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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:REV3L-ASCC3 (FusionGDB2 ID:73583)

Fusion Gene Summary for REV3L-ASCC3

check button Fusion gene summary
Fusion gene informationFusion gene name: REV3L-ASCC3
Fusion gene ID: 73583
HgeneTgene
Gene symbol

REV3L

ASCC3

Gene ID

5980

10973

Gene nameREV3 like, DNA directed polymerase zeta catalytic subunitactivating signal cointegrator 1 complex subunit 3
SynonymsPOLZ|REV3ASC1p200|HELIC1|RNAH
Cytomap

6q21

6q16.3

Type of geneprotein-codingprotein-coding
DescriptionDNA polymerase zeta catalytic subunitREV3-like, polymerase (DNA directed), zeta, catalytic subunitRev-3, yeast, homolog-like (polymerase, DNA, zeta)activating signal cointegrator 1 complex subunit 3ASC-1 complex subunit P200RNA helicase familyhelicase, ATP binding 1trip4 complex subunit p200
Modification date2020031320200313
UniProtAcc.

Q8N3C0

Ensembl transtripts involved in fusion geneENST00000358835, ENST00000368802, 
ENST00000368805, ENST00000435970, 
ENST00000462119, 		ENST00000369143, 
ENST00000369162, ENST00000522650, 
Fusion gene scores* DoF score17 X 20 X 10=340014 X 10 X 11=1540
# samples 2618
** MAII scorelog2(26/3400*10)=-3.70895121799661
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/1540*10)=-3.09686153925259
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: REV3L [Title/Abstract] AND ASCC3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointREV3L(111803952)-ASCC3(101253756), # samples:1
Anticipated loss of major functional domain due to fusion event.REV3L-ASCC3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneASCC3

GO:0006307

DNA dealkylation involved in DNA repair

22055184

TgeneASCC3

GO:0032508

DNA duplex unwinding

22055184


check buttonFusion gene breakpoints across REV3L (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ASCC3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4G2REV3Lchr6

111803952

-ASCC3chr6

101253756

-


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Fusion Gene ORF analysis for REV3L-ASCC3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000358835ENST00000369143REV3Lchr6

111803952

-ASCC3chr6

101253756

-
5CDS-intronENST00000368802ENST00000369143REV3Lchr6

111803952

-ASCC3chr6

101253756

-
5CDS-intronENST00000368805ENST00000369143REV3Lchr6

111803952

-ASCC3chr6

101253756

-
5UTR-3CDSENST00000435970ENST00000369162REV3Lchr6

111803952

-ASCC3chr6

101253756

-
5UTR-3CDSENST00000435970ENST00000522650REV3Lchr6

111803952

-ASCC3chr6

101253756

-
5UTR-intronENST00000435970ENST00000369143REV3Lchr6

111803952

-ASCC3chr6

101253756

-
Frame-shiftENST00000358835ENST00000369162REV3Lchr6

111803952

-ASCC3chr6

101253756

-
Frame-shiftENST00000358835ENST00000522650REV3Lchr6

111803952

-ASCC3chr6

101253756

-
Frame-shiftENST00000368805ENST00000369162REV3Lchr6

111803952

-ASCC3chr6

101253756

-
Frame-shiftENST00000368805ENST00000522650REV3Lchr6

111803952

-ASCC3chr6

101253756

-
In-frameENST00000368802ENST00000369162REV3Lchr6

111803952

-ASCC3chr6

101253756

-
In-frameENST00000368802ENST00000522650REV3Lchr6

111803952

-ASCC3chr6

101253756

-
intron-3CDSENST00000462119ENST00000369162REV3Lchr6

111803952

-ASCC3chr6

101253756

-
intron-3CDSENST00000462119ENST00000522650REV3Lchr6

111803952

-ASCC3chr6

101253756

-
intron-intronENST00000462119ENST00000369143REV3Lchr6

111803952

-ASCC3chr6

101253756

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000368802REV3Lchr6111803952-ENST00000369162ASCC3chr6101253756-746246234562691974
ENST00000368802REV3Lchr6111803952-ENST00000522650ASCC3chr6101253756-21444623451856503

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000368802ENST00000369162REV3Lchr6111803952-ASCC3chr6101253756-0.0009361590.9990639
ENST00000368802ENST00000522650REV3Lchr6111803952-ASCC3chr6101253756-0.001442380.9985576

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Fusion Genomic Features for REV3L-ASCC3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for REV3L-ASCC3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:111803952/chr6:101253756)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ASCC3

Q8N3C0

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: 3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions (PubMed:22055184). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347). {ECO:0000269|PubMed:12077347, ECO:0000269|PubMed:22055184}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneASCC3chr6:111803952chr6:101253756ENST000003691430418_790112.0Coiled coilOntology_term=ECO:0000255
TgeneASCC3chr6:111803952chr6:101253756ENST0000036914304328_3560112.0Coiled coilOntology_term=ECO:0000255
TgeneASCC3chr6:111803952chr6:101253756ENST00000369162342328_3562672203.0Coiled coilOntology_term=ECO:0000255
TgeneASCC3chr6:111803952chr6:101253756ENST00000522650313328_356267732.0Coiled coilOntology_term=ECO:0000255
TgeneASCC3chr6:111803952chr6:101253756ENST00000369143041336_15110112.0DomainHelicase ATP-binding 2
TgeneASCC3chr6:111803952chr6:101253756ENST00000369143041544_17390112.0DomainHelicase C-terminal 2
TgeneASCC3chr6:111803952chr6:101253756ENST00000369143041812_21760112.0DomainNote=SEC63 2
TgeneASCC3chr6:111803952chr6:101253756ENST0000036914304486_6690112.0DomainHelicase ATP-binding 1
TgeneASCC3chr6:111803952chr6:101253756ENST0000036914304728_9140112.0DomainHelicase C-terminal 1
TgeneASCC3chr6:111803952chr6:101253756ENST0000036914304978_12870112.0DomainNote=SEC63 1
TgeneASCC3chr6:111803952chr6:101253756ENST000003691623421336_15112672203.0DomainHelicase ATP-binding 2
TgeneASCC3chr6:111803952chr6:101253756ENST000003691623421544_17392672203.0DomainHelicase C-terminal 2
TgeneASCC3chr6:111803952chr6:101253756ENST000003691623421812_21762672203.0DomainNote=SEC63 2
TgeneASCC3chr6:111803952chr6:101253756ENST00000369162342486_6692672203.0DomainHelicase ATP-binding 1
TgeneASCC3chr6:111803952chr6:101253756ENST00000369162342728_9142672203.0DomainHelicase C-terminal 1
TgeneASCC3chr6:111803952chr6:101253756ENST00000369162342978_12872672203.0DomainNote=SEC63 1
TgeneASCC3chr6:111803952chr6:101253756ENST000005226503131336_1511267732.0DomainHelicase ATP-binding 2
TgeneASCC3chr6:111803952chr6:101253756ENST000005226503131544_1739267732.0DomainHelicase C-terminal 2
TgeneASCC3chr6:111803952chr6:101253756ENST000005226503131812_2176267732.0DomainNote=SEC63 2
TgeneASCC3chr6:111803952chr6:101253756ENST00000522650313486_669267732.0DomainHelicase ATP-binding 1
TgeneASCC3chr6:111803952chr6:101253756ENST00000522650313728_914267732.0DomainHelicase C-terminal 1
TgeneASCC3chr6:111803952chr6:101253756ENST00000522650313978_1287267732.0DomainNote=SEC63 1
TgeneASCC3chr6:111803952chr6:101253756ENST00000369143041453_14560112.0MotifNote=DEIH box
TgeneASCC3chr6:111803952chr6:101253756ENST0000036914304611_6140112.0MotifNote=DEVH box
TgeneASCC3chr6:111803952chr6:101253756ENST000003691623421453_14562672203.0MotifNote=DEIH box
TgeneASCC3chr6:111803952chr6:101253756ENST00000369162342611_6142672203.0MotifNote=DEVH box
TgeneASCC3chr6:111803952chr6:101253756ENST000005226503131453_1456267732.0MotifNote=DEIH box
TgeneASCC3chr6:111803952chr6:101253756ENST00000522650313611_614267732.0MotifNote=DEVH box
TgeneASCC3chr6:111803952chr6:101253756ENST00000369143041349_13560112.0Nucleotide bindingATP
TgeneASCC3chr6:111803952chr6:101253756ENST0000036914304499_5060112.0Nucleotide bindingATP
TgeneASCC3chr6:111803952chr6:101253756ENST000003691623421349_13562672203.0Nucleotide bindingATP
TgeneASCC3chr6:111803952chr6:101253756ENST00000369162342499_5062672203.0Nucleotide bindingATP
TgeneASCC3chr6:111803952chr6:101253756ENST000005226503131349_1356267732.0Nucleotide bindingATP
TgeneASCC3chr6:111803952chr6:101253756ENST00000522650313499_506267732.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneREV3Lchr6:111803952chr6:101253756ENST00000358835-2333086_3104463131.0MotifNote=CysB motif
HgeneREV3Lchr6:111803952chr6:101253756ENST00000368802-1323086_3104463131.0MotifNote=CysB motif
HgeneREV3Lchr6:111803952chr6:101253756ENST00000368805-2333086_3104463131.0MotifNote=CysB motif
HgeneREV3Lchr6:111803952chr6:101253756ENST00000435970-2343086_310403053.0MotifNote=CysB motif
HgeneREV3Lchr6:111803952chr6:101253756ENST00000358835-2333042_3057463131.0Zinc fingerNote=CysA-type
HgeneREV3Lchr6:111803952chr6:101253756ENST00000368802-1323042_3057463131.0Zinc fingerNote=CysA-type
HgeneREV3Lchr6:111803952chr6:101253756ENST00000368805-2333042_3057463131.0Zinc fingerNote=CysA-type
HgeneREV3Lchr6:111803952chr6:101253756ENST00000435970-2343042_305703053.0Zinc fingerNote=CysA-type
TgeneASCC3chr6:111803952chr6:101253756ENST0000036916234218_792672203.0Coiled coilOntology_term=ECO:0000255
TgeneASCC3chr6:111803952chr6:101253756ENST0000052265031318_79267732.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for REV3L-ASCC3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>73583_73583_1_REV3L-ASCC3_REV3L_chr6_111803952_ENST00000368802_ASCC3_chr6_101253756_ENST00000369162_length(transcript)=7462nt_BP=462nt
CATCATCATGGCAACAAGAGCTGCAGCCTGGGACCGAGGAGCCCGTGTGATTCCCGGCGGTGGCGGCAGTGGCGGCAGCACCAGCACCGA
CGAAAGCTCGAGGGCTTCTCTCCTGCGGCCCCTTGCCGGGTGCTCCTGAGGAGGCGGCGGCAGCAGCGCCTACACCGCCCCGCCCGCCGC
TCCTCGAGGTGCCTCTGTGTGAGGGGAGGGGGCCGTGCCGAGAAGGGGAGGGGGCGCCGCCGCCGCTGCGGAGGGAGCCGCCGCCGCTGC
TGCTGCCGCTGCCGGGTCGCCAGTGAAGGGAGGCAGTGGCGGCGGCGGCGAACATGTTTTCAGTAAGGATAGTGACTGCAGACTACTACA
TGGCCAGCCCGCTGCAGGGGCTGGATACCTGCCAATCCCCCCTCACCCAGGCCCCTGTCAAGAAGGTGCCGGTGGTGCGAGTCTTCGGAG
CGACCCCGGCAGCTATTTGAACTGCTGGGACCTGAAGGACTTGAACTTATTGAGAAACTCCTCCAGAACAGAATTACAATTGTGGATAGA
TTTCTTAATTCTTCAAATGATCATAGGTTTCAGGCTCTTCAAGACAATTGTAAAAAAATTTTAGGAGAAAATGCTAAACCCAATTATGGT
TGTCAAGTCACTATTCAGTCTGAACAAGAAAAGCAGTTAATGAAACAATATCGACGTGAAGAAAAAAGAATTGCCAGACGAGAAAAAAAG
GCTGGAGAAGATTTAGAAGTTTCAGAAGGACTTATGTGCTTTGATCCTAAGGAATTGCGGATACAAAGAGAACAGGCACTTCTGAATGCT
AGAAGTGTTCCAATTCTGAGCAGGCAGAGAGATGCAGACGTTGAAAAAATACATTATCCCCATGTGTATGATTCCCAGGCTGAAGCCATG
AAAACATCAGCATTTATTGCTGGTGCAAAGATGATTTTGCCAGAAGGAATCCAAAGAGAGAATAACAAGCTTTATGAAGAAGTAAGGATT
CCCTACAGCGAACCAATGCCACTCAGCTTTGAGGAAAAGCCAGTTTATATCCAAGACTTAGATGAGATCGGACAGCTGGCTTTTAAAGGA
ATGAAGAGACTCAATAGAATCCAGTCAATAGTGTTTGAGACTGCCTACAACACCAATGAGAACATGCTGATTTGTGCCCCTACAGGAGCT
GGAAAAACCAACATTGCAATGCTGACAGTCTTGCATGAAATTCGCCAACATTTTCAACAAGGTGTTATCAAAAAGAATGAATTTAAGATT
GTATATGTTGCTCCAATGAAAGCCTTGGCAGCTGAAATGACAGATTACTTCAGCAGACGTCTAGAGCCACTAGGCATCATTGTGAAAGAA
TTGACTGGTGACATGCAGTTGTCCAAAAGTGAAATTTTACGAACTCAGATGCTTGTGACCACACCAGAAAAATGGGATGTAGTGACAAGA
AAGAGTGTTGGGGATGTAGCTCTTTCCCAGATTGTAAGGCTCCTTATTCTTGATGAAGTTCATTTGCTGCATGAAGATAGAGGACCAGTA
TTAGAAAGCATAGTTGCCCGTACTTTACGGCAGGTGGAATCCACACAGAGTATGATAAGGATTCTCGGACTGTCTGCAACTTTACCTAAC
TACCTCGATGTTGCCACATTTTTACATGTTAATCCATACATTGGACTTTTCTTCTTTGATGGCCGTTTTCGACCAGTACCTCTTGGACAG
ACATTTTTGGGGATTAAATGTGCAAATAAGATGCAGCAGTTGAATAACATGGATGAAGTATGTTATGAAAATGTTTTGAAGCAAGTAAAG
GCTGGACACCAGGTGATGGTGTTTGTACATGCTCGAAATGCCACTGTAAGAACAGCTATGTCTCTAATAGAAAGAGCAAAAAATTGTGGC
CATATTCCCTTCTTTTTTCCTACCCAAGGACATGACTATGTACTTGCAGAAAAACAGGTACAAAGGTCGAGAAATAAGCAAGTACGAGAA
TTATTCCCAGATGGTTTTAGTATTCATCATGCAGGAATGCTTCGGCAGGACAGAAATTTAGTTGAAAACTTGTTTTCTAATGGGCATATC
AAAGTCCTAGTGTGTACAGCTACGTTAGCCTGGGGTGTCAATCTTCCCGCCCATGCTGTTATTATTAAGGGAACACAAATATATGCTGCA
AAAAGAGGCTCCTTTGTTGACCTTGGAATTTTAGATGTCATGCAGATATTTGGTCGAGCTGGACGACCACAATTTGACAAATTTGGGGAA
GGAATAATTATAACAACGCATGATAAACTCAGCCATTACCTCACTTTGCTCACTCAACGAAACCCAATTGAGAGTCAGTTTCTGGAAAGC
CTTGCAGATAACCTAAATGCAGAGATTGCTCTGGGAACAGTTACTAATGTGGAAGAAGCAGTGAAGTGGATAAGTTACACTTATCTTTAT
GTACGGATGAGAGCAAATCCATTAGCATATGGCATCAGTCACAAGGCTTATCAGATTGACCCAACATTAAGAAAGCATCGAGAACAGTTG
GTCATTGAAGTTGGACGAAAACTAGACAAAGCTCAGATGATTCGTTTTGAGGAGCGAACTGGATATTTTTCCTCAACTGATTTGGGTAGA
ACTGCCAGCCATTACTATATTAAATACAACACCATTGAGACCTTTAATGAACTCTTTGATGCTCACAAAACAGAAGGTGATATCTTTGCC
ATAGTCTCCAAAGCTGAAGAATTTGATCAAATTAAGGTCAGAGAAGAGGAAATAGAGGAGTTAGATACCTTATTAAGCAATTTTTGTGAA
CTCTCCACTCCTGGAGGTGTAGAGAATAGTTATGGGAAAATAAACATCTTACTTCAAACTTATATCAGCCGAGGAGAAATGGACAGTTTC
TCCCTTATATCAGATTCTGCATATGTTGCACAGAATGCAGCTAGAATTGTCCGTGCTCTTTTTGAAATTGCTCTGAGGAAACGTTGGCCT
ACCATGACCTACAGGCTCCTGAATCTTAGTAAAGTCATTGACAAGAGGCTTTGGGGTTGGGCTAGCCCTTTGAGACAATTTTCAATCCTA
CCACCACACATCCTAACAAGATTAGAAGAAAAAAAGCTTACTGTGGATAAGCTGAAAGACATGAGGAAAGATGAAATAGGTCACATTTTA
CATCATGTGAATATTGGACTGAAGGTCAAACAATGTGTTCATCAGATTCCTTCTGTTATGATGGAAGCATCCATTCAGCCTATCACAAGG
ACTGTCCTCCGAGTGACACTCAGCATCTATGCTGATTTCACTTGGAATGATCAGGTACATGGGACAGTAGGAGAACCTTGGTGGATTTGG
GTAGAAGATCCTACAAATGATCATATTTATCATTCAGAGTATTTTCTAGCTCTAAAAAAACAAGTCATTAGTAAAGAAGCCCAACTACTG
GTATTTACAATCCCTATTTTTGAGCCTTTGCCTTCCCAATACTACATCCGAGCAGTGTCTGATAGATGGTTGGGTGCTGAGGCAGTATGT
ATTATCAACTTTCAACATCTAATTCTACCAGAGAGACATCCTCCTCATACAGAATTACTGGATCTTCAGCCTTTACCAATCACAGCTTTG
GGATGTAAAGCATATGAAGCCCTGTACAACTTCAGCCACTTTAACCCTGTACAGACACAAATATTTCATACATTGTATCACACGGATTGT
AATGTCCTACTTGGAGCACCTACTGGATCGGGAAAGACTGTTGCAGCTGAATTAGCCATTTTCAGAGTCTTCAACAAATACCCTACTTCA
AAGGCGGTATATATTGCACCCCTAAAAGCCCTAGTACGTGAAAGAATGGATGATTGGAAAGTTAGAATAGAAGAAAAACTTGGTAAAAAA
GTTATTGAACTAACAGGGGATGTGACTCCTGATATGAAATCCATTGCCAAGGCTGACCTTATCGTCACTACGCCAGAGAAGTGGGATGGA
GTCAGCAGAAGCTGGCAAAATAGGAACTATGTTCAGCAAGTCACTATTCTCATCATAGATGAGATCCATCTGCTTGGGGAGGAAAGAGGC
CCTGTTCTAGAGGTCATTGTATCTCGAACAAATTTTATCTCATCACACACAGAAAAGCCTGTTAGAATAGTTGGACTATCTACTGCATTA
GCTAATGCCAGAGACCTTGCTGATTGGCTCAATATTAAGCAGATGGGCTTGTTTAACTTCCGACCATCAGTACGCCCAGTTCCACTGGAA
GTTCACATTCAAGGCTTTCCAGGTCAACATTACTGTCCTCGTATGGCTAGTATGAACAAGCCTGCATTTCAGGCAATTAGAAGCCATTCT
CCAGCCAAACCTGTTTTGATATTTGTCTCATCAAGACGTCAAACTCGTCTTACTGCTTTGGAATTGATCGCCTTCCTGGCTACTGAAGAA
GATCCAAAGCAGTGGTTAAACATGGATGAAAGAGAGATGGAGAACATCATTGCAACAGTAAGAGATTCCAACCTCAAGCTGACCCTTGCT
TTCGGGATAGGAATGCATCATGCTGGACTACATGAGAGGGACCGAAAAACAGTAGAGGAACTATTTGTAAACTGTAAAGTTCAGGTTCTT
ATTGCTACAAGCACATTAGCCTGGGGTGTAAACTTTCCAGCTCATTTAGTAATTATTAAGGGAACAGAATACTATGATGGAAAAACAAGA
CGTTATGTGGATTTTCCCATTACAGATGTCCTCCAGATGATGGGGCGTGCTGGGAGGCCGCAGTTCGATGACCAAGGCAAAGCTGTAATT
CTAGTTCATGACATAAAGAAAGACTTTTATAAAAAATTTCTTTATGAACCTTTCCCAGTAGAATCAAGTTTATTAGGAGTGCTCTCTGAC
CACTTAAATGCAGAGATTGCTGGTGGTACAATTACATCTAAGCAAGATGCATTGGATTATATCACCTGGACTTACTTTTTCCGACGTCTT
ATCATGAATCCCAGCTATTACAATTTGGGTGATGTGAGCCATGATTCTGTGAACAAGTTTCTGTCCCATCTGATTGAGAAGTCCCTGATT
GAATTGGAACTTTCCTACTGTATTGAAATTGGAGAGGATAATCGCAGCATTGAACCTCTAACTTATGGCCGAATTGCCTCCTATTACTAT
TTGAAGCATCAAACAGTTAAAATGTTCAAGGACCGCTTGAAGCCTGAATGCAGTACTGAAGAACTGCTTTCAATTCTAAGTGATGCAGAA
GAATATACAGATTTGCCAGTGAGACACAATGAAGATCATATGAATAGTGAACTGGCAAAATGTCTTCCCATTGAATCAAATCCTCATTCA
TTTGACAGCCCTCACACCAAAGCACATCTCCTGCTACAGGCACATCTCAGCCGAGCCATGCTACCCTGCCCAGATTATGACACTGATACC
AAAACAGTCTTGGACCAAGCTCTCAGAGTATGTCAGGCAATGCTGGACGTGGCTGCAAACCAGGGCTGGCTGGTGACTGTCCTGAATATC
ACCAACCTGATTCAGATGGTGATCCAGGGTCGGTGGTTAAAGGACTCTTCTCTTCTTACACTACCAAACATAGAAAACCATCATCTTCAC
CTTTTCAAGAAATGGAAGCCGATTATGAAGGGCCCACATGCTAGGGGTCGGACCTCCATCGAGTCCCTTCCTGAACTGATCCATGCCTGT
GGAGGGAAAGACCATGTATTTAGCTCCATGGTAGAAAGTGAGCTACATGCTGCAAAAACGAAACAGGCATGGAATTTCTTATCTCACTTG
CCAGTGATAAATGTTGGCATAAGTGTTAAAGGCTCGTGGGATGACTTAGTTGAAGGACATAATGAACTCTCTGTCTCAACTCTGACTGCA
GACAAACGAGATGACAACAAATGGATCAAATTGCATGCTGACCAAGAGTATGTGCTTCAAGTGAGCTTGCAGAGAGTCCACTTTGGGTTC
CACAAGGGAAAGCCAGAGAGCTGTGCAGTTACTCCTCGATTTCCCAAATCAAAAGACGAAGGATGGTTTTTGATATTAGGAGAAGTGGAT
AAGAGAGAACTTATTGCTTTGAAAAGAGTAGGATATATTCGAAATCATCATGTTGCTTCCCTTTCTTTTTATACCCCTGAAATACCTGGA
AGGTATATCTACACATTATATTTCATGAGTGACTGCTACCTTGGCCTGGACCAGCAGTATGACATCTATCTCAACGTTACACAAGCGAGT
CTTTCTGCACAGGTCAACACCAAGGTCTCTGATTCCCTGACTGACCTGGCATTAAAGTAACTTGACCTGAACAATCCATTTGAAAGGAGT
GGCTAAGAATTCTCTCTGTTCAGTCATCTAGACAAATCGAATTACTTGATGTTTGCCTTGAAAGAATCAACTTCTAACCTCAACCATCCA
GGAAATTGACAGTGGCTGCAGTATTGACTCCAGTGACATAAAGTTAACCACAGTGGCCTTTTAACAAATGTTGCCTTTTATAATGTTATC
TTTATGAGTTTCTTGATATGTAAGATGAAAAAGCATTTAGAATAATCTTTTAATTTGTGTATATTTGGGATGATATTTAGGAGCTATCAA
TCAAATTTTACATCTCACAATGTACTGTTTACATGGATATTGGCTGCTTTTTTTAAGGAAAACCACATTGAGATGTGACAAGTGTTAGGA
CTTGTCACAGATTTCTAACTCTGCCGCATAAACTATAAATCTGTAAGGTGGTACACAGCGTGTCTTGTTAGCAAAATTTATACTTTGATA
TGATCACATGTAGAAGTAGCTTCAAGAATTTCTTGTAGTCATAAATGTTTAATAATATATGATGTAAAATTATATTATGGAGCCTAATGA
TGATAACAAAGAAAACAATATACTGATCTTAGAAAATGTAGACATGGTTAACTGGGAAATAAAATATAGAGTGGCACTTCAAGACAAGCT
GACTCAATGTTTTCTTCTGCTTCCTTTAAATAATATCCCCTTACTCATCTGTTCTTCTTTTCTTTCCCTTCTACTTCAAGGCTTTATTTC
TATTATCTTTCTGACATATTTATTTACAGAAGTAGAGAAGTATAATCTAATTCATGTTGTAGCACTTACAGATCATATAGTACAATTATT
TGTCTTTATGCTCTCCAGGAAAAATCTGAGACAGAAAATTTTTCACCCCTATGGATAGGTTTTCACCTGTAATAAAGAAAATTTCTCTAT
GTCCAAACAAATTCCTTCTTGAAAAATACTTTTTCAAACTAAAAACTTGTTAAAATTCAATGTTCATATAATATGCATTCTAGTGGAATG
AAATTCTACCTTTGTGAAATAATTTCAGTTTTCTTAGCCCTAAAATGAATTATTTTAAAACATTTTCCAATGTCATTGTTACAAATACTA

>73583_73583_1_REV3L-ASCC3_REV3L_chr6_111803952_ENST00000368802_ASCC3_chr6_101253756_ENST00000369162_length(amino acids)=1974AA_BP=39
MQTTTWPARCRGWIPANPPSPRPLSRRCRWCESSERPRQLFELLGPEGLELIEKLLQNRITIVDRFLNSSNDHRFQALQDNCKKILGENA
KPNYGCQVTIQSEQEKQLMKQYRREEKRIARREKKAGEDLEVSEGLMCFDPKELRIQREQALLNARSVPILSRQRDADVEKIHYPHVYDS
QAEAMKTSAFIAGAKMILPEGIQRENNKLYEEVRIPYSEPMPLSFEEKPVYIQDLDEIGQLAFKGMKRLNRIQSIVFETAYNTNENMLIC
APTGAGKTNIAMLTVLHEIRQHFQQGVIKKNEFKIVYVAPMKALAAEMTDYFSRRLEPLGIIVKELTGDMQLSKSEILRTQMLVTTPEKW
DVVTRKSVGDVALSQIVRLLILDEVHLLHEDRGPVLESIVARTLRQVESTQSMIRILGLSATLPNYLDVATFLHVNPYIGLFFFDGRFRP
VPLGQTFLGIKCANKMQQLNNMDEVCYENVLKQVKAGHQVMVFVHARNATVRTAMSLIERAKNCGHIPFFFPTQGHDYVLAEKQVQRSRN
KQVRELFPDGFSIHHAGMLRQDRNLVENLFSNGHIKVLVCTATLAWGVNLPAHAVIIKGTQIYAAKRGSFVDLGILDVMQIFGRAGRPQF
DKFGEGIIITTHDKLSHYLTLLTQRNPIESQFLESLADNLNAEIALGTVTNVEEAVKWISYTYLYVRMRANPLAYGISHKAYQIDPTLRK
HREQLVIEVGRKLDKAQMIRFEERTGYFSSTDLGRTASHYYIKYNTIETFNELFDAHKTEGDIFAIVSKAEEFDQIKVREEEIEELDTLL
SNFCELSTPGGVENSYGKINILLQTYISRGEMDSFSLISDSAYVAQNAARIVRALFEIALRKRWPTMTYRLLNLSKVIDKRLWGWASPLR
QFSILPPHILTRLEEKKLTVDKLKDMRKDEIGHILHHVNIGLKVKQCVHQIPSVMMEASIQPITRTVLRVTLSIYADFTWNDQVHGTVGE
PWWIWVEDPTNDHIYHSEYFLALKKQVISKEAQLLVFTIPIFEPLPSQYYIRAVSDRWLGAEAVCIINFQHLILPERHPPHTELLDLQPL
PITALGCKAYEALYNFSHFNPVQTQIFHTLYHTDCNVLLGAPTGSGKTVAAELAIFRVFNKYPTSKAVYIAPLKALVRERMDDWKVRIEE
KLGKKVIELTGDVTPDMKSIAKADLIVTTPEKWDGVSRSWQNRNYVQQVTILIIDEIHLLGEERGPVLEVIVSRTNFISSHTEKPVRIVG
LSTALANARDLADWLNIKQMGLFNFRPSVRPVPLEVHIQGFPGQHYCPRMASMNKPAFQAIRSHSPAKPVLIFVSSRRQTRLTALELIAF
LATEEDPKQWLNMDEREMENIIATVRDSNLKLTLAFGIGMHHAGLHERDRKTVEELFVNCKVQVLIATSTLAWGVNFPAHLVIIKGTEYY
DGKTRRYVDFPITDVLQMMGRAGRPQFDDQGKAVILVHDIKKDFYKKFLYEPFPVESSLLGVLSDHLNAEIAGGTITSKQDALDYITWTY
FFRRLIMNPSYYNLGDVSHDSVNKFLSHLIEKSLIELELSYCIEIGEDNRSIEPLTYGRIASYYYLKHQTVKMFKDRLKPECSTEELLSI
LSDAEEYTDLPVRHNEDHMNSELAKCLPIESNPHSFDSPHTKAHLLLQAHLSRAMLPCPDYDTDTKTVLDQALRVCQAMLDVAANQGWLV
TVLNITNLIQMVIQGRWLKDSSLLTLPNIENHHLHLFKKWKPIMKGPHARGRTSIESLPELIHACGGKDHVFSSMVESELHAAKTKQAWN
FLSHLPVINVGISVKGSWDDLVEGHNELSVSTLTADKRDDNKWIKLHADQEYVLQVSLQRVHFGFHKGKPESCAVTPRFPKSKDEGWFLI

--------------------------------------------------------------
>73583_73583_2_REV3L-ASCC3_REV3L_chr6_111803952_ENST00000368802_ASCC3_chr6_101253756_ENST00000522650_length(transcript)=2144nt_BP=462nt
CATCATCATGGCAACAAGAGCTGCAGCCTGGGACCGAGGAGCCCGTGTGATTCCCGGCGGTGGCGGCAGTGGCGGCAGCACCAGCACCGA
CGAAAGCTCGAGGGCTTCTCTCCTGCGGCCCCTTGCCGGGTGCTCCTGAGGAGGCGGCGGCAGCAGCGCCTACACCGCCCCGCCCGCCGC
TCCTCGAGGTGCCTCTGTGTGAGGGGAGGGGGCCGTGCCGAGAAGGGGAGGGGGCGCCGCCGCCGCTGCGGAGGGAGCCGCCGCCGCTGC
TGCTGCCGCTGCCGGGTCGCCAGTGAAGGGAGGCAGTGGCGGCGGCGGCGAACATGTTTTCAGTAAGGATAGTGACTGCAGACTACTACA
TGGCCAGCCCGCTGCAGGGGCTGGATACCTGCCAATCCCCCCTCACCCAGGCCCCTGTCAAGAAGGTGCCGGTGGTGCGAGTCTTCGGAG
CGACCCCGGCAGCTATTTGAACTGCTGGGACCTGAAGGACTTGAACTTATTGAGAAACTCCTCCAGAACAGAATTACAATTGTGGATAGA
TTTCTTAATTCTTCAAATGATCATAGGTTTCAGGCTCTTCAAGACAATTGTAAAAAAATTTTAGGAGAAAATGCTAAACCCAATTATGGT
TGTCAAGTCACTATTCAGTCTGAACAAGAAAAGCAGTTAATGAAACAATATCGACGTGAAGAAAAAAGAATTGCCAGACGAGAAAAAAAG
GCTGGAGAAGATTTAGAAGTTTCAGAAGGACTTATGTGCTTTGATCCTAAGGAATTGCGGATACAAAGAGAACAGGCACTTCTGAATGCT
AGAAGTGTTCCAATTCTGAGCAGGCAGAGAGATGCAGACGTTGAAAAAATACATTATCCCCATGTGTATGATTCCCAGGCTGAAGCCATG
AAAACATCAGCATTTATTGCTGGTGCAAAGATGATTTTGCCAGAAGGAATCCAAAGAGAGAATAACAAGCTTTATGAAGAAGTAAGGATT
CCCTACAGCGAACCAATGCCACTCAGCTTTGAGGAAAAGCCAGTTTATATCCAAGACTTAGATGAGATCGGACAGCTGGCTTTTAAAGGA
ATGAAGAGACTCAATAGAATCCAGTCAATAGTGTTTGAGACTGCCTACAACACCAATGAGAACATGCTGATTTGTGCCCCTACAGGAGCT
GGAAAAACCAACATTGCAATGCTGACAGTCTTGCATGAAATTCGCCAACATTTTCAACAAGGTGTTATCAAAAAGAATGAATTTAAGATT
GTATATGTTGCTCCAATGAAAGCCTTGGCAGCTGAAATGACAGATTACTTCAGCAGACGTCTAGAGCCACTAGGCATCATTGTGAAAGAA
TTGACTGGTGACATGCAGTTGTCCAAAAGTGAAATTTTACGAACTCAGATGCTTGTGACCACACCAGAAAAATGGGATGTAGTGACAAGA
AAGAGTGTTGGGGATGTAGCTCTTTCCCAGATTGTAAGGCTCCTTATTCTTGATGAAGTTCATTTGCTGCATGAAGATAGAGGACCAGTA
TTAGAAAGCATAGTTGCCCGTACTTTACGGCAGGTGGAATCCACACAGAGTATGATAAGGATTCTCGGACTGTCTGCAACTTTACCTAAC
TACCTCGATGTTGCCACATTTTTACATGTTAATCCATACATTGGACTTTTCTTCTTTGATGGCCGTTTTCGACCAGTACCTCTTGGACAG
ACATTTTTGGGGATTAAATGTGCAAATAAGATGCAGCAGTTGAATAACATGGATGAAGTATGTTATGAAAATGTTTTGAAGCAAGTAAAG
GCTGGACACCAGGTACACTTATTTTATCTGCTTTTACACTTATTTATCTGCTTTTAGAGAGTGCTTAATGATAAAAATTATTAATATTTA
CGCTCTTCAGAAGAAAATTTTTCTTTAATTCTGAGGCAATGACTCAGAGGTTCTAATTCTTAATAACTGCTTTAGCCCAATGGGTAAGTC
ATAAAAATATTCATAGATATTATCATCCCAGTATTGATAGGTCGTGCTATTTTGTTTGCCATTTTTAATTTTAAATATTATATTCTTACT

>73583_73583_2_REV3L-ASCC3_REV3L_chr6_111803952_ENST00000368802_ASCC3_chr6_101253756_ENST00000522650_length(amino acids)=503AA_BP=39
MQTTTWPARCRGWIPANPPSPRPLSRRCRWCESSERPRQLFELLGPEGLELIEKLLQNRITIVDRFLNSSNDHRFQALQDNCKKILGENA
KPNYGCQVTIQSEQEKQLMKQYRREEKRIARREKKAGEDLEVSEGLMCFDPKELRIQREQALLNARSVPILSRQRDADVEKIHYPHVYDS
QAEAMKTSAFIAGAKMILPEGIQRENNKLYEEVRIPYSEPMPLSFEEKPVYIQDLDEIGQLAFKGMKRLNRIQSIVFETAYNTNENMLIC
APTGAGKTNIAMLTVLHEIRQHFQQGVIKKNEFKIVYVAPMKALAAEMTDYFSRRLEPLGIIVKELTGDMQLSKSEILRTQMLVTTPEKW
DVVTRKSVGDVALSQIVRLLILDEVHLLHEDRGPVLESIVARTLRQVESTQSMIRILGLSATLPNYLDVATFLHVNPYIGLFFFDGRFRP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for REV3L-ASCC3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for REV3L-ASCC3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for REV3L-ASCC3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource