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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:RFWD2-FBXO28 (FusionGDB2 ID:73670)

Fusion Gene Summary for RFWD2-FBXO28

Fusion gene summary

Fusion gene information	Fusion gene name: RFWD2-FBXO28
	Fusion gene ID: 73670
		Hgene	Tgene
	Gene symbol	RFWD2	FBXO28
	Gene ID	64326	23219
	Gene name	COP1 E3 ubiquitin ligase	F-box protein 28
	Synonyms	CFAP78\|FAP78\|RFWD2\|RNF200	CENP-30\|Fbx28
	Cytomap	1q25.1-q25.2	1q42.11
	Type of gene	protein-coding	protein-coding
	Description	E3 ubiquitin-protein ligase COP1E3 ubiquitin-protein ligase RFWD2RING finger protein 200RING-type E3 ubiquitin transferase RFWD2constitutive photomorphogenesis protein 1 homologconstitutive photomorphogenic protein 1putative ubiquitin ligase COP1ri	F-box only protein 28centromere protein 30
	Modification date	20200313	20200313
	UniProtAcc	.	Q9NVF7
	Ensembl transtripts involved in fusion gene	ENST00000308769, ENST00000367669,	ENST00000366862, ENST00000424254,
Fusion gene scores	* DoF score	17 X 15 X 10=2550	2 X 4 X 2=16
	# samples	20	3
	** MAII score	log2(20/2550*10)=-3.6724253419715 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/16*10)=0.906890595608518 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: RFWD2 [Title/Abstract] AND FBXO28 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	RFWD2(176118141)-FBXO28(224318173), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RFWD2	GO:0010212	response to ionizing radiation	19805145

Fusion gene breakpoints across RFWD2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across FBXO28 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	UCEC	TCGA-PG-A5BC	RFWD2	chr1	176118141	-	FBXO28	chr1	224318173	+

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Fusion Gene ORF analysis for RFWD2-FBXO28

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000308769	ENST00000366862	RFWD2	chr1	176118141	-	FBXO28	chr1	224318173	+
In-frame	ENST00000308769	ENST00000424254	RFWD2	chr1	176118141	-	FBXO28	chr1	224318173	+
In-frame	ENST00000367669	ENST00000366862	RFWD2	chr1	176118141	-	FBXO28	chr1	224318173	+
In-frame	ENST00000367669	ENST00000424254	RFWD2	chr1	176118141	-	FBXO28	chr1	224318173	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000367669	RFWD2	chr1	176118141	-	ENST00000366862	FBXO28	chr1	224318173	+	6487	1346	515	2185	556
ENST00000367669	RFWD2	chr1	176118141	-	ENST00000424254	FBXO28	chr1	224318173	+	2394	1346	515	1618	367
ENST00000308769	RFWD2	chr1	176118141	-	ENST00000366862	FBXO28	chr1	224318173	+	5960	819	0	1658	552
ENST00000308769	RFWD2	chr1	176118141	-	ENST00000424254	FBXO28	chr1	224318173	+	1867	819	0	1091	363

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000367669	ENST00000366862	RFWD2	chr1	176118141	-	FBXO28	chr1	224318173	+	0.000204907	0.99979514
ENST00000367669	ENST00000424254	RFWD2	chr1	176118141	-	FBXO28	chr1	224318173	+	0.003908418	0.99609154
ENST00000308769	ENST00000366862	RFWD2	chr1	176118141	-	FBXO28	chr1	224318173	+	0.000218582	0.9997814
ENST00000308769	ENST00000424254	RFWD2	chr1	176118141	-	FBXO28	chr1	224318173	+	0.003419001	0.996581

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Fusion Genomic Features for RFWD2-FBXO28

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
RFWD2	chr1	176118141	-	FBXO28	chr1	224318173	+	4.74E-10	1
RFWD2	chr1	176118141	-	FBXO28	chr1	224318173	+	4.74E-10	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RFWD2-FBXO28

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:176118141/chr1:224318173)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	FBXO28 Q9NVF7
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RFWD2

chr1:176118141

chr1:224318173

ENST00000308769

2_110

273

708.0

Compositional bias

Note=Ser-rich

Hgene

RFWD2

chr1:176118141

chr1:224318173

ENST00000367669

2_110

277

732.0

Compositional bias

Note=Ser-rich

Hgene

RFWD2

chr1:176118141

chr1:224318173

ENST00000308769

109_113

273

708.0

Motif

Note=Nuclear localization signal 1

Hgene

RFWD2

chr1:176118141

chr1:224318173

ENST00000308769

195_206

273

708.0

Motif

Note=Nuclear localization signal 2

Hgene

RFWD2

chr1:176118141

chr1:224318173

ENST00000308769

235_245

273

708.0

Motif

Nuclear export signal

Hgene

RFWD2

chr1:176118141

chr1:224318173

ENST00000367669

109_113

277

732.0

Motif

Note=Nuclear localization signal 1

Hgene

RFWD2

chr1:176118141

chr1:224318173

ENST00000367669

195_206

277

732.0

Motif

Note=Nuclear localization signal 2

Hgene

RFWD2

chr1:176118141

chr1:224318173

ENST00000367669

235_245

277

732.0

Motif

Nuclear export signal

Hgene

RFWD2

chr1:176118141

chr1:224318173

ENST00000308769

136_174

273

708.0

Zinc finger

RING-type

Hgene

RFWD2

chr1:176118141

chr1:224318173

ENST00000367669

136_174

277

732.0

Zinc finger

RING-type

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RFWD2

chr1:176118141

chr1:224318173

ENST00000308769

233_301

273

708.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

RFWD2

chr1:176118141

chr1:224318173

ENST00000367669

233_301

277

732.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

RFWD2

chr1:176118141

chr1:224318173

ENST00000308769

419_458

273

708.0

Repeat

Note=WD 1

Hgene

RFWD2

chr1:176118141

chr1:224318173

ENST00000308769

468_508

273

708.0

Repeat

Note=WD 2

Hgene

RFWD2

chr1:176118141

chr1:224318173

ENST00000308769

511_551

273

708.0

Repeat

Note=WD 3

Hgene

RFWD2

chr1:176118141

chr1:224318173

ENST00000308769

553_593

273

708.0

Repeat

Note=WD 4

Hgene

RFWD2

chr1:176118141

chr1:224318173

ENST00000308769

597_635

273

708.0

Repeat

Note=WD 5

Hgene

RFWD2

chr1:176118141

chr1:224318173

ENST00000308769

638_677

273

708.0

Repeat

Note=WD 6

Hgene

RFWD2

chr1:176118141

chr1:224318173

ENST00000308769

691_729

273

708.0

Repeat

Note=WD 7

Hgene

RFWD2

chr1:176118141

chr1:224318173

ENST00000367669

419_458

277

732.0

Repeat

Note=WD 1

Hgene

RFWD2

chr1:176118141

chr1:224318173

ENST00000367669

468_508

277

732.0

Repeat

Note=WD 2

Hgene

RFWD2

chr1:176118141

chr1:224318173

ENST00000367669

511_551

277

732.0

Repeat

Note=WD 3

Hgene

RFWD2

chr1:176118141

chr1:224318173

ENST00000367669

553_593

277

732.0

Repeat

Note=WD 4

Hgene

RFWD2

chr1:176118141

chr1:224318173

ENST00000367669

597_635

277

732.0

Repeat

Note=WD 5

Hgene

RFWD2

chr1:176118141

chr1:224318173

ENST00000367669

638_677

277

732.0

Repeat

Note=WD 6

Hgene

RFWD2

chr1:176118141

chr1:224318173

ENST00000367669

691_729

277

732.0

Repeat

Note=WD 7

Tgene

FBXO28

chr1:176118141

chr1:224318173

ENST00000366862

61_109

369.0

Domain

F-box

Tgene

FBXO28

chr1:176118141

chr1:224318173

ENST00000424254

61_109

180.0

Domain

F-box

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Fusion Gene Sequence for RFWD2-FBXO28

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>73670_73670_1_RFWD2-FBXO28_RFWD2_chr1_176118141_ENST00000308769_FBXO28_chr1_224318173_ENST00000366862_length(transcript)=5960nt_BP=819nt
ATGTCTGGTAGCCGCCAGGCCGGGTCGGGCTCCGCTGGGACAAGCCCCGGGTCCTCGGCGGCCTCCTCGGTGACTTCCGCCTCCTCGTCT
TTATCCTCTTCCCCGTCGCCGCCTTCCGTGGCGGTTTCGGCGGCAGCGCTGGTGTCCGGCGGGGTGGCCCAGGCCGCCGGCTCGGGCGGC
CTCGGGGGCCCGGTGCGGCCTGTGTTGGTGGCGCCCGCCGTATCGGGTAGCGGCGGCGGGGCGGTGTCCACGGGCCTGTCCCGGCACAGC
TGCGCGGCCAGGCCCAGCGCCGGCGTAGGAGGCAGCAGCTCCAGCCTAGGCAGCGGCAGCAGGAAGCGACCTCTCCTCGCCCCCCTCTGC
AACGGGCTCATCAACTCCTACGAGGACAAAAGCAACGACTTCGTATGCCCCATCTGCTTTGATATGATTGAAGAAGCATACATGACAAAA
TGTGGCCACAGCTTTTGCTACAAGTGTATTCATCAGAGTTTGGAGGACAATAATAGATGTCCCAAGTGTAACTATGTTGTGGACAATATT
GACCATCTGTATCCTAATTTCTTGGTGAATGAACTCATTCTTAAACAGAAGCAAAGATTTGAGGAAAAGAGGTTCAAATTGGACCACTCA
AATGGCCACAGGTGGCAGATATTTCAAGATTGGTTGGGAACTGACCAAGATAACCTTGATTTGGCCAATGTCAATCTTATGTTGGAGTTA
CTAGTGCAGAAGAAGAAACAACTGGAAGCAGAATCACATGCAGCCCAACTACAGATTCTTATGGAATTCCTCAAGGTTGCAAGAAGAAAT
AAGAGAGAGGTTTGTAAAAGAATGGACTTGGTCTGCCAGAGAATGTTGAATCAGGGATTTCTGAAAGTGGAGAGGTACCATAATCTATGT
CAGAAACAAGTTAAAGCACAACTCCCAAGGAGAGAGTCAGAAAGGAGAAACCATTCATTAGCTCGTCATGCAGACATTCTTGCTGCTGTT
GAAACAAGGCTGTCACTATTAAATATGACTTTCATGAAATATGTGGATTCCAATCTCTGTTGCTTCATCCCAGGAAAGGTGATTGATGAG
ATTTATCGTGTGTTGAGATATGTCAATTCTACCAGAGCCCCTCAACGAGCTCATGAAGTACTTCAAGAATTAAGGGATATATCCTCTATG
GCAATGGAGTACTTTGATGAAAAGATTGTTCCAATTTTAAAGAGGAAATTACCAGGATCAGATGTTTCTGGAAGACTCATGGGCTCTCCT
CCAGTTCCAGGACCGTCTGCAGCCCTAACAACAATGCAGCTCTTCTCCAAGCAAAATCCTTCAAGACAAGAGGTTACCAAACTCCAGCAG
CAGGTTAAAACAAATGGTGCTGGCGTGACTGTTCTCAGGCGTGAAATTTCTGAGCTTCGCACCAAAGTGCAAGAACAGCAAAAACAGCTT
CAAGACCAGGACCAGAAACTGCTAGAGCAGACCCAGATCATAGGTGAACAAAATGCACGGTTGGCAGAGCTAGAACGCAAACTACGAGAA
GTAATGGAAAGTGCTGTAGGAAATTCCTCAGGGTCCGGGCAGAATGAGGAGTCTCCTCGGAAACGAAAAAAGGCCACGGAAGCCATAGAC
TCTCTTAGGAAATCTAAACGTCTTCGGAATAGAAAGTAAATTGGAATGTGGTTCTAGTTCCAGAGGAAGACACAGCTTAGTAGCTTAAGC
AGTTATGCATATCAGGATACTGTGAGCAACATGGTGTCCCTTAAGCTTCTAGGCTTTCAGAACACAACTTAAACTTGAACTCTTATGGTT
GGGACATTCTTTTCCTGCTTCTCCTGATTGAACTGATGCACAGAATCTTTTTACTTTGCAATAGATTTGTACTAACCAGACCTGTTCTAT
CATGTTTTGAGGAGTTAACTTTTTTCTGTGCAGATAATGTTGAAAGTAAGTTAATTTGTTTCTGCATATATGCACATACATACGTAAGGA
TCTTAAACCCAGTCTTGACAGACTAGAAGTTAAGTTTAATACAGAAAATGTCCTGTTCACTTGAAAGAAAAGACCTACTTTTTAAATGGA
CACTATCTTGGTTCTTTTTTTTTTAAGTCATCTTTTTGTTATAAGTGACCTTTGTCTGGAATGTCTGAAAAGTAGTTAATGCTTTTTGGT
ATTGAAGTAATGGGTAACTAAAATGGACTTCCATAGTATTGACTGTAGAAGGAGCCTCTACAATATTGACTATATATTTTTATAAACTAC
TGGCAAGGAACTTACCCAGCTGTTATACATGTTTTCAGTTCTCTTTGGGGGCCATGTCCTACATTTGCATGGATGGATGCATGCATTGCC
TAGTCAACTCACTTAAAAAGCTCTTGCACTGGTATTGATCTTGAACCTCTATACTTCTCCACTTTTTAGAGCGGCGTCTTAGTTTATTTA
AACGCTTAACATCTTCCACCGCAACAGCTTGCCTCTAGAGGGGGAATTGTTCATCCATTTGTCCTCCAGTTTTATAGGAACAAGAGACTA
TTAAAGCCCATTGCTTTATCTGCTCTCTGTAGGGTTCAGGTACACTGGCTAAGGCAGAACCCCAAATTTCAAGGCTCTTTCTATCAATAT
TGGACCTCTGGGAGCTAATACTCCTCTTTGCTCACCACCATGTGATCATTGATCAGATGTGGTGAGTGAGTAGGGGACTCGACTTGCGGG
ATGCAGTTTTGCCATTGCAGCAAAGTTCATTGAGGAAAATTGTACCATGAAAAAGCATTTTGATTATTTCATTTCTGGAGGATGACCTTG
AGGGAAGCTTTTTAATATTAGTTTCAAGCTTTCCTTACCCTACAACTTTAAACAAAAGCTTTAATTTTGTTTGCACTCCTATTTTGAGCT
TGTAACTGGAAAAGCATGTCTTGCACTGTTCAACCTCCTGAGTGGTCGCTTTAACAACCTCCAAATTGTGTACAGTGGTTATTTTCCCCA
GTTGTATAGTTTTGAGACATTCAATTATCACTGTCTTAGTTGTATTTTAATTTACTAAATTATGTAGCTATTTGACTGTTAAGTTCTTTT
AAACAACTGTTTCCTTGGGCTTCAGTTATTTAAAGTAAATTTAGGTGTAATATAGAAAACTGTCCCTTTCCAGGTGGGAGCTTAACACCT
GTATAAAACCTAAGGTTTTGGTAAGTACCTTAGTTGAATAAAAGCACAAGGTTATCACCTTTTTTATCCGTCCACCGTGACATGGTTATG
CATCCTTTAGATTAACCTCACCAAATGAAGCTTTTTCTATCCATTTTTAATATTGTCCTTACATAATATTGTCCTTAGATTTTGATCAAT
TCTATGTCTGACTTTGAAATTCCATTTACAATGTAGTATGTTTTCAATGAAAAACCATAAAGTAACATCCAAGTGTTTCATGGTTTGTTG
GGAAGGTAATTTTAAAATAAAACAATTTCCAAAAAACATTTGTCAGCCAAGGTCATCCATAAAAGTCCCCGTCTGGAACTCGTTTTCTCA
GCACTTCTCATTTTTATAATCATAGTATTTAGCCATATTAGCATATCTTTAGAGGAGGCCTGGTGGAATACCCGGGGCCTCTACTAGTCT
GCTTTTCCGGTCATAGGAAGACTTTTTTTTTTACGTATCAAAGCATGTGTTTACAGATTTACAGAGTGTGATCCGTATGCATCAAAGGGA
TACAGCCCCAGACTGTTTCTTTAATGGTCATTCATGAACTATTAAAAATTTCCTGAATTTCTTTTTAAACTACATCTAGATAGCCTAAAC
ATCTATGTAGTCTTCCATTAGTTAACATGTGTATAGGGCTTTCATAATAAGTAGTCACACTGTTACAAGGTAAATTTTCTATTACAAAAT
CCAAATTTCTATTGCATACACTTATAATCATCTATTCATAAAGCTAATTCATTGTACTTGTTAATGCATGAATGTTCCATGCAGTAGGAG
AATAAAGCACTACAGTTCGGTTGTTCAAATCTTAAATCTTAGGCTATTTAGCTAAAACATGTTAGGATATTGCCTTCACCACTTGTTAGG
ACAGTTATTTGATAGCCATTATGCTTACCTATGGATAGCATAATGGTATTTAAGGTTCAACAAACCGCAGATTATTATGATCAGCTAGAA
CTGACATATGTTACAAGAAAACTGTAAATTAACCTCCTGAGAGAACCATTCTGCCCTGCATTTTAAGTCAGGTATTTAAATACTGCGTGT
TGTTAATATTGCGTTGTCTTAGTGCAACATTTCTTAAAGTATTCCCGTTATCTTCCTTGGCTGTTTTTCAGAGGAGACGTCTCCATGTTA
ATGGGTCCTTCCCACATAGAAATGTATTCTGGTACAGCGCTGCACACATGGATAGCAATGTGAAAAGGCATGCCTAAGAGACAGAAACGG
CTGACCTTACCCCACCCCAGCCGGATCCTCTGCTTATCTCCCACATGCACTTGGCTTAACTGGTTTTCACAGATTCTGAGGTTATAGAAC
CTGTTGTTTTTCAAACTCCTGTACAGAGCCTGGAAATAATGGAGCAAACGCAAATGTATTGAGAGTCATTATACTTTAAAATAGTTTTAA
AGACTATTGGGGTACCATCAGGTCAAAAGCCACTGATTTGGGAAGCAATTTTTTTGCAAAACACTTTTTTTGGAGTACTGAACTTTACAG
GGGCTTGCCTTAATCTCTATTTAGTAGTTTCAAGATATATGCGCAATTATTCTACGTGTTAAAAATGTTAAAATATTCTATGTAGCCCCA
AAGGTGGGTAAAACAGTATAAGTAATGCCTAAATTAATAAGCTAAAAGGTGTCACTACAGCTGGATTTTTGAGAGAAAATGGACATAAAA
CTAGGCTATGTGTAATAAAAATAATGGCACCTTAAGATTGCACTATTTTATGCATTATTTTATATGCCATTTCATAGCCTGCACTTTAAT
CTCCAAAGAAACGATGTATGATGTCCCACTTGTTCCTTATTCTTAATAAACTTTTTCCTGAGACAGGGCACTTAATTCTATTTTACTATA
CTGAATTAGTTTCTTGGAGGTAGATTCATTTCTTGAGTTCTCTGTTTCCTTAGCCATAATATTTTCTAGGATCCGGGAACTCCCTATATT
GTCTATTTCCAACATTATATAATTTTAATTTAATGTAATGTAAATCTCATACTTGGTGATCAGCACATTCTTATATCCTGCTCTAGCAAT
GAGTACCCATTTGTTACACTTACCAAACTCTCTAAAAACATATACTGTGAGTAAGATTTGAAGCCAGGAATAAAAGGCAGTCTGAAAGAA
AACGTCCTATACGATGCAGTTGTTTGGAAATGGCTGATTTCTGATATGAAACCCAACTTGATACACTGTTTGGTTCTTTGACTTGGGATC
TATCTGAATTGCTTTCACTAGTACACAAAAGGTTAAGTTAAAACTACTTTAAACTTGTATAGCCTGCCATCTGAGGTGAATTATTTTCAA
AAAATACTAAATCTATGAACTGAGACTAGCAATTAGTTGGCTGCTCCCTACCATGATTTTACTTTTAATAGCAATACAGTTATATTGGTG
ATAAATATGACAGGCTTAAGTACTGCTGTCCTTTTGCATCTTCCTAAGCATCTTGGTTAAATTTCTGAAGTTTAAAAATTAGATCCAGAT
TTCTTCTGTTGTGTCTGAAGAGAACCATGACATTTAGAAGTATATTGGTAATCTATTAGGTCCATTGGCAAAGTATATTGGTCCATATTC
AAACCTATTCCAAAAGGTTAGAAGTGTTTAAGATTCCTTTATTGTGGTACCATGTCTGTTTACCTATGCTTATGAGCAACAATAAATTAC
TAGTTTACCTTCTGGAATTTTAATTGTTATAACCGAATCAATTATTGGAAAGTGAAAAACACCTCCCGGTCACACAACAGGGTACGTAAA

>73670_73670_1_RFWD2-FBXO28_RFWD2_chr1_176118141_ENST00000308769_FBXO28_chr1_224318173_ENST00000366862_length(amino acids)=552AA_BP=273
MSGSRQAGSGSAGTSPGSSAASSVTSASSSLSSSPSPPSVAVSAAALVSGGVAQAAGSGGLGGPVRPVLVAPAVSGSGGGAVSTGLSRHS
CAARPSAGVGGSSSSLGSGSRKRPLLAPLCNGLINSYEDKSNDFVCPICFDMIEEAYMTKCGHSFCYKCIHQSLEDNNRCPKCNYVVDNI
DHLYPNFLVNELILKQKQRFEEKRFKLDHSNGHRWQIFQDWLGTDQDNLDLANVNLMLELLVQKKKQLEAESHAAQLQILMEFLKVARRN
KREVCKRMDLVCQRMLNQGFLKVERYHNLCQKQVKAQLPRRESERRNHSLARHADILAAVETRLSLLNMTFMKYVDSNLCCFIPGKVIDE
IYRVLRYVNSTRAPQRAHEVLQELRDISSMAMEYFDEKIVPILKRKLPGSDVSGRLMGSPPVPGPSAALTTMQLFSKQNPSRQEVTKLQQ
QVKTNGAGVTVLRREISELRTKVQEQQKQLQDQDQKLLEQTQIIGEQNARLAELERKLREVMESAVGNSSGSGQNEESPRKRKKATEAID

--------------------------------------------------------------
>73670_73670_2_RFWD2-FBXO28_RFWD2_chr1_176118141_ENST00000308769_FBXO28_chr1_224318173_ENST00000424254_length(transcript)=1867nt_BP=819nt
ATGTCTGGTAGCCGCCAGGCCGGGTCGGGCTCCGCTGGGACAAGCCCCGGGTCCTCGGCGGCCTCCTCGGTGACTTCCGCCTCCTCGTCT
TTATCCTCTTCCCCGTCGCCGCCTTCCGTGGCGGTTTCGGCGGCAGCGCTGGTGTCCGGCGGGGTGGCCCAGGCCGCCGGCTCGGGCGGC
CTCGGGGGCCCGGTGCGGCCTGTGTTGGTGGCGCCCGCCGTATCGGGTAGCGGCGGCGGGGCGGTGTCCACGGGCCTGTCCCGGCACAGC
TGCGCGGCCAGGCCCAGCGCCGGCGTAGGAGGCAGCAGCTCCAGCCTAGGCAGCGGCAGCAGGAAGCGACCTCTCCTCGCCCCCCTCTGC
AACGGGCTCATCAACTCCTACGAGGACAAAAGCAACGACTTCGTATGCCCCATCTGCTTTGATATGATTGAAGAAGCATACATGACAAAA
TGTGGCCACAGCTTTTGCTACAAGTGTATTCATCAGAGTTTGGAGGACAATAATAGATGTCCCAAGTGTAACTATGTTGTGGACAATATT
GACCATCTGTATCCTAATTTCTTGGTGAATGAACTCATTCTTAAACAGAAGCAAAGATTTGAGGAAAAGAGGTTCAAATTGGACCACTCA
AATGGCCACAGGTGGCAGATATTTCAAGATTGGTTGGGAACTGACCAAGATAACCTTGATTTGGCCAATGTCAATCTTATGTTGGAGTTA
CTAGTGCAGAAGAAGAAACAACTGGAAGCAGAATCACATGCAGCCCAACTACAGATTCTTATGGAATTCCTCAAGGTTGCAAGAAGAAAT
AAGAGAGAGGTTTGTAAAAGAATGGACTTGGTCTGCCAGAGAATGTTGAATCAGGGATTTCTGAAAGTGGAGAGGTACCATAATCTATGT
CAGAAACAAGTTAAAGCACAACTCCCAAGGAGAGAGTCAGAAAGGAGAAACCATTCATTAGCTCGTCATGCAGACATTCTTGCTGCTGTT
GAAACAAGGCTGTCACTATTAAATATGACTTTCATGAAATATGTGGATTCCAATCTCTGTTGCTTCATCCCAGGAAAGTTCCAGGACCGT
CTGCAGCCCTAACAACAATGCAGCTCTTCTCCAAGCAAAATCCTTCAAGACAAGAGGTTACCAAACTCCAGCAGCAGGTTAAAACAAATG
GTGCTGGCGTGACTGTTCTCAGGCGTGAAATTTCTGAGCTTCGCACCAAAGTGCAAGAACAGCAAAAACAGCTTCAAGACCAGGACCAGA
AACTGCTAGAGCAGACCCAGATCATAGGTGAACAAAATGCACGGTTGGCAGAGCTAGAACGCAAACTACGAGAAGTAATGGAAAGTGCTG
TAGGAAATTCCTCAGGGTCCGGGCAGAATGAGGAGTCTCCTCGGAAACGAAAAAAGGCCACGGAAGCCATAGACTCTCTTAGGAAATCTA
AACGTCTTCGGAATAGAAAGTAAATTGGAATGTGGTTCTAGTTCCAGAGGAAGACACAGCTTAGTAGCTTAAGCAGTTATGCATATCAGG
ATACTGTGAGCAACATGGTGTCCCTTAAGCTTCTAGGCTTTCAGAACACAACTTAAACTTGAACTCTTATGGTTGGGACATTCTTTTCCT
GCTTCTCCTGATTGAACTGATGCACAGAATCTTTTTACTTTGCAATAGATTTGTACTAACCAGACCTGTTCTATCATGTTTTGAGGAGTT
AACTTTTTTCTGTGCAGATAATGTTGAAAGTAAGTTAATTTGTTTCTGCATATATGCACATACATACGTAAGGATCTTAAACCCAGTCTT

>73670_73670_2_RFWD2-FBXO28_RFWD2_chr1_176118141_ENST00000308769_FBXO28_chr1_224318173_ENST00000424254_length(amino acids)=363AA_BP=273
MSGSRQAGSGSAGTSPGSSAASSVTSASSSLSSSPSPPSVAVSAAALVSGGVAQAAGSGGLGGPVRPVLVAPAVSGSGGGAVSTGLSRHS
CAARPSAGVGGSSSSLGSGSRKRPLLAPLCNGLINSYEDKSNDFVCPICFDMIEEAYMTKCGHSFCYKCIHQSLEDNNRCPKCNYVVDNI
DHLYPNFLVNELILKQKQRFEEKRFKLDHSNGHRWQIFQDWLGTDQDNLDLANVNLMLELLVQKKKQLEAESHAAQLQILMEFLKVARRN
KREVCKRMDLVCQRMLNQGFLKVERYHNLCQKQVKAQLPRRESERRNHSLARHADILAAVETRLSLLNMTFMKYVDSNLCCFIPGKFQDR

--------------------------------------------------------------
>73670_73670_3_RFWD2-FBXO28_RFWD2_chr1_176118141_ENST00000367669_FBXO28_chr1_224318173_ENST00000366862_length(transcript)=6487nt_BP=1346nt
CACCTATACCATTCATTCCAGTCTCCTCAATTCTTTCACTGTATTAAGACGGCCTGCCCTCTGGCACGTTTTCTGGAACGAAAGCGGCTT
GGGACAGACAGACTCCCTTCGCCAGGGAGCCCCGACCCCGAGGGCGCGCCCTGAGCGTCTGAGCGCAGCCCCGCTGCGTCCCCAGTTGTA
TCCCCCGCCACGCCCGCCTCTTCCGCCGCTCGCGCGCGCGCGCACGGCCGGCCACGGCGCGCCGGGGTTGGCTGCTACAGGGACCGCGGT
GGCGGCGGCGGCCTCGACAGCGGTAGTGCCTTCTACTCCGCTTTTTTAGTTTCCTCCGCCCCCTCCCGTGGGACGCTGTTGTGTGGCTGC
CTTAAAAAAAAACGCAACTTTATTGTTCCTCAGCCCCACCTCCGGCTCGGCGGGCGTCCTCAGGATGCACTGAGGCTGAGGGGAGGGGAG
GCGGCGGAGGGTCGAGGTCGCGGTCCCTCTCCTCCGAGCGCCCGGCTGGAGGGGAGGGAGTCACGATGTCTGGTAGCCGCCAGGCCGGGT
CGGGCTCCGCTGGGACAAGCCCCGGGTCCTCGGCGGCCTCCTCGGTGACTTCCGCCTCCTCGTCTTTATCCTCTTCCCCGTCGCCGCCTT
CCGTGGCGGTTTCGGCGGCAGCGCTGGTGTCCGGCGGGGTGGCCCAGGCCGCCGGCTCGGGCGGCCTCGGGGGCCCGGTGCGGCCTGTGT
TGGTGGCGCCCGCCGTATCGGGTAGCGGCGGCGGGGCGGTGTCCACGGGCCTGTCCCGGCACAGCTGCGCGGCCAGGCCCAGCGCCGGCG
TAGGAGGCAGCAGCTCCAGCCTAGGCAGCGGCAGCAGGAAGCGACCTCTCCTCGCCCCCCTCTGCAACGGGCTCATCAACTCCTACGAGG
ACAAAAGCAACGACTTCGTATGCCCCATCTGCTTTGATATGATTGAAGAAGCATACATGACAAAATGTGGCCACAGCTTTTGCTACAAGT
GTATTCATCAGAGTTTGGAGGACAATAATAGATGTCCCAAGTGTAACTATGTTGTGGACAATATTGACCATCTGTATCCTAATTTCTTGG
TGAATGAACTCATTCTTAAACAGAAGCAAAGATTTGAGGAAAAGAGGTTCAAATTGGACCACTCAGTGAGTAGCACCAATGGCCACAGGT
GGCAGATATTTCAAGATTGGTTGGGAACTGACCAAGATAACCTTGATTTGGCCAATGTCAATCTTATGTTGGAGTTACTAGTGCAGAAGA
AGAAACAACTGGAAGCAGAATCACATGCAGCCCAACTACAGATTCTTATGGAATTCCTCAAGGTTGCAAGAAGAAATAAGAGAGAGGTTT
GTAAAAGAATGGACTTGGTCTGCCAGAGAATGTTGAATCAGGGATTTCTGAAAGTGGAGAGGTACCATAATCTATGTCAGAAACAAGTTA
AAGCACAACTCCCAAGGAGAGAGTCAGAAAGGAGAAACCATTCATTAGCTCGTCATGCAGACATTCTTGCTGCTGTTGAAACAAGGCTGT
CACTATTAAATATGACTTTCATGAAATATGTGGATTCCAATCTCTGTTGCTTCATCCCAGGAAAGGTGATTGATGAGATTTATCGTGTGT
TGAGATATGTCAATTCTACCAGAGCCCCTCAACGAGCTCATGAAGTACTTCAAGAATTAAGGGATATATCCTCTATGGCAATGGAGTACT
TTGATGAAAAGATTGTTCCAATTTTAAAGAGGAAATTACCAGGATCAGATGTTTCTGGAAGACTCATGGGCTCTCCTCCAGTTCCAGGAC
CGTCTGCAGCCCTAACAACAATGCAGCTCTTCTCCAAGCAAAATCCTTCAAGACAAGAGGTTACCAAACTCCAGCAGCAGGTTAAAACAA
ATGGTGCTGGCGTGACTGTTCTCAGGCGTGAAATTTCTGAGCTTCGCACCAAAGTGCAAGAACAGCAAAAACAGCTTCAAGACCAGGACC
AGAAACTGCTAGAGCAGACCCAGATCATAGGTGAACAAAATGCACGGTTGGCAGAGCTAGAACGCAAACTACGAGAAGTAATGGAAAGTG
CTGTAGGAAATTCCTCAGGGTCCGGGCAGAATGAGGAGTCTCCTCGGAAACGAAAAAAGGCCACGGAAGCCATAGACTCTCTTAGGAAAT
CTAAACGTCTTCGGAATAGAAAGTAAATTGGAATGTGGTTCTAGTTCCAGAGGAAGACACAGCTTAGTAGCTTAAGCAGTTATGCATATC
AGGATACTGTGAGCAACATGGTGTCCCTTAAGCTTCTAGGCTTTCAGAACACAACTTAAACTTGAACTCTTATGGTTGGGACATTCTTTT
CCTGCTTCTCCTGATTGAACTGATGCACAGAATCTTTTTACTTTGCAATAGATTTGTACTAACCAGACCTGTTCTATCATGTTTTGAGGA
GTTAACTTTTTTCTGTGCAGATAATGTTGAAAGTAAGTTAATTTGTTTCTGCATATATGCACATACATACGTAAGGATCTTAAACCCAGT
CTTGACAGACTAGAAGTTAAGTTTAATACAGAAAATGTCCTGTTCACTTGAAAGAAAAGACCTACTTTTTAAATGGACACTATCTTGGTT
CTTTTTTTTTTAAGTCATCTTTTTGTTATAAGTGACCTTTGTCTGGAATGTCTGAAAAGTAGTTAATGCTTTTTGGTATTGAAGTAATGG
GTAACTAAAATGGACTTCCATAGTATTGACTGTAGAAGGAGCCTCTACAATATTGACTATATATTTTTATAAACTACTGGCAAGGAACTT
ACCCAGCTGTTATACATGTTTTCAGTTCTCTTTGGGGGCCATGTCCTACATTTGCATGGATGGATGCATGCATTGCCTAGTCAACTCACT
TAAAAAGCTCTTGCACTGGTATTGATCTTGAACCTCTATACTTCTCCACTTTTTAGAGCGGCGTCTTAGTTTATTTAAACGCTTAACATC
TTCCACCGCAACAGCTTGCCTCTAGAGGGGGAATTGTTCATCCATTTGTCCTCCAGTTTTATAGGAACAAGAGACTATTAAAGCCCATTG
CTTTATCTGCTCTCTGTAGGGTTCAGGTACACTGGCTAAGGCAGAACCCCAAATTTCAAGGCTCTTTCTATCAATATTGGACCTCTGGGA
GCTAATACTCCTCTTTGCTCACCACCATGTGATCATTGATCAGATGTGGTGAGTGAGTAGGGGACTCGACTTGCGGGATGCAGTTTTGCC
ATTGCAGCAAAGTTCATTGAGGAAAATTGTACCATGAAAAAGCATTTTGATTATTTCATTTCTGGAGGATGACCTTGAGGGAAGCTTTTT
AATATTAGTTTCAAGCTTTCCTTACCCTACAACTTTAAACAAAAGCTTTAATTTTGTTTGCACTCCTATTTTGAGCTTGTAACTGGAAAA
GCATGTCTTGCACTGTTCAACCTCCTGAGTGGTCGCTTTAACAACCTCCAAATTGTGTACAGTGGTTATTTTCCCCAGTTGTATAGTTTT
GAGACATTCAATTATCACTGTCTTAGTTGTATTTTAATTTACTAAATTATGTAGCTATTTGACTGTTAAGTTCTTTTAAACAACTGTTTC
CTTGGGCTTCAGTTATTTAAAGTAAATTTAGGTGTAATATAGAAAACTGTCCCTTTCCAGGTGGGAGCTTAACACCTGTATAAAACCTAA
GGTTTTGGTAAGTACCTTAGTTGAATAAAAGCACAAGGTTATCACCTTTTTTATCCGTCCACCGTGACATGGTTATGCATCCTTTAGATT
AACCTCACCAAATGAAGCTTTTTCTATCCATTTTTAATATTGTCCTTACATAATATTGTCCTTAGATTTTGATCAATTCTATGTCTGACT
TTGAAATTCCATTTACAATGTAGTATGTTTTCAATGAAAAACCATAAAGTAACATCCAAGTGTTTCATGGTTTGTTGGGAAGGTAATTTT
AAAATAAAACAATTTCCAAAAAACATTTGTCAGCCAAGGTCATCCATAAAAGTCCCCGTCTGGAACTCGTTTTCTCAGCACTTCTCATTT
TTATAATCATAGTATTTAGCCATATTAGCATATCTTTAGAGGAGGCCTGGTGGAATACCCGGGGCCTCTACTAGTCTGCTTTTCCGGTCA
TAGGAAGACTTTTTTTTTTACGTATCAAAGCATGTGTTTACAGATTTACAGAGTGTGATCCGTATGCATCAAAGGGATACAGCCCCAGAC
TGTTTCTTTAATGGTCATTCATGAACTATTAAAAATTTCCTGAATTTCTTTTTAAACTACATCTAGATAGCCTAAACATCTATGTAGTCT
TCCATTAGTTAACATGTGTATAGGGCTTTCATAATAAGTAGTCACACTGTTACAAGGTAAATTTTCTATTACAAAATCCAAATTTCTATT
GCATACACTTATAATCATCTATTCATAAAGCTAATTCATTGTACTTGTTAATGCATGAATGTTCCATGCAGTAGGAGAATAAAGCACTAC
AGTTCGGTTGTTCAAATCTTAAATCTTAGGCTATTTAGCTAAAACATGTTAGGATATTGCCTTCACCACTTGTTAGGACAGTTATTTGAT
AGCCATTATGCTTACCTATGGATAGCATAATGGTATTTAAGGTTCAACAAACCGCAGATTATTATGATCAGCTAGAACTGACATATGTTA
CAAGAAAACTGTAAATTAACCTCCTGAGAGAACCATTCTGCCCTGCATTTTAAGTCAGGTATTTAAATACTGCGTGTTGTTAATATTGCG
TTGTCTTAGTGCAACATTTCTTAAAGTATTCCCGTTATCTTCCTTGGCTGTTTTTCAGAGGAGACGTCTCCATGTTAATGGGTCCTTCCC
ACATAGAAATGTATTCTGGTACAGCGCTGCACACATGGATAGCAATGTGAAAAGGCATGCCTAAGAGACAGAAACGGCTGACCTTACCCC
ACCCCAGCCGGATCCTCTGCTTATCTCCCACATGCACTTGGCTTAACTGGTTTTCACAGATTCTGAGGTTATAGAACCTGTTGTTTTTCA
AACTCCTGTACAGAGCCTGGAAATAATGGAGCAAACGCAAATGTATTGAGAGTCATTATACTTTAAAATAGTTTTAAAGACTATTGGGGT
ACCATCAGGTCAAAAGCCACTGATTTGGGAAGCAATTTTTTTGCAAAACACTTTTTTTGGAGTACTGAACTTTACAGGGGCTTGCCTTAA
TCTCTATTTAGTAGTTTCAAGATATATGCGCAATTATTCTACGTGTTAAAAATGTTAAAATATTCTATGTAGCCCCAAAGGTGGGTAAAA
CAGTATAAGTAATGCCTAAATTAATAAGCTAAAAGGTGTCACTACAGCTGGATTTTTGAGAGAAAATGGACATAAAACTAGGCTATGTGT
AATAAAAATAATGGCACCTTAAGATTGCACTATTTTATGCATTATTTTATATGCCATTTCATAGCCTGCACTTTAATCTCCAAAGAAACG
ATGTATGATGTCCCACTTGTTCCTTATTCTTAATAAACTTTTTCCTGAGACAGGGCACTTAATTCTATTTTACTATACTGAATTAGTTTC
TTGGAGGTAGATTCATTTCTTGAGTTCTCTGTTTCCTTAGCCATAATATTTTCTAGGATCCGGGAACTCCCTATATTGTCTATTTCCAAC
ATTATATAATTTTAATTTAATGTAATGTAAATCTCATACTTGGTGATCAGCACATTCTTATATCCTGCTCTAGCAATGAGTACCCATTTG
TTACACTTACCAAACTCTCTAAAAACATATACTGTGAGTAAGATTTGAAGCCAGGAATAAAAGGCAGTCTGAAAGAAAACGTCCTATACG
ATGCAGTTGTTTGGAAATGGCTGATTTCTGATATGAAACCCAACTTGATACACTGTTTGGTTCTTTGACTTGGGATCTATCTGAATTGCT
TTCACTAGTACACAAAAGGTTAAGTTAAAACTACTTTAAACTTGTATAGCCTGCCATCTGAGGTGAATTATTTTCAAAAAATACTAAATC
TATGAACTGAGACTAGCAATTAGTTGGCTGCTCCCTACCATGATTTTACTTTTAATAGCAATACAGTTATATTGGTGATAAATATGACAG
GCTTAAGTACTGCTGTCCTTTTGCATCTTCCTAAGCATCTTGGTTAAATTTCTGAAGTTTAAAAATTAGATCCAGATTTCTTCTGTTGTG
TCTGAAGAGAACCATGACATTTAGAAGTATATTGGTAATCTATTAGGTCCATTGGCAAAGTATATTGGTCCATATTCAAACCTATTCCAA
AAGGTTAGAAGTGTTTAAGATTCCTTTATTGTGGTACCATGTCTGTTTACCTATGCTTATGAGCAACAATAAATTACTAGTTTACCTTCT
GGAATTTTAATTGTTATAACCGAATCAATTATTGGAAAGTGAAAAACACCTCCCGGTCACACAACAGGGTACGTAAATAAATGTGTTGTT

>73670_73670_3_RFWD2-FBXO28_RFWD2_chr1_176118141_ENST00000367669_FBXO28_chr1_224318173_ENST00000366862_length(amino acids)=556AA_BP=277
MSGSRQAGSGSAGTSPGSSAASSVTSASSSLSSSPSPPSVAVSAAALVSGGVAQAAGSGGLGGPVRPVLVAPAVSGSGGGAVSTGLSRHS
CAARPSAGVGGSSSSLGSGSRKRPLLAPLCNGLINSYEDKSNDFVCPICFDMIEEAYMTKCGHSFCYKCIHQSLEDNNRCPKCNYVVDNI
DHLYPNFLVNELILKQKQRFEEKRFKLDHSVSSTNGHRWQIFQDWLGTDQDNLDLANVNLMLELLVQKKKQLEAESHAAQLQILMEFLKV
ARRNKREVCKRMDLVCQRMLNQGFLKVERYHNLCQKQVKAQLPRRESERRNHSLARHADILAAVETRLSLLNMTFMKYVDSNLCCFIPGK
VIDEIYRVLRYVNSTRAPQRAHEVLQELRDISSMAMEYFDEKIVPILKRKLPGSDVSGRLMGSPPVPGPSAALTTMQLFSKQNPSRQEVT
KLQQQVKTNGAGVTVLRREISELRTKVQEQQKQLQDQDQKLLEQTQIIGEQNARLAELERKLREVMESAVGNSSGSGQNEESPRKRKKAT

--------------------------------------------------------------
>73670_73670_4_RFWD2-FBXO28_RFWD2_chr1_176118141_ENST00000367669_FBXO28_chr1_224318173_ENST00000424254_length(transcript)=2394nt_BP=1346nt
CACCTATACCATTCATTCCAGTCTCCTCAATTCTTTCACTGTATTAAGACGGCCTGCCCTCTGGCACGTTTTCTGGAACGAAAGCGGCTT
GGGACAGACAGACTCCCTTCGCCAGGGAGCCCCGACCCCGAGGGCGCGCCCTGAGCGTCTGAGCGCAGCCCCGCTGCGTCCCCAGTTGTA
TCCCCCGCCACGCCCGCCTCTTCCGCCGCTCGCGCGCGCGCGCACGGCCGGCCACGGCGCGCCGGGGTTGGCTGCTACAGGGACCGCGGT
GGCGGCGGCGGCCTCGACAGCGGTAGTGCCTTCTACTCCGCTTTTTTAGTTTCCTCCGCCCCCTCCCGTGGGACGCTGTTGTGTGGCTGC
CTTAAAAAAAAACGCAACTTTATTGTTCCTCAGCCCCACCTCCGGCTCGGCGGGCGTCCTCAGGATGCACTGAGGCTGAGGGGAGGGGAG
GCGGCGGAGGGTCGAGGTCGCGGTCCCTCTCCTCCGAGCGCCCGGCTGGAGGGGAGGGAGTCACGATGTCTGGTAGCCGCCAGGCCGGGT
CGGGCTCCGCTGGGACAAGCCCCGGGTCCTCGGCGGCCTCCTCGGTGACTTCCGCCTCCTCGTCTTTATCCTCTTCCCCGTCGCCGCCTT
CCGTGGCGGTTTCGGCGGCAGCGCTGGTGTCCGGCGGGGTGGCCCAGGCCGCCGGCTCGGGCGGCCTCGGGGGCCCGGTGCGGCCTGTGT
TGGTGGCGCCCGCCGTATCGGGTAGCGGCGGCGGGGCGGTGTCCACGGGCCTGTCCCGGCACAGCTGCGCGGCCAGGCCCAGCGCCGGCG
TAGGAGGCAGCAGCTCCAGCCTAGGCAGCGGCAGCAGGAAGCGACCTCTCCTCGCCCCCCTCTGCAACGGGCTCATCAACTCCTACGAGG
ACAAAAGCAACGACTTCGTATGCCCCATCTGCTTTGATATGATTGAAGAAGCATACATGACAAAATGTGGCCACAGCTTTTGCTACAAGT
GTATTCATCAGAGTTTGGAGGACAATAATAGATGTCCCAAGTGTAACTATGTTGTGGACAATATTGACCATCTGTATCCTAATTTCTTGG
TGAATGAACTCATTCTTAAACAGAAGCAAAGATTTGAGGAAAAGAGGTTCAAATTGGACCACTCAGTGAGTAGCACCAATGGCCACAGGT
GGCAGATATTTCAAGATTGGTTGGGAACTGACCAAGATAACCTTGATTTGGCCAATGTCAATCTTATGTTGGAGTTACTAGTGCAGAAGA
AGAAACAACTGGAAGCAGAATCACATGCAGCCCAACTACAGATTCTTATGGAATTCCTCAAGGTTGCAAGAAGAAATAAGAGAGAGGTTT
GTAAAAGAATGGACTTGGTCTGCCAGAGAATGTTGAATCAGGGATTTCTGAAAGTGGAGAGGTACCATAATCTATGTCAGAAACAAGTTA
AAGCACAACTCCCAAGGAGAGAGTCAGAAAGGAGAAACCATTCATTAGCTCGTCATGCAGACATTCTTGCTGCTGTTGAAACAAGGCTGT
CACTATTAAATATGACTTTCATGAAATATGTGGATTCCAATCTCTGTTGCTTCATCCCAGGAAAGTTCCAGGACCGTCTGCAGCCCTAAC
AACAATGCAGCTCTTCTCCAAGCAAAATCCTTCAAGACAAGAGGTTACCAAACTCCAGCAGCAGGTTAAAACAAATGGTGCTGGCGTGAC
TGTTCTCAGGCGTGAAATTTCTGAGCTTCGCACCAAAGTGCAAGAACAGCAAAAACAGCTTCAAGACCAGGACCAGAAACTGCTAGAGCA
GACCCAGATCATAGGTGAACAAAATGCACGGTTGGCAGAGCTAGAACGCAAACTACGAGAAGTAATGGAAAGTGCTGTAGGAAATTCCTC
AGGGTCCGGGCAGAATGAGGAGTCTCCTCGGAAACGAAAAAAGGCCACGGAAGCCATAGACTCTCTTAGGAAATCTAAACGTCTTCGGAA
TAGAAAGTAAATTGGAATGTGGTTCTAGTTCCAGAGGAAGACACAGCTTAGTAGCTTAAGCAGTTATGCATATCAGGATACTGTGAGCAA
CATGGTGTCCCTTAAGCTTCTAGGCTTTCAGAACACAACTTAAACTTGAACTCTTATGGTTGGGACATTCTTTTCCTGCTTCTCCTGATT
GAACTGATGCACAGAATCTTTTTACTTTGCAATAGATTTGTACTAACCAGACCTGTTCTATCATGTTTTGAGGAGTTAACTTTTTTCTGT
GCAGATAATGTTGAAAGTAAGTTAATTTGTTTCTGCATATATGCACATACATACGTAAGGATCTTAAACCCAGTCTTGACAGACTAGAAG

>73670_73670_4_RFWD2-FBXO28_RFWD2_chr1_176118141_ENST00000367669_FBXO28_chr1_224318173_ENST00000424254_length(amino acids)=367AA_BP=277
MSGSRQAGSGSAGTSPGSSAASSVTSASSSLSSSPSPPSVAVSAAALVSGGVAQAAGSGGLGGPVRPVLVAPAVSGSGGGAVSTGLSRHS
CAARPSAGVGGSSSSLGSGSRKRPLLAPLCNGLINSYEDKSNDFVCPICFDMIEEAYMTKCGHSFCYKCIHQSLEDNNRCPKCNYVVDNI
DHLYPNFLVNELILKQKQRFEEKRFKLDHSVSSTNGHRWQIFQDWLGTDQDNLDLANVNLMLELLVQKKKQLEAESHAAQLQILMEFLKV
ARRNKREVCKRMDLVCQRMLNQGFLKVERYHNLCQKQVKAQLPRRESERRNHSLARHADILAAVETRLSLLNMTFMKYVDSNLCCFIPGK

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for RFWD2-FBXO28

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	RFWD2	chr1:176118141	chr1:224318173	ENST00000308769	-	6	19	643_645	273.0	708.0	TRIB1
Hgene	RFWD2	chr1:176118141	chr1:224318173	ENST00000367669	-	6	20	643_645	277.0	732.0	TRIB1

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for RFWD2-FBXO28

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for RFWD2-FBXO28

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source