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	Fusion Gene Summary
	Fusion Gene ORF analysis
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Fusion gene:RERE-ETS1 (FusionGDB2 ID:73494)

Fusion Gene Summary for RERE-ETS1

Fusion gene summary

Fusion gene information	Fusion gene name: RERE-ETS1
	Fusion gene ID: 73494
		Hgene	Tgene
	Gene symbol	RERE	ETS1
	Gene ID	473	2113
	Gene name	arginine-glutamic acid dipeptide repeats	ETS proto-oncogene 1, transcription factor
	Synonyms	ARG\|ARP\|ATN1L\|DNB1\|NEDBEH	ETS-1\|EWSR2\|c-ets-1\|p54
	Cytomap	1p36.23	11q24.3
	Type of gene	protein-coding	protein-coding
	Description	arginine-glutamic acid dipeptide repeats proteinarginine-glutamic acid dipeptide (RE) repeatsatrophin 2atrophin-1 like proteinatrophin-1 related protein	protein C-ets-1Avian erythroblastosis virus E26 (v-ets) oncogene homolog-1v-ets avian erythroblastosis virus E2 oncogene homolog 1v-ets avian erythroblastosis virus E26 oncogene homolog 1
	Modification date	20200313	20200322
	UniProtAcc	.	P14921
	Ensembl transtripts involved in fusion gene	ENST00000337907, ENST00000377464, ENST00000400907, ENST00000400908, ENST00000460659, ENST00000476556,	ENST00000319397, ENST00000345075, ENST00000525404, ENST00000526145, ENST00000531611, ENST00000535549, ENST00000392668,
Fusion gene scores	* DoF score	27 X 28 X 11=8316	8 X 6 X 3=144
	# samples	43	8
	** MAII score	log2(43/8316*10)=-4.27348119326891 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/144*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: RERE [Title/Abstract] AND ETS1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	RERE(8525985)-ETS1(128360471), # samples:1
Anticipated loss of major functional domain due to fusion event.	RERE-ETS1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. RERE-ETS1 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	ETS1	GO:0030578	PML body organization	11909962\|15247905
Tgene	ETS1	GO:0045648	positive regulation of erythrocyte differentiation	8620536
Tgene	ETS1	GO:0045893	positive regulation of transcription, DNA-templated	11909962
Tgene	ETS1	GO:0045944	positive regulation of transcription by RNA polymerase II	15001984\|15247905
Tgene	ETS1	GO:0050729	positive regulation of inflammatory response	21310411
Tgene	ETS1	GO:0061614	pri-miRNA transcription by RNA polymerase II	21711453

Fusion gene breakpoints across RERE (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ETS1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-HU-A4GJ-01A	RERE	chr1	8525985	-	ETS1	chr11	128360471	-

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Fusion Gene ORF analysis for RERE-ETS1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000337907	ENST00000319397	RERE	chr1	8525985	-	ETS1	chr11	128360471	-
5CDS-intron	ENST00000337907	ENST00000345075	RERE	chr1	8525985	-	ETS1	chr11	128360471	-
5CDS-intron	ENST00000337907	ENST00000525404	RERE	chr1	8525985	-	ETS1	chr11	128360471	-
5CDS-intron	ENST00000337907	ENST00000526145	RERE	chr1	8525985	-	ETS1	chr11	128360471	-
5CDS-intron	ENST00000337907	ENST00000531611	RERE	chr1	8525985	-	ETS1	chr11	128360471	-
5CDS-intron	ENST00000337907	ENST00000535549	RERE	chr1	8525985	-	ETS1	chr11	128360471	-
5CDS-intron	ENST00000377464	ENST00000319397	RERE	chr1	8525985	-	ETS1	chr11	128360471	-
5CDS-intron	ENST00000377464	ENST00000345075	RERE	chr1	8525985	-	ETS1	chr11	128360471	-
5CDS-intron	ENST00000377464	ENST00000525404	RERE	chr1	8525985	-	ETS1	chr11	128360471	-
5CDS-intron	ENST00000377464	ENST00000526145	RERE	chr1	8525985	-	ETS1	chr11	128360471	-
5CDS-intron	ENST00000377464	ENST00000531611	RERE	chr1	8525985	-	ETS1	chr11	128360471	-
5CDS-intron	ENST00000377464	ENST00000535549	RERE	chr1	8525985	-	ETS1	chr11	128360471	-
5CDS-intron	ENST00000400907	ENST00000319397	RERE	chr1	8525985	-	ETS1	chr11	128360471	-
5CDS-intron	ENST00000400907	ENST00000345075	RERE	chr1	8525985	-	ETS1	chr11	128360471	-
5CDS-intron	ENST00000400907	ENST00000525404	RERE	chr1	8525985	-	ETS1	chr11	128360471	-
5CDS-intron	ENST00000400907	ENST00000526145	RERE	chr1	8525985	-	ETS1	chr11	128360471	-
5CDS-intron	ENST00000400907	ENST00000531611	RERE	chr1	8525985	-	ETS1	chr11	128360471	-
5CDS-intron	ENST00000400907	ENST00000535549	RERE	chr1	8525985	-	ETS1	chr11	128360471	-
5CDS-intron	ENST00000400908	ENST00000319397	RERE	chr1	8525985	-	ETS1	chr11	128360471	-
5CDS-intron	ENST00000400908	ENST00000345075	RERE	chr1	8525985	-	ETS1	chr11	128360471	-
5CDS-intron	ENST00000400908	ENST00000525404	RERE	chr1	8525985	-	ETS1	chr11	128360471	-
5CDS-intron	ENST00000400908	ENST00000526145	RERE	chr1	8525985	-	ETS1	chr11	128360471	-
5CDS-intron	ENST00000400908	ENST00000531611	RERE	chr1	8525985	-	ETS1	chr11	128360471	-
5CDS-intron	ENST00000400908	ENST00000535549	RERE	chr1	8525985	-	ETS1	chr11	128360471	-
Frame-shift	ENST00000337907	ENST00000392668	RERE	chr1	8525985	-	ETS1	chr11	128360471	-
Frame-shift	ENST00000377464	ENST00000392668	RERE	chr1	8525985	-	ETS1	chr11	128360471	-
Frame-shift	ENST00000400907	ENST00000392668	RERE	chr1	8525985	-	ETS1	chr11	128360471	-
In-frame	ENST00000400908	ENST00000392668	RERE	chr1	8525985	-	ETS1	chr11	128360471	-
intron-3CDS	ENST00000460659	ENST00000392668	RERE	chr1	8525985	-	ETS1	chr11	128360471	-
intron-3CDS	ENST00000476556	ENST00000392668	RERE	chr1	8525985	-	ETS1	chr11	128360471	-
intron-intron	ENST00000460659	ENST00000319397	RERE	chr1	8525985	-	ETS1	chr11	128360471	-
intron-intron	ENST00000460659	ENST00000345075	RERE	chr1	8525985	-	ETS1	chr11	128360471	-
intron-intron	ENST00000460659	ENST00000525404	RERE	chr1	8525985	-	ETS1	chr11	128360471	-
intron-intron	ENST00000460659	ENST00000526145	RERE	chr1	8525985	-	ETS1	chr11	128360471	-
intron-intron	ENST00000460659	ENST00000531611	RERE	chr1	8525985	-	ETS1	chr11	128360471	-
intron-intron	ENST00000460659	ENST00000535549	RERE	chr1	8525985	-	ETS1	chr11	128360471	-
intron-intron	ENST00000476556	ENST00000319397	RERE	chr1	8525985	-	ETS1	chr11	128360471	-
intron-intron	ENST00000476556	ENST00000345075	RERE	chr1	8525985	-	ETS1	chr11	128360471	-
intron-intron	ENST00000476556	ENST00000525404	RERE	chr1	8525985	-	ETS1	chr11	128360471	-
intron-intron	ENST00000476556	ENST00000526145	RERE	chr1	8525985	-	ETS1	chr11	128360471	-
intron-intron	ENST00000476556	ENST00000531611	RERE	chr1	8525985	-	ETS1	chr11	128360471	-
intron-intron	ENST00000476556	ENST00000535549	RERE	chr1	8525985	-	ETS1	chr11	128360471	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000400908

RERE

chr1

8525985

ENST00000392668

ETS1

chr11

128360471

6671

1831

526

1860

444

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000400908	ENST00000392668	RERE	chr1	8525985	-	ETS1	chr11	128360471	-	0.000183344	0.9998167

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Fusion Genomic Features for RERE-ETS1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RERE-ETS1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:8525985/chr11:128360471)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	ETS1 P14921
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion. {ECO:0000269\|PubMed:10698492, ECO:0000269\|PubMed:11909962, ECO:0000269\|PubMed:15247905, ECO:0000269\|PubMed:15592518}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RERE

chr1:8525985

chr11:128360471

ENST00000337907

103_283

401

1567.0

Domain

BAH

Hgene

RERE

chr1:8525985

chr11:128360471

ENST00000337907

284_387

401

1567.0

Domain

ELM2

Hgene

RERE

chr1:8525985

chr11:128360471

ENST00000400908

103_283

401

1567.0

Domain

BAH

Hgene

RERE

chr1:8525985

chr11:128360471

ENST00000400908

284_387

401

1567.0

Domain

ELM2

Tgene

ETS1

chr1:8525985

chr11:128360471

ENST00000319397

335_415

442.0

DNA binding

ETS

Tgene

ETS1

chr1:8525985

chr11:128360471

ENST00000345075

335_415

355.0

DNA binding

ETS

Tgene

ETS1

chr1:8525985

chr11:128360471

ENST00000392668

335_415

486.0

DNA binding

ETS

Tgene

ETS1

chr1:8525985

chr11:128360471

ENST00000526145

335_415

355.0

DNA binding

ETS

Tgene

ETS1

chr1:8525985

chr11:128360471

ENST00000535549

335_415

226.0

DNA binding

ETS

Tgene

ETS1

chr1:8525985

chr11:128360471

ENST00000319397

51_136

442.0

Domain

PNT

Tgene

ETS1

chr1:8525985

chr11:128360471

ENST00000345075

51_136

355.0

Domain

PNT

Tgene

ETS1

chr1:8525985

chr11:128360471

ENST00000526145

51_136

355.0

Domain

PNT

Tgene

ETS1

chr1:8525985

chr11:128360471

ENST00000535549

51_136

226.0

Domain

PNT

Tgene

ETS1

chr1:8525985

chr11:128360471

ENST00000319397

130_243

442.0

Region

Note=Activation domain%3B required for transcription activation

Tgene

ETS1

chr1:8525985

chr11:128360471

ENST00000345075

130_243

355.0

Region

Note=Activation domain%3B required for transcription activation

Tgene

ETS1

chr1:8525985

chr11:128360471

ENST00000392668

130_243

486.0

Region

Note=Activation domain%3B required for transcription activation

Tgene

ETS1

chr1:8525985

chr11:128360471

ENST00000526145

130_243

355.0

Region

Note=Activation domain%3B required for transcription activation

Tgene

ETS1

chr1:8525985

chr11:128360471

ENST00000535549

130_243

226.0

Region

Note=Activation domain%3B required for transcription activation

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RERE

chr1:8525985

chr11:128360471

ENST00000337907

1156_1211

401

1567.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

RERE

chr1:8525985

chr11:128360471

ENST00000400908

1156_1211

401

1567.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

RERE

chr1:8525985

chr11:128360471

ENST00000476556

1156_1211

1013.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

RERE

chr1:8525985

chr11:128360471

ENST00000337907

1179_1204

401

1567.0

Compositional bias

Note=Arg/Glu-rich (mixed charge)

Hgene

RERE

chr1:8525985

chr11:128360471

ENST00000337907

1300_1322

401

1567.0

Compositional bias

Note=Arg/Glu-rich (mixed charge)

Hgene

RERE

chr1:8525985

chr11:128360471

ENST00000337907

1425_1445

401

1567.0

Compositional bias

Note=His-rich

Hgene

RERE

chr1:8525985

chr11:128360471

ENST00000337907

1451_1510

401

1567.0

Compositional bias

Note=Pro-rich

Hgene

RERE

chr1:8525985

chr11:128360471

ENST00000337907

738_1118

401

1567.0

Compositional bias

Note=Pro-rich

Hgene

RERE

chr1:8525985

chr11:128360471

ENST00000400908

1179_1204

401

1567.0

Compositional bias

Note=Arg/Glu-rich (mixed charge)

Hgene

RERE

chr1:8525985

chr11:128360471

ENST00000400908

1300_1322

401

1567.0

Compositional bias

Note=Arg/Glu-rich (mixed charge)

Hgene

RERE

chr1:8525985

chr11:128360471

ENST00000400908

1425_1445

401

1567.0

Compositional bias

Note=His-rich

Hgene

RERE

chr1:8525985

chr11:128360471

ENST00000400908

1451_1510

401

1567.0

Compositional bias

Note=Pro-rich

Hgene

RERE

chr1:8525985

chr11:128360471

ENST00000400908

738_1118

401

1567.0

Compositional bias

Note=Pro-rich

Hgene

RERE

chr1:8525985

chr11:128360471

ENST00000476556

1179_1204

1013.0

Compositional bias

Note=Arg/Glu-rich (mixed charge)

Hgene

RERE

chr1:8525985

chr11:128360471

ENST00000476556

1300_1322

1013.0

Compositional bias

Note=Arg/Glu-rich (mixed charge)

Hgene

RERE

chr1:8525985

chr11:128360471

ENST00000476556

1425_1445

1013.0

Compositional bias

Note=His-rich

Hgene

RERE

chr1:8525985

chr11:128360471

ENST00000476556

1451_1510

1013.0

Compositional bias

Note=Pro-rich

Hgene

RERE

chr1:8525985

chr11:128360471

ENST00000476556

738_1118

1013.0

Compositional bias

Note=Pro-rich

Hgene

RERE

chr1:8525985

chr11:128360471

ENST00000337907

391_443

401

1567.0

Domain

SANT

Hgene

RERE

chr1:8525985

chr11:128360471

ENST00000400908

391_443

401

1567.0

Domain

SANT

Hgene

RERE

chr1:8525985

chr11:128360471

ENST00000476556

103_283

1013.0

Domain

BAH

Hgene

RERE

chr1:8525985

chr11:128360471

ENST00000476556

284_387

1013.0

Domain

ELM2

Hgene

RERE

chr1:8525985

chr11:128360471

ENST00000476556

391_443

1013.0

Domain

SANT

Hgene

RERE

chr1:8525985

chr11:128360471

ENST00000337907

507_532

401

1567.0

Zinc finger

Note=GATA-type

Hgene

RERE

chr1:8525985

chr11:128360471

ENST00000400908

507_532

401

1567.0

Zinc finger

Note=GATA-type

Hgene

RERE

chr1:8525985

chr11:128360471

ENST00000476556

507_532

1013.0

Zinc finger

Note=GATA-type

Tgene

ETS1

chr1:8525985

chr11:128360471

ENST00000392668

51_136

486.0

Domain

PNT

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Fusion Gene Sequence for RERE-ETS1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>73494_73494_1_RERE-ETS1_RERE_chr1_8525985_ENST00000400908_ETS1_chr11_128360471_ENST00000392668_length(transcript)=6671nt_BP=1831nt
CACAGACGCTCGCGAGCAACCCTCCGCGCTCCGGAGCCTCCTCAGCCTCCCGCACACCCCGAGACGCTCGCCCCGCTGGGCCTCGGTCCC
CGCCTCCTCCCCCGTCCTTTTCCCCTCTCTCGCTCCCCACATTGTCTCTGCCTCATTTTCTCTCCTAGTTGAGGATTAAAAAAAAAAAAA
AATCACCATCATCCTCAGGGAGCCCCCTCGCCCTCGGAAAACAAAACCAGACATGATCCTGGGCTCCTGCTTCTGAAAGATCTGCCCGAC
CGAGGAGGAGGGAGCCTAGGTTCAAGTCGCAGGAAAGGTCACGGCAGGGAAGCCCCCTCAGCCCCTCCGCGTCGCCTCCCCGCGGGCCGC
CCCTCTCGGCCCTGCGCCCCGCGGCCCCGCAGCCTCCGCGCGGCCTCCCGCCCCATCCCCGCCACTTTCCCCGGAGCTGGGCCGCGAACA
CCTCACTATTGATGGTGTAGCGCTTTAGGGGAAGCATTTTTGAAACGTTGGGGTTGTTGGAGTGGTTGGATTTTCCCTGGAATTGAGTGA
GAAATTCAGAAGACTGAAGCCCAGGCTTACTGTCTACCTTTCACGGAGGCCTAGCCGTGAGAGGACAGAAGAAGGCACGTGGCGAATCAT
GACAGCGGACAAAGACAAAGACAAAGACAAAGAGAAGGACCGGGACCGAGACCGGGACCGAGAGAGAGAGAAAAGAGACAAAGCAAGAGA
GAGTGAGAATTCAAGGCCACGCCGGAGCTGTACCTTGGAAGGAGGAGCCAAAAATTATGCTGAGAGTGATCACAGTGAAGACGAGGACAA
TGACAACAATAGTGCCACCGCAGAGGAGTCCACGAAGAAGAATAAGAAGAAACCACCGAAAAAAAAGTCTCGTTATGAAAGGACAGATAC
CGGTGAGATAACATCCTACATCACTGAAGATGATGTGGTCTACAGACCAGGAGACTGTGTGTATATCGAGAGTCGGAGGCCAAACACACC
GTATTTCATCTGTAGCATTCAAGACTTCAAACTGGTCCACAACTCCCAGGCCTGTTGCAGATCTCCAACTCCTGCTTTGTGTGACCCCCC
AGCATGCTCTCTGCCGGTGGCATCACAGCCACCACAGCATCTTTCTGAAGCCGGGAGAGGGCCTGTAGGGAGTAAGAGGGACCATCTCCT
CATGAACGTCAAATGGTACTACCGTCAATCTGAGGTTCCAGATTCTGTGTATCAGCATTTGGTTCAGGATCGACATAATGAAAATGACTC
TGGAAGAGAACTTGTCATTACAGACCCAGTTATCAAGAACCGAGAGCTCTTCATTTCTGATTACGTTGACACTTACCATGCTGCTGCCCT
TAGAGGGAAGTGTAACATCTCCCATTTTTCTGACATATTTGCTGCTAGAGAGTTTAAAGCCCGAGTGGATTCATTTTTCTACATATTAGG
ATATAACCCTGAGACAAGGAGGCTGAACAGTACCCAGGGGGAGATTCGTGTCGGTCCTAGTCATCAGGCCAAACTTCCAGATCTGCAACC
ATTTCCTTCTCCAGATGGTGATACAGTGACCCAACATGAGGAACTGGTCTGGATGCCTGGAGTTAACGACTGTGACCTCCTTATGTACTT
GAGGGCAGCAAGGAGCATGGCGGCATTTGCAGGAATGTGTGATGGAGGCTCTACAGAGGACGGCTGTGTCGCAGCCTCTCGGGATGACAC
CACTCTGAATGCACTGAACACACTGCATGAAAGCGGTTACGATGCTGGCAAAGCCCTGCAGCGCCTGGTGAAGAAGCCTGTGCCCAAGCT
CATCGAGAAGTGCTGGACCGAGGACGAAGTGATATGGAATGTGCAGATGTCCCACTATTAACTCCAAGCAGCAAAGAAATGATGTCTCAA
GCATTAAAAGCTACTTTCAGTGGTTTCACTAAAGAACAGCAACGACTGGGGATCCCAAAAGACCCCCGGCAGTGGACAGAAACCCATGTT
CGGGACTGGGTGATGTGGGCTGTGAATGAATTCAGCCTGAAAGGTGTAGACTTCCAGAAGTTCTGTATGAATGGAGCAGCCCTCTGCGCC
CTGGGTAAAGACTGCTTTCTCGAGCTGGCCCCAGACTTTGTTGGGGACATCTTATGGGAACATCTAGAGATCCTGCAGAAAGAGGATGTG
AAACCATATCAAGTTAATGGAGTCAACCCAGCCTATCCAGAATCCCGCTATACCTCGGATTACTTCATTAGCTATGGTATTGAGCATGCC
CAGTGTGTTCCACCATCGGAGTTCTCAGAGCCCAGCTTCATCACAGAGTCCTATCAGACGCTCCATCCCATCAGCTCGGAAGAGCTCCTC
TCCCTCAAGTATGAGAATGACTACCCCTCGGTCATTCTCCGAGACCCTCTCCAGACAGACACCTTGCAGAATGACTACTTTGCTATCAAA
CAAGAAGTCGTCACCCCAGACAACATGTGCATGGGGAGGACCAGTCGTGGTAAACTCGGGGGCCAGGACTCTTTTGAAAGCATAGAGAGC
TACGATAGTTGTGATCGCCTCACCCAGTCCTGGAGCAGCCAGTCATCTTTCAACAGCCTGCAGCGTGTTCCCTCCTATGACAGCTTCGAC
TCAGAGGACTATCCGGCTGCCCTGCCCAACCACAAGCCCAAGGGCACCTTCAAGGACTATGTGCGGGACCGTGCTGACCTCAATAAGGAC
AAGCCTGTCATTCCTGCTGCTGCCCTAGCTGGCTACACAGGCAGTGGACCAATCCAGCTATGGCAGTTTCTTCTGGAATTACTCACTGAT
AAATCCTGTCAGTCTTTTATCAGCTGGACAGGAGATGGCTGGGAATTCAAACTTTCTGACCCAGATGAGGTGGCCAGGAGATGGGGAAAG
AGGAAAAACAAACCTAAGATGAATTATGAGAAACTGAGCCGTGGCCTACGCTACTATTACGACAAAAACATCATCCACAAGACAGCGGGG
AAACGCTACGTGTACCGCTTTGTGTGTGACCTGCAGAGCCTGCTGGGGTACACCCCTGAGGAGCTGCACGCCATGCTGGACGTCAAGCCA
GATGCCGACGAGTGATGGCACTGAAGGGGCTGGGGAAACCCTGCTGAGACCTTCCAAGGACAGCCGTGTTGGTTGGACTCTGAATTTTGA
ATTGTTATTCTATTTTTTATTTTCCAGAACTCATTTTTTACCTTCAGGGGTGGGAGCTAAGTCAGTTGCAGCTGTAATCAATTGTGCGCA
GTTGGGAAAGGAAAGCCAGGACTTGTGGGGTGGGTGGGACCAGAAATTCTTGAGCAAATTTTCAGGAGAGGGAGAAGGGCCTTCTCAGAA
GCTTGAAGGCTCTGGCTTAACAGAGAAAGAGACTAATGTGTCCAATCATTTTTAAAAATCATCCATGAAAAAGTGTCTTGAGTTGTGGAC
CCATTAGCAAGTGACATTGTCACATCAGAACTCATGAAACTGATGTAAGGCAATTAATTTGCTTCTGTTTTTAGGTCTGGGAGGGCAAAA
AAGAGGTGGGTGGGATGAAACATGTTTTGGGGGGGGATGCACTGAAAATCTGAGAACTATTTACCTATCACTCTAGTTTTGAAGCAAAGA
TGGACTTCAGTGGGGAGGGGCCAAAACCGTTGTTGTGTTAAAATTTATTTTATTAAATTTTGTGCCAGTATTTTTTTTCTTAAAAATCGT
CTTAAGCTCTAAGGTGGTCTCAGTATTGCAATATCATGTAAGTTTGTTTTTATTTGCCGGCTGAGGATTCTGTCACAATGAAAGAAAACT
GTTTATATAGACCCCATTGGAAAAGCAAAACGCTCTCACTGAGATCAGGGATCCCAAATTCATGGGACTTATATAAGAAGGACAATTAAT
GCTGATTTGGGTACAGGGGAATTATGTGTGTGAATGTCATCTACAATTAAAAAAAATTAGCACATCCCTTTACTTACTTGTTATCAGTGG
ATTCTCGGGGTTTGGACTTAATGTTGAGCTAAGAAGCATTAAGTCTTTGAACTGAATGTATTTTGCATCCCTGGTTTTGGACGACAGTAA
ACGTAGGAGCACTGTTGAAGTCCTGGAAGGGAGATCGAAGGAGGAAGATTGACTTGGTTCTTTCTTAGTCCTATATCTGTAGCATAGATG
ACTTGGAATAAAAGCTGTATGCATGGGCATTACCCCTCAGGTCCTAAGAAATAAGTCCTGAATGCATGTCGTTCCAAACTAACACTCTGT
AATTTTTCTTTTATGTCTTATTTTCCAAGAGTCCTCCATTTTTTGCACCCCCTCACCGCCAACTCTGTTATTCAGTAGAGAGAAGTGTAC
GGCTTTCTGATTGGTGAGTGAAAAAGTAACTTGAGACACGACCTAAGTTGAAGAGTTTAGACTTGCTGAGTTTTAGAAGTGATGGAAATT
AAGAGAGCATTTCAATAAAATGTGACTTGGCTGTCTTTGGAAGAGAAGTGCAAGGCTTTCCTTTGAAGAATTTAAATTAGTCCGGTAGGA
TGTCAGGTGAGACTGTGTATGCAAAATGAATGGCACAGGTGATGCCAGGGCCTCTTGCTTGGGTCTGATGTCTTGGCACAGGGTAAGTGA
AGGTTAATTCCAGAAGAGAGGAATGACTTGAAGGCAAAGGAAACTAAGGAAGGAGGTTCAGTGAGGAAAATAAGGTTGTCCATGAGATTT
GAATAGATTTTTAGTTCCCCCAAGGTTTAAATACAAACATAGTCAAGCAAGGTAGTCATCTTTCTGCTGGTTGTGAGGGGGAATCTGAAA
ATGGAGTTTTAGAGGAAAAGTCAACATCTAACTAGTGAGGAAAAGTGCCTAATACAATTAGAATCTCCCTCACTCTATAGTTGCCCAGTT
GAAAGGATAAGGAGGAGGGGTGGCTTTTATGGACTTCCATGAGAGAAGGAAAGAAATATTTCAGGTAAGCTTCTCAGGGCTGGCCCTTTT
TGGGATTTGGATGAGAAATTGGAAGTACTAACTACTTTCTAGCATATCTTTAAGAAAATTGATTGTTATTTACTCCCAGATCCTCTTGCA
GACCCAGAATTATCAGGAACATAGCTCTGTGATTCATGAGTGTCCCCATACTGATGAATTGGAGCATCCATATGGAAAGCAAAGGCAGAA
TTATCCCAGCTGTATTATTTTGATCTTTTGGATGCAGGTGCCTTAATGAAGCTCTCAAAATATTTTAGGAGCTGCTCAGGGAGTGTTGGG
TGGAACTGTTTGGACTACATTGTTTTCTCTTAGATTATGTGATTTTTGTTGGGCACTGGCAAAAGGTGTGTGTGTGAATGTGTGCATGTG
TGTGAATGTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTTGCAGACATGCAAAACTGCAGCTGAAATAATACCT
TAGATTTCTAGGTAAGTCTTTCCACATTTCAATAATGGGTAAGAGTAGAACCAGGGCCGGGTATCAATTATTGCTTGCTGTTTGCAACCA
GGCATAAAATCACTTTCTCAAATCATCCACCGTTCCTATTAAATTTATGCCGGAAACTCTCCTTCTGTGAGTATAACTCCTGCAGTTCCT
ATAGCAGATAAGATATAAGAAAGTGCCTCCTAGTGCTCCTCCGCCCGCTTGTTTGCTAAAATTCCCTTTCTCTCTAAGTCCACCATTTTC
AAGATTTGTAGATAGTGTATTAGTTAAGACAGCTTTGTCGATCTGGCCAGATGTTTTTTCTCCTTTGTCCAAAGGCCAGAGACCATCCCA
GGAAGAGTGGTGGGTGGTTTATACACTGGAAATGTTGCGTTTATGCTTTTTAAAAACACACGTTAACTTCAGAGGAAGGATGGGCAAATC
TGGTCTAGCTGGGTGAAACCCTTATTTTCCCAGAGATGCCTTAACCTTTGTTGGTTTTGGCTTTAGGGTTCAGAGTCACTTTTGTTCCCT
TCTCCATTCTGGAGAGGGACTTCCCCTACATAGAGCCCTGATTTTTGTGGCTGTGGGGATTGGAGGTAGCATTCAAAGATCAGATGTGCT
TTTCCTCACTTTGGAGATGAACACTCTGGGTTTTACAGCATTAACCTGCCTAACCTTCATGGTGAGAAATACACCATCTCTCTTCTAGTC
ATGCTGTGCATGCCGCTTACTCTGTTGGGGTCTATATAAATTTGTTGAACTCTTACCTACATTCCAAAGAAGTTTCAAGGAACCATAAAT
ATATGTATACATATACATATATAAAATATATATATTAAAATAAAATTATCAGGAATACTGCCTCAGTTATTGAACTTTTTTTTTTAAGAA
TACTTTTTTTTTAAGCTGAGAAGTATAGGGATGAAAAAGATGTTATATTGTGTTTGACTATTTTCCAACTTGTATTTTCATATAATTTAT
ATTTTTTAAAAGCTGAAAATTTAGAAGCAAGATGAAAAAAAGGAAAAGCAGGTGCTTTTTAAAAATCAGAACTGAGGTAGCTTAGAGATG
TAGCGATGTAAGTGTCGATGTTTTTTTAAAAAAAAATGCAAAAAAATTCTTATGGCGGAGTTTTTTGTTTGTTTATTTTAGTAGCTGATG
CTGGCACATCATTTTGCTGGAGAGTTTTTTATATACTGTAGCCTGATTTCATATTGTATTTTAAACTGTGTGAAATTAAAAACAAAGAAT

>73494_73494_1_RERE-ETS1_RERE_chr1_8525985_ENST00000400908_ETS1_chr11_128360471_ENST00000392668_length(amino acids)=444AA_BP=
MELSEKFRRLKPRLTVYLSRRPSRERTEEGTWRIMTADKDKDKDKEKDRDRDRDREREKRDKARESENSRPRRSCTLEGGAKNYAESDHS
EDEDNDNNSATAEESTKKNKKKPPKKKSRYERTDTGEITSYITEDDVVYRPGDCVYIESRRPNTPYFICSIQDFKLVHNSQACCRSPTPA
LCDPPACSLPVASQPPQHLSEAGRGPVGSKRDHLLMNVKWYYRQSEVPDSVYQHLVQDRHNENDSGRELVITDPVIKNRELFISDYVDTY
HAAALRGKCNISHFSDIFAAREFKARVDSFFYILGYNPETRRLNSTQGEIRVGPSHQAKLPDLQPFPSPDGDTVTQHEELVWMPGVNDCD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RERE-ETS1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for RERE-ETS1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for RERE-ETS1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source