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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ATAD2-KHDRBS3 (FusionGDB2 ID:7352)

Fusion Gene Summary for ATAD2-KHDRBS3

Fusion gene summary

Fusion gene information	Fusion gene name: ATAD2-KHDRBS3
	Fusion gene ID: 7352
		Hgene	Tgene
	Gene symbol	ATAD2	KHDRBS3
	Gene ID	29028	10656
	Gene name	ATPase family AAA domain containing 2	KH RNA binding domain containing, signal transduction associated 3
	Synonyms	ANCCA\|CT137\|PRO2000	Etle\|SALP\|SLM-2\|SLM2\|T-STAR\|TSTAR\|etoile
	Cytomap	8q24.13	8q24.23
	Type of gene	protein-coding	protein-coding
	Description	ATPase family AAA domain-containing protein 2AAA nuclear coregulator cancer-associated protein	KH domain-containing, RNA-binding, signal transduction-associated protein 3KH domain containing, RNA binding, signal transduction associated 3RNA-binding protein T-StarSam68-like phosphotyrosine protein, T-STARsam68-like mammalian protein 2
	Modification date	20200322	20200313
	UniProtAcc	Q6PL18	O75525
	Ensembl transtripts involved in fusion gene	ENST00000287394, ENST00000521903, ENST00000534257,	ENST00000522578, ENST00000355849, ENST00000520981,
Fusion gene scores	* DoF score	18 X 16 X 9=2592	11 X 10 X 10=1100
	# samples	22	14
	** MAII score	log2(22/2592*10)=-3.55849028935997 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(14/1100*10)=-2.97400479146706 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ATAD2 [Title/Abstract] AND KHDRBS3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ATAD2(124346118)-KHDRBS3(136533480), # samples:3
Anticipated loss of major functional domain due to fusion event.	ATAD2-KHDRBS3 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. ATAD2-KHDRBS3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. ATAD2-KHDRBS3 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ATAD2	GO:0045893	positive regulation of transcription, DNA-templated	17998543

Fusion gene breakpoints across ATAD2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across KHDRBS3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	UCEC	TCGA-DF-A2KR-01A	ATAD2	chr8	124346118	-	KHDRBS3	chr8	136533480	+

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Fusion Gene ORF analysis for ATAD2-KHDRBS3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000287394	ENST00000522578	ATAD2	chr8	124346118	-	KHDRBS3	chr8	136533480	+
5CDS-intron	ENST00000521903	ENST00000522578	ATAD2	chr8	124346118	-	KHDRBS3	chr8	136533480	+
Frame-shift	ENST00000521903	ENST00000355849	ATAD2	chr8	124346118	-	KHDRBS3	chr8	136533480	+
Frame-shift	ENST00000521903	ENST00000520981	ATAD2	chr8	124346118	-	KHDRBS3	chr8	136533480	+
In-frame	ENST00000287394	ENST00000355849	ATAD2	chr8	124346118	-	KHDRBS3	chr8	136533480	+
In-frame	ENST00000287394	ENST00000520981	ATAD2	chr8	124346118	-	KHDRBS3	chr8	136533480	+
intron-3CDS	ENST00000534257	ENST00000355849	ATAD2	chr8	124346118	-	KHDRBS3	chr8	136533480	+
intron-3CDS	ENST00000534257	ENST00000520981	ATAD2	chr8	124346118	-	KHDRBS3	chr8	136533480	+
intron-intron	ENST00000534257	ENST00000522578	ATAD2	chr8	124346118	-	KHDRBS3	chr8	136533480	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000287394

ATAD2

chr8

124346118

ENST00000355849

KHDRBS3

chr8

136533480

5065

3586

108

4538

1476

ENST00000287394

ATAD2

chr8

124346118

ENST00000520981

KHDRBS3

chr8

136533480

4465

3586

108

3938

1276

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000287394	ENST00000355849	ATAD2	chr8	124346118	-	KHDRBS3	chr8	136533480	+	0.000451168	0.99954885
ENST00000287394	ENST00000520981	ATAD2	chr8	124346118	-	KHDRBS3	chr8	136533480	+	0.000462202	0.9995378

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Fusion Genomic Features for ATAD2-KHDRBS3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ATAD2	chr8	124346117	-	KHDRBS3	chr8	136533479	+	2.75E-05	0.99997246
ATAD2	chr8	124346117	-	KHDRBS3	chr8	136533479	+	2.75E-05	0.99997246

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ATAD2-KHDRBS3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:124346118/chr8:136533480)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ATAD2 Q6PL18	KHDRBS3 O75525
FUNCTION: May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. {ECO:0000269\|PubMed:17998543}.	FUNCTION: RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro. Binds optimally to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). RNA-binding abilities are down-regulated by tyrosine kinase PTK6 (PubMed:10564820, PubMed:19561594, PubMed:26758068). Involved in splice site selection of vascular endothelial growth factor (PubMed:15901763). In vitro regulates CD44 alternative splicing by direct binding to purine-rich exonic enhancer (By similarity). Can regulate alternative splicing of neurexins NRXN1-3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners such as neuroligins and LRRTM family members (PubMed:26758068). Targeted, cell-type specific splicing regulation of NRXN1 at AS4 is involved in neuronal glutamatergic synapse function and plasticity (By similarity). May regulate expression of KHDRBS2/SLIM-1 in defined brain neuron populations by modifying its alternative splicing (By similarity). Can bind FABP9 mRNA (By similarity). May play a role as a negative regulator of cell growth. Inhibits cell proliferation. {ECO:0000250\|UniProtKB:Q9JLP1, ECO:0000250\|UniProtKB:Q9R226, ECO:0000269\|PubMed:10564820, ECO:0000269\|PubMed:15901763, ECO:0000269\|PubMed:19561594, ECO:0000269\|PubMed:26758068}.; FUNCTION: (Microbial infection) Involved in post-transcriptional regulation of HIV-1 gene expression. {ECO:0000269\|PubMed:11741900}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ATAD2

chr8:124346118

chr8:136533480

ENST00000287394

1086_1112

1159

1391.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ATAD2

chr8:124346118

chr8:136533480

ENST00000287394

970_994

1159

1391.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ATAD2

chr8:124346118

chr8:136533480

ENST00000287394

250_285

1159

1391.0

Compositional bias

Note=Asp-rich

Hgene

ATAD2

chr8:124346118

chr8:136533480

ENST00000287394

357_366

1159

1391.0

Compositional bias

Note=Poly-Ser

Hgene

ATAD2

chr8:124346118

chr8:136533480

ENST00000287394

1001_1071

1159

1391.0

Domain

Bromo

Hgene

ATAD2

chr8:124346118

chr8:136533480

ENST00000287394

467_474

1159

1391.0

Nucleotide binding

ATP

Tgene

KHDRBS3

chr8:124346118

chr8:136533480

ENST00000355849

250_261

347.0

Compositional bias

Note=Pro-rich

Tgene

KHDRBS3

chr8:124346118

chr8:136533480

ENST00000355849

266_316

347.0

Compositional bias

Note=Tyr-rich

Tgene

KHDRBS3

chr8:124346118

chr8:136533480

ENST00000355849

61_127

347.0

Domain

Note=KH

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

KHDRBS3

chr8:124346118

chr8:136533480

ENST00000355849

1_160

347.0

Region

Involved in homodimerization

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Fusion Gene Sequence for ATAD2-KHDRBS3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>7352_7352_1_ATAD2-KHDRBS3_ATAD2_chr8_124346118_ENST00000287394_KHDRBS3_chr8_136533480_ENST00000355849_length(transcript)=5065nt_BP=3586nt
CGCGGAGCTTGTGGCGCCAGAATTCGGAGCGCGGAAGAGCCAGAGCTGCGAGCGCCTGGAGCTGGATCTCTCTCCGGTCGCGCACGCCGA
GGCCAGTAGGGAGAGAAGATGGTGGTTCTCCGCAGCAGCTTGGAGCTGCACAACCACTCCGCGGCCTCGGCCACGGGCTCCTTGGACCTG
TCCAGTGACTTCCTCAGTCTGGAGCACATCGGCCGGAGGCGGCTCCGCTCGGCCGGCGCGGCGCAGAAGAAACCCGCGGCGACCACAGCC
AAAGCGGGCGATGGGTCATCAGTTAAGGAAGTTGAAACCTACCACCGGACACGTGCTTTAAGATCTTTGAGAAAAGATGCACAGAATTCT
TCAGATTCTAGTTTTGAGAAGAATGTGGAAATAACGGAGCAACTTGCTAATGGCAGGCATTTTACAAGGCAGTTGGCCAGACAGCAGGCT
GATAAAAAAAAAGAAGAGCACAGAGAAGACAAAGTGATTCCAGTTACTCGGTCATTGAGGGCTAGAAACATCGTTCAAAGTACAGAACAC
TTACATGAAGATAATGGTGATGTTGAAGTGCGTCGAAGTTGTAGGATTAGAAGTCGTTATAGTGGTGTAAACCAGTCCATGCTGTTTGAC
AAACTTATAACTAACACTGCTGAAGCTGTACTTCAAAAAATGGATGACATGAAGAAGATGCGTAGACAGCGAATGAGAGAACTTGAAGAC
TTGGGAGTGTTTAATGAAACAGAAGAAAGCAATCTTAATATGTACACAAGAGGAAAACAGAAAGATATTCAAAGAACTGATGAAGAAACA
ACTGATAATCAAGAAGGCAGTGTGGAGTCATCTGAAGAGGGTGAAGACCAAGAACATGAAGATGATGGTGAAGATGAAGATGATGAAGAT
GATGATGATGATGACGATGATGATGATGATGATGATGATGAAGATGATGAAGATGAAGAAGATGGAGAAGAAGAGAATCAGAAGCGATAT
TATCTTAGACAGAGAAAAGCTACTGTTTACTATCAGGCTCCATTGGAAAAACCTCGTCACCAGAGAAAGCCCAACATATTTTATAGTGGC
CCAGCTTCTCCTGCAAGACCAAGATACCGATTATCTTCCGCAGGACCAAGAAGTCCTTACTGTAAACGAATGAACAGGCGAAGGCATGCA
ATCCACAGTAGTGACTCGACTTCATCTTCCTCCTCTGAAGATGAACAGCACTTTGAGAGGCGGAGGAAAAGGAGTCGTAATAGGGCTATC
AATAGGTGCCTCCCACTAAATTTTCGGAAAGATGAATTAAAAGGCATTTATAAAGATCGAATGAAAATTGGAGCAAGCCTTGCCGATGTT
GATCCAATGCAACTAGATTCTTCAGTACGATTTGATAGTGTTGGTGGCCTGTCTAATCATATAGCAGCTCTAAAAGAGATGGTGGTGTTT
CCATTACTTTATCCAGAAGTCTTTGAAAAATTTAAAATTCAACCCCCAAGAGGTTGTTTGTTTTATGGGCCACCTGGAACTGGAAAGACT
CTGGTTGCCAGAGCACTTGCCAATGAGTGCAGTCAAGGGGATAAAAGAGTAGCATTTTTCATGAGGAAAGGTGCTGATTGTCTAAGTAAA
TGGGTAGGAGAATCTGAAAGACAGCTACGATTGCTGTTTGATCAGGCCTATCAGATGCGCCCATCAATTATTTTTTTTGACGAAATTGAT
GGTCTGGCTCCAGTACGGTCAAGCAGGCAAGATCAGATTCACAGTTCTATTGTTTCCACCCTGCTAGCTCTTATGGATGGATTGGACAGC
AGAGGGGAAATTGTGGTCATTGGTGCTACGAACAGGCTAGATTCTATAGATCCTGCTTTACGAAGGCCTGGTCGCTTTGATAGAGAATTC
CTCTTTAGCCTGCCTGATAAAGAGGCTCGAAAAGAGATTCTAAAGATTCACACCAGGGATTGGAATCCCAAACCACTGGACACATTTTTA
GAAGAGCTAGCAGAAAACTGTGTTGGATACTGTGGAGCAGATATTAAATCAATATGTGCTGAAGCTGCTTTATGTGCTTTACGACGACGC
TACCCACAGATCTATACCACTAGTGAGAAACTGCAGTTGGATCTCTCTTCAATTAATATCTCAGCTAAGGATTTCGAGGTAGCTATGCAA
AAGATGATACCAGCCTCCCAAAGAGCTGTGACATCACCTGGGCAGGCACTGTCCACCGTTGTGAAACCACTCCTGCAAAACACTGTTGAC
AAGATTTTAGAAGCCCTGCAGAGAGTATTTCCACATGCAGAATTCAGAACAAATAAAACATTAGACTCAGATATTTCTTGTCCTCTGCTA
GAAAGTGACTTGGCTTACAGTGATGATGATGTTCCATCAGTTTATGAAAATGGACTTTCTCAGAAATCTTCTCATAAGGCAAAAGACAAT
TTTAATTTTCTTCATTTGAATAGAAATGCTTGTTACCAACCTATGTCTTTTCGACCAAGAATATTGATAGTAGGAGAACCAGGATTTGGG
CAAGGTTCTCACTTGGCACCAGCTGTCATTCATGCTTTGGAAAAGTTTACTGTATATACATTAGACATTCCTGTTCTTTTTGGAGTTAGT
ACTACATCCCCTGAAGAAACATGTGCCCAGGTGATTCGTGAAGCTAAGAGAACAGCACCAAGTATAGTGTATGTTCCTCATATCCACGTG
TGGTGGGAAATAGTTGGACCGACACTTAAAGCCACATTTACCACATTATTACAGAATATTCCTTCATTTGCTCCAGTTTTACTACTTGCA
ACTTCTGACAAACCCCATTCCGCTTTGCCAGAAGAGGTGCAAGAATTGTTTATCCGTGATTATGGAGAGATTTTTAATGTCCAGTTACCG
GATAAAGAAGAACGGACAAAATTTTTTGAAGATTTAATTCTAAAACAAGCTGCTAAGCCTCCTATATCAAAAAAGAAAGCAGTTTTGCAG
GCTTTGGAGGTACTCCCAGTAGCACCACCACCTGAGCCAAGATCACTGACAGCAGAAGAAGTGAAACGACTAGAAGAACAAGAAGAAGAT
ACATTTAGAGAACTGAGGATTTTCTTAAGAAATGTTACACATAGGCTTGCTATTGACAAGCGATTCCGAGTGTTTACTAAGCCTGTTGAC
CCTGATGAGGTTCCTGATTATGTCACTGTAATAAAGCAACCAATGGACCTTTCATCTGTAATCAGTAAAATTGATCTACACAAGTATCTG
ACTGTGAAAGACTATTTGAGAGATATTGATCTAATCTGTAGTAATGCCTTAGAATACAATCCAGATAGAGATCCTGGAGATCGTCTTATT
AGGCATAGAGCCTGTGCTTTAAGAGATACTGCCTATGCCATAATTAAAGAAGAACTTGATGAAGACTTTGAGCAGCTCTGTGAAGAAATT
CAGGAATCTAGAAAGAAAAGAGGTTGTAGCTCCTCCAAATATGCCCCGTCTTACTACCATGTGATGCCAAAGCAAAATTCCACTCTTGTT
GGTGATAAAAGATCAGACCCAGAGCAGAATGAAAAGCTAAAGACACCGAGTACTCCTGTGGCTTGCAGCACTCCTGAAATAGAAAAGTTT
CAAAAAGGAGAAGGCAAGGATGAAGAAAAGTACATCGATGTGGTGATTAATAAGAACATGAAGCTGGGACAGAAAGTGTTAATTCCCGTA
AAACAGTTCCCTAAGTTCAACTTTGTGGGGAAACTTTTGGGTCCACGTGGCAATTCTCTGAAGCGTTTACAAGAAGAAACCTTGACAAAA
ATGTCCATCCTTGGGAAAGGTTCCATGAGAGACAAGGCCAAGGAAGAAGAGTTGAGGAAAAGTGGAGAAGCGAAGTACTTCCATCTCAAT
GATGATCTCCATGTTCTCATTGAAGTGTTTGCCCCACCTGCAGAAGCTTATGCCAGGATGGGACATGCTTTGGAAGAAATCAAAAAGTTC
CTCATCCCTGATTATAATGATGAGATCAGGCAAGCACAGCTCCAGGAGTTAACATATTTGAATGGTGGTTCAGAAAATGCAGATGTTCCA
GTGGTTCGAGGGAAACCCACCTTGCGTACAAGAGGTGTACCAGCCCCAGCAATAACCAGGGGAAGGGGAGGAGTTACAGCCCGGCCAGTT
GGAGTTGTAGTACCACGAGGGACGCCAACTCCCAGAGGAGTCCTGTCCACCCGAGGGCCAGTGAGTCGGGGAAGAGGACTTCTCACTCCC
AGAGCAAGAGGAGTCCCCCCAACTGGGTACAGACCTCCACCGCCACCCCCGACACAAGAGACTTATGGAGAATATGACTATGATGATGGA
TATGGCACTGCTTATGATGAACAGAGTTATGATTCCTATGATAACAGCTATAGCACCCCAGCCCAAAGTGGTGCTGATTACTATGATTAC
GGACATGGACTCAGTGAGGAGACTTATGATTCCTACGGGCAAGAAGAGTGGACTAACTCAAGACACAAGGCACCTTCAGCGAGGACAGCA
AAGGGCGTCTACAGAGACCAGCCATATGGCAGATACTGATTGTACTGTCTGATGTTGTGAAATAGCCAATCTCCACCAGTCCTGTATACT
GTTCAAAGTAATTTTTTTCTATGAACAATCCCTTTTTAAATAAATCAGAATGCTTAAAATCTGAATGGATGGAACTTAAAACTACTTTGT
TGAAACATCAACCTGGGCAGAAAAAAAAAAAAAAAGACATGTAAAATTTTGTTATTTCCAGTCTGTATATGAAAAAATAGGTCATCAAAA
GGAAAAAAAATAACTTTGATTAACTAGTGTTAAACAAAAAATAGGTTTACTAAATATGTTAATCTATTCTTTTAACATAAGCCTCACCTT
TCATTTTAAAGGTTTCCATAGAATTTAGTTATTTTATCTTTCAGCCATATGCTAGTTTTTTTTTCTCTTGCCAACATGCGTAAAAAGGGA
AGCCAATTACAAGTGCAAATAATGTGGTATTCTTTTGTAACTCAAGTCTTGAAATGTTCTGTAGTGTTAAGCAAAGTCTCCTCTTGCTTG

>7352_7352_1_ATAD2-KHDRBS3_ATAD2_chr8_124346118_ENST00000287394_KHDRBS3_chr8_136533480_ENST00000355849_length(amino acids)=1476AA_BP=1159
MVVLRSSLELHNHSAASATGSLDLSSDFLSLEHIGRRRLRSAGAAQKKPAATTAKAGDGSSVKEVETYHRTRALRSLRKDAQNSSDSSFE
KNVEITEQLANGRHFTRQLARQQADKKKEEHREDKVIPVTRSLRARNIVQSTEHLHEDNGDVEVRRSCRIRSRYSGVNQSMLFDKLITNT
AEAVLQKMDDMKKMRRQRMRELEDLGVFNETEESNLNMYTRGKQKDIQRTDEETTDNQEGSVESSEEGEDQEHEDDGEDEDDEDDDDDDD
DDDDDDDEDDEDEEDGEEENQKRYYLRQRKATVYYQAPLEKPRHQRKPNIFYSGPASPARPRYRLSSAGPRSPYCKRMNRRRHAIHSSDS
TSSSSSEDEQHFERRRKRSRNRAINRCLPLNFRKDELKGIYKDRMKIGASLADVDPMQLDSSVRFDSVGGLSNHIAALKEMVVFPLLYPE
VFEKFKIQPPRGCLFYGPPGTGKTLVARALANECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMRPSIIFFDEIDGLAPVR
SSRQDQIHSSIVSTLLALMDGLDSRGEIVVIGATNRLDSIDPALRRPGRFDREFLFSLPDKEARKEILKIHTRDWNPKPLDTFLEELAEN
CVGYCGADIKSICAEAALCALRRRYPQIYTTSEKLQLDLSSINISAKDFEVAMQKMIPASQRAVTSPGQALSTVVKPLLQNTVDKILEAL
QRVFPHAEFRTNKTLDSDISCPLLESDLAYSDDDVPSVYENGLSQKSSHKAKDNFNFLHLNRNACYQPMSFRPRILIVGEPGFGQGSHLA
PAVIHALEKFTVYTLDIPVLFGVSTTSPEETCAQVIREAKRTAPSIVYVPHIHVWWEIVGPTLKATFTTLLQNIPSFAPVLLLATSDKPH
SALPEEVQELFIRDYGEIFNVQLPDKEERTKFFEDLILKQAAKPPISKKKAVLQALEVLPVAPPPEPRSLTAEEVKRLEEQEEDTFRELR
IFLRNVTHRLAIDKRFRVFTKPVDPDEVPDYVTVIKQPMDLSSVISKIDLHKYLTVKDYLRDIDLICSNALEYNPDRDPGDRLIRHRACA
LRDTAYAIIKEELDEDFEQLCEEIQESRKKRGCSSSKYAPSYYHVMPKQNSTLVGDKRSDPEQNEKLKTPSTPVACSTPEIEKFQKGEGK
DEEKYIDVVINKNMKLGQKVLIPVKQFPKFNFVGKLLGPRGNSLKRLQEETLTKMSILGKGSMRDKAKEEELRKSGEAKYFHLNDDLHVL
IEVFAPPAEAYARMGHALEEIKKFLIPDYNDEIRQAQLQELTYLNGGSENADVPVVRGKPTLRTRGVPAPAITRGRGGVTARPVGVVVPR
GTPTPRGVLSTRGPVSRGRGLLTPRARGVPPTGYRPPPPPPTQETYGEYDYDDGYGTAYDEQSYDSYDNSYSTPAQSGADYYDYGHGLSE

--------------------------------------------------------------
>7352_7352_2_ATAD2-KHDRBS3_ATAD2_chr8_124346118_ENST00000287394_KHDRBS3_chr8_136533480_ENST00000520981_length(transcript)=4465nt_BP=3586nt
CGCGGAGCTTGTGGCGCCAGAATTCGGAGCGCGGAAGAGCCAGAGCTGCGAGCGCCTGGAGCTGGATCTCTCTCCGGTCGCGCACGCCGA
GGCCAGTAGGGAGAGAAGATGGTGGTTCTCCGCAGCAGCTTGGAGCTGCACAACCACTCCGCGGCCTCGGCCACGGGCTCCTTGGACCTG
TCCAGTGACTTCCTCAGTCTGGAGCACATCGGCCGGAGGCGGCTCCGCTCGGCCGGCGCGGCGCAGAAGAAACCCGCGGCGACCACAGCC
AAAGCGGGCGATGGGTCATCAGTTAAGGAAGTTGAAACCTACCACCGGACACGTGCTTTAAGATCTTTGAGAAAAGATGCACAGAATTCT
TCAGATTCTAGTTTTGAGAAGAATGTGGAAATAACGGAGCAACTTGCTAATGGCAGGCATTTTACAAGGCAGTTGGCCAGACAGCAGGCT
GATAAAAAAAAAGAAGAGCACAGAGAAGACAAAGTGATTCCAGTTACTCGGTCATTGAGGGCTAGAAACATCGTTCAAAGTACAGAACAC
TTACATGAAGATAATGGTGATGTTGAAGTGCGTCGAAGTTGTAGGATTAGAAGTCGTTATAGTGGTGTAAACCAGTCCATGCTGTTTGAC
AAACTTATAACTAACACTGCTGAAGCTGTACTTCAAAAAATGGATGACATGAAGAAGATGCGTAGACAGCGAATGAGAGAACTTGAAGAC
TTGGGAGTGTTTAATGAAACAGAAGAAAGCAATCTTAATATGTACACAAGAGGAAAACAGAAAGATATTCAAAGAACTGATGAAGAAACA
ACTGATAATCAAGAAGGCAGTGTGGAGTCATCTGAAGAGGGTGAAGACCAAGAACATGAAGATGATGGTGAAGATGAAGATGATGAAGAT
GATGATGATGATGACGATGATGATGATGATGATGATGATGAAGATGATGAAGATGAAGAAGATGGAGAAGAAGAGAATCAGAAGCGATAT
TATCTTAGACAGAGAAAAGCTACTGTTTACTATCAGGCTCCATTGGAAAAACCTCGTCACCAGAGAAAGCCCAACATATTTTATAGTGGC
CCAGCTTCTCCTGCAAGACCAAGATACCGATTATCTTCCGCAGGACCAAGAAGTCCTTACTGTAAACGAATGAACAGGCGAAGGCATGCA
ATCCACAGTAGTGACTCGACTTCATCTTCCTCCTCTGAAGATGAACAGCACTTTGAGAGGCGGAGGAAAAGGAGTCGTAATAGGGCTATC
AATAGGTGCCTCCCACTAAATTTTCGGAAAGATGAATTAAAAGGCATTTATAAAGATCGAATGAAAATTGGAGCAAGCCTTGCCGATGTT
GATCCAATGCAACTAGATTCTTCAGTACGATTTGATAGTGTTGGTGGCCTGTCTAATCATATAGCAGCTCTAAAAGAGATGGTGGTGTTT
CCATTACTTTATCCAGAAGTCTTTGAAAAATTTAAAATTCAACCCCCAAGAGGTTGTTTGTTTTATGGGCCACCTGGAACTGGAAAGACT
CTGGTTGCCAGAGCACTTGCCAATGAGTGCAGTCAAGGGGATAAAAGAGTAGCATTTTTCATGAGGAAAGGTGCTGATTGTCTAAGTAAA
TGGGTAGGAGAATCTGAAAGACAGCTACGATTGCTGTTTGATCAGGCCTATCAGATGCGCCCATCAATTATTTTTTTTGACGAAATTGAT
GGTCTGGCTCCAGTACGGTCAAGCAGGCAAGATCAGATTCACAGTTCTATTGTTTCCACCCTGCTAGCTCTTATGGATGGATTGGACAGC
AGAGGGGAAATTGTGGTCATTGGTGCTACGAACAGGCTAGATTCTATAGATCCTGCTTTACGAAGGCCTGGTCGCTTTGATAGAGAATTC
CTCTTTAGCCTGCCTGATAAAGAGGCTCGAAAAGAGATTCTAAAGATTCACACCAGGGATTGGAATCCCAAACCACTGGACACATTTTTA
GAAGAGCTAGCAGAAAACTGTGTTGGATACTGTGGAGCAGATATTAAATCAATATGTGCTGAAGCTGCTTTATGTGCTTTACGACGACGC
TACCCACAGATCTATACCACTAGTGAGAAACTGCAGTTGGATCTCTCTTCAATTAATATCTCAGCTAAGGATTTCGAGGTAGCTATGCAA
AAGATGATACCAGCCTCCCAAAGAGCTGTGACATCACCTGGGCAGGCACTGTCCACCGTTGTGAAACCACTCCTGCAAAACACTGTTGAC
AAGATTTTAGAAGCCCTGCAGAGAGTATTTCCACATGCAGAATTCAGAACAAATAAAACATTAGACTCAGATATTTCTTGTCCTCTGCTA
GAAAGTGACTTGGCTTACAGTGATGATGATGTTCCATCAGTTTATGAAAATGGACTTTCTCAGAAATCTTCTCATAAGGCAAAAGACAAT
TTTAATTTTCTTCATTTGAATAGAAATGCTTGTTACCAACCTATGTCTTTTCGACCAAGAATATTGATAGTAGGAGAACCAGGATTTGGG
CAAGGTTCTCACTTGGCACCAGCTGTCATTCATGCTTTGGAAAAGTTTACTGTATATACATTAGACATTCCTGTTCTTTTTGGAGTTAGT
ACTACATCCCCTGAAGAAACATGTGCCCAGGTGATTCGTGAAGCTAAGAGAACAGCACCAAGTATAGTGTATGTTCCTCATATCCACGTG
TGGTGGGAAATAGTTGGACCGACACTTAAAGCCACATTTACCACATTATTACAGAATATTCCTTCATTTGCTCCAGTTTTACTACTTGCA
ACTTCTGACAAACCCCATTCCGCTTTGCCAGAAGAGGTGCAAGAATTGTTTATCCGTGATTATGGAGAGATTTTTAATGTCCAGTTACCG
GATAAAGAAGAACGGACAAAATTTTTTGAAGATTTAATTCTAAAACAAGCTGCTAAGCCTCCTATATCAAAAAAGAAAGCAGTTTTGCAG
GCTTTGGAGGTACTCCCAGTAGCACCACCACCTGAGCCAAGATCACTGACAGCAGAAGAAGTGAAACGACTAGAAGAACAAGAAGAAGAT
ACATTTAGAGAACTGAGGATTTTCTTAAGAAATGTTACACATAGGCTTGCTATTGACAAGCGATTCCGAGTGTTTACTAAGCCTGTTGAC
CCTGATGAGGTTCCTGATTATGTCACTGTAATAAAGCAACCAATGGACCTTTCATCTGTAATCAGTAAAATTGATCTACACAAGTATCTG
ACTGTGAAAGACTATTTGAGAGATATTGATCTAATCTGTAGTAATGCCTTAGAATACAATCCAGATAGAGATCCTGGAGATCGTCTTATT
AGGCATAGAGCCTGTGCTTTAAGAGATACTGCCTATGCCATAATTAAAGAAGAACTTGATGAAGACTTTGAGCAGCTCTGTGAAGAAATT
CAGGAATCTAGAAAGAAAAGAGGTTGTAGCTCCTCCAAATATGCCCCGTCTTACTACCATGTGATGCCAAAGCAAAATTCCACTCTTGTT
GGTGATAAAAGATCAGACCCAGAGCAGAATGAAAAGCTAAAGACACCGAGTACTCCTGTGGCTTGCAGCACTCCTGAAATAGAAAAGTTT
CAAAAAGGAGAAGGCAAGGATGAAGAAAAGTACATCGATGTGGTGATTAATAAGAACATGAAGCTGGGACAGAAAGTGTTAATTCCCGTA
AAACAGTTCCCTAAGGACTATGATGATGGATATGGCACTGCTTATGATGAACAGAGTTATGATTCCTATGATAACAGCTATAGCACCCCA
GCCCAAAGTGGTGCTGATTACTATGATTACGGACATGGACTCAGTGAGGAGACTTATGATTCCTACGGGCAAGAAGAGTGGACTAACTCA
AGACACAAGGCACCTTCAGCGAGGACAGCAAAGGGCGTCTACAGAGACCAGCCATATGGCAGATACTGATTGTACTGTCTGATGTTGTGA
AATAGCCAATCTCCACCAGTCCTGTATACTGTTCAAAGTAATTTTTTTCTATGAACAATCCCTTTTTAAATAAATCAGAATGCTTAAAAT
CTGAATGGATGGAACTTAAAACTACTTTGTTGAAACATCAACCTGGGCAGAAAAAAAAAAAAAAAGACATGTAAAATTTTGTTATTTCCA
GTCTGTATATGAAAAAATAGGTCATCAAAAGGAAAAAAAATAACTTTGATTAACTAGTGTTAAACAAAAAATAGGTTTACTAAATATGTT
AATCTATTCTTTTAACATAAGCCTCACCTTTCATTTTAAAGGTTTCCATAGAATTTAGTTATTTTATCTTTCAGCCATATGCTAGTTTTT
TTTTCTCTTGCCAACATGCGTAAAAAGGGAAGCCAATTACAAGTGCAAATAATGTGGTATTCTTTTGTAACTCAAGTCTTGAAATGTTCT

>7352_7352_2_ATAD2-KHDRBS3_ATAD2_chr8_124346118_ENST00000287394_KHDRBS3_chr8_136533480_ENST00000520981_length(amino acids)=1276AA_BP=1159
MVVLRSSLELHNHSAASATGSLDLSSDFLSLEHIGRRRLRSAGAAQKKPAATTAKAGDGSSVKEVETYHRTRALRSLRKDAQNSSDSSFE
KNVEITEQLANGRHFTRQLARQQADKKKEEHREDKVIPVTRSLRARNIVQSTEHLHEDNGDVEVRRSCRIRSRYSGVNQSMLFDKLITNT
AEAVLQKMDDMKKMRRQRMRELEDLGVFNETEESNLNMYTRGKQKDIQRTDEETTDNQEGSVESSEEGEDQEHEDDGEDEDDEDDDDDDD
DDDDDDDEDDEDEEDGEEENQKRYYLRQRKATVYYQAPLEKPRHQRKPNIFYSGPASPARPRYRLSSAGPRSPYCKRMNRRRHAIHSSDS
TSSSSSEDEQHFERRRKRSRNRAINRCLPLNFRKDELKGIYKDRMKIGASLADVDPMQLDSSVRFDSVGGLSNHIAALKEMVVFPLLYPE
VFEKFKIQPPRGCLFYGPPGTGKTLVARALANECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMRPSIIFFDEIDGLAPVR
SSRQDQIHSSIVSTLLALMDGLDSRGEIVVIGATNRLDSIDPALRRPGRFDREFLFSLPDKEARKEILKIHTRDWNPKPLDTFLEELAEN
CVGYCGADIKSICAEAALCALRRRYPQIYTTSEKLQLDLSSINISAKDFEVAMQKMIPASQRAVTSPGQALSTVVKPLLQNTVDKILEAL
QRVFPHAEFRTNKTLDSDISCPLLESDLAYSDDDVPSVYENGLSQKSSHKAKDNFNFLHLNRNACYQPMSFRPRILIVGEPGFGQGSHLA
PAVIHALEKFTVYTLDIPVLFGVSTTSPEETCAQVIREAKRTAPSIVYVPHIHVWWEIVGPTLKATFTTLLQNIPSFAPVLLLATSDKPH
SALPEEVQELFIRDYGEIFNVQLPDKEERTKFFEDLILKQAAKPPISKKKAVLQALEVLPVAPPPEPRSLTAEEVKRLEEQEEDTFRELR
IFLRNVTHRLAIDKRFRVFTKPVDPDEVPDYVTVIKQPMDLSSVISKIDLHKYLTVKDYLRDIDLICSNALEYNPDRDPGDRLIRHRACA
LRDTAYAIIKEELDEDFEQLCEEIQESRKKRGCSSSKYAPSYYHVMPKQNSTLVGDKRSDPEQNEKLKTPSTPVACSTPEIEKFQKGEGK
DEEKYIDVVINKNMKLGQKVLIPVKQFPKDYDDGYGTAYDEQSYDSYDNSYSTPAQSGADYYDYGHGLSEETYDSYGQEEWTNSRHKAPS

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Fusion Gene PPI Analysis for ATAD2-KHDRBS3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ATAD2-KHDRBS3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for ATAD2-KHDRBS3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source