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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:REV1-LYG2 (FusionGDB2 ID:73574)

Fusion Gene Summary for REV1-LYG2

check button Fusion gene summary
Fusion gene informationFusion gene name: REV1-LYG2
Fusion gene ID: 73574
HgeneTgene
Gene symbol

REV1

LYG2

Gene ID

51455

254773

Gene nameREV1 DNA directed polymeraselysozyme g2
SynonymsAIBP80|REV1LLYGH|LYSG2
Cytomap

2q11.2

2q11.2

Type of geneprotein-codingprotein-coding
DescriptionDNA repair protein REV1REV1 homologREV1, polymerase (DNA directed)REV1- likealpha integrin-binding protein 80rev1-like terminal deoxycytidyl transferaselysozyme g-like protein 2lysozyme G-like 2
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000258428, ENST00000393445, 
ENST00000465835, 		ENST00000423800, 
ENST00000333017, ENST00000409238, 
ENST00000409679, 
Fusion gene scores* DoF score13 X 11 X 6=8583 X 2 X 3=18
# samples 134
** MAII scorelog2(13/858*10)=-2.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: REV1 [Title/Abstract] AND LYG2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointREV1(100078958)-LYG2(99863283), # samples:2
Anticipated loss of major functional domain due to fusion event.REV1-LYG2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneREV1

GO:0009411

response to UV

11485998

TgeneLYG2

GO:0042742

defense response to bacterium

21093056

TgeneLYG2

GO:0050830

defense response to Gram-positive bacterium

21093056


check buttonFusion gene breakpoints across REV1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LYG2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-FD-A5BZ-01AREV1chr2

100078958

-LYG2chr2

99863283

-
ChimerDB4BLCATCGA-FD-A5BZREV1chr2

100078957

-LYG2chr2

99863283

-


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Fusion Gene ORF analysis for REV1-LYG2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000258428ENST00000423800REV1chr2

100078958

-LYG2chr2

99863283

-
Frame-shiftENST00000258428ENST00000423800REV1chr2

100078957

-LYG2chr2

99863283

-
Frame-shiftENST00000393445ENST00000423800REV1chr2

100078958

-LYG2chr2

99863283

-
Frame-shiftENST00000393445ENST00000423800REV1chr2

100078957

-LYG2chr2

99863283

-
In-frameENST00000258428ENST00000333017REV1chr2

100078958

-LYG2chr2

99863283

-
In-frameENST00000258428ENST00000333017REV1chr2

100078957

-LYG2chr2

99863283

-
In-frameENST00000258428ENST00000409238REV1chr2

100078958

-LYG2chr2

99863283

-
In-frameENST00000258428ENST00000409238REV1chr2

100078957

-LYG2chr2

99863283

-
In-frameENST00000258428ENST00000409679REV1chr2

100078958

-LYG2chr2

99863283

-
In-frameENST00000258428ENST00000409679REV1chr2

100078957

-LYG2chr2

99863283

-
In-frameENST00000393445ENST00000333017REV1chr2

100078958

-LYG2chr2

99863283

-
In-frameENST00000393445ENST00000333017REV1chr2

100078957

-LYG2chr2

99863283

-
In-frameENST00000393445ENST00000409238REV1chr2

100078958

-LYG2chr2

99863283

-
In-frameENST00000393445ENST00000409238REV1chr2

100078957

-LYG2chr2

99863283

-
In-frameENST00000393445ENST00000409679REV1chr2

100078958

-LYG2chr2

99863283

-
In-frameENST00000393445ENST00000409679REV1chr2

100078957

-LYG2chr2

99863283

-
intron-3CDSENST00000465835ENST00000333017REV1chr2

100078958

-LYG2chr2

99863283

-
intron-3CDSENST00000465835ENST00000333017REV1chr2

100078957

-LYG2chr2

99863283

-
intron-3CDSENST00000465835ENST00000409238REV1chr2

100078958

-LYG2chr2

99863283

-
intron-3CDSENST00000465835ENST00000409238REV1chr2

100078957

-LYG2chr2

99863283

-
intron-3CDSENST00000465835ENST00000409679REV1chr2

100078958

-LYG2chr2

99863283

-
intron-3CDSENST00000465835ENST00000409679REV1chr2

100078957

-LYG2chr2

99863283

-
intron-3CDSENST00000465835ENST00000423800REV1chr2

100078958

-LYG2chr2

99863283

-
intron-3CDSENST00000465835ENST00000423800REV1chr2

100078957

-LYG2chr2

99863283

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000393445REV1chr2100078958-ENST00000409238LYG2chr299863283-106234835943302
ENST00000393445REV1chr2100078958-ENST00000333017LYG2chr299863283-105434835943302
ENST00000393445REV1chr2100078958-ENST00000409679LYG2chr299863283-103834835853272
ENST00000258428REV1chr2100078958-ENST00000409238LYG2chr299863283-1124410431005320
ENST00000258428REV1chr2100078958-ENST00000333017LYG2chr299863283-1116410431005320
ENST00000258428REV1chr2100078958-ENST00000409679LYG2chr299863283-110041043915290
ENST00000393445REV1chr2100078957-ENST00000409238LYG2chr299863283-106234835943302
ENST00000393445REV1chr2100078957-ENST00000333017LYG2chr299863283-105434835943302
ENST00000393445REV1chr2100078957-ENST00000409679LYG2chr299863283-103834835853272
ENST00000258428REV1chr2100078957-ENST00000409238LYG2chr299863283-1124410431005320
ENST00000258428REV1chr2100078957-ENST00000333017LYG2chr299863283-1116410431005320
ENST00000258428REV1chr2100078957-ENST00000409679LYG2chr299863283-110041043915290

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000393445ENST00000409238REV1chr2100078958-LYG2chr299863283-0.0093941790.9906059
ENST00000393445ENST00000333017REV1chr2100078958-LYG2chr299863283-0.0097346510.9902653
ENST00000393445ENST00000409679REV1chr2100078958-LYG2chr299863283-0.0119276330.9880724
ENST00000258428ENST00000409238REV1chr2100078958-LYG2chr299863283-0.0097514810.9902485
ENST00000258428ENST00000333017REV1chr2100078958-LYG2chr299863283-0.0101328880.9898671
ENST00000258428ENST00000409679REV1chr2100078958-LYG2chr299863283-0.0137151390.98628485
ENST00000393445ENST00000409238REV1chr2100078957-LYG2chr299863283-0.0093941790.9906059
ENST00000393445ENST00000333017REV1chr2100078957-LYG2chr299863283-0.0097346510.9902653
ENST00000393445ENST00000409679REV1chr2100078957-LYG2chr299863283-0.0119276330.9880724
ENST00000258428ENST00000409238REV1chr2100078957-LYG2chr299863283-0.0097514810.9902485
ENST00000258428ENST00000333017REV1chr2100078957-LYG2chr299863283-0.0101328880.9898671
ENST00000258428ENST00000409679REV1chr2100078957-LYG2chr299863283-0.0137151390.98628485

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Fusion Genomic Features for REV1-LYG2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for REV1-LYG2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:100078958/chr2:99863283)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneREV1chr2:100078957chr2:99863283ENST00000258428-323419_653601252.0DomainUmuC
HgeneREV1chr2:100078957chr2:99863283ENST00000258428-32344_131601252.0DomainBRCT
HgeneREV1chr2:100078957chr2:99863283ENST00000393445-323419_653601251.0DomainUmuC
HgeneREV1chr2:100078957chr2:99863283ENST00000393445-32344_131601251.0DomainBRCT
HgeneREV1chr2:100078958chr2:99863283ENST00000258428-323419_653601252.0DomainUmuC
HgeneREV1chr2:100078958chr2:99863283ENST00000258428-32344_131601252.0DomainBRCT
HgeneREV1chr2:100078958chr2:99863283ENST00000393445-323419_653601251.0DomainUmuC
HgeneREV1chr2:100078958chr2:99863283ENST00000393445-32344_131601251.0DomainBRCT
HgeneREV1chr2:100078957chr2:99863283ENST00000258428-3231071_1078601252.0MotifNuclear localization signal
HgeneREV1chr2:100078957chr2:99863283ENST00000393445-3231071_1078601251.0MotifNuclear localization signal
HgeneREV1chr2:100078958chr2:99863283ENST00000258428-3231071_1078601252.0MotifNuclear localization signal
HgeneREV1chr2:100078958chr2:99863283ENST00000393445-3231071_1078601251.0MotifNuclear localization signal
HgeneREV1chr2:100078957chr2:99863283ENST00000258428-323423_427601252.0Nucleotide bindingdCTP binding
HgeneREV1chr2:100078957chr2:99863283ENST00000258428-323510_516601252.0Nucleotide bindingdCTP binding
HgeneREV1chr2:100078957chr2:99863283ENST00000393445-323423_427601251.0Nucleotide bindingdCTP binding
HgeneREV1chr2:100078957chr2:99863283ENST00000393445-323510_516601251.0Nucleotide bindingdCTP binding
HgeneREV1chr2:100078958chr2:99863283ENST00000258428-323423_427601252.0Nucleotide bindingdCTP binding
HgeneREV1chr2:100078958chr2:99863283ENST00000258428-323510_516601252.0Nucleotide bindingdCTP binding
HgeneREV1chr2:100078958chr2:99863283ENST00000393445-323423_427601251.0Nucleotide bindingdCTP binding
HgeneREV1chr2:100078958chr2:99863283ENST00000393445-323510_516601251.0Nucleotide bindingdCTP binding


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Fusion Gene Sequence for REV1-LYG2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>73574_73574_1_REV1-LYG2_REV1_chr2_100078957_ENST00000258428_LYG2_chr2_99863283_ENST00000333017_length(transcript)=1116nt_BP=410nt
CGGAGGGGGAGGGGCGGAGAGCCACCGCGGAGCGCGCGCGGGGTTGGTTGCCGCGAGCGTGGGGGAGCGTGGACCGCGGCGCTGCTCAGC
GGTGGGGCTGCCTTCCCCCGGCCCTCCTCCCTGGTCCCTGGCGAGGGCACTGGCGGCGGCGGGGCCGGGGTCCGCAAGGCCGGAGAAGGC
CGCCGGGCCCGGGCATGGTGGTCTGGGGCAACGCGGAAGAAGCTCCACCATGAGGCGAGGTGGATGGAGGAAGCGAGCTGAAAATGATGG
CTGGGAAACATGGGGTGGGTATATGGCTGCCAAGGTCCAGAAATTGGAGGAACAGTTTCGATCAGATGCTGCTATGCAGAAGGATGGGAC
TTCATCTACAATTTTTAGTGGAGTTGCCATCTATGTTAATGGATACACAGGCACTTCCAGGGGCTCATACCCCTTCAGTCACTCAATGAA
GCCTCACCTACATCCACGCCTGTACCACGGCTGCTATGGGGACATCATGACCATGAAGACCTCTGGGGCCACTTGTGATGCAAACAGTGT
GATGAACTGCGGGATCCGTGGTTCTGAAATGTTTGCTGAGATGGATTTGAGGGCCATAAAACCTTACCAGACTCTGATCAAAGAAGTCGG
GCAGAGACATTGCGTGGACCCTGCTGTCATCGCAGCCATCATCTCCAGGGAAAGCCATGGCGGATCTGTCCTGCAAGACGGCTGGGACCA
CAGGGGACTTAAATTTGGCTTGATGCAGCTTGATAAACAAACGTACCACCCTGTCGGTGCCTGGGATAGCAAAGAGCACCTTTCACAGGC
TACTGGGATTCTAACAGAGAGAATTAAGGCAATCCAGAAAAAATTCCCCACGTGGAGTGTTGCTCAGCACCTCAAAGGTGGTCTCTCAGC
TTTTAAGTCAGGAATTGAAGCGATTGCCACCCCATCGGACATAGACAATGACTTCGTCAATGATATCATTGCTCGAGCTAAGTTCTATAA
AAGACAAAGCTTCTAGGCAAAGCTCTGTGGGTGGGCCAGGTTGGCAGAGTGCTCAGATGGCCGCCTTTGAGAGTTTTACGTGAATGTGTT

>73574_73574_1_REV1-LYG2_REV1_chr2_100078957_ENST00000258428_LYG2_chr2_99863283_ENST00000333017_length(amino acids)=320AA_BP=1
MVAASVGERGPRRCSAVGLPSPGPPPWSLARALAAAGPGSARPEKAAGPGHGGLGQRGRSSTMRRGGWRKRAENDGWETWGGYMAAKVQK
LEEQFRSDAAMQKDGTSSTIFSGVAIYVNGYTGTSRGSYPFSHSMKPHLHPRLYHGCYGDIMTMKTSGATCDANSVMNCGIRGSEMFAEM
DLRAIKPYQTLIKEVGQRHCVDPAVIAAIISRESHGGSVLQDGWDHRGLKFGLMQLDKQTYHPVGAWDSKEHLSQATGILTERIKAIQKK

--------------------------------------------------------------
>73574_73574_2_REV1-LYG2_REV1_chr2_100078957_ENST00000258428_LYG2_chr2_99863283_ENST00000409238_length(transcript)=1124nt_BP=410nt
CGGAGGGGGAGGGGCGGAGAGCCACCGCGGAGCGCGCGCGGGGTTGGTTGCCGCGAGCGTGGGGGAGCGTGGACCGCGGCGCTGCTCAGC
GGTGGGGCTGCCTTCCCCCGGCCCTCCTCCCTGGTCCCTGGCGAGGGCACTGGCGGCGGCGGGGCCGGGGTCCGCAAGGCCGGAGAAGGC
CGCCGGGCCCGGGCATGGTGGTCTGGGGCAACGCGGAAGAAGCTCCACCATGAGGCGAGGTGGATGGAGGAAGCGAGCTGAAAATGATGG
CTGGGAAACATGGGGTGGGTATATGGCTGCCAAGGTCCAGAAATTGGAGGAACAGTTTCGATCAGATGCTGCTATGCAGAAGGATGGGAC
TTCATCTACAATTTTTAGTGGAGTTGCCATCTATGTTAATGGATACACAGGCACTTCCAGGGGCTCATACCCCTTCAGTCACTCAATGAA
GCCTCACCTACATCCACGCCTGTACCACGGCTGCTATGGGGACATCATGACCATGAAGACCTCTGGGGCCACTTGTGATGCAAACAGTGT
GATGAACTGCGGGATCCGTGGTTCTGAAATGTTTGCTGAGATGGATTTGAGGGCCATAAAACCTTACCAGACTCTGATCAAAGAAGTCGG
GCAGAGACATTGCGTGGACCCTGCTGTCATCGCAGCCATCATCTCCAGGGAAAGCCATGGCGGATCTGTCCTGCAAGACGGCTGGGACCA
CAGGGGACTTAAATTTGGCTTGATGCAGCTTGATAAACAAACGTACCACCCTGTCGGTGCCTGGGATAGCAAAGAGCACCTTTCACAGGC
TACTGGGATTCTAACAGAGAGAATTAAGGCAATCCAGAAAAAATTCCCCACGTGGAGTGTTGCTCAGCACCTCAAAGGTGGTCTCTCAGC
TTTTAAGTCAGGAATTGAAGCGATTGCCACCCCATCGGACATAGACAATGACTTCGTCAATGATATCATTGCTCGAGCTAAGTTCTATAA
AAGACAAAGCTTCTAGGCAAAGCTCTGTGGGTGGGCCAGGTTGGCAGAGTGCTCAGATGGCCGCCTTTGAGAGTTTTACGTGAATGTGTT

>73574_73574_2_REV1-LYG2_REV1_chr2_100078957_ENST00000258428_LYG2_chr2_99863283_ENST00000409238_length(amino acids)=320AA_BP=1
MVAASVGERGPRRCSAVGLPSPGPPPWSLARALAAAGPGSARPEKAAGPGHGGLGQRGRSSTMRRGGWRKRAENDGWETWGGYMAAKVQK
LEEQFRSDAAMQKDGTSSTIFSGVAIYVNGYTGTSRGSYPFSHSMKPHLHPRLYHGCYGDIMTMKTSGATCDANSVMNCGIRGSEMFAEM
DLRAIKPYQTLIKEVGQRHCVDPAVIAAIISRESHGGSVLQDGWDHRGLKFGLMQLDKQTYHPVGAWDSKEHLSQATGILTERIKAIQKK

--------------------------------------------------------------
>73574_73574_3_REV1-LYG2_REV1_chr2_100078957_ENST00000258428_LYG2_chr2_99863283_ENST00000409679_length(transcript)=1100nt_BP=410nt
CGGAGGGGGAGGGGCGGAGAGCCACCGCGGAGCGCGCGCGGGGTTGGTTGCCGCGAGCGTGGGGGAGCGTGGACCGCGGCGCTGCTCAGC
GGTGGGGCTGCCTTCCCCCGGCCCTCCTCCCTGGTCCCTGGCGAGGGCACTGGCGGCGGCGGGGCCGGGGTCCGCAAGGCCGGAGAAGGC
CGCCGGGCCCGGGCATGGTGGTCTGGGGCAACGCGGAAGAAGCTCCACCATGAGGCGAGGTGGATGGAGGAAGCGAGCTGAAAATGATGG
CTGGGAAACATGGGGTGGGTATATGGCTGCCAAGGTCCAGAAATTGGAGGAACAGTTTCGATCAGATGCTGCTATGCAGAAGGATGGGAC
TTCATCTACAATTTTTAGTGGAGTTGCCATCTATGTTAATGGATACACAGGCACTTCCAGGGGCTCATACCCCTTCAGTCACTCAATGAA
GCCTCACCTACATCCACGCCTGTACCACGGCTGCTATGGGGACATCATGACCATGAAGACCTCTGGGGCCACTTGTGATGCAAACAGTGT
GATGAACTGCGGGATCCGTGGTTCTGAAATGTTTGCTGAGATGGATTTGAGGGCCATAAAACCTTACCAGACTCTGATCAAAGAAGTCGG
GCAGAGACATTGCGTGGACCCTGCTGTCATCGCAGCCATCATCTCCAGGGAAAGCCATGGCGGATCTGTCCTGCAAGACGGCTGGGACCA
CAGGGGACTTAAATTTGGCTTGATGCAGCTTGATAAACAAACGTACCACCCTGTCGGTGCCTGGGATAGCAAAGAGCACCTTTCACAGGC
TACTGGGATTCTAACAGAGAGAATTAAGGCAATCCAGAAAAAATTCCCCACGTGGAGTGTTGCTCAGCACCTCAAAGGTAGGCTGTATTC
TGAGTACTTTGTTTAAATGAGCAATGAATGAGACCACTGAAGGCCAGTGTGACCCGAGACTCCCTGGGAGCATTTCCACGGGGTCAGCAG
TGGCCCTGGGAGGAGCTGTCTAGAGGCTGCATTTGCATTCCCTGAACCACTGAGTTACTTTGAGAGGTCCTCCATCCTCAACCTCCATTT

>73574_73574_3_REV1-LYG2_REV1_chr2_100078957_ENST00000258428_LYG2_chr2_99863283_ENST00000409679_length(amino acids)=290AA_BP=1
MVAASVGERGPRRCSAVGLPSPGPPPWSLARALAAAGPGSARPEKAAGPGHGGLGQRGRSSTMRRGGWRKRAENDGWETWGGYMAAKVQK
LEEQFRSDAAMQKDGTSSTIFSGVAIYVNGYTGTSRGSYPFSHSMKPHLHPRLYHGCYGDIMTMKTSGATCDANSVMNCGIRGSEMFAEM
DLRAIKPYQTLIKEVGQRHCVDPAVIAAIISRESHGGSVLQDGWDHRGLKFGLMQLDKQTYHPVGAWDSKEHLSQATGILTERIKAIQKK

--------------------------------------------------------------
>73574_73574_4_REV1-LYG2_REV1_chr2_100078957_ENST00000393445_LYG2_chr2_99863283_ENST00000333017_length(transcript)=1054nt_BP=348nt
GGGAGCGTGGACCGCGGCGCTGCTCAGCGGTGGGGCTGCCTTCCCCCGGCCCTCCTCCCTGGTCCCTGGCGAGGGCACTGGCGGCGGCGG
GGCCGGGGTCCGCAAGGCCGGAGAAGGCCGCCGGGCCCGGGCATGGTGGTCTGGGGCAACGCGGAAGAAGCTCCACCATGAGGCGAGGTG
GATGGAGGAAGCGAGCTGAAAATGATGGCTGGGAAACATGGGGTGGGTATATGGCTGCCAAGGTCCAGAAATTGGAGGAACAGTTTCGAT
CAGATGCTGCTATGCAGAAGGATGGGACTTCATCTACAATTTTTAGTGGAGTTGCCATCTATGTTAATGGATACACAGGCACTTCCAGGG
GCTCATACCCCTTCAGTCACTCAATGAAGCCTCACCTACATCCACGCCTGTACCACGGCTGCTATGGGGACATCATGACCATGAAGACCT
CTGGGGCCACTTGTGATGCAAACAGTGTGATGAACTGCGGGATCCGTGGTTCTGAAATGTTTGCTGAGATGGATTTGAGGGCCATAAAAC
CTTACCAGACTCTGATCAAAGAAGTCGGGCAGAGACATTGCGTGGACCCTGCTGTCATCGCAGCCATCATCTCCAGGGAAAGCCATGGCG
GATCTGTCCTGCAAGACGGCTGGGACCACAGGGGACTTAAATTTGGCTTGATGCAGCTTGATAAACAAACGTACCACCCTGTCGGTGCCT
GGGATAGCAAAGAGCACCTTTCACAGGCTACTGGGATTCTAACAGAGAGAATTAAGGCAATCCAGAAAAAATTCCCCACGTGGAGTGTTG
CTCAGCACCTCAAAGGTGGTCTCTCAGCTTTTAAGTCAGGAATTGAAGCGATTGCCACCCCATCGGACATAGACAATGACTTCGTCAATG
ATATCATTGCTCGAGCTAAGTTCTATAAAAGACAAAGCTTCTAGGCAAAGCTCTGTGGGTGGGCCAGGTTGGCAGAGTGCTCAGATGGCC

>73574_73574_4_REV1-LYG2_REV1_chr2_100078957_ENST00000393445_LYG2_chr2_99863283_ENST00000333017_length(amino acids)=302AA_BP=1
MPSPGPPPWSLARALAAAGPGSARPEKAAGPGHGGLGQRGRSSTMRRGGWRKRAENDGWETWGGYMAAKVQKLEEQFRSDAAMQKDGTSS
TIFSGVAIYVNGYTGTSRGSYPFSHSMKPHLHPRLYHGCYGDIMTMKTSGATCDANSVMNCGIRGSEMFAEMDLRAIKPYQTLIKEVGQR
HCVDPAVIAAIISRESHGGSVLQDGWDHRGLKFGLMQLDKQTYHPVGAWDSKEHLSQATGILTERIKAIQKKFPTWSVAQHLKGGLSAFK

--------------------------------------------------------------
>73574_73574_5_REV1-LYG2_REV1_chr2_100078957_ENST00000393445_LYG2_chr2_99863283_ENST00000409238_length(transcript)=1062nt_BP=348nt
GGGAGCGTGGACCGCGGCGCTGCTCAGCGGTGGGGCTGCCTTCCCCCGGCCCTCCTCCCTGGTCCCTGGCGAGGGCACTGGCGGCGGCGG
GGCCGGGGTCCGCAAGGCCGGAGAAGGCCGCCGGGCCCGGGCATGGTGGTCTGGGGCAACGCGGAAGAAGCTCCACCATGAGGCGAGGTG
GATGGAGGAAGCGAGCTGAAAATGATGGCTGGGAAACATGGGGTGGGTATATGGCTGCCAAGGTCCAGAAATTGGAGGAACAGTTTCGAT
CAGATGCTGCTATGCAGAAGGATGGGACTTCATCTACAATTTTTAGTGGAGTTGCCATCTATGTTAATGGATACACAGGCACTTCCAGGG
GCTCATACCCCTTCAGTCACTCAATGAAGCCTCACCTACATCCACGCCTGTACCACGGCTGCTATGGGGACATCATGACCATGAAGACCT
CTGGGGCCACTTGTGATGCAAACAGTGTGATGAACTGCGGGATCCGTGGTTCTGAAATGTTTGCTGAGATGGATTTGAGGGCCATAAAAC
CTTACCAGACTCTGATCAAAGAAGTCGGGCAGAGACATTGCGTGGACCCTGCTGTCATCGCAGCCATCATCTCCAGGGAAAGCCATGGCG
GATCTGTCCTGCAAGACGGCTGGGACCACAGGGGACTTAAATTTGGCTTGATGCAGCTTGATAAACAAACGTACCACCCTGTCGGTGCCT
GGGATAGCAAAGAGCACCTTTCACAGGCTACTGGGATTCTAACAGAGAGAATTAAGGCAATCCAGAAAAAATTCCCCACGTGGAGTGTTG
CTCAGCACCTCAAAGGTGGTCTCTCAGCTTTTAAGTCAGGAATTGAAGCGATTGCCACCCCATCGGACATAGACAATGACTTCGTCAATG
ATATCATTGCTCGAGCTAAGTTCTATAAAAGACAAAGCTTCTAGGCAAAGCTCTGTGGGTGGGCCAGGTTGGCAGAGTGCTCAGATGGCC

>73574_73574_5_REV1-LYG2_REV1_chr2_100078957_ENST00000393445_LYG2_chr2_99863283_ENST00000409238_length(amino acids)=302AA_BP=1
MPSPGPPPWSLARALAAAGPGSARPEKAAGPGHGGLGQRGRSSTMRRGGWRKRAENDGWETWGGYMAAKVQKLEEQFRSDAAMQKDGTSS
TIFSGVAIYVNGYTGTSRGSYPFSHSMKPHLHPRLYHGCYGDIMTMKTSGATCDANSVMNCGIRGSEMFAEMDLRAIKPYQTLIKEVGQR
HCVDPAVIAAIISRESHGGSVLQDGWDHRGLKFGLMQLDKQTYHPVGAWDSKEHLSQATGILTERIKAIQKKFPTWSVAQHLKGGLSAFK

--------------------------------------------------------------
>73574_73574_6_REV1-LYG2_REV1_chr2_100078957_ENST00000393445_LYG2_chr2_99863283_ENST00000409679_length(transcript)=1038nt_BP=348nt
GGGAGCGTGGACCGCGGCGCTGCTCAGCGGTGGGGCTGCCTTCCCCCGGCCCTCCTCCCTGGTCCCTGGCGAGGGCACTGGCGGCGGCGG
GGCCGGGGTCCGCAAGGCCGGAGAAGGCCGCCGGGCCCGGGCATGGTGGTCTGGGGCAACGCGGAAGAAGCTCCACCATGAGGCGAGGTG
GATGGAGGAAGCGAGCTGAAAATGATGGCTGGGAAACATGGGGTGGGTATATGGCTGCCAAGGTCCAGAAATTGGAGGAACAGTTTCGAT
CAGATGCTGCTATGCAGAAGGATGGGACTTCATCTACAATTTTTAGTGGAGTTGCCATCTATGTTAATGGATACACAGGCACTTCCAGGG
GCTCATACCCCTTCAGTCACTCAATGAAGCCTCACCTACATCCACGCCTGTACCACGGCTGCTATGGGGACATCATGACCATGAAGACCT
CTGGGGCCACTTGTGATGCAAACAGTGTGATGAACTGCGGGATCCGTGGTTCTGAAATGTTTGCTGAGATGGATTTGAGGGCCATAAAAC
CTTACCAGACTCTGATCAAAGAAGTCGGGCAGAGACATTGCGTGGACCCTGCTGTCATCGCAGCCATCATCTCCAGGGAAAGCCATGGCG
GATCTGTCCTGCAAGACGGCTGGGACCACAGGGGACTTAAATTTGGCTTGATGCAGCTTGATAAACAAACGTACCACCCTGTCGGTGCCT
GGGATAGCAAAGAGCACCTTTCACAGGCTACTGGGATTCTAACAGAGAGAATTAAGGCAATCCAGAAAAAATTCCCCACGTGGAGTGTTG
CTCAGCACCTCAAAGGTAGGCTGTATTCTGAGTACTTTGTTTAAATGAGCAATGAATGAGACCACTGAAGGCCAGTGTGACCCGAGACTC
CCTGGGAGCATTTCCACGGGGTCAGCAGTGGCCCTGGGAGGAGCTGTCTAGAGGCTGCATTTGCATTCCCTGAACCACTGAGTTACTTTG

>73574_73574_6_REV1-LYG2_REV1_chr2_100078957_ENST00000393445_LYG2_chr2_99863283_ENST00000409679_length(amino acids)=272AA_BP=1
MPSPGPPPWSLARALAAAGPGSARPEKAAGPGHGGLGQRGRSSTMRRGGWRKRAENDGWETWGGYMAAKVQKLEEQFRSDAAMQKDGTSS
TIFSGVAIYVNGYTGTSRGSYPFSHSMKPHLHPRLYHGCYGDIMTMKTSGATCDANSVMNCGIRGSEMFAEMDLRAIKPYQTLIKEVGQR
HCVDPAVIAAIISRESHGGSVLQDGWDHRGLKFGLMQLDKQTYHPVGAWDSKEHLSQATGILTERIKAIQKKFPTWSVAQHLKGRLYSEY

--------------------------------------------------------------
>73574_73574_7_REV1-LYG2_REV1_chr2_100078958_ENST00000258428_LYG2_chr2_99863283_ENST00000333017_length(transcript)=1116nt_BP=410nt
CGGAGGGGGAGGGGCGGAGAGCCACCGCGGAGCGCGCGCGGGGTTGGTTGCCGCGAGCGTGGGGGAGCGTGGACCGCGGCGCTGCTCAGC
GGTGGGGCTGCCTTCCCCCGGCCCTCCTCCCTGGTCCCTGGCGAGGGCACTGGCGGCGGCGGGGCCGGGGTCCGCAAGGCCGGAGAAGGC
CGCCGGGCCCGGGCATGGTGGTCTGGGGCAACGCGGAAGAAGCTCCACCATGAGGCGAGGTGGATGGAGGAAGCGAGCTGAAAATGATGG
CTGGGAAACATGGGGTGGGTATATGGCTGCCAAGGTCCAGAAATTGGAGGAACAGTTTCGATCAGATGCTGCTATGCAGAAGGATGGGAC
TTCATCTACAATTTTTAGTGGAGTTGCCATCTATGTTAATGGATACACAGGCACTTCCAGGGGCTCATACCCCTTCAGTCACTCAATGAA
GCCTCACCTACATCCACGCCTGTACCACGGCTGCTATGGGGACATCATGACCATGAAGACCTCTGGGGCCACTTGTGATGCAAACAGTGT
GATGAACTGCGGGATCCGTGGTTCTGAAATGTTTGCTGAGATGGATTTGAGGGCCATAAAACCTTACCAGACTCTGATCAAAGAAGTCGG
GCAGAGACATTGCGTGGACCCTGCTGTCATCGCAGCCATCATCTCCAGGGAAAGCCATGGCGGATCTGTCCTGCAAGACGGCTGGGACCA
CAGGGGACTTAAATTTGGCTTGATGCAGCTTGATAAACAAACGTACCACCCTGTCGGTGCCTGGGATAGCAAAGAGCACCTTTCACAGGC
TACTGGGATTCTAACAGAGAGAATTAAGGCAATCCAGAAAAAATTCCCCACGTGGAGTGTTGCTCAGCACCTCAAAGGTGGTCTCTCAGC
TTTTAAGTCAGGAATTGAAGCGATTGCCACCCCATCGGACATAGACAATGACTTCGTCAATGATATCATTGCTCGAGCTAAGTTCTATAA
AAGACAAAGCTTCTAGGCAAAGCTCTGTGGGTGGGCCAGGTTGGCAGAGTGCTCAGATGGCCGCCTTTGAGAGTTTTACGTGAATGTGTT

>73574_73574_7_REV1-LYG2_REV1_chr2_100078958_ENST00000258428_LYG2_chr2_99863283_ENST00000333017_length(amino acids)=320AA_BP=1
MVAASVGERGPRRCSAVGLPSPGPPPWSLARALAAAGPGSARPEKAAGPGHGGLGQRGRSSTMRRGGWRKRAENDGWETWGGYMAAKVQK
LEEQFRSDAAMQKDGTSSTIFSGVAIYVNGYTGTSRGSYPFSHSMKPHLHPRLYHGCYGDIMTMKTSGATCDANSVMNCGIRGSEMFAEM
DLRAIKPYQTLIKEVGQRHCVDPAVIAAIISRESHGGSVLQDGWDHRGLKFGLMQLDKQTYHPVGAWDSKEHLSQATGILTERIKAIQKK

--------------------------------------------------------------
>73574_73574_8_REV1-LYG2_REV1_chr2_100078958_ENST00000258428_LYG2_chr2_99863283_ENST00000409238_length(transcript)=1124nt_BP=410nt
CGGAGGGGGAGGGGCGGAGAGCCACCGCGGAGCGCGCGCGGGGTTGGTTGCCGCGAGCGTGGGGGAGCGTGGACCGCGGCGCTGCTCAGC
GGTGGGGCTGCCTTCCCCCGGCCCTCCTCCCTGGTCCCTGGCGAGGGCACTGGCGGCGGCGGGGCCGGGGTCCGCAAGGCCGGAGAAGGC
CGCCGGGCCCGGGCATGGTGGTCTGGGGCAACGCGGAAGAAGCTCCACCATGAGGCGAGGTGGATGGAGGAAGCGAGCTGAAAATGATGG
CTGGGAAACATGGGGTGGGTATATGGCTGCCAAGGTCCAGAAATTGGAGGAACAGTTTCGATCAGATGCTGCTATGCAGAAGGATGGGAC
TTCATCTACAATTTTTAGTGGAGTTGCCATCTATGTTAATGGATACACAGGCACTTCCAGGGGCTCATACCCCTTCAGTCACTCAATGAA
GCCTCACCTACATCCACGCCTGTACCACGGCTGCTATGGGGACATCATGACCATGAAGACCTCTGGGGCCACTTGTGATGCAAACAGTGT
GATGAACTGCGGGATCCGTGGTTCTGAAATGTTTGCTGAGATGGATTTGAGGGCCATAAAACCTTACCAGACTCTGATCAAAGAAGTCGG
GCAGAGACATTGCGTGGACCCTGCTGTCATCGCAGCCATCATCTCCAGGGAAAGCCATGGCGGATCTGTCCTGCAAGACGGCTGGGACCA
CAGGGGACTTAAATTTGGCTTGATGCAGCTTGATAAACAAACGTACCACCCTGTCGGTGCCTGGGATAGCAAAGAGCACCTTTCACAGGC
TACTGGGATTCTAACAGAGAGAATTAAGGCAATCCAGAAAAAATTCCCCACGTGGAGTGTTGCTCAGCACCTCAAAGGTGGTCTCTCAGC
TTTTAAGTCAGGAATTGAAGCGATTGCCACCCCATCGGACATAGACAATGACTTCGTCAATGATATCATTGCTCGAGCTAAGTTCTATAA
AAGACAAAGCTTCTAGGCAAAGCTCTGTGGGTGGGCCAGGTTGGCAGAGTGCTCAGATGGCCGCCTTTGAGAGTTTTACGTGAATGTGTT

>73574_73574_8_REV1-LYG2_REV1_chr2_100078958_ENST00000258428_LYG2_chr2_99863283_ENST00000409238_length(amino acids)=320AA_BP=1
MVAASVGERGPRRCSAVGLPSPGPPPWSLARALAAAGPGSARPEKAAGPGHGGLGQRGRSSTMRRGGWRKRAENDGWETWGGYMAAKVQK
LEEQFRSDAAMQKDGTSSTIFSGVAIYVNGYTGTSRGSYPFSHSMKPHLHPRLYHGCYGDIMTMKTSGATCDANSVMNCGIRGSEMFAEM
DLRAIKPYQTLIKEVGQRHCVDPAVIAAIISRESHGGSVLQDGWDHRGLKFGLMQLDKQTYHPVGAWDSKEHLSQATGILTERIKAIQKK

--------------------------------------------------------------
>73574_73574_9_REV1-LYG2_REV1_chr2_100078958_ENST00000258428_LYG2_chr2_99863283_ENST00000409679_length(transcript)=1100nt_BP=410nt
CGGAGGGGGAGGGGCGGAGAGCCACCGCGGAGCGCGCGCGGGGTTGGTTGCCGCGAGCGTGGGGGAGCGTGGACCGCGGCGCTGCTCAGC
GGTGGGGCTGCCTTCCCCCGGCCCTCCTCCCTGGTCCCTGGCGAGGGCACTGGCGGCGGCGGGGCCGGGGTCCGCAAGGCCGGAGAAGGC
CGCCGGGCCCGGGCATGGTGGTCTGGGGCAACGCGGAAGAAGCTCCACCATGAGGCGAGGTGGATGGAGGAAGCGAGCTGAAAATGATGG
CTGGGAAACATGGGGTGGGTATATGGCTGCCAAGGTCCAGAAATTGGAGGAACAGTTTCGATCAGATGCTGCTATGCAGAAGGATGGGAC
TTCATCTACAATTTTTAGTGGAGTTGCCATCTATGTTAATGGATACACAGGCACTTCCAGGGGCTCATACCCCTTCAGTCACTCAATGAA
GCCTCACCTACATCCACGCCTGTACCACGGCTGCTATGGGGACATCATGACCATGAAGACCTCTGGGGCCACTTGTGATGCAAACAGTGT
GATGAACTGCGGGATCCGTGGTTCTGAAATGTTTGCTGAGATGGATTTGAGGGCCATAAAACCTTACCAGACTCTGATCAAAGAAGTCGG
GCAGAGACATTGCGTGGACCCTGCTGTCATCGCAGCCATCATCTCCAGGGAAAGCCATGGCGGATCTGTCCTGCAAGACGGCTGGGACCA
CAGGGGACTTAAATTTGGCTTGATGCAGCTTGATAAACAAACGTACCACCCTGTCGGTGCCTGGGATAGCAAAGAGCACCTTTCACAGGC
TACTGGGATTCTAACAGAGAGAATTAAGGCAATCCAGAAAAAATTCCCCACGTGGAGTGTTGCTCAGCACCTCAAAGGTAGGCTGTATTC
TGAGTACTTTGTTTAAATGAGCAATGAATGAGACCACTGAAGGCCAGTGTGACCCGAGACTCCCTGGGAGCATTTCCACGGGGTCAGCAG
TGGCCCTGGGAGGAGCTGTCTAGAGGCTGCATTTGCATTCCCTGAACCACTGAGTTACTTTGAGAGGTCCTCCATCCTCAACCTCCATTT

>73574_73574_9_REV1-LYG2_REV1_chr2_100078958_ENST00000258428_LYG2_chr2_99863283_ENST00000409679_length(amino acids)=290AA_BP=1
MVAASVGERGPRRCSAVGLPSPGPPPWSLARALAAAGPGSARPEKAAGPGHGGLGQRGRSSTMRRGGWRKRAENDGWETWGGYMAAKVQK
LEEQFRSDAAMQKDGTSSTIFSGVAIYVNGYTGTSRGSYPFSHSMKPHLHPRLYHGCYGDIMTMKTSGATCDANSVMNCGIRGSEMFAEM
DLRAIKPYQTLIKEVGQRHCVDPAVIAAIISRESHGGSVLQDGWDHRGLKFGLMQLDKQTYHPVGAWDSKEHLSQATGILTERIKAIQKK

--------------------------------------------------------------
>73574_73574_10_REV1-LYG2_REV1_chr2_100078958_ENST00000393445_LYG2_chr2_99863283_ENST00000333017_length(transcript)=1054nt_BP=348nt
GGGAGCGTGGACCGCGGCGCTGCTCAGCGGTGGGGCTGCCTTCCCCCGGCCCTCCTCCCTGGTCCCTGGCGAGGGCACTGGCGGCGGCGG
GGCCGGGGTCCGCAAGGCCGGAGAAGGCCGCCGGGCCCGGGCATGGTGGTCTGGGGCAACGCGGAAGAAGCTCCACCATGAGGCGAGGTG
GATGGAGGAAGCGAGCTGAAAATGATGGCTGGGAAACATGGGGTGGGTATATGGCTGCCAAGGTCCAGAAATTGGAGGAACAGTTTCGAT
CAGATGCTGCTATGCAGAAGGATGGGACTTCATCTACAATTTTTAGTGGAGTTGCCATCTATGTTAATGGATACACAGGCACTTCCAGGG
GCTCATACCCCTTCAGTCACTCAATGAAGCCTCACCTACATCCACGCCTGTACCACGGCTGCTATGGGGACATCATGACCATGAAGACCT
CTGGGGCCACTTGTGATGCAAACAGTGTGATGAACTGCGGGATCCGTGGTTCTGAAATGTTTGCTGAGATGGATTTGAGGGCCATAAAAC
CTTACCAGACTCTGATCAAAGAAGTCGGGCAGAGACATTGCGTGGACCCTGCTGTCATCGCAGCCATCATCTCCAGGGAAAGCCATGGCG
GATCTGTCCTGCAAGACGGCTGGGACCACAGGGGACTTAAATTTGGCTTGATGCAGCTTGATAAACAAACGTACCACCCTGTCGGTGCCT
GGGATAGCAAAGAGCACCTTTCACAGGCTACTGGGATTCTAACAGAGAGAATTAAGGCAATCCAGAAAAAATTCCCCACGTGGAGTGTTG
CTCAGCACCTCAAAGGTGGTCTCTCAGCTTTTAAGTCAGGAATTGAAGCGATTGCCACCCCATCGGACATAGACAATGACTTCGTCAATG
ATATCATTGCTCGAGCTAAGTTCTATAAAAGACAAAGCTTCTAGGCAAAGCTCTGTGGGTGGGCCAGGTTGGCAGAGTGCTCAGATGGCC

>73574_73574_10_REV1-LYG2_REV1_chr2_100078958_ENST00000393445_LYG2_chr2_99863283_ENST00000333017_length(amino acids)=302AA_BP=1
MPSPGPPPWSLARALAAAGPGSARPEKAAGPGHGGLGQRGRSSTMRRGGWRKRAENDGWETWGGYMAAKVQKLEEQFRSDAAMQKDGTSS
TIFSGVAIYVNGYTGTSRGSYPFSHSMKPHLHPRLYHGCYGDIMTMKTSGATCDANSVMNCGIRGSEMFAEMDLRAIKPYQTLIKEVGQR
HCVDPAVIAAIISRESHGGSVLQDGWDHRGLKFGLMQLDKQTYHPVGAWDSKEHLSQATGILTERIKAIQKKFPTWSVAQHLKGGLSAFK

--------------------------------------------------------------
>73574_73574_11_REV1-LYG2_REV1_chr2_100078958_ENST00000393445_LYG2_chr2_99863283_ENST00000409238_length(transcript)=1062nt_BP=348nt
GGGAGCGTGGACCGCGGCGCTGCTCAGCGGTGGGGCTGCCTTCCCCCGGCCCTCCTCCCTGGTCCCTGGCGAGGGCACTGGCGGCGGCGG
GGCCGGGGTCCGCAAGGCCGGAGAAGGCCGCCGGGCCCGGGCATGGTGGTCTGGGGCAACGCGGAAGAAGCTCCACCATGAGGCGAGGTG
GATGGAGGAAGCGAGCTGAAAATGATGGCTGGGAAACATGGGGTGGGTATATGGCTGCCAAGGTCCAGAAATTGGAGGAACAGTTTCGAT
CAGATGCTGCTATGCAGAAGGATGGGACTTCATCTACAATTTTTAGTGGAGTTGCCATCTATGTTAATGGATACACAGGCACTTCCAGGG
GCTCATACCCCTTCAGTCACTCAATGAAGCCTCACCTACATCCACGCCTGTACCACGGCTGCTATGGGGACATCATGACCATGAAGACCT
CTGGGGCCACTTGTGATGCAAACAGTGTGATGAACTGCGGGATCCGTGGTTCTGAAATGTTTGCTGAGATGGATTTGAGGGCCATAAAAC
CTTACCAGACTCTGATCAAAGAAGTCGGGCAGAGACATTGCGTGGACCCTGCTGTCATCGCAGCCATCATCTCCAGGGAAAGCCATGGCG
GATCTGTCCTGCAAGACGGCTGGGACCACAGGGGACTTAAATTTGGCTTGATGCAGCTTGATAAACAAACGTACCACCCTGTCGGTGCCT
GGGATAGCAAAGAGCACCTTTCACAGGCTACTGGGATTCTAACAGAGAGAATTAAGGCAATCCAGAAAAAATTCCCCACGTGGAGTGTTG
CTCAGCACCTCAAAGGTGGTCTCTCAGCTTTTAAGTCAGGAATTGAAGCGATTGCCACCCCATCGGACATAGACAATGACTTCGTCAATG
ATATCATTGCTCGAGCTAAGTTCTATAAAAGACAAAGCTTCTAGGCAAAGCTCTGTGGGTGGGCCAGGTTGGCAGAGTGCTCAGATGGCC

>73574_73574_11_REV1-LYG2_REV1_chr2_100078958_ENST00000393445_LYG2_chr2_99863283_ENST00000409238_length(amino acids)=302AA_BP=1
MPSPGPPPWSLARALAAAGPGSARPEKAAGPGHGGLGQRGRSSTMRRGGWRKRAENDGWETWGGYMAAKVQKLEEQFRSDAAMQKDGTSS
TIFSGVAIYVNGYTGTSRGSYPFSHSMKPHLHPRLYHGCYGDIMTMKTSGATCDANSVMNCGIRGSEMFAEMDLRAIKPYQTLIKEVGQR
HCVDPAVIAAIISRESHGGSVLQDGWDHRGLKFGLMQLDKQTYHPVGAWDSKEHLSQATGILTERIKAIQKKFPTWSVAQHLKGGLSAFK

--------------------------------------------------------------
>73574_73574_12_REV1-LYG2_REV1_chr2_100078958_ENST00000393445_LYG2_chr2_99863283_ENST00000409679_length(transcript)=1038nt_BP=348nt
GGGAGCGTGGACCGCGGCGCTGCTCAGCGGTGGGGCTGCCTTCCCCCGGCCCTCCTCCCTGGTCCCTGGCGAGGGCACTGGCGGCGGCGG
GGCCGGGGTCCGCAAGGCCGGAGAAGGCCGCCGGGCCCGGGCATGGTGGTCTGGGGCAACGCGGAAGAAGCTCCACCATGAGGCGAGGTG
GATGGAGGAAGCGAGCTGAAAATGATGGCTGGGAAACATGGGGTGGGTATATGGCTGCCAAGGTCCAGAAATTGGAGGAACAGTTTCGAT
CAGATGCTGCTATGCAGAAGGATGGGACTTCATCTACAATTTTTAGTGGAGTTGCCATCTATGTTAATGGATACACAGGCACTTCCAGGG
GCTCATACCCCTTCAGTCACTCAATGAAGCCTCACCTACATCCACGCCTGTACCACGGCTGCTATGGGGACATCATGACCATGAAGACCT
CTGGGGCCACTTGTGATGCAAACAGTGTGATGAACTGCGGGATCCGTGGTTCTGAAATGTTTGCTGAGATGGATTTGAGGGCCATAAAAC
CTTACCAGACTCTGATCAAAGAAGTCGGGCAGAGACATTGCGTGGACCCTGCTGTCATCGCAGCCATCATCTCCAGGGAAAGCCATGGCG
GATCTGTCCTGCAAGACGGCTGGGACCACAGGGGACTTAAATTTGGCTTGATGCAGCTTGATAAACAAACGTACCACCCTGTCGGTGCCT
GGGATAGCAAAGAGCACCTTTCACAGGCTACTGGGATTCTAACAGAGAGAATTAAGGCAATCCAGAAAAAATTCCCCACGTGGAGTGTTG
CTCAGCACCTCAAAGGTAGGCTGTATTCTGAGTACTTTGTTTAAATGAGCAATGAATGAGACCACTGAAGGCCAGTGTGACCCGAGACTC
CCTGGGAGCATTTCCACGGGGTCAGCAGTGGCCCTGGGAGGAGCTGTCTAGAGGCTGCATTTGCATTCCCTGAACCACTGAGTTACTTTG

>73574_73574_12_REV1-LYG2_REV1_chr2_100078958_ENST00000393445_LYG2_chr2_99863283_ENST00000409679_length(amino acids)=272AA_BP=1
MPSPGPPPWSLARALAAAGPGSARPEKAAGPGHGGLGQRGRSSTMRRGGWRKRAENDGWETWGGYMAAKVQKLEEQFRSDAAMQKDGTSS
TIFSGVAIYVNGYTGTSRGSYPFSHSMKPHLHPRLYHGCYGDIMTMKTSGATCDANSVMNCGIRGSEMFAEMDLRAIKPYQTLIKEVGQR
HCVDPAVIAAIISRESHGGSVLQDGWDHRGLKFGLMQLDKQTYHPVGAWDSKEHLSQATGILTERIKAIQKKFPTWSVAQHLKGRLYSEY

--------------------------------------------------------------

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Fusion Gene PPI Analysis for REV1-LYG2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneREV1chr2:100078957chr2:99863283ENST00000258428-323352_36260.3333333333333361252.0target DNA
HgeneREV1chr2:100078957chr2:99863283ENST00000258428-323653_65660.3333333333333361252.0target DNA
HgeneREV1chr2:100078957chr2:99863283ENST00000258428-323709_71760.3333333333333361252.0target DNA
HgeneREV1chr2:100078957chr2:99863283ENST00000393445-323352_36260.3333333333333361251.0target DNA
HgeneREV1chr2:100078957chr2:99863283ENST00000393445-323653_65660.3333333333333361251.0target DNA
HgeneREV1chr2:100078957chr2:99863283ENST00000393445-323709_71760.3333333333333361251.0target DNA
HgeneREV1chr2:100078958chr2:99863283ENST00000258428-323352_36260.3333333333333361252.0target DNA
HgeneREV1chr2:100078958chr2:99863283ENST00000258428-323653_65660.3333333333333361252.0target DNA
HgeneREV1chr2:100078958chr2:99863283ENST00000258428-323709_71760.3333333333333361252.0target DNA
HgeneREV1chr2:100078958chr2:99863283ENST00000393445-323352_36260.3333333333333361251.0target DNA
HgeneREV1chr2:100078958chr2:99863283ENST00000393445-323653_65660.3333333333333361251.0target DNA
HgeneREV1chr2:100078958chr2:99863283ENST00000393445-323709_71760.3333333333333361251.0target DNA


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for REV1-LYG2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for REV1-LYG2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource