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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RGPD8-GPR39 (FusionGDB2 ID:73790)

Fusion Gene Summary for RGPD8-GPR39

check button Fusion gene summary
Fusion gene informationFusion gene name: RGPD8-GPR39
Fusion gene ID: 73790
HgeneTgene
Gene symbol

RGPD8

GPR39

Gene ID

727851

2863

Gene nameRANBP2 like and GRIP domain containing 8G protein-coupled receptor 39
SynonymsRANBP2L1|RGP8|RanBP2alpha-
Cytomap

2q14.1

2q21.2

Type of geneprotein-codingprotein-coding
DescriptionRANBP2-like and GRIP domain-containing protein 8RAN binding protein 2-like 1ran-binding protein 2-like 3ranBP2-like 3ranBP2L3G-protein coupled receptor 39
Modification date2020031320200313
UniProtAcc.

O43194

Ensembl transtripts involved in fusion geneENST00000302558, ENST00000330575, 
ENST00000409750, 		ENST00000470071, 
ENST00000329321, 
Fusion gene scores* DoF score2 X 2 X 2=87 X 5 X 4=140
# samples 28
** MAII scorelog2(2/8*10)=1.32192809488736log2(8/140*10)=-0.807354922057604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RGPD8 [Title/Abstract] AND GPR39 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRGPD8(113152195)-GPR39(133402674), # samples:1
Anticipated loss of major functional domain due to fusion event.RGPD8-GPR39 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across RGPD8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GPR39 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-14-0871-01ARGPD8chr2

113152195

-GPR39chr2

133402674

+


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Fusion Gene ORF analysis for RGPD8-GPR39

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000302558ENST00000470071RGPD8chr2

113152195

-GPR39chr2

133402674

+
5CDS-3UTRENST00000330575ENST00000470071RGPD8chr2

113152195

-GPR39chr2

133402674

+
5CDS-3UTRENST00000409750ENST00000470071RGPD8chr2

113152195

-GPR39chr2

133402674

+
Frame-shiftENST00000409750ENST00000329321RGPD8chr2

113152195

-GPR39chr2

133402674

+
In-frameENST00000302558ENST00000329321RGPD8chr2

113152195

-GPR39chr2

133402674

+
In-frameENST00000330575ENST00000329321RGPD8chr2

113152195

-GPR39chr2

133402674

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000302558RGPD8chr2113152195-ENST00000329321GPR39chr2133402674+425327949332991068
ENST00000330575RGPD8chr2113152195-ENST00000329321GPR39chr2133402674+41382679831841058

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000302558ENST00000329321RGPD8chr2113152195-GPR39chr2133402674+0.0005625740.9994374
ENST00000330575ENST00000329321RGPD8chr2113152195-GPR39chr2133402674+0.0004696520.9995303

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Fusion Genomic Features for RGPD8-GPR39


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RGPD8chr2113152194-GPR39chr2133402673+1.83E-070.99999976
RGPD8chr2113152194-GPR39chr2133402673+1.83E-070.99999976

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for RGPD8-GPR39


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:113152195/chr2:133402674)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GPR39

O43194

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Zn(2+) acts as an agonist. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated mainly through G(q)-alpha and G(12)/G(13) proteins. Involved in regulation of body weight, gastrointestinal mobility, hormone secretion and cell death (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRGPD8chr2:113152195chr2:133402674ENST00000302558-182326_598671766.0RepeatNote=TPR 1
HgeneRGPD8chr2:113152195chr2:133402674ENST00000302558-182360_938671766.0RepeatNote=TPR 2
HgeneRGPD8chr2:113152195chr2:133402674ENST00000302558-1823648_6818671766.0RepeatNote=TPR 3
TgeneGPR39chr2:113152195chr2:133402674ENST0000032932102306_323285454.0Topological domainExtracellular
TgeneGPR39chr2:113152195chr2:133402674ENST0000032932102345_453285454.0Topological domainCytoplasmic
TgeneGPR39chr2:113152195chr2:133402674ENST0000032932102284_305285454.0TransmembraneHelical%3B Name%3D6
TgeneGPR39chr2:113152195chr2:133402674ENST0000032932102324_344285454.0TransmembraneHelical%3B Name%3D7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRGPD8chr2:113152195chr2:133402674ENST00000302558-18231261_12668671766.0Compositional biasNote=Poly-Ser
HgeneRGPD8chr2:113152195chr2:133402674ENST00000302558-18231036_11728671766.0DomainRanBD1 1
HgeneRGPD8chr2:113152195chr2:133402674ENST00000302558-18231333_14698671766.0DomainRanBD1 2
HgeneRGPD8chr2:113152195chr2:133402674ENST00000302558-18231702_17528671766.0DomainGRIP
TgeneGPR39chr2:113152195chr2:133402674ENST0000032932102132_151285454.0Topological domainCytoplasmic
TgeneGPR39chr2:113152195chr2:133402674ENST0000032932102173_217285454.0Topological domainExtracellular
TgeneGPR39chr2:113152195chr2:133402674ENST00000329321021_34285454.0Topological domainExtracellular
TgeneGPR39chr2:113152195chr2:133402674ENST0000032932102243_283285454.0Topological domainCytoplasmic
TgeneGPR39chr2:113152195chr2:133402674ENST000003293210256_69285454.0Topological domainCytoplasmic
TgeneGPR39chr2:113152195chr2:133402674ENST000003293210290_109285454.0Topological domainExtracellular
TgeneGPR39chr2:113152195chr2:133402674ENST0000032932102110_131285454.0TransmembraneHelical%3B Name%3D3
TgeneGPR39chr2:113152195chr2:133402674ENST0000032932102152_172285454.0TransmembraneHelical%3B Name%3D4
TgeneGPR39chr2:113152195chr2:133402674ENST0000032932102218_242285454.0TransmembraneHelical%3B Name%3D5
TgeneGPR39chr2:113152195chr2:133402674ENST000003293210235_55285454.0TransmembraneHelical%3B Name%3D1
TgeneGPR39chr2:113152195chr2:133402674ENST000003293210270_89285454.0TransmembraneHelical%3B Name%3D2


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Fusion Gene Sequence for RGPD8-GPR39


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>73790_73790_1_RGPD8-GPR39_RGPD8_chr2_113152195_ENST00000302558_GPR39_chr2_133402674_ENST00000329321_length(transcript)=4253nt_BP=2794nt
ACACAGTGCTGAGGCAGAACGCAGGTTCGTCACAGTGGGCCTCCGTGGGCGGCGCCGCACGCTCGTCACAGTGGGCCTCCGCCGGCTACG
CCGCTGCTTCAGTGGCTTGCAGGCACTTTCCTCTTGGAAGTGGCGACTGCTGCGGGGCTGAGCGGTGCTCGCACGCGTCTCGGGAGCCAG
GTTGGCGGCGCGATGAGGCGCAGCAAGGCCGATGTGGAGCGGTACGTCGCCTCGGTGCTGGGTCTCACCCCGTCGCCTCGACAGAAGTCA
ATGAAAGGATTCTATTTTGCAAAGCTGTATTATGAAGCTAAAGAATATGATCTTGCTAAAAAATACATATGTACTTACATTAATGTGCAA
GAGAGGGATCCCAAAGCTCACAGATTTCTGGGTCTTCTTTATGAATTGGAAGAAAACACAGAGAAAGCCGTTGAATGTTACAGGCGTTCA
GTGGAATTAAACCCAACACAAAAAGATCTTGTGTTGAAGATTGCAGAATTGCTTTGTAAAAATGATGTTACTGATGGAAGAGCAAAATAC
TGGGTCGAAAGAGCAGCAAAACTTTTCCCAGGAAGTCCTGCAATTTATAAACTAAAGGAACAGCTTCTAGATTGTGAAGGTGAAGATGGA
TGGAATAAACTTTTTGACTTGATTCAGTCAGAACTTTATGTAAGACCTGATGACGTCCATGTGAACATCCGGCTAGTGGAGTTGTATCGC
TCAACTAAAAGATTGAAGGATGCTGTGGCCCACTGCCATGAGGCAGAGAGGAACATAGCTTTGCGTTCAAGTTTAGAGTGGAATTCGTGT
GTTGTACAGACCCTTAAGGAATATCTGGAGTCTTTACAGTGTTTGGAGTCTGATAAAAGTGACTGGCGAGCAACCAATACAGACTTACTG
CTGGCCTATGCTAATCTTATGCTTCTTACGCTTTCCACTAGAGATGTGCAGGAAAATAGAGAATTACTGGAAAGTTTTGATAGTGCTCTT
CAGTCTGCGAAATCTTCTTTGGGTGGAAATGATGAACTGTCAGCTACTTTCTTAGAAATGAAAGGACATTTCTATATGTATGCTGGTTCT
CTGCTCTTGAAGATGGGTCAGCATGGTAATAATGTTCAATGGCGAGCTCTTTCTGAGCTGGCTGCATTGTGCTATCTCATAGCATTTCAG
GTTCCAAGACCAAAGATTAAATTAAGAGAAGGTAAAGCTGGACAAAATCTGCTGGAAATGATGGCCTGTGACCGACTGAGCCAATCAGGG
CACATGTTGCTAAGCTTAAGTCGTGGCAAGCAAGATTTCTTAAAAGAGGTTGTTGAAACTTTTGCCAACAAAATTGGGCAGTCTGCGTTA
TATGATGCTCTGTTTTCTAGTCAGTCACCTAAGGATACATCTTTTCTTGGTAGCGATGATATTGGAAAAATTGATGTACAAGAACCAGAG
CTTGAAGATTTGGCTAGATACGATGTTGGTGCTATTCGAGCACATAATGGTAGTCTTCAGCATCTTACTTGGCTTGGCTTACAGTGGAAT
TCATTGCCTGCTTTACCTGGAATCCGAAAATGGCTAAAACAGCTTTTCCATCGTTTGCCCCATGAAACCTCAAGGCTTGAAACAAATGCG
CCTGAATCAATATGTATTTTAGATCTTGAAGTATTTCTCCTTGGAGTAGTATATACCAGCCACTTACAATTAAAGGAGAAATGTAATTCT
CACCATAGCTCCTATCAGCCGTTATGCCTGCCCTTTCCTGTGTGTAAACAGCTTTGTACAGAAAGACAAAAATCTTGGTGGGATGCGGTT
TGTACTCTGATTCACAGAAAAGCAGTACCTGGAAACTTGGCAAAATTGAGACTTCTAGTTCAGCATGAAATAAACACTCTAAGAGCCCAG
GAAAAACATGGCCTTCAACCTGCTCTGCTTGTACATTGGGCAAAATACCTTCAGAAAACGGGCAGCGGTCTTAATTCTTTTTATGGTCAA
CTAGAATACATAGGGAGAAGTGTTCATTATTGGAAGAAAGTTTTGCCATTGTTGAAGATAATAAAGAAGAACAGTATTCCTGAACCTATT
GATCCTCTGTTTAAACATTTTCATAGTGTAGACATTCAGGCATCAGAAATTGTTGAATATGAAGAAGACGCACACATAACTTTTGCTATA
TTGGATGCAGTAAATGGAAATATAGAAGATGCTGTGACTGCTTTTGAATCTATAAAAAGTGTTGTTTCTTATTGGAATCTTGCACTGATT
TTTCACAGGAAGGCAGAAGACATTGAAAATGATGCCCTTTCTCCTGAAGAACAAGAAGAATGCAGAAATTATCTGACAAAGACCAGGGAC
TACCTAATAAAGATTATAGATGACGGTGATTCAAATCTTTCAGTGGTCAAGAAATTGCCTGTGCCCCTGGAGTCTGTAAAACAGATGCTT
AATTCAGTCATGCAGGAACTCGAAGACTATAGTGAAGGAGGTCCTCTCTATAAAAATGGTTCTTTGCGAAATGCAGATTCAGAAATAAAA
CATTCTACACCGTCTCCTACCAAATATTCACTATCACCAAGTAAAAGTTACAAGTATTCTCCCGAAACACCACCTCGATGGACAGAAGAT
CGGAATTCTTTACTGAATATGATTTGCCAACAAGTAGAGGCCATTAAGAAAGAAATGCAGGAGTTGAAACTAAATAGCAGTAAGTCAGCA
TCCCGTCATCGTTGGCCCACAGAGAATTATGGACCAGACTCGGTGCCTGATGGATATCAGGGGTCACAGACATTTCATGGGGCTCCACTA
ACAGGGCTGATTGTTGTGACATTGGCCGTATGCTGGATGCCCAACCAGATTCGGAGGATCATGGCTGCGGCCAAACCCAAGCACGACTGG
ACGAGGTCCTACTTCCGGGCGTACATGATCCTCCTCCCCTTCTCGGAGACGTTTTTCTACCTCAGCTCGGTCATCAACCCGCTCCTGTAC
ACGGTGTCCTCGCAGCAGTTTCGGCGGGTGTTCGTGCAGGTGCTGTGCTGCCGCCTGTCGCTGCAGCACGCCAACCACGAGAAGCGCCTG
CGCGTACATGCGCACTCCACCACCGACAGCGCCCGCTTTGTGCAGCGCCCGTTGCTCTTCGCGTCCCGGCGCCAGTCCTCTGCAAGGAGA
ACTGAGAAGATTTTCTTAAGCACTTTTCAGAGCGAGGCCGAGCCCCAGTCTAAGTCCCAGTCATTGAGTCTCGAGTCACTAGAGCCCAAC
TCAGGCGCGAAACCAGCCAATTCTGCTGCAGAGAATGGTTTTCAGGAGCATGAAGTTTGAATGTCAAGCGAGGGAGCCTTGAGTGGGAAC
TGGCCCTCCAGCCCTAAGAAAACGTCACTCTCACTCTGCAGTCTCAAACTATGCCCCCATCAGGGATGGAATGGACACTGGAGGCTTTAC
AAAAGGCAGATGCCCACCTCAGTGACTTCTAAGGACTGACTCTGCCAGCCTGGCCTTGACTCCGGTTACACAGACATGGGGGTGAACTTT
CACTCCACCTCCTTCCTTCAAGTACATACTGAAAATTCAGTCAGGCTGAATTTATTCAGAATGCTTTACCGAGCTCTTTCATTATTTGCA
CAGGAACAAAAGAGAACACGGACTCCCGCTCCCTACCCAGAATAAAAGGACACCCAGAAGAAACTCACTCAGGGAGGTGGGGGGTTGGGG
GCGAGGGCTGGAAGAACAATGCAGGAGGGGGTGGCATCTCCTTCAGCTTCAGCAGTGTGCCGAGAAGAGGGCTAATTTGAGGAACAGGAT
GGTGGTGCGGAGCCCTGGCCTGAGGGCCGAGGCAGAACTTCCCCTTTTCTTGGGCCTTGGCCCGTTACAAAGAGGGGTGTTGCAGCAGCT
GATGCAAACTGAGTTCAGTTTCCCTGGGGAGCAGAAGGACTGGTACCCGGCAGAGGCGATGAGACAGGCCGCTGATGATGCACAGGACTT
GCGGTACATGATCCCTGTAACACAGACCCAAAGGAGCTGAGTTAACGTGCACCGGCAAAAGAATAGCTGTCCCTCTCAGCCCAAATCCAA
ACGGACAGCTCTTCCTTACTCCTCCCACAGCCCAGAGACTAGGTGAGGTCAGGGAAGTGCTTCGGATTGTCTCATTGATATTCAAGATAG
ATGGTGAAAGAGACAGGCACTATTTCATTAGTTTTAACAAAACTGTTCCAAAAGCGATTTGAGATGCCAATACCTGTGAATACCTGTTAA

>73790_73790_1_RGPD8-GPR39_RGPD8_chr2_113152195_ENST00000302558_GPR39_chr2_133402674_ENST00000329321_length(amino acids)=1068AA_BP=900
MLQWLAGTFLLEVATAAGLSGARTRLGSQVGGAMRRSKADVERYVASVLGLTPSPRQKSMKGFYFAKLYYEAKEYDLAKKYICTYINVQE
RDPKAHRFLGLLYELEENTEKAVECYRRSVELNPTQKDLVLKIAELLCKNDVTDGRAKYWVERAAKLFPGSPAIYKLKEQLLDCEGEDGW
NKLFDLIQSELYVRPDDVHVNIRLVELYRSTKRLKDAVAHCHEAERNIALRSSLEWNSCVVQTLKEYLESLQCLESDKSDWRATNTDLLL
AYANLMLLTLSTRDVQENRELLESFDSALQSAKSSLGGNDELSATFLEMKGHFYMYAGSLLLKMGQHGNNVQWRALSELAALCYLIAFQV
PRPKIKLREGKAGQNLLEMMACDRLSQSGHMLLSLSRGKQDFLKEVVETFANKIGQSALYDALFSSQSPKDTSFLGSDDIGKIDVQEPEL
EDLARYDVGAIRAHNGSLQHLTWLGLQWNSLPALPGIRKWLKQLFHRLPHETSRLETNAPESICILDLEVFLLGVVYTSHLQLKEKCNSH
HSSYQPLCLPFPVCKQLCTERQKSWWDAVCTLIHRKAVPGNLAKLRLLVQHEINTLRAQEKHGLQPALLVHWAKYLQKTGSGLNSFYGQL
EYIGRSVHYWKKVLPLLKIIKKNSIPEPIDPLFKHFHSVDIQASEIVEYEEDAHITFAILDAVNGNIEDAVTAFESIKSVVSYWNLALIF
HRKAEDIENDALSPEEQEECRNYLTKTRDYLIKIIDDGDSNLSVVKKLPVPLESVKQMLNSVMQELEDYSEGGPLYKNGSLRNADSEIKH
STPSPTKYSLSPSKSYKYSPETPPRWTEDRNSLLNMICQQVEAIKKEMQELKLNSSKSASRHRWPTENYGPDSVPDGYQGSQTFHGAPLT
GLIVVTLAVCWMPNQIRRIMAAAKPKHDWTRSYFRAYMILLPFSETFFYLSSVINPLLYTVSSQQFRRVFVQVLCCRLSLQHANHEKRLR

--------------------------------------------------------------
>73790_73790_2_RGPD8-GPR39_RGPD8_chr2_113152195_ENST00000330575_GPR39_chr2_133402674_ENST00000329321_length(transcript)=4138nt_BP=2679nt
CTTTCCTCTTGGAAGTGGCGACTGCTGCGGGGCTGAGCGGTGCTCGCACGCGTCTCGGGAGCCAGGTTGGCGGCGCGATGAGGCGCAGCA
AGGCCGATGTGGAGCGGTACGTCGCCTCGGTGCTGGGTCTCACCCCGTCGCCTCGACAGAAGTCAATGAAAGGATTCTATTTTGCAAAGC
TGTATTATGAAGCTAAAGAATATGATCTTGCTAAAAAATACATATGTACTTACATTAATGTGCAAGAGAGGGATCCCAAAGCTCACAGAT
TTCTGGGTCTTCTTTATGAATTGGAAGAAAACACAGAGAAAGCCGTTGAATGTTACAGGCGTTCAGTGGAATTAAACCCAACACAAAAAG
ATCTTGTGTTGAAGATTGCAGAATTGCTTTGTAAAAATGATGTTACTGATGGAAGAGCAAAATACTGGGTCGAAAGAGCAGCAAAACTTT
TCCCAGGAAGTCCTGCAATTTATAAACTAAAGGAACAGCTTCTAGATTGTGAAGGTGAAGATGGATGGAATAAACTTTTTGACTTGATTC
AGTCAGAACTTTATGTAAGACCTGATGACGTCCATGTGAACATCCGGCTAGTGGAGTTGTATCGCTCAACTAAAAGATTGAAGGATGCTG
TGGCCCACTGCCATGAGGCAGAGAGGAACATAGCTTTGCGTTCAAGTTTAGAGTGGAATTCGTGTGTTGTACAGACCCTTAAGGAATATC
TGGAGTCTTTACAGTGTTTGGAGTCTGATAAAAGTGACTGGCGAGCAACCAATACAGACTTACTGCTGGCCTATGCTAATCTTATGCTTC
TTACGCTTTCCACTAGAGATGTGCAGGAAAATAGAGAATTACTGGAAAGTTTTGATAGTGCTCTTCAGTCTGCGAAATCTTCTTTGGGTG
GAAATGATGAACTGTCAGCTACTTTCTTAGAAATGAAAGGACATTTCTATATGTATGCTGGTTCTCTGCTCTTGAAGATGGGTCAGCATG
GTAATAATGTTCAATGGCGAGCTCTTTCTGAGCTGGCTGCATTGTGCTATCTCATAGCATTTCAGGTTCCAAGACCAAAGATTAAATTAA
GAGAAGGTAAAGCTGGACAAAATCTGCTGGAAATGATGGCCTGTGACCGACTGAGCCAATCAGGGCACATGTTGCTAAGCTTAAGTCGTG
GCAAGCAAGATTTCTTAAAAGAGGTTGTTGAAACTTTTGCCAACAAAATTGGGCAGTCTGCGTTATATGATGCTCTGTTTTCTAGTCAGT
CACCTAAGGATACATCTTTTCTTGGTAGCGATGATATTGGAAAAATTGATGTACAAGAACCAGAGCTTGAAGATTTGGCTAGATACGATG
TTGGTGCTATTCGAGCACATAATGGTAGTCTTCAGCATCTTACTTGGCTTGGCTTACAGTGGAATTCATTGCCTGCTTTACCTGGAATCC
GAAAATGGCTAAAACAGCTTTTCCATCGTTTGCCCCATGAAACCTCAAGGCTTGAAACAAATGCGCCTGAATCAATATGTATTTTAGATC
TTGAAGTATTTCTCCTTGGAGTAGTATATACCAGCCACTTACAATTAAAGGAGAAATGTAATTCTCACCATAGCTCCTATCAGCCGTTAT
GCCTGCCCTTTCCTGTGTGTAAACAGCTTTGTACAGAAAGACAAAAATCTTGGTGGGATGCGGTTTGTACTCTGATTCACAGAAAAGCAG
TACCTGGAAACTTGGCAAAATTGAGACTTCTAGTTCAGCATGAAATAAACACTCTAAGAGCCCAGGAAAAACATGGCCTTCAACCTGCTC
TGCTTGTACATTGGGCAAAATACCTTCAGAAAACGGGCAGCGGTCTTAATTCTTTTTATGGTCAACTAGAATACATAGGGAGAAGTGTTC
ATTATTGGAAGAAAGTTTTGCCATTGTTGAAGATAATAAAGAAGAACAGTATTCCTGAACCTATTGATCCTCTGTTTAAACATTTTCATA
GTGTAGACATTCAGGCATCAGAAATTGTTGAATATGAAGAAGACGCACACATAACTTTTGCTATATTGGATGCAGTAAATGGAAATATAG
AAGATGCTGTGACTGCTTTTGAATCTATAAAAAGTGTTGTTTCTTATTGGAATCTTGCACTGATTTTTCACAGGAAGGCAGAAGACATTG
AAAATGATGCCCTTTCTCCTGAAGAACAAGAAGAATGCAGAAATTATCTGACAAAGACCAGGGACTACCTAATAAAGATTATAGATGACG
GTGATTCAAATCTTTCAGTGGTCAAGAAATTGCCTGTGCCCCTGGAGTCTGTAAAACAGATGCTTAATTCAGTCATGCAGGAACTCGAAG
ACTATAGTGAAGGAGGTCCTCTCTATAAAAATGGTTCTTTGCGAAATGCAGATTCAGAAATAAAACATTCTACACCGTCTCCTACCAAAT
ATTCACTATCACCAAGTAAAAGTTACAAGTATTCTCCCGAAACACCACCTCGATGGACAGAAGATCGGAATTCTTTACTGAATATGATTT
GCCAACAAGTAGAGGCCATTAAGAAAGAAATGCAGGAGTTGAAACTAAATAGCAGTAAGTCAGCATCCCGTCATCGTTGGCCCACAGAGA
ATTATGGACCAGACTCGGTGCCTGATGGATATCAGGGGTCACAGACATTTCATGGGGCTCCACTAACAGGGCTGATTGTTGTGACATTGG
CCGTATGCTGGATGCCCAACCAGATTCGGAGGATCATGGCTGCGGCCAAACCCAAGCACGACTGGACGAGGTCCTACTTCCGGGCGTACA
TGATCCTCCTCCCCTTCTCGGAGACGTTTTTCTACCTCAGCTCGGTCATCAACCCGCTCCTGTACACGGTGTCCTCGCAGCAGTTTCGGC
GGGTGTTCGTGCAGGTGCTGTGCTGCCGCCTGTCGCTGCAGCACGCCAACCACGAGAAGCGCCTGCGCGTACATGCGCACTCCACCACCG
ACAGCGCCCGCTTTGTGCAGCGCCCGTTGCTCTTCGCGTCCCGGCGCCAGTCCTCTGCAAGGAGAACTGAGAAGATTTTCTTAAGCACTT
TTCAGAGCGAGGCCGAGCCCCAGTCTAAGTCCCAGTCATTGAGTCTCGAGTCACTAGAGCCCAACTCAGGCGCGAAACCAGCCAATTCTG
CTGCAGAGAATGGTTTTCAGGAGCATGAAGTTTGAATGTCAAGCGAGGGAGCCTTGAGTGGGAACTGGCCCTCCAGCCCTAAGAAAACGT
CACTCTCACTCTGCAGTCTCAAACTATGCCCCCATCAGGGATGGAATGGACACTGGAGGCTTTACAAAAGGCAGATGCCCACCTCAGTGA
CTTCTAAGGACTGACTCTGCCAGCCTGGCCTTGACTCCGGTTACACAGACATGGGGGTGAACTTTCACTCCACCTCCTTCCTTCAAGTAC
ATACTGAAAATTCAGTCAGGCTGAATTTATTCAGAATGCTTTACCGAGCTCTTTCATTATTTGCACAGGAACAAAAGAGAACACGGACTC
CCGCTCCCTACCCAGAATAAAAGGACACCCAGAAGAAACTCACTCAGGGAGGTGGGGGGTTGGGGGCGAGGGCTGGAAGAACAATGCAGG
AGGGGGTGGCATCTCCTTCAGCTTCAGCAGTGTGCCGAGAAGAGGGCTAATTTGAGGAACAGGATGGTGGTGCGGAGCCCTGGCCTGAGG
GCCGAGGCAGAACTTCCCCTTTTCTTGGGCCTTGGCCCGTTACAAAGAGGGGTGTTGCAGCAGCTGATGCAAACTGAGTTCAGTTTCCCT
GGGGAGCAGAAGGACTGGTACCCGGCAGAGGCGATGAGACAGGCCGCTGATGATGCACAGGACTTGCGGTACATGATCCCTGTAACACAG
ACCCAAAGGAGCTGAGTTAACGTGCACCGGCAAAAGAATAGCTGTCCCTCTCAGCCCAAATCCAAACGGACAGCTCTTCCTTACTCCTCC
CACAGCCCAGAGACTAGGTGAGGTCAGGGAAGTGCTTCGGATTGTCTCATTGATATTCAAGATAGATGGTGAAAGAGACAGGCACTATTT

>73790_73790_2_RGPD8-GPR39_RGPD8_chr2_113152195_ENST00000330575_GPR39_chr2_133402674_ENST00000329321_length(amino acids)=1058AA_BP=890
MEVATAAGLSGARTRLGSQVGGAMRRSKADVERYVASVLGLTPSPRQKSMKGFYFAKLYYEAKEYDLAKKYICTYINVQERDPKAHRFLG
LLYELEENTEKAVECYRRSVELNPTQKDLVLKIAELLCKNDVTDGRAKYWVERAAKLFPGSPAIYKLKEQLLDCEGEDGWNKLFDLIQSE
LYVRPDDVHVNIRLVELYRSTKRLKDAVAHCHEAERNIALRSSLEWNSCVVQTLKEYLESLQCLESDKSDWRATNTDLLLAYANLMLLTL
STRDVQENRELLESFDSALQSAKSSLGGNDELSATFLEMKGHFYMYAGSLLLKMGQHGNNVQWRALSELAALCYLIAFQVPRPKIKLREG
KAGQNLLEMMACDRLSQSGHMLLSLSRGKQDFLKEVVETFANKIGQSALYDALFSSQSPKDTSFLGSDDIGKIDVQEPELEDLARYDVGA
IRAHNGSLQHLTWLGLQWNSLPALPGIRKWLKQLFHRLPHETSRLETNAPESICILDLEVFLLGVVYTSHLQLKEKCNSHHSSYQPLCLP
FPVCKQLCTERQKSWWDAVCTLIHRKAVPGNLAKLRLLVQHEINTLRAQEKHGLQPALLVHWAKYLQKTGSGLNSFYGQLEYIGRSVHYW
KKVLPLLKIIKKNSIPEPIDPLFKHFHSVDIQASEIVEYEEDAHITFAILDAVNGNIEDAVTAFESIKSVVSYWNLALIFHRKAEDIEND
ALSPEEQEECRNYLTKTRDYLIKIIDDGDSNLSVVKKLPVPLESVKQMLNSVMQELEDYSEGGPLYKNGSLRNADSEIKHSTPSPTKYSL
SPSKSYKYSPETPPRWTEDRNSLLNMICQQVEAIKKEMQELKLNSSKSASRHRWPTENYGPDSVPDGYQGSQTFHGAPLTGLIVVTLAVC
WMPNQIRRIMAAAKPKHDWTRSYFRAYMILLPFSETFFYLSSVINPLLYTVSSQQFRRVFVQVLCCRLSLQHANHEKRLRVHAHSTTDSA

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Fusion Gene PPI Analysis for RGPD8-GPR39


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RGPD8-GPR39


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RGPD8-GPR39


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource