|
||||||
|
 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:RET-GOLGA5 (FusionGDB2 ID:73558) |
Fusion Gene Summary for RET-GOLGA5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RET-GOLGA5 | Fusion gene ID: 73558 | Hgene | Tgene | Gene symbol | RET | GOLGA5 | Gene ID | 5979 | 440270 |
| Gene name | ret proto-oncogene | golgin A8 family member B | |
| Synonyms | CDHF12|CDHR16|HSCR1|MEN2A|MEN2B|MTC1|PTC|RET-ELE1 | GOLGA5 | |
| Cytomap | 10q11.21 | 15q14 | |
| Type of gene | protein-coding | protein-coding | |
| Description | proto-oncogene tyrosine-protein kinase receptor RetRET receptor tyrosine kinasecadherin family member 12cadherin-related family member 16proto-oncogene c-Retrearranged during transfectionret proto-oncogene (multiple endocrine neoplasia and medullary | golgin subfamily A member 8Bgolgi autoantigen, golgin subfamily a, 8Bgolgin-67 | |
| Modification date | 20200322 | 20200313 | |
| UniProtAcc | RFPL2 | Q8TBA6 | |
| Ensembl transtripts involved in fusion gene | ENST00000340058, ENST00000355710, | ENST00000163416, ENST00000355976, | |
| Fusion gene scores | * DoF score | 9 X 6 X 4=216 | 10 X 9 X 5=450 |
| # samples | 9 | 10 | |
| ** MAII score | log2(9/216*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/450*10)=-2.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RET [Title/Abstract] AND GOLGA5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | GOLGA5(93282767)-RET(43612030), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RET | GO:0030155 | regulation of cell adhesion | 21357690 |
| Hgene | RET | GO:0030335 | positive regulation of cell migration | 20702524 |
| Hgene | RET | GO:0033619 | membrane protein proteolysis | 21357690 |
| Hgene | RET | GO:0033630 | positive regulation of cell adhesion mediated by integrin | 20702524 |
| Hgene | RET | GO:0035860 | glial cell-derived neurotrophic factor receptor signaling pathway | 28953886 |
| Hgene | RET | GO:0043410 | positive regulation of MAPK cascade | 28846099 |
| Fusion gene breakpoints across RET (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across GOLGA5 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerKB3 | . | . | RET | chr10 | 43610184 | + | GOLGA5 | chr14 | 93286052 | + |
Top |
Fusion Gene ORF analysis for RET-GOLGA5 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000340058 | ENST00000163416 | RET | chr10 | 43610184 | + | GOLGA5 | chr14 | 93286052 | + |
| In-frame | ENST00000340058 | ENST00000355976 | RET | chr10 | 43610184 | + | GOLGA5 | chr14 | 93286052 | + |
| In-frame | ENST00000355710 | ENST00000163416 | RET | chr10 | 43610184 | + | GOLGA5 | chr14 | 93286052 | + |
| In-frame | ENST00000355710 | ENST00000355976 | RET | chr10 | 43610184 | + | GOLGA5 | chr14 | 93286052 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000355710 | RET | chr10 | 43610184 | + | ENST00000163416 | GOLGA5 | chr14 | 93286052 | + | 3590 | 2368 | 232 | 3072 | 946 |
| ENST00000355710 | RET | chr10 | 43610184 | + | ENST00000355976 | GOLGA5 | chr14 | 93286052 | + | 3522 | 2368 | 232 | 2952 | 906 |
| ENST00000340058 | RET | chr10 | 43610184 | + | ENST00000163416 | GOLGA5 | chr14 | 93286052 | + | 3538 | 2316 | 180 | 3020 | 946 |
| ENST00000340058 | RET | chr10 | 43610184 | + | ENST00000355976 | GOLGA5 | chr14 | 93286052 | + | 3470 | 2316 | 180 | 2900 | 906 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
Top |
Fusion Genomic Features for RET-GOLGA5 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
Top |
Fusion Protein Features for RET-GOLGA5 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:93282767/chr14:43612030) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RET | GOLGA5 |
| 378 | FUNCTION: Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport. {ECO:0000269|PubMed:12538640, ECO:0000269|PubMed:15718469}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
Fusion Gene Sequence for RET-GOLGA5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >73558_73558_1_RET-GOLGA5_RET_chr10_43610184_ENST00000340058_GOLGA5_chr14_93286052_ENST00000163416_length(transcript)=3538nt_BP=2316nt CCGAAGCAGGGCGCGCAGCAGCGCTGAGTGCCCCGGAACGTGCGTCGCGCCCCCAGTGTCCGTCGCGTCCGCCGCGCCCCGGGCGGGGAT GGGGCGGCCAGACTGAGCGCCGCACCCGCCATCCAGACCCGCCGGCCCTAGCCGCAGTCCCTCCAGCCGTGGCCCCAGCGCGCACGGGCG ATGGCGAAGGCGACGTCCGGTGCCGCGGGGCTGCGTCTGCTGTTGCTGCTGCTGCTGCCGCTGCTAGGCAAAGTGGCATTGGGCCTCTAC TTCTCGAGGGATGCTTACTGGGAGAAGCTGTATGTGGACCAGGCAGCCGGCACGCCCTTGCTGTACGTCCATGCCCTGCGGGACGCCCCT GAGGAGGTGCCCAGCTTCCGCCTGGGCCAGCATCTCTACGGCACGTACCGCACACGGCTGCATGAGAACAACTGGATCTGCATCCAGGAG GACACCGGCCTCCTCTACCTTAACCGGAGCCTGGACCATAGCTCCTGGGAGAAGCTCAGTGTCCGCAACCGCGGCTTTCCCCTGCTCACC GTCTACCTCAAGGTCTTCCTGTCACCCACATCCCTTCGTGAGGGCGAGTGCCAGTGGCCAGGCTGTGCCCGCGTATACTTCTCCTTCTTC AACACCTCCTTTCCAGCCTGCAGCTCCCTCAAGCCCCGGGAGCTCTGCTTCCCAGAGACAAGGCCCTCCTTCCGCATTCGGGAGAACCGA CCCCCAGGCACCTTCCACCAGTTCCGCCTGCTGCCTGTGCAGTTCTTGTGCCCCAACATCAGCGTGGCCTACAGGCTCCTGGAGGGTGAG GGTCTGCCCTTCCGCTGCGCCCCGGACAGCCTGGAGGTGAGCACGCGCTGGGCCCTGGACCGCGAGCAGCGGGAGAAGTACGAGCTGGTG GCCGTGTGCACCGTGCACGCCGGCGCGCGCGAGGAGGTGGTGATGGTGCCCTTCCCGGTGACCGTGTACGACGAGGACGACTCGGCGCCC ACCTTCCCCGCGGGCGTCGACACCGCCAGCGCCGTGGTGGAGTTCAAGCGGAAGGAGGACACCGTGGTGGCCACGCTGCGTGTCTTCGAT GCAGACGTGGTACCTGCATCAGGGGAGCTGGTGAGGCGGTACACAAGCACGCTGCTCCCCGGGGACACCTGGGCCCAGCAGACCTTCCGG GTGGAACACTGGCCCAACGAGACCTCGGTCCAGGCCAACGGCAGCTTCGTGCGGGCGACCGTACATGACTATAGGCTGGTTCTCAACCGG AACCTCTCCATCTCGGAGAACCGCACCATGCAGCTGGCGGTGCTGGTCAATGACTCAGACTTCCAGGGCCCAGGAGCGGGCGTCCTCTTG CTCCACTTCAACGTGTCGGTGCTGCCGGTCAGCCTGCACCTGCCCAGTACCTACTCCCTCTCCGTGAGCAGGAGGGCTCGCCGATTTGCC CAGATCGGGAAAGTCTGTGTGGAAAACTGCCAGGCATTCAGTGGCATCAACGTCCAGTACAAGCTGCATTCCTCTGGTGCCAACTGCAGC ACGCTAGGGGTGGTCACCTCAGCCGAGGACACCTCGGGGATCCTGTTTGTGAATGACACCAAGGCCCTGCGGCGGCCCAAGTGTGCCGAA CTTCACTACATGGTGGTGGCCACCGACCAGCAGACCTCTAGGCAGGCCCAGGCCCAGCTGCTTGTAACAGTGGAGGGGTCATATGTGGCC GAGGAGGCGGGCTGCCCCCTGTCCTGTGCAGTCAGCAAGAGACGGCTGGAGTGTGAGGAGTGTGGCGGCCTGGGCTCCCCAACAGGCAGG TGTGAGTGGAGGCAAGGAGATGGCAAAGGGATCACCAGGAACTTCTCCACCTGCTCTCCCAGCACCAAGACCTGCCCCGACGGCCACTGC GATGTTGTGGAGACCCAAGACATCAACATTTGCCCTCAGGACTGCCTCCGGGGCAGCATTGTTGGGGGACACGAGCCTGGGGAGCCCCGG GGGATTAAAGCTGGCTATGGCACCTGCAACTGCTTCCCTGAGGAGGAGAAGTGCTTCTGCGAGCCCGAAGACATCCAGGATCCACTGTGC GACGAGCTGTGCCGCACGGTGATCGCAGCCGCTGTCCTCTTCTCCTTCATCGTCTCGGTGCTGCTGTCTGCCTTCTGCATCCACTGCTAC CACAAGTTTGCCCACAAGCCACCCATCTCCTCAGCTGAGATGACCTTCCGGAGGCCCGCCCAGGCCTTCCCGGTCAGCTACTCCTCTTCC GGTGCCCGCCGGCCCTCGCTGGACTCCATGGAGAACCAGGTCTCCGTGGATGCCTTCAAGATCCTGGATATGGAGGCACAGCAAGTTAAT GAAGCAGAATCAGCAAGAGAACAGTTACAGGATCTGCATGACCAAATAGCTGGGCAGAAAGCATCCAAACAAGAACTAGAGACAGAACTG GAGCGACTGAAGCAGGAGTTCCACTATATAGAAGAAGATCTTTATCGAACAAAGAACACATTGCAAAGCAGAATTAAAGATCGAGACGAA GAAATTCAAAAACTCAGGAATCAGCTTACCAATAAAACTTTAAGCAATAGCAGTCAGTCTGAGTTAGAAAATCGACTCCATCAGCTAACA GAGACTCTCATCCAGAAACAGACCATGCTGGAGAGTCTCAGCACAGAAAAGAACTCCCTGGTCTTTCAACTGGAGCGCCTCGAACAGCAG ATGAACTCCGCCTCTGGAAGTAGTAGTAATGGGTCTTCGATTAATATGTCTGGAATTGACAATGGTGAAGGCACTCGTCTGCGAAATGTT CCTGTTCTTTTTAATGACACAGAAACTAATCTGGCAGGAATGTACGGAAAAGTTCGCAAAGCTGCTAGTTCAATTGATCAGTTTAGTATT CGCCTGGGAATTTTTCTCCGAAGATACCCCATAGCGCGAGTTTTTGTAATTATATATATGGCTTTGCTTCACCTCTGGGTCATGATTGTT CTGTTGACTTACACACCAGAAATGCACCACGACCAACCATATGGCAAATGAACCAAGCCCAGTTGTTGCAGTGATTGGTTGTCTTTTTCT AGACTTGGGATCTGCAAGAAGGCCAATTGCCTAAAATTTCTGAGAACAGTGCACAAGATTATTTTATCACTACAAGCTTTTAACTTTTTA AGTTATTGTACAAGTATTCTACCTAAATCTTCCAATTTCCTTTAAATGGTAAGAGTTTCTAAAACAGACAATAATTTAACAAGCTCAGCT CTGCTTTATCTGAGTTTAGTGGTCCTAATATATATGTAGAGAAAGATGGTGGGGTTGTTCACCTCTGTACAGACCATCTGTATGTTAGGT GACATTGATTATGGGTTATAATCAGGGAAACTAATTGTATTTAGTGACAAAAATAAAAAGTTTTTTTTTATAATTCAGTCTGCTTTTGGA TTTTCATATATTTAACTTTGCAAAAAGATTTACTTTGTACATGTTACAGGCTTGATTGGTGTAAATCTTTTTATAAATACATAAATAAAA >73558_73558_1_RET-GOLGA5_RET_chr10_43610184_ENST00000340058_GOLGA5_chr14_93286052_ENST00000163416_length(amino acids)=946AA_BP=707 MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQE DTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENR PPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAP TFPAGVDTASAVVEFKRKEDTVVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNR NLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCS TLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGR CEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLC DELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILDMEAQQVN EAESAREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLT ETLIQKQTMLESLSTEKNSLVFQLERLEQQMNSASGSSSNGSSINMSGIDNGEGTRLRNVPVLFNDTETNLAGMYGKVRKAASSIDQFSI -------------------------------------------------------------- >73558_73558_2_RET-GOLGA5_RET_chr10_43610184_ENST00000340058_GOLGA5_chr14_93286052_ENST00000355976_length(transcript)=3470nt_BP=2316nt CCGAAGCAGGGCGCGCAGCAGCGCTGAGTGCCCCGGAACGTGCGTCGCGCCCCCAGTGTCCGTCGCGTCCGCCGCGCCCCGGGCGGGGAT GGGGCGGCCAGACTGAGCGCCGCACCCGCCATCCAGACCCGCCGGCCCTAGCCGCAGTCCCTCCAGCCGTGGCCCCAGCGCGCACGGGCG ATGGCGAAGGCGACGTCCGGTGCCGCGGGGCTGCGTCTGCTGTTGCTGCTGCTGCTGCCGCTGCTAGGCAAAGTGGCATTGGGCCTCTAC TTCTCGAGGGATGCTTACTGGGAGAAGCTGTATGTGGACCAGGCAGCCGGCACGCCCTTGCTGTACGTCCATGCCCTGCGGGACGCCCCT GAGGAGGTGCCCAGCTTCCGCCTGGGCCAGCATCTCTACGGCACGTACCGCACACGGCTGCATGAGAACAACTGGATCTGCATCCAGGAG GACACCGGCCTCCTCTACCTTAACCGGAGCCTGGACCATAGCTCCTGGGAGAAGCTCAGTGTCCGCAACCGCGGCTTTCCCCTGCTCACC GTCTACCTCAAGGTCTTCCTGTCACCCACATCCCTTCGTGAGGGCGAGTGCCAGTGGCCAGGCTGTGCCCGCGTATACTTCTCCTTCTTC AACACCTCCTTTCCAGCCTGCAGCTCCCTCAAGCCCCGGGAGCTCTGCTTCCCAGAGACAAGGCCCTCCTTCCGCATTCGGGAGAACCGA CCCCCAGGCACCTTCCACCAGTTCCGCCTGCTGCCTGTGCAGTTCTTGTGCCCCAACATCAGCGTGGCCTACAGGCTCCTGGAGGGTGAG GGTCTGCCCTTCCGCTGCGCCCCGGACAGCCTGGAGGTGAGCACGCGCTGGGCCCTGGACCGCGAGCAGCGGGAGAAGTACGAGCTGGTG GCCGTGTGCACCGTGCACGCCGGCGCGCGCGAGGAGGTGGTGATGGTGCCCTTCCCGGTGACCGTGTACGACGAGGACGACTCGGCGCCC ACCTTCCCCGCGGGCGTCGACACCGCCAGCGCCGTGGTGGAGTTCAAGCGGAAGGAGGACACCGTGGTGGCCACGCTGCGTGTCTTCGAT GCAGACGTGGTACCTGCATCAGGGGAGCTGGTGAGGCGGTACACAAGCACGCTGCTCCCCGGGGACACCTGGGCCCAGCAGACCTTCCGG GTGGAACACTGGCCCAACGAGACCTCGGTCCAGGCCAACGGCAGCTTCGTGCGGGCGACCGTACATGACTATAGGCTGGTTCTCAACCGG AACCTCTCCATCTCGGAGAACCGCACCATGCAGCTGGCGGTGCTGGTCAATGACTCAGACTTCCAGGGCCCAGGAGCGGGCGTCCTCTTG CTCCACTTCAACGTGTCGGTGCTGCCGGTCAGCCTGCACCTGCCCAGTACCTACTCCCTCTCCGTGAGCAGGAGGGCTCGCCGATTTGCC CAGATCGGGAAAGTCTGTGTGGAAAACTGCCAGGCATTCAGTGGCATCAACGTCCAGTACAAGCTGCATTCCTCTGGTGCCAACTGCAGC ACGCTAGGGGTGGTCACCTCAGCCGAGGACACCTCGGGGATCCTGTTTGTGAATGACACCAAGGCCCTGCGGCGGCCCAAGTGTGCCGAA CTTCACTACATGGTGGTGGCCACCGACCAGCAGACCTCTAGGCAGGCCCAGGCCCAGCTGCTTGTAACAGTGGAGGGGTCATATGTGGCC GAGGAGGCGGGCTGCCCCCTGTCCTGTGCAGTCAGCAAGAGACGGCTGGAGTGTGAGGAGTGTGGCGGCCTGGGCTCCCCAACAGGCAGG TGTGAGTGGAGGCAAGGAGATGGCAAAGGGATCACCAGGAACTTCTCCACCTGCTCTCCCAGCACCAAGACCTGCCCCGACGGCCACTGC GATGTTGTGGAGACCCAAGACATCAACATTTGCCCTCAGGACTGCCTCCGGGGCAGCATTGTTGGGGGACACGAGCCTGGGGAGCCCCGG GGGATTAAAGCTGGCTATGGCACCTGCAACTGCTTCCCTGAGGAGGAGAAGTGCTTCTGCGAGCCCGAAGACATCCAGGATCCACTGTGC GACGAGCTGTGCCGCACGGTGATCGCAGCCGCTGTCCTCTTCTCCTTCATCGTCTCGGTGCTGCTGTCTGCCTTCTGCATCCACTGCTAC CACAAGTTTGCCCACAAGCCACCCATCTCCTCAGCTGAGATGACCTTCCGGAGGCCCGCCCAGGCCTTCCCGGTCAGCTACTCCTCTTCC GGTGCCCGCCGGCCCTCGCTGGACTCCATGGAGAACCAGGTCTCCGTGGATGCCTTCAAGATCCTGGATATGGAGGCACAGCAAGTTAAT GAAGCAGAATCAGCAAGAGAACAGTTACAGGATCTGCATGACCAAATAGCTGGGCAGAAAGCATCCAAACAAGAACTAGAGACAGAACTG GAGCGACTGAAGCAGGAGTTCCACTATATAGAAGAAGATCTTTATCGAACAAAGAACACATTGCAAAGCAGAATTAAAGATCGAGACGAA GAAATTCAAAAACTCAGGAATCAGCTTACCAATAAAACTTTAAGCAATAGCAGTCAGTCTGAGTTAGAAAATCGACTCCATCAGCTAACA GAGACTCTCATCCAGAAACAGACCATGCTGGAGAGTCTCAGCACAGAAAAGAACTCCCTGGTCTTTCAACTGGAGCGCCTCGAACAGCAG ATGAACTCCGCCTCTGGAAGTAGTAGTAATGGGTCTTCGATTAATATGTCTGGAATTGACAATGGTGAAGGCACTCGTCTGCGAAATGTT CCTGTTCTTTTTAATGACACAGAAACTAATCTGGCAGGAATGTACGGAAAAGTTCGCAAAGCTGCTAGTTCAATTGATCAGTTTAGGCTT TGCTTCACCTCTGGGTCATGATTGTTCTGTTGACTTACACACCAGAAATGCACCACGACCAACCATATGGCAAATGAACCAAGCCCAGTT GTTGCAGTGATTGGTTGTCTTTTTCTAGACTTGGGATCTGCAAGAAGGCCAATTGCCTAAAATTTCTGAGAACAGTGCACAAGATTATTT TATCACTACAAGCTTTTAACTTTTTAAGTTATTGTACAAGTATTCTACCTAAATCTTCCAATTTCCTTTAAATGGTAAGAGTTTCTAAAA CAGACAATAATTTAACAAGCTCAGCTCTGCTTTATCTGAGTTTAGTGGTCCTAATATATATGTAGAGAAAGATGGTGGGGTTGTTCACCT CTGTACAGACCATCTGTATGTTAGGTGACATTGATTATGGGTTATAATCAGGGAAACTAATTGTATTTAGTGACAAAAATAAAAAGTTTT TTTTTATAATTCAGTCTGCTTTTGGATTTTCATATATTTAACTTTGCAAAAAGATTTACTTTGTACATGTTACAGGCTTGATTGGTGTAA >73558_73558_2_RET-GOLGA5_RET_chr10_43610184_ENST00000340058_GOLGA5_chr14_93286052_ENST00000355976_length(amino acids)=906AA_BP=707 MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQE DTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENR PPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAP TFPAGVDTASAVVEFKRKEDTVVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNR NLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCS TLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGR CEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLC DELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILDMEAQQVN EAESAREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLT ETLIQKQTMLESLSTEKNSLVFQLERLEQQMNSASGSSSNGSSINMSGIDNGEGTRLRNVPVLFNDTETNLAGMYGKVRKAASSIDQFRL -------------------------------------------------------------- >73558_73558_3_RET-GOLGA5_RET_chr10_43610184_ENST00000355710_GOLGA5_chr14_93286052_ENST00000163416_length(transcript)=3590nt_BP=2368nt CCCTACCCGCTCCTCCGGCGCAGCCGGCGCTTACCTCGCTTCAGTCCCGCGACCGAAGCAGGGCGCGCAGCAGCGCTGAGTGCCCCGGAA CGTGCGTCGCGCCCCCAGTGTCCGTCGCGTCCGCCGCGCCCCGGGCGGGGATGGGGCGGCCAGACTGAGCGCCGCACCCGCCATCCAGAC CCGCCGGCCCTAGCCGCAGTCCCTCCAGCCGTGGCCCCAGCGCGCACGGGCGATGGCGAAGGCGACGTCCGGTGCCGCGGGGCTGCGTCT GCTGTTGCTGCTGCTGCTGCCGCTGCTAGGCAAAGTGGCATTGGGCCTCTACTTCTCGAGGGATGCTTACTGGGAGAAGCTGTATGTGGA CCAGGCAGCCGGCACGCCCTTGCTGTACGTCCATGCCCTGCGGGACGCCCCTGAGGAGGTGCCCAGCTTCCGCCTGGGCCAGCATCTCTA CGGCACGTACCGCACACGGCTGCATGAGAACAACTGGATCTGCATCCAGGAGGACACCGGCCTCCTCTACCTTAACCGGAGCCTGGACCA TAGCTCCTGGGAGAAGCTCAGTGTCCGCAACCGCGGCTTTCCCCTGCTCACCGTCTACCTCAAGGTCTTCCTGTCACCCACATCCCTTCG TGAGGGCGAGTGCCAGTGGCCAGGCTGTGCCCGCGTATACTTCTCCTTCTTCAACACCTCCTTTCCAGCCTGCAGCTCCCTCAAGCCCCG GGAGCTCTGCTTCCCAGAGACAAGGCCCTCCTTCCGCATTCGGGAGAACCGACCCCCAGGCACCTTCCACCAGTTCCGCCTGCTGCCTGT GCAGTTCTTGTGCCCCAACATCAGCGTGGCCTACAGGCTCCTGGAGGGTGAGGGTCTGCCCTTCCGCTGCGCCCCGGACAGCCTGGAGGT GAGCACGCGCTGGGCCCTGGACCGCGAGCAGCGGGAGAAGTACGAGCTGGTGGCCGTGTGCACCGTGCACGCCGGCGCGCGCGAGGAGGT GGTGATGGTGCCCTTCCCGGTGACCGTGTACGACGAGGACGACTCGGCGCCCACCTTCCCCGCGGGCGTCGACACCGCCAGCGCCGTGGT GGAGTTCAAGCGGAAGGAGGACACCGTGGTGGCCACGCTGCGTGTCTTCGATGCAGACGTGGTACCTGCATCAGGGGAGCTGGTGAGGCG GTACACAAGCACGCTGCTCCCCGGGGACACCTGGGCCCAGCAGACCTTCCGGGTGGAACACTGGCCCAACGAGACCTCGGTCCAGGCCAA CGGCAGCTTCGTGCGGGCGACCGTACATGACTATAGGCTGGTTCTCAACCGGAACCTCTCCATCTCGGAGAACCGCACCATGCAGCTGGC GGTGCTGGTCAATGACTCAGACTTCCAGGGCCCAGGAGCGGGCGTCCTCTTGCTCCACTTCAACGTGTCGGTGCTGCCGGTCAGCCTGCA CCTGCCCAGTACCTACTCCCTCTCCGTGAGCAGGAGGGCTCGCCGATTTGCCCAGATCGGGAAAGTCTGTGTGGAAAACTGCCAGGCATT CAGTGGCATCAACGTCCAGTACAAGCTGCATTCCTCTGGTGCCAACTGCAGCACGCTAGGGGTGGTCACCTCAGCCGAGGACACCTCGGG GATCCTGTTTGTGAATGACACCAAGGCCCTGCGGCGGCCCAAGTGTGCCGAACTTCACTACATGGTGGTGGCCACCGACCAGCAGACCTC TAGGCAGGCCCAGGCCCAGCTGCTTGTAACAGTGGAGGGGTCATATGTGGCCGAGGAGGCGGGCTGCCCCCTGTCCTGTGCAGTCAGCAA GAGACGGCTGGAGTGTGAGGAGTGTGGCGGCCTGGGCTCCCCAACAGGCAGGTGTGAGTGGAGGCAAGGAGATGGCAAAGGGATCACCAG GAACTTCTCCACCTGCTCTCCCAGCACCAAGACCTGCCCCGACGGCCACTGCGATGTTGTGGAGACCCAAGACATCAACATTTGCCCTCA GGACTGCCTCCGGGGCAGCATTGTTGGGGGACACGAGCCTGGGGAGCCCCGGGGGATTAAAGCTGGCTATGGCACCTGCAACTGCTTCCC TGAGGAGGAGAAGTGCTTCTGCGAGCCCGAAGACATCCAGGATCCACTGTGCGACGAGCTGTGCCGCACGGTGATCGCAGCCGCTGTCCT CTTCTCCTTCATCGTCTCGGTGCTGCTGTCTGCCTTCTGCATCCACTGCTACCACAAGTTTGCCCACAAGCCACCCATCTCCTCAGCTGA GATGACCTTCCGGAGGCCCGCCCAGGCCTTCCCGGTCAGCTACTCCTCTTCCGGTGCCCGCCGGCCCTCGCTGGACTCCATGGAGAACCA GGTCTCCGTGGATGCCTTCAAGATCCTGGATATGGAGGCACAGCAAGTTAATGAAGCAGAATCAGCAAGAGAACAGTTACAGGATCTGCA TGACCAAATAGCTGGGCAGAAAGCATCCAAACAAGAACTAGAGACAGAACTGGAGCGACTGAAGCAGGAGTTCCACTATATAGAAGAAGA TCTTTATCGAACAAAGAACACATTGCAAAGCAGAATTAAAGATCGAGACGAAGAAATTCAAAAACTCAGGAATCAGCTTACCAATAAAAC TTTAAGCAATAGCAGTCAGTCTGAGTTAGAAAATCGACTCCATCAGCTAACAGAGACTCTCATCCAGAAACAGACCATGCTGGAGAGTCT CAGCACAGAAAAGAACTCCCTGGTCTTTCAACTGGAGCGCCTCGAACAGCAGATGAACTCCGCCTCTGGAAGTAGTAGTAATGGGTCTTC GATTAATATGTCTGGAATTGACAATGGTGAAGGCACTCGTCTGCGAAATGTTCCTGTTCTTTTTAATGACACAGAAACTAATCTGGCAGG AATGTACGGAAAAGTTCGCAAAGCTGCTAGTTCAATTGATCAGTTTAGTATTCGCCTGGGAATTTTTCTCCGAAGATACCCCATAGCGCG AGTTTTTGTAATTATATATATGGCTTTGCTTCACCTCTGGGTCATGATTGTTCTGTTGACTTACACACCAGAAATGCACCACGACCAACC ATATGGCAAATGAACCAAGCCCAGTTGTTGCAGTGATTGGTTGTCTTTTTCTAGACTTGGGATCTGCAAGAAGGCCAATTGCCTAAAATT TCTGAGAACAGTGCACAAGATTATTTTATCACTACAAGCTTTTAACTTTTTAAGTTATTGTACAAGTATTCTACCTAAATCTTCCAATTT CCTTTAAATGGTAAGAGTTTCTAAAACAGACAATAATTTAACAAGCTCAGCTCTGCTTTATCTGAGTTTAGTGGTCCTAATATATATGTA GAGAAAGATGGTGGGGTTGTTCACCTCTGTACAGACCATCTGTATGTTAGGTGACATTGATTATGGGTTATAATCAGGGAAACTAATTGT ATTTAGTGACAAAAATAAAAAGTTTTTTTTTATAATTCAGTCTGCTTTTGGATTTTCATATATTTAACTTTGCAAAAAGATTTACTTTGT >73558_73558_3_RET-GOLGA5_RET_chr10_43610184_ENST00000355710_GOLGA5_chr14_93286052_ENST00000163416_length(amino acids)=946AA_BP=707 MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQE DTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENR PPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAP TFPAGVDTASAVVEFKRKEDTVVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNR NLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCS TLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGR CEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLC DELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILDMEAQQVN EAESAREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLT ETLIQKQTMLESLSTEKNSLVFQLERLEQQMNSASGSSSNGSSINMSGIDNGEGTRLRNVPVLFNDTETNLAGMYGKVRKAASSIDQFSI -------------------------------------------------------------- >73558_73558_4_RET-GOLGA5_RET_chr10_43610184_ENST00000355710_GOLGA5_chr14_93286052_ENST00000355976_length(transcript)=3522nt_BP=2368nt CCCTACCCGCTCCTCCGGCGCAGCCGGCGCTTACCTCGCTTCAGTCCCGCGACCGAAGCAGGGCGCGCAGCAGCGCTGAGTGCCCCGGAA CGTGCGTCGCGCCCCCAGTGTCCGTCGCGTCCGCCGCGCCCCGGGCGGGGATGGGGCGGCCAGACTGAGCGCCGCACCCGCCATCCAGAC CCGCCGGCCCTAGCCGCAGTCCCTCCAGCCGTGGCCCCAGCGCGCACGGGCGATGGCGAAGGCGACGTCCGGTGCCGCGGGGCTGCGTCT GCTGTTGCTGCTGCTGCTGCCGCTGCTAGGCAAAGTGGCATTGGGCCTCTACTTCTCGAGGGATGCTTACTGGGAGAAGCTGTATGTGGA CCAGGCAGCCGGCACGCCCTTGCTGTACGTCCATGCCCTGCGGGACGCCCCTGAGGAGGTGCCCAGCTTCCGCCTGGGCCAGCATCTCTA CGGCACGTACCGCACACGGCTGCATGAGAACAACTGGATCTGCATCCAGGAGGACACCGGCCTCCTCTACCTTAACCGGAGCCTGGACCA TAGCTCCTGGGAGAAGCTCAGTGTCCGCAACCGCGGCTTTCCCCTGCTCACCGTCTACCTCAAGGTCTTCCTGTCACCCACATCCCTTCG TGAGGGCGAGTGCCAGTGGCCAGGCTGTGCCCGCGTATACTTCTCCTTCTTCAACACCTCCTTTCCAGCCTGCAGCTCCCTCAAGCCCCG GGAGCTCTGCTTCCCAGAGACAAGGCCCTCCTTCCGCATTCGGGAGAACCGACCCCCAGGCACCTTCCACCAGTTCCGCCTGCTGCCTGT GCAGTTCTTGTGCCCCAACATCAGCGTGGCCTACAGGCTCCTGGAGGGTGAGGGTCTGCCCTTCCGCTGCGCCCCGGACAGCCTGGAGGT GAGCACGCGCTGGGCCCTGGACCGCGAGCAGCGGGAGAAGTACGAGCTGGTGGCCGTGTGCACCGTGCACGCCGGCGCGCGCGAGGAGGT GGTGATGGTGCCCTTCCCGGTGACCGTGTACGACGAGGACGACTCGGCGCCCACCTTCCCCGCGGGCGTCGACACCGCCAGCGCCGTGGT GGAGTTCAAGCGGAAGGAGGACACCGTGGTGGCCACGCTGCGTGTCTTCGATGCAGACGTGGTACCTGCATCAGGGGAGCTGGTGAGGCG GTACACAAGCACGCTGCTCCCCGGGGACACCTGGGCCCAGCAGACCTTCCGGGTGGAACACTGGCCCAACGAGACCTCGGTCCAGGCCAA CGGCAGCTTCGTGCGGGCGACCGTACATGACTATAGGCTGGTTCTCAACCGGAACCTCTCCATCTCGGAGAACCGCACCATGCAGCTGGC GGTGCTGGTCAATGACTCAGACTTCCAGGGCCCAGGAGCGGGCGTCCTCTTGCTCCACTTCAACGTGTCGGTGCTGCCGGTCAGCCTGCA CCTGCCCAGTACCTACTCCCTCTCCGTGAGCAGGAGGGCTCGCCGATTTGCCCAGATCGGGAAAGTCTGTGTGGAAAACTGCCAGGCATT CAGTGGCATCAACGTCCAGTACAAGCTGCATTCCTCTGGTGCCAACTGCAGCACGCTAGGGGTGGTCACCTCAGCCGAGGACACCTCGGG GATCCTGTTTGTGAATGACACCAAGGCCCTGCGGCGGCCCAAGTGTGCCGAACTTCACTACATGGTGGTGGCCACCGACCAGCAGACCTC TAGGCAGGCCCAGGCCCAGCTGCTTGTAACAGTGGAGGGGTCATATGTGGCCGAGGAGGCGGGCTGCCCCCTGTCCTGTGCAGTCAGCAA GAGACGGCTGGAGTGTGAGGAGTGTGGCGGCCTGGGCTCCCCAACAGGCAGGTGTGAGTGGAGGCAAGGAGATGGCAAAGGGATCACCAG GAACTTCTCCACCTGCTCTCCCAGCACCAAGACCTGCCCCGACGGCCACTGCGATGTTGTGGAGACCCAAGACATCAACATTTGCCCTCA GGACTGCCTCCGGGGCAGCATTGTTGGGGGACACGAGCCTGGGGAGCCCCGGGGGATTAAAGCTGGCTATGGCACCTGCAACTGCTTCCC TGAGGAGGAGAAGTGCTTCTGCGAGCCCGAAGACATCCAGGATCCACTGTGCGACGAGCTGTGCCGCACGGTGATCGCAGCCGCTGTCCT CTTCTCCTTCATCGTCTCGGTGCTGCTGTCTGCCTTCTGCATCCACTGCTACCACAAGTTTGCCCACAAGCCACCCATCTCCTCAGCTGA GATGACCTTCCGGAGGCCCGCCCAGGCCTTCCCGGTCAGCTACTCCTCTTCCGGTGCCCGCCGGCCCTCGCTGGACTCCATGGAGAACCA GGTCTCCGTGGATGCCTTCAAGATCCTGGATATGGAGGCACAGCAAGTTAATGAAGCAGAATCAGCAAGAGAACAGTTACAGGATCTGCA TGACCAAATAGCTGGGCAGAAAGCATCCAAACAAGAACTAGAGACAGAACTGGAGCGACTGAAGCAGGAGTTCCACTATATAGAAGAAGA TCTTTATCGAACAAAGAACACATTGCAAAGCAGAATTAAAGATCGAGACGAAGAAATTCAAAAACTCAGGAATCAGCTTACCAATAAAAC TTTAAGCAATAGCAGTCAGTCTGAGTTAGAAAATCGACTCCATCAGCTAACAGAGACTCTCATCCAGAAACAGACCATGCTGGAGAGTCT CAGCACAGAAAAGAACTCCCTGGTCTTTCAACTGGAGCGCCTCGAACAGCAGATGAACTCCGCCTCTGGAAGTAGTAGTAATGGGTCTTC GATTAATATGTCTGGAATTGACAATGGTGAAGGCACTCGTCTGCGAAATGTTCCTGTTCTTTTTAATGACACAGAAACTAATCTGGCAGG AATGTACGGAAAAGTTCGCAAAGCTGCTAGTTCAATTGATCAGTTTAGGCTTTGCTTCACCTCTGGGTCATGATTGTTCTGTTGACTTAC ACACCAGAAATGCACCACGACCAACCATATGGCAAATGAACCAAGCCCAGTTGTTGCAGTGATTGGTTGTCTTTTTCTAGACTTGGGATC TGCAAGAAGGCCAATTGCCTAAAATTTCTGAGAACAGTGCACAAGATTATTTTATCACTACAAGCTTTTAACTTTTTAAGTTATTGTACA AGTATTCTACCTAAATCTTCCAATTTCCTTTAAATGGTAAGAGTTTCTAAAACAGACAATAATTTAACAAGCTCAGCTCTGCTTTATCTG AGTTTAGTGGTCCTAATATATATGTAGAGAAAGATGGTGGGGTTGTTCACCTCTGTACAGACCATCTGTATGTTAGGTGACATTGATTAT GGGTTATAATCAGGGAAACTAATTGTATTTAGTGACAAAAATAAAAAGTTTTTTTTTATAATTCAGTCTGCTTTTGGATTTTCATATATT TAACTTTGCAAAAAGATTTACTTTGTACATGTTACAGGCTTGATTGGTGTAAATCTTTTTATAAATACATAAATAAAAGAAAAATATGCA >73558_73558_4_RET-GOLGA5_RET_chr10_43610184_ENST00000355710_GOLGA5_chr14_93286052_ENST00000355976_length(amino acids)=906AA_BP=707 MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQE DTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENR PPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAP TFPAGVDTASAVVEFKRKEDTVVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNR NLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCS TLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGR CEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLC DELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILDMEAQQVN EAESAREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLT ETLIQKQTMLESLSTEKNSLVFQLERLEQQMNSASGSSSNGSSINMSGIDNGEGTRLRNVPVLFNDTETNLAGMYGKVRKAASSIDQFRL -------------------------------------------------------------- |
Top |
Fusion Gene PPI Analysis for RET-GOLGA5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for RET-GOLGA5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for RET-GOLGA5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2021-Present -The University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information |Campus Carry|Site Policies