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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:REPS2-GLRA2 (FusionGDB2 ID:73476)

Fusion Gene Summary for REPS2-GLRA2

check button Fusion gene summary
Fusion gene informationFusion gene name: REPS2-GLRA2
Fusion gene ID: 73476
HgeneTgene
Gene symbol

REPS2

GLRA2

Gene ID

9185

2742

Gene nameRALBP1 associated Eps domain containing 2glycine receptor alpha 2
SynonymsPOB1GLR
Cytomap

Xp22.2

Xp22.2

Type of geneprotein-codingprotein-coding
DescriptionralBP1-associated Eps domain-containing protein 2RALBP1-interacting protein 2partner of Ral-binding protein 1partner of RalBP1glycine receptor subunit alpha-2glycine receptor alpha 2 subunitglycine receptor, alpha-2 polypeptide
Modification date2020031320200313
UniProtAcc.

P23416

Ensembl transtripts involved in fusion geneENST00000469714, ENST00000303843, 
ENST00000357277, ENST00000380064, 
ENST00000218075, ENST00000355020, 
ENST00000443437, 
Fusion gene scores* DoF score13 X 9 X 10=11702 X 2 X 2=8
# samples 192
** MAII scorelog2(19/1170*10)=-2.62243720613982
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: REPS2 [Title/Abstract] AND GLRA2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointREPS2(17121902)-GLRA2(14708832), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGLRA2

GO:0007218

neuropeptide signaling pathway

2155780

TgeneGLRA2

GO:0034220

ion transmembrane transport

2155780

TgeneGLRA2

GO:0071230

cellular response to amino acid stimulus

2155780

TgeneGLRA2

GO:0071294

cellular response to zinc ion

23895467

TgeneGLRA2

GO:0071361

cellular response to ethanol

23895467

TgeneGLRA2

GO:1902476

chloride transmembrane transport

23895467


check buttonFusion gene breakpoints across REPS2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GLRA2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-X6-A8C6-01AREPS2chrX

17121902

-GLRA2chrX

14708832

+
ChimerDB4SARCTCGA-X6-A8C6-01AREPS2chrX

17121902

+GLRA2chrX

14708832

+


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Fusion Gene ORF analysis for REPS2-GLRA2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000469714ENST00000218075REPS2chrX

17121902

+GLRA2chrX

14708832

+
3UTR-3CDSENST00000469714ENST00000355020REPS2chrX

17121902

+GLRA2chrX

14708832

+
3UTR-3CDSENST00000469714ENST00000443437REPS2chrX

17121902

+GLRA2chrX

14708832

+
In-frameENST00000303843ENST00000218075REPS2chrX

17121902

+GLRA2chrX

14708832

+
In-frameENST00000303843ENST00000355020REPS2chrX

17121902

+GLRA2chrX

14708832

+
In-frameENST00000303843ENST00000443437REPS2chrX

17121902

+GLRA2chrX

14708832

+
In-frameENST00000357277ENST00000218075REPS2chrX

17121902

+GLRA2chrX

14708832

+
In-frameENST00000357277ENST00000355020REPS2chrX

17121902

+GLRA2chrX

14708832

+
In-frameENST00000357277ENST00000443437REPS2chrX

17121902

+GLRA2chrX

14708832

+
In-frameENST00000380064ENST00000218075REPS2chrX

17121902

+GLRA2chrX

14708832

+
In-frameENST00000380064ENST00000355020REPS2chrX

17121902

+GLRA2chrX

14708832

+
In-frameENST00000380064ENST00000443437REPS2chrX

17121902

+GLRA2chrX

14708832

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000357277REPS2chrX17121902+ENST00000443437GLRA2chrX14708832+350217491712177668
ENST00000357277REPS2chrX17121902+ENST00000218075GLRA2chrX14708832+350517491712177668
ENST00000357277REPS2chrX17121902+ENST00000355020GLRA2chrX14708832+226317491712177668
ENST00000303843REPS2chrX17121902+ENST00000443437GLRA2chrX14708832+3328157502003667
ENST00000303843REPS2chrX17121902+ENST00000218075GLRA2chrX14708832+3331157502003667
ENST00000303843REPS2chrX17121902+ENST00000355020GLRA2chrX14708832+2089157502003667
ENST00000380064REPS2chrX17121902+ENST00000443437GLRA2chrX14708832+29301177671605512
ENST00000380064REPS2chrX17121902+ENST00000218075GLRA2chrX14708832+29331177671605512
ENST00000380064REPS2chrX17121902+ENST00000355020GLRA2chrX14708832+16911177671605512

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000357277ENST00000443437REPS2chrX17121902+GLRA2chrX14708832+0.0004096090.99959046
ENST00000357277ENST00000218075REPS2chrX17121902+GLRA2chrX14708832+0.0004108760.99958915
ENST00000357277ENST00000355020REPS2chrX17121902+GLRA2chrX14708832+0.0044683740.99553156
ENST00000303843ENST00000443437REPS2chrX17121902+GLRA2chrX14708832+0.0002887940.9997112
ENST00000303843ENST00000218075REPS2chrX17121902+GLRA2chrX14708832+0.0002911140.99970883
ENST00000303843ENST00000355020REPS2chrX17121902+GLRA2chrX14708832+0.0033770460.9966229
ENST00000380064ENST00000443437REPS2chrX17121902+GLRA2chrX14708832+0.0004018250.9995982
ENST00000380064ENST00000218075REPS2chrX17121902+GLRA2chrX14708832+0.0004043330.9995957
ENST00000380064ENST00000355020REPS2chrX17121902+GLRA2chrX14708832+0.0034022120.9965978

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Fusion Genomic Features for REPS2-GLRA2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
REPS2chrX17121902+GLRA2chrX14708831+2.73E-101
REPS2chrX17121902+GLRA2chrX14708831+2.73E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for REPS2-GLRA2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:17121902/chrX:14708832)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GLRA2

P23416

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:2155780, PubMed:15302677, PubMed:16144831, PubMed:23895467, PubMed:25445488). Channel opening is also triggered by taurine and beta-alanine (PubMed:15302677). Plays a role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488). Plays a role in cellular responses to ethanol (PubMed:23895467). {ECO:0000269|PubMed:15302677, ECO:0000269|PubMed:16144831, ECO:0000269|PubMed:2155780, ECO:0000269|PubMed:23895467, ECO:0000269|PubMed:25445488}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneREPS2chrX:17121902chrX:14708832ENST00000303843+1418328_339525660.0Calcium bindingOntology_term=ECO:0000255
HgeneREPS2chrX:17121902chrX:14708832ENST00000357277+1418328_339526661.0Calcium bindingOntology_term=ECO:0000255
HgeneREPS2chrX:17121902chrX:14708832ENST00000303843+14183_76525660.0Compositional biasNote=Ala-rich
HgeneREPS2chrX:17121902chrX:14708832ENST00000303843+1418477_524525660.0Compositional biasNote=Pro-rich
HgeneREPS2chrX:17121902chrX:14708832ENST00000357277+14183_76526661.0Compositional biasNote=Ala-rich
HgeneREPS2chrX:17121902chrX:14708832ENST00000357277+1418477_524526661.0Compositional biasNote=Pro-rich
HgeneREPS2chrX:17121902chrX:14708832ENST00000303843+1418282_373525660.0DomainEH 2
HgeneREPS2chrX:17121902chrX:14708832ENST00000303843+1418315_350525660.0DomainEF-hand
HgeneREPS2chrX:17121902chrX:14708832ENST00000303843+141834_147525660.0DomainEH 1
HgeneREPS2chrX:17121902chrX:14708832ENST00000357277+1418282_373526661.0DomainEH 2
HgeneREPS2chrX:17121902chrX:14708832ENST00000357277+1418315_350526661.0DomainEF-hand
HgeneREPS2chrX:17121902chrX:14708832ENST00000357277+141834_147526661.0DomainEH 1
TgeneGLRA2chrX:17121902chrX:14708832ENST00000443437811236_241221364.0RegionStrychnine-binding
TgeneGLRA2chrX:17121902chrX:14708832ENST0000021807569337_420310453.0Topological domainCytoplasmic
TgeneGLRA2chrX:17121902chrX:14708832ENST0000021807569442_452310453.0Topological domainExtracellular
TgeneGLRA2chrX:17121902chrX:14708832ENST0000035502069337_420310453.0Topological domainCytoplasmic
TgeneGLRA2chrX:17121902chrX:14708832ENST0000035502069442_452310453.0Topological domainExtracellular
TgeneGLRA2chrX:17121902chrX:14708832ENST00000443437811279_283221364.0Topological domainCytoplasmic
TgeneGLRA2chrX:17121902chrX:14708832ENST00000443437811305_315221364.0Topological domainExtracellular
TgeneGLRA2chrX:17121902chrX:14708832ENST00000443437811337_420221364.0Topological domainCytoplasmic
TgeneGLRA2chrX:17121902chrX:14708832ENST00000443437811442_452221364.0Topological domainExtracellular
TgeneGLRA2chrX:17121902chrX:14708832ENST0000021807569316_336310453.0TransmembraneHelical%3B Name%3D3
TgeneGLRA2chrX:17121902chrX:14708832ENST0000021807569421_441310453.0TransmembraneHelical%3B Name%3D4
TgeneGLRA2chrX:17121902chrX:14708832ENST0000035502069316_336310453.0TransmembraneHelical%3B Name%3D3
TgeneGLRA2chrX:17121902chrX:14708832ENST0000035502069421_441310453.0TransmembraneHelical%3B Name%3D4
TgeneGLRA2chrX:17121902chrX:14708832ENST00000443437811257_278221364.0TransmembraneHelical%3B Name%3D1
TgeneGLRA2chrX:17121902chrX:14708832ENST00000443437811284_304221364.0TransmembraneHelical%3B Name%3D2
TgeneGLRA2chrX:17121902chrX:14708832ENST00000443437811316_336221364.0TransmembraneHelical%3B Name%3D3
TgeneGLRA2chrX:17121902chrX:14708832ENST00000443437811421_441221364.0TransmembraneHelical%3B Name%3D4

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneREPS2chrX:17121902chrX:14708832ENST00000303843+1418601_657525660.0Coiled coilOntology_term=ECO:0000255
HgeneREPS2chrX:17121902chrX:14708832ENST00000357277+1418601_657526661.0Coiled coilOntology_term=ECO:0000255
TgeneGLRA2chrX:17121902chrX:14708832ENST0000021807569236_241310453.0RegionStrychnine-binding
TgeneGLRA2chrX:17121902chrX:14708832ENST0000035502069236_241310453.0RegionStrychnine-binding
TgeneGLRA2chrX:17121902chrX:14708832ENST0000021807569279_283310453.0Topological domainCytoplasmic
TgeneGLRA2chrX:17121902chrX:14708832ENST000002180756928_256310453.0Topological domainExtracellular
TgeneGLRA2chrX:17121902chrX:14708832ENST0000021807569305_315310453.0Topological domainExtracellular
TgeneGLRA2chrX:17121902chrX:14708832ENST0000035502069279_283310453.0Topological domainCytoplasmic
TgeneGLRA2chrX:17121902chrX:14708832ENST000003550206928_256310453.0Topological domainExtracellular
TgeneGLRA2chrX:17121902chrX:14708832ENST0000035502069305_315310453.0Topological domainExtracellular
TgeneGLRA2chrX:17121902chrX:14708832ENST0000044343781128_256221364.0Topological domainExtracellular
TgeneGLRA2chrX:17121902chrX:14708832ENST0000021807569257_278310453.0TransmembraneHelical%3B Name%3D1
TgeneGLRA2chrX:17121902chrX:14708832ENST0000021807569284_304310453.0TransmembraneHelical%3B Name%3D2
TgeneGLRA2chrX:17121902chrX:14708832ENST0000035502069257_278310453.0TransmembraneHelical%3B Name%3D1
TgeneGLRA2chrX:17121902chrX:14708832ENST0000035502069284_304310453.0TransmembraneHelical%3B Name%3D2


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Fusion Gene Sequence for REPS2-GLRA2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>73476_73476_1_REPS2-GLRA2_REPS2_chrX_17121902_ENST00000303843_GLRA2_chrX_14708832_ENST00000218075_length(transcript)=3331nt_BP=1575nt
ATGGAGGCGGCAGCGGCGGCGGCGGCGGCGGCAGCGGCAGCGGCAGCGGCGGGCGGGGGCTGTGGCTCCGGGCCGCCGCCGCTGCTGCTG
AGCGAGGGCGAGCAGCAGTGCTACTCCGAGCTCTTCGCGCGCTGTGCCGGCGCCGCGGGCGGGGGCCCCGGGTCTGGGCCCCCCGAGGCC
GCCAGAGTCGCCCCCGGCACGGCCACTGCGGCCGCCGGCCCCGTGGCTGACCTGTTTCGGGCATCGCAGCTGCCCGCCGAGACGCTGCAC
CAGATCACAGAACTGTGTGGTGCAAAGCGGGTTGGTTATTTTGGTCCAACACAGTTTTACATTGCCCTGAAATTAATTGCTGCAGCACAA
TCTGGCCTCCCGGTACGGATAGAGAGTATTAAATGTGAATTGCCTCTGCCTCGCTTTATGATGTCAAAGAATGATGGTGAGATACGATTT
GGGAACCCAGCTGAGCTGCATGGAACTAAGGTTCAGATTCCATATTTAACTACAGAAAAAAATTCCTTCAAAAGAATGGACGATGAGGAT
AAACAGGAAACACAGTCTCCCACGATGTCACCCCTCGCCTCCCCTCCTTCTTCCCCGCCTCATTACCAGAGGGTGCCCTTGAGCCATGGC
TACAGCAAACTGCGGAGCAGCGCAGAACAGATGCATCCAGCACCTTATGAAGCTAGGCAGCCCCTTGTCCAGCCCGAGGGATCCTCATCA
GGGGGCCCAGGAACCAAGCCCCTTCGGCATCAGGCTTCCCTTATCCGGTCCTTTTCAGTGGAGAGGGAACTACAGGATAACAGCAGTTAC
CCCGACGAACCCTGGAGGATAACAGAAGAACAGCGCGAGTACTATGTCAATCAGTTCCGATCCCTTCAGCCAGACCCAAGCTCTTTCATT
TCAGGTTCTGTGGCCAAGAACTTCTTCACCAAATCAAAGCTTTCCATTCCAGAACTCTCCTATATATGGGAGCTTAGTGATGCTGACTGT
GATGGAGCCCTGACCCTGCCTGAGTTCTGTGCTGCGTTTCATCTCATTGTGGCTCGGAAGAACGGCTACCCATTGCCTGAGGGCCTCCCT
CCAACTCTGCAGCCAGAATACCTGCAGGCAGCTTTTCCTAAGCCCAAATGGGACTGTCAATTATTTGATTCTTATTCTGAGTCACTGCCG
GCAAATCAACAACCTCGTGACTTGAATCGGATGGAGAAGACATCTGTTAAAGACATGGCTGACCTTCCTGTCCCTAACCAGGATGTAACT
AGTGATGACAAACAAGCTTTGAAAAGTACTATCAATGAAGCCTTACCAAAGGACGTGTCTGAGGATCCAGCAACTCCCAAGGATTCCAAC
AGTCTCAAAGCAAGACCAAGATCCAGATCTTACTCTAGCACCTCCATAGAAGAGGCCATGAAAAGGGGCGAGGACCCTCCCACCCCGCCA
CCTCGGCCACAGAAAACCCATTCCAGAGCCTCCTCCTTGGATCTGAATAAAGTCTTCCAGCCCAGTGTGCCAGCTACCAAGTCAGGATTG
TTACCCCCACCACCTGCGCTCCCTCCAAGACCTTGTCCATCACAGGTCTCCTATGTAAAAGCGATTGACATCTGGATGGCGGTGTGCCTT
CTGTTTGTGTTTGCTGCCTTACTGGAATACGCAGCGGTGAACTTCGTCTCCAGGCAACACAAGGAGTTCCTGCGCCTCCGAAGAAGACAG
AAGAGGCAGAATAAGGAAGAAGACGTTACTCGTGAAAGTCGTTTTAATTTTAGCGGTTATGGGATGGGTCACTGCCTCCAAGTGAAAGAT
GGAACAGCTGTCAAGGCCACACCTGCCAACCCACTCCCACAACCGCCAAAAGATGGAGATGCTATCAAGAAGAAGTTTGTGGACCGGGCA
AAAAGGATTGACACGATATCTCGAGCTGCCTTCCCATTGGCCTTCCTCATTTTCAACATCTTTTACTGGATCACATACAAGATCATTCGG
CATGAAGATGTCCACAAGAAATAGATGTGCCCTACAGACCCTGGGACCTTCTTGCCTCAGTGTTGTGCTTGTAAATACACAGTGAAATTG
TCTTTATATCACTTTGACAGAGGAGAAGATTGAGGGAGGGGGGAGGGAGGGTCATGGGGGTGGGTTTCCTGGCACCTACATGAAAAAAAA
GACAAGTTATATGGGTGATGAAGAAAACTGCACAAAATTAAGGGGTTGCAGAATCACGGGAGCATAATAATTCCCTTCCATAATCTTTAG
CATTGTTCTTTCAGTCAGACATGATATGCGCAACATTCAGACATGATATGCGCATCATTCAGACATGATATGCGGGGTCAAGTTCTTAAG
GGCTGTTTGCCTTTTGGTCCTTTTGGTTTGGTTTGGCTTTGACTAATTCTGGTACTGAAAAGTTAGCTATACACACACACACACACACAC
ACACACACACACACACACACACACACACACACACACACAAACTTCAAAAATGCTTAACCATCTGACCATAGTGACTAGCCTATAGTGAGT
CGAGGACCAAACTTTTTCAGGAAAATGCTGCCTCGTTTTTAAAACAAGCCTCCTAAGCTATGTTCTTTACAATGTCTGTAATTAGTGTTT
CACTTGAGAAAGCCTTTTGTGGGTCGTAAATTATTTCTACTTATCCAGTAAATAACAATGACAAAATAAACACCAATGACAGAAAAATTT
CTACTTTACTGTCCATATAGGTGTGCATTTTAATATTTTTCTTTCCAAGATAAAATTTTGAAACTTAAATTGTGTATTGTGTAATTAATT
TGATAGTGTACCCTCTTAATAAATGCCCACTTTATTTTATATCCAAGTTAGTGCATTATATATATATTTTTGCTTTGGCTATATTTACAC
GTGACTTTAATCGCCCAACTGTGACTAGTCATTGCAGCTACTCAGCTACAGTATTTATGGAGATGGTGTGTCCTGAACAGTGTAGCTCAG
GTCAGCTTGAACTTTCCATTTCTGCTCTCATTGTAGGTGTAACTACTAGTCCTAATGTCAACTGACCCATGATTTCTACTGTCAGTCAAT
ATAAGTGAACATTGTTTTAAATATCCTTAACTAACTTAAAGAATTTTAAAATTGTACTGTGATTTTCATAACCCGTTGCCTTTTTGGTAC
CAGAGCTACGTGGTTTGAATTCTGGCTACATGTTTTAAGTAAGAAAAAAAAAGACGTATTTTTGCTTACTCAGATAAAAGACAACCTGTA
AAAATATAATAATTAAATTTTACATGTGCTGTACAAGGGGTTATTTTAAAAAGCATTTGTTCAATTTCAATAAAGCTAAGTGTGCCGCAA

>73476_73476_1_REPS2-GLRA2_REPS2_chrX_17121902_ENST00000303843_GLRA2_chrX_14708832_ENST00000218075_length(amino acids)=667AA_BP=523
MEAAAAAAAAAAAAAAAGGGCGSGPPPLLLSEGEQQCYSELFARCAGAAGGGPGSGPPEAARVAPGTATAAAGPVADLFRASQLPAETLH
QITELCGAKRVGYFGPTQFYIALKLIAAAQSGLPVRIESIKCELPLPRFMMSKNDGEIRFGNPAELHGTKVQIPYLTTEKNSFKRMDDED
KQETQSPTMSPLASPPSSPPHYQRVPLSHGYSKLRSSAEQMHPAPYEARQPLVQPEGSSSGGPGTKPLRHQASLIRSFSVERELQDNSSY
PDEPWRITEEQREYYVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIPELSYIWELSDADCDGALTLPEFCAAFHLIVARKNGYPLPEGLP
PTLQPEYLQAAFPKPKWDCQLFDSYSESLPANQQPRDLNRMEKTSVKDMADLPVPNQDVTSDDKQALKSTINEALPKDVSEDPATPKDSN
SLKARPRSRSYSSTSIEEAMKRGEDPPTPPPRPQKTHSRASSLDLNKVFQPSVPATKSGLLPPPPALPPRPCPSQVSYVKAIDIWMAVCL
LFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQNKEEDVTRESRFNFSGYGMGHCLQVKDGTAVKATPANPLPQPPKDGDAIKKKFVDRA

--------------------------------------------------------------
>73476_73476_2_REPS2-GLRA2_REPS2_chrX_17121902_ENST00000303843_GLRA2_chrX_14708832_ENST00000355020_length(transcript)=2089nt_BP=1575nt
ATGGAGGCGGCAGCGGCGGCGGCGGCGGCGGCAGCGGCAGCGGCAGCGGCGGGCGGGGGCTGTGGCTCCGGGCCGCCGCCGCTGCTGCTG
AGCGAGGGCGAGCAGCAGTGCTACTCCGAGCTCTTCGCGCGCTGTGCCGGCGCCGCGGGCGGGGGCCCCGGGTCTGGGCCCCCCGAGGCC
GCCAGAGTCGCCCCCGGCACGGCCACTGCGGCCGCCGGCCCCGTGGCTGACCTGTTTCGGGCATCGCAGCTGCCCGCCGAGACGCTGCAC
CAGATCACAGAACTGTGTGGTGCAAAGCGGGTTGGTTATTTTGGTCCAACACAGTTTTACATTGCCCTGAAATTAATTGCTGCAGCACAA
TCTGGCCTCCCGGTACGGATAGAGAGTATTAAATGTGAATTGCCTCTGCCTCGCTTTATGATGTCAAAGAATGATGGTGAGATACGATTT
GGGAACCCAGCTGAGCTGCATGGAACTAAGGTTCAGATTCCATATTTAACTACAGAAAAAAATTCCTTCAAAAGAATGGACGATGAGGAT
AAACAGGAAACACAGTCTCCCACGATGTCACCCCTCGCCTCCCCTCCTTCTTCCCCGCCTCATTACCAGAGGGTGCCCTTGAGCCATGGC
TACAGCAAACTGCGGAGCAGCGCAGAACAGATGCATCCAGCACCTTATGAAGCTAGGCAGCCCCTTGTCCAGCCCGAGGGATCCTCATCA
GGGGGCCCAGGAACCAAGCCCCTTCGGCATCAGGCTTCCCTTATCCGGTCCTTTTCAGTGGAGAGGGAACTACAGGATAACAGCAGTTAC
CCCGACGAACCCTGGAGGATAACAGAAGAACAGCGCGAGTACTATGTCAATCAGTTCCGATCCCTTCAGCCAGACCCAAGCTCTTTCATT
TCAGGTTCTGTGGCCAAGAACTTCTTCACCAAATCAAAGCTTTCCATTCCAGAACTCTCCTATATATGGGAGCTTAGTGATGCTGACTGT
GATGGAGCCCTGACCCTGCCTGAGTTCTGTGCTGCGTTTCATCTCATTGTGGCTCGGAAGAACGGCTACCCATTGCCTGAGGGCCTCCCT
CCAACTCTGCAGCCAGAATACCTGCAGGCAGCTTTTCCTAAGCCCAAATGGGACTGTCAATTATTTGATTCTTATTCTGAGTCACTGCCG
GCAAATCAACAACCTCGTGACTTGAATCGGATGGAGAAGACATCTGTTAAAGACATGGCTGACCTTCCTGTCCCTAACCAGGATGTAACT
AGTGATGACAAACAAGCTTTGAAAAGTACTATCAATGAAGCCTTACCAAAGGACGTGTCTGAGGATCCAGCAACTCCCAAGGATTCCAAC
AGTCTCAAAGCAAGACCAAGATCCAGATCTTACTCTAGCACCTCCATAGAAGAGGCCATGAAAAGGGGCGAGGACCCTCCCACCCCGCCA
CCTCGGCCACAGAAAACCCATTCCAGAGCCTCCTCCTTGGATCTGAATAAAGTCTTCCAGCCCAGTGTGCCAGCTACCAAGTCAGGATTG
TTACCCCCACCACCTGCGCTCCCTCCAAGACCTTGTCCATCACAGGTCTCCTATGTAAAAGCGATTGACATCTGGATGGCGGTGTGCCTT
CTGTTTGTGTTTGCTGCCTTACTGGAATACGCAGCGGTGAACTTCGTCTCCAGGCAACACAAGGAGTTCCTGCGCCTCCGAAGAAGACAG
AAGAGGCAGAATAAGGAAGAAGACGTTACTCGTGAAAGTCGTTTTAATTTTAGCGGTTATGGGATGGGTCACTGCCTCCAAGTGAAAGAT
GGAACAGCTGTCAAGGCCACACCTGCCAACCCACTCCCACAACCGCCAAAAGATGGAGATGCTATCAAGAAGAAGTTTGTGGACCGGGCA
AAAAGGATTGACACGATATCTCGAGCTGCCTTCCCATTGGCCTTCCTCATTTTCAACATCTTTTACTGGATCACATACAAGATCATTCGG
CATGAAGATGTCCACAAGAAATAGATGTGCCCTACAGACCCTGGGACCTTCTTGCCTCAGTGTTGTGCTTGTAAATACACAGTGAAATTG

>73476_73476_2_REPS2-GLRA2_REPS2_chrX_17121902_ENST00000303843_GLRA2_chrX_14708832_ENST00000355020_length(amino acids)=667AA_BP=523
MEAAAAAAAAAAAAAAAGGGCGSGPPPLLLSEGEQQCYSELFARCAGAAGGGPGSGPPEAARVAPGTATAAAGPVADLFRASQLPAETLH
QITELCGAKRVGYFGPTQFYIALKLIAAAQSGLPVRIESIKCELPLPRFMMSKNDGEIRFGNPAELHGTKVQIPYLTTEKNSFKRMDDED
KQETQSPTMSPLASPPSSPPHYQRVPLSHGYSKLRSSAEQMHPAPYEARQPLVQPEGSSSGGPGTKPLRHQASLIRSFSVERELQDNSSY
PDEPWRITEEQREYYVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIPELSYIWELSDADCDGALTLPEFCAAFHLIVARKNGYPLPEGLP
PTLQPEYLQAAFPKPKWDCQLFDSYSESLPANQQPRDLNRMEKTSVKDMADLPVPNQDVTSDDKQALKSTINEALPKDVSEDPATPKDSN
SLKARPRSRSYSSTSIEEAMKRGEDPPTPPPRPQKTHSRASSLDLNKVFQPSVPATKSGLLPPPPALPPRPCPSQVSYVKAIDIWMAVCL
LFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQNKEEDVTRESRFNFSGYGMGHCLQVKDGTAVKATPANPLPQPPKDGDAIKKKFVDRA

--------------------------------------------------------------
>73476_73476_3_REPS2-GLRA2_REPS2_chrX_17121902_ENST00000303843_GLRA2_chrX_14708832_ENST00000443437_length(transcript)=3328nt_BP=1575nt
ATGGAGGCGGCAGCGGCGGCGGCGGCGGCGGCAGCGGCAGCGGCAGCGGCGGGCGGGGGCTGTGGCTCCGGGCCGCCGCCGCTGCTGCTG
AGCGAGGGCGAGCAGCAGTGCTACTCCGAGCTCTTCGCGCGCTGTGCCGGCGCCGCGGGCGGGGGCCCCGGGTCTGGGCCCCCCGAGGCC
GCCAGAGTCGCCCCCGGCACGGCCACTGCGGCCGCCGGCCCCGTGGCTGACCTGTTTCGGGCATCGCAGCTGCCCGCCGAGACGCTGCAC
CAGATCACAGAACTGTGTGGTGCAAAGCGGGTTGGTTATTTTGGTCCAACACAGTTTTACATTGCCCTGAAATTAATTGCTGCAGCACAA
TCTGGCCTCCCGGTACGGATAGAGAGTATTAAATGTGAATTGCCTCTGCCTCGCTTTATGATGTCAAAGAATGATGGTGAGATACGATTT
GGGAACCCAGCTGAGCTGCATGGAACTAAGGTTCAGATTCCATATTTAACTACAGAAAAAAATTCCTTCAAAAGAATGGACGATGAGGAT
AAACAGGAAACACAGTCTCCCACGATGTCACCCCTCGCCTCCCCTCCTTCTTCCCCGCCTCATTACCAGAGGGTGCCCTTGAGCCATGGC
TACAGCAAACTGCGGAGCAGCGCAGAACAGATGCATCCAGCACCTTATGAAGCTAGGCAGCCCCTTGTCCAGCCCGAGGGATCCTCATCA
GGGGGCCCAGGAACCAAGCCCCTTCGGCATCAGGCTTCCCTTATCCGGTCCTTTTCAGTGGAGAGGGAACTACAGGATAACAGCAGTTAC
CCCGACGAACCCTGGAGGATAACAGAAGAACAGCGCGAGTACTATGTCAATCAGTTCCGATCCCTTCAGCCAGACCCAAGCTCTTTCATT
TCAGGTTCTGTGGCCAAGAACTTCTTCACCAAATCAAAGCTTTCCATTCCAGAACTCTCCTATATATGGGAGCTTAGTGATGCTGACTGT
GATGGAGCCCTGACCCTGCCTGAGTTCTGTGCTGCGTTTCATCTCATTGTGGCTCGGAAGAACGGCTACCCATTGCCTGAGGGCCTCCCT
CCAACTCTGCAGCCAGAATACCTGCAGGCAGCTTTTCCTAAGCCCAAATGGGACTGTCAATTATTTGATTCTTATTCTGAGTCACTGCCG
GCAAATCAACAACCTCGTGACTTGAATCGGATGGAGAAGACATCTGTTAAAGACATGGCTGACCTTCCTGTCCCTAACCAGGATGTAACT
AGTGATGACAAACAAGCTTTGAAAAGTACTATCAATGAAGCCTTACCAAAGGACGTGTCTGAGGATCCAGCAACTCCCAAGGATTCCAAC
AGTCTCAAAGCAAGACCAAGATCCAGATCTTACTCTAGCACCTCCATAGAAGAGGCCATGAAAAGGGGCGAGGACCCTCCCACCCCGCCA
CCTCGGCCACAGAAAACCCATTCCAGAGCCTCCTCCTTGGATCTGAATAAAGTCTTCCAGCCCAGTGTGCCAGCTACCAAGTCAGGATTG
TTACCCCCACCACCTGCGCTCCCTCCAAGACCTTGTCCATCACAGGTCTCCTATGTAAAAGCGATTGACATCTGGATGGCGGTGTGCCTT
CTGTTTGTGTTTGCTGCCTTACTGGAATACGCAGCGGTGAACTTCGTCTCCAGGCAACACAAGGAGTTCCTGCGCCTCCGAAGAAGACAG
AAGAGGCAGAATAAGGAAGAAGACGTTACTCGTGAAAGTCGTTTTAATTTTAGCGGTTATGGGATGGGTCACTGCCTCCAAGTGAAAGAT
GGAACAGCTGTCAAGGCCACACCTGCCAACCCACTCCCACAACCGCCAAAAGATGGAGATGCTATCAAGAAGAAGTTTGTGGACCGGGCA
AAAAGGATTGACACGATATCTCGAGCTGCCTTCCCATTGGCCTTCCTCATTTTCAACATCTTTTACTGGATCACATACAAGATCATTCGG
CATGAAGATGTCCACAAGAAATAGATGTGCCCTACAGACCCTGGGACCTTCTTGCCTCAGTGTTGTGCTTGTAAATACACAGTGAAATTG
TCTTTATATCACTTTGACAGAGGAGAAGATTGAGGGAGGGGGGAGGGAGGGTCATGGGGGTGGGTTTCCTGGCACCTACATGAAAAAAAA
GACAAGTTATATGGGTGATGAAGAAAACTGCACAAAATTAAGGGGTTGCAGAATCACGGGAGCATAATAATTCCCTTCCATAATCTTTAG
CATTGTTCTTTCAGTCAGACATGATATGCGCAACATTCAGACATGATATGCGCATCATTCAGACATGATATGCGGGGTCAAGTTCTTAAG
GGCTGTTTGCCTTTTGGTCCTTTTGGTTTGGTTTGGCTTTGACTAATTCTGGTACTGAAAAGTTAGCTATACACACACACACACACACAC
ACACACACACACACACACACACACACACACACACACACAAACTTCAAAAATGCTTAACCATCTGACCATAGTGACTAGCCTATAGTGAGT
CGAGGACCAAACTTTTTCAGGAAAATGCTGCCTCGTTTTTAAAACAAGCCTCCTAAGCTATGTTCTTTACAATGTCTGTAATTAGTGTTT
CACTTGAGAAAGCCTTTTGTGGGTCGTAAATTATTTCTACTTATCCAGTAAATAACAATGACAAAATAAACACCAATGACAGAAAAATTT
CTACTTTACTGTCCATATAGGTGTGCATTTTAATATTTTTCTTTCCAAGATAAAATTTTGAAACTTAAATTGTGTATTGTGTAATTAATT
TGATAGTGTACCCTCTTAATAAATGCCCACTTTATTTTATATCCAAGTTAGTGCATTATATATATATTTTTGCTTTGGCTATATTTACAC
GTGACTTTAATCGCCCAACTGTGACTAGTCATTGCAGCTACTCAGCTACAGTATTTATGGAGATGGTGTGTCCTGAACAGTGTAGCTCAG
GTCAGCTTGAACTTTCCATTTCTGCTCTCATTGTAGGTGTAACTACTAGTCCTAATGTCAACTGACCCATGATTTCTACTGTCAGTCAAT
ATAAGTGAACATTGTTTTAAATATCCTTAACTAACTTAAAGAATTTTAAAATTGTACTGTGATTTTCATAACCCGTTGCCTTTTTGGTAC
CAGAGCTACGTGGTTTGAATTCTGGCTACATGTTTTAAGTAAGAAAAAAAAAGACGTATTTTTGCTTACTCAGATAAAAGACAACCTGTA

>73476_73476_3_REPS2-GLRA2_REPS2_chrX_17121902_ENST00000303843_GLRA2_chrX_14708832_ENST00000443437_length(amino acids)=667AA_BP=523
MEAAAAAAAAAAAAAAAGGGCGSGPPPLLLSEGEQQCYSELFARCAGAAGGGPGSGPPEAARVAPGTATAAAGPVADLFRASQLPAETLH
QITELCGAKRVGYFGPTQFYIALKLIAAAQSGLPVRIESIKCELPLPRFMMSKNDGEIRFGNPAELHGTKVQIPYLTTEKNSFKRMDDED
KQETQSPTMSPLASPPSSPPHYQRVPLSHGYSKLRSSAEQMHPAPYEARQPLVQPEGSSSGGPGTKPLRHQASLIRSFSVERELQDNSSY
PDEPWRITEEQREYYVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIPELSYIWELSDADCDGALTLPEFCAAFHLIVARKNGYPLPEGLP
PTLQPEYLQAAFPKPKWDCQLFDSYSESLPANQQPRDLNRMEKTSVKDMADLPVPNQDVTSDDKQALKSTINEALPKDVSEDPATPKDSN
SLKARPRSRSYSSTSIEEAMKRGEDPPTPPPRPQKTHSRASSLDLNKVFQPSVPATKSGLLPPPPALPPRPCPSQVSYVKAIDIWMAVCL
LFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQNKEEDVTRESRFNFSGYGMGHCLQVKDGTAVKATPANPLPQPPKDGDAIKKKFVDRA

--------------------------------------------------------------
>73476_73476_4_REPS2-GLRA2_REPS2_chrX_17121902_ENST00000357277_GLRA2_chrX_14708832_ENST00000218075_length(transcript)=3505nt_BP=1749nt
CCGGGAGGAAGCGGCCGCGCGGCAGCTGCGGGGCGTGGGGGTGGTGGTGGCGGCGGCGGTGGTGGCGGCGGCGGCGGCGGCGGCAGCTGA
GGCCGAGGAGGCGGTGGCTGTGGCGGACGCAGCAGCACCCCAGCTAGGGACAGGGCTCCGCCGCGCCCCCTTGCTGGCCCCATGGAGGCG
GCAGCGGCGGCGGCGGCGGCGGCAGCGGCAGCGGCAGCGGCGGGCGGGGGCTGTGGCTCCGGGCCGCCGCCGCTGCTGCTGAGCGAGGGC
GAGCAGCAGTGCTACTCCGAGCTCTTCGCGCGCTGTGCCGGCGCCGCGGGCGGGGGCCCCGGGTCTGGGCCCCCCGAGGCCGCCAGAGTC
GCCCCCGGCACGGCCACTGCGGCCGCCGGCCCCGTGGCTGACCTGTTTCGGGCATCGCAGCTGCCCGCCGAGACGCTGCACCAGATCACA
GAACTGTGTGGTGCAAAGCGGGTTGGTTATTTTGGTCCAACACAGTTTTACATTGCCCTGAAATTAATTGCTGCAGCACAATCTGGCCTC
CCGGTACGGATAGAGAGTATTAAATGTGAATTGCCTCTGCCTCGCTTTATGATGTCAAAGAATGATGGTGAGATACGATTTGGGAACCCA
GCTGAGCTGCATGGAACTAAGGTTCAGATTCCATATTTAACTACAGAAAAAAATTCCTTCAAAAGAATGGACGATGAGGATAAACAGCAG
GAAACACAGTCTCCCACGATGTCACCCCTCGCCTCCCCTCCTTCTTCCCCGCCTCATTACCAGAGGGTGCCCTTGAGCCATGGCTACAGC
AAACTGCGGAGCAGCGCAGAACAGATGCATCCAGCACCTTATGAAGCTAGGCAGCCCCTTGTCCAGCCCGAGGGATCCTCATCAGGGGGC
CCAGGAACCAAGCCCCTTCGGCATCAGGCTTCCCTTATCCGGTCCTTTTCAGTGGAGAGGGAACTACAGGATAACAGCAGTTACCCCGAC
GAACCCTGGAGGATAACAGAAGAACAGCGCGAGTACTATGTCAATCAGTTCCGATCCCTTCAGCCAGACCCAAGCTCTTTCATTTCAGGT
TCTGTGGCCAAGAACTTCTTCACCAAATCAAAGCTTTCCATTCCAGAACTCTCCTATATATGGGAGCTTAGTGATGCTGACTGTGATGGA
GCCCTGACCCTGCCTGAGTTCTGTGCTGCGTTTCATCTCATTGTGGCTCGGAAGAACGGCTACCCATTGCCTGAGGGCCTCCCTCCAACT
CTGCAGCCAGAATACCTGCAGGCAGCTTTTCCTAAGCCCAAATGGGACTGTCAATTATTTGATTCTTATTCTGAGTCACTGCCGGCAAAT
CAACAACCTCGTGACTTGAATCGGATGGAGAAGACATCTGTTAAAGACATGGCTGACCTTCCTGTCCCTAACCAGGATGTAACTAGTGAT
GACAAACAAGCTTTGAAAAGTACTATCAATGAAGCCTTACCAAAGGACGTGTCTGAGGATCCAGCAACTCCCAAGGATTCCAACAGTCTC
AAAGCAAGACCAAGATCCAGATCTTACTCTAGCACCTCCATAGAAGAGGCCATGAAAAGGGGCGAGGACCCTCCCACCCCGCCACCTCGG
CCACAGAAAACCCATTCCAGAGCCTCCTCCTTGGATCTGAATAAAGTCTTCCAGCCCAGTGTGCCAGCTACCAAGTCAGGATTGTTACCC
CCACCACCTGCGCTCCCTCCAAGACCTTGTCCATCACAGGTCTCCTATGTAAAAGCGATTGACATCTGGATGGCGGTGTGCCTTCTGTTT
GTGTTTGCTGCCTTACTGGAATACGCAGCGGTGAACTTCGTCTCCAGGCAACACAAGGAGTTCCTGCGCCTCCGAAGAAGACAGAAGAGG
CAGAATAAGGAAGAAGACGTTACTCGTGAAAGTCGTTTTAATTTTAGCGGTTATGGGATGGGTCACTGCCTCCAAGTGAAAGATGGAACA
GCTGTCAAGGCCACACCTGCCAACCCACTCCCACAACCGCCAAAAGATGGAGATGCTATCAAGAAGAAGTTTGTGGACCGGGCAAAAAGG
ATTGACACGATATCTCGAGCTGCCTTCCCATTGGCCTTCCTCATTTTCAACATCTTTTACTGGATCACATACAAGATCATTCGGCATGAA
GATGTCCACAAGAAATAGATGTGCCCTACAGACCCTGGGACCTTCTTGCCTCAGTGTTGTGCTTGTAAATACACAGTGAAATTGTCTTTA
TATCACTTTGACAGAGGAGAAGATTGAGGGAGGGGGGAGGGAGGGTCATGGGGGTGGGTTTCCTGGCACCTACATGAAAAAAAAGACAAG
TTATATGGGTGATGAAGAAAACTGCACAAAATTAAGGGGTTGCAGAATCACGGGAGCATAATAATTCCCTTCCATAATCTTTAGCATTGT
TCTTTCAGTCAGACATGATATGCGCAACATTCAGACATGATATGCGCATCATTCAGACATGATATGCGGGGTCAAGTTCTTAAGGGCTGT
TTGCCTTTTGGTCCTTTTGGTTTGGTTTGGCTTTGACTAATTCTGGTACTGAAAAGTTAGCTATACACACACACACACACACACACACAC
ACACACACACACACACACACACACACACACACAAACTTCAAAAATGCTTAACCATCTGACCATAGTGACTAGCCTATAGTGAGTCGAGGA
CCAAACTTTTTCAGGAAAATGCTGCCTCGTTTTTAAAACAAGCCTCCTAAGCTATGTTCTTTACAATGTCTGTAATTAGTGTTTCACTTG
AGAAAGCCTTTTGTGGGTCGTAAATTATTTCTACTTATCCAGTAAATAACAATGACAAAATAAACACCAATGACAGAAAAATTTCTACTT
TACTGTCCATATAGGTGTGCATTTTAATATTTTTCTTTCCAAGATAAAATTTTGAAACTTAAATTGTGTATTGTGTAATTAATTTGATAG
TGTACCCTCTTAATAAATGCCCACTTTATTTTATATCCAAGTTAGTGCATTATATATATATTTTTGCTTTGGCTATATTTACACGTGACT
TTAATCGCCCAACTGTGACTAGTCATTGCAGCTACTCAGCTACAGTATTTATGGAGATGGTGTGTCCTGAACAGTGTAGCTCAGGTCAGC
TTGAACTTTCCATTTCTGCTCTCATTGTAGGTGTAACTACTAGTCCTAATGTCAACTGACCCATGATTTCTACTGTCAGTCAATATAAGT
GAACATTGTTTTAAATATCCTTAACTAACTTAAAGAATTTTAAAATTGTACTGTGATTTTCATAACCCGTTGCCTTTTTGGTACCAGAGC
TACGTGGTTTGAATTCTGGCTACATGTTTTAAGTAAGAAAAAAAAAGACGTATTTTTGCTTACTCAGATAAAAGACAACCTGTAAAAATA

>73476_73476_4_REPS2-GLRA2_REPS2_chrX_17121902_ENST00000357277_GLRA2_chrX_14708832_ENST00000218075_length(amino acids)=668AA_BP=524
MEAAAAAAAAAAAAAAAGGGCGSGPPPLLLSEGEQQCYSELFARCAGAAGGGPGSGPPEAARVAPGTATAAAGPVADLFRASQLPAETLH
QITELCGAKRVGYFGPTQFYIALKLIAAAQSGLPVRIESIKCELPLPRFMMSKNDGEIRFGNPAELHGTKVQIPYLTTEKNSFKRMDDED
KQQETQSPTMSPLASPPSSPPHYQRVPLSHGYSKLRSSAEQMHPAPYEARQPLVQPEGSSSGGPGTKPLRHQASLIRSFSVERELQDNSS
YPDEPWRITEEQREYYVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIPELSYIWELSDADCDGALTLPEFCAAFHLIVARKNGYPLPEGL
PPTLQPEYLQAAFPKPKWDCQLFDSYSESLPANQQPRDLNRMEKTSVKDMADLPVPNQDVTSDDKQALKSTINEALPKDVSEDPATPKDS
NSLKARPRSRSYSSTSIEEAMKRGEDPPTPPPRPQKTHSRASSLDLNKVFQPSVPATKSGLLPPPPALPPRPCPSQVSYVKAIDIWMAVC
LLFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQNKEEDVTRESRFNFSGYGMGHCLQVKDGTAVKATPANPLPQPPKDGDAIKKKFVDR

--------------------------------------------------------------
>73476_73476_5_REPS2-GLRA2_REPS2_chrX_17121902_ENST00000357277_GLRA2_chrX_14708832_ENST00000355020_length(transcript)=2263nt_BP=1749nt
CCGGGAGGAAGCGGCCGCGCGGCAGCTGCGGGGCGTGGGGGTGGTGGTGGCGGCGGCGGTGGTGGCGGCGGCGGCGGCGGCGGCAGCTGA
GGCCGAGGAGGCGGTGGCTGTGGCGGACGCAGCAGCACCCCAGCTAGGGACAGGGCTCCGCCGCGCCCCCTTGCTGGCCCCATGGAGGCG
GCAGCGGCGGCGGCGGCGGCGGCAGCGGCAGCGGCAGCGGCGGGCGGGGGCTGTGGCTCCGGGCCGCCGCCGCTGCTGCTGAGCGAGGGC
GAGCAGCAGTGCTACTCCGAGCTCTTCGCGCGCTGTGCCGGCGCCGCGGGCGGGGGCCCCGGGTCTGGGCCCCCCGAGGCCGCCAGAGTC
GCCCCCGGCACGGCCACTGCGGCCGCCGGCCCCGTGGCTGACCTGTTTCGGGCATCGCAGCTGCCCGCCGAGACGCTGCACCAGATCACA
GAACTGTGTGGTGCAAAGCGGGTTGGTTATTTTGGTCCAACACAGTTTTACATTGCCCTGAAATTAATTGCTGCAGCACAATCTGGCCTC
CCGGTACGGATAGAGAGTATTAAATGTGAATTGCCTCTGCCTCGCTTTATGATGTCAAAGAATGATGGTGAGATACGATTTGGGAACCCA
GCTGAGCTGCATGGAACTAAGGTTCAGATTCCATATTTAACTACAGAAAAAAATTCCTTCAAAAGAATGGACGATGAGGATAAACAGCAG
GAAACACAGTCTCCCACGATGTCACCCCTCGCCTCCCCTCCTTCTTCCCCGCCTCATTACCAGAGGGTGCCCTTGAGCCATGGCTACAGC
AAACTGCGGAGCAGCGCAGAACAGATGCATCCAGCACCTTATGAAGCTAGGCAGCCCCTTGTCCAGCCCGAGGGATCCTCATCAGGGGGC
CCAGGAACCAAGCCCCTTCGGCATCAGGCTTCCCTTATCCGGTCCTTTTCAGTGGAGAGGGAACTACAGGATAACAGCAGTTACCCCGAC
GAACCCTGGAGGATAACAGAAGAACAGCGCGAGTACTATGTCAATCAGTTCCGATCCCTTCAGCCAGACCCAAGCTCTTTCATTTCAGGT
TCTGTGGCCAAGAACTTCTTCACCAAATCAAAGCTTTCCATTCCAGAACTCTCCTATATATGGGAGCTTAGTGATGCTGACTGTGATGGA
GCCCTGACCCTGCCTGAGTTCTGTGCTGCGTTTCATCTCATTGTGGCTCGGAAGAACGGCTACCCATTGCCTGAGGGCCTCCCTCCAACT
CTGCAGCCAGAATACCTGCAGGCAGCTTTTCCTAAGCCCAAATGGGACTGTCAATTATTTGATTCTTATTCTGAGTCACTGCCGGCAAAT
CAACAACCTCGTGACTTGAATCGGATGGAGAAGACATCTGTTAAAGACATGGCTGACCTTCCTGTCCCTAACCAGGATGTAACTAGTGAT
GACAAACAAGCTTTGAAAAGTACTATCAATGAAGCCTTACCAAAGGACGTGTCTGAGGATCCAGCAACTCCCAAGGATTCCAACAGTCTC
AAAGCAAGACCAAGATCCAGATCTTACTCTAGCACCTCCATAGAAGAGGCCATGAAAAGGGGCGAGGACCCTCCCACCCCGCCACCTCGG
CCACAGAAAACCCATTCCAGAGCCTCCTCCTTGGATCTGAATAAAGTCTTCCAGCCCAGTGTGCCAGCTACCAAGTCAGGATTGTTACCC
CCACCACCTGCGCTCCCTCCAAGACCTTGTCCATCACAGGTCTCCTATGTAAAAGCGATTGACATCTGGATGGCGGTGTGCCTTCTGTTT
GTGTTTGCTGCCTTACTGGAATACGCAGCGGTGAACTTCGTCTCCAGGCAACACAAGGAGTTCCTGCGCCTCCGAAGAAGACAGAAGAGG
CAGAATAAGGAAGAAGACGTTACTCGTGAAAGTCGTTTTAATTTTAGCGGTTATGGGATGGGTCACTGCCTCCAAGTGAAAGATGGAACA
GCTGTCAAGGCCACACCTGCCAACCCACTCCCACAACCGCCAAAAGATGGAGATGCTATCAAGAAGAAGTTTGTGGACCGGGCAAAAAGG
ATTGACACGATATCTCGAGCTGCCTTCCCATTGGCCTTCCTCATTTTCAACATCTTTTACTGGATCACATACAAGATCATTCGGCATGAA
GATGTCCACAAGAAATAGATGTGCCCTACAGACCCTGGGACCTTCTTGCCTCAGTGTTGTGCTTGTAAATACACAGTGAAATTGTCTTTA

>73476_73476_5_REPS2-GLRA2_REPS2_chrX_17121902_ENST00000357277_GLRA2_chrX_14708832_ENST00000355020_length(amino acids)=668AA_BP=524
MEAAAAAAAAAAAAAAAGGGCGSGPPPLLLSEGEQQCYSELFARCAGAAGGGPGSGPPEAARVAPGTATAAAGPVADLFRASQLPAETLH
QITELCGAKRVGYFGPTQFYIALKLIAAAQSGLPVRIESIKCELPLPRFMMSKNDGEIRFGNPAELHGTKVQIPYLTTEKNSFKRMDDED
KQQETQSPTMSPLASPPSSPPHYQRVPLSHGYSKLRSSAEQMHPAPYEARQPLVQPEGSSSGGPGTKPLRHQASLIRSFSVERELQDNSS
YPDEPWRITEEQREYYVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIPELSYIWELSDADCDGALTLPEFCAAFHLIVARKNGYPLPEGL
PPTLQPEYLQAAFPKPKWDCQLFDSYSESLPANQQPRDLNRMEKTSVKDMADLPVPNQDVTSDDKQALKSTINEALPKDVSEDPATPKDS
NSLKARPRSRSYSSTSIEEAMKRGEDPPTPPPRPQKTHSRASSLDLNKVFQPSVPATKSGLLPPPPALPPRPCPSQVSYVKAIDIWMAVC
LLFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQNKEEDVTRESRFNFSGYGMGHCLQVKDGTAVKATPANPLPQPPKDGDAIKKKFVDR

--------------------------------------------------------------
>73476_73476_6_REPS2-GLRA2_REPS2_chrX_17121902_ENST00000357277_GLRA2_chrX_14708832_ENST00000443437_length(transcript)=3502nt_BP=1749nt
CCGGGAGGAAGCGGCCGCGCGGCAGCTGCGGGGCGTGGGGGTGGTGGTGGCGGCGGCGGTGGTGGCGGCGGCGGCGGCGGCGGCAGCTGA
GGCCGAGGAGGCGGTGGCTGTGGCGGACGCAGCAGCACCCCAGCTAGGGACAGGGCTCCGCCGCGCCCCCTTGCTGGCCCCATGGAGGCG
GCAGCGGCGGCGGCGGCGGCGGCAGCGGCAGCGGCAGCGGCGGGCGGGGGCTGTGGCTCCGGGCCGCCGCCGCTGCTGCTGAGCGAGGGC
GAGCAGCAGTGCTACTCCGAGCTCTTCGCGCGCTGTGCCGGCGCCGCGGGCGGGGGCCCCGGGTCTGGGCCCCCCGAGGCCGCCAGAGTC
GCCCCCGGCACGGCCACTGCGGCCGCCGGCCCCGTGGCTGACCTGTTTCGGGCATCGCAGCTGCCCGCCGAGACGCTGCACCAGATCACA
GAACTGTGTGGTGCAAAGCGGGTTGGTTATTTTGGTCCAACACAGTTTTACATTGCCCTGAAATTAATTGCTGCAGCACAATCTGGCCTC
CCGGTACGGATAGAGAGTATTAAATGTGAATTGCCTCTGCCTCGCTTTATGATGTCAAAGAATGATGGTGAGATACGATTTGGGAACCCA
GCTGAGCTGCATGGAACTAAGGTTCAGATTCCATATTTAACTACAGAAAAAAATTCCTTCAAAAGAATGGACGATGAGGATAAACAGCAG
GAAACACAGTCTCCCACGATGTCACCCCTCGCCTCCCCTCCTTCTTCCCCGCCTCATTACCAGAGGGTGCCCTTGAGCCATGGCTACAGC
AAACTGCGGAGCAGCGCAGAACAGATGCATCCAGCACCTTATGAAGCTAGGCAGCCCCTTGTCCAGCCCGAGGGATCCTCATCAGGGGGC
CCAGGAACCAAGCCCCTTCGGCATCAGGCTTCCCTTATCCGGTCCTTTTCAGTGGAGAGGGAACTACAGGATAACAGCAGTTACCCCGAC
GAACCCTGGAGGATAACAGAAGAACAGCGCGAGTACTATGTCAATCAGTTCCGATCCCTTCAGCCAGACCCAAGCTCTTTCATTTCAGGT
TCTGTGGCCAAGAACTTCTTCACCAAATCAAAGCTTTCCATTCCAGAACTCTCCTATATATGGGAGCTTAGTGATGCTGACTGTGATGGA
GCCCTGACCCTGCCTGAGTTCTGTGCTGCGTTTCATCTCATTGTGGCTCGGAAGAACGGCTACCCATTGCCTGAGGGCCTCCCTCCAACT
CTGCAGCCAGAATACCTGCAGGCAGCTTTTCCTAAGCCCAAATGGGACTGTCAATTATTTGATTCTTATTCTGAGTCACTGCCGGCAAAT
CAACAACCTCGTGACTTGAATCGGATGGAGAAGACATCTGTTAAAGACATGGCTGACCTTCCTGTCCCTAACCAGGATGTAACTAGTGAT
GACAAACAAGCTTTGAAAAGTACTATCAATGAAGCCTTACCAAAGGACGTGTCTGAGGATCCAGCAACTCCCAAGGATTCCAACAGTCTC
AAAGCAAGACCAAGATCCAGATCTTACTCTAGCACCTCCATAGAAGAGGCCATGAAAAGGGGCGAGGACCCTCCCACCCCGCCACCTCGG
CCACAGAAAACCCATTCCAGAGCCTCCTCCTTGGATCTGAATAAAGTCTTCCAGCCCAGTGTGCCAGCTACCAAGTCAGGATTGTTACCC
CCACCACCTGCGCTCCCTCCAAGACCTTGTCCATCACAGGTCTCCTATGTAAAAGCGATTGACATCTGGATGGCGGTGTGCCTTCTGTTT
GTGTTTGCTGCCTTACTGGAATACGCAGCGGTGAACTTCGTCTCCAGGCAACACAAGGAGTTCCTGCGCCTCCGAAGAAGACAGAAGAGG
CAGAATAAGGAAGAAGACGTTACTCGTGAAAGTCGTTTTAATTTTAGCGGTTATGGGATGGGTCACTGCCTCCAAGTGAAAGATGGAACA
GCTGTCAAGGCCACACCTGCCAACCCACTCCCACAACCGCCAAAAGATGGAGATGCTATCAAGAAGAAGTTTGTGGACCGGGCAAAAAGG
ATTGACACGATATCTCGAGCTGCCTTCCCATTGGCCTTCCTCATTTTCAACATCTTTTACTGGATCACATACAAGATCATTCGGCATGAA
GATGTCCACAAGAAATAGATGTGCCCTACAGACCCTGGGACCTTCTTGCCTCAGTGTTGTGCTTGTAAATACACAGTGAAATTGTCTTTA
TATCACTTTGACAGAGGAGAAGATTGAGGGAGGGGGGAGGGAGGGTCATGGGGGTGGGTTTCCTGGCACCTACATGAAAAAAAAGACAAG
TTATATGGGTGATGAAGAAAACTGCACAAAATTAAGGGGTTGCAGAATCACGGGAGCATAATAATTCCCTTCCATAATCTTTAGCATTGT
TCTTTCAGTCAGACATGATATGCGCAACATTCAGACATGATATGCGCATCATTCAGACATGATATGCGGGGTCAAGTTCTTAAGGGCTGT
TTGCCTTTTGGTCCTTTTGGTTTGGTTTGGCTTTGACTAATTCTGGTACTGAAAAGTTAGCTATACACACACACACACACACACACACAC
ACACACACACACACACACACACACACACACACAAACTTCAAAAATGCTTAACCATCTGACCATAGTGACTAGCCTATAGTGAGTCGAGGA
CCAAACTTTTTCAGGAAAATGCTGCCTCGTTTTTAAAACAAGCCTCCTAAGCTATGTTCTTTACAATGTCTGTAATTAGTGTTTCACTTG
AGAAAGCCTTTTGTGGGTCGTAAATTATTTCTACTTATCCAGTAAATAACAATGACAAAATAAACACCAATGACAGAAAAATTTCTACTT
TACTGTCCATATAGGTGTGCATTTTAATATTTTTCTTTCCAAGATAAAATTTTGAAACTTAAATTGTGTATTGTGTAATTAATTTGATAG
TGTACCCTCTTAATAAATGCCCACTTTATTTTATATCCAAGTTAGTGCATTATATATATATTTTTGCTTTGGCTATATTTACACGTGACT
TTAATCGCCCAACTGTGACTAGTCATTGCAGCTACTCAGCTACAGTATTTATGGAGATGGTGTGTCCTGAACAGTGTAGCTCAGGTCAGC
TTGAACTTTCCATTTCTGCTCTCATTGTAGGTGTAACTACTAGTCCTAATGTCAACTGACCCATGATTTCTACTGTCAGTCAATATAAGT
GAACATTGTTTTAAATATCCTTAACTAACTTAAAGAATTTTAAAATTGTACTGTGATTTTCATAACCCGTTGCCTTTTTGGTACCAGAGC
TACGTGGTTTGAATTCTGGCTACATGTTTTAAGTAAGAAAAAAAAAGACGTATTTTTGCTTACTCAGATAAAAGACAACCTGTAAAAATA

>73476_73476_6_REPS2-GLRA2_REPS2_chrX_17121902_ENST00000357277_GLRA2_chrX_14708832_ENST00000443437_length(amino acids)=668AA_BP=524
MEAAAAAAAAAAAAAAAGGGCGSGPPPLLLSEGEQQCYSELFARCAGAAGGGPGSGPPEAARVAPGTATAAAGPVADLFRASQLPAETLH
QITELCGAKRVGYFGPTQFYIALKLIAAAQSGLPVRIESIKCELPLPRFMMSKNDGEIRFGNPAELHGTKVQIPYLTTEKNSFKRMDDED
KQQETQSPTMSPLASPPSSPPHYQRVPLSHGYSKLRSSAEQMHPAPYEARQPLVQPEGSSSGGPGTKPLRHQASLIRSFSVERELQDNSS
YPDEPWRITEEQREYYVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIPELSYIWELSDADCDGALTLPEFCAAFHLIVARKNGYPLPEGL
PPTLQPEYLQAAFPKPKWDCQLFDSYSESLPANQQPRDLNRMEKTSVKDMADLPVPNQDVTSDDKQALKSTINEALPKDVSEDPATPKDS
NSLKARPRSRSYSSTSIEEAMKRGEDPPTPPPRPQKTHSRASSLDLNKVFQPSVPATKSGLLPPPPALPPRPCPSQVSYVKAIDIWMAVC
LLFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQNKEEDVTRESRFNFSGYGMGHCLQVKDGTAVKATPANPLPQPPKDGDAIKKKFVDR

--------------------------------------------------------------
>73476_73476_7_REPS2-GLRA2_REPS2_chrX_17121902_ENST00000380064_GLRA2_chrX_14708832_ENST00000218075_length(transcript)=2933nt_BP=1177nt
AGGATGCTCTGAGCTCTAAAAGGAGGAGCAGTTTTGCTGGCATGCAGAAGTGGTGAAGATCACAGAACTGTGTGGTGCAAAGCGGGTTGG
TTATTTTGGTCCAACACAGTTTTACATTGCCCTGAAATTAATTGCTGCAGCACAATCTGGCCTCCCGGTACGGATAGAGAGTATTAAATG
TGAATTGCCTCTGCCTCGCTTTATGATGTCAAAGAATGATGGTGAGATACGATTTGGGAACCCAGCTGAGCTGCATGGAACTAAGGTTCA
GATTCCATATTTAACTACAGAAAAAAATTCCTTCAAAAGAATGGACGATGAGGATAAACAGGAAACACAGTCTCCCACGATGTCACCCCT
CGCCTCCCCTCCTTCTTCCCCGCCTCATTACCAGAGGGTGCCCTTGAGCCATGGCTACAGCAAACTGCGGAGCAGCGCAGAACAGATGCA
TCCAGCACCTTATGAAGCTAGGCAGCCCCTTGTCCAGCCCGAGGGATCCTCATCAGGGGGCCCAGGAACCAAGCCCCTTCGGCATCAGGC
TTCCCTTATCCGGTCCTTTTCAGTGGAGAGGGAACTACAGGATAACAGCAGTTACCCCGACGAACCCTGGAGGATAACAGAAGAACAGCG
CGAGTACTATGTCAATCAGTTCCGATCCCTTCAGCCAGACCCAAGCTCTTTCATTTCAGGTTCTGTGGCCAAGAACTTCTTCACCAAATC
AAAGCTTTCCATTCCAGAACTCTCCTATATATGGGAGCTTAGTGATGCTGACTGTGATGGAGCCCTGACCCTGCCTGAGTTCTGTGCTGC
GTTTCATCTCATTGTGGCTCGGAAGAACGGCTACCCATTGCCTGAGGGCCTCCCTCCAACTCTGCAGCCAGAATACCTGCAGGCAGCTTT
TCCTAAGCCCAAATGGGACTGTCAATTATTTGATTCTTATTCTGAGTCACTGCCGGCAAATCAACAACCTCGTGACTTGAATCGGATGGA
GAAGACATCTGTTAAAGACATGGCTGACCTTCCTGTCCCTAACCAGGATGTAACTAGTGATGACAAACAAGCTTTGAAAAGTACTATCAA
TGAAGCCTTACCAAAGGACGTGTCTGAGGATCCAGCTACCAAGTCAGGATTGTTACCCCCACCACCTGCGCTCCCTCCAAGACCTTGTCC
ATCACAGGTCTCCTATGTAAAAGCGATTGACATCTGGATGGCGGTGTGCCTTCTGTTTGTGTTTGCTGCCTTACTGGAATACGCAGCGGT
GAACTTCGTCTCCAGGCAACACAAGGAGTTCCTGCGCCTCCGAAGAAGACAGAAGAGGCAGAATAAGGAAGAAGACGTTACTCGTGAAAG
TCGTTTTAATTTTAGCGGTTATGGGATGGGTCACTGCCTCCAAGTGAAAGATGGAACAGCTGTCAAGGCCACACCTGCCAACCCACTCCC
ACAACCGCCAAAAGATGGAGATGCTATCAAGAAGAAGTTTGTGGACCGGGCAAAAAGGATTGACACGATATCTCGAGCTGCCTTCCCATT
GGCCTTCCTCATTTTCAACATCTTTTACTGGATCACATACAAGATCATTCGGCATGAAGATGTCCACAAGAAATAGATGTGCCCTACAGA
CCCTGGGACCTTCTTGCCTCAGTGTTGTGCTTGTAAATACACAGTGAAATTGTCTTTATATCACTTTGACAGAGGAGAAGATTGAGGGAG
GGGGGAGGGAGGGTCATGGGGGTGGGTTTCCTGGCACCTACATGAAAAAAAAGACAAGTTATATGGGTGATGAAGAAAACTGCACAAAAT
TAAGGGGTTGCAGAATCACGGGAGCATAATAATTCCCTTCCATAATCTTTAGCATTGTTCTTTCAGTCAGACATGATATGCGCAACATTC
AGACATGATATGCGCATCATTCAGACATGATATGCGGGGTCAAGTTCTTAAGGGCTGTTTGCCTTTTGGTCCTTTTGGTTTGGTTTGGCT
TTGACTAATTCTGGTACTGAAAAGTTAGCTATACACACACACACACACACACACACACACACACACACACACACACACACACACACACAC
AAACTTCAAAAATGCTTAACCATCTGACCATAGTGACTAGCCTATAGTGAGTCGAGGACCAAACTTTTTCAGGAAAATGCTGCCTCGTTT
TTAAAACAAGCCTCCTAAGCTATGTTCTTTACAATGTCTGTAATTAGTGTTTCACTTGAGAAAGCCTTTTGTGGGTCGTAAATTATTTCT
ACTTATCCAGTAAATAACAATGACAAAATAAACACCAATGACAGAAAAATTTCTACTTTACTGTCCATATAGGTGTGCATTTTAATATTT
TTCTTTCCAAGATAAAATTTTGAAACTTAAATTGTGTATTGTGTAATTAATTTGATAGTGTACCCTCTTAATAAATGCCCACTTTATTTT
ATATCCAAGTTAGTGCATTATATATATATTTTTGCTTTGGCTATATTTACACGTGACTTTAATCGCCCAACTGTGACTAGTCATTGCAGC
TACTCAGCTACAGTATTTATGGAGATGGTGTGTCCTGAACAGTGTAGCTCAGGTCAGCTTGAACTTTCCATTTCTGCTCTCATTGTAGGT
GTAACTACTAGTCCTAATGTCAACTGACCCATGATTTCTACTGTCAGTCAATATAAGTGAACATTGTTTTAAATATCCTTAACTAACTTA
AAGAATTTTAAAATTGTACTGTGATTTTCATAACCCGTTGCCTTTTTGGTACCAGAGCTACGTGGTTTGAATTCTGGCTACATGTTTTAA
GTAAGAAAAAAAAAGACGTATTTTTGCTTACTCAGATAAAAGACAACCTGTAAAAATATAATAATTAAATTTTACATGTGCTGTACAAGG

>73476_73476_7_REPS2-GLRA2_REPS2_chrX_17121902_ENST00000380064_GLRA2_chrX_14708832_ENST00000218075_length(amino acids)=512AA_BP=368
MCGAKRVGYFGPTQFYIALKLIAAAQSGLPVRIESIKCELPLPRFMMSKNDGEIRFGNPAELHGTKVQIPYLTTEKNSFKRMDDEDKQET
QSPTMSPLASPPSSPPHYQRVPLSHGYSKLRSSAEQMHPAPYEARQPLVQPEGSSSGGPGTKPLRHQASLIRSFSVERELQDNSSYPDEP
WRITEEQREYYVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIPELSYIWELSDADCDGALTLPEFCAAFHLIVARKNGYPLPEGLPPTLQ
PEYLQAAFPKPKWDCQLFDSYSESLPANQQPRDLNRMEKTSVKDMADLPVPNQDVTSDDKQALKSTINEALPKDVSEDPATKSGLLPPPP
ALPPRPCPSQVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQNKEEDVTRESRFNFSGYGMGHCLQVKDGTAVK

--------------------------------------------------------------
>73476_73476_8_REPS2-GLRA2_REPS2_chrX_17121902_ENST00000380064_GLRA2_chrX_14708832_ENST00000355020_length(transcript)=1691nt_BP=1177nt
AGGATGCTCTGAGCTCTAAAAGGAGGAGCAGTTTTGCTGGCATGCAGAAGTGGTGAAGATCACAGAACTGTGTGGTGCAAAGCGGGTTGG
TTATTTTGGTCCAACACAGTTTTACATTGCCCTGAAATTAATTGCTGCAGCACAATCTGGCCTCCCGGTACGGATAGAGAGTATTAAATG
TGAATTGCCTCTGCCTCGCTTTATGATGTCAAAGAATGATGGTGAGATACGATTTGGGAACCCAGCTGAGCTGCATGGAACTAAGGTTCA
GATTCCATATTTAACTACAGAAAAAAATTCCTTCAAAAGAATGGACGATGAGGATAAACAGGAAACACAGTCTCCCACGATGTCACCCCT
CGCCTCCCCTCCTTCTTCCCCGCCTCATTACCAGAGGGTGCCCTTGAGCCATGGCTACAGCAAACTGCGGAGCAGCGCAGAACAGATGCA
TCCAGCACCTTATGAAGCTAGGCAGCCCCTTGTCCAGCCCGAGGGATCCTCATCAGGGGGCCCAGGAACCAAGCCCCTTCGGCATCAGGC
TTCCCTTATCCGGTCCTTTTCAGTGGAGAGGGAACTACAGGATAACAGCAGTTACCCCGACGAACCCTGGAGGATAACAGAAGAACAGCG
CGAGTACTATGTCAATCAGTTCCGATCCCTTCAGCCAGACCCAAGCTCTTTCATTTCAGGTTCTGTGGCCAAGAACTTCTTCACCAAATC
AAAGCTTTCCATTCCAGAACTCTCCTATATATGGGAGCTTAGTGATGCTGACTGTGATGGAGCCCTGACCCTGCCTGAGTTCTGTGCTGC
GTTTCATCTCATTGTGGCTCGGAAGAACGGCTACCCATTGCCTGAGGGCCTCCCTCCAACTCTGCAGCCAGAATACCTGCAGGCAGCTTT
TCCTAAGCCCAAATGGGACTGTCAATTATTTGATTCTTATTCTGAGTCACTGCCGGCAAATCAACAACCTCGTGACTTGAATCGGATGGA
GAAGACATCTGTTAAAGACATGGCTGACCTTCCTGTCCCTAACCAGGATGTAACTAGTGATGACAAACAAGCTTTGAAAAGTACTATCAA
TGAAGCCTTACCAAAGGACGTGTCTGAGGATCCAGCTACCAAGTCAGGATTGTTACCCCCACCACCTGCGCTCCCTCCAAGACCTTGTCC
ATCACAGGTCTCCTATGTAAAAGCGATTGACATCTGGATGGCGGTGTGCCTTCTGTTTGTGTTTGCTGCCTTACTGGAATACGCAGCGGT
GAACTTCGTCTCCAGGCAACACAAGGAGTTCCTGCGCCTCCGAAGAAGACAGAAGAGGCAGAATAAGGAAGAAGACGTTACTCGTGAAAG
TCGTTTTAATTTTAGCGGTTATGGGATGGGTCACTGCCTCCAAGTGAAAGATGGAACAGCTGTCAAGGCCACACCTGCCAACCCACTCCC
ACAACCGCCAAAAGATGGAGATGCTATCAAGAAGAAGTTTGTGGACCGGGCAAAAAGGATTGACACGATATCTCGAGCTGCCTTCCCATT
GGCCTTCCTCATTTTCAACATCTTTTACTGGATCACATACAAGATCATTCGGCATGAAGATGTCCACAAGAAATAGATGTGCCCTACAGA

>73476_73476_8_REPS2-GLRA2_REPS2_chrX_17121902_ENST00000380064_GLRA2_chrX_14708832_ENST00000355020_length(amino acids)=512AA_BP=368
MCGAKRVGYFGPTQFYIALKLIAAAQSGLPVRIESIKCELPLPRFMMSKNDGEIRFGNPAELHGTKVQIPYLTTEKNSFKRMDDEDKQET
QSPTMSPLASPPSSPPHYQRVPLSHGYSKLRSSAEQMHPAPYEARQPLVQPEGSSSGGPGTKPLRHQASLIRSFSVERELQDNSSYPDEP
WRITEEQREYYVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIPELSYIWELSDADCDGALTLPEFCAAFHLIVARKNGYPLPEGLPPTLQ
PEYLQAAFPKPKWDCQLFDSYSESLPANQQPRDLNRMEKTSVKDMADLPVPNQDVTSDDKQALKSTINEALPKDVSEDPATKSGLLPPPP
ALPPRPCPSQVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQNKEEDVTRESRFNFSGYGMGHCLQVKDGTAVK

--------------------------------------------------------------
>73476_73476_9_REPS2-GLRA2_REPS2_chrX_17121902_ENST00000380064_GLRA2_chrX_14708832_ENST00000443437_length(transcript)=2930nt_BP=1177nt
AGGATGCTCTGAGCTCTAAAAGGAGGAGCAGTTTTGCTGGCATGCAGAAGTGGTGAAGATCACAGAACTGTGTGGTGCAAAGCGGGTTGG
TTATTTTGGTCCAACACAGTTTTACATTGCCCTGAAATTAATTGCTGCAGCACAATCTGGCCTCCCGGTACGGATAGAGAGTATTAAATG
TGAATTGCCTCTGCCTCGCTTTATGATGTCAAAGAATGATGGTGAGATACGATTTGGGAACCCAGCTGAGCTGCATGGAACTAAGGTTCA
GATTCCATATTTAACTACAGAAAAAAATTCCTTCAAAAGAATGGACGATGAGGATAAACAGGAAACACAGTCTCCCACGATGTCACCCCT
CGCCTCCCCTCCTTCTTCCCCGCCTCATTACCAGAGGGTGCCCTTGAGCCATGGCTACAGCAAACTGCGGAGCAGCGCAGAACAGATGCA
TCCAGCACCTTATGAAGCTAGGCAGCCCCTTGTCCAGCCCGAGGGATCCTCATCAGGGGGCCCAGGAACCAAGCCCCTTCGGCATCAGGC
TTCCCTTATCCGGTCCTTTTCAGTGGAGAGGGAACTACAGGATAACAGCAGTTACCCCGACGAACCCTGGAGGATAACAGAAGAACAGCG
CGAGTACTATGTCAATCAGTTCCGATCCCTTCAGCCAGACCCAAGCTCTTTCATTTCAGGTTCTGTGGCCAAGAACTTCTTCACCAAATC
AAAGCTTTCCATTCCAGAACTCTCCTATATATGGGAGCTTAGTGATGCTGACTGTGATGGAGCCCTGACCCTGCCTGAGTTCTGTGCTGC
GTTTCATCTCATTGTGGCTCGGAAGAACGGCTACCCATTGCCTGAGGGCCTCCCTCCAACTCTGCAGCCAGAATACCTGCAGGCAGCTTT
TCCTAAGCCCAAATGGGACTGTCAATTATTTGATTCTTATTCTGAGTCACTGCCGGCAAATCAACAACCTCGTGACTTGAATCGGATGGA
GAAGACATCTGTTAAAGACATGGCTGACCTTCCTGTCCCTAACCAGGATGTAACTAGTGATGACAAACAAGCTTTGAAAAGTACTATCAA
TGAAGCCTTACCAAAGGACGTGTCTGAGGATCCAGCTACCAAGTCAGGATTGTTACCCCCACCACCTGCGCTCCCTCCAAGACCTTGTCC
ATCACAGGTCTCCTATGTAAAAGCGATTGACATCTGGATGGCGGTGTGCCTTCTGTTTGTGTTTGCTGCCTTACTGGAATACGCAGCGGT
GAACTTCGTCTCCAGGCAACACAAGGAGTTCCTGCGCCTCCGAAGAAGACAGAAGAGGCAGAATAAGGAAGAAGACGTTACTCGTGAAAG
TCGTTTTAATTTTAGCGGTTATGGGATGGGTCACTGCCTCCAAGTGAAAGATGGAACAGCTGTCAAGGCCACACCTGCCAACCCACTCCC
ACAACCGCCAAAAGATGGAGATGCTATCAAGAAGAAGTTTGTGGACCGGGCAAAAAGGATTGACACGATATCTCGAGCTGCCTTCCCATT
GGCCTTCCTCATTTTCAACATCTTTTACTGGATCACATACAAGATCATTCGGCATGAAGATGTCCACAAGAAATAGATGTGCCCTACAGA
CCCTGGGACCTTCTTGCCTCAGTGTTGTGCTTGTAAATACACAGTGAAATTGTCTTTATATCACTTTGACAGAGGAGAAGATTGAGGGAG
GGGGGAGGGAGGGTCATGGGGGTGGGTTTCCTGGCACCTACATGAAAAAAAAGACAAGTTATATGGGTGATGAAGAAAACTGCACAAAAT
TAAGGGGTTGCAGAATCACGGGAGCATAATAATTCCCTTCCATAATCTTTAGCATTGTTCTTTCAGTCAGACATGATATGCGCAACATTC
AGACATGATATGCGCATCATTCAGACATGATATGCGGGGTCAAGTTCTTAAGGGCTGTTTGCCTTTTGGTCCTTTTGGTTTGGTTTGGCT
TTGACTAATTCTGGTACTGAAAAGTTAGCTATACACACACACACACACACACACACACACACACACACACACACACACACACACACACAC
AAACTTCAAAAATGCTTAACCATCTGACCATAGTGACTAGCCTATAGTGAGTCGAGGACCAAACTTTTTCAGGAAAATGCTGCCTCGTTT
TTAAAACAAGCCTCCTAAGCTATGTTCTTTACAATGTCTGTAATTAGTGTTTCACTTGAGAAAGCCTTTTGTGGGTCGTAAATTATTTCT
ACTTATCCAGTAAATAACAATGACAAAATAAACACCAATGACAGAAAAATTTCTACTTTACTGTCCATATAGGTGTGCATTTTAATATTT
TTCTTTCCAAGATAAAATTTTGAAACTTAAATTGTGTATTGTGTAATTAATTTGATAGTGTACCCTCTTAATAAATGCCCACTTTATTTT
ATATCCAAGTTAGTGCATTATATATATATTTTTGCTTTGGCTATATTTACACGTGACTTTAATCGCCCAACTGTGACTAGTCATTGCAGC
TACTCAGCTACAGTATTTATGGAGATGGTGTGTCCTGAACAGTGTAGCTCAGGTCAGCTTGAACTTTCCATTTCTGCTCTCATTGTAGGT
GTAACTACTAGTCCTAATGTCAACTGACCCATGATTTCTACTGTCAGTCAATATAAGTGAACATTGTTTTAAATATCCTTAACTAACTTA
AAGAATTTTAAAATTGTACTGTGATTTTCATAACCCGTTGCCTTTTTGGTACCAGAGCTACGTGGTTTGAATTCTGGCTACATGTTTTAA
GTAAGAAAAAAAAAGACGTATTTTTGCTTACTCAGATAAAAGACAACCTGTAAAAATATAATAATTAAATTTTACATGTGCTGTACAAGG

>73476_73476_9_REPS2-GLRA2_REPS2_chrX_17121902_ENST00000380064_GLRA2_chrX_14708832_ENST00000443437_length(amino acids)=512AA_BP=368
MCGAKRVGYFGPTQFYIALKLIAAAQSGLPVRIESIKCELPLPRFMMSKNDGEIRFGNPAELHGTKVQIPYLTTEKNSFKRMDDEDKQET
QSPTMSPLASPPSSPPHYQRVPLSHGYSKLRSSAEQMHPAPYEARQPLVQPEGSSSGGPGTKPLRHQASLIRSFSVERELQDNSSYPDEP
WRITEEQREYYVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIPELSYIWELSDADCDGALTLPEFCAAFHLIVARKNGYPLPEGLPPTLQ
PEYLQAAFPKPKWDCQLFDSYSESLPANQQPRDLNRMEKTSVKDMADLPVPNQDVTSDDKQALKSTINEALPKDVSEDPATKSGLLPPPP
ALPPRPCPSQVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQNKEEDVTRESRFNFSGYGMGHCLQVKDGTAVK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for REPS2-GLRA2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneREPS2chrX:17121902chrX:14708832ENST00000303843+1418561_660525.0660.0ASAP1
HgeneREPS2chrX:17121902chrX:14708832ENST00000357277+1418561_660526.0661.0ASAP1
HgeneREPS2chrX:17121902chrX:14708832ENST00000303843+1418514_660525.0660.0RALBP1
HgeneREPS2chrX:17121902chrX:14708832ENST00000357277+1418514_660526.0661.0RALBP1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for REPS2-GLRA2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for REPS2-GLRA2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource