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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:REV3L-C4B (FusionGDB2 ID:73584)

Fusion Gene Summary for REV3L-C4B

check button Fusion gene summary
Fusion gene informationFusion gene name: REV3L-C4B
Fusion gene ID: 73584
HgeneTgene
Gene symbol

REV3L

C4B

Gene ID

5980

721

Gene nameREV3 like, DNA directed polymerase zeta catalytic subunitcomplement C4B (Chido blood group)
SynonymsPOLZ|REV3C4B1|C4B12|C4B2|C4B3|C4B5|C4BD|C4B_2|C4F|CH|CO4|CPAMD3
Cytomap

6q21

6p21.33

Type of geneprotein-codingprotein-coding
DescriptionDNA polymerase zeta catalytic subunitREV3-like, polymerase (DNA directed), zeta, catalytic subunitRev-3, yeast, homolog-like (polymerase, DNA, zeta)complement C4-BC3 and PZP-like alpha-2-macroglobulin domain-containing protein 3Chido form of C4basic complement C4complement C4B1acomplement component 4B (Chido blood group)
Modification date2020031320200313
UniProtAcc.

P04003

Ensembl transtripts involved in fusion geneENST00000358835, ENST00000368802, 
ENST00000368805, ENST00000435970, 
ENST00000462119, 		ENST00000375177, 
ENST00000411583, ENST00000445788, 
ENST00000449788, ENST00000485543, 
ENST00000487226, ENST00000488817, 
ENST00000494210, ENST00000546399, 
ENST00000548301, ENST00000548530, 
ENST00000550398, ENST00000425700, 
ENST00000435363, 
Fusion gene scores* DoF score17 X 20 X 10=34001 X 1 X 1=1
# samples 261
** MAII scorelog2(26/3400*10)=-3.70895121799661
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: REV3L [Title/Abstract] AND C4B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointREV3L(111726673)-C4B(32002291), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneC4B

GO:0032490

detection of molecule of bacterial origin

22333221


check buttonFusion gene breakpoints across REV3L (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across C4B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-3B-A9HZ-01AREV3Lchr6

111726673

-C4Bchr6

32002291

+


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Fusion Gene ORF analysis for REV3L-C4B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000358835ENST00000375177REV3Lchr6

111726673

-C4Bchr6

32002291

+
5CDS-intronENST00000358835ENST00000411583REV3Lchr6

111726673

-C4Bchr6

32002291

+
5CDS-intronENST00000358835ENST00000445788REV3Lchr6

111726673

-C4Bchr6

32002291

+
5CDS-intronENST00000358835ENST00000449788REV3Lchr6

111726673

-C4Bchr6

32002291

+
5CDS-intronENST00000358835ENST00000485543REV3Lchr6

111726673

-C4Bchr6

32002291

+
5CDS-intronENST00000358835ENST00000487226REV3Lchr6

111726673

-C4Bchr6

32002291

+
5CDS-intronENST00000358835ENST00000488817REV3Lchr6

111726673

-C4Bchr6

32002291

+
5CDS-intronENST00000358835ENST00000494210REV3Lchr6

111726673

-C4Bchr6

32002291

+
5CDS-intronENST00000358835ENST00000546399REV3Lchr6

111726673

-C4Bchr6

32002291

+
5CDS-intronENST00000358835ENST00000548301REV3Lchr6

111726673

-C4Bchr6

32002291

+
5CDS-intronENST00000358835ENST00000548530REV3Lchr6

111726673

-C4Bchr6

32002291

+
5CDS-intronENST00000358835ENST00000550398REV3Lchr6

111726673

-C4Bchr6

32002291

+
5CDS-intronENST00000368802ENST00000375177REV3Lchr6

111726673

-C4Bchr6

32002291

+
5CDS-intronENST00000368802ENST00000411583REV3Lchr6

111726673

-C4Bchr6

32002291

+
5CDS-intronENST00000368802ENST00000445788REV3Lchr6

111726673

-C4Bchr6

32002291

+
5CDS-intronENST00000368802ENST00000449788REV3Lchr6

111726673

-C4Bchr6

32002291

+
5CDS-intronENST00000368802ENST00000485543REV3Lchr6

111726673

-C4Bchr6

32002291

+
5CDS-intronENST00000368802ENST00000487226REV3Lchr6

111726673

-C4Bchr6

32002291

+
5CDS-intronENST00000368802ENST00000488817REV3Lchr6

111726673

-C4Bchr6

32002291

+
5CDS-intronENST00000368802ENST00000494210REV3Lchr6

111726673

-C4Bchr6

32002291

+
5CDS-intronENST00000368802ENST00000546399REV3Lchr6

111726673

-C4Bchr6

32002291

+
5CDS-intronENST00000368802ENST00000548301REV3Lchr6

111726673

-C4Bchr6

32002291

+
5CDS-intronENST00000368802ENST00000548530REV3Lchr6

111726673

-C4Bchr6

32002291

+
5CDS-intronENST00000368802ENST00000550398REV3Lchr6

111726673

-C4Bchr6

32002291

+
5CDS-intronENST00000368805ENST00000375177REV3Lchr6

111726673

-C4Bchr6

32002291

+
5CDS-intronENST00000368805ENST00000411583REV3Lchr6

111726673

-C4Bchr6

32002291

+
5CDS-intronENST00000368805ENST00000445788REV3Lchr6

111726673

-C4Bchr6

32002291

+
5CDS-intronENST00000368805ENST00000449788REV3Lchr6

111726673

-C4Bchr6

32002291

+
5CDS-intronENST00000368805ENST00000485543REV3Lchr6

111726673

-C4Bchr6

32002291

+
5CDS-intronENST00000368805ENST00000487226REV3Lchr6

111726673

-C4Bchr6

32002291

+
5CDS-intronENST00000368805ENST00000488817REV3Lchr6

111726673

-C4Bchr6

32002291

+
5CDS-intronENST00000368805ENST00000494210REV3Lchr6

111726673

-C4Bchr6

32002291

+
5CDS-intronENST00000368805ENST00000546399REV3Lchr6

111726673

-C4Bchr6

32002291

+
5CDS-intronENST00000368805ENST00000548301REV3Lchr6

111726673

-C4Bchr6

32002291

+
5CDS-intronENST00000368805ENST00000548530REV3Lchr6

111726673

-C4Bchr6

32002291

+
5CDS-intronENST00000368805ENST00000550398REV3Lchr6

111726673

-C4Bchr6

32002291

+
5CDS-intronENST00000435970ENST00000375177REV3Lchr6

111726673

-C4Bchr6

32002291

+
5CDS-intronENST00000435970ENST00000411583REV3Lchr6

111726673

-C4Bchr6

32002291

+
5CDS-intronENST00000435970ENST00000445788REV3Lchr6

111726673

-C4Bchr6

32002291

+
5CDS-intronENST00000435970ENST00000449788REV3Lchr6

111726673

-C4Bchr6

32002291

+
5CDS-intronENST00000435970ENST00000485543REV3Lchr6

111726673

-C4Bchr6

32002291

+
5CDS-intronENST00000435970ENST00000487226REV3Lchr6

111726673

-C4Bchr6

32002291

+
5CDS-intronENST00000435970ENST00000488817REV3Lchr6

111726673

-C4Bchr6

32002291

+
5CDS-intronENST00000435970ENST00000494210REV3Lchr6

111726673

-C4Bchr6

32002291

+
5CDS-intronENST00000435970ENST00000546399REV3Lchr6

111726673

-C4Bchr6

32002291

+
5CDS-intronENST00000435970ENST00000548301REV3Lchr6

111726673

-C4Bchr6

32002291

+
5CDS-intronENST00000435970ENST00000548530REV3Lchr6

111726673

-C4Bchr6

32002291

+
5CDS-intronENST00000435970ENST00000550398REV3Lchr6

111726673

-C4Bchr6

32002291

+
Frame-shiftENST00000435970ENST00000425700REV3Lchr6

111726673

-C4Bchr6

32002291

+
Frame-shiftENST00000435970ENST00000435363REV3Lchr6

111726673

-C4Bchr6

32002291

+
In-frameENST00000358835ENST00000425700REV3Lchr6

111726673

-C4Bchr6

32002291

+
In-frameENST00000358835ENST00000435363REV3Lchr6

111726673

-C4Bchr6

32002291

+
In-frameENST00000368802ENST00000425700REV3Lchr6

111726673

-C4Bchr6

32002291

+
In-frameENST00000368802ENST00000435363REV3Lchr6

111726673

-C4Bchr6

32002291

+
In-frameENST00000368805ENST00000425700REV3Lchr6

111726673

-C4Bchr6

32002291

+
In-frameENST00000368805ENST00000435363REV3Lchr6

111726673

-C4Bchr6

32002291

+
intron-3CDSENST00000462119ENST00000425700REV3Lchr6

111726673

-C4Bchr6

32002291

+
intron-3CDSENST00000462119ENST00000435363REV3Lchr6

111726673

-C4Bchr6

32002291

+
intron-intronENST00000462119ENST00000375177REV3Lchr6

111726673

-C4Bchr6

32002291

+
intron-intronENST00000462119ENST00000411583REV3Lchr6

111726673

-C4Bchr6

32002291

+
intron-intronENST00000462119ENST00000445788REV3Lchr6

111726673

-C4Bchr6

32002291

+
intron-intronENST00000462119ENST00000449788REV3Lchr6

111726673

-C4Bchr6

32002291

+
intron-intronENST00000462119ENST00000485543REV3Lchr6

111726673

-C4Bchr6

32002291

+
intron-intronENST00000462119ENST00000487226REV3Lchr6

111726673

-C4Bchr6

32002291

+
intron-intronENST00000462119ENST00000488817REV3Lchr6

111726673

-C4Bchr6

32002291

+
intron-intronENST00000462119ENST00000494210REV3Lchr6

111726673

-C4Bchr6

32002291

+
intron-intronENST00000462119ENST00000546399REV3Lchr6

111726673

-C4Bchr6

32002291

+
intron-intronENST00000462119ENST00000548301REV3Lchr6

111726673

-C4Bchr6

32002291

+
intron-intronENST00000462119ENST00000548530REV3Lchr6

111726673

-C4Bchr6

32002291

+
intron-intronENST00000462119ENST00000550398REV3Lchr6

111726673

-C4Bchr6

32002291

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000368802REV3Lchr6111726673-ENST00000435363C4Bchr632002291+13888883231246307
ENST00000368802REV3Lchr6111726673-ENST00000425700C4Bchr632002291+13708883231246307
ENST00000368805REV3Lchr6111726673-ENST00000435363C4Bchr632002291+1148648831006307
ENST00000368805REV3Lchr6111726673-ENST00000425700C4Bchr632002291+1130648831006307
ENST00000358835REV3Lchr6111726673-ENST00000435363C4Bchr632002291+152010204551378307
ENST00000358835REV3Lchr6111726673-ENST00000425700C4Bchr632002291+150210204551378307

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000368802ENST00000435363REV3Lchr6111726673-C4Bchr632002291+0.011146680.98885334
ENST00000368802ENST00000425700REV3Lchr6111726673-C4Bchr632002291+0.0107457260.98925424
ENST00000368805ENST00000435363REV3Lchr6111726673-C4Bchr632002291+0.0076411430.99235886
ENST00000368805ENST00000425700REV3Lchr6111726673-C4Bchr632002291+0.0074380270.992562
ENST00000358835ENST00000435363REV3Lchr6111726673-C4Bchr632002291+0.0113563330.9886437
ENST00000358835ENST00000425700REV3Lchr6111726673-C4Bchr632002291+0.0110056340.9889944

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Fusion Genomic Features for REV3L-C4B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
REV3Lchr6111726672-C4Bchr632002290+7.26E-080.9999999
REV3Lchr6111726672-C4Bchr632002290+7.26E-080.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for REV3L-C4B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:111726673/chr6:32002291)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.C4B

P04003

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneC4Bchr6:111726673chr6:32002291ENST000003751770411595_174201745.0DomainNTR
TgeneC4Bchr6:111726673chr6:32002291ENST00000375177041702_73601745.0DomainAnaphylatoxin-like
TgeneC4Bchr6:111726673chr6:32002291ENST000004115830411595_174201745.0DomainNTR
TgeneC4Bchr6:111726673chr6:32002291ENST00000411583041702_73601745.0DomainAnaphylatoxin-like
TgeneC4Bchr6:111726673chr6:32002291ENST000004497880411595_174201745.0DomainNTR
TgeneC4Bchr6:111726673chr6:32002291ENST00000449788041702_73601745.0DomainAnaphylatoxin-like

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneREV3Lchr6:111726673chr6:32002291ENST00000358835-5333086_31041883131.0MotifNote=CysB motif
HgeneREV3Lchr6:111726673chr6:32002291ENST00000368802-4323086_31041883131.0MotifNote=CysB motif
HgeneREV3Lchr6:111726673chr6:32002291ENST00000368805-5333086_31041883131.0MotifNote=CysB motif
HgeneREV3Lchr6:111726673chr6:32002291ENST00000435970-6343086_31041103053.0MotifNote=CysB motif
HgeneREV3Lchr6:111726673chr6:32002291ENST00000358835-5333042_30571883131.0Zinc fingerNote=CysA-type
HgeneREV3Lchr6:111726673chr6:32002291ENST00000368802-4323042_30571883131.0Zinc fingerNote=CysA-type
HgeneREV3Lchr6:111726673chr6:32002291ENST00000368805-5333042_30571883131.0Zinc fingerNote=CysA-type
HgeneREV3Lchr6:111726673chr6:32002291ENST00000435970-6343042_30571103053.0Zinc fingerNote=CysA-type
TgeneC4Bchr6:111726673chr6:32002291ENST0000043536337411595_174216251745.0DomainNTR
TgeneC4Bchr6:111726673chr6:32002291ENST000004353633741702_73616251745.0DomainAnaphylatoxin-like


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Fusion Gene Sequence for REV3L-C4B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>73584_73584_1_REV3L-C4B_REV3L_chr6_111726673_ENST00000358835_C4B_chr6_32002291_ENST00000425700_length(transcript)=1502nt_BP=1020nt
CGAGATCTGCGCCTCGCCTCCCTCCTCACGCGGGCGGATTTTCTTACCTTGTGAAAAACCGTCTCAGCGGCTGCCCCCGCCTCCTCTGCT
GGATGTGAAATGGCGGTCGGCGAGTGGTTGCGTCCGTGACATCATCATCATGGCAACAAGAGCTGCAGCCTGGGACCGAGGAGCCCGTGT
GATTCCCGGCGGTGGCGGCAGTGGCGGCAGCACCAGCACCGACGAAAGCTCGAGGGCTTCTCTCCTGCGGCCCCTTGCCGGGTGCTCCTG
AGGAGGCGGCGGCAGCAGCGCCTACACCGCCCCGCCCGCCGCTCCTCGAGGTGCCTCTGTGTGAGGGGAGGGGGCCGTGCCGAGAAGGGG
AGGGGGCGCCGCCGCCGCTGCGGAGGGAGCCGCCGCCGCTGCTGCTGCCGCTGCCGGGTCGCCAGTGAAGGGAGGCAGTGGCGGCGGCGG
CGAACATGTTTTCAGTAAGGATAGTGACTGCAGACTACTACATGGCCAGCCCGCTGCAGGGGCTGGATACCTGCCAATCCCCCCTCACCC
AGGCCCCTGTCAAGAAGGTGCCGGTGGTGCGAGTCTTCGGAGCGACCCCGGCAGGTCAGAAGACATGTCTTCATCTACATGGCATCTTTC
CTTACCTCTATGTGCCATACGATGGTTATGGACAGCAGCCAGAAAGCTATCTTTCTCAGATGGCATTCAGTATCGACAGAGCACTTAATG
TGGCTTTAGGCAATCCATCTTCCACTGCTCAGCATGTGTTCAAAGTGTCATTAGTATCAGGAATGCCTTTTTATGGTTATCATGAGAAGG
AAAGACACTTTATGAAGATCTATCTTTACAATCCTACAATGGTGAAAAGGATATGTGAACTTTTGCAAAGCGGAGCCATAATGAATAAAT
TTTACCAGCCTCATGAAGCGCATATTCCCTACCTCCTACAGCTCTTCATTGACTACAATCTTTATGGCATGAATTTAATAAATCTGGCTG
CTGTCAAGTTCCGAAAAGCAAGAAGGAAAAGCTTCCAGGTTAAGGTTCTCCGAGAAGACAGCAGAGCTGCTTTCCGCCTCTTTGAGACCA
AGATCACCCAAGTCCTGCACTTCACCAAGGATGTCAAGGCCGCTGCTAATCAGATGCGCAACTTCCTGGTTCGAGCCTCCTGCCGCCTTC
GCTTGGAACCTGGGAAAGAATATTTGATCATGGGTCTGGATGGGGCCACCTATGACCTCGAGGGACACCCCCAGTACCTGCTGGACTCGA
ATAGCTGGATCGAGGAGATGCCCTCTGAACGCCTGTGCCGGAGCACCCGCCAGCGGGCAGCCTGTGCCCAGCTCAACGACTTCCTCCAGG
AGTATGGCACTCAGGGGTGCCAGGTGTGAGGGCTGCCCTCCCACCTCCGCTGGGAGGAACCTGAACCTGGGAACCATGAAGCTGGAAGCA

>73584_73584_1_REV3L-C4B_REV3L_chr6_111726673_ENST00000358835_C4B_chr6_32002291_ENST00000425700_length(amino acids)=307AA_BP=189
MFSVRIVTADYYMASPLQGLDTCQSPLTQAPVKKVPVVRVFGATPAGQKTCLHLHGIFPYLYVPYDGYGQQPESYLSQMAFSIDRALNVA
LGNPSSTAQHVFKVSLVSGMPFYGYHEKERHFMKIYLYNPTMVKRICELLQSGAIMNKFYQPHEAHIPYLLQLFIDYNLYGMNLINLAAV
KFRKARRKSFQVKVLREDSRAAFRLFETKITQVLHFTKDVKAAANQMRNFLVRASCRLRLEPGKEYLIMGLDGATYDLEGHPQYLLDSNS

--------------------------------------------------------------
>73584_73584_2_REV3L-C4B_REV3L_chr6_111726673_ENST00000358835_C4B_chr6_32002291_ENST00000435363_length(transcript)=1520nt_BP=1020nt
CGAGATCTGCGCCTCGCCTCCCTCCTCACGCGGGCGGATTTTCTTACCTTGTGAAAAACCGTCTCAGCGGCTGCCCCCGCCTCCTCTGCT
GGATGTGAAATGGCGGTCGGCGAGTGGTTGCGTCCGTGACATCATCATCATGGCAACAAGAGCTGCAGCCTGGGACCGAGGAGCCCGTGT
GATTCCCGGCGGTGGCGGCAGTGGCGGCAGCACCAGCACCGACGAAAGCTCGAGGGCTTCTCTCCTGCGGCCCCTTGCCGGGTGCTCCTG
AGGAGGCGGCGGCAGCAGCGCCTACACCGCCCCGCCCGCCGCTCCTCGAGGTGCCTCTGTGTGAGGGGAGGGGGCCGTGCCGAGAAGGGG
AGGGGGCGCCGCCGCCGCTGCGGAGGGAGCCGCCGCCGCTGCTGCTGCCGCTGCCGGGTCGCCAGTGAAGGGAGGCAGTGGCGGCGGCGG
CGAACATGTTTTCAGTAAGGATAGTGACTGCAGACTACTACATGGCCAGCCCGCTGCAGGGGCTGGATACCTGCCAATCCCCCCTCACCC
AGGCCCCTGTCAAGAAGGTGCCGGTGGTGCGAGTCTTCGGAGCGACCCCGGCAGGTCAGAAGACATGTCTTCATCTACATGGCATCTTTC
CTTACCTCTATGTGCCATACGATGGTTATGGACAGCAGCCAGAAAGCTATCTTTCTCAGATGGCATTCAGTATCGACAGAGCACTTAATG
TGGCTTTAGGCAATCCATCTTCCACTGCTCAGCATGTGTTCAAAGTGTCATTAGTATCAGGAATGCCTTTTTATGGTTATCATGAGAAGG
AAAGACACTTTATGAAGATCTATCTTTACAATCCTACAATGGTGAAAAGGATATGTGAACTTTTGCAAAGCGGAGCCATAATGAATAAAT
TTTACCAGCCTCATGAAGCGCATATTCCCTACCTCCTACAGCTCTTCATTGACTACAATCTTTATGGCATGAATTTAATAAATCTGGCTG
CTGTCAAGTTCCGAAAAGCAAGAAGGAAAAGCTTCCAGGTTAAGGTTCTCCGAGAAGACAGCAGAGCTGCTTTCCGCCTCTTTGAGACCA
AGATCACCCAAGTCCTGCACTTCACCAAGGATGTCAAGGCCGCTGCTAATCAGATGCGCAACTTCCTGGTTCGAGCCTCCTGCCGCCTTC
GCTTGGAACCTGGGAAAGAATATTTGATCATGGGTCTGGATGGGGCCACCTATGACCTCGAGGGACACCCCCAGTACCTGCTGGACTCGA
ATAGCTGGATCGAGGAGATGCCCTCTGAACGCCTGTGCCGGAGCACCCGCCAGCGGGCAGCCTGTGCCCAGCTCAACGACTTCCTCCAGG
AGTATGGCACTCAGGGGTGCCAGGTGTGAGGGCTGCCCTCCCACCTCCGCTGGGAGGAACCTGAACCTGGGAACCATGAAGCTGGAAGCA

>73584_73584_2_REV3L-C4B_REV3L_chr6_111726673_ENST00000358835_C4B_chr6_32002291_ENST00000435363_length(amino acids)=307AA_BP=189
MFSVRIVTADYYMASPLQGLDTCQSPLTQAPVKKVPVVRVFGATPAGQKTCLHLHGIFPYLYVPYDGYGQQPESYLSQMAFSIDRALNVA
LGNPSSTAQHVFKVSLVSGMPFYGYHEKERHFMKIYLYNPTMVKRICELLQSGAIMNKFYQPHEAHIPYLLQLFIDYNLYGMNLINLAAV
KFRKARRKSFQVKVLREDSRAAFRLFETKITQVLHFTKDVKAAANQMRNFLVRASCRLRLEPGKEYLIMGLDGATYDLEGHPQYLLDSNS

--------------------------------------------------------------
>73584_73584_3_REV3L-C4B_REV3L_chr6_111726673_ENST00000368802_C4B_chr6_32002291_ENST00000425700_length(transcript)=1370nt_BP=888nt
CATCATCATGGCAACAAGAGCTGCAGCCTGGGACCGAGGAGCCCGTGTGATTCCCGGCGGTGGCGGCAGTGGCGGCAGCACCAGCACCGA
CGAAAGCTCGAGGGCTTCTCTCCTGCGGCCCCTTGCCGGGTGCTCCTGAGGAGGCGGCGGCAGCAGCGCCTACACCGCCCCGCCCGCCGC
TCCTCGAGGTGCCTCTGTGTGAGGGGAGGGGGCCGTGCCGAGAAGGGGAGGGGGCGCCGCCGCCGCTGCGGAGGGAGCCGCCGCCGCTGC
TGCTGCCGCTGCCGGGTCGCCAGTGAAGGGAGGCAGTGGCGGCGGCGGCGAACATGTTTTCAGTAAGGATAGTGACTGCAGACTACTACA
TGGCCAGCCCGCTGCAGGGGCTGGATACCTGCCAATCCCCCCTCACCCAGGCCCCTGTCAAGAAGGTGCCGGTGGTGCGAGTCTTCGGAG
CGACCCCGGCAGGTCAGAAGACATGTCTTCATCTACATGGCATCTTTCCTTACCTCTATGTGCCATACGATGGTTATGGACAGCAGCCAG
AAAGCTATCTTTCTCAGATGGCATTCAGTATCGACAGAGCACTTAATGTGGCTTTAGGCAATCCATCTTCCACTGCTCAGCATGTGTTCA
AAGTGTCATTAGTATCAGGAATGCCTTTTTATGGTTATCATGAGAAGGAAAGACACTTTATGAAGATCTATCTTTACAATCCTACAATGG
TGAAAAGGATATGTGAACTTTTGCAAAGCGGAGCCATAATGAATAAATTTTACCAGCCTCATGAAGCGCATATTCCCTACCTCCTACAGC
TCTTCATTGACTACAATCTTTATGGCATGAATTTAATAAATCTGGCTGCTGTCAAGTTCCGAAAAGCAAGAAGGAAAAGCTTCCAGGTTA
AGGTTCTCCGAGAAGACAGCAGAGCTGCTTTCCGCCTCTTTGAGACCAAGATCACCCAAGTCCTGCACTTCACCAAGGATGTCAAGGCCG
CTGCTAATCAGATGCGCAACTTCCTGGTTCGAGCCTCCTGCCGCCTTCGCTTGGAACCTGGGAAAGAATATTTGATCATGGGTCTGGATG
GGGCCACCTATGACCTCGAGGGACACCCCCAGTACCTGCTGGACTCGAATAGCTGGATCGAGGAGATGCCCTCTGAACGCCTGTGCCGGA
GCACCCGCCAGCGGGCAGCCTGTGCCCAGCTCAACGACTTCCTCCAGGAGTATGGCACTCAGGGGTGCCAGGTGTGAGGGCTGCCCTCCC
ACCTCCGCTGGGAGGAACCTGAACCTGGGAACCATGAAGCTGGAAGCACTGCTGTGTCCGCTTTCATGAACACAGCCTGGGACCAGGGCA

>73584_73584_3_REV3L-C4B_REV3L_chr6_111726673_ENST00000368802_C4B_chr6_32002291_ENST00000425700_length(amino acids)=307AA_BP=189
MFSVRIVTADYYMASPLQGLDTCQSPLTQAPVKKVPVVRVFGATPAGQKTCLHLHGIFPYLYVPYDGYGQQPESYLSQMAFSIDRALNVA
LGNPSSTAQHVFKVSLVSGMPFYGYHEKERHFMKIYLYNPTMVKRICELLQSGAIMNKFYQPHEAHIPYLLQLFIDYNLYGMNLINLAAV
KFRKARRKSFQVKVLREDSRAAFRLFETKITQVLHFTKDVKAAANQMRNFLVRASCRLRLEPGKEYLIMGLDGATYDLEGHPQYLLDSNS

--------------------------------------------------------------
>73584_73584_4_REV3L-C4B_REV3L_chr6_111726673_ENST00000368802_C4B_chr6_32002291_ENST00000435363_length(transcript)=1388nt_BP=888nt
CATCATCATGGCAACAAGAGCTGCAGCCTGGGACCGAGGAGCCCGTGTGATTCCCGGCGGTGGCGGCAGTGGCGGCAGCACCAGCACCGA
CGAAAGCTCGAGGGCTTCTCTCCTGCGGCCCCTTGCCGGGTGCTCCTGAGGAGGCGGCGGCAGCAGCGCCTACACCGCCCCGCCCGCCGC
TCCTCGAGGTGCCTCTGTGTGAGGGGAGGGGGCCGTGCCGAGAAGGGGAGGGGGCGCCGCCGCCGCTGCGGAGGGAGCCGCCGCCGCTGC
TGCTGCCGCTGCCGGGTCGCCAGTGAAGGGAGGCAGTGGCGGCGGCGGCGAACATGTTTTCAGTAAGGATAGTGACTGCAGACTACTACA
TGGCCAGCCCGCTGCAGGGGCTGGATACCTGCCAATCCCCCCTCACCCAGGCCCCTGTCAAGAAGGTGCCGGTGGTGCGAGTCTTCGGAG
CGACCCCGGCAGGTCAGAAGACATGTCTTCATCTACATGGCATCTTTCCTTACCTCTATGTGCCATACGATGGTTATGGACAGCAGCCAG
AAAGCTATCTTTCTCAGATGGCATTCAGTATCGACAGAGCACTTAATGTGGCTTTAGGCAATCCATCTTCCACTGCTCAGCATGTGTTCA
AAGTGTCATTAGTATCAGGAATGCCTTTTTATGGTTATCATGAGAAGGAAAGACACTTTATGAAGATCTATCTTTACAATCCTACAATGG
TGAAAAGGATATGTGAACTTTTGCAAAGCGGAGCCATAATGAATAAATTTTACCAGCCTCATGAAGCGCATATTCCCTACCTCCTACAGC
TCTTCATTGACTACAATCTTTATGGCATGAATTTAATAAATCTGGCTGCTGTCAAGTTCCGAAAAGCAAGAAGGAAAAGCTTCCAGGTTA
AGGTTCTCCGAGAAGACAGCAGAGCTGCTTTCCGCCTCTTTGAGACCAAGATCACCCAAGTCCTGCACTTCACCAAGGATGTCAAGGCCG
CTGCTAATCAGATGCGCAACTTCCTGGTTCGAGCCTCCTGCCGCCTTCGCTTGGAACCTGGGAAAGAATATTTGATCATGGGTCTGGATG
GGGCCACCTATGACCTCGAGGGACACCCCCAGTACCTGCTGGACTCGAATAGCTGGATCGAGGAGATGCCCTCTGAACGCCTGTGCCGGA
GCACCCGCCAGCGGGCAGCCTGTGCCCAGCTCAACGACTTCCTCCAGGAGTATGGCACTCAGGGGTGCCAGGTGTGAGGGCTGCCCTCCC
ACCTCCGCTGGGAGGAACCTGAACCTGGGAACCATGAAGCTGGAAGCACTGCTGTGTCCGCTTTCATGAACACAGCCTGGGACCAGGGCA

>73584_73584_4_REV3L-C4B_REV3L_chr6_111726673_ENST00000368802_C4B_chr6_32002291_ENST00000435363_length(amino acids)=307AA_BP=189
MFSVRIVTADYYMASPLQGLDTCQSPLTQAPVKKVPVVRVFGATPAGQKTCLHLHGIFPYLYVPYDGYGQQPESYLSQMAFSIDRALNVA
LGNPSSTAQHVFKVSLVSGMPFYGYHEKERHFMKIYLYNPTMVKRICELLQSGAIMNKFYQPHEAHIPYLLQLFIDYNLYGMNLINLAAV
KFRKARRKSFQVKVLREDSRAAFRLFETKITQVLHFTKDVKAAANQMRNFLVRASCRLRLEPGKEYLIMGLDGATYDLEGHPQYLLDSNS

--------------------------------------------------------------
>73584_73584_5_REV3L-C4B_REV3L_chr6_111726673_ENST00000368805_C4B_chr6_32002291_ENST00000425700_length(transcript)=1130nt_BP=648nt
TGGTTGCGTCCGTGACATCATCATCATGGCAACAAGAGCTGCCGGGTCGCCAGTGAAGGGAGGCAGTGGCGGCGGCGGCGAACATGTTTT
CAGTAAGGATAGTGACTGCAGACTACTACATGGCCAGCCCGCTGCAGGGGCTGGATACCTGCCAATCCCCCCTCACCCAGGCCCCTGTCA
AGAAGGTGCCGGTGGTGCGAGTCTTCGGAGCGACCCCGGCAGGTCAGAAGACATGTCTTCATCTACATGGCATCTTTCCTTACCTCTATG
TGCCATACGATGGTTATGGACAGCAGCCAGAAAGCTATCTTTCTCAGATGGCATTCAGTATCGACAGAGCACTTAATGTGGCTTTAGGCA
ATCCATCTTCCACTGCTCAGCATGTGTTCAAAGTGTCATTAGTATCAGGAATGCCTTTTTATGGTTATCATGAGAAGGAAAGACACTTTA
TGAAGATCTATCTTTACAATCCTACAATGGTGAAAAGGATATGTGAACTTTTGCAAAGCGGAGCCATAATGAATAAATTTTACCAGCCTC
ATGAAGCGCATATTCCCTACCTCCTACAGCTCTTCATTGACTACAATCTTTATGGCATGAATTTAATAAATCTGGCTGCTGTCAAGTTCC
GAAAAGCAAGAAGGAAAAGCTTCCAGGTTAAGGTTCTCCGAGAAGACAGCAGAGCTGCTTTCCGCCTCTTTGAGACCAAGATCACCCAAG
TCCTGCACTTCACCAAGGATGTCAAGGCCGCTGCTAATCAGATGCGCAACTTCCTGGTTCGAGCCTCCTGCCGCCTTCGCTTGGAACCTG
GGAAAGAATATTTGATCATGGGTCTGGATGGGGCCACCTATGACCTCGAGGGACACCCCCAGTACCTGCTGGACTCGAATAGCTGGATCG
AGGAGATGCCCTCTGAACGCCTGTGCCGGAGCACCCGCCAGCGGGCAGCCTGTGCCCAGCTCAACGACTTCCTCCAGGAGTATGGCACTC
AGGGGTGCCAGGTGTGAGGGCTGCCCTCCCACCTCCGCTGGGAGGAACCTGAACCTGGGAACCATGAAGCTGGAAGCACTGCTGTGTCCG

>73584_73584_5_REV3L-C4B_REV3L_chr6_111726673_ENST00000368805_C4B_chr6_32002291_ENST00000425700_length(amino acids)=307AA_BP=189
MFSVRIVTADYYMASPLQGLDTCQSPLTQAPVKKVPVVRVFGATPAGQKTCLHLHGIFPYLYVPYDGYGQQPESYLSQMAFSIDRALNVA
LGNPSSTAQHVFKVSLVSGMPFYGYHEKERHFMKIYLYNPTMVKRICELLQSGAIMNKFYQPHEAHIPYLLQLFIDYNLYGMNLINLAAV
KFRKARRKSFQVKVLREDSRAAFRLFETKITQVLHFTKDVKAAANQMRNFLVRASCRLRLEPGKEYLIMGLDGATYDLEGHPQYLLDSNS

--------------------------------------------------------------
>73584_73584_6_REV3L-C4B_REV3L_chr6_111726673_ENST00000368805_C4B_chr6_32002291_ENST00000435363_length(transcript)=1148nt_BP=648nt
TGGTTGCGTCCGTGACATCATCATCATGGCAACAAGAGCTGCCGGGTCGCCAGTGAAGGGAGGCAGTGGCGGCGGCGGCGAACATGTTTT
CAGTAAGGATAGTGACTGCAGACTACTACATGGCCAGCCCGCTGCAGGGGCTGGATACCTGCCAATCCCCCCTCACCCAGGCCCCTGTCA
AGAAGGTGCCGGTGGTGCGAGTCTTCGGAGCGACCCCGGCAGGTCAGAAGACATGTCTTCATCTACATGGCATCTTTCCTTACCTCTATG
TGCCATACGATGGTTATGGACAGCAGCCAGAAAGCTATCTTTCTCAGATGGCATTCAGTATCGACAGAGCACTTAATGTGGCTTTAGGCA
ATCCATCTTCCACTGCTCAGCATGTGTTCAAAGTGTCATTAGTATCAGGAATGCCTTTTTATGGTTATCATGAGAAGGAAAGACACTTTA
TGAAGATCTATCTTTACAATCCTACAATGGTGAAAAGGATATGTGAACTTTTGCAAAGCGGAGCCATAATGAATAAATTTTACCAGCCTC
ATGAAGCGCATATTCCCTACCTCCTACAGCTCTTCATTGACTACAATCTTTATGGCATGAATTTAATAAATCTGGCTGCTGTCAAGTTCC
GAAAAGCAAGAAGGAAAAGCTTCCAGGTTAAGGTTCTCCGAGAAGACAGCAGAGCTGCTTTCCGCCTCTTTGAGACCAAGATCACCCAAG
TCCTGCACTTCACCAAGGATGTCAAGGCCGCTGCTAATCAGATGCGCAACTTCCTGGTTCGAGCCTCCTGCCGCCTTCGCTTGGAACCTG
GGAAAGAATATTTGATCATGGGTCTGGATGGGGCCACCTATGACCTCGAGGGACACCCCCAGTACCTGCTGGACTCGAATAGCTGGATCG
AGGAGATGCCCTCTGAACGCCTGTGCCGGAGCACCCGCCAGCGGGCAGCCTGTGCCCAGCTCAACGACTTCCTCCAGGAGTATGGCACTC
AGGGGTGCCAGGTGTGAGGGCTGCCCTCCCACCTCCGCTGGGAGGAACCTGAACCTGGGAACCATGAAGCTGGAAGCACTGCTGTGTCCG

>73584_73584_6_REV3L-C4B_REV3L_chr6_111726673_ENST00000368805_C4B_chr6_32002291_ENST00000435363_length(amino acids)=307AA_BP=189
MFSVRIVTADYYMASPLQGLDTCQSPLTQAPVKKVPVVRVFGATPAGQKTCLHLHGIFPYLYVPYDGYGQQPESYLSQMAFSIDRALNVA
LGNPSSTAQHVFKVSLVSGMPFYGYHEKERHFMKIYLYNPTMVKRICELLQSGAIMNKFYQPHEAHIPYLLQLFIDYNLYGMNLINLAAV
KFRKARRKSFQVKVLREDSRAAFRLFETKITQVLHFTKDVKAAANQMRNFLVRASCRLRLEPGKEYLIMGLDGATYDLEGHPQYLLDSNS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for REV3L-C4B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for REV3L-C4B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for REV3L-C4B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource