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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RFC1-PDS5A (FusionGDB2 ID:73618)

Fusion Gene Summary for RFC1-PDS5A

check button Fusion gene summary
Fusion gene informationFusion gene name: RFC1-PDS5A
Fusion gene ID: 73618
HgeneTgene
Gene symbol

RFC1

PDS5A

Gene ID

6573

23244

Gene namesolute carrier family 19 member 1PDS5 cohesin associated factor A
SynonymsCHMD|FOLT|IFC-1|IFC1|REFC|RFC|RFC1|RFT-1|hRFC|hSLC19A1PIG54|SCC-112|SCC112
Cytomap

21q22.3

4p14

Type of geneprotein-codingprotein-coding
Descriptionreduced folate transporterfolate transporter 1intestinal folate carrier 1placental folate transporterreduced folate carrier 1reduced folate carrier proteinreduced folate transporter 1solute carrier family 19 (folate transporter), member 1sister chromatid cohesion protein PDS5 homolog APDS5, regulator of cohesion maintenance, homolog Acell proliferation-inducing gene 54 proteinsister chromatid cohesion protein 112
Modification date2020031320200327
UniProtAcc.

Q29RF7

Ensembl transtripts involved in fusion geneENST00000349703, ENST00000381897, 
ENST00000418436, 		ENST00000503396, 
ENST00000303538, 
Fusion gene scores* DoF score8 X 7 X 6=33621 X 21 X 8=3528
# samples 926
** MAII scorelog2(9/336*10)=-1.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(26/3528*10)=-3.76226703252907
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RFC1 [Title/Abstract] AND PDS5A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRFC1(39328183)-PDS5A(39827108), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRFC1

GO:0051958

methotrexate transport

22554803

HgeneRFC1

GO:0098838

folate transmembrane transport

22554803

HgeneRFC1

GO:1904447

folate import across plasma membrane

14609557|22554803


check buttonFusion gene breakpoints across RFC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PDS5A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4DLBCTCGA-GS-A9TV-01ARFC1chr4

39328183

-PDS5Achr4

39827108

-
ChimerDB4DLBCTCGA-GS-A9TVRFC1chr4

39328182

-PDS5Achr4

39827108

-
ChimerDB4DLBCTCGA-GS-A9TVRFC1chr4

39328183

-PDS5Achr4

39827108

-


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Fusion Gene ORF analysis for RFC1-PDS5A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000349703ENST00000503396RFC1chr4

39328183

-PDS5Achr4

39827108

-
5CDS-intronENST00000349703ENST00000503396RFC1chr4

39328182

-PDS5Achr4

39827108

-
5CDS-intronENST00000381897ENST00000503396RFC1chr4

39328183

-PDS5Achr4

39827108

-
5CDS-intronENST00000381897ENST00000503396RFC1chr4

39328182

-PDS5Achr4

39827108

-
5UTR-3CDSENST00000418436ENST00000303538RFC1chr4

39328183

-PDS5Achr4

39827108

-
5UTR-3CDSENST00000418436ENST00000303538RFC1chr4

39328182

-PDS5Achr4

39827108

-
5UTR-intronENST00000418436ENST00000503396RFC1chr4

39328183

-PDS5Achr4

39827108

-
5UTR-intronENST00000418436ENST00000503396RFC1chr4

39328182

-PDS5Achr4

39827108

-
In-frameENST00000349703ENST00000303538RFC1chr4

39328183

-PDS5Achr4

39827108

-
In-frameENST00000349703ENST00000303538RFC1chr4

39328182

-PDS5Achr4

39827108

-
In-frameENST00000381897ENST00000303538RFC1chr4

39328183

-PDS5Achr4

39827108

-
In-frameENST00000381897ENST00000303538RFC1chr4

39328182

-PDS5Achr4

39827108

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000349703RFC1chr439328183-ENST00000303538PDS5Achr439827108-3378752110841243
ENST00000381897RFC1chr439328183-ENST00000303538PDS5Achr439827108-3402776134865243
ENST00000349703RFC1chr439328182-ENST00000303538PDS5Achr439827108-3378752110841243
ENST00000381897RFC1chr439328182-ENST00000303538PDS5Achr439827108-3402776134865243

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000349703ENST00000303538RFC1chr439328183-PDS5Achr439827108-0.0002662610.99973375
ENST00000381897ENST00000303538RFC1chr439328183-PDS5Achr439827108-0.0002634520.9997365
ENST00000349703ENST00000303538RFC1chr439328182-PDS5Achr439827108-0.0002662610.99973375
ENST00000381897ENST00000303538RFC1chr439328182-PDS5Achr439827108-0.0002634520.9997365

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Fusion Genomic Features for RFC1-PDS5A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RFC1-PDS5A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:39328183/chr4:39827108)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.PDS5A

Q29RF7

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19907496}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePDS5Achr4:39328182chr4:39827108ENST00000503396016393_4290601.0RepeatHEAT
TgenePDS5Achr4:39328183chr4:39827108ENST00000503396016393_4290601.0RepeatHEAT

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRFC1chr4:39328182chr4:39827108ENST00000349703-625402_4922141148.0DomainBRCT
HgeneRFC1chr4:39328182chr4:39827108ENST00000381897-625402_4922141149.0DomainBRCT
HgeneRFC1chr4:39328183chr4:39827108ENST00000349703-625402_4922141148.0DomainBRCT
HgeneRFC1chr4:39328183chr4:39827108ENST00000381897-625402_4922141149.0DomainBRCT
HgeneRFC1chr4:39328182chr4:39827108ENST00000349703-6251120_11242141148.0MotifNuclear localization signal
HgeneRFC1chr4:39328182chr4:39827108ENST00000381897-6251120_11242141149.0MotifNuclear localization signal
HgeneRFC1chr4:39328183chr4:39827108ENST00000349703-6251120_11242141148.0MotifNuclear localization signal
HgeneRFC1chr4:39328183chr4:39827108ENST00000381897-6251120_11242141149.0MotifNuclear localization signal
HgeneRFC1chr4:39328182chr4:39827108ENST00000349703-625650_6572141148.0Nucleotide bindingATP
HgeneRFC1chr4:39328182chr4:39827108ENST00000381897-625650_6572141149.0Nucleotide bindingATP
HgeneRFC1chr4:39328183chr4:39827108ENST00000349703-625650_6572141148.0Nucleotide bindingATP
HgeneRFC1chr4:39328183chr4:39827108ENST00000381897-625650_6572141149.0Nucleotide bindingATP
TgenePDS5Achr4:39328182chr4:39827108ENST000003035383133393_42913361338.0RepeatHEAT
TgenePDS5Achr4:39328183chr4:39827108ENST000003035383133393_42913361338.0RepeatHEAT


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Fusion Gene Sequence for RFC1-PDS5A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>73618_73618_1_RFC1-PDS5A_RFC1_chr4_39328182_ENST00000349703_PDS5A_chr4_39827108_ENST00000303538_length(transcript)=3378nt_BP=752nt
CTTGCACTTCGCGGGAGAAGTTGTTGGCGCGAATGGATCCTGAGCCTCGATAACAGATTCCTCAACCGGCCCACCCGCCAGCCAGCCAGC
GCCTTCATCCTGGGGCTGCGATGGACATTCGGAAATTCTTTGGAGTAATACCAAGTGGAAAGAAACTTGTAAGTGAAACAGTAAAGAAGA
ATGAGAAAACAAAGTCTGATGAAGAAACTTTAAAAGCAAAGAAAGGAATAAAGGAAATCAAGGTAAATAGCTCCCGTAAAGAGGATGACT
TCAAACAAAAGCAACCAAGCAAGAAAAAGAGGATCATCTATGATTCAGATTCAGAGTCAGAGGAGACGTTGCAGGTAAAAAATGCCAAAA
AGCCACCAGAAAAACTGCCAGTATCTTCTAAACCTGGTAAAATTTCACGGCAGGATCCTGTTACATACATTTCAGAAACAGATGAAGAAG
ATGACTTTATGTGTAAGAAGGCGGCCTCTAAATCAAAAGAGAATGGAAGATCTACAAATAGTCATCTTGGAACATCAAACATGAAAAAGA
ATGAAGAAAACACTAAGACCAAGAATAAGCCTTTATCACCAATAAAACTTACACCCACATCAGTACTTGATTATTTTGGAACTGGAAGTG
TCCAAAGATCTAATAAGAAGATGGTGGCAAGCAAAAGAAAAGAGCTTTCACAAAATACAGATGAGTCTGGATTAAATGATGAAGCCATCG
CCAAGCAATTACAGCTTGATGAAGATGCGGAGGTAAAAATGCATTTGCAAAGGGAGAAAATGAAGGCCAAACAGAAGCAGGCTCCAGCTT
CTGCAAAAACTTGGATTCACAAATGTCCCTGAACAGAAAATGAAGCTCACTTCAGAACACACACTCTCTGCCTTGAAAACTAAAGAGACT
ATTACTTCCTTTTCACATGACCACAAGTCCTCTGATGGAAATGTACAGCAGAAACTCTTGAGAGAGAGGCTAAAAGCAACTCTGTTCTCC
CCCTTCCCCTAGACTTTTCTTACGAAAAGTCAATAATTAAGCAAATTGCTTAACACTTGGTTCCAGTTCCTGCCTATCTGGAGTTTAAAT
GCGTAATACACCATTAATTTCCACGCTGCAGTTTTTATTTTAAAGAAAGTAACAAGATGTCTTTACACTGACACTGAAAATTCATCCATT
TTAGAGCCAGGAATTCCCATGTTACACAGGAAAAAATAGAAGTCTACTGAATTAATTTTTTAAAAGAAAAGAGATCAGATTAAATATTTC
TTTGTTTTTCCTTTTGGAAACTTTTATGTATAATTCTTTCTGCCTGCCTACTTTTCTGCAAAAATGAGATGTACAGATTTCGGTTCCCTG
CTATGAAAAGTGATGTGGTAGCAATTTTATAAATGTTGCTTTCTGATTTTTATCAGAGTGAGAAAATTAAAATTATTGATTTGCAAGTAG
TAAACAGTTCATATTTTGATTTCCCCTCATTTTAGTTTAATATAATTTGCAATAAATGTACATATTGTTGTTTGTTTCATAAAGCATATC
ACTTTAAAATGGTTTTTACTCCTGTGATTATGTTGGAATATTTGGAATTTTAAAGGAGTAAAGACTGTCCAGCATTTGGTTTTATAATGT
TTGTCACCAGATTTTTATTAATGTAAAAAAAATCAATTTTTAAAAAATAGTTGGACTTTGGCAGCTTTTAAGGAAAGTTGGAGGTGTTTT
AGGATTGCTATCAATTTTCAGCATTGTGCTATTTGGAAATAAGTGTTTTGCTTTTGTCTGATGGTCTGGGCTCATTTTTATGTTTATTTT
AGAAAACTGTTGCATCAATATATTATGTTTCTTGGCATTGTTCAGCATAGGTAATGTGTGCACTTTATGTGTACACATAATCATATTTAA
GTTTTTTGCATAAAATAAATGCTTCTAGATGTCATGGCAGTCTTTTTAATCTTTTTATCATATGCTTTCTTGTGAATTTTTTCATGTTAA
AGAGCTAAAGTCATAACATGATTACAGTCAACTCTCCATTATCTATATAAAATAGTGACTAAGCCTCAGGTTTTTAATTTTGTGATAACA
AAATAACGAAGGCATGTAAGACCTGATTCTGGAGGAACATGAAATTTGTCTTTTCTCATGTCCAGAGTTCTATCCTGCCCCCACTGTCCA
CTGTAGGGTCATCCGCAAAGCCCTAGCAGAATGTGCTCACTCCATTTCCTTACACGTTTCTAGCATGGGTCAGAGGAAACAACATTTGTG
TTATAACTTCGTCTTGATAGGCTGTAGTGTACATGGGATGTAAAACAAACAAGTGTATCAAAGGTGGATGATTCTGTTAGAGTGAAGTTT
GAGAGTAAATGTCACTTACGTTTCTCATAGATAATCAAGAGTTGGCTGTGTATTGACTGAAAGATGGGTAATTATTTTAAATATGCATTT
ACACACATTTAGGTATCAGAAGATGCTTAGGGAACAATGGATACCAATGATAGAAAATGATACCTTTACAGGGGCAGAAAAATCCCCACT
CTTCCTTATTGCCTCTTCAGAACCCTTTAGAAAGTATAAAATATTGCCTCCAACATGCTGAAAAAGAGTATCTATGCATAAGTATCAGAG
AAGTCCCTCAAGCAATCAGTAGGTGTGTTCTATTTAGAGAGAGTTTAAAGTTCTCTTAGCATCAGACAACTTGATTCCTAAGGTTTCCAG
TGTGTCACCAACAAAAAGTGCATTGATAGGGACCTTTGTCTCTTCCTCCCTTTGATTAATTGCCCGGCATCACAGTTTACTAGATTACCA
AGTGTTACATCATATTAAATAAAATGTAGCAGAACCATCTGCATCAATATATTCCTGTTTAGATTTTTGCAGGAGAGAAGTTAAAAGGAT
TTGCTCCTTGTATGATGTAAGTGGCCCACCCCAATTTTGTAACATGATGCAAGTGTCTGGCACTAAGGGAAGCAAGAGTAGGGTTGTGGA
AAGACCAAGCTGATGGGGAGGGACTTGTTTACGGGAATTTTTTTAGTTTTCCTTTTCAAAGGAAAACATTAAAATCCCTTAGGAATTTGG
TATTCACATCTCAGAGAACTACAACACAAAAGTGCAGACTTATATTTGAGAATTAATGTTAACCCTTTGTGTCTAGTTTGAAGCTTCTTG
TATTTGTCTAAAACAACAAGCCAGAATTTTGTATCTCCTTTGATAAAAAGTGTGTATAATGTAAAGTAGTTTTGCATATTCTTGTGCTGC
ACATGGGCTGAATTTTTAAATTTTTTTTAAAAACTTGAAGCAGAACCTTGTAATTTGTGTAAATGACAAGTGTAAAATCCTACCATAAAA

>73618_73618_1_RFC1-PDS5A_RFC1_chr4_39328182_ENST00000349703_PDS5A_chr4_39827108_ENST00000303538_length(amino acids)=243AA_BP=214
MDIRKFFGVIPSGKKLVSETVKKNEKTKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPSKKKRIIYDSDSESEETLQVKNAKKPPEKLP
VSSKPGKISRQDPVTYISETDEEDDFMCKKAASKSKENGRSTNSHLGTSNMKKNEENTKTKNKPLSPIKLTPTSVLDYFGTGSVQRSNKK

--------------------------------------------------------------
>73618_73618_2_RFC1-PDS5A_RFC1_chr4_39328182_ENST00000381897_PDS5A_chr4_39827108_ENST00000303538_length(transcript)=3402nt_BP=776nt
ACCGCGCGCCACTGTCTTCGCCTTCTTGCACTTCGCGGGAGAAGTTGTTGGCGCGAATGGATCCTGAGCCTCGATAACAGATTCCTCAAC
CGGCCCACCCGCCAGCCAGCCAGCGCCTTCATCCTGGGGCTGCGATGGACATTCGGAAATTCTTTGGAGTAATACCAAGTGGAAAGAAAC
TTGTAAGTGAAACAGTAAAGAAGAATGAGAAAACAAAGTCTGATGAAGAAACTTTAAAAGCAAAGAAAGGAATAAAGGAAATCAAGGTAA
ATAGCTCCCGTAAAGAGGATGACTTCAAACAAAAGCAACCAAGCAAGAAAAAGAGGATCATCTATGATTCAGATTCAGAGTCAGAGGAGA
CGTTGCAGGTAAAAAATGCCAAAAAGCCACCAGAAAAACTGCCAGTATCTTCTAAACCTGGTAAAATTTCACGGCAGGATCCTGTTACAT
ACATTTCAGAAACAGATGAAGAAGATGACTTTATGTGTAAGAAGGCGGCCTCTAAATCAAAAGAGAATGGAAGATCTACAAATAGTCATC
TTGGAACATCAAACATGAAAAAGAATGAAGAAAACACTAAGACCAAGAATAAGCCTTTATCACCAATAAAACTTACACCCACATCAGTAC
TTGATTATTTTGGAACTGGAAGTGTCCAAAGATCTAATAAGAAGATGGTGGCAAGCAAAAGAAAAGAGCTTTCACAAAATACAGATGAGT
CTGGATTAAATGATGAAGCCATCGCCAAGCAATTACAGCTTGATGAAGATGCGGAGGTAAAAATGCATTTGCAAAGGGAGAAAATGAAGG
CCAAACAGAAGCAGGCTCCAGCTTCTGCAAAAACTTGGATTCACAAATGTCCCTGAACAGAAAATGAAGCTCACTTCAGAACACACACTC
TCTGCCTTGAAAACTAAAGAGACTATTACTTCCTTTTCACATGACCACAAGTCCTCTGATGGAAATGTACAGCAGAAACTCTTGAGAGAG
AGGCTAAAAGCAACTCTGTTCTCCCCCTTCCCCTAGACTTTTCTTACGAAAAGTCAATAATTAAGCAAATTGCTTAACACTTGGTTCCAG
TTCCTGCCTATCTGGAGTTTAAATGCGTAATACACCATTAATTTCCACGCTGCAGTTTTTATTTTAAAGAAAGTAACAAGATGTCTTTAC
ACTGACACTGAAAATTCATCCATTTTAGAGCCAGGAATTCCCATGTTACACAGGAAAAAATAGAAGTCTACTGAATTAATTTTTTAAAAG
AAAAGAGATCAGATTAAATATTTCTTTGTTTTTCCTTTTGGAAACTTTTATGTATAATTCTTTCTGCCTGCCTACTTTTCTGCAAAAATG
AGATGTACAGATTTCGGTTCCCTGCTATGAAAAGTGATGTGGTAGCAATTTTATAAATGTTGCTTTCTGATTTTTATCAGAGTGAGAAAA
TTAAAATTATTGATTTGCAAGTAGTAAACAGTTCATATTTTGATTTCCCCTCATTTTAGTTTAATATAATTTGCAATAAATGTACATATT
GTTGTTTGTTTCATAAAGCATATCACTTTAAAATGGTTTTTACTCCTGTGATTATGTTGGAATATTTGGAATTTTAAAGGAGTAAAGACT
GTCCAGCATTTGGTTTTATAATGTTTGTCACCAGATTTTTATTAATGTAAAAAAAATCAATTTTTAAAAAATAGTTGGACTTTGGCAGCT
TTTAAGGAAAGTTGGAGGTGTTTTAGGATTGCTATCAATTTTCAGCATTGTGCTATTTGGAAATAAGTGTTTTGCTTTTGTCTGATGGTC
TGGGCTCATTTTTATGTTTATTTTAGAAAACTGTTGCATCAATATATTATGTTTCTTGGCATTGTTCAGCATAGGTAATGTGTGCACTTT
ATGTGTACACATAATCATATTTAAGTTTTTTGCATAAAATAAATGCTTCTAGATGTCATGGCAGTCTTTTTAATCTTTTTATCATATGCT
TTCTTGTGAATTTTTTCATGTTAAAGAGCTAAAGTCATAACATGATTACAGTCAACTCTCCATTATCTATATAAAATAGTGACTAAGCCT
CAGGTTTTTAATTTTGTGATAACAAAATAACGAAGGCATGTAAGACCTGATTCTGGAGGAACATGAAATTTGTCTTTTCTCATGTCCAGA
GTTCTATCCTGCCCCCACTGTCCACTGTAGGGTCATCCGCAAAGCCCTAGCAGAATGTGCTCACTCCATTTCCTTACACGTTTCTAGCAT
GGGTCAGAGGAAACAACATTTGTGTTATAACTTCGTCTTGATAGGCTGTAGTGTACATGGGATGTAAAACAAACAAGTGTATCAAAGGTG
GATGATTCTGTTAGAGTGAAGTTTGAGAGTAAATGTCACTTACGTTTCTCATAGATAATCAAGAGTTGGCTGTGTATTGACTGAAAGATG
GGTAATTATTTTAAATATGCATTTACACACATTTAGGTATCAGAAGATGCTTAGGGAACAATGGATACCAATGATAGAAAATGATACCTT
TACAGGGGCAGAAAAATCCCCACTCTTCCTTATTGCCTCTTCAGAACCCTTTAGAAAGTATAAAATATTGCCTCCAACATGCTGAAAAAG
AGTATCTATGCATAAGTATCAGAGAAGTCCCTCAAGCAATCAGTAGGTGTGTTCTATTTAGAGAGAGTTTAAAGTTCTCTTAGCATCAGA
CAACTTGATTCCTAAGGTTTCCAGTGTGTCACCAACAAAAAGTGCATTGATAGGGACCTTTGTCTCTTCCTCCCTTTGATTAATTGCCCG
GCATCACAGTTTACTAGATTACCAAGTGTTACATCATATTAAATAAAATGTAGCAGAACCATCTGCATCAATATATTCCTGTTTAGATTT
TTGCAGGAGAGAAGTTAAAAGGATTTGCTCCTTGTATGATGTAAGTGGCCCACCCCAATTTTGTAACATGATGCAAGTGTCTGGCACTAA
GGGAAGCAAGAGTAGGGTTGTGGAAAGACCAAGCTGATGGGGAGGGACTTGTTTACGGGAATTTTTTTAGTTTTCCTTTTCAAAGGAAAA
CATTAAAATCCCTTAGGAATTTGGTATTCACATCTCAGAGAACTACAACACAAAAGTGCAGACTTATATTTGAGAATTAATGTTAACCCT
TTGTGTCTAGTTTGAAGCTTCTTGTATTTGTCTAAAACAACAAGCCAGAATTTTGTATCTCCTTTGATAAAAAGTGTGTATAATGTAAAG
TAGTTTTGCATATTCTTGTGCTGCACATGGGCTGAATTTTTAAATTTTTTTTAAAAACTTGAAGCAGAACCTTGTAATTTGTGTAAATGA

>73618_73618_2_RFC1-PDS5A_RFC1_chr4_39328182_ENST00000381897_PDS5A_chr4_39827108_ENST00000303538_length(amino acids)=243AA_BP=214
MDIRKFFGVIPSGKKLVSETVKKNEKTKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPSKKKRIIYDSDSESEETLQVKNAKKPPEKLP
VSSKPGKISRQDPVTYISETDEEDDFMCKKAASKSKENGRSTNSHLGTSNMKKNEENTKTKNKPLSPIKLTPTSVLDYFGTGSVQRSNKK

--------------------------------------------------------------
>73618_73618_3_RFC1-PDS5A_RFC1_chr4_39328183_ENST00000349703_PDS5A_chr4_39827108_ENST00000303538_length(transcript)=3378nt_BP=752nt
CTTGCACTTCGCGGGAGAAGTTGTTGGCGCGAATGGATCCTGAGCCTCGATAACAGATTCCTCAACCGGCCCACCCGCCAGCCAGCCAGC
GCCTTCATCCTGGGGCTGCGATGGACATTCGGAAATTCTTTGGAGTAATACCAAGTGGAAAGAAACTTGTAAGTGAAACAGTAAAGAAGA
ATGAGAAAACAAAGTCTGATGAAGAAACTTTAAAAGCAAAGAAAGGAATAAAGGAAATCAAGGTAAATAGCTCCCGTAAAGAGGATGACT
TCAAACAAAAGCAACCAAGCAAGAAAAAGAGGATCATCTATGATTCAGATTCAGAGTCAGAGGAGACGTTGCAGGTAAAAAATGCCAAAA
AGCCACCAGAAAAACTGCCAGTATCTTCTAAACCTGGTAAAATTTCACGGCAGGATCCTGTTACATACATTTCAGAAACAGATGAAGAAG
ATGACTTTATGTGTAAGAAGGCGGCCTCTAAATCAAAAGAGAATGGAAGATCTACAAATAGTCATCTTGGAACATCAAACATGAAAAAGA
ATGAAGAAAACACTAAGACCAAGAATAAGCCTTTATCACCAATAAAACTTACACCCACATCAGTACTTGATTATTTTGGAACTGGAAGTG
TCCAAAGATCTAATAAGAAGATGGTGGCAAGCAAAAGAAAAGAGCTTTCACAAAATACAGATGAGTCTGGATTAAATGATGAAGCCATCG
CCAAGCAATTACAGCTTGATGAAGATGCGGAGGTAAAAATGCATTTGCAAAGGGAGAAAATGAAGGCCAAACAGAAGCAGGCTCCAGCTT
CTGCAAAAACTTGGATTCACAAATGTCCCTGAACAGAAAATGAAGCTCACTTCAGAACACACACTCTCTGCCTTGAAAACTAAAGAGACT
ATTACTTCCTTTTCACATGACCACAAGTCCTCTGATGGAAATGTACAGCAGAAACTCTTGAGAGAGAGGCTAAAAGCAACTCTGTTCTCC
CCCTTCCCCTAGACTTTTCTTACGAAAAGTCAATAATTAAGCAAATTGCTTAACACTTGGTTCCAGTTCCTGCCTATCTGGAGTTTAAAT
GCGTAATACACCATTAATTTCCACGCTGCAGTTTTTATTTTAAAGAAAGTAACAAGATGTCTTTACACTGACACTGAAAATTCATCCATT
TTAGAGCCAGGAATTCCCATGTTACACAGGAAAAAATAGAAGTCTACTGAATTAATTTTTTAAAAGAAAAGAGATCAGATTAAATATTTC
TTTGTTTTTCCTTTTGGAAACTTTTATGTATAATTCTTTCTGCCTGCCTACTTTTCTGCAAAAATGAGATGTACAGATTTCGGTTCCCTG
CTATGAAAAGTGATGTGGTAGCAATTTTATAAATGTTGCTTTCTGATTTTTATCAGAGTGAGAAAATTAAAATTATTGATTTGCAAGTAG
TAAACAGTTCATATTTTGATTTCCCCTCATTTTAGTTTAATATAATTTGCAATAAATGTACATATTGTTGTTTGTTTCATAAAGCATATC
ACTTTAAAATGGTTTTTACTCCTGTGATTATGTTGGAATATTTGGAATTTTAAAGGAGTAAAGACTGTCCAGCATTTGGTTTTATAATGT
TTGTCACCAGATTTTTATTAATGTAAAAAAAATCAATTTTTAAAAAATAGTTGGACTTTGGCAGCTTTTAAGGAAAGTTGGAGGTGTTTT
AGGATTGCTATCAATTTTCAGCATTGTGCTATTTGGAAATAAGTGTTTTGCTTTTGTCTGATGGTCTGGGCTCATTTTTATGTTTATTTT
AGAAAACTGTTGCATCAATATATTATGTTTCTTGGCATTGTTCAGCATAGGTAATGTGTGCACTTTATGTGTACACATAATCATATTTAA
GTTTTTTGCATAAAATAAATGCTTCTAGATGTCATGGCAGTCTTTTTAATCTTTTTATCATATGCTTTCTTGTGAATTTTTTCATGTTAA
AGAGCTAAAGTCATAACATGATTACAGTCAACTCTCCATTATCTATATAAAATAGTGACTAAGCCTCAGGTTTTTAATTTTGTGATAACA
AAATAACGAAGGCATGTAAGACCTGATTCTGGAGGAACATGAAATTTGTCTTTTCTCATGTCCAGAGTTCTATCCTGCCCCCACTGTCCA
CTGTAGGGTCATCCGCAAAGCCCTAGCAGAATGTGCTCACTCCATTTCCTTACACGTTTCTAGCATGGGTCAGAGGAAACAACATTTGTG
TTATAACTTCGTCTTGATAGGCTGTAGTGTACATGGGATGTAAAACAAACAAGTGTATCAAAGGTGGATGATTCTGTTAGAGTGAAGTTT
GAGAGTAAATGTCACTTACGTTTCTCATAGATAATCAAGAGTTGGCTGTGTATTGACTGAAAGATGGGTAATTATTTTAAATATGCATTT
ACACACATTTAGGTATCAGAAGATGCTTAGGGAACAATGGATACCAATGATAGAAAATGATACCTTTACAGGGGCAGAAAAATCCCCACT
CTTCCTTATTGCCTCTTCAGAACCCTTTAGAAAGTATAAAATATTGCCTCCAACATGCTGAAAAAGAGTATCTATGCATAAGTATCAGAG
AAGTCCCTCAAGCAATCAGTAGGTGTGTTCTATTTAGAGAGAGTTTAAAGTTCTCTTAGCATCAGACAACTTGATTCCTAAGGTTTCCAG
TGTGTCACCAACAAAAAGTGCATTGATAGGGACCTTTGTCTCTTCCTCCCTTTGATTAATTGCCCGGCATCACAGTTTACTAGATTACCA
AGTGTTACATCATATTAAATAAAATGTAGCAGAACCATCTGCATCAATATATTCCTGTTTAGATTTTTGCAGGAGAGAAGTTAAAAGGAT
TTGCTCCTTGTATGATGTAAGTGGCCCACCCCAATTTTGTAACATGATGCAAGTGTCTGGCACTAAGGGAAGCAAGAGTAGGGTTGTGGA
AAGACCAAGCTGATGGGGAGGGACTTGTTTACGGGAATTTTTTTAGTTTTCCTTTTCAAAGGAAAACATTAAAATCCCTTAGGAATTTGG
TATTCACATCTCAGAGAACTACAACACAAAAGTGCAGACTTATATTTGAGAATTAATGTTAACCCTTTGTGTCTAGTTTGAAGCTTCTTG
TATTTGTCTAAAACAACAAGCCAGAATTTTGTATCTCCTTTGATAAAAAGTGTGTATAATGTAAAGTAGTTTTGCATATTCTTGTGCTGC
ACATGGGCTGAATTTTTAAATTTTTTTTAAAAACTTGAAGCAGAACCTTGTAATTTGTGTAAATGACAAGTGTAAAATCCTACCATAAAA

>73618_73618_3_RFC1-PDS5A_RFC1_chr4_39328183_ENST00000349703_PDS5A_chr4_39827108_ENST00000303538_length(amino acids)=243AA_BP=214
MDIRKFFGVIPSGKKLVSETVKKNEKTKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPSKKKRIIYDSDSESEETLQVKNAKKPPEKLP
VSSKPGKISRQDPVTYISETDEEDDFMCKKAASKSKENGRSTNSHLGTSNMKKNEENTKTKNKPLSPIKLTPTSVLDYFGTGSVQRSNKK

--------------------------------------------------------------
>73618_73618_4_RFC1-PDS5A_RFC1_chr4_39328183_ENST00000381897_PDS5A_chr4_39827108_ENST00000303538_length(transcript)=3402nt_BP=776nt
ACCGCGCGCCACTGTCTTCGCCTTCTTGCACTTCGCGGGAGAAGTTGTTGGCGCGAATGGATCCTGAGCCTCGATAACAGATTCCTCAAC
CGGCCCACCCGCCAGCCAGCCAGCGCCTTCATCCTGGGGCTGCGATGGACATTCGGAAATTCTTTGGAGTAATACCAAGTGGAAAGAAAC
TTGTAAGTGAAACAGTAAAGAAGAATGAGAAAACAAAGTCTGATGAAGAAACTTTAAAAGCAAAGAAAGGAATAAAGGAAATCAAGGTAA
ATAGCTCCCGTAAAGAGGATGACTTCAAACAAAAGCAACCAAGCAAGAAAAAGAGGATCATCTATGATTCAGATTCAGAGTCAGAGGAGA
CGTTGCAGGTAAAAAATGCCAAAAAGCCACCAGAAAAACTGCCAGTATCTTCTAAACCTGGTAAAATTTCACGGCAGGATCCTGTTACAT
ACATTTCAGAAACAGATGAAGAAGATGACTTTATGTGTAAGAAGGCGGCCTCTAAATCAAAAGAGAATGGAAGATCTACAAATAGTCATC
TTGGAACATCAAACATGAAAAAGAATGAAGAAAACACTAAGACCAAGAATAAGCCTTTATCACCAATAAAACTTACACCCACATCAGTAC
TTGATTATTTTGGAACTGGAAGTGTCCAAAGATCTAATAAGAAGATGGTGGCAAGCAAAAGAAAAGAGCTTTCACAAAATACAGATGAGT
CTGGATTAAATGATGAAGCCATCGCCAAGCAATTACAGCTTGATGAAGATGCGGAGGTAAAAATGCATTTGCAAAGGGAGAAAATGAAGG
CCAAACAGAAGCAGGCTCCAGCTTCTGCAAAAACTTGGATTCACAAATGTCCCTGAACAGAAAATGAAGCTCACTTCAGAACACACACTC
TCTGCCTTGAAAACTAAAGAGACTATTACTTCCTTTTCACATGACCACAAGTCCTCTGATGGAAATGTACAGCAGAAACTCTTGAGAGAG
AGGCTAAAAGCAACTCTGTTCTCCCCCTTCCCCTAGACTTTTCTTACGAAAAGTCAATAATTAAGCAAATTGCTTAACACTTGGTTCCAG
TTCCTGCCTATCTGGAGTTTAAATGCGTAATACACCATTAATTTCCACGCTGCAGTTTTTATTTTAAAGAAAGTAACAAGATGTCTTTAC
ACTGACACTGAAAATTCATCCATTTTAGAGCCAGGAATTCCCATGTTACACAGGAAAAAATAGAAGTCTACTGAATTAATTTTTTAAAAG
AAAAGAGATCAGATTAAATATTTCTTTGTTTTTCCTTTTGGAAACTTTTATGTATAATTCTTTCTGCCTGCCTACTTTTCTGCAAAAATG
AGATGTACAGATTTCGGTTCCCTGCTATGAAAAGTGATGTGGTAGCAATTTTATAAATGTTGCTTTCTGATTTTTATCAGAGTGAGAAAA
TTAAAATTATTGATTTGCAAGTAGTAAACAGTTCATATTTTGATTTCCCCTCATTTTAGTTTAATATAATTTGCAATAAATGTACATATT
GTTGTTTGTTTCATAAAGCATATCACTTTAAAATGGTTTTTACTCCTGTGATTATGTTGGAATATTTGGAATTTTAAAGGAGTAAAGACT
GTCCAGCATTTGGTTTTATAATGTTTGTCACCAGATTTTTATTAATGTAAAAAAAATCAATTTTTAAAAAATAGTTGGACTTTGGCAGCT
TTTAAGGAAAGTTGGAGGTGTTTTAGGATTGCTATCAATTTTCAGCATTGTGCTATTTGGAAATAAGTGTTTTGCTTTTGTCTGATGGTC
TGGGCTCATTTTTATGTTTATTTTAGAAAACTGTTGCATCAATATATTATGTTTCTTGGCATTGTTCAGCATAGGTAATGTGTGCACTTT
ATGTGTACACATAATCATATTTAAGTTTTTTGCATAAAATAAATGCTTCTAGATGTCATGGCAGTCTTTTTAATCTTTTTATCATATGCT
TTCTTGTGAATTTTTTCATGTTAAAGAGCTAAAGTCATAACATGATTACAGTCAACTCTCCATTATCTATATAAAATAGTGACTAAGCCT
CAGGTTTTTAATTTTGTGATAACAAAATAACGAAGGCATGTAAGACCTGATTCTGGAGGAACATGAAATTTGTCTTTTCTCATGTCCAGA
GTTCTATCCTGCCCCCACTGTCCACTGTAGGGTCATCCGCAAAGCCCTAGCAGAATGTGCTCACTCCATTTCCTTACACGTTTCTAGCAT
GGGTCAGAGGAAACAACATTTGTGTTATAACTTCGTCTTGATAGGCTGTAGTGTACATGGGATGTAAAACAAACAAGTGTATCAAAGGTG
GATGATTCTGTTAGAGTGAAGTTTGAGAGTAAATGTCACTTACGTTTCTCATAGATAATCAAGAGTTGGCTGTGTATTGACTGAAAGATG
GGTAATTATTTTAAATATGCATTTACACACATTTAGGTATCAGAAGATGCTTAGGGAACAATGGATACCAATGATAGAAAATGATACCTT
TACAGGGGCAGAAAAATCCCCACTCTTCCTTATTGCCTCTTCAGAACCCTTTAGAAAGTATAAAATATTGCCTCCAACATGCTGAAAAAG
AGTATCTATGCATAAGTATCAGAGAAGTCCCTCAAGCAATCAGTAGGTGTGTTCTATTTAGAGAGAGTTTAAAGTTCTCTTAGCATCAGA
CAACTTGATTCCTAAGGTTTCCAGTGTGTCACCAACAAAAAGTGCATTGATAGGGACCTTTGTCTCTTCCTCCCTTTGATTAATTGCCCG
GCATCACAGTTTACTAGATTACCAAGTGTTACATCATATTAAATAAAATGTAGCAGAACCATCTGCATCAATATATTCCTGTTTAGATTT
TTGCAGGAGAGAAGTTAAAAGGATTTGCTCCTTGTATGATGTAAGTGGCCCACCCCAATTTTGTAACATGATGCAAGTGTCTGGCACTAA
GGGAAGCAAGAGTAGGGTTGTGGAAAGACCAAGCTGATGGGGAGGGACTTGTTTACGGGAATTTTTTTAGTTTTCCTTTTCAAAGGAAAA
CATTAAAATCCCTTAGGAATTTGGTATTCACATCTCAGAGAACTACAACACAAAAGTGCAGACTTATATTTGAGAATTAATGTTAACCCT
TTGTGTCTAGTTTGAAGCTTCTTGTATTTGTCTAAAACAACAAGCCAGAATTTTGTATCTCCTTTGATAAAAAGTGTGTATAATGTAAAG
TAGTTTTGCATATTCTTGTGCTGCACATGGGCTGAATTTTTAAATTTTTTTTAAAAACTTGAAGCAGAACCTTGTAATTTGTGTAAATGA

>73618_73618_4_RFC1-PDS5A_RFC1_chr4_39328183_ENST00000381897_PDS5A_chr4_39827108_ENST00000303538_length(amino acids)=243AA_BP=214
MDIRKFFGVIPSGKKLVSETVKKNEKTKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPSKKKRIIYDSDSESEETLQVKNAKKPPEKLP
VSSKPGKISRQDPVTYISETDEEDDFMCKKAASKSKENGRSTNSHLGTSNMKKNEENTKTKNKPLSPIKLTPTSVLDYFGTGSVQRSNKK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RFC1-PDS5A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RFC1-PDS5A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RFC1-PDS5A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource