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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:REV3L-PDE10A (FusionGDB2 ID:73592)

Fusion Gene Summary for REV3L-PDE10A

check button Fusion gene summary
Fusion gene informationFusion gene name: REV3L-PDE10A
Fusion gene ID: 73592
HgeneTgene
Gene symbol

REV3L

PDE10A

Gene ID

5980

10846

Gene nameREV3 like, DNA directed polymerase zeta catalytic subunitphosphodiesterase 10A
SynonymsPOLZ|REV3ADSD2|HSPDE10A|IOLOD|LINC00473|PDE10A19
Cytomap

6q21

6q27

Type of geneprotein-codingprotein-coding
DescriptionDNA polymerase zeta catalytic subunitREV3-like, polymerase (DNA directed), zeta, catalytic subunitRev-3, yeast, homolog-like (polymerase, DNA, zeta)cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3',5' cAMP/cGMP phosphodiesterasedJ416F21.1 (phosphodiesterase 10A)phosphodiesterase 10A1 (PDE10A1)phosphodiesterase 10A7 (PDE10A7)
Modification date2020031320200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000358835, ENST00000368802, 
ENST00000368805, ENST00000435970, 
ENST00000462119, 		ENST00000535229, 
ENST00000354448, ENST00000366882, 
ENST00000539869, 
Fusion gene scores* DoF score17 X 20 X 10=34008 X 7 X 4=224
# samples 268
** MAII scorelog2(26/3400*10)=-3.70895121799661
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/224*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: REV3L [Title/Abstract] AND PDE10A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointREV3L(111803952)-PDE10A(165832265), # samples:1
Anticipated loss of major functional domain due to fusion event.REV3L-PDE10A seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
REV3L-PDE10A seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
REV3L-PDE10A seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across REV3L (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PDE10A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-TM-A84BREV3Lchr6

111803952

-PDE10Achr6

165832265

-


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Fusion Gene ORF analysis for REV3L-PDE10A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000358835ENST00000535229REV3Lchr6

111803952

-PDE10Achr6

165832265

-
5CDS-intronENST00000368802ENST00000535229REV3Lchr6

111803952

-PDE10Achr6

165832265

-
5CDS-intronENST00000368805ENST00000535229REV3Lchr6

111803952

-PDE10Achr6

165832265

-
5UTR-3CDSENST00000435970ENST00000354448REV3Lchr6

111803952

-PDE10Achr6

165832265

-
5UTR-3CDSENST00000435970ENST00000366882REV3Lchr6

111803952

-PDE10Achr6

165832265

-
5UTR-3CDSENST00000435970ENST00000539869REV3Lchr6

111803952

-PDE10Achr6

165832265

-
5UTR-intronENST00000435970ENST00000535229REV3Lchr6

111803952

-PDE10Achr6

165832265

-
Frame-shiftENST00000358835ENST00000354448REV3Lchr6

111803952

-PDE10Achr6

165832265

-
Frame-shiftENST00000358835ENST00000366882REV3Lchr6

111803952

-PDE10Achr6

165832265

-
Frame-shiftENST00000358835ENST00000539869REV3Lchr6

111803952

-PDE10Achr6

165832265

-
Frame-shiftENST00000368805ENST00000354448REV3Lchr6

111803952

-PDE10Achr6

165832265

-
Frame-shiftENST00000368805ENST00000366882REV3Lchr6

111803952

-PDE10Achr6

165832265

-
Frame-shiftENST00000368805ENST00000539869REV3Lchr6

111803952

-PDE10Achr6

165832265

-
In-frameENST00000368802ENST00000354448REV3Lchr6

111803952

-PDE10Achr6

165832265

-
In-frameENST00000368802ENST00000366882REV3Lchr6

111803952

-PDE10Achr6

165832265

-
In-frameENST00000368802ENST00000539869REV3Lchr6

111803952

-PDE10Achr6

165832265

-
intron-3CDSENST00000462119ENST00000354448REV3Lchr6

111803952

-PDE10Achr6

165832265

-
intron-3CDSENST00000462119ENST00000366882REV3Lchr6

111803952

-PDE10Achr6

165832265

-
intron-3CDSENST00000462119ENST00000539869REV3Lchr6

111803952

-PDE10Achr6

165832265

-
intron-intronENST00000462119ENST00000535229REV3Lchr6

111803952

-PDE10Achr6

165832265

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000368802REV3Lchr6111803952-ENST00000366882PDE10Achr6165832265-77154623451976543
ENST00000368802REV3Lchr6111803952-ENST00000354448PDE10Achr6165832265-77134623451976543
ENST00000368802REV3Lchr6111803952-ENST00000539869PDE10Achr6165832265-39524623451976543

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000368802ENST00000366882REV3Lchr6111803952-PDE10Achr6165832265-0.0001935610.99980646
ENST00000368802ENST00000354448REV3Lchr6111803952-PDE10Achr6165832265-0.0001926270.9998074
ENST00000368802ENST00000539869REV3Lchr6111803952-PDE10Achr6165832265-0.0004214440.99957854

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Fusion Genomic Features for REV3L-PDE10A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for REV3L-PDE10A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:111803952/chr6:165832265)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePDE10Achr6:111803952chr6:165832265ENST00000354448922442_759275780.0DomainPDEase
TgenePDE10Achr6:111803952chr6:165832265ENST000003668821023442_759275780.0DomainPDEase
TgenePDE10Achr6:111803952chr6:165832265ENST00000539869922442_759285790.0DomainPDEase
TgenePDE10Achr6:111803952chr6:165832265ENST00000354448922286_287275780.0Region3'%2C5'-cAMP binding
TgenePDE10Achr6:111803952chr6:165832265ENST00000354448922330_331275780.0Region3'%2C5'-cAMP binding
TgenePDE10Achr6:111803952chr6:165832265ENST000003668821023286_287275780.0Region3'%2C5'-cAMP binding
TgenePDE10Achr6:111803952chr6:165832265ENST000003668821023330_331275780.0Region3'%2C5'-cAMP binding
TgenePDE10Achr6:111803952chr6:165832265ENST00000539869922286_287285790.0Region3'%2C5'-cAMP binding
TgenePDE10Achr6:111803952chr6:165832265ENST00000539869922330_331285790.0Region3'%2C5'-cAMP binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneREV3Lchr6:111803952chr6:165832265ENST00000358835-2333086_3104463131.0MotifNote=CysB motif
HgeneREV3Lchr6:111803952chr6:165832265ENST00000368802-1323086_3104463131.0MotifNote=CysB motif
HgeneREV3Lchr6:111803952chr6:165832265ENST00000368805-2333086_3104463131.0MotifNote=CysB motif
HgeneREV3Lchr6:111803952chr6:165832265ENST00000435970-2343086_310403053.0MotifNote=CysB motif
HgeneREV3Lchr6:111803952chr6:165832265ENST00000358835-2333042_3057463131.0Zinc fingerNote=CysA-type
HgeneREV3Lchr6:111803952chr6:165832265ENST00000368802-1323042_3057463131.0Zinc fingerNote=CysA-type
HgeneREV3Lchr6:111803952chr6:165832265ENST00000368805-2333042_3057463131.0Zinc fingerNote=CysA-type
HgeneREV3Lchr6:111803952chr6:165832265ENST00000435970-2343042_305703053.0Zinc fingerNote=CysA-type
TgenePDE10Achr6:111803952chr6:165832265ENST00000354448922266_412275780.0DomainNote=GAF 2
TgenePDE10Achr6:111803952chr6:165832265ENST0000035444892291_234275780.0DomainNote=GAF 1
TgenePDE10Achr6:111803952chr6:165832265ENST000003668821023266_412275780.0DomainNote=GAF 2
TgenePDE10Achr6:111803952chr6:165832265ENST00000366882102391_234275780.0DomainNote=GAF 1
TgenePDE10Achr6:111803952chr6:165832265ENST00000539869922266_412285790.0DomainNote=GAF 2
TgenePDE10Achr6:111803952chr6:165832265ENST0000053986992291_234285790.0DomainNote=GAF 1


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Fusion Gene Sequence for REV3L-PDE10A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>73592_73592_1_REV3L-PDE10A_REV3L_chr6_111803952_ENST00000368802_PDE10A_chr6_165832265_ENST00000354448_length(transcript)=7713nt_BP=462nt
CATCATCATGGCAACAAGAGCTGCAGCCTGGGACCGAGGAGCCCGTGTGATTCCCGGCGGTGGCGGCAGTGGCGGCAGCACCAGCACCGA
CGAAAGCTCGAGGGCTTCTCTCCTGCGGCCCCTTGCCGGGTGCTCCTGAGGAGGCGGCGGCAGCAGCGCCTACACCGCCCCGCCCGCCGC
TCCTCGAGGTGCCTCTGTGTGAGGGGAGGGGGCCGTGCCGAGAAGGGGAGGGGGCGCCGCCGCCGCTGCGGAGGGAGCCGCCGCCGCTGC
TGCTGCCGCTGCCGGGTCGCCAGTGAAGGGAGGCAGTGGCGGCGGCGGCGAACATGTTTTCAGTAAGGATAGTGACTGCAGACTACTACA
TGGCCAGCCCGCTGCAGGGGCTGGATACCTGCCAATCCCCCCTCACCCAGGCCCCTGTCAAGAAGGTGCCGGTGGTGCGAGTCTTCGGAG
CGACCCCGGCAGATATATGCAAAAAACCTGGTGAATGCCGATCGTTGTGCGCTTTTCCAGGTGGACCATAAGAACAAGGAGTTATATTCA
GACCTTTTTGATATTGGAGAGGAAAAGGAAGGAAAACCTGTCTTCAAGAAGACCAAAGAGATAAGATTTTCAATTGAGAAAGGAATTGCT
GGCCAAGTAGCAAGAACAGGGGAAGTCCTGAACATTCCAGATGCCTATGCAGACCCACGCTTTAACAGAGAAGTAGACTTGTACACAGGC
TACACCACGCGGAACATCCTGTGCATGCCCATCGTCAGCCGAGGCAGCGTGATAGGTGTGGTGCAGATGGTCAACAAAATCAGTGGCAGT
GCCTTCTCTAAAACAGATGAAAACAACTTCAAAATGTTTGCCGTCTTTTGTGCTTTAGCCTTACACTGTGCTAATATGTATCATAGAATT
CGCCACTCAGAGTGCATTTACCGGGTAACGATGGAAAAGCTGTCCTACCATAGCATTTGTACTTCAGAAGAGTGGCAAGGTCTCATGCAA
TTCACCCTTCCCGTGCGTCTCTGCAAAGAAATTGAATTATTCCACTTTGACATTGGTCCTTTTGAAAACATGTGGCCTGGAATTTTTGTC
TACATGGTTCATCGGTCCTGTGGGACATCCTGCTTTGAGCTTGAAAAGTTGTGTCGTTTTATTATGTCTGTGAAGAAGAACTATCGGCGG
GTTCCTTATCACAACTGGAAGCATGCGGTCACTGTAGCACACTGCATGTATGCCATACTTCAGAACAATCACACGCTTTTCACAGACCTT
GAGCGCAAAGGACTGCTGATTGCGTGTCTGTGTCATGACCTGGACCACAGGGGCTTCAGTAACAGCTACCTGCAGAAGTTCGACCACCCT
CTGGCCGCTCTCTACTCCACTTCCACCATGGAGCAGCACCACTTCTCCCAGACTGTGTCCATCCTCCAGTTGGAAGGGCACAATATCTTC
TCCACTCTGAGCTCCAGTGAATATGAGCAGGTGCTTGAGATCATCCGCAAAGCCATCATTGCCACAGACCTTGCTTTATACTTTGGAAAC
AGGAAGCAGTTGGAAGAGATGTACCAGACCGGATCACTAAACCTTAATAATCAATCACATAGAGACCGTGTAATTGGTTTGATGATGACT
GCCTGTGACCTTTGTTCTGTGACAAAACTGTGGCCCGTTACAAAATTGACGGCAAATGATATATATGCAGAATTCTGGGCTGAGGGTGAT
GAAATGAAGAAATTGGGAATACAGCCTATTCCTATGATGGACAGAGACAAGAAGGATGAAGTCCCCCAAGGCCAGCTTGGGTTCTACAAT
GCCGTGGCCATTCCCTGCTATACAACCCTTACCCAGATCCTCCCTCCCACGGAGCCTCTTCTGAAAGCATGCAGGGATAATCTCAGTCAG
TGGGAGAAGGTGATTCGAGGGGAGGAGACTGCAACCTGGATTTCATCCCCATCCGTGGCTCAGAAGGCAGCTGCATCTGAAGATTGAGCA
CTGGTCACCCTGACACGCTGTCCCACCTACAGATCCTCATCTTGCTTCTTTGACATTCTTTTCCTTTTTTTGGGGGGGGTGGGGGGAACC
TGCACCTGGTAACTGGGGTGCAAACCTCTTCAAGAAGGTAACATCAAATAAATAAGTCAAGCAGAGGACTTCCTGCCAATCTCTTCTGTG
AGGCATCATAGACACTGAGCAACCAGGACCACCCCCACGTTCAGAAATCAGCTGGCCAAGTGACTCCATTTGACTTGCAAACCAGCCTTT
TCTAATAGGCTAATATTGCTGAGGCCTTAAAGGAAATGGACAAAAATTATCCAGAAGGGGTACTTTTCCATTGTATCTTTCTAATAAGGG
TTTAAAATGGTACTATTATGGTATTGTACTTGGGCTTTAACATCAATGTTGCTTTGATGTTGTTGGATATAAATAGGAATTTTTACACAT
TACTATTGTGAATGGTGAATGTTCATGTATGACCTACTTGTAATTAACTTGAGTTGTAGTCCACAGCCTCAGGACAAATGTCGTTGAGGT
TACAGAGTAAGAAATGATGGCAAAACGTCAAACTCTTATTTCAGAGCTTCATGAATTTAGTTAGACTAAACATAATTCTTTAAGTTCAAC
CTAAAGGGCTGAGATCAATAAATTTAACACTAGACGAAGTAGACTTCCTGTCTTTTTGAGAAGAGATGAGGTATATGTTACAATAAATCT
CAGAACTTCAAGTAGCAGTTCAAAAGATGTCAGTTTTTAAAATTGTTTTTGTTGTTGTCTTGGCAGTTTTACTGAACCCTTTGCATAAAG
AACAAAATAAAAGCTCGGCATTGTAATTTTTTTAATGGACAAGTCTTATGGATACGAAGGGTACATTTTTCATAATGATTCCTTTATATT
TTCACTTTGTGTCATTGCAGAATTTTAGACTCTCATTCACAATGAAAAGTTTATTTTAAACATTGTTTAATTAAAATACCATACAGTTCT
CTTTTAAACATCAAACCATAAAAAGTGTATTTTGTAATTTTACTCTGACCTGCCGCAGTCACCTCTCACTTATCTCTTCCACGTACTGCA
CGGTCGTATTTCATGAGCTTTCTGTCCATAGCACAGAAACAGAGCAGAAAGTAGTACAATCATGTTGGACCTTCTTTCTGTTCTCTTTAC
TCTTCTCACAGATCAGATCACTCCATAGAAGCCTGTGGGTTTCGATGGTTTCTTCTATACACCTTTTTGGTTGACCAGTATTACTATACA
ATGTAAGTGTTTTAAAAAATACGAAAGTAATACTCTGCACCCCTTCCTACAAAGATGATAAAGCAGTCACTTCTGGCGCATTTTAATAAT
TTAAAGATTTTTAGTGCAATGGCACGGTAACCTCCAAACCTGAATTAGACAGAGACTCACTCAGGAAGTGACAGGCCCATCATATCAAAT
AACTTATTCACTTTTCATGTGGCAGGAAACTGGAATATCGCTTTTAATAAAATGGAAAAATATGCTTCTACATATTTACCACCATAGGCG
TTTTGTTCATATGAGCCTGGTTTGTGCAAAATTAAATCAGAGGCTTCTACAACATGGTTTATTTATGTTGTAGCAAAGTTGGCTCTACAT
AAACATTGTTCTTATTTTAAAATTAACACTATGTGTTCAGTTTTCTTGTGGGCTTCTGAAAGTTGCCATCTTCCCTCCGTGGAGCTCCAT
TTGCTATTTTCATTATACACTATGAGGTAAAATGTAATAACAAAAGAGAGAGAAGTACCACTGTGGCTAGATATATACACACACATATAT
ATATGGATGGATGTAATATATGTAGAACACACACATAGATGTATATAGGATACACACTCATGTATGTAAACGTATACATATGTGTATATA
TGATACATACACATACACACACACGAGAGACAGAAGGAAAGAGAGGAAGAGAGAAGCAAACATGTAGGAAAAAATATAAATCAGCCCCAT
TCTCCCATTCTTTAAGAACAATGATTTTTCTTGATGGAAAATGCATATCACTTGACAGTTGACAAGAAAGTGTCATTTTTGTGTTAGTGT
ATCATATAATTGAATTTGAACAAGATACATATTTTTCTGCATACAAATTTATGAAGCTGGAGTCTACCAAACACAGCTTTAGTCACAAAA
GTTAGTTTAGTTATCTCATTTCGCTTGGAGATGGAATTTCAGGAAGGGATATATTATTTAAGATTATTGTTTAATTACAAGAATTTTAAA
AGAATGTATGAATTCTGTTTTTTAATATAGAAAATAATTATGGAGTTAGGAATCTCATGGCTACATTTACATTTTTAGGTTATTACAGAA
AATTCTCTTAATTTATTATAGTCAAGTGTATTATGTAATCTCTATTTAGAACAGTTTCCCAAAGGAATGTGATTGGATTTACTGGTTGGT
TAATTTCTTGTGAAATATTGTCATAATAGAAGCACAGCTTGAACAAAAGACTGAATTCTGATATAAACTGTCAATATTGCTTTTACCATG
TGTAAGATTTACTTAGTAATCACAGATTTACCTAAAATAAAAGGACCCGGGTTGCAGTGATATTTAGTTAATGATTTGTTTTGGAAAACA
TGCAGTTAGGAGTATTTTTGTATTTTGTCAGATGTTTAGGAGACAGACTTTCGGGTCATGTTTCTTGTCTTGTTCCCAGATCTTTTCTTA
AAAGAACAGTGTGACACCAGAAGCCAAGAGATGGTTTTTACTAACAACAGCTTTGATGAGTTCCTATTAAGGTCGTATTGTGTATTGTGC
CAAATTTTCCACCCAGTATAAATTTAGTAACCCGCTATGAGCATATGTAGGATATTCAATTTGCAGATACTTTTGTTGGTTATGTTGGTT
TATAATAGACAAGTTTTATGGTCATATGCAATTATTCCATTATCTTTTTGGACACAGTGAATATGTTTTTTAGCTAAAAATGTCCTTGGA
AACATAAATGCCTGCCAATAACATGGAATATTGAATTCGGGCAATGTGAATTGATTAATTAGAAAAGGGTCAAAAGAAATACAATGGATG
TGGAAACTAATTCTAAAAAATAGCCCTATTAATAGGGCAGAGACTCTGGTCCATTTCCCAGCTGTACTTCTCTCTAAGAGGTGTATGAAA
AACCCATCTTGCAAAAGAGACCAAAATATTAGACACAATCGTTCCCATTCCTGACTCTTCAATGGAAAAGGAAGGTACAGATGTTTACAG
TGGTGCCCCAGGTGACTCGTTCTCACCACAACAAAAGCAACTAATTGGAAACTAGATGTGTTCAATAATAGATTTCCTCTTTTTTGGCAT
GCTTTTTAGATTTTTTTTCATTTTGTAAAATCTCAGTTAATTTTTCTTTATTGGTATATTTGTGTATGCGAGACAAATCCTGTATTGTAC
AGGATATAAATAGATGCATAAATCCTTAGATACCTGGGTTTTTTAATAGGTTTAGGTTTGGGTATTGTGTTTCTGGTCTTTTAACTCAAA
ATTAAGGTTTGAGCTTTAATAGGACTAAATTATTCACCTGCCTTGGCCTGTGCCTTTATTTTAAATACTGCAATTTTACTTCTTCATTCA
TGTATTTATTATTTTGCTTTTCTTGCTTAAGTATAATTGAAAATATTTGCAGGAACGCACAATTCATTTTATCAAGTTGAATGAATAGGA
CCATTCTCTCCTCATCAGATTTCTGTTCTTTATTTGACTTCATTGACATATACCCTGGTGACTATAACCAGTGAACTGTTCAGAGTCAGT
CTTTTCGGCAAGAACTTCAGAGAACTGTGACACTGGTTATGATGTGATTTTGGGGGGTTTCAGGTACCTAAGCATGATTTTTAAAATCAC
TTCTCTCTTTACATATTTCGAACATATGTTTGCTTTCTACACTTTGCAGATTTTATTTAGGATTTAATTCTTTAAAGACTATATTCATTT
AGTCACTATAGTGGATCTCTTCTACTGCAAGTATTCATCTGATTTTTAAATTATGTAAAATGTAAATCAGCCAAGTATGTCATCCGTTAT
AGTTTCCCCATGCTTTCAGCGCATGGCCATGAGATTTTTACATGTGCATAAGTATTTAGCCAATACACATTTTGCTGACTTCTTTAACCA
TTTATATTGTTTAAATTAGTAATATCCAATGCAGTGCACACTTTTTTGTCTTTTTTCCAACGGAATATTTTGGTTGTCTGTAGCGTTGGA
AGCATTTTATATGATAAAAATAGCAAGAAAAAATTAAAAAGTGTCAACGGTGTGCTGGTTCTAAATTAAGAAGATAGAACAAAGAGAAAG
ACATTAATGTTACCTAAGAAACACATTTAACATCCGAAGAAGCAATGCTGTCCTCACTTGATGTTTCTCTTCTCAACCCAGCAATGGAGA
GCAGGGCTTGCAAAGCCGTACAGAGCCTACGTGCTCTTTCCTGCAAGTGGGAGAAAACTAATCAATGGCACACAGGGCCAGGTGTGGCCC
TGTGAGGCAAAGGATAATGTCACCTCAGGACCAAGGTGGAAACTTACAGCTGAATCCAGGGCTTACTAAGTAGGGAAGTCAGTTTACATA
TTTCAGTTTTCCTCTGATGTTTTTGAGGTACTGTGTATTTGCAGAAGTTTAAGCAGAAGGGTTTTGTTTCTATTGTAAGTTAGGTTCTAA
AAGTGTATAATCTGATACTCTAGCCCAACTGAAATATTATATCTTGGGCGTTACAGCCTTTGTCTTTTTCTTTAGTCACCTTAATACCCA
GTCCTATGCTGTATCTCTGATAGCCTATATAAATGACATATAGGAATATTATTTTCCATATGATCTGTTGTATGGTGTATATGCTATGTG
TTCATTTCGTGTGCAAGTTCAGAGTGTAATAGATTTACCCAGAGAAGGTGTTTCTATACAATGCCCCTACCTATTTGAAATTACATGCTT
GCCCAACACACTGTGAAATAGTTACCAAAATTTGTACAAATGCAGCATCTTCATTCTTTCTGAGAAGACAAGATGGTTTTCTTTACATGA
ACAAATGAACAAAAGAGATCCTAGATCCATAACGTAGCTAAGGCATCTAAGAGTTTGCTGTTGATAATCTTGCTGACCAAAAACTACTGG
AGAGTAACACAGGTTATATGCCATCACAAATACAATGCTCATGAAGAACTGATTTGTAGAGTCAATGAACCTGTGTCCAGAATTTTAATA
GGCTCTCTATTGGAAGGAGAAAGAATTTCAAGTTAACAGTATCTAACTTTATCATAGTTGATGTTAGTAAATTTTAAAAAATGATTTTAT
ATGTATGACAAAAATCTTTGTAAAATGCGCAAGTGCAATAATTTAAAGAGGTCTTAACTTTGCATTTATAAATTATAAATATTGTACATG
TGTGTAATTTTTTCATGTATTCATTTGCAGTCTTTGTATTTAAAAAACATTTACTGTTATGTTTGTATAATAGAACAGTAATCATTTATT
ATAATCTAGGCAAGTTGTAAATAAATTCATAATTCAAACAGCCAGTATATATGCATATATGAGTGTTATATTGCAAAATCTTTGTTTTAC
TTACATGGTTAAAGCAGCAAGAATTCTTTTGTTGATATGTAATTATACACATAAAATATATATATGTATGATACATGAAATATATTTAGA

>73592_73592_1_REV3L-PDE10A_REV3L_chr6_111803952_ENST00000368802_PDE10A_chr6_165832265_ENST00000354448_length(amino acids)=543AA_BP=39
MQTTTWPARCRGWIPANPPSPRPLSRRCRWCESSERPRQIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFSI
EKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCAN
MYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVK
KNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLE
GHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEF
WAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAA

--------------------------------------------------------------
>73592_73592_2_REV3L-PDE10A_REV3L_chr6_111803952_ENST00000368802_PDE10A_chr6_165832265_ENST00000366882_length(transcript)=7715nt_BP=462nt
CATCATCATGGCAACAAGAGCTGCAGCCTGGGACCGAGGAGCCCGTGTGATTCCCGGCGGTGGCGGCAGTGGCGGCAGCACCAGCACCGA
CGAAAGCTCGAGGGCTTCTCTCCTGCGGCCCCTTGCCGGGTGCTCCTGAGGAGGCGGCGGCAGCAGCGCCTACACCGCCCCGCCCGCCGC
TCCTCGAGGTGCCTCTGTGTGAGGGGAGGGGGCCGTGCCGAGAAGGGGAGGGGGCGCCGCCGCCGCTGCGGAGGGAGCCGCCGCCGCTGC
TGCTGCCGCTGCCGGGTCGCCAGTGAAGGGAGGCAGTGGCGGCGGCGGCGAACATGTTTTCAGTAAGGATAGTGACTGCAGACTACTACA
TGGCCAGCCCGCTGCAGGGGCTGGATACCTGCCAATCCCCCCTCACCCAGGCCCCTGTCAAGAAGGTGCCGGTGGTGCGAGTCTTCGGAG
CGACCCCGGCAGATATATGCAAAAAACCTGGTGAATGCCGATCGTTGTGCGCTTTTCCAGGTGGACCATAAGAACAAGGAGTTATATTCA
GACCTTTTTGATATTGGAGAGGAAAAGGAAGGAAAACCTGTCTTCAAGAAGACCAAAGAGATAAGATTTTCAATTGAGAAAGGAATTGCT
GGCCAAGTAGCAAGAACAGGGGAAGTCCTGAACATTCCAGATGCCTATGCAGACCCACGCTTTAACAGAGAAGTAGACTTGTACACAGGC
TACACCACGCGGAACATCCTGTGCATGCCCATCGTCAGCCGAGGCAGCGTGATAGGTGTGGTGCAGATGGTCAACAAAATCAGTGGCAGT
GCCTTCTCTAAAACAGATGAAAACAACTTCAAAATGTTTGCCGTCTTTTGTGCTTTAGCCTTACACTGTGCTAATATGTATCATAGAATT
CGCCACTCAGAGTGCATTTACCGGGTAACGATGGAAAAGCTGTCCTACCATAGCATTTGTACTTCAGAAGAGTGGCAAGGTCTCATGCAA
TTCACCCTTCCCGTGCGTCTCTGCAAAGAAATTGAATTATTCCACTTTGACATTGGTCCTTTTGAAAACATGTGGCCTGGAATTTTTGTC
TACATGGTTCATCGGTCCTGTGGGACATCCTGCTTTGAGCTTGAAAAGTTGTGTCGTTTTATTATGTCTGTGAAGAAGAACTATCGGCGG
GTTCCTTATCACAACTGGAAGCATGCGGTCACTGTAGCACACTGCATGTATGCCATACTTCAGAACAATCACACGCTTTTCACAGACCTT
GAGCGCAAAGGACTGCTGATTGCGTGTCTGTGTCATGACCTGGACCACAGGGGCTTCAGTAACAGCTACCTGCAGAAGTTCGACCACCCT
CTGGCCGCTCTCTACTCCACTTCCACCATGGAGCAGCACCACTTCTCCCAGACTGTGTCCATCCTCCAGTTGGAAGGGCACAATATCTTC
TCCACTCTGAGCTCCAGTGAATATGAGCAGGTGCTTGAGATCATCCGCAAAGCCATCATTGCCACAGACCTTGCTTTATACTTTGGAAAC
AGGAAGCAGTTGGAAGAGATGTACCAGACCGGATCACTAAACCTTAATAATCAATCACATAGAGACCGTGTAATTGGTTTGATGATGACT
GCCTGTGACCTTTGTTCTGTGACAAAACTGTGGCCCGTTACAAAATTGACGGCAAATGATATATATGCAGAATTCTGGGCTGAGGGTGAT
GAAATGAAGAAATTGGGAATACAGCCTATTCCTATGATGGACAGAGACAAGAAGGATGAAGTCCCCCAAGGCCAGCTTGGGTTCTACAAT
GCCGTGGCCATTCCCTGCTATACAACCCTTACCCAGATCCTCCCTCCCACGGAGCCTCTTCTGAAAGCATGCAGGGATAATCTCAGTCAG
TGGGAGAAGGTGATTCGAGGGGAGGAGACTGCAACCTGGATTTCATCCCCATCCGTGGCTCAGAAGGCAGCTGCATCTGAAGATTGAGCA
CTGGTCACCCTGACACGCTGTCCCACCTACAGATCCTCATCTTGCTTCTTTGACATTCTTTTCCTTTTTTTGGGGGGGGTGGGGGGAACC
TGCACCTGGTAACTGGGGTGCAAACCTCTTCAAGAAGGTAACATCAAATAAATAAGTCAAGCAGAGGACTTCCTGCCAATCTCTTCTGTG
AGGCATCATAGACACTGAGCAACCAGGACCACCCCCACGTTCAGAAATCAGCTGGCCAAGTGACTCCATTTGACTTGCAAACCAGCCTTT
TCTAATAGGCTAATATTGCTGAGGCCTTAAAGGAAATGGACAAAAATTATCCAGAAGGGGTACTTTTCCATTGTATCTTTCTAATAAGGG
TTTAAAATGGTACTATTATGGTATTGTACTTGGGCTTTAACATCAATGTTGCTTTGATGTTGTTGGATATAAATAGGAATTTTTACACAT
TACTATTGTGAATGGTGAATGTTCATGTATGACCTACTTGTAATTAACTTGAGTTGTAGTCCACAGCCTCAGGACAAATGTCGTTGAGGT
TACAGAGTAAGAAATGATGGCAAAACGTCAAACTCTTATTTCAGAGCTTCATGAATTTAGTTAGACTAAACATAATTCTTTAAGTTCAAC
CTAAAGGGCTGAGATCAATAAATTTAACACTAGACGAAGTAGACTTCCTGTCTTTTTGAGAAGAGATGAGGTATATGTTACAATAAATCT
CAGAACTTCAAGTAGCAGTTCAAAAGATGTCAGTTTTTAAAATTGTTTTTGTTGTTGTCTTGGCAGTTTTACTGAACCCTTTGCATAAAG
AACAAAATAAAAGCTCGGCATTGTAATTTTTTTAATGGACAAGTCTTATGGATACGAAGGGTACATTTTTCATAATGATTCCTTTATATT
TTCACTTTGTGTCATTGCAGAATTTTAGACTCTCATTCACAATGAAAAGTTTATTTTAAACATTGTTTAATTAAAATACCATACAGTTCT
CTTTTAAACATCAAACCATAAAAAGTGTATTTTGTAATTTTACTCTGACCTGCCGCAGTCACCTCTCACTTATCTCTTCCACGTACTGCA
CGGTCGTATTTCATGAGCTTTCTGTCCATAGCACAGAAACAGAGCAGAAAGTAGTACAATCATGTTGGACCTTCTTTCTGTTCTCTTTAC
TCTTCTCACAGATCAGATCACTCCATAGAAGCCTGTGGGTTTCGATGGTTTCTTCTATACACCTTTTTGGTTGACCAGTATTACTATACA
ATGTAAGTGTTTTAAAAAATACGAAAGTAATACTCTGCACCCCTTCCTACAAAGATGATAAAGCAGTCACTTCTGGCGCATTTTAATAAT
TTAAAGATTTTTAGTGCAATGGCACGGTAACCTCCAAACCTGAATTAGACAGAGACTCACTCAGGAAGTGACAGGCCCATCATATCAAAT
AACTTATTCACTTTTCATGTGGCAGGAAACTGGAATATCGCTTTTAATAAAATGGAAAAATATGCTTCTACATATTTACCACCATAGGCG
TTTTGTTCATATGAGCCTGGTTTGTGCAAAATTAAATCAGAGGCTTCTACAACATGGTTTATTTATGTTGTAGCAAAGTTGGCTCTACAT
AAACATTGTTCTTATTTTAAAATTAACACTATGTGTTCAGTTTTCTTGTGGGCTTCTGAAAGTTGCCATCTTCCCTCCGTGGAGCTCCAT
TTGCTATTTTCATTATACACTATGAGGTAAAATGTAATAACAAAAGAGAGAGAAGTACCACTGTGGCTAGATATATACACACACATATAT
ATATGGATGGATGTAATATATGTAGAACACACACATAGATGTATATAGGATACACACTCATGTATGTAAACGTATACATATGTGTATATA
TGATACATACACATACACACACACGAGAGACAGAAGGAAAGAGAGGAAGAGAGAAGCAAACATGTAGGAAAAAATATAAATCAGCCCCAT
TCTCCCATTCTTTAAGAACAATGATTTTTCTTGATGGAAAATGCATATCACTTGACAGTTGACAAGAAAGTGTCATTTTTGTGTTAGTGT
ATCATATAATTGAATTTGAACAAGATACATATTTTTCTGCATACAAATTTATGAAGCTGGAGTCTACCAAACACAGCTTTAGTCACAAAA
GTTAGTTTAGTTATCTCATTTCGCTTGGAGATGGAATTTCAGGAAGGGATATATTATTTAAGATTATTGTTTAATTACAAGAATTTTAAA
AGAATGTATGAATTCTGTTTTTTAATATAGAAAATAATTATGGAGTTAGGAATCTCATGGCTACATTTACATTTTTAGGTTATTACAGAA
AATTCTCTTAATTTATTATAGTCAAGTGTATTATGTAATCTCTATTTAGAACAGTTTCCCAAAGGAATGTGATTGGATTTACTGGTTGGT
TAATTTCTTGTGAAATATTGTCATAATAGAAGCACAGCTTGAACAAAAGACTGAATTCTGATATAAACTGTCAATATTGCTTTTACCATG
TGTAAGATTTACTTAGTAATCACAGATTTACCTAAAATAAAAGGACCCGGGTTGCAGTGATATTTAGTTAATGATTTGTTTTGGAAAACA
TGCAGTTAGGAGTATTTTTGTATTTTGTCAGATGTTTAGGAGACAGACTTTCGGGTCATGTTTCTTGTCTTGTTCCCAGATCTTTTCTTA
AAAGAACAGTGTGACACCAGAAGCCAAGAGATGGTTTTTACTAACAACAGCTTTGATGAGTTCCTATTAAGGTCGTATTGTGTATTGTGC
CAAATTTTCCACCCAGTATAAATTTAGTAACCCGCTATGAGCATATGTAGGATATTCAATTTGCAGATACTTTTGTTGGTTATGTTGGTT
TATAATAGACAAGTTTTATGGTCATATGCAATTATTCCATTATCTTTTTGGACACAGTGAATATGTTTTTTAGCTAAAAATGTCCTTGGA
AACATAAATGCCTGCCAATAACATGGAATATTGAATTCGGGCAATGTGAATTGATTAATTAGAAAAGGGTCAAAAGAAATACAATGGATG
TGGAAACTAATTCTAAAAAATAGCCCTATTAATAGGGCAGAGACTCTGGTCCATTTCCCAGCTGTACTTCTCTCTAAGAGGTGTATGAAA
AACCCATCTTGCAAAAGAGACCAAAATATTAGACACAATCGTTCCCATTCCTGACTCTTCAATGGAAAAGGAAGGTACAGATGTTTACAG
TGGTGCCCCAGGTGACTCGTTCTCACCACAACAAAAGCAACTAATTGGAAACTAGATGTGTTCAATAATAGATTTCCTCTTTTTTGGCAT
GCTTTTTAGATTTTTTTTCATTTTGTAAAATCTCAGTTAATTTTTCTTTATTGGTATATTTGTGTATGCGAGACAAATCCTGTATTGTAC
AGGATATAAATAGATGCATAAATCCTTAGATACCTGGGTTTTTTAATAGGTTTAGGTTTGGGTATTGTGTTTCTGGTCTTTTAACTCAAA
ATTAAGGTTTGAGCTTTAATAGGACTAAATTATTCACCTGCCTTGGCCTGTGCCTTTATTTTAAATACTGCAATTTTACTTCTTCATTCA
TGTATTTATTATTTTGCTTTTCTTGCTTAAGTATAATTGAAAATATTTGCAGGAACGCACAATTCATTTTATCAAGTTGAATGAATAGGA
CCATTCTCTCCTCATCAGATTTCTGTTCTTTATTTGACTTCATTGACATATACCCTGGTGACTATAACCAGTGAACTGTTCAGAGTCAGT
CTTTTCGGCAAGAACTTCAGAGAACTGTGACACTGGTTATGATGTGATTTTGGGGGGTTTCAGGTACCTAAGCATGATTTTTAAAATCAC
TTCTCTCTTTACATATTTCGAACATATGTTTGCTTTCTACACTTTGCAGATTTTATTTAGGATTTAATTCTTTAAAGACTATATTCATTT
AGTCACTATAGTGGATCTCTTCTACTGCAAGTATTCATCTGATTTTTAAATTATGTAAAATGTAAATCAGCCAAGTATGTCATCCGTTAT
AGTTTCCCCATGCTTTCAGCGCATGGCCATGAGATTTTTACATGTGCATAAGTATTTAGCCAATACACATTTTGCTGACTTCTTTAACCA
TTTATATTGTTTAAATTAGTAATATCCAATGCAGTGCACACTTTTTTGTCTTTTTTCCAACGGAATATTTTGGTTGTCTGTAGCGTTGGA
AGCATTTTATATGATAAAAATAGCAAGAAAAAATTAAAAAGTGTCAACGGTGTGCTGGTTCTAAATTAAGAAGATAGAACAAAGAGAAAG
ACATTAATGTTACCTAAGAAACACATTTAACATCCGAAGAAGCAATGCTGTCCTCACTTGATGTTTCTCTTCTCAACCCAGCAATGGAGA
GCAGGGCTTGCAAAGCCGTACAGAGCCTACGTGCTCTTTCCTGCAAGTGGGAGAAAACTAATCAATGGCACACAGGGCCAGGTGTGGCCC
TGTGAGGCAAAGGATAATGTCACCTCAGGACCAAGGTGGAAACTTACAGCTGAATCCAGGGCTTACTAAGTAGGGAAGTCAGTTTACATA
TTTCAGTTTTCCTCTGATGTTTTTGAGGTACTGTGTATTTGCAGAAGTTTAAGCAGAAGGGTTTTGTTTCTATTGTAAGTTAGGTTCTAA
AAGTGTATAATCTGATACTCTAGCCCAACTGAAATATTATATCTTGGGCGTTACAGCCTTTGTCTTTTTCTTTAGTCACCTTAATACCCA
GTCCTATGCTGTATCTCTGATAGCCTATATAAATGACATATAGGAATATTATTTTCCATATGATCTGTTGTATGGTGTATATGCTATGTG
TTCATTTCGTGTGCAAGTTCAGAGTGTAATAGATTTACCCAGAGAAGGTGTTTCTATACAATGCCCCTACCTATTTGAAATTACATGCTT
GCCCAACACACTGTGAAATAGTTACCAAAATTTGTACAAATGCAGCATCTTCATTCTTTCTGAGAAGACAAGATGGTTTTCTTTACATGA
ACAAATGAACAAAAGAGATCCTAGATCCATAACGTAGCTAAGGCATCTAAGAGTTTGCTGTTGATAATCTTGCTGACCAAAAACTACTGG
AGAGTAACACAGGTTATATGCCATCACAAATACAATGCTCATGAAGAACTGATTTGTAGAGTCAATGAACCTGTGTCCAGAATTTTAATA
GGCTCTCTATTGGAAGGAGAAAGAATTTCAAGTTAACAGTATCTAACTTTATCATAGTTGATGTTAGTAAATTTTAAAAAATGATTTTAT
ATGTATGACAAAAATCTTTGTAAAATGCGCAAGTGCAATAATTTAAAGAGGTCTTAACTTTGCATTTATAAATTATAAATATTGTACATG
TGTGTAATTTTTTCATGTATTCATTTGCAGTCTTTGTATTTAAAAAACATTTACTGTTATGTTTGTATAATAGAACAGTAATCATTTATT
ATAATCTAGGCAAGTTGTAAATAAATTCATAATTCAAACAGCCAGTATATATGCATATATGAGTGTTATATTGCAAAATCTTTGTTTTAC
TTACATGGTTAAAGCAGCAAGAATTCTTTTGTTGATATGTAATTATACACATAAAATATATATATGTATGATACATGAAATATATTTAGA

>73592_73592_2_REV3L-PDE10A_REV3L_chr6_111803952_ENST00000368802_PDE10A_chr6_165832265_ENST00000366882_length(amino acids)=543AA_BP=39
MQTTTWPARCRGWIPANPPSPRPLSRRCRWCESSERPRQIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFSI
EKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCAN
MYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVK
KNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLE
GHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEF
WAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAA

--------------------------------------------------------------
>73592_73592_3_REV3L-PDE10A_REV3L_chr6_111803952_ENST00000368802_PDE10A_chr6_165832265_ENST00000539869_length(transcript)=3952nt_BP=462nt
CATCATCATGGCAACAAGAGCTGCAGCCTGGGACCGAGGAGCCCGTGTGATTCCCGGCGGTGGCGGCAGTGGCGGCAGCACCAGCACCGA
CGAAAGCTCGAGGGCTTCTCTCCTGCGGCCCCTTGCCGGGTGCTCCTGAGGAGGCGGCGGCAGCAGCGCCTACACCGCCCCGCCCGCCGC
TCCTCGAGGTGCCTCTGTGTGAGGGGAGGGGGCCGTGCCGAGAAGGGGAGGGGGCGCCGCCGCCGCTGCGGAGGGAGCCGCCGCCGCTGC
TGCTGCCGCTGCCGGGTCGCCAGTGAAGGGAGGCAGTGGCGGCGGCGGCGAACATGTTTTCAGTAAGGATAGTGACTGCAGACTACTACA
TGGCCAGCCCGCTGCAGGGGCTGGATACCTGCCAATCCCCCCTCACCCAGGCCCCTGTCAAGAAGGTGCCGGTGGTGCGAGTCTTCGGAG
CGACCCCGGCAGATATATGCAAAAAACCTGGTGAATGCCGATCGTTGTGCGCTTTTCCAGGTGGACCATAAGAACAAGGAGTTATATTCA
GACCTTTTTGATATTGGAGAGGAAAAGGAAGGAAAACCTGTCTTCAAGAAGACCAAAGAGATAAGATTTTCAATTGAGAAAGGAATTGCT
GGCCAAGTAGCAAGAACAGGGGAAGTCCTGAACATTCCAGATGCCTATGCAGACCCACGCTTTAACAGAGAAGTAGACTTGTACACAGGC
TACACCACGCGGAACATCCTGTGCATGCCCATCGTCAGCCGAGGCAGCGTGATAGGTGTGGTGCAGATGGTCAACAAAATCAGTGGCAGT
GCCTTCTCTAAAACAGATGAAAACAACTTCAAAATGTTTGCCGTCTTTTGTGCTTTAGCCTTACACTGTGCTAATATGTATCATAGAATT
CGCCACTCAGAGTGCATTTACCGGGTAACGATGGAAAAGCTGTCCTACCATAGCATTTGTACTTCAGAAGAGTGGCAAGGTCTCATGCAA
TTCACCCTTCCCGTGCGTCTCTGCAAAGAAATTGAATTATTCCACTTTGACATTGGTCCTTTTGAAAACATGTGGCCTGGAATTTTTGTC
TACATGGTTCATCGGTCCTGTGGGACATCCTGCTTTGAGCTTGAAAAGTTGTGTCGTTTTATTATGTCTGTGAAGAAGAACTATCGGCGG
GTTCCTTATCACAACTGGAAGCATGCGGTCACTGTAGCACACTGCATGTATGCCATACTTCAGAACAATCACACGCTTTTCACAGACCTT
GAGCGCAAAGGACTGCTGATTGCGTGTCTGTGTCATGACCTGGACCACAGGGGCTTCAGTAACAGCTACCTGCAGAAGTTCGACCACCCT
CTGGCCGCTCTCTACTCCACTTCCACCATGGAGCAGCACCACTTCTCCCAGACTGTGTCCATCCTCCAGTTGGAAGGGCACAATATCTTC
TCCACTCTGAGCTCCAGTGAATATGAGCAGGTGCTTGAGATCATCCGCAAAGCCATCATTGCCACAGACCTTGCTTTATACTTTGGAAAC
AGGAAGCAGTTGGAAGAGATGTACCAGACCGGATCACTAAACCTTAATAATCAATCACATAGAGACCGTGTAATTGGTTTGATGATGACT
GCCTGTGACCTTTGTTCTGTGACAAAACTGTGGCCCGTTACAAAATTGACGGCAAATGATATATATGCAGAATTCTGGGCTGAGGGTGAT
GAAATGAAGAAATTGGGAATACAGCCTATTCCTATGATGGACAGAGACAAGAAGGATGAAGTCCCCCAAGGCCAGCTTGGGTTCTACAAT
GCCGTGGCCATTCCCTGCTATACAACCCTTACCCAGATCCTCCCTCCCACGGAGCCTCTTCTGAAAGCATGCAGGGATAATCTCAGTCAG
TGGGAGAAGGTGATTCGAGGGGAGGAGACTGCAACCTGGATTTCATCCCCATCCGTGGCTCAGAAGGCAGCTGCATCTGAAGATTGAGCA
CTGGTCACCCTGACACGCTGTCCCACCTACAGATCCTCATCTTGCTTCTTTGACATTCTTTTCCTTTTTTTGGGGGGGGTGGGGGGAACC
TGCACCTGGTAACTGGGGTGCAAACCTCTTCAAGAAGGTAACATCAAATAAATAAGTCAAGCAGAGGACTTCCTGCCAATCTCTTCTGTG
AGGCATCATAGACACTGAGCAACCAGGACCACCCCCACGTTCAGAAATCAGCTGGCCAAGTGACTCCATTTGACTTGCAAACCAGCCTTT
TCTAATAGGCTAATATTGCTGAGGCCTTAAAGGAAATGGACAAAAATTATCCAGAAGGGGTACTTTTCCATTGTATCTTTCTAATAAGGG
TTTAAAATGGTACTATTATGGTATTGTACTTGGGCTTTAACATCAATGTTGCTTTGATGTTGTTGGATATAAATAGGAATTTTTACACAT
TACTATTGTGAATGGTGAATGTTCATGTATGACCTACTTGTAATTAACTTGAGTTGTAGTCCACAGCCTCAGGACAAATGTCGTTGAGGT
TACAGAGTAAGAAATGATGGCAAAACGTCAAACTCTTATTTCAGAGCTTCATGAATTTAGTTAGACTAAACATAATTCTTTAAGTTCAAC
CTAAAGGGCTGAGATCAATAAATTTAACACTAGACGAAGTAGACTTCCTGTCTTTTTGAGAAGAGATGAGGTATATGTTACAATAAATCT
CAGAACTTCAAGTAGCAGTTCAAAAGATGTCAGTTTTTAAAATTGTTTTTGTTGTTGTCTTGGCAGTTTTACTGAACCCTTTGCATAAAG
AACAAAATAAAAGCTCGGCATTGTAATTTTTTTAATGGACAAGTCTTATGGATACGAAGGGTACATTTTTCATAATGATTCCTTTATATT
TTCACTTTGTGTCATTGCAGAATTTTAGACTCTCATTCACAATGAAAAGTTTATTTTAAACATTGTTTAATTAAAATACCATACAGTTCT
CTTTTAAACATCAAACCATAAAAAGTGTATTTTGTAATTTTACTCTGACCTGCCGCAGTCACCTCTCACTTATCTCTTCCACGTACTGCA
CGGTCGTATTTCATGAGCTTTCTGTCCATAGCACAGAAACAGAGCAGAAAGTAGTACAATCATGTTGGACCTTCTTTCTGTTCTCTTTAC
TCTTCTCACAGATCAGATCACTCCATAGAAGCCTGTGGGTTTCGATGGTTTCTTCTATACACCTTTTTGGTTGACCAGTATTACTATACA
ATGTAAGTGTTTTAAAAAATACGAAAGTAATACTCTGCACCCCTTCCTACAAAGATGATAAAGCAGTCACTTCTGGCGCATTTTAATAAT
TTAAAGATTTTTAGTGCAATGGCACGGTAACCTCCAAACCTGAATTAGACAGAGACTCACTCAGGAAGTGACAGGCCCATCATATCAAAT
AACTTATTCACTTTTCATGTGGCAGGAAACTGGAATATCGCTTTTAATAAAATGGAAAAATATGCTTCTACATATTTACCACCATAGGCG
TTTTGTTCATATGAGCCTGGTTTGTGCAAAATTAAATCAGAGGCTTCTACAACATGGTTTATTTATGTTGTAGCAAAGTTGGCTCTACAT
AAACATTGTTCTTATTTTAAAATTAACACTATGTGTTCAGTTTTCTTGTGGGCTTCTGAAAGTTGCCATCTTCCCTCCGTGGAGCTCCAT
TTGCTATTTTCATTATACACTATGAGGTAAAATGTAATAACAAAAGAGAGAGAAGTACCACTGTGGCTAGATATATACACACACATATAT
ATATGGATGGATGTAATATATGTAGAACACACACATAGATGTATATAGGATACACACTCATGTATGTAAACGTATACATATGTGTATATA

>73592_73592_3_REV3L-PDE10A_REV3L_chr6_111803952_ENST00000368802_PDE10A_chr6_165832265_ENST00000539869_length(amino acids)=543AA_BP=39
MQTTTWPARCRGWIPANPPSPRPLSRRCRWCESSERPRQIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFSI
EKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCAN
MYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVK
KNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLE
GHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEF
WAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for REV3L-PDE10A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for REV3L-PDE10A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for REV3L-PDE10A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource