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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATAD2-WDYHV1 (FusionGDB2 ID:7359)

Fusion Gene Summary for ATAD2-WDYHV1

check button Fusion gene summary
Fusion gene informationFusion gene name: ATAD2-WDYHV1
Fusion gene ID: 7359
HgeneTgene
Gene symbol

ATAD2

WDYHV1

Gene ID

29028

55093

Gene nameATPase family AAA domain containing 2N-terminal glutamine amidase 1
SynonymsANCCA|CT137|PRO2000C8orf32|WDYHV1
Cytomap

8q24.13

8q24.13

Type of geneprotein-codingprotein-coding
DescriptionATPase family AAA domain-containing protein 2AAA nuclear coregulator cancer-associated proteinprotein N-terminal glutamine amidohydrolaseN-terminal Gln amidaseWDYHV motif containing 1WDYHV motif-containing protein 1nt(Q)-amidaseprotein NH2-terminal glutamine deamidase
Modification date2020032220200327
UniProtAcc

Q6PL18

.
Ensembl transtripts involved in fusion geneENST00000287394, ENST00000521903, 
ENST00000534257, 		ENST00000517609, 
ENST00000523356, ENST00000523984, 
ENST00000518125, ENST00000287387, 
Fusion gene scores* DoF score18 X 16 X 9=25924 X 4 X 5=80
# samples 227
** MAII scorelog2(22/2592*10)=-3.55849028935997
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/80*10)=-0.192645077942396
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATAD2 [Title/Abstract] AND WDYHV1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATAD2(124408427)-WDYHV1(124440164), # samples:3
WDYHV1(124429096)-ATAD2(124361684), # samples:1
Anticipated loss of major functional domain due to fusion event.ATAD2-WDYHV1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
ATAD2-WDYHV1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ATAD2-WDYHV1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATAD2

GO:0045893

positive regulation of transcription, DNA-templated

17998543


check buttonFusion gene breakpoints across ATAD2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across WDYHV1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-05-4422-01AATAD2chr8

124392769

-WDYHV1chr8

124440164

+
ChimerDB4SARCTCGA-DX-AB2V-01AATAD2chr8

124384877

-WDYHV1chr8

124448693

+
ChimerDB4UCECTCGA-AX-A3GI-01AATAD2chr8

124408427

-WDYHV1chr8

124440164

+


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Fusion Gene ORF analysis for ATAD2-WDYHV1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000287394ENST00000517609ATAD2chr8

124392769

-WDYHV1chr8

124440164

+
5CDS-3UTRENST00000287394ENST00000517609ATAD2chr8

124384877

-WDYHV1chr8

124448693

+
5CDS-3UTRENST00000287394ENST00000517609ATAD2chr8

124408427

-WDYHV1chr8

124440164

+
5CDS-3UTRENST00000287394ENST00000523356ATAD2chr8

124392769

-WDYHV1chr8

124440164

+
5CDS-3UTRENST00000287394ENST00000523356ATAD2chr8

124384877

-WDYHV1chr8

124448693

+
5CDS-3UTRENST00000287394ENST00000523356ATAD2chr8

124408427

-WDYHV1chr8

124440164

+
5CDS-5UTRENST00000287394ENST00000523984ATAD2chr8

124392769

-WDYHV1chr8

124440164

+
5CDS-5UTRENST00000287394ENST00000523984ATAD2chr8

124408427

-WDYHV1chr8

124440164

+
5CDS-intronENST00000287394ENST00000518125ATAD2chr8

124392769

-WDYHV1chr8

124440164

+
5CDS-intronENST00000287394ENST00000518125ATAD2chr8

124384877

-WDYHV1chr8

124448693

+
5CDS-intronENST00000287394ENST00000518125ATAD2chr8

124408427

-WDYHV1chr8

124440164

+
5UTR-3CDSENST00000521903ENST00000287387ATAD2chr8

124392769

-WDYHV1chr8

124440164

+
5UTR-3CDSENST00000521903ENST00000287387ATAD2chr8

124384877

-WDYHV1chr8

124448693

+
5UTR-3CDSENST00000521903ENST00000523984ATAD2chr8

124384877

-WDYHV1chr8

124448693

+
5UTR-3UTRENST00000521903ENST00000517609ATAD2chr8

124392769

-WDYHV1chr8

124440164

+
5UTR-3UTRENST00000521903ENST00000517609ATAD2chr8

124384877

-WDYHV1chr8

124448693

+
5UTR-3UTRENST00000521903ENST00000523356ATAD2chr8

124392769

-WDYHV1chr8

124440164

+
5UTR-3UTRENST00000521903ENST00000523356ATAD2chr8

124384877

-WDYHV1chr8

124448693

+
5UTR-5UTRENST00000521903ENST00000523984ATAD2chr8

124392769

-WDYHV1chr8

124440164

+
5UTR-intronENST00000521903ENST00000518125ATAD2chr8

124392769

-WDYHV1chr8

124440164

+
5UTR-intronENST00000521903ENST00000518125ATAD2chr8

124384877

-WDYHV1chr8

124448693

+
Frame-shiftENST00000287394ENST00000287387ATAD2chr8

124384877

-WDYHV1chr8

124448693

+
Frame-shiftENST00000287394ENST00000287387ATAD2chr8

124408427

-WDYHV1chr8

124440164

+
Frame-shiftENST00000287394ENST00000523984ATAD2chr8

124384877

-WDYHV1chr8

124448693

+
In-frameENST00000287394ENST00000287387ATAD2chr8

124392769

-WDYHV1chr8

124440164

+
intron-3CDSENST00000521903ENST00000287387ATAD2chr8

124408427

-WDYHV1chr8

124440164

+
intron-3CDSENST00000534257ENST00000287387ATAD2chr8

124392769

-WDYHV1chr8

124440164

+
intron-3CDSENST00000534257ENST00000287387ATAD2chr8

124384877

-WDYHV1chr8

124448693

+
intron-3CDSENST00000534257ENST00000287387ATAD2chr8

124408427

-WDYHV1chr8

124440164

+
intron-3CDSENST00000534257ENST00000523984ATAD2chr8

124384877

-WDYHV1chr8

124448693

+
intron-3UTRENST00000521903ENST00000517609ATAD2chr8

124408427

-WDYHV1chr8

124440164

+
intron-3UTRENST00000521903ENST00000523356ATAD2chr8

124408427

-WDYHV1chr8

124440164

+
intron-3UTRENST00000534257ENST00000517609ATAD2chr8

124392769

-WDYHV1chr8

124440164

+
intron-3UTRENST00000534257ENST00000517609ATAD2chr8

124384877

-WDYHV1chr8

124448693

+
intron-3UTRENST00000534257ENST00000517609ATAD2chr8

124408427

-WDYHV1chr8

124440164

+
intron-3UTRENST00000534257ENST00000523356ATAD2chr8

124392769

-WDYHV1chr8

124440164

+
intron-3UTRENST00000534257ENST00000523356ATAD2chr8

124384877

-WDYHV1chr8

124448693

+
intron-3UTRENST00000534257ENST00000523356ATAD2chr8

124408427

-WDYHV1chr8

124440164

+
intron-5UTRENST00000521903ENST00000523984ATAD2chr8

124408427

-WDYHV1chr8

124440164

+
intron-5UTRENST00000534257ENST00000523984ATAD2chr8

124392769

-WDYHV1chr8

124440164

+
intron-5UTRENST00000534257ENST00000523984ATAD2chr8

124408427

-WDYHV1chr8

124440164

+
intron-intronENST00000521903ENST00000518125ATAD2chr8

124408427

-WDYHV1chr8

124440164

+
intron-intronENST00000534257ENST00000518125ATAD2chr8

124392769

-WDYHV1chr8

124440164

+
intron-intronENST00000534257ENST00000518125ATAD2chr8

124384877

-WDYHV1chr8

124448693

+
intron-intronENST00000534257ENST00000518125ATAD2chr8

124408427

-WDYHV1chr8

124440164

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ATAD2-WDYHV1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ATAD2chr8124384876-WDYHV1chr8124448692+7.01E-050.9999299
ATAD2chr8124392768-WDYHV1chr8124440163+4.68E-091
ATAD2chr8124408426-WDYHV1chr8124440163+7.59E-111
ATAD2chr8124384876-WDYHV1chr8124448692+7.01E-050.9999299
ATAD2chr8124392768-WDYHV1chr8124440163+4.68E-091
ATAD2chr8124408426-WDYHV1chr8124440163+7.59E-111

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ATAD2-WDYHV1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:124408427/chr8:124440164)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATAD2

Q6PL18

.
FUNCTION: May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. {ECO:0000269|PubMed:17998543}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATAD2chr8:124392769chr8:124440164ENST00000287394-2281086_11121061391.0Coiled coilOntology_term=ECO:0000255
HgeneATAD2chr8:124392769chr8:124440164ENST00000287394-228970_9941061391.0Coiled coilOntology_term=ECO:0000255
HgeneATAD2chr8:124392769chr8:124440164ENST00000287394-228250_2851061391.0Compositional biasNote=Asp-rich
HgeneATAD2chr8:124392769chr8:124440164ENST00000287394-228357_3661061391.0Compositional biasNote=Poly-Ser
HgeneATAD2chr8:124392769chr8:124440164ENST00000287394-2281001_10711061391.0DomainBromo
HgeneATAD2chr8:124392769chr8:124440164ENST00000287394-228467_4741061391.0Nucleotide bindingATP


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Fusion Gene Sequence for ATAD2-WDYHV1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ATAD2-WDYHV1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATAD2-WDYHV1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATAD2-WDYHV1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource