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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RERE-MFSD2A (FusionGDB2 ID:73503)

Fusion Gene Summary for RERE-MFSD2A

check button Fusion gene summary
Fusion gene informationFusion gene name: RERE-MFSD2A
Fusion gene ID: 73503
HgeneTgene
Gene symbol

RERE

MFSD2A

Gene ID

473

84879

Gene namearginine-glutamic acid dipeptide repeatsmajor facilitator superfamily domain containing 2A
SynonymsARG|ARP|ATN1L|DNB1|NEDBEHMCPH15|MFSD2|NLS1
Cytomap

1p36.23

1p34.2

Type of geneprotein-codingprotein-coding
Descriptionarginine-glutamic acid dipeptide repeats proteinarginine-glutamic acid dipeptide (RE) repeatsatrophin 2atrophin-1 like proteinatrophin-1 related proteinsodium-dependent lysophosphatidylcholine symporter 1major facilitator superfamily domain-containing protein 2Asodium-dependent LPC symporter 1
Modification date2020031320200313
UniProtAcc.

Q8NA29

Ensembl transtripts involved in fusion geneENST00000337907, ENST00000377464, 
ENST00000400907, ENST00000400908, 
ENST00000460659, ENST00000476556, 
ENST00000372809, ENST00000420632, 
ENST00000480630, ENST00000372811, 
Fusion gene scores* DoF score27 X 28 X 11=83168 X 8 X 3=192
# samples 438
** MAII scorelog2(43/8316*10)=-4.27348119326891
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/192*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RERE [Title/Abstract] AND MFSD2A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRERE(8482786)-MFSD2A(40422758), # samples:1
Anticipated loss of major functional domain due to fusion event.RERE-MFSD2A seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
RERE-MFSD2A seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
RERE-MFSD2A seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMFSD2A

GO:0051977

lysophospholipid transport

24828044


check buttonFusion gene breakpoints across RERE (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MFSD2A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-29-1778REREchr1

8482786

-MFSD2Achr1

40422758

+


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Fusion Gene ORF analysis for RERE-MFSD2A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000337907ENST00000372809REREchr1

8482786

-MFSD2Achr1

40422758

+
5CDS-intronENST00000337907ENST00000420632REREchr1

8482786

-MFSD2Achr1

40422758

+
5CDS-intronENST00000337907ENST00000480630REREchr1

8482786

-MFSD2Achr1

40422758

+
5CDS-intronENST00000377464ENST00000372809REREchr1

8482786

-MFSD2Achr1

40422758

+
5CDS-intronENST00000377464ENST00000420632REREchr1

8482786

-MFSD2Achr1

40422758

+
5CDS-intronENST00000377464ENST00000480630REREchr1

8482786

-MFSD2Achr1

40422758

+
5CDS-intronENST00000400907ENST00000372809REREchr1

8482786

-MFSD2Achr1

40422758

+
5CDS-intronENST00000400907ENST00000420632REREchr1

8482786

-MFSD2Achr1

40422758

+
5CDS-intronENST00000400907ENST00000480630REREchr1

8482786

-MFSD2Achr1

40422758

+
5CDS-intronENST00000400908ENST00000372809REREchr1

8482786

-MFSD2Achr1

40422758

+
5CDS-intronENST00000400908ENST00000420632REREchr1

8482786

-MFSD2Achr1

40422758

+
5CDS-intronENST00000400908ENST00000480630REREchr1

8482786

-MFSD2Achr1

40422758

+
5UTR-3CDSENST00000460659ENST00000372811REREchr1

8482786

-MFSD2Achr1

40422758

+
5UTR-3CDSENST00000476556ENST00000372811REREchr1

8482786

-MFSD2Achr1

40422758

+
5UTR-intronENST00000460659ENST00000372809REREchr1

8482786

-MFSD2Achr1

40422758

+
5UTR-intronENST00000460659ENST00000420632REREchr1

8482786

-MFSD2Achr1

40422758

+
5UTR-intronENST00000460659ENST00000480630REREchr1

8482786

-MFSD2Achr1

40422758

+
5UTR-intronENST00000476556ENST00000372809REREchr1

8482786

-MFSD2Achr1

40422758

+
5UTR-intronENST00000476556ENST00000420632REREchr1

8482786

-MFSD2Achr1

40422758

+
5UTR-intronENST00000476556ENST00000480630REREchr1

8482786

-MFSD2Achr1

40422758

+
Frame-shiftENST00000400908ENST00000372811REREchr1

8482786

-MFSD2Achr1

40422758

+
In-frameENST00000337907ENST00000372811REREchr1

8482786

-MFSD2Achr1

40422758

+
In-frameENST00000377464ENST00000372811REREchr1

8482786

-MFSD2Achr1

40422758

+
In-frameENST00000400907ENST00000372811REREchr1

8482786

-MFSD2Achr1

40422758

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000337907REREchr18482786-ENST00000372811MFSD2Achr140422758+381719195333418961
ENST00000377464REREchr18482786-ENST00000372811MFSD2Achr140422758+25336351552134659
ENST00000400907REREchr18482786-ENST00000372811MFSD2Achr140422758+32561358742857927

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000337907ENST00000372811REREchr18482786-MFSD2Achr140422758+0.0011242070.9988758
ENST00000377464ENST00000372811REREchr18482786-MFSD2Achr140422758+0.0036751170.99632484
ENST00000400907ENST00000372811REREchr18482786-MFSD2Achr140422758+0.0012484960.9987515

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Fusion Genomic Features for RERE-MFSD2A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
REREchr18482786-MFSD2Achr140422758+3.35E-081
REREchr18482786-MFSD2Achr140422758+3.35E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for RERE-MFSD2A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:8482786/chr1:40422758)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MFSD2A

Q8NA29

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function (PubMed:24828040). Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain (By similarity). Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain (PubMed:26005868). Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons (By similarity). Does not transport docosahexaenoic acid in unesterified fatty acid (By similarity). Specifically required for blood-brain barrier formation and function, probably by mediating lipid transport (By similarity). Not required for central nervous system vascular morphogenesis (By similarity). Acts as a transporter for tunicamycin, an inhibitor of asparagine-linked glycosylation (PubMed:21677192). In placenta, acts as a receptor for ERVFRD-1/syncytin-2 and is required for trophoblast fusion (PubMed:18988732, PubMed:23177091). {ECO:0000250|UniProtKB:Q9DA75, ECO:0000269|PubMed:18988732, ECO:0000269|PubMed:21677192, ECO:0000269|PubMed:23177091, ECO:0000269|PubMed:24828040, ECO:0000269|PubMed:26005868}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneREREchr1:8482786chr1:40422758ENST00000337907-1324103_2834281567.0DomainBAH
HgeneREREchr1:8482786chr1:40422758ENST00000337907-1324284_3874281567.0DomainELM2
HgeneREREchr1:8482786chr1:40422758ENST00000400908-1223103_2834281567.0DomainBAH
HgeneREREchr1:8482786chr1:40422758ENST00000400908-1223284_3874281567.0DomainELM2
TgeneMFSD2Achr1:8482786chr1:40422758ENST0000037280901435_3831544.0Compositional biasNote=Poly-Lys
TgeneMFSD2Achr1:8482786chr1:40422758ENST0000037281101435_3831531.0Compositional biasNote=Poly-Lys
TgeneMFSD2Achr1:8482786chr1:40422758ENST00000372809014102_12831544.0Topological domainExtracellular
TgeneMFSD2Achr1:8482786chr1:40422758ENST00000372809014150_16031544.0Topological domainCytoplasmic
TgeneMFSD2Achr1:8482786chr1:40422758ENST00000372809014182_25631544.0Topological domainExtracellular
TgeneMFSD2Achr1:8482786chr1:40422758ENST00000372809014278_31031544.0Topological domainCytoplasmic
TgeneMFSD2Achr1:8482786chr1:40422758ENST00000372809014332_34431544.0Topological domainExtracellular
TgeneMFSD2Achr1:8482786chr1:40422758ENST00000372809014366_37031544.0Topological domainCytoplasmic
TgeneMFSD2Achr1:8482786chr1:40422758ENST00000372809014392_39331544.0Topological domainExtracellular
TgeneMFSD2Achr1:8482786chr1:40422758ENST00000372809014415_43731544.0Topological domainCytoplasmic
TgeneMFSD2Achr1:8482786chr1:40422758ENST00000372809014459_48031544.0Topological domainExtracellular
TgeneMFSD2Achr1:8482786chr1:40422758ENST00000372809014502_54331544.0Topological domainCytoplasmic
TgeneMFSD2Achr1:8482786chr1:40422758ENST0000037280901468_8031544.0Topological domainCytoplasmic
TgeneMFSD2Achr1:8482786chr1:40422758ENST00000372811014102_12831531.0Topological domainExtracellular
TgeneMFSD2Achr1:8482786chr1:40422758ENST00000372811014150_16031531.0Topological domainCytoplasmic
TgeneMFSD2Achr1:8482786chr1:40422758ENST00000372811014182_25631531.0Topological domainExtracellular
TgeneMFSD2Achr1:8482786chr1:40422758ENST00000372811014278_31031531.0Topological domainCytoplasmic
TgeneMFSD2Achr1:8482786chr1:40422758ENST00000372811014332_34431531.0Topological domainExtracellular
TgeneMFSD2Achr1:8482786chr1:40422758ENST00000372811014366_37031531.0Topological domainCytoplasmic
TgeneMFSD2Achr1:8482786chr1:40422758ENST00000372811014392_39331531.0Topological domainExtracellular
TgeneMFSD2Achr1:8482786chr1:40422758ENST00000372811014415_43731531.0Topological domainCytoplasmic
TgeneMFSD2Achr1:8482786chr1:40422758ENST00000372811014459_48031531.0Topological domainExtracellular
TgeneMFSD2Achr1:8482786chr1:40422758ENST00000372811014502_54331531.0Topological domainCytoplasmic
TgeneMFSD2Achr1:8482786chr1:40422758ENST0000037281101468_8031531.0Topological domainCytoplasmic
TgeneMFSD2Achr1:8482786chr1:40422758ENST00000372809014129_14931544.0TransmembraneHelical
TgeneMFSD2Achr1:8482786chr1:40422758ENST00000372809014161_18131544.0TransmembraneHelical
TgeneMFSD2Achr1:8482786chr1:40422758ENST00000372809014257_27731544.0TransmembraneHelical
TgeneMFSD2Achr1:8482786chr1:40422758ENST00000372809014311_33131544.0TransmembraneHelical
TgeneMFSD2Achr1:8482786chr1:40422758ENST00000372809014345_36531544.0TransmembraneHelical
TgeneMFSD2Achr1:8482786chr1:40422758ENST00000372809014371_39131544.0TransmembraneHelical
TgeneMFSD2Achr1:8482786chr1:40422758ENST00000372809014394_41431544.0TransmembraneHelical
TgeneMFSD2Achr1:8482786chr1:40422758ENST00000372809014438_45831544.0TransmembraneHelical
TgeneMFSD2Achr1:8482786chr1:40422758ENST0000037280901447_6731544.0TransmembraneHelical
TgeneMFSD2Achr1:8482786chr1:40422758ENST00000372809014481_50131544.0TransmembraneHelical
TgeneMFSD2Achr1:8482786chr1:40422758ENST0000037280901481_10131544.0TransmembraneHelical
TgeneMFSD2Achr1:8482786chr1:40422758ENST00000372811014129_14931531.0TransmembraneHelical
TgeneMFSD2Achr1:8482786chr1:40422758ENST00000372811014161_18131531.0TransmembraneHelical
TgeneMFSD2Achr1:8482786chr1:40422758ENST00000372811014257_27731531.0TransmembraneHelical
TgeneMFSD2Achr1:8482786chr1:40422758ENST00000372811014311_33131531.0TransmembraneHelical
TgeneMFSD2Achr1:8482786chr1:40422758ENST00000372811014345_36531531.0TransmembraneHelical
TgeneMFSD2Achr1:8482786chr1:40422758ENST00000372811014371_39131531.0TransmembraneHelical
TgeneMFSD2Achr1:8482786chr1:40422758ENST00000372811014394_41431531.0TransmembraneHelical
TgeneMFSD2Achr1:8482786chr1:40422758ENST00000372811014438_45831531.0TransmembraneHelical
TgeneMFSD2Achr1:8482786chr1:40422758ENST0000037281101447_6731531.0TransmembraneHelical
TgeneMFSD2Achr1:8482786chr1:40422758ENST00000372811014481_50131531.0TransmembraneHelical
TgeneMFSD2Achr1:8482786chr1:40422758ENST0000037281101481_10131531.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneREREchr1:8482786chr1:40422758ENST00000337907-13241156_12114281567.0Coiled coilOntology_term=ECO:0000255
HgeneREREchr1:8482786chr1:40422758ENST00000400908-12231156_12114281567.0Coiled coilOntology_term=ECO:0000255
HgeneREREchr1:8482786chr1:40422758ENST00000476556-2131156_121101013.0Coiled coilOntology_term=ECO:0000255
HgeneREREchr1:8482786chr1:40422758ENST00000337907-13241179_12044281567.0Compositional biasNote=Arg/Glu-rich (mixed charge)
HgeneREREchr1:8482786chr1:40422758ENST00000337907-13241300_13224281567.0Compositional biasNote=Arg/Glu-rich (mixed charge)
HgeneREREchr1:8482786chr1:40422758ENST00000337907-13241425_14454281567.0Compositional biasNote=His-rich
HgeneREREchr1:8482786chr1:40422758ENST00000337907-13241451_15104281567.0Compositional biasNote=Pro-rich
HgeneREREchr1:8482786chr1:40422758ENST00000337907-1324738_11184281567.0Compositional biasNote=Pro-rich
HgeneREREchr1:8482786chr1:40422758ENST00000400908-12231179_12044281567.0Compositional biasNote=Arg/Glu-rich (mixed charge)
HgeneREREchr1:8482786chr1:40422758ENST00000400908-12231300_13224281567.0Compositional biasNote=Arg/Glu-rich (mixed charge)
HgeneREREchr1:8482786chr1:40422758ENST00000400908-12231425_14454281567.0Compositional biasNote=His-rich
HgeneREREchr1:8482786chr1:40422758ENST00000400908-12231451_15104281567.0Compositional biasNote=Pro-rich
HgeneREREchr1:8482786chr1:40422758ENST00000400908-1223738_11184281567.0Compositional biasNote=Pro-rich
HgeneREREchr1:8482786chr1:40422758ENST00000476556-2131179_120401013.0Compositional biasNote=Arg/Glu-rich (mixed charge)
HgeneREREchr1:8482786chr1:40422758ENST00000476556-2131300_132201013.0Compositional biasNote=Arg/Glu-rich (mixed charge)
HgeneREREchr1:8482786chr1:40422758ENST00000476556-2131425_144501013.0Compositional biasNote=His-rich
HgeneREREchr1:8482786chr1:40422758ENST00000476556-2131451_151001013.0Compositional biasNote=Pro-rich
HgeneREREchr1:8482786chr1:40422758ENST00000476556-213738_111801013.0Compositional biasNote=Pro-rich
HgeneREREchr1:8482786chr1:40422758ENST00000337907-1324391_4434281567.0DomainSANT
HgeneREREchr1:8482786chr1:40422758ENST00000400908-1223391_4434281567.0DomainSANT
HgeneREREchr1:8482786chr1:40422758ENST00000476556-213103_28301013.0DomainBAH
HgeneREREchr1:8482786chr1:40422758ENST00000476556-213284_38701013.0DomainELM2
HgeneREREchr1:8482786chr1:40422758ENST00000476556-213391_44301013.0DomainSANT
HgeneREREchr1:8482786chr1:40422758ENST00000337907-1324507_5324281567.0Zinc fingerNote=GATA-type
HgeneREREchr1:8482786chr1:40422758ENST00000400908-1223507_5324281567.0Zinc fingerNote=GATA-type
HgeneREREchr1:8482786chr1:40422758ENST00000476556-213507_53201013.0Zinc fingerNote=GATA-type
TgeneMFSD2Achr1:8482786chr1:40422758ENST000003728090141_4631544.0Topological domainExtracellular
TgeneMFSD2Achr1:8482786chr1:40422758ENST000003728110141_4631531.0Topological domainExtracellular


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Fusion Gene Sequence for RERE-MFSD2A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>73503_73503_1_RERE-MFSD2A_RERE_chr1_8482786_ENST00000337907_MFSD2A_chr1_40422758_ENST00000372811_length(transcript)=3817nt_BP=1919nt
AAAATCACCATCATCCTCAGGGAGCCCCCTCGCCCTCGGAAAACAAAACCAGACATGATCCTGGGCTCCTGCTTCTGAAAGATCTGCCCG
ACCGAGGAGGAGGGAGCCTAGGTTCAAGTCGCAGGAAAGGTCACGGCAGGGAAGCCCCCTCAGCCCCTCCGCGTCGCCTCCCCGCGGGCC
GCCCCTCTCGGCCCTGCGCCCCGCGGCCCCGCAGCCTCCGCGCGGCCTCCCGCCCCATCCCCGCCACTTTCCCCGGAGCTGGGCCGCGAA
CACCTCACTATTGATGGTGTAGCGCTTTAGGGGAAGGAGGTGATTGTCTAGGAGTAACTGTATGTGCGCTCAGCACCGGGTCACAACCAC
CGTGGGATCCACTTACAGAGAAGATTTGTGGAGAGCTTCAGCCTGTTTATGGTGTTACTGAGAAAGGAATTGTGGCCATTTGATATAATT
CTGGATGGAAGACCTCTTATTTGTATTACATTGAATTAGAGCATTTTTGAAACGTTGGGGTTGTTGGAGTGGTTGGATTTTCCCTGGAAT
TGAGTGAGAAATTCAGAAGACTGAAGCCCAGGCTTACTGTCTACCTTTCACGGAGGCCTAGCCGTGAGAGGACAGAAGAAGGCACGTGGC
GAATCATGACAGCGGACAAAGACAAAGACAAAGACAAAGAGAAGGACCGGGACCGAGACCGGGACCGAGAGAGAGAGAAAAGAGACAAAG
CAAGAGAGAGTGAGAATTCAAGGCCACGCCGGAGCTGTACCTTGGAAGGAGGAGCCAAAAATTATGCTGAGAGTGATCACAGTGAAGACG
AGGACAATGACAACAATAGTGCCACCGCAGAGGAGTCCACGAAGAAGAATAAGAAGAAACCACCGAAAAAAAAGTCTCGTTATGAAAGGA
CAGATACCGGTGAGATAACATCCTACATCACTGAAGATGATGTGGTCTACAGACCAGGAGACTGTGTGTATATCGAGAGTCGGAGGCCAA
ACACACCGTATTTCATCTGTAGCATTCAAGACTTCAAACTGGTCCACAACTCCCAGGCCTGTTGCAGATCTCCAACTCCTGCTTTGTGTG
ACCCCCCAGCATGCTCTCTGCCGGTGGCATCACAGCCACCACAGCATCTTTCTGAAGCCGGGAGAGGGCCTGTAGGGAGTAAGAGGGACC
ATCTCCTCATGAACGTCAAATGGTACTACCGTCAATCTGAGGTTCCAGATTCTGTGTATCAGCATTTGGTTCAGGATCGACATAATGAAA
ATGACTCTGGAAGAGAACTTGTCATTACAGACCCAGTTATCAAGAACCGAGAGCTCTTCATTTCTGATTACGTTGACACTTACCATGCTG
CTGCCCTTAGAGGGAAGTGTAACATCTCCCATTTTTCTGACATATTTGCTGCTAGAGAGTTTAAAGCCCGAGTGGATTCATTTTTCTACA
TATTAGGATATAACCCTGAGACAAGGAGGCTGAACAGTACCCAGGGGGAGATTCGTGTCGGTCCTAGTCATCAGGCCAAACTTCCAGATC
TGCAACCATTTCCTTCTCCAGATGGTGATACAGTGACCCAACATGAGGAACTGGTCTGGATGCCTGGAGTTAACGACTGTGACCTCCTTA
TGTACTTGAGGGCAGCAAGGAGCATGGCGGCATTTGCAGGAATGTGTGATGGAGGCTCTACAGAGGACGGCTGTGTCGCAGCCTCTCGGG
ATGACACCACTCTGAATGCACTGAACACACTGCATGAAAGCGGTTACGATGCTGGCAAAGCCCTGCAGCGCCTGGTGAAGAAGCCTGTGC
CCAAGCTCATCGAGAAGTGCTGGACCGAGGACGAAGTGAAACGCTTCGTTAAGGGACTCAGGCAGTACGGGAAGAACTTCTTCAGAATTA
GAAAGGAGCTGCTTCCCAATAAGGAAACAAAAGAACCGAAAAAGAAGAAACAACAGTTGTCTGTTTGCAACAAGCTTTGCTATGCACTTG
GGGGAGCCCCCTACCAGGTGACGGGCTGTGCCCTGGGTTTCTTCCTTCAGATCTACCTATTGGATGTGGCTCAGGTGGGCCCTTTCTCTG
CCTCCATCATCCTGTTTGTGGGCCGAGCCTGGGATGCCATCACAGACCCCCTGGTGGGCCTCTGCATCAGCAAATCCCCCTGGACCTGCC
TGGGTCGCCTTATGCCCTGGATCATCTTCTCCACGCCCCTGGCCGTCATTGCCTACTTCCTCATCTGGTTCGTGCCCGACTTCCCACACG
GCCAGACCTATTGGTACCTGCTTTTCTATTGCCTCTTTGAAACAATGGTCACGTGTTTCCATGTTCCCTACTCGGCTCTCACCATGTTCA
TCAGCACCGAGCAGACTGAGCGGGATTCTGCCACCGCCTATCGGATGACTGTGGAAGTGCTGGGCACAGTGCTGGGCACGGCGATCCAGG
GACAAATCGTGGGCCAAGCAGACACGCCTTGTTTCCAGGACCTCAATAGCTCTACAGTAGCTTCACAAAGTGCCAACCATACACATGGCA
CCACCTCACACAGGGAAACGCAAAAGGCATACCTGCTGGCAGCGGGGGTCATTGTCTGTATCTATATAATCTGTGCTGTCATCCTGATCC
TGGGCGTGCGGGAGCAGAGAGAACCCTATGAAGCCCAGCAGTCTGAGCCAATCGCCTACTTCCGGGGCCTACGGCTGGTCATGAGCCACG
GCCCATACATCAAACTTATTACTGGCTTCCTCTTCACCTCCTTGGCTTTCATGCTGGTGGAGGGGAACTTTGTCTTGTTTTGCACCTACA
CCTTGGGCTTCCGCAATGAATTCCAGAATCTACTCCTGGCCATCATGCTCTCGGCCACTTTAACCATTCCCATCTGGCAGTGGTTCTTGA
CCCGGTTTGGCAAGAAGACAGCTGTATATGTTGGGATCTCATCAGCAGTGCCATTTCTCATCTTGGTGGCCCTCATGGAGAGTAACCTCA
TCATTACATATGCGGTAGCTGTGGCAGCTGGCATCAGTGTGGCAGCTGCCTTCTTACTACCCTGGTCCATGCTGCCTGATGTCATTGACG
ACTTCCATCTGAAGCAGCCCCACTTCCATGGAACCGAGCCCATCTTCTTCTCCTTCTATGTCTTCTTCACCAAGTTTGCCTCTGGAGTGT
CACTGGGCATTTCTACCCTCAGTCTGGACTTTGCAGGGTACCAGACCCGTGGCTGCTCGCAGCCGGAACGTGTCAAGTTTACACTGAACA
TGCTCGTGACCATGGCTCCCATAGTTCTCATCCTGCTGGGCCTGCTGCTCTTCAAAATGTACCCCATTGATGAGGAGAGGCGGCGGCAGA
ATAAGAAGGCCCTGCAGGCACTGAGGGACGAGGCCAGCAGCTCTGGCTGCTCAGAAACAGACTCCACAGAGCTGGCTAGCATCCTCTAGG
GCCCGCCACGTTGCCCGAAGCCACCATGCAGAAGGCCACAGAAGGGATCAGGACCTGTCTGCCGGCTTGCTGAGCAGCTGGACTGCAGGT
GCTAGGAAGGGAACTGAAGACTCAAGGAGGTGGCCCAGGACACTTGCTGTGCTCACTGTGGGGCCGGCTGCTCTGTGGCCTCCTGCCTCC
CCTCTGCCTGCCTGTGGGGCCAAGCCCTGGGGCTGCCACTGTGAATATGCCAAGGACTGATCGGGCCTAGCCCGGAACACTAATGTAGAA
ACCTTTTTTTTTACAGAGCCTAATTAATAACTTAATGACTGTGTACATAGCAATGTGTGTGTATGTATATGTCTGTGAGCTATTAATGTT

>73503_73503_1_RERE-MFSD2A_RERE_chr1_8482786_ENST00000337907_MFSD2A_chr1_40422758_ENST00000372811_length(amino acids)=961AA_BP=462
MELSEKFRRLKPRLTVYLSRRPSRERTEEGTWRIMTADKDKDKDKEKDRDRDRDREREKRDKARESENSRPRRSCTLEGGAKNYAESDHS
EDEDNDNNSATAEESTKKNKKKPPKKKSRYERTDTGEITSYITEDDVVYRPGDCVYIESRRPNTPYFICSIQDFKLVHNSQACCRSPTPA
LCDPPACSLPVASQPPQHLSEAGRGPVGSKRDHLLMNVKWYYRQSEVPDSVYQHLVQDRHNENDSGRELVITDPVIKNRELFISDYVDTY
HAAALRGKCNISHFSDIFAAREFKARVDSFFYILGYNPETRRLNSTQGEIRVGPSHQAKLPDLQPFPSPDGDTVTQHEELVWMPGVNDCD
LLMYLRAARSMAAFAGMCDGGSTEDGCVAASRDDTTLNALNTLHESGYDAGKALQRLVKKPVPKLIEKCWTEDEVKRFVKGLRQYGKNFF
RIRKELLPNKETKEPKKKKQQLSVCNKLCYALGGAPYQVTGCALGFFLQIYLLDVAQVGPFSASIILFVGRAWDAITDPLVGLCISKSPW
TCLGRLMPWIIFSTPLAVIAYFLIWFVPDFPHGQTYWYLLFYCLFETMVTCFHVPYSALTMFISTEQTERDSATAYRMTVEVLGTVLGTA
IQGQIVGQADTPCFQDLNSSTVASQSANHTHGTTSHRETQKAYLLAAGVIVCIYIICAVILILGVREQREPYEAQQSEPIAYFRGLRLVM
SHGPYIKLITGFLFTSLAFMLVEGNFVLFCTYTLGFRNEFQNLLLAIMLSATLTIPIWQWFLTRFGKKTAVYVGISSAVPFLILVALMES
NLIITYAVAVAAGISVAAAFLLPWSMLPDVIDDFHLKQPHFHGTEPIFFSFYVFFTKFASGVSLGISTLSLDFAGYQTRGCSQPERVKFT

--------------------------------------------------------------
>73503_73503_2_RERE-MFSD2A_RERE_chr1_8482786_ENST00000377464_MFSD2A_chr1_40422758_ENST00000372811_length(transcript)=2533nt_BP=635nt
GGCTTAGGTCATAGCACAAGCTCAGTGAAAGCTCTATGAGGTCTCTGAGACTGCATGTGCCTCCATTTTGAGTTGTTAGTGTAGAAAAGG
GCAGAGTTTTAGCAGAAAGTAAAGGTTCAGGAATCCAGCTAGACTCACCAGAGCCCGTGTTAGTCATGGATGATCCATTCAGCCCCTGCA
GGAGGCTGAACAGTACCCAGGGGGAGATTCGTGTCGGTCCTAGTCATCAGGCCAAACTTCCAGATCTGCAACCATTTCCTTCTCCAGATG
GTGATACAGTGACCCAACATGAGGAACTGGTCTGGATGCCTGGAGTTAACGACTGTGACCTCCTTATGTACTTGAGGGCAGCAAGGAGCA
TGGCGGCATTTGCAGGAATGTGTGATGGAGGCTCTACAGAGGACGGCTGTGTCGCAGCCTCTCGGGATGACACCACTCTGAATGCACTGA
ACACACTGCATGAAAGCGGTTACGATGCTGGCAAAGCCCTGCAGCGCCTGGTGAAGAAGCCTGTGCCCAAGCTCATCGAGAAGTGCTGGA
CCGAGGACGAAGTGAAACGCTTCGTTAAGGGACTCAGGCAGTACGGGAAGAACTTCTTCAGAATTAGAAAGGAGCTGCTTCCCAATAAGG
AAACAAAAGAACCGAAAAAGAAGAAACAACAGTTGTCTGTTTGCAACAAGCTTTGCTATGCACTTGGGGGAGCCCCCTACCAGGTGACGG
GCTGTGCCCTGGGTTTCTTCCTTCAGATCTACCTATTGGATGTGGCTCAGGTGGGCCCTTTCTCTGCCTCCATCATCCTGTTTGTGGGCC
GAGCCTGGGATGCCATCACAGACCCCCTGGTGGGCCTCTGCATCAGCAAATCCCCCTGGACCTGCCTGGGTCGCCTTATGCCCTGGATCA
TCTTCTCCACGCCCCTGGCCGTCATTGCCTACTTCCTCATCTGGTTCGTGCCCGACTTCCCACACGGCCAGACCTATTGGTACCTGCTTT
TCTATTGCCTCTTTGAAACAATGGTCACGTGTTTCCATGTTCCCTACTCGGCTCTCACCATGTTCATCAGCACCGAGCAGACTGAGCGGG
ATTCTGCCACCGCCTATCGGATGACTGTGGAAGTGCTGGGCACAGTGCTGGGCACGGCGATCCAGGGACAAATCGTGGGCCAAGCAGACA
CGCCTTGTTTCCAGGACCTCAATAGCTCTACAGTAGCTTCACAAAGTGCCAACCATACACATGGCACCACCTCACACAGGGAAACGCAAA
AGGCATACCTGCTGGCAGCGGGGGTCATTGTCTGTATCTATATAATCTGTGCTGTCATCCTGATCCTGGGCGTGCGGGAGCAGAGAGAAC
CCTATGAAGCCCAGCAGTCTGAGCCAATCGCCTACTTCCGGGGCCTACGGCTGGTCATGAGCCACGGCCCATACATCAAACTTATTACTG
GCTTCCTCTTCACCTCCTTGGCTTTCATGCTGGTGGAGGGGAACTTTGTCTTGTTTTGCACCTACACCTTGGGCTTCCGCAATGAATTCC
AGAATCTACTCCTGGCCATCATGCTCTCGGCCACTTTAACCATTCCCATCTGGCAGTGGTTCTTGACCCGGTTTGGCAAGAAGACAGCTG
TATATGTTGGGATCTCATCAGCAGTGCCATTTCTCATCTTGGTGGCCCTCATGGAGAGTAACCTCATCATTACATATGCGGTAGCTGTGG
CAGCTGGCATCAGTGTGGCAGCTGCCTTCTTACTACCCTGGTCCATGCTGCCTGATGTCATTGACGACTTCCATCTGAAGCAGCCCCACT
TCCATGGAACCGAGCCCATCTTCTTCTCCTTCTATGTCTTCTTCACCAAGTTTGCCTCTGGAGTGTCACTGGGCATTTCTACCCTCAGTC
TGGACTTTGCAGGGTACCAGACCCGTGGCTGCTCGCAGCCGGAACGTGTCAAGTTTACACTGAACATGCTCGTGACCATGGCTCCCATAG
TTCTCATCCTGCTGGGCCTGCTGCTCTTCAAAATGTACCCCATTGATGAGGAGAGGCGGCGGCAGAATAAGAAGGCCCTGCAGGCACTGA
GGGACGAGGCCAGCAGCTCTGGCTGCTCAGAAACAGACTCCACAGAGCTGGCTAGCATCCTCTAGGGCCCGCCACGTTGCCCGAAGCCAC
CATGCAGAAGGCCACAGAAGGGATCAGGACCTGTCTGCCGGCTTGCTGAGCAGCTGGACTGCAGGTGCTAGGAAGGGAACTGAAGACTCA
AGGAGGTGGCCCAGGACACTTGCTGTGCTCACTGTGGGGCCGGCTGCTCTGTGGCCTCCTGCCTCCCCTCTGCCTGCCTGTGGGGCCAAG
CCCTGGGGCTGCCACTGTGAATATGCCAAGGACTGATCGGGCCTAGCCCGGAACACTAATGTAGAAACCTTTTTTTTTACAGAGCCTAAT
TAATAACTTAATGACTGTGTACATAGCAATGTGTGTGTATGTATATGTCTGTGAGCTATTAATGTTATTAATTTTCATAAAAGCTGGAAA

>73503_73503_2_RERE-MFSD2A_RERE_chr1_8482786_ENST00000377464_MFSD2A_chr1_40422758_ENST00000372811_length(amino acids)=659AA_BP=160
MDDPFSPCRRLNSTQGEIRVGPSHQAKLPDLQPFPSPDGDTVTQHEELVWMPGVNDCDLLMYLRAARSMAAFAGMCDGGSTEDGCVAASR
DDTTLNALNTLHESGYDAGKALQRLVKKPVPKLIEKCWTEDEVKRFVKGLRQYGKNFFRIRKELLPNKETKEPKKKKQQLSVCNKLCYAL
GGAPYQVTGCALGFFLQIYLLDVAQVGPFSASIILFVGRAWDAITDPLVGLCISKSPWTCLGRLMPWIIFSTPLAVIAYFLIWFVPDFPH
GQTYWYLLFYCLFETMVTCFHVPYSALTMFISTEQTERDSATAYRMTVEVLGTVLGTAIQGQIVGQADTPCFQDLNSSTVASQSANHTHG
TTSHRETQKAYLLAAGVIVCIYIICAVILILGVREQREPYEAQQSEPIAYFRGLRLVMSHGPYIKLITGFLFTSLAFMLVEGNFVLFCTY
TLGFRNEFQNLLLAIMLSATLTIPIWQWFLTRFGKKTAVYVGISSAVPFLILVALMESNLIITYAVAVAAGISVAAAFLLPWSMLPDVID
DFHLKQPHFHGTEPIFFSFYVFFTKFASGVSLGISTLSLDFAGYQTRGCSQPERVKFTLNMLVTMAPIVLILLGLLLFKMYPIDEERRRQ

--------------------------------------------------------------
>73503_73503_3_RERE-MFSD2A_RERE_chr1_8482786_ENST00000400907_MFSD2A_chr1_40422758_ENST00000372811_length(transcript)=3256nt_BP=1358nt
TGAAGCCCAGGCTTACTGTCTACCTTTCACGGAGGCCTAGCCGTGAGAGGACAGAAGAAGGCACGTGGCGAATCATGACAGCGGACAAAG
ACAAAGACAAAGACAAAGAGAAGGACCGGGACCGAGACCGGGACCGAGAGAGAGAGAAAAGAGACAAAGCAAGAGAGAGTGAGAATTCAA
GGCCACGCCGGAGCTGTACCTTGGAAGGAGGAGCCAAAAATTATGCTGAGAGTGATCACAGTGAAGACGAGGACAATGACAACAATAGTG
CCACCGCAGAGGAGTCCACGAAGAAGAATAAGAAGAAACCACCGAAAAAAAAGTCTCGTTATGAAAGGACAGATACCGGTGAGATAACAT
CCTACATCACTGAAGATGATGTGGTCTACAGACCAGGAGACTGTGTGTATATCGAGAGTCGGAGGCCAAACACACCGTATTTCATCTGTA
GCATTCAAGACTTCAAACTGGTCCACAACTCCCAGGCCTGTTGCAGATCTCCAACTCCTGCTTTGTGTGACCCCCCAGCATGCTCTCTGC
CGGTGGCATCACAGCCACCACAGCATCTTTCTGAAGCCGGGAGAGGGCCTGTAGGGAGTAAGAGGGACCATCTCCTCATGAACGTCAAAT
GGTACTACCGTCAATCTGAGGTTCCAGATTCTGTGTATCAGCATTTGGTTCAGGATCGACATAATGAAAATGACTCTGGAAGAGAACTTG
TCATTACAGACCCAGTTATCAAGAACCGAGAGCTCTTCATTTCTGATTACGTTGACACTTACCATGCTGCTGCCCTTAGAGGGAAGTGTA
ACATCTCCCATTTTTCTGACATATTTGCTGCTAGAGAGTTTAAAGCCCGAGTGGATTCATTTTTCTACATATTAGGATATAACCCTGAGA
CAAGGAGGCTGAACAGTACCCAGGGGGAGATTCGTGTCGGTCCTAGTCATCAGGCCAAACTTCCAGATCTGCAACCATTTCCTTCTCCAG
ATGGTGATACAGTGACCCAACATGAGGAACTGGTCTGGATGCCTGGAGTTAACGACTGTGACCTCCTTATGTACTTGAGGGCAGCAAGGA
GCATGGCGGCATTTGCAGGAATGTGTGATGGAGGCTCTACAGAGGACGGCTGTGTCGCAGCCTCTCGGGATGACACCACTCTGAATGCAC
TGAACACACTGCATGAAAGCGGTTACGATGCTGGCAAAGCCCTGCAGCGCCTGGTGAAGAAGCCTGTGCCCAAGCTCATCGAGAAGTGCT
GGACCGAGGACGAAGTGAAACGCTTCGTTAAGGGACTCAGGCAGTACGGGAAGAACTTCTTCAGAATTAGAAAGGAGCTGCTTCCCAATA
AGGAAACAAAAGAACCGAAAAAGAAGAAACAACAGTTGTCTGTTTGCAACAAGCTTTGCTATGCACTTGGGGGAGCCCCCTACCAGGTGA
CGGGCTGTGCCCTGGGTTTCTTCCTTCAGATCTACCTATTGGATGTGGCTCAGGTGGGCCCTTTCTCTGCCTCCATCATCCTGTTTGTGG
GCCGAGCCTGGGATGCCATCACAGACCCCCTGGTGGGCCTCTGCATCAGCAAATCCCCCTGGACCTGCCTGGGTCGCCTTATGCCCTGGA
TCATCTTCTCCACGCCCCTGGCCGTCATTGCCTACTTCCTCATCTGGTTCGTGCCCGACTTCCCACACGGCCAGACCTATTGGTACCTGC
TTTTCTATTGCCTCTTTGAAACAATGGTCACGTGTTTCCATGTTCCCTACTCGGCTCTCACCATGTTCATCAGCACCGAGCAGACTGAGC
GGGATTCTGCCACCGCCTATCGGATGACTGTGGAAGTGCTGGGCACAGTGCTGGGCACGGCGATCCAGGGACAAATCGTGGGCCAAGCAG
ACACGCCTTGTTTCCAGGACCTCAATAGCTCTACAGTAGCTTCACAAAGTGCCAACCATACACATGGCACCACCTCACACAGGGAAACGC
AAAAGGCATACCTGCTGGCAGCGGGGGTCATTGTCTGTATCTATATAATCTGTGCTGTCATCCTGATCCTGGGCGTGCGGGAGCAGAGAG
AACCCTATGAAGCCCAGCAGTCTGAGCCAATCGCCTACTTCCGGGGCCTACGGCTGGTCATGAGCCACGGCCCATACATCAAACTTATTA
CTGGCTTCCTCTTCACCTCCTTGGCTTTCATGCTGGTGGAGGGGAACTTTGTCTTGTTTTGCACCTACACCTTGGGCTTCCGCAATGAAT
TCCAGAATCTACTCCTGGCCATCATGCTCTCGGCCACTTTAACCATTCCCATCTGGCAGTGGTTCTTGACCCGGTTTGGCAAGAAGACAG
CTGTATATGTTGGGATCTCATCAGCAGTGCCATTTCTCATCTTGGTGGCCCTCATGGAGAGTAACCTCATCATTACATATGCGGTAGCTG
TGGCAGCTGGCATCAGTGTGGCAGCTGCCTTCTTACTACCCTGGTCCATGCTGCCTGATGTCATTGACGACTTCCATCTGAAGCAGCCCC
ACTTCCATGGAACCGAGCCCATCTTCTTCTCCTTCTATGTCTTCTTCACCAAGTTTGCCTCTGGAGTGTCACTGGGCATTTCTACCCTCA
GTCTGGACTTTGCAGGGTACCAGACCCGTGGCTGCTCGCAGCCGGAACGTGTCAAGTTTACACTGAACATGCTCGTGACCATGGCTCCCA
TAGTTCTCATCCTGCTGGGCCTGCTGCTCTTCAAAATGTACCCCATTGATGAGGAGAGGCGGCGGCAGAATAAGAAGGCCCTGCAGGCAC
TGAGGGACGAGGCCAGCAGCTCTGGCTGCTCAGAAACAGACTCCACAGAGCTGGCTAGCATCCTCTAGGGCCCGCCACGTTGCCCGAAGC
CACCATGCAGAAGGCCACAGAAGGGATCAGGACCTGTCTGCCGGCTTGCTGAGCAGCTGGACTGCAGGTGCTAGGAAGGGAACTGAAGAC
TCAAGGAGGTGGCCCAGGACACTTGCTGTGCTCACTGTGGGGCCGGCTGCTCTGTGGCCTCCTGCCTCCCCTCTGCCTGCCTGTGGGGCC
AAGCCCTGGGGCTGCCACTGTGAATATGCCAAGGACTGATCGGGCCTAGCCCGGAACACTAATGTAGAAACCTTTTTTTTTACAGAGCCT
AATTAATAACTTAATGACTGTGTACATAGCAATGTGTGTGTATGTATATGTCTGTGAGCTATTAATGTTATTAATTTTCATAAAAGCTGG

>73503_73503_3_RERE-MFSD2A_RERE_chr1_8482786_ENST00000400907_MFSD2A_chr1_40422758_ENST00000372811_length(amino acids)=927AA_BP=428
MTADKDKDKDKEKDRDRDRDREREKRDKARESENSRPRRSCTLEGGAKNYAESDHSEDEDNDNNSATAEESTKKNKKKPPKKKSRYERTD
TGEITSYITEDDVVYRPGDCVYIESRRPNTPYFICSIQDFKLVHNSQACCRSPTPALCDPPACSLPVASQPPQHLSEAGRGPVGSKRDHL
LMNVKWYYRQSEVPDSVYQHLVQDRHNENDSGRELVITDPVIKNRELFISDYVDTYHAAALRGKCNISHFSDIFAAREFKARVDSFFYIL
GYNPETRRLNSTQGEIRVGPSHQAKLPDLQPFPSPDGDTVTQHEELVWMPGVNDCDLLMYLRAARSMAAFAGMCDGGSTEDGCVAASRDD
TTLNALNTLHESGYDAGKALQRLVKKPVPKLIEKCWTEDEVKRFVKGLRQYGKNFFRIRKELLPNKETKEPKKKKQQLSVCNKLCYALGG
APYQVTGCALGFFLQIYLLDVAQVGPFSASIILFVGRAWDAITDPLVGLCISKSPWTCLGRLMPWIIFSTPLAVIAYFLIWFVPDFPHGQ
TYWYLLFYCLFETMVTCFHVPYSALTMFISTEQTERDSATAYRMTVEVLGTVLGTAIQGQIVGQADTPCFQDLNSSTVASQSANHTHGTT
SHRETQKAYLLAAGVIVCIYIICAVILILGVREQREPYEAQQSEPIAYFRGLRLVMSHGPYIKLITGFLFTSLAFMLVEGNFVLFCTYTL
GFRNEFQNLLLAIMLSATLTIPIWQWFLTRFGKKTAVYVGISSAVPFLILVALMESNLIITYAVAVAAGISVAAAFLLPWSMLPDVIDDF
HLKQPHFHGTEPIFFSFYVFFTKFASGVSLGISTLSLDFAGYQTRGCSQPERVKFTLNMLVTMAPIVLILLGLLLFKMYPIDEERRRQNK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RERE-MFSD2A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RERE-MFSD2A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RERE-MFSD2A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource