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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RELB-TNFRSF8 (FusionGDB2 ID:73431)

Fusion Gene Summary for RELB-TNFRSF8

check button Fusion gene summary
Fusion gene informationFusion gene name: RELB-TNFRSF8
Fusion gene ID: 73431
HgeneTgene
Gene symbol

RELB

TNFRSF8

Gene ID

5971

943

Gene nameRELB proto-oncogene, NF-kB subunitTNF receptor superfamily member 8
SynonymsI-REL|IMD53|IREL|REL-BCD30|D1S166E|Ki-1
Cytomap

19q13.32

1p36.22

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor RelBv-rel avian reticuloendotheliosis viral oncogene homolog B (nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)v-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light polypeptide gentumor necrosis factor receptor superfamily member 8CD30L receptorKi-1 antigencytokine receptor CD30lymphocyte activation antigen CD30
Modification date2020031520200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000221452, ENST00000505236, 
ENST00000540120, 		ENST00000413146, 
ENST00000479933, ENST00000263932, 
ENST00000417814, 
Fusion gene scores* DoF score7 X 4 X 5=1405 X 6 X 5=150
# samples 85
** MAII scorelog2(8/140*10)=-0.807354922057604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/150*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RELB [Title/Abstract] AND TNFRSF8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRELB(45504943)-TNFRSF8(12175634), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTNFRSF8

GO:0042535

positive regulation of tumor necrosis factor biosynthetic process

16108830

TgeneTNFRSF8

GO:0043065

positive regulation of apoptotic process

16108830

TgeneTNFRSF8

GO:0045556

positive regulation of TRAIL biosynthetic process

16108830


check buttonFusion gene breakpoints across RELB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TNFRSF8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8295-01ARELBchr19

45504943

+TNFRSF8chr1

12175634

+


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Fusion Gene ORF analysis for RELB-TNFRSF8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000221452ENST00000413146RELBchr19

45504943

+TNFRSF8chr1

12175634

+
5CDS-intronENST00000221452ENST00000479933RELBchr19

45504943

+TNFRSF8chr1

12175634

+
5CDS-intronENST00000505236ENST00000413146RELBchr19

45504943

+TNFRSF8chr1

12175634

+
5CDS-intronENST00000505236ENST00000479933RELBchr19

45504943

+TNFRSF8chr1

12175634

+
5CDS-intronENST00000540120ENST00000413146RELBchr19

45504943

+TNFRSF8chr1

12175634

+
5CDS-intronENST00000540120ENST00000479933RELBchr19

45504943

+TNFRSF8chr1

12175634

+
In-frameENST00000221452ENST00000263932RELBchr19

45504943

+TNFRSF8chr1

12175634

+
In-frameENST00000221452ENST00000417814RELBchr19

45504943

+TNFRSF8chr1

12175634

+
In-frameENST00000505236ENST00000263932RELBchr19

45504943

+TNFRSF8chr1

12175634

+
In-frameENST00000505236ENST00000417814RELBchr19

45504943

+TNFRSF8chr1

12175634

+
In-frameENST00000540120ENST00000263932RELBchr19

45504943

+TNFRSF8chr1

12175634

+
In-frameENST00000540120ENST00000417814RELBchr19

45504943

+TNFRSF8chr1

12175634

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000221452RELBchr1945504943+ENST00000263932TNFRSF8chr112175634+29272561501250366
ENST00000221452RELBchr1945504943+ENST00000417814TNFRSF8chr112175634+18342561501247365
ENST00000540120RELBchr1945504943+ENST00000263932TNFRSF8chr112175634+29032321261226366
ENST00000540120RELBchr1945504943+ENST00000417814TNFRSF8chr112175634+18102321261223365
ENST00000505236RELBchr1945504943+ENST00000263932TNFRSF8chr112175634+28962251191219366
ENST00000505236RELBchr1945504943+ENST00000417814TNFRSF8chr112175634+18032251191216365

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000221452ENST00000263932RELBchr1945504943+TNFRSF8chr112175634+0.0282584060.9717416
ENST00000221452ENST00000417814RELBchr1945504943+TNFRSF8chr112175634+0.0489309950.95106894
ENST00000540120ENST00000263932RELBchr1945504943+TNFRSF8chr112175634+0.02803920.97196084
ENST00000540120ENST00000417814RELBchr1945504943+TNFRSF8chr112175634+0.0484135260.9515865
ENST00000505236ENST00000263932RELBchr1945504943+TNFRSF8chr112175634+0.028099470.9719006
ENST00000505236ENST00000417814RELBchr1945504943+TNFRSF8chr112175634+0.04901090.95098907

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Fusion Genomic Features for RELB-TNFRSF8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RELBchr1945504943+TNFRSF8chr112175633+3.98E-131
RELBchr1945504943+TNFRSF8chr112175633+3.98E-131

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for RELB-TNFRSF8


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:45504943/chr1:12175634)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTNFRSF8chr19:45504943chr1:12175634ENST0000041314605347_3770133.0Compositional biasNote=Pro/Ser/Thr-rich
TgeneTNFRSF8chr19:45504943chr1:12175634ENST0000041314605107_1500133.0RepeatNote=TNFR-Cys 3
TgeneTNFRSF8chr19:45504943chr1:12175634ENST0000041314605205_2410133.0RepeatNote=TNFR-Cys 4
TgeneTNFRSF8chr19:45504943chr1:12175634ENST0000041314605243_2810133.0RepeatNote=TNFR-Cys 5
TgeneTNFRSF8chr19:45504943chr1:12175634ENST0000041314605282_3250133.0RepeatNote=TNFR-Cys 6
TgeneTNFRSF8chr19:45504943chr1:12175634ENST000004131460528_660133.0RepeatNote=TNFR-Cys 1
TgeneTNFRSF8chr19:45504943chr1:12175634ENST000004131460568_1060133.0RepeatNote=TNFR-Cys 2
TgeneTNFRSF8chr19:45504943chr1:12175634ENST000004131460519_3850133.0Topological domainExtracellular
TgeneTNFRSF8chr19:45504943chr1:12175634ENST0000041314605407_5950133.0Topological domainCytoplasmic
TgeneTNFRSF8chr19:45504943chr1:12175634ENST0000041314605386_4060133.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRELBchr19:45504943chr1:12175634ENST00000221452+112125_44035580.0DomainRHD
HgeneRELBchr19:45504943chr1:12175634ENST00000540120+112125_44035580.0DomainRHD
HgeneRELBchr19:45504943chr1:12175634ENST00000221452+112433_43835580.0MotifNuclear localization signal
HgeneRELBchr19:45504943chr1:12175634ENST00000540120+112433_43835580.0MotifNuclear localization signal
HgeneRELBchr19:45504943chr1:12175634ENST00000221452+11240_6835580.0RegionNote=Leucine-zipper
HgeneRELBchr19:45504943chr1:12175634ENST00000540120+11240_6835580.0RegionNote=Leucine-zipper


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Fusion Gene Sequence for RELB-TNFRSF8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>73431_73431_1_RELB-TNFRSF8_RELB_chr19_45504943_ENST00000221452_TNFRSF8_chr1_12175634_ENST00000263932_length(transcript)=2927nt_BP=256nt
CCCGCCGCCCGCCCGGCCCGGCCCCGCGCCCCGCGCAGCCCCGGGCGCCGCGCGTCCTGCCCGGCCTGCGGCCCCAGCCCTTGCGCCGCT
CGTCCGACCCGCGATCGTCCACCAGACCGTGCCTCCCGGCCGCCCGGCCGGCCCGCGTGCATGCTTCGGTCTGGGCCAGCCTCTGGGCCG
TCCGTCCCCACTGGCCGGGCCATGCCGAGTCGCCGCGTCGCCAGACCGCCGGCTGCGCCGGAGCTGGGGGCCTTAGATGACCTTGTGGAG
AAGACGCCATGTGCATGGAACTCCTCCCGCACCTGCGAATGTCGACCTGGCATGATCTGTGCCACATCAGCCACCAACTCCCGTGCCCGC
TGTGTCCCCTACCCAATCTGTGCAGCAGAGACGGTCACCAAGCCCCAGGATATGGCTGAGAAGGACACCACCTTTGAGGCGCCACCCCTG
GGGACCCAGCCGGACTGCAACCCCACCCCAGAGAATGGCGAGGCGCCTGCCAGCACCAGCCCCACTCAGAGCTTGCTGGTGGACTCCCAG
GCCAGTAAGACGCTGCCCATCCCAACCAGCGCTCCCGTCGCTCTCTCCTCCACGGGGAAGCCCGTTCTGGATGCAGGGCCAGTGCTCTTC
TGGGTGATCCTGGTGTTGGTTGTGGTGGTCGGCTCCAGCGCCTTCCTCCTGTGCCACCGGAGGGCCTGCAGGAAGCGAATTCGGCAGAAG
CTCCACCTGTGCTACCCGGTCCAGACCTCCCAGCCCAAGCTAGAGCTTGTGGATTCCAGACCCAGGAGGAGCTCAACGCAGCTGAGGAGT
GGTGCGTCGGTGACAGAACCCGTCGCGGAAGAGCGAGGGTTAATGAGCCAGCCACTGATGGAGACCTGCCACAGCGTGGGGGCAGCCTAC
CTGGAGAGCCTGCCGCTGCAGGATGCCAGCCCGGCCGGGGGCCCCTCGTCCCCCAGGGACCTTCCTGAGCCCCGGGTGTCCACGGAGCAC
ACCAATAACAAGATTGAGAAAATCTACATCATGAAGGCTGACACCGTGATCGTGGGGACCGTGAAGGCTGAGCTGCCGGAGGGCCGGGGC
CTGGCGGGGCCAGCAGAGCCCGAGTTGGAGGAGGAGCTGGAGGCGGACCATACCCCCCACTACCCCGAGCAGGAGACAGAACCGCCTCTG
GGCAGCTGCAGCGATGTCATGCTCTCAGTGGAAGAGGAAGGGAAAGAAGACCCCTTGCCCACAGCTGCCTCTGGAAAGTGAGGCCTGGGC
TGGGCTGGGGCTAGGAGGGCAGCAGGGTGGCCTCTGGGAGGCCAGGATGGCACTGTTGGCACCGAGGTTGGGGGCAGAGGCCCATCTGGC
CTGAACTGAGGCTCCAGCATCTAGTGGTGGACCGGCCGGTCACTGCAGGGGTCTGGTGGTCTCTGCTTGCATCCCCAACTTAGCTGTCCC
CTGACCCAGAGCCTAGGGGATCCGGGGCTTGTACAGAAGAGACAGTCCAAGGGGACTGGATCCCAGCAGTGATGTTGGTTGAGGCAGCAA
ACAGATGGCAGGATGGGCACTGCCGAGAACAGCATTGGTCCCAGAGCCCTGGGCATCAGACCTTAACCACCAGGCCCACAGCCCAGCGAG
GGAGAGGTCGTGAGGCCAGCTCCCGGGGCCCCTGTAACCCTACTCTCCTCTCTCCCTGGACCTCAGAGGTGACACCCATTGGGCCCTTCC
GGCATGCCCCCAGTTACTGTAAATGTGGCCCCCAGTGGGCATGGAGCCAGTGCCTGTGGTTGTTTCTCCAGAGTCAAAAGGGAAGTCGAG
GGATGGGGCGTCGTCAGCTGGCACTGTCTCTGCTGCAGCGGCCACACTGTACTCTGCACTGGTGTGAGGGCCCCTGCCTGGACTGTGGGA
CCCTCCTGGTGCTGCCCACCTTCCCTGTCCTGTAGCCCCCTCGGTGGGCCCAGGGCCTAGGGCCCAGGATCAAGTCACTCATCTCAGAAT
GTCCCCACCAATCCCCGCCACAGCAGGCGCCTCGGGTCCCAGATGTCTGCAGCCCTCAGCAGCTGCAGACCGCCCCTCACCAACCCAGAG
AACCTGCTTTACTTTGCCCAGGGACTTCCTCCCCATGTGAACATGGGGAACTTCGGGCCCTGCCTGGAGTCCTTGACCGCTCTCTGTGGG
CCCCACCCACTCTGTCCTGGGAAATGAAGAAGCATCTTCCTTAGGTCTGCCCTGCTTGCAAATCCACTAGCACCGACCCCACCACCTGGT
TCCGGCTCTGCACGCTTTGGGGTGTGGATGTCGAGAGGCACCACGGCCTCACCCAGGCATCTGCTTTACTCTGGACCATAGGAAACAAGA
CCGTTTGGAGGTTTCATCAGGATTTTGGGTTTTTCACATTTCACGCTAAGGAGTAGTGGCCCTGACTTCCGGTCGGCTGGCCAGCTGACT
CCCTAGGGCCTTCAGACGTGTATGCAAATGAGTGATGGATAAGGATGAGTCTTGGAGTTGCGGGCAGCCTGGAGACTCGTGGACTTACCG
CCTGGAGGCAGGCCCGGGAAGGCTGCTGTTTACTCATCGGGCAGCCACGTGCTCTCTGGAGGAAGTGATAGTTTCTGAAACCGCTCAGAT
GTTTTGGGGAAAGTTGGAGAAGCCGTGGCCTTGCGAGAGGTGGTTACACCAGAACCTGGACATTGGCCAGAAGAAGCTTAAGTGGGCAGA
CACTGTTTGCCCAGTGTTTGTGCAAGGATGGAGTGGGTGTCTCTGCATCACCCACAGCCGCAGCTGTAAGGCACGCTGGAAGGCACACGC
CTGCCAGGCAGGGCAGTCTGGCGCCCATGATGGGAGGGATTGACATGTTTCAACAAAATAATGCACTTCCTTACCTAGTGGCCCTTCACA

>73431_73431_1_RELB-TNFRSF8_RELB_chr19_45504943_ENST00000221452_TNFRSF8_chr1_12175634_ENST00000263932_length(amino acids)=366AA_BP=23
MLRSGPASGPSVPTGRAMPSRRVARPPAAPELGALDDLVEKTPCAWNSSRTCECRPGMICATSATNSRARCVPYPICAAETVTKPQDMAE
KDTTFEAPPLGTQPDCNPTPENGEAPASTSPTQSLLVDSQASKTLPIPTSAPVALSSTGKPVLDAGPVLFWVILVLVVVVGSSAFLLCHR
RACRKRIRQKLHLCYPVQTSQPKLELVDSRPRRSSTQLRSGASVTEPVAEERGLMSQPLMETCHSVGAAYLESLPLQDASPAGGPSSPRD
LPEPRVSTEHTNNKIEKIYIMKADTVIVGTVKAELPEGRGLAGPAEPELEEELEADHTPHYPEQETEPPLGSCSDVMLSVEEEGKEDPLP

--------------------------------------------------------------
>73431_73431_2_RELB-TNFRSF8_RELB_chr19_45504943_ENST00000221452_TNFRSF8_chr1_12175634_ENST00000417814_length(transcript)=1834nt_BP=256nt
CCCGCCGCCCGCCCGGCCCGGCCCCGCGCCCCGCGCAGCCCCGGGCGCCGCGCGTCCTGCCCGGCCTGCGGCCCCAGCCCTTGCGCCGCT
CGTCCGACCCGCGATCGTCCACCAGACCGTGCCTCCCGGCCGCCCGGCCGGCCCGCGTGCATGCTTCGGTCTGGGCCAGCCTCTGGGCCG
TCCGTCCCCACTGGCCGGGCCATGCCGAGTCGCCGCGTCGCCAGACCGCCGGCTGCGCCGGAGCTGGGGGCCTTAGATGACCTTGTGGAG
AAGACGCCATGTGCATGGAACTCCTCCCGCACCTGCGAATGTCGACCTGGCATGATCTGTGCCACATCAGCCACCAACTCCCGTGCCCGC
TGTGTCCCCTACCCAATCTGTGCAGCAGAGACGGTCACCAAGCCCCAGGATATGGCTGAGAAGGACACCACCTTTGAGGCGCCACCCCTG
GGGACCCAGCCGGACTGCAACCCCACCCCAGAGAATGGCGAGGCGCCTGCCAGCACCAGCCCCACTCAGAGCTTGCTGGTGGACTCCCAG
GCCAGTAAGACGCTGCCCATCCCAACCAGCGCTCCCGTCGCTCTCTCCTCCACGGGGAAGCCCGTTCTGGATGCAGGGCCAGTGCTCTTC
TGGGTGATCCTGGTGTTGGTTGTGGTGGTCGGCTCCAGCGCCTTCCTCCTGTGCCACCGGAGGGCCTGCAGGAAGCGAATTCGGCAGAAG
CTCCACCTGTGCTACCCGGTCCAGACCTCCCAGCCCAAGCTAGAGCTTGTGGATTCCAGACCCAGGAGGAGCTCAACGCTGAGGAGTGGT
GCGTCGGTGACAGAACCCGTCGCGGAAGAGCGAGGGTTAATGAGCCAGCCACTGATGGAGACCTGCCACAGCGTGGGGGCAGCCTACCTG
GAGAGCCTGCCGCTGCAGGATGCCAGCCCGGCCGGGGGCCCCTCGTCCCCCAGGGACCTTCCTGAGCCCCGGGTGTCCACGGAGCACACC
AATAACAAGATTGAGAAAATCTACATCATGAAGGCTGACACCGTGATCGTGGGGACCGTGAAGGCTGAGCTGCCGGAGGGCCGGGGCCTG
GCGGGGCCAGCAGAGCCCGAGTTGGAGGAGGAGCTGGAGGCGGACCATACCCCCCACTACCCCGAGCAGGAGACAGAACCGCCTCTGGGC
AGCTGCAGCGATGTCATGCTCTCAGTGGAAGAGGAAGGGAAAGAAGACCCCTTGCCCACAGCTGCCTCTGGAAAGTGAGGCCTGGGCTGG
GCTGGGGCTAGGAGGGCAGCAGGGTGGCCTCTGGGAGGCCAGGATGGCACTGTTGGCACCGAGGTTGGGGGCAGAGGCCCATCTGGCCTG
AACTGAGGCTCCAGCATCTAGTGGTGGACCGGCCGGTCACTGCAGGGGTCTGGTGGTCTCTGCTTGCATCCCCAACTTAGCTGTCCCCTG
ACCCAGAGCCTAGGGGATCCGGGGCTTGTACAGAAGAGACAGTCCAAGGGGACTGGATCCCAGCAGTGATGTTGGTTGAGGCAGCAAACA
GATGGCAGGATGGGCACTGCCGAGAACAGCATTGGTCCCAGAGCCCTGGGCATCAGACCTTAACCACCAGGCCCACAGCCCAGCGAGGGA
GAGGTCGTGAGGCCAGCTCCCGGGGCCCCTGTAACCCTACTCTCCTCTCTCCCTGGACCTCAGAGGTGACACCCATTGGGCCCTTCCGGC
ATGCCCCCAGTTACTGTAAATGTGGCCCCCAGTGGGCATGGAGCCAGTGCCTGTGGTTGTTTCTCCAGAGTCAAAAGGGAAGTCGAGGGA

>73431_73431_2_RELB-TNFRSF8_RELB_chr19_45504943_ENST00000221452_TNFRSF8_chr1_12175634_ENST00000417814_length(amino acids)=365AA_BP=23
MLRSGPASGPSVPTGRAMPSRRVARPPAAPELGALDDLVEKTPCAWNSSRTCECRPGMICATSATNSRARCVPYPICAAETVTKPQDMAE
KDTTFEAPPLGTQPDCNPTPENGEAPASTSPTQSLLVDSQASKTLPIPTSAPVALSSTGKPVLDAGPVLFWVILVLVVVVGSSAFLLCHR
RACRKRIRQKLHLCYPVQTSQPKLELVDSRPRRSSTLRSGASVTEPVAEERGLMSQPLMETCHSVGAAYLESLPLQDASPAGGPSSPRDL
PEPRVSTEHTNNKIEKIYIMKADTVIVGTVKAELPEGRGLAGPAEPELEEELEADHTPHYPEQETEPPLGSCSDVMLSVEEEGKEDPLPT

--------------------------------------------------------------
>73431_73431_3_RELB-TNFRSF8_RELB_chr19_45504943_ENST00000505236_TNFRSF8_chr1_12175634_ENST00000263932_length(transcript)=2896nt_BP=225nt
CGCGCAGCCCCGGGCGCCGCGCGTCCTGCCCGGCCTGCGGCCCCAGCCCTTGCGCCGCTCGTCCGACCCGCGATCGTCCACCAGACCGTG
CCTCCCGGCCGCCCGGCCGGCCCGCGTGCATGCTTCGGTCTGGGCCAGCCTCTGGGCCGTCCGTCCCCACTGGCCGGGCCATGCCGAGTC
GCCGCGTCGCCAGACCGCCGGCTGCGCCGGAGCTGGGGGCCTTAGATGACCTTGTGGAGAAGACGCCATGTGCATGGAACTCCTCCCGCA
CCTGCGAATGTCGACCTGGCATGATCTGTGCCACATCAGCCACCAACTCCCGTGCCCGCTGTGTCCCCTACCCAATCTGTGCAGCAGAGA
CGGTCACCAAGCCCCAGGATATGGCTGAGAAGGACACCACCTTTGAGGCGCCACCCCTGGGGACCCAGCCGGACTGCAACCCCACCCCAG
AGAATGGCGAGGCGCCTGCCAGCACCAGCCCCACTCAGAGCTTGCTGGTGGACTCCCAGGCCAGTAAGACGCTGCCCATCCCAACCAGCG
CTCCCGTCGCTCTCTCCTCCACGGGGAAGCCCGTTCTGGATGCAGGGCCAGTGCTCTTCTGGGTGATCCTGGTGTTGGTTGTGGTGGTCG
GCTCCAGCGCCTTCCTCCTGTGCCACCGGAGGGCCTGCAGGAAGCGAATTCGGCAGAAGCTCCACCTGTGCTACCCGGTCCAGACCTCCC
AGCCCAAGCTAGAGCTTGTGGATTCCAGACCCAGGAGGAGCTCAACGCAGCTGAGGAGTGGTGCGTCGGTGACAGAACCCGTCGCGGAAG
AGCGAGGGTTAATGAGCCAGCCACTGATGGAGACCTGCCACAGCGTGGGGGCAGCCTACCTGGAGAGCCTGCCGCTGCAGGATGCCAGCC
CGGCCGGGGGCCCCTCGTCCCCCAGGGACCTTCCTGAGCCCCGGGTGTCCACGGAGCACACCAATAACAAGATTGAGAAAATCTACATCA
TGAAGGCTGACACCGTGATCGTGGGGACCGTGAAGGCTGAGCTGCCGGAGGGCCGGGGCCTGGCGGGGCCAGCAGAGCCCGAGTTGGAGG
AGGAGCTGGAGGCGGACCATACCCCCCACTACCCCGAGCAGGAGACAGAACCGCCTCTGGGCAGCTGCAGCGATGTCATGCTCTCAGTGG
AAGAGGAAGGGAAAGAAGACCCCTTGCCCACAGCTGCCTCTGGAAAGTGAGGCCTGGGCTGGGCTGGGGCTAGGAGGGCAGCAGGGTGGC
CTCTGGGAGGCCAGGATGGCACTGTTGGCACCGAGGTTGGGGGCAGAGGCCCATCTGGCCTGAACTGAGGCTCCAGCATCTAGTGGTGGA
CCGGCCGGTCACTGCAGGGGTCTGGTGGTCTCTGCTTGCATCCCCAACTTAGCTGTCCCCTGACCCAGAGCCTAGGGGATCCGGGGCTTG
TACAGAAGAGACAGTCCAAGGGGACTGGATCCCAGCAGTGATGTTGGTTGAGGCAGCAAACAGATGGCAGGATGGGCACTGCCGAGAACA
GCATTGGTCCCAGAGCCCTGGGCATCAGACCTTAACCACCAGGCCCACAGCCCAGCGAGGGAGAGGTCGTGAGGCCAGCTCCCGGGGCCC
CTGTAACCCTACTCTCCTCTCTCCCTGGACCTCAGAGGTGACACCCATTGGGCCCTTCCGGCATGCCCCCAGTTACTGTAAATGTGGCCC
CCAGTGGGCATGGAGCCAGTGCCTGTGGTTGTTTCTCCAGAGTCAAAAGGGAAGTCGAGGGATGGGGCGTCGTCAGCTGGCACTGTCTCT
GCTGCAGCGGCCACACTGTACTCTGCACTGGTGTGAGGGCCCCTGCCTGGACTGTGGGACCCTCCTGGTGCTGCCCACCTTCCCTGTCCT
GTAGCCCCCTCGGTGGGCCCAGGGCCTAGGGCCCAGGATCAAGTCACTCATCTCAGAATGTCCCCACCAATCCCCGCCACAGCAGGCGCC
TCGGGTCCCAGATGTCTGCAGCCCTCAGCAGCTGCAGACCGCCCCTCACCAACCCAGAGAACCTGCTTTACTTTGCCCAGGGACTTCCTC
CCCATGTGAACATGGGGAACTTCGGGCCCTGCCTGGAGTCCTTGACCGCTCTCTGTGGGCCCCACCCACTCTGTCCTGGGAAATGAAGAA
GCATCTTCCTTAGGTCTGCCCTGCTTGCAAATCCACTAGCACCGACCCCACCACCTGGTTCCGGCTCTGCACGCTTTGGGGTGTGGATGT
CGAGAGGCACCACGGCCTCACCCAGGCATCTGCTTTACTCTGGACCATAGGAAACAAGACCGTTTGGAGGTTTCATCAGGATTTTGGGTT
TTTCACATTTCACGCTAAGGAGTAGTGGCCCTGACTTCCGGTCGGCTGGCCAGCTGACTCCCTAGGGCCTTCAGACGTGTATGCAAATGA
GTGATGGATAAGGATGAGTCTTGGAGTTGCGGGCAGCCTGGAGACTCGTGGACTTACCGCCTGGAGGCAGGCCCGGGAAGGCTGCTGTTT
ACTCATCGGGCAGCCACGTGCTCTCTGGAGGAAGTGATAGTTTCTGAAACCGCTCAGATGTTTTGGGGAAAGTTGGAGAAGCCGTGGCCT
TGCGAGAGGTGGTTACACCAGAACCTGGACATTGGCCAGAAGAAGCTTAAGTGGGCAGACACTGTTTGCCCAGTGTTTGTGCAAGGATGG
AGTGGGTGTCTCTGCATCACCCACAGCCGCAGCTGTAAGGCACGCTGGAAGGCACACGCCTGCCAGGCAGGGCAGTCTGGCGCCCATGAT
GGGAGGGATTGACATGTTTCAACAAAATAATGCACTTCCTTACCTAGTGGCCCTTCACACAACTTTTGAATCTCTAAAAATCCATAAAAT

>73431_73431_3_RELB-TNFRSF8_RELB_chr19_45504943_ENST00000505236_TNFRSF8_chr1_12175634_ENST00000263932_length(amino acids)=366AA_BP=23
MLRSGPASGPSVPTGRAMPSRRVARPPAAPELGALDDLVEKTPCAWNSSRTCECRPGMICATSATNSRARCVPYPICAAETVTKPQDMAE
KDTTFEAPPLGTQPDCNPTPENGEAPASTSPTQSLLVDSQASKTLPIPTSAPVALSSTGKPVLDAGPVLFWVILVLVVVVGSSAFLLCHR
RACRKRIRQKLHLCYPVQTSQPKLELVDSRPRRSSTQLRSGASVTEPVAEERGLMSQPLMETCHSVGAAYLESLPLQDASPAGGPSSPRD
LPEPRVSTEHTNNKIEKIYIMKADTVIVGTVKAELPEGRGLAGPAEPELEEELEADHTPHYPEQETEPPLGSCSDVMLSVEEEGKEDPLP

--------------------------------------------------------------
>73431_73431_4_RELB-TNFRSF8_RELB_chr19_45504943_ENST00000505236_TNFRSF8_chr1_12175634_ENST00000417814_length(transcript)=1803nt_BP=225nt
CGCGCAGCCCCGGGCGCCGCGCGTCCTGCCCGGCCTGCGGCCCCAGCCCTTGCGCCGCTCGTCCGACCCGCGATCGTCCACCAGACCGTG
CCTCCCGGCCGCCCGGCCGGCCCGCGTGCATGCTTCGGTCTGGGCCAGCCTCTGGGCCGTCCGTCCCCACTGGCCGGGCCATGCCGAGTC
GCCGCGTCGCCAGACCGCCGGCTGCGCCGGAGCTGGGGGCCTTAGATGACCTTGTGGAGAAGACGCCATGTGCATGGAACTCCTCCCGCA
CCTGCGAATGTCGACCTGGCATGATCTGTGCCACATCAGCCACCAACTCCCGTGCCCGCTGTGTCCCCTACCCAATCTGTGCAGCAGAGA
CGGTCACCAAGCCCCAGGATATGGCTGAGAAGGACACCACCTTTGAGGCGCCACCCCTGGGGACCCAGCCGGACTGCAACCCCACCCCAG
AGAATGGCGAGGCGCCTGCCAGCACCAGCCCCACTCAGAGCTTGCTGGTGGACTCCCAGGCCAGTAAGACGCTGCCCATCCCAACCAGCG
CTCCCGTCGCTCTCTCCTCCACGGGGAAGCCCGTTCTGGATGCAGGGCCAGTGCTCTTCTGGGTGATCCTGGTGTTGGTTGTGGTGGTCG
GCTCCAGCGCCTTCCTCCTGTGCCACCGGAGGGCCTGCAGGAAGCGAATTCGGCAGAAGCTCCACCTGTGCTACCCGGTCCAGACCTCCC
AGCCCAAGCTAGAGCTTGTGGATTCCAGACCCAGGAGGAGCTCAACGCTGAGGAGTGGTGCGTCGGTGACAGAACCCGTCGCGGAAGAGC
GAGGGTTAATGAGCCAGCCACTGATGGAGACCTGCCACAGCGTGGGGGCAGCCTACCTGGAGAGCCTGCCGCTGCAGGATGCCAGCCCGG
CCGGGGGCCCCTCGTCCCCCAGGGACCTTCCTGAGCCCCGGGTGTCCACGGAGCACACCAATAACAAGATTGAGAAAATCTACATCATGA
AGGCTGACACCGTGATCGTGGGGACCGTGAAGGCTGAGCTGCCGGAGGGCCGGGGCCTGGCGGGGCCAGCAGAGCCCGAGTTGGAGGAGG
AGCTGGAGGCGGACCATACCCCCCACTACCCCGAGCAGGAGACAGAACCGCCTCTGGGCAGCTGCAGCGATGTCATGCTCTCAGTGGAAG
AGGAAGGGAAAGAAGACCCCTTGCCCACAGCTGCCTCTGGAAAGTGAGGCCTGGGCTGGGCTGGGGCTAGGAGGGCAGCAGGGTGGCCTC
TGGGAGGCCAGGATGGCACTGTTGGCACCGAGGTTGGGGGCAGAGGCCCATCTGGCCTGAACTGAGGCTCCAGCATCTAGTGGTGGACCG
GCCGGTCACTGCAGGGGTCTGGTGGTCTCTGCTTGCATCCCCAACTTAGCTGTCCCCTGACCCAGAGCCTAGGGGATCCGGGGCTTGTAC
AGAAGAGACAGTCCAAGGGGACTGGATCCCAGCAGTGATGTTGGTTGAGGCAGCAAACAGATGGCAGGATGGGCACTGCCGAGAACAGCA
TTGGTCCCAGAGCCCTGGGCATCAGACCTTAACCACCAGGCCCACAGCCCAGCGAGGGAGAGGTCGTGAGGCCAGCTCCCGGGGCCCCTG
TAACCCTACTCTCCTCTCTCCCTGGACCTCAGAGGTGACACCCATTGGGCCCTTCCGGCATGCCCCCAGTTACTGTAAATGTGGCCCCCA
GTGGGCATGGAGCCAGTGCCTGTGGTTGTTTCTCCAGAGTCAAAAGGGAAGTCGAGGGATGGGGCGTCGTCAGCTGGCACTGTCTCTGCT

>73431_73431_4_RELB-TNFRSF8_RELB_chr19_45504943_ENST00000505236_TNFRSF8_chr1_12175634_ENST00000417814_length(amino acids)=365AA_BP=23
MLRSGPASGPSVPTGRAMPSRRVARPPAAPELGALDDLVEKTPCAWNSSRTCECRPGMICATSATNSRARCVPYPICAAETVTKPQDMAE
KDTTFEAPPLGTQPDCNPTPENGEAPASTSPTQSLLVDSQASKTLPIPTSAPVALSSTGKPVLDAGPVLFWVILVLVVVVGSSAFLLCHR
RACRKRIRQKLHLCYPVQTSQPKLELVDSRPRRSSTLRSGASVTEPVAEERGLMSQPLMETCHSVGAAYLESLPLQDASPAGGPSSPRDL
PEPRVSTEHTNNKIEKIYIMKADTVIVGTVKAELPEGRGLAGPAEPELEEELEADHTPHYPEQETEPPLGSCSDVMLSVEEEGKEDPLPT

--------------------------------------------------------------
>73431_73431_5_RELB-TNFRSF8_RELB_chr19_45504943_ENST00000540120_TNFRSF8_chr1_12175634_ENST00000263932_length(transcript)=2903nt_BP=232nt
CGCGCCCCGCGCAGCCCCGGGCGCCGCGCGTCCTGCCCGGCCTGCGGCCCCAGCCCTTGCGCCGCTCGTCCGACCCGCGATCGTCCACCA
GACCGTGCCTCCCGGCCGCCCGGCCGGCCCGCGTGCATGCTTCGGTCTGGGCCAGCCTCTGGGCCGTCCGTCCCCACTGGCCGGGCCATG
CCGAGTCGCCGCGTCGCCAGACCGCCGGCTGCGCCGGAGCTGGGGGCCTTAGATGACCTTGTGGAGAAGACGCCATGTGCATGGAACTCC
TCCCGCACCTGCGAATGTCGACCTGGCATGATCTGTGCCACATCAGCCACCAACTCCCGTGCCCGCTGTGTCCCCTACCCAATCTGTGCA
GCAGAGACGGTCACCAAGCCCCAGGATATGGCTGAGAAGGACACCACCTTTGAGGCGCCACCCCTGGGGACCCAGCCGGACTGCAACCCC
ACCCCAGAGAATGGCGAGGCGCCTGCCAGCACCAGCCCCACTCAGAGCTTGCTGGTGGACTCCCAGGCCAGTAAGACGCTGCCCATCCCA
ACCAGCGCTCCCGTCGCTCTCTCCTCCACGGGGAAGCCCGTTCTGGATGCAGGGCCAGTGCTCTTCTGGGTGATCCTGGTGTTGGTTGTG
GTGGTCGGCTCCAGCGCCTTCCTCCTGTGCCACCGGAGGGCCTGCAGGAAGCGAATTCGGCAGAAGCTCCACCTGTGCTACCCGGTCCAG
ACCTCCCAGCCCAAGCTAGAGCTTGTGGATTCCAGACCCAGGAGGAGCTCAACGCAGCTGAGGAGTGGTGCGTCGGTGACAGAACCCGTC
GCGGAAGAGCGAGGGTTAATGAGCCAGCCACTGATGGAGACCTGCCACAGCGTGGGGGCAGCCTACCTGGAGAGCCTGCCGCTGCAGGAT
GCCAGCCCGGCCGGGGGCCCCTCGTCCCCCAGGGACCTTCCTGAGCCCCGGGTGTCCACGGAGCACACCAATAACAAGATTGAGAAAATC
TACATCATGAAGGCTGACACCGTGATCGTGGGGACCGTGAAGGCTGAGCTGCCGGAGGGCCGGGGCCTGGCGGGGCCAGCAGAGCCCGAG
TTGGAGGAGGAGCTGGAGGCGGACCATACCCCCCACTACCCCGAGCAGGAGACAGAACCGCCTCTGGGCAGCTGCAGCGATGTCATGCTC
TCAGTGGAAGAGGAAGGGAAAGAAGACCCCTTGCCCACAGCTGCCTCTGGAAAGTGAGGCCTGGGCTGGGCTGGGGCTAGGAGGGCAGCA
GGGTGGCCTCTGGGAGGCCAGGATGGCACTGTTGGCACCGAGGTTGGGGGCAGAGGCCCATCTGGCCTGAACTGAGGCTCCAGCATCTAG
TGGTGGACCGGCCGGTCACTGCAGGGGTCTGGTGGTCTCTGCTTGCATCCCCAACTTAGCTGTCCCCTGACCCAGAGCCTAGGGGATCCG
GGGCTTGTACAGAAGAGACAGTCCAAGGGGACTGGATCCCAGCAGTGATGTTGGTTGAGGCAGCAAACAGATGGCAGGATGGGCACTGCC
GAGAACAGCATTGGTCCCAGAGCCCTGGGCATCAGACCTTAACCACCAGGCCCACAGCCCAGCGAGGGAGAGGTCGTGAGGCCAGCTCCC
GGGGCCCCTGTAACCCTACTCTCCTCTCTCCCTGGACCTCAGAGGTGACACCCATTGGGCCCTTCCGGCATGCCCCCAGTTACTGTAAAT
GTGGCCCCCAGTGGGCATGGAGCCAGTGCCTGTGGTTGTTTCTCCAGAGTCAAAAGGGAAGTCGAGGGATGGGGCGTCGTCAGCTGGCAC
TGTCTCTGCTGCAGCGGCCACACTGTACTCTGCACTGGTGTGAGGGCCCCTGCCTGGACTGTGGGACCCTCCTGGTGCTGCCCACCTTCC
CTGTCCTGTAGCCCCCTCGGTGGGCCCAGGGCCTAGGGCCCAGGATCAAGTCACTCATCTCAGAATGTCCCCACCAATCCCCGCCACAGC
AGGCGCCTCGGGTCCCAGATGTCTGCAGCCCTCAGCAGCTGCAGACCGCCCCTCACCAACCCAGAGAACCTGCTTTACTTTGCCCAGGGA
CTTCCTCCCCATGTGAACATGGGGAACTTCGGGCCCTGCCTGGAGTCCTTGACCGCTCTCTGTGGGCCCCACCCACTCTGTCCTGGGAAA
TGAAGAAGCATCTTCCTTAGGTCTGCCCTGCTTGCAAATCCACTAGCACCGACCCCACCACCTGGTTCCGGCTCTGCACGCTTTGGGGTG
TGGATGTCGAGAGGCACCACGGCCTCACCCAGGCATCTGCTTTACTCTGGACCATAGGAAACAAGACCGTTTGGAGGTTTCATCAGGATT
TTGGGTTTTTCACATTTCACGCTAAGGAGTAGTGGCCCTGACTTCCGGTCGGCTGGCCAGCTGACTCCCTAGGGCCTTCAGACGTGTATG
CAAATGAGTGATGGATAAGGATGAGTCTTGGAGTTGCGGGCAGCCTGGAGACTCGTGGACTTACCGCCTGGAGGCAGGCCCGGGAAGGCT
GCTGTTTACTCATCGGGCAGCCACGTGCTCTCTGGAGGAAGTGATAGTTTCTGAAACCGCTCAGATGTTTTGGGGAAAGTTGGAGAAGCC
GTGGCCTTGCGAGAGGTGGTTACACCAGAACCTGGACATTGGCCAGAAGAAGCTTAAGTGGGCAGACACTGTTTGCCCAGTGTTTGTGCA
AGGATGGAGTGGGTGTCTCTGCATCACCCACAGCCGCAGCTGTAAGGCACGCTGGAAGGCACACGCCTGCCAGGCAGGGCAGTCTGGCGC
CCATGATGGGAGGGATTGACATGTTTCAACAAAATAATGCACTTCCTTACCTAGTGGCCCTTCACACAACTTTTGAATCTCTAAAAATCC

>73431_73431_5_RELB-TNFRSF8_RELB_chr19_45504943_ENST00000540120_TNFRSF8_chr1_12175634_ENST00000263932_length(amino acids)=366AA_BP=23
MLRSGPASGPSVPTGRAMPSRRVARPPAAPELGALDDLVEKTPCAWNSSRTCECRPGMICATSATNSRARCVPYPICAAETVTKPQDMAE
KDTTFEAPPLGTQPDCNPTPENGEAPASTSPTQSLLVDSQASKTLPIPTSAPVALSSTGKPVLDAGPVLFWVILVLVVVVGSSAFLLCHR
RACRKRIRQKLHLCYPVQTSQPKLELVDSRPRRSSTQLRSGASVTEPVAEERGLMSQPLMETCHSVGAAYLESLPLQDASPAGGPSSPRD
LPEPRVSTEHTNNKIEKIYIMKADTVIVGTVKAELPEGRGLAGPAEPELEEELEADHTPHYPEQETEPPLGSCSDVMLSVEEEGKEDPLP

--------------------------------------------------------------
>73431_73431_6_RELB-TNFRSF8_RELB_chr19_45504943_ENST00000540120_TNFRSF8_chr1_12175634_ENST00000417814_length(transcript)=1810nt_BP=232nt
CGCGCCCCGCGCAGCCCCGGGCGCCGCGCGTCCTGCCCGGCCTGCGGCCCCAGCCCTTGCGCCGCTCGTCCGACCCGCGATCGTCCACCA
GACCGTGCCTCCCGGCCGCCCGGCCGGCCCGCGTGCATGCTTCGGTCTGGGCCAGCCTCTGGGCCGTCCGTCCCCACTGGCCGGGCCATG
CCGAGTCGCCGCGTCGCCAGACCGCCGGCTGCGCCGGAGCTGGGGGCCTTAGATGACCTTGTGGAGAAGACGCCATGTGCATGGAACTCC
TCCCGCACCTGCGAATGTCGACCTGGCATGATCTGTGCCACATCAGCCACCAACTCCCGTGCCCGCTGTGTCCCCTACCCAATCTGTGCA
GCAGAGACGGTCACCAAGCCCCAGGATATGGCTGAGAAGGACACCACCTTTGAGGCGCCACCCCTGGGGACCCAGCCGGACTGCAACCCC
ACCCCAGAGAATGGCGAGGCGCCTGCCAGCACCAGCCCCACTCAGAGCTTGCTGGTGGACTCCCAGGCCAGTAAGACGCTGCCCATCCCA
ACCAGCGCTCCCGTCGCTCTCTCCTCCACGGGGAAGCCCGTTCTGGATGCAGGGCCAGTGCTCTTCTGGGTGATCCTGGTGTTGGTTGTG
GTGGTCGGCTCCAGCGCCTTCCTCCTGTGCCACCGGAGGGCCTGCAGGAAGCGAATTCGGCAGAAGCTCCACCTGTGCTACCCGGTCCAG
ACCTCCCAGCCCAAGCTAGAGCTTGTGGATTCCAGACCCAGGAGGAGCTCAACGCTGAGGAGTGGTGCGTCGGTGACAGAACCCGTCGCG
GAAGAGCGAGGGTTAATGAGCCAGCCACTGATGGAGACCTGCCACAGCGTGGGGGCAGCCTACCTGGAGAGCCTGCCGCTGCAGGATGCC
AGCCCGGCCGGGGGCCCCTCGTCCCCCAGGGACCTTCCTGAGCCCCGGGTGTCCACGGAGCACACCAATAACAAGATTGAGAAAATCTAC
ATCATGAAGGCTGACACCGTGATCGTGGGGACCGTGAAGGCTGAGCTGCCGGAGGGCCGGGGCCTGGCGGGGCCAGCAGAGCCCGAGTTG
GAGGAGGAGCTGGAGGCGGACCATACCCCCCACTACCCCGAGCAGGAGACAGAACCGCCTCTGGGCAGCTGCAGCGATGTCATGCTCTCA
GTGGAAGAGGAAGGGAAAGAAGACCCCTTGCCCACAGCTGCCTCTGGAAAGTGAGGCCTGGGCTGGGCTGGGGCTAGGAGGGCAGCAGGG
TGGCCTCTGGGAGGCCAGGATGGCACTGTTGGCACCGAGGTTGGGGGCAGAGGCCCATCTGGCCTGAACTGAGGCTCCAGCATCTAGTGG
TGGACCGGCCGGTCACTGCAGGGGTCTGGTGGTCTCTGCTTGCATCCCCAACTTAGCTGTCCCCTGACCCAGAGCCTAGGGGATCCGGGG
CTTGTACAGAAGAGACAGTCCAAGGGGACTGGATCCCAGCAGTGATGTTGGTTGAGGCAGCAAACAGATGGCAGGATGGGCACTGCCGAG
AACAGCATTGGTCCCAGAGCCCTGGGCATCAGACCTTAACCACCAGGCCCACAGCCCAGCGAGGGAGAGGTCGTGAGGCCAGCTCCCGGG
GCCCCTGTAACCCTACTCTCCTCTCTCCCTGGACCTCAGAGGTGACACCCATTGGGCCCTTCCGGCATGCCCCCAGTTACTGTAAATGTG
GCCCCCAGTGGGCATGGAGCCAGTGCCTGTGGTTGTTTCTCCAGAGTCAAAAGGGAAGTCGAGGGATGGGGCGTCGTCAGCTGGCACTGT

>73431_73431_6_RELB-TNFRSF8_RELB_chr19_45504943_ENST00000540120_TNFRSF8_chr1_12175634_ENST00000417814_length(amino acids)=365AA_BP=23
MLRSGPASGPSVPTGRAMPSRRVARPPAAPELGALDDLVEKTPCAWNSSRTCECRPGMICATSATNSRARCVPYPICAAETVTKPQDMAE
KDTTFEAPPLGTQPDCNPTPENGEAPASTSPTQSLLVDSQASKTLPIPTSAPVALSSTGKPVLDAGPVLFWVILVLVVVVGSSAFLLCHR
RACRKRIRQKLHLCYPVQTSQPKLELVDSRPRRSSTLRSGASVTEPVAEERGLMSQPLMETCHSVGAAYLESLPLQDASPAGGPSSPRDL
PEPRVSTEHTNNKIEKIYIMKADTVIVGTVKAELPEGRGLAGPAEPELEEELEADHTPHYPEQETEPPLGSCSDVMLSVEEEGKEDPLPT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RELB-TNFRSF8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RELB-TNFRSF8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RELB-TNFRSF8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource