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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:RFX3-PLGRKT (FusionGDB2 ID:73713)

Fusion Gene Summary for RFX3-PLGRKT

Fusion gene summary

Fusion gene information	Fusion gene name: RFX3-PLGRKT
	Fusion gene ID: 73713
		Hgene	Tgene
	Gene symbol	RFX3	PLGRKT
	Gene ID	5991	55848
	Gene name	regulatory factor X3	plasminogen receptor with a C-terminal lysine
	Synonyms	-	AD025\|C9orf46\|MDS030\|PLG-RKT\|Plg-R(KT)
	Cytomap	9p24.2	9p24.1
	Type of gene	protein-coding	protein-coding
	Description	transcription factor RFX3DNA binding protein RFX3regulatory factor X, 3 (influences HLA class II expression)	plasminogen receptor (KT)5033414D02Rikplasminogen receptor, C-terminal lysine transmembrane proteintransmembrane protein C9orf46
	Modification date	20200327	20200313
	UniProtAcc	.	Q9HBL7
	Ensembl transtripts involved in fusion gene	ENST00000302303, ENST00000358730, ENST00000381984, ENST00000382004,	ENST00000482696, ENST00000223864,
Fusion gene scores	* DoF score	22 X 15 X 9=2970	12 X 5 X 9=540
	# samples	24	13
	** MAII score	log2(24/2970*10)=-3.62935662007961 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/540*10)=-2.05444778402238 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: RFX3 [Title/Abstract] AND PLGRKT [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	RFX3(3395472)-PLGRKT(5361888), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RFX3	GO:0045892	negative regulation of transcription, DNA-templated	12411430
Hgene	RFX3	GO:0045893	positive regulation of transcription, DNA-templated	20148032

Fusion gene breakpoints across RFX3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PLGRKT (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	UCEC	TCGA-EY-A4KR-01A	RFX3	chr9	3395472	-	PLGRKT	chr9	5361888	-
ChimerDB4	UCEC	TCGA-EY-A4KR	RFX3	chr9	3395471	-	PLGRKT	chr9	5361888	-

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Fusion Gene ORF analysis for RFX3-PLGRKT

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000302303	ENST00000482696	RFX3	chr9	3395472	-	PLGRKT	chr9	5361888	-
5CDS-5UTR	ENST00000302303	ENST00000482696	RFX3	chr9	3395471	-	PLGRKT	chr9	5361888	-
5CDS-5UTR	ENST00000358730	ENST00000482696	RFX3	chr9	3395472	-	PLGRKT	chr9	5361888	-
5CDS-5UTR	ENST00000358730	ENST00000482696	RFX3	chr9	3395471	-	PLGRKT	chr9	5361888	-
5CDS-5UTR	ENST00000381984	ENST00000482696	RFX3	chr9	3395472	-	PLGRKT	chr9	5361888	-
5CDS-5UTR	ENST00000381984	ENST00000482696	RFX3	chr9	3395471	-	PLGRKT	chr9	5361888	-
5CDS-5UTR	ENST00000382004	ENST00000482696	RFX3	chr9	3395472	-	PLGRKT	chr9	5361888	-
5CDS-5UTR	ENST00000382004	ENST00000482696	RFX3	chr9	3395471	-	PLGRKT	chr9	5361888	-
In-frame	ENST00000302303	ENST00000223864	RFX3	chr9	3395472	-	PLGRKT	chr9	5361888	-
In-frame	ENST00000302303	ENST00000223864	RFX3	chr9	3395471	-	PLGRKT	chr9	5361888	-
In-frame	ENST00000358730	ENST00000223864	RFX3	chr9	3395472	-	PLGRKT	chr9	5361888	-
In-frame	ENST00000358730	ENST00000223864	RFX3	chr9	3395471	-	PLGRKT	chr9	5361888	-
In-frame	ENST00000381984	ENST00000223864	RFX3	chr9	3395472	-	PLGRKT	chr9	5361888	-
In-frame	ENST00000381984	ENST00000223864	RFX3	chr9	3395471	-	PLGRKT	chr9	5361888	-
In-frame	ENST00000382004	ENST00000223864	RFX3	chr9	3395472	-	PLGRKT	chr9	5361888	-
In-frame	ENST00000382004	ENST00000223864	RFX3	chr9	3395471	-	PLGRKT	chr9	5361888	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000382004	RFX3	chr9	3395472	-	ENST00000223864	PLGRKT	chr9	5361888	-	1058	429	312	791	159
ENST00000358730	RFX3	chr9	3395472	-	ENST00000223864	PLGRKT	chr9	5361888	-	754	125	8	487	159
ENST00000302303	RFX3	chr9	3395472	-	ENST00000223864	PLGRKT	chr9	5361888	-	1058	429	312	791	159
ENST00000381984	RFX3	chr9	3395472	-	ENST00000223864	PLGRKT	chr9	5361888	-	746	117	0	479	159
ENST00000382004	RFX3	chr9	3395471	-	ENST00000223864	PLGRKT	chr9	5361888	-	1058	429	312	791	159
ENST00000358730	RFX3	chr9	3395471	-	ENST00000223864	PLGRKT	chr9	5361888	-	754	125	8	487	159
ENST00000302303	RFX3	chr9	3395471	-	ENST00000223864	PLGRKT	chr9	5361888	-	1058	429	312	791	159
ENST00000381984	RFX3	chr9	3395471	-	ENST00000223864	PLGRKT	chr9	5361888	-	746	117	0	479	159

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000382004	ENST00000223864	RFX3	chr9	3395472	-	PLGRKT	chr9	5361888	-	0.008316919	0.9916831
ENST00000358730	ENST00000223864	RFX3	chr9	3395472	-	PLGRKT	chr9	5361888	-	0.010586664	0.98941326
ENST00000302303	ENST00000223864	RFX3	chr9	3395472	-	PLGRKT	chr9	5361888	-	0.008316919	0.9916831
ENST00000381984	ENST00000223864	RFX3	chr9	3395472	-	PLGRKT	chr9	5361888	-	0.01015339	0.98984665
ENST00000382004	ENST00000223864	RFX3	chr9	3395471	-	PLGRKT	chr9	5361888	-	0.008316919	0.9916831
ENST00000358730	ENST00000223864	RFX3	chr9	3395471	-	PLGRKT	chr9	5361888	-	0.010586664	0.98941326
ENST00000302303	ENST00000223864	RFX3	chr9	3395471	-	PLGRKT	chr9	5361888	-	0.008316919	0.9916831
ENST00000381984	ENST00000223864	RFX3	chr9	3395471	-	PLGRKT	chr9	5361888	-	0.01015339	0.98984665

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Fusion Genomic Features for RFX3-PLGRKT

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RFX3-PLGRKT

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:3395472/chr9:5361888)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	PLGRKT Q9HBL7
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Receptor for plasminogen. Regulates urokinase plasminogen activator-dependent and stimulates tissue-type plasminogen activator-dependent cell surface plasminogen activation. Proposed to be part of a local catecholaminergic cell plasminogen activation system that regulates neuroendocrine prohormone processing. Involved in regulation of inflammatory response; regulates monocyte chemotactic migration and matrix metalloproteinase activation, such as of MMP2 and MMP9. {ECO:0000269\|PubMed:21940822}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

PLGRKT

chr9:3395471

chr9:5361888

ENST00000223864

100_147

148.0

Topological domain

Extracellular

Tgene

PLGRKT

chr9:3395471

chr9:5361888

ENST00000223864

74_78

148.0

Topological domain

Cytoplasmic

Tgene

PLGRKT

chr9:3395472

chr9:5361888

ENST00000223864

100_147

148.0

Topological domain

Extracellular

Tgene

PLGRKT

chr9:3395472

chr9:5361888

ENST00000223864

74_78

148.0

Topological domain

Cytoplasmic

Tgene

PLGRKT

chr9:3395471

chr9:5361888

ENST00000223864

53_73

148.0

Transmembrane

Helical

Tgene

PLGRKT

chr9:3395471

chr9:5361888

ENST00000223864

79_99

148.0

Transmembrane

Helical

Tgene

PLGRKT

chr9:3395472

chr9:5361888

ENST00000223864

53_73

148.0

Transmembrane

Helical

Tgene

PLGRKT

chr9:3395472

chr9:5361888

ENST00000223864

79_99

148.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RFX3

chr9:3395471

chr9:5361888

ENST00000302303

183_258

708.0

DNA binding

RFX-type winged-helix

Hgene

RFX3

chr9:3395471

chr9:5361888

ENST00000358730

183_258

708.0

DNA binding

RFX-type winged-helix

Hgene

RFX3

chr9:3395471

chr9:5361888

ENST00000382004

183_258

750.0

DNA binding

RFX-type winged-helix

Hgene

RFX3

chr9:3395472

chr9:5361888

ENST00000302303

183_258

708.0

DNA binding

RFX-type winged-helix

Hgene

RFX3

chr9:3395472

chr9:5361888

ENST00000358730

183_258

708.0

DNA binding

RFX-type winged-helix

Hgene

RFX3

chr9:3395472

chr9:5361888

ENST00000382004

183_258

750.0

DNA binding

RFX-type winged-helix

Tgene

PLGRKT

chr9:3395471

chr9:5361888

ENST00000223864

1_52

148.0

Topological domain

Extracellular

Tgene

PLGRKT

chr9:3395472

chr9:5361888

ENST00000223864

1_52

148.0

Topological domain

Extracellular

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Fusion Gene Sequence for RFX3-PLGRKT

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>73713_73713_1_RFX3-PLGRKT_RFX3_chr9_3395471_ENST00000302303_PLGRKT_chr9_5361888_ENST00000223864_length(transcript)=1058nt_BP=429nt
CGTGCGAGTGTCTCCCTCTCCCTCTCGCTCTCTCTCTCTCTCCCTCTCTCTCTCTCTTTTGTGAGTTATAGCAACCGTTGCCTTGTGAAT
CAAGCGCCATAGTCACCGTAGTCCTGGCGACTGTTACCCATCAACAACAACTACTCCTCTCCTCCTCCTCCTCCTCTTCCTCCTCCTCCT
CCCCACCACCACCATCTCCATCACCCACCAACAACACCACAATAATCCACAGCCAAGGCCACTTGGTCATTCTGGCATTTTATGGTAGAG
AATACGTTGAGTTTGGCTCTGGAAGGAATATGAGAGACCATCATGCAGACATCAGAGACTGGGTCGGACACAGGCTCGACAGTGACCTTA
CAAACATCTGTGGCTAGTCAAGCAGCAGTGCCTACGCAGGTGGTACAGCAAGTACCAGTACAACAACAGCTGGAAAGGCAGCTCATCATG
CAGAGTGAAATGAGGGAAAGACAAATGGCCATGCAGATTGCGTGGTCTCGGGAATTCCTCAAATATTTTGGAACTTTTTTTGGCCTTGCA
GCCATCTCTTTAACAGCTGGAGCGATTAAAAAAAAGAAGCCAGCCTTCCTGGTCCCGATTGTTCCATTAAGCTTTATCCTCACCTACCAG
TATGACTTGGGCTATGGAACCCTTTTAGAAAGAATGAAAGGTGAAGCTGAGGACATACTGGAAACAGAAAAGAGTAAATTGCAGCTGCCA
AGAGGAATGATCACTTTTGAAAGCATTGAAAAAGCCAGAAAGGAACAGAGTAGATTCTTCATAGACAAATGAAATCATGCTTACCAATCA
AATCTCAAAGCACAGAATTATTGACTTGAATCATGGTTTTTACAGTTTTTTAAATGCTCAAGATTTTGATATTATAGATTTTATTTTAAA
ATATTAAAATGCAAGATAGTTTTGAGCTATTTTAAAATAAAATTTATAACATTCAACACAAAATCATGGAGGTGCTCTAAATAACTTTTA

>73713_73713_1_RFX3-PLGRKT_RFX3_chr9_3395471_ENST00000302303_PLGRKT_chr9_5361888_ENST00000223864_length(amino acids)=159AA_BP=39
MQTSETGSDTGSTVTLQTSVASQAAVPTQVVQQVPVQQQLERQLIMQSEMRERQMAMQIAWSREFLKYFGTFFGLAAISLTAGAIKKKKP

--------------------------------------------------------------
>73713_73713_2_RFX3-PLGRKT_RFX3_chr9_3395471_ENST00000358730_PLGRKT_chr9_5361888_ENST00000223864_length(transcript)=754nt_BP=125nt
AGACCATCATGCAGACATCAGAGACTGGGTCGGACACAGGCTCGACAGTGACCTTACAAACATCTGTGGCTAGTCAAGCAGCAGTGCCTA
CGCAGGTGGTACAGCAAGTACCAGTACAACAACAGCTGGAAAGGCAGCTCATCATGCAGAGTGAAATGAGGGAAAGACAAATGGCCATGC
AGATTGCGTGGTCTCGGGAATTCCTCAAATATTTTGGAACTTTTTTTGGCCTTGCAGCCATCTCTTTAACAGCTGGAGCGATTAAAAAAA
AGAAGCCAGCCTTCCTGGTCCCGATTGTTCCATTAAGCTTTATCCTCACCTACCAGTATGACTTGGGCTATGGAACCCTTTTAGAAAGAA
TGAAAGGTGAAGCTGAGGACATACTGGAAACAGAAAAGAGTAAATTGCAGCTGCCAAGAGGAATGATCACTTTTGAAAGCATTGAAAAAG
CCAGAAAGGAACAGAGTAGATTCTTCATAGACAAATGAAATCATGCTTACCAATCAAATCTCAAAGCACAGAATTATTGACTTGAATCAT
GGTTTTTACAGTTTTTTAAATGCTCAAGATTTTGATATTATAGATTTTATTTTAAAATATTAAAATGCAAGATAGTTTTGAGCTATTTTA
AAATAAAATTTATAACATTCAACACAAAATCATGGAGGTGCTCTAAATAACTTTTAGATTTCCTCTCTCTGTGTGCATTACCAATATCTA

>73713_73713_2_RFX3-PLGRKT_RFX3_chr9_3395471_ENST00000358730_PLGRKT_chr9_5361888_ENST00000223864_length(amino acids)=159AA_BP=39
MQTSETGSDTGSTVTLQTSVASQAAVPTQVVQQVPVQQQLERQLIMQSEMRERQMAMQIAWSREFLKYFGTFFGLAAISLTAGAIKKKKP

--------------------------------------------------------------
>73713_73713_3_RFX3-PLGRKT_RFX3_chr9_3395471_ENST00000381984_PLGRKT_chr9_5361888_ENST00000223864_length(transcript)=746nt_BP=117nt
ATGCAGACATCAGAGACTGGGTCGGACACAGGCTCGACAGTGACCTTACAAACATCTGTGGCTAGTCAAGCAGCAGTGCCTACGCAGGTG
GTACAGCAAGTACCAGTACAACAACAGCTGGAAAGGCAGCTCATCATGCAGAGTGAAATGAGGGAAAGACAAATGGCCATGCAGATTGCG
TGGTCTCGGGAATTCCTCAAATATTTTGGAACTTTTTTTGGCCTTGCAGCCATCTCTTTAACAGCTGGAGCGATTAAAAAAAAGAAGCCA
GCCTTCCTGGTCCCGATTGTTCCATTAAGCTTTATCCTCACCTACCAGTATGACTTGGGCTATGGAACCCTTTTAGAAAGAATGAAAGGT
GAAGCTGAGGACATACTGGAAACAGAAAAGAGTAAATTGCAGCTGCCAAGAGGAATGATCACTTTTGAAAGCATTGAAAAAGCCAGAAAG
GAACAGAGTAGATTCTTCATAGACAAATGAAATCATGCTTACCAATCAAATCTCAAAGCACAGAATTATTGACTTGAATCATGGTTTTTA
CAGTTTTTTAAATGCTCAAGATTTTGATATTATAGATTTTATTTTAAAATATTAAAATGCAAGATAGTTTTGAGCTATTTTAAAATAAAA
TTTATAACATTCAACACAAAATCATGGAGGTGCTCTAAATAACTTTTAGATTTCCTCTCTCTGTGTGCATTACCAATATCTAAGTGTAAA

>73713_73713_3_RFX3-PLGRKT_RFX3_chr9_3395471_ENST00000381984_PLGRKT_chr9_5361888_ENST00000223864_length(amino acids)=159AA_BP=39
MQTSETGSDTGSTVTLQTSVASQAAVPTQVVQQVPVQQQLERQLIMQSEMRERQMAMQIAWSREFLKYFGTFFGLAAISLTAGAIKKKKP

--------------------------------------------------------------
>73713_73713_4_RFX3-PLGRKT_RFX3_chr9_3395471_ENST00000382004_PLGRKT_chr9_5361888_ENST00000223864_length(transcript)=1058nt_BP=429nt
CGTGCGAGTGTCTCCCTCTCCCTCTCGCTCTCTCTCTCTCTCCCTCTCTCTCTCTCTTTTGTGAGTTATAGCAACCGTTGCCTTGTGAAT
CAAGCGCCATAGTCACCGTAGTCCTGGCGACTGTTACCCATCAACAACAACTACTCCTCTCCTCCTCCTCCTCCTCTTCCTCCTCCTCCT
CCCCACCACCACCATCTCCATCACCCACCAACAACACCACAATAATCCACAGCCAAGGCCACTTGGTCATTCTGGCATTTTATGGTAGAG
AATACGTTGAGTTTGGCTCTGGAAGGAATATGAGAGACCATCATGCAGACATCAGAGACTGGGTCGGACACAGGCTCGACAGTGACCTTA
CAAACATCTGTGGCTAGTCAAGCAGCAGTGCCTACGCAGGTGGTACAGCAAGTACCAGTACAACAACAGCTGGAAAGGCAGCTCATCATG
CAGAGTGAAATGAGGGAAAGACAAATGGCCATGCAGATTGCGTGGTCTCGGGAATTCCTCAAATATTTTGGAACTTTTTTTGGCCTTGCA
GCCATCTCTTTAACAGCTGGAGCGATTAAAAAAAAGAAGCCAGCCTTCCTGGTCCCGATTGTTCCATTAAGCTTTATCCTCACCTACCAG
TATGACTTGGGCTATGGAACCCTTTTAGAAAGAATGAAAGGTGAAGCTGAGGACATACTGGAAACAGAAAAGAGTAAATTGCAGCTGCCA
AGAGGAATGATCACTTTTGAAAGCATTGAAAAAGCCAGAAAGGAACAGAGTAGATTCTTCATAGACAAATGAAATCATGCTTACCAATCA
AATCTCAAAGCACAGAATTATTGACTTGAATCATGGTTTTTACAGTTTTTTAAATGCTCAAGATTTTGATATTATAGATTTTATTTTAAA
ATATTAAAATGCAAGATAGTTTTGAGCTATTTTAAAATAAAATTTATAACATTCAACACAAAATCATGGAGGTGCTCTAAATAACTTTTA

>73713_73713_4_RFX3-PLGRKT_RFX3_chr9_3395471_ENST00000382004_PLGRKT_chr9_5361888_ENST00000223864_length(amino acids)=159AA_BP=39
MQTSETGSDTGSTVTLQTSVASQAAVPTQVVQQVPVQQQLERQLIMQSEMRERQMAMQIAWSREFLKYFGTFFGLAAISLTAGAIKKKKP

--------------------------------------------------------------
>73713_73713_5_RFX3-PLGRKT_RFX3_chr9_3395472_ENST00000302303_PLGRKT_chr9_5361888_ENST00000223864_length(transcript)=1058nt_BP=429nt
CGTGCGAGTGTCTCCCTCTCCCTCTCGCTCTCTCTCTCTCTCCCTCTCTCTCTCTCTTTTGTGAGTTATAGCAACCGTTGCCTTGTGAAT
CAAGCGCCATAGTCACCGTAGTCCTGGCGACTGTTACCCATCAACAACAACTACTCCTCTCCTCCTCCTCCTCCTCTTCCTCCTCCTCCT
CCCCACCACCACCATCTCCATCACCCACCAACAACACCACAATAATCCACAGCCAAGGCCACTTGGTCATTCTGGCATTTTATGGTAGAG
AATACGTTGAGTTTGGCTCTGGAAGGAATATGAGAGACCATCATGCAGACATCAGAGACTGGGTCGGACACAGGCTCGACAGTGACCTTA
CAAACATCTGTGGCTAGTCAAGCAGCAGTGCCTACGCAGGTGGTACAGCAAGTACCAGTACAACAACAGCTGGAAAGGCAGCTCATCATG
CAGAGTGAAATGAGGGAAAGACAAATGGCCATGCAGATTGCGTGGTCTCGGGAATTCCTCAAATATTTTGGAACTTTTTTTGGCCTTGCA
GCCATCTCTTTAACAGCTGGAGCGATTAAAAAAAAGAAGCCAGCCTTCCTGGTCCCGATTGTTCCATTAAGCTTTATCCTCACCTACCAG
TATGACTTGGGCTATGGAACCCTTTTAGAAAGAATGAAAGGTGAAGCTGAGGACATACTGGAAACAGAAAAGAGTAAATTGCAGCTGCCA
AGAGGAATGATCACTTTTGAAAGCATTGAAAAAGCCAGAAAGGAACAGAGTAGATTCTTCATAGACAAATGAAATCATGCTTACCAATCA
AATCTCAAAGCACAGAATTATTGACTTGAATCATGGTTTTTACAGTTTTTTAAATGCTCAAGATTTTGATATTATAGATTTTATTTTAAA
ATATTAAAATGCAAGATAGTTTTGAGCTATTTTAAAATAAAATTTATAACATTCAACACAAAATCATGGAGGTGCTCTAAATAACTTTTA

>73713_73713_5_RFX3-PLGRKT_RFX3_chr9_3395472_ENST00000302303_PLGRKT_chr9_5361888_ENST00000223864_length(amino acids)=159AA_BP=39
MQTSETGSDTGSTVTLQTSVASQAAVPTQVVQQVPVQQQLERQLIMQSEMRERQMAMQIAWSREFLKYFGTFFGLAAISLTAGAIKKKKP

--------------------------------------------------------------
>73713_73713_6_RFX3-PLGRKT_RFX3_chr9_3395472_ENST00000358730_PLGRKT_chr9_5361888_ENST00000223864_length(transcript)=754nt_BP=125nt
AGACCATCATGCAGACATCAGAGACTGGGTCGGACACAGGCTCGACAGTGACCTTACAAACATCTGTGGCTAGTCAAGCAGCAGTGCCTA
CGCAGGTGGTACAGCAAGTACCAGTACAACAACAGCTGGAAAGGCAGCTCATCATGCAGAGTGAAATGAGGGAAAGACAAATGGCCATGC
AGATTGCGTGGTCTCGGGAATTCCTCAAATATTTTGGAACTTTTTTTGGCCTTGCAGCCATCTCTTTAACAGCTGGAGCGATTAAAAAAA
AGAAGCCAGCCTTCCTGGTCCCGATTGTTCCATTAAGCTTTATCCTCACCTACCAGTATGACTTGGGCTATGGAACCCTTTTAGAAAGAA
TGAAAGGTGAAGCTGAGGACATACTGGAAACAGAAAAGAGTAAATTGCAGCTGCCAAGAGGAATGATCACTTTTGAAAGCATTGAAAAAG
CCAGAAAGGAACAGAGTAGATTCTTCATAGACAAATGAAATCATGCTTACCAATCAAATCTCAAAGCACAGAATTATTGACTTGAATCAT
GGTTTTTACAGTTTTTTAAATGCTCAAGATTTTGATATTATAGATTTTATTTTAAAATATTAAAATGCAAGATAGTTTTGAGCTATTTTA
AAATAAAATTTATAACATTCAACACAAAATCATGGAGGTGCTCTAAATAACTTTTAGATTTCCTCTCTCTGTGTGCATTACCAATATCTA

>73713_73713_6_RFX3-PLGRKT_RFX3_chr9_3395472_ENST00000358730_PLGRKT_chr9_5361888_ENST00000223864_length(amino acids)=159AA_BP=39
MQTSETGSDTGSTVTLQTSVASQAAVPTQVVQQVPVQQQLERQLIMQSEMRERQMAMQIAWSREFLKYFGTFFGLAAISLTAGAIKKKKP

--------------------------------------------------------------
>73713_73713_7_RFX3-PLGRKT_RFX3_chr9_3395472_ENST00000381984_PLGRKT_chr9_5361888_ENST00000223864_length(transcript)=746nt_BP=117nt
ATGCAGACATCAGAGACTGGGTCGGACACAGGCTCGACAGTGACCTTACAAACATCTGTGGCTAGTCAAGCAGCAGTGCCTACGCAGGTG
GTACAGCAAGTACCAGTACAACAACAGCTGGAAAGGCAGCTCATCATGCAGAGTGAAATGAGGGAAAGACAAATGGCCATGCAGATTGCG
TGGTCTCGGGAATTCCTCAAATATTTTGGAACTTTTTTTGGCCTTGCAGCCATCTCTTTAACAGCTGGAGCGATTAAAAAAAAGAAGCCA
GCCTTCCTGGTCCCGATTGTTCCATTAAGCTTTATCCTCACCTACCAGTATGACTTGGGCTATGGAACCCTTTTAGAAAGAATGAAAGGT
GAAGCTGAGGACATACTGGAAACAGAAAAGAGTAAATTGCAGCTGCCAAGAGGAATGATCACTTTTGAAAGCATTGAAAAAGCCAGAAAG
GAACAGAGTAGATTCTTCATAGACAAATGAAATCATGCTTACCAATCAAATCTCAAAGCACAGAATTATTGACTTGAATCATGGTTTTTA
CAGTTTTTTAAATGCTCAAGATTTTGATATTATAGATTTTATTTTAAAATATTAAAATGCAAGATAGTTTTGAGCTATTTTAAAATAAAA
TTTATAACATTCAACACAAAATCATGGAGGTGCTCTAAATAACTTTTAGATTTCCTCTCTCTGTGTGCATTACCAATATCTAAGTGTAAA

>73713_73713_7_RFX3-PLGRKT_RFX3_chr9_3395472_ENST00000381984_PLGRKT_chr9_5361888_ENST00000223864_length(amino acids)=159AA_BP=39
MQTSETGSDTGSTVTLQTSVASQAAVPTQVVQQVPVQQQLERQLIMQSEMRERQMAMQIAWSREFLKYFGTFFGLAAISLTAGAIKKKKP

--------------------------------------------------------------
>73713_73713_8_RFX3-PLGRKT_RFX3_chr9_3395472_ENST00000382004_PLGRKT_chr9_5361888_ENST00000223864_length(transcript)=1058nt_BP=429nt
CGTGCGAGTGTCTCCCTCTCCCTCTCGCTCTCTCTCTCTCTCCCTCTCTCTCTCTCTTTTGTGAGTTATAGCAACCGTTGCCTTGTGAAT
CAAGCGCCATAGTCACCGTAGTCCTGGCGACTGTTACCCATCAACAACAACTACTCCTCTCCTCCTCCTCCTCCTCTTCCTCCTCCTCCT
CCCCACCACCACCATCTCCATCACCCACCAACAACACCACAATAATCCACAGCCAAGGCCACTTGGTCATTCTGGCATTTTATGGTAGAG
AATACGTTGAGTTTGGCTCTGGAAGGAATATGAGAGACCATCATGCAGACATCAGAGACTGGGTCGGACACAGGCTCGACAGTGACCTTA
CAAACATCTGTGGCTAGTCAAGCAGCAGTGCCTACGCAGGTGGTACAGCAAGTACCAGTACAACAACAGCTGGAAAGGCAGCTCATCATG
CAGAGTGAAATGAGGGAAAGACAAATGGCCATGCAGATTGCGTGGTCTCGGGAATTCCTCAAATATTTTGGAACTTTTTTTGGCCTTGCA
GCCATCTCTTTAACAGCTGGAGCGATTAAAAAAAAGAAGCCAGCCTTCCTGGTCCCGATTGTTCCATTAAGCTTTATCCTCACCTACCAG
TATGACTTGGGCTATGGAACCCTTTTAGAAAGAATGAAAGGTGAAGCTGAGGACATACTGGAAACAGAAAAGAGTAAATTGCAGCTGCCA
AGAGGAATGATCACTTTTGAAAGCATTGAAAAAGCCAGAAAGGAACAGAGTAGATTCTTCATAGACAAATGAAATCATGCTTACCAATCA
AATCTCAAAGCACAGAATTATTGACTTGAATCATGGTTTTTACAGTTTTTTAAATGCTCAAGATTTTGATATTATAGATTTTATTTTAAA
ATATTAAAATGCAAGATAGTTTTGAGCTATTTTAAAATAAAATTTATAACATTCAACACAAAATCATGGAGGTGCTCTAAATAACTTTTA

>73713_73713_8_RFX3-PLGRKT_RFX3_chr9_3395472_ENST00000382004_PLGRKT_chr9_5361888_ENST00000223864_length(amino acids)=159AA_BP=39
MQTSETGSDTGSTVTLQTSVASQAAVPTQVVQQVPVQQQLERQLIMQSEMRERQMAMQIAWSREFLKYFGTFFGLAAISLTAGAIKKKKP

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for RFX3-PLGRKT

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for RFX3-PLGRKT

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for RFX3-PLGRKT

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source