATTCTCCGAGAACGAGTGAAAGTGGGTGCAAGCTTGGCTGATGTTGATCCAATGAACATTGATAAAT
CAGTACGGTTTGATAGCATAGGTGGATTGAGCCATCATATTCATGCGCTAAAGGAAATGGTAGTATTCCCACTTTTATATCCAGAAATTT
TTGAAAAGTTTAAAATTCAGCCTCCAAGGGGCTGTTTGTTTTATGGCCCTCCTGGCACAGGTAAAACCTTGGTTGCCAGAGCATTAGCTA
ATGAATGCAGCCAAGGAGACAAAAAAGTGGCTTTTTTTATGCGAAAAGGAGCAGATTGTTTGAGCAAGTGGGTTGGTGAATCTGAAAGGC
AACTTAGGCTTCTTTTTGATCAGGCATATTTGATGAGACCTTCTATAATATTTTTTGATGAAATAGATGGATTAGCTCCAGTTCGCTCTA
GCAGACAAGATCAGATCCACAGCTCTATAGTATCAACCCTCCTTGCTCTTATGGATGGATTAGATAATAGGGGTGAAATTGTTGTTATTG
GTGCTACAAACAGACTTGACTCTATAGATCCTGCACTCAGGAGACCTGGTCGTTTTGACAGAGAATTCCTCTTCAACCTGCCTGATCAAA
AGAACTGGCTGCGGCTTTATGGCTACCTGCCTCAGCCCAGCCGCCATATGTCCACCATGCGTTCCGCCCAGATCTTGGCCTCGGCCCTTG
CAGAGATGCAGCGCTTCTACGGGATCCCAGTCACCGGTGTGCTCGACGAAGAGACCAAGGAGTGGATGAAGCGGCCCCGCTGTGGGGTGC
CAGACCAGTTCGGGGTACGAGTGAAAGCCAACCTGCGGCGGCGTCGGAAGCGCTACGCCCTCACCGGGAGGAAGTGGAACAACCACCATC
TGACCTTTAGCATCCAGAACTACACGGAGAAGTTGGGCTGGTACCACTCGATGGAGGCGGTGCGCAGGGCCTTCCGCGTGTGGGAGCAGG
CCACGCCCCTGGTCTTCCAGGAGGTGCCCTATGAGGACATCCGGCTGCGGCGACAGAAGGAGGCCGACATCATGGTACTCTTTGCCTCTG
GCTTCCACGGCGACAGCTCGCCGTTTGATGGCACCGGTGGCTTTCTGGCCCACGCCTATTTCCCTGGCCCCGGCCTAGGCGGGGACACCC
ATTTTGACGCAGATGAGCCCTGGACCTTCTCCAGCACTGACCTGCATGGAAACAACCTCTTCCTGGTGGCAGTGCATGAGCTGGGCCACG
CGCTGGGGCTGGAGCACTCCAGCAACCCCAATGCCATCATGGCGCCGTTCTACCAGTGGAAGGACGTTGACAACTTCAAGCTGCCCGAGG
ACGATCTCCGTGGCATCCAGCAGCTCTACGGTACCCCAGACGGTCAGCCACAGCCTACCCAGCCTCTCCCCACTGTGACGCCACGGCGGC
CAGGCCGGCCTGACCACCGGCCGCCCCGGCCTCCCCAGCCACCACCCCCAGGTGGGAAGCCAGAGCGGCCCCCAAAGCCGGGCCCCCCAG
TCCAGCCCCGAGCCACAGAGCGGCCCGACCAGTATGGCCCCAACATCTGCGACGGGGACTTTGACACAGTGGCCATGCTTCGCGGGGAGA
TGTTCGTGTTCAAGGGCCGCTGGTTCTGGCGAGTCCGGCACAACCGCGTCCTGGACAACTATCCCATGCCCATCGGGCACTTCTGGCGTG
GTCTGCCCGGTGACATCAGTGCTGCCTACGAGCGCCAAGACGGTCGTTTTGTCTTTTTCAAAGGTGACCGCTACTGGCTCTTTCGAGAAG
CGAACCTGGAGCCCGGCTACCCACAGCCGCTGACCAGCTATGGCCTGGGCATCCCCTATGACCGCATTGACACGGCCATCTGGTGGGAGC
CCACAGGCCACACCTTCTTCTTCCAAGAGGACAGGTACTGGCGCTTCAACGAGGAGACACAGCGTGGAGACCCTGGGTACCCCAAGCCCA
TCAGTGTCTGGCAGGGGATCCCTGCCTCCCCTAAAGGGGCCTTCCTGAGCAATGACGCAGCCTACACCTACTTCTACAAGGGCACCAAAT
ACTGGAAATTCGACAATGAGCGCCTGCGGATGGAGCCCGGCTACCCCAAGTCCATCCTGCGGGACTTCATGGGCTGCCAGGAGCACGTGG
AGCCAGGCCCCCGATGGCCCGACGTGGCCCGGCCGCCCTTCAACCCCCACGGGGGTGCAGAGCCCGGGGCGGACAGCGCAGAGGGCGACG
TGGGGGATGGGGATGGGGACTTTGGGGCCGGGGTCAACAAGGACGGGGGCAGCCGCGTGGTGGTGCAGATGGAGGAGGTGGCACGGACGG
TGAACGTGGTGATGGTGCTGGTGCCACTGCTGCTGCTGCTCTGCGTCCTGGGCCTCACCTACGCGCTGGTGCAGATGCAGCGCAAGGGTG
CGCCACGTGTCCTGCTTTACTGCAAGCGCTCGCTGCAGGAGTGGGTCTGACCACCCAGCGCTCCTGCTAACGGTGCTCAGGGGGCGCCTG
TGGTTCTGAGATGGCTCCCAGGGGCTCCCTCCGCCCCCAGGTAGGGGCCCCTCTCAGCCCTCACACACCCTGTCTGCCCCGCCCTCATTA
TTTATGTCCAGGTGTTTGTTTTGTTTTGTTTTTGGCACCTTACTTGACCATTTGTTTCTGTTTCCCCGACTGGGGCAGGGTGTTTAGAAT
TTTCTAAATGTAGTTCTGCTCCAGACAGGGAATTAGGCCCCCATCATCCTCTGGCTTGGCCACAGCCAGGGGAGCAGAGGGGCAGAGGCC
CACATTGGAAGAGCAGCACCTCCTCAGCCTGAACCCCAGGGCTGTAACTGCCAGGCTCTCTTTGCCCAGTTGGAGACTGTCTGGCCCCCC
TGGTCCCCTCCTTCCCAAGTGAGTCTCTCTGGGCCTTAGGAAGAGCCTTCCACCCAGGGGCAGCCCCAGGCCAAAGGGGACCTGGAAGGG
AGGTGGGCCGTGGCCCTTGAGTCCCCATTGAGGCTTGGTTCCTTCCCAATCCAGTGGACTTCGCAGTCCACTTCTGACAGCCTCAGTGAC
CCTGGCTCCTTGTGCCAGAGAACCCAGCCCACCCCCGGCAGCAGCCCCCAGCTCCCACCTCCCCTTGGGCCCACACCTCCTTCCCTCTCT
GGAGAAAGGGCCCTGGGCCTGCCTCACCACGGACCAAAGGGAGTCTGCCAGGGCCCCTCTCCCCAGGGAAGCAGCAGCCTCGCCCCTGGC
AGAGATGCCTCCCTGAGCTAGAACCCTCTGTTCCTTCCCTGTGCCTCCTCCCTCCCTCTCCGACTCACACCACTAGCCTCAGGGGTCTGA
GCTCCAGCTCCTTTGGGCTTCAGCTGCCAGTGTCCTGAGCCCCAGGGAGAGGGGGCTGGTGGGTGCCTAGGCCTGGGCAGTGGATGGCCG
TGAATGGGTGCCCACAGTGTCAGGCACTGGGCATGAGGGGTTCCTCCCCTCCAGCTCCCTGTGCCCCCAGGGTCCTGGGAGGAGAGACAC
TGGTGGGGATAGGCCAGCCGCGCATCAGACTGTGAACCCCACGAAGGAGCCCATTGTGGCCTAAGAGGCTGCCCTCCTGTGCTCAGCCCT
GAGGACAGATGCCTCCTTCCTCTTTTCCTTCCCAAAGCAAGCAAGAGGCCGTGGCTGCTGTGGGAAATGGTACTGTACAGCTGGCTCTAC
TTCCCCATGGCCCTGAGCGAGTGGAGTCTGCCACCCAGGATCCCCAAGGCACTTGAGGGGGAAGGATTCTGCTGGCCTCTGCGAGTGGTT
TCTTGTGCACTGGCACCAAGTGCGGGTCCGGCAGCTTCTGCCCCCTGCAGAACCGGAGAGCCAGCTAAGGGGTGGGGCTGCGGGGGTTCC

>7340_7340_1_ATAD2B-MMP15_ATAD2B_chr2_24056788_ENST00000238789_MMP15_chr16_58071375_ENST00000219271_length(amino acids)=1215AA_BP=600
MTGRRAGLARLSRARRGLRPPGWTMVNTRKSSLRLLGSKSPGPGPGPGAGAEPGATGGSSHFISSRTRSSKTRAASCPAAKAGGSGGAGV
TLDEARKVEVDGSLSDSHVSPPAKRTLKQPDSVCKDKSKSRSTGQREEWNLSTGQARLTSQPGATLPNGHSGLSLRSHPLRGEKKGDGDL
SCINGDMEVRKSCRSRKNRFESVNQSLLFDQLVNSTAEAVLQEMDNINIRQNRRSGEVERLRMWTDTEFENMDMYSRVKRRRKSLRRNSY
GIQNHHEVSTEGEEEESQEEDGDIEVEEAEGEENDRPYNLRQRKTVDRYQAPPIVPAHQKKRENTLFDIHRSPARRSHIRRKKHAIHSSD
TTSSDEERFERRKSKSMARARNRCLPMNFRAEDLASGILRERVKVGASLADVDPMNIDKSVRFDSIGGLSHHIHALKEMVVFPLLYPEIF
EKFKIQPPRGCLFYGPPGTGKTLVARALANECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVRSS
RQDQIHSSIVSTLLALMDGLDNRGEIVVIGATNRLDSIDPALRRPGRFDREFLFNLPDQKNWLRLYGYLPQPSRHMSTMRSAQILASALA
EMQRFYGIPVTGVLDEETKEWMKRPRCGVPDQFGVRVKANLRRRRKRYALTGRKWNNHHLTFSIQNYTEKLGWYHSMEAVRRAFRVWEQA
TPLVFQEVPYEDIRLRRQKEADIMVLFASGFHGDSSPFDGTGGFLAHAYFPGPGLGGDTHFDADEPWTFSSTDLHGNNLFLVAVHELGHA
LGLEHSSNPNAIMAPFYQWKDVDNFKLPEDDLRGIQQLYGTPDGQPQPTQPLPTVTPRRPGRPDHRPPRPPQPPPPGGKPERPPKPGPPV
QPRATERPDQYGPNICDGDFDTVAMLRGEMFVFKGRWFWRVRHNRVLDNYPMPIGHFWRGLPGDISAAYERQDGRFVFFKGDRYWLFREA
NLEPGYPQPLTSYGLGIPYDRIDTAIWWEPTGHTFFFQEDRYWRFNEETQRGDPGYPKPISVWQGIPASPKGAFLSNDAAYTYFYKGTKY
WKFDNERLRMEPGYPKSILRDFMGCQEHVEPGPRWPDVARPPFNPHGGAEPGADSAEGDVGDGDGDFGAGVNKDGGSRVVVQMEEVARTV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ATAD2B-MMP15

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ATAD2B-MMP15

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ATAD2B-MMP15

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source