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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RGS12-PDZRN3 (FusionGDB2 ID:73799)

Fusion Gene Summary for RGS12-PDZRN3

check button Fusion gene summary
Fusion gene informationFusion gene name: RGS12-PDZRN3
Fusion gene ID: 73799
HgeneTgene
Gene symbol

RGS12

PDZRN3

Gene ID

6002

23024

Gene nameregulator of G protein signaling 12PDZ domain containing ring finger 3
Synonyms-LNX3|SEMACAP3|SEMCAP3
Cytomap

4p16.3

3p13

Type of geneprotein-codingprotein-coding
Descriptionregulator of G-protein signaling 12regulator of G-protein signalling 12E3 ubiquitin-protein ligase PDZRN3RING-type E3 ubiquitin transferase PDZRN3ligand of Numb protein X 3likely ortholog of mouse semaF cytoplasmic domain associated protein 3semaphorin cytoplasmic domain-associated protein 3
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000336727, ENST00000344733, 
ENST00000382788, ENST00000543385, 
ENST00000306648, ENST00000338806, 
ENST00000508158, ENST00000538395, 
ENST00000308537, ENST00000462146, 
ENST00000466348, ENST00000466780, 
ENST00000479530, ENST00000535920, 
ENST00000263666, 
Fusion gene scores* DoF score10 X 8 X 7=5603 X 5 X 3=45
# samples 105
** MAII scorelog2(10/560*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/45*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RGS12 [Title/Abstract] AND PDZRN3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRGS12(3319778)-PDZRN3(73657835), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across RGS12 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PDZRN3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-E6-A8L9-01ARGS12chr4

3319778

-PDZRN3chr3

73657835

-
ChimerDB4UCECTCGA-E6-A8L9-01ARGS12chr4

3319778

+PDZRN3chr3

73657835

-


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Fusion Gene ORF analysis for RGS12-PDZRN3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000336727ENST00000308537RGS12chr4

3319778

+PDZRN3chr3

73657835

-
5CDS-intronENST00000336727ENST00000462146RGS12chr4

3319778

+PDZRN3chr3

73657835

-
5CDS-intronENST00000336727ENST00000466348RGS12chr4

3319778

+PDZRN3chr3

73657835

-
5CDS-intronENST00000336727ENST00000466780RGS12chr4

3319778

+PDZRN3chr3

73657835

-
5CDS-intronENST00000336727ENST00000479530RGS12chr4

3319778

+PDZRN3chr3

73657835

-
5CDS-intronENST00000336727ENST00000535920RGS12chr4

3319778

+PDZRN3chr3

73657835

-
5CDS-intronENST00000344733ENST00000308537RGS12chr4

3319778

+PDZRN3chr3

73657835

-
5CDS-intronENST00000344733ENST00000462146RGS12chr4

3319778

+PDZRN3chr3

73657835

-
5CDS-intronENST00000344733ENST00000466348RGS12chr4

3319778

+PDZRN3chr3

73657835

-
5CDS-intronENST00000344733ENST00000466780RGS12chr4

3319778

+PDZRN3chr3

73657835

-
5CDS-intronENST00000344733ENST00000479530RGS12chr4

3319778

+PDZRN3chr3

73657835

-
5CDS-intronENST00000344733ENST00000535920RGS12chr4

3319778

+PDZRN3chr3

73657835

-
5CDS-intronENST00000382788ENST00000308537RGS12chr4

3319778

+PDZRN3chr3

73657835

-
5CDS-intronENST00000382788ENST00000462146RGS12chr4

3319778

+PDZRN3chr3

73657835

-
5CDS-intronENST00000382788ENST00000466348RGS12chr4

3319778

+PDZRN3chr3

73657835

-
5CDS-intronENST00000382788ENST00000466780RGS12chr4

3319778

+PDZRN3chr3

73657835

-
5CDS-intronENST00000382788ENST00000479530RGS12chr4

3319778

+PDZRN3chr3

73657835

-
5CDS-intronENST00000382788ENST00000535920RGS12chr4

3319778

+PDZRN3chr3

73657835

-
5CDS-intronENST00000543385ENST00000308537RGS12chr4

3319778

+PDZRN3chr3

73657835

-
5CDS-intronENST00000543385ENST00000462146RGS12chr4

3319778

+PDZRN3chr3

73657835

-
5CDS-intronENST00000543385ENST00000466348RGS12chr4

3319778

+PDZRN3chr3

73657835

-
5CDS-intronENST00000543385ENST00000466780RGS12chr4

3319778

+PDZRN3chr3

73657835

-
5CDS-intronENST00000543385ENST00000479530RGS12chr4

3319778

+PDZRN3chr3

73657835

-
5CDS-intronENST00000543385ENST00000535920RGS12chr4

3319778

+PDZRN3chr3

73657835

-
In-frameENST00000336727ENST00000263666RGS12chr4

3319778

+PDZRN3chr3

73657835

-
In-frameENST00000344733ENST00000263666RGS12chr4

3319778

+PDZRN3chr3

73657835

-
In-frameENST00000382788ENST00000263666RGS12chr4

3319778

+PDZRN3chr3

73657835

-
In-frameENST00000543385ENST00000263666RGS12chr4

3319778

+PDZRN3chr3

73657835

-
intron-3CDSENST00000306648ENST00000263666RGS12chr4

3319778

+PDZRN3chr3

73657835

-
intron-3CDSENST00000338806ENST00000263666RGS12chr4

3319778

+PDZRN3chr3

73657835

-
intron-3CDSENST00000508158ENST00000263666RGS12chr4

3319778

+PDZRN3chr3

73657835

-
intron-3CDSENST00000538395ENST00000263666RGS12chr4

3319778

+PDZRN3chr3

73657835

-
intron-intronENST00000306648ENST00000308537RGS12chr4

3319778

+PDZRN3chr3

73657835

-
intron-intronENST00000306648ENST00000462146RGS12chr4

3319778

+PDZRN3chr3

73657835

-
intron-intronENST00000306648ENST00000466348RGS12chr4

3319778

+PDZRN3chr3

73657835

-
intron-intronENST00000306648ENST00000466780RGS12chr4

3319778

+PDZRN3chr3

73657835

-
intron-intronENST00000306648ENST00000479530RGS12chr4

3319778

+PDZRN3chr3

73657835

-
intron-intronENST00000306648ENST00000535920RGS12chr4

3319778

+PDZRN3chr3

73657835

-
intron-intronENST00000338806ENST00000308537RGS12chr4

3319778

+PDZRN3chr3

73657835

-
intron-intronENST00000338806ENST00000462146RGS12chr4

3319778

+PDZRN3chr3

73657835

-
intron-intronENST00000338806ENST00000466348RGS12chr4

3319778

+PDZRN3chr3

73657835

-
intron-intronENST00000338806ENST00000466780RGS12chr4

3319778

+PDZRN3chr3

73657835

-
intron-intronENST00000338806ENST00000479530RGS12chr4

3319778

+PDZRN3chr3

73657835

-
intron-intronENST00000338806ENST00000535920RGS12chr4

3319778

+PDZRN3chr3

73657835

-
intron-intronENST00000508158ENST00000308537RGS12chr4

3319778

+PDZRN3chr3

73657835

-
intron-intronENST00000508158ENST00000462146RGS12chr4

3319778

+PDZRN3chr3

73657835

-
intron-intronENST00000508158ENST00000466348RGS12chr4

3319778

+PDZRN3chr3

73657835

-
intron-intronENST00000508158ENST00000466780RGS12chr4

3319778

+PDZRN3chr3

73657835

-
intron-intronENST00000508158ENST00000479530RGS12chr4

3319778

+PDZRN3chr3

73657835

-
intron-intronENST00000508158ENST00000535920RGS12chr4

3319778

+PDZRN3chr3

73657835

-
intron-intronENST00000538395ENST00000308537RGS12chr4

3319778

+PDZRN3chr3

73657835

-
intron-intronENST00000538395ENST00000462146RGS12chr4

3319778

+PDZRN3chr3

73657835

-
intron-intronENST00000538395ENST00000466348RGS12chr4

3319778

+PDZRN3chr3

73657835

-
intron-intronENST00000538395ENST00000466780RGS12chr4

3319778

+PDZRN3chr3

73657835

-
intron-intronENST00000538395ENST00000479530RGS12chr4

3319778

+PDZRN3chr3

73657835

-
intron-intronENST00000538395ENST00000535920RGS12chr4

3319778

+PDZRN3chr3

73657835

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000543385RGS12chr43319778+ENST00000263666PDZRN3chr373657835-5447203715645141452
ENST00000336727RGS12chr43319778+ENST00000263666PDZRN3chr373657835-6195278590452621452
ENST00000344733RGS12chr43319778+ENST00000263666PDZRN3chr373657835-6195278590452621452
ENST00000382788RGS12chr43319778+ENST00000263666PDZRN3chr373657835-5394198410344611452

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000543385ENST00000263666RGS12chr43319778+PDZRN3chr373657835-0.0028216280.9971783
ENST00000336727ENST00000263666RGS12chr43319778+PDZRN3chr373657835-0.0038778070.9961222
ENST00000344733ENST00000263666RGS12chr43319778+PDZRN3chr373657835-0.0038778070.9961222
ENST00000382788ENST00000263666RGS12chr43319778+PDZRN3chr373657835-0.0026119020.99738806

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Fusion Genomic Features for RGS12-PDZRN3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RGS12-PDZRN3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:3319778/chr3:73657835)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRGS12chr4:3319778chr3:73657835ENST00000336727+217228_3406271377.0DomainPID
HgeneRGS12chr4:3319778chr3:73657835ENST00000336727+21722_986271377.0DomainPDZ
HgeneRGS12chr4:3319778chr3:73657835ENST00000344733+218228_3406271448.0DomainPID
HgeneRGS12chr4:3319778chr3:73657835ENST00000344733+21822_986271448.0DomainPDZ
HgeneRGS12chr4:3319778chr3:73657835ENST00000382788+116228_3406271377.0DomainPID
HgeneRGS12chr4:3319778chr3:73657835ENST00000382788+11622_986271377.0DomainPDZ
TgenePDZRN3chr4:3319778chr3:73657835ENST00000263666010679_7042411067.0Coiled coilOntology_term=ECO:0000255
TgenePDZRN3chr4:3319778chr3:73657835ENST00000263666010975_10252411067.0Coiled coilOntology_term=ECO:0000255
TgenePDZRN3chr4:3319778chr3:73657835ENST0000030853704679_704241361.0Coiled coilOntology_term=ECO:0000255
TgenePDZRN3chr4:3319778chr3:73657835ENST0000030853704975_1025241361.0Coiled coilOntology_term=ECO:0000255
TgenePDZRN3chr4:3319778chr3:73657835ENST00000263666010249_3392411067.0DomainPDZ 1
TgenePDZRN3chr4:3319778chr3:73657835ENST00000263666010419_5032411067.0DomainPDZ 2
TgenePDZRN3chr4:3319778chr3:73657835ENST0000030853704249_339241361.0DomainPDZ 1
TgenePDZRN3chr4:3319778chr3:73657835ENST0000030853704419_503241361.0DomainPDZ 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRGS12chr4:3319778chr3:73657835ENST00000306648+1151034_11040556.0DomainRBD 2
HgeneRGS12chr4:3319778chr3:73657835ENST00000306648+1151187_12090556.0DomainGoLoco
HgeneRGS12chr4:3319778chr3:73657835ENST00000306648+115228_3400556.0DomainPID
HgeneRGS12chr4:3319778chr3:73657835ENST00000306648+11522_980556.0DomainPDZ
HgeneRGS12chr4:3319778chr3:73657835ENST00000306648+115715_8320556.0DomainRGS
HgeneRGS12chr4:3319778chr3:73657835ENST00000306648+115962_10320556.0DomainRBD 1
HgeneRGS12chr4:3319778chr3:73657835ENST00000336727+2171034_11046271377.0DomainRBD 2
HgeneRGS12chr4:3319778chr3:73657835ENST00000336727+2171187_12096271377.0DomainGoLoco
HgeneRGS12chr4:3319778chr3:73657835ENST00000336727+217715_8326271377.0DomainRGS
HgeneRGS12chr4:3319778chr3:73657835ENST00000336727+217962_10326271377.0DomainRBD 1
HgeneRGS12chr4:3319778chr3:73657835ENST00000338806+1161034_11040800.0DomainRBD 2
HgeneRGS12chr4:3319778chr3:73657835ENST00000338806+1161187_12090800.0DomainGoLoco
HgeneRGS12chr4:3319778chr3:73657835ENST00000338806+116228_3400800.0DomainPID
HgeneRGS12chr4:3319778chr3:73657835ENST00000338806+11622_980800.0DomainPDZ
HgeneRGS12chr4:3319778chr3:73657835ENST00000338806+116715_8320800.0DomainRGS
HgeneRGS12chr4:3319778chr3:73657835ENST00000338806+116962_10320800.0DomainRBD 1
HgeneRGS12chr4:3319778chr3:73657835ENST00000344733+2181034_11046271448.0DomainRBD 2
HgeneRGS12chr4:3319778chr3:73657835ENST00000344733+2181187_12096271448.0DomainGoLoco
HgeneRGS12chr4:3319778chr3:73657835ENST00000344733+218715_8326271448.0DomainRGS
HgeneRGS12chr4:3319778chr3:73657835ENST00000344733+218962_10326271448.0DomainRBD 1
HgeneRGS12chr4:3319778chr3:73657835ENST00000382788+1161034_11046271377.0DomainRBD 2
HgeneRGS12chr4:3319778chr3:73657835ENST00000382788+1161187_12096271377.0DomainGoLoco
HgeneRGS12chr4:3319778chr3:73657835ENST00000382788+116715_8326271377.0DomainRGS
HgeneRGS12chr4:3319778chr3:73657835ENST00000382788+116962_10326271377.0DomainRBD 1
TgenePDZRN3chr4:3319778chr3:73657835ENST00000263666010100_1582411067.0Zinc fingerTRAF-type
TgenePDZRN3chr4:3319778chr3:73657835ENST0000026366601018_562411067.0Zinc fingerRING-type%3B degenerate
TgenePDZRN3chr4:3319778chr3:73657835ENST0000030853704100_158241361.0Zinc fingerTRAF-type
TgenePDZRN3chr4:3319778chr3:73657835ENST000003085370418_56241361.0Zinc fingerRING-type%3B degenerate


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Fusion Gene Sequence for RGS12-PDZRN3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>73799_73799_1_RGS12-PDZRN3_RGS12_chr4_3319778_ENST00000336727_PDZRN3_chr3_73657835_ENST00000263666_length(transcript)=6195nt_BP=2785nt
ATTTATATTCATTTTTTACTCTTTTCCATCAAAACATAATTTTACTAAGTACGCATGTTCTGTGTCCGTGTTTTGTCATCACTGAAGCCA
CTTTTGGAGTCACCTAGTAATAGCCTTTCCACTCTATCTAGTTCTGTAGCTTTTATGTGTGTAAATTACTTCAAATCTGTTTATGATCCT
ATTGCTGGAAACTTTATCCCAAGACACAAAAATCTTTTCTATTAGAAGTTATTAACTTTAAAACAATTATTTATTTTATTTTATTTTATT
TTTTGAGACAGAGTCTCGCTTTGTCACCCAGGCTGGAGTGCAGTGGCACGATCTCGGCTCACTGCAAGCTCCACCTCCCGAGTTCATGCC
ATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACGGGCGTCCGCCACCATGCCCAGCTAATTTTTTTTGTATTTTTGGTAGAGACAA
GGTTTCACCGTGTTAGCCAGGATGGTCTTGATCTCCTGACCTCGTGGTCCACCTGCCTCGGCCTCCCAAAGCGCTGGGATTATAGGCGTG
AGCCACCGCACCTGGCCTAAAACAATTATTTCTTTAAAAAAACATACCCTCTATTCTATTTTGTGTCTTCACAACACAATCACTTACTGT
ATTGCTTTTTAAAGTGATCTTTAAAGAGTCTTGCAGAAGAGACTACACAGCAGGCCCGAGACCATCCTGAGAGGCCTGTGTGCAAGGCTG
GCCCCCCGCTGGTGTCAGGACGGTGCCCACCACCCTCAATGAAGAGGGGCTCCCTGTGCTTAGCTGCTTGTGTGGGGAACAAGGGCACTG
TTTGAAGAAGCAAACATGGTAGCATCAAGCATTCCTTGAAATATGGCTCCAAGGGAACAATGAGACGTGCTCTTGGTCTTGGAAGCTCAT
CAGAATGTTTAGAGCTGGGGAGGCCTCCAAACGCCCATTGCCTGGGCCGTCGCCCCCAAGGGTGCGGAGTGTGGAGGTTGCCCGGGGGAG
GGCCGGCTACGGATTCACGCTTTCGGGACAGGCACCCTGTGTGCTCAGCTGCGTCATGAGAGGGAGCCCTGCGGATTTCGTGGGCCTCCG
AGCTGGAGACCAGATACTTGCTGTCAATGAAATCAACGTGAAAAAAGCATCTCATGAAGATGTAGTGAAATTAATTGGGAAGTGCTCTGG
TGTCCTTCACATGGTGATTGCTGAAGGCGTCGGCCGCTTCGAATCCTGTTCCAGTGATGAAGAAGGGGGACTCTATGAAGGAAAAGGCTG
GCTGAAGCCCAAGCTGGATTCTAAAGCACTAGGTATAAACAGAGCAGAGCGAGTCGTGGAGGAAATGCAGTCTGGTGGAATTTTCAATAT
GATTTTTGAAAACCCGAGCCTTTGTGCGAGCAATTCAGAGCCCTTGAAATTGAAACAAAGATCCCTTTCAGAGTCGGCCGCAACTCGATT
TGATGTTGGACATGAAAGTATAAATAATCCAAATCCCAACATGCTTTCTAAGGAGGAAATATCAAAAGTTATTCATGATGATTCGGTTTT
CAGCATTGGACTAGAAAGTCATGACGATTTTGCATTGGATGCAAGTATTTTAAACGTGGCGATGATCGTGGGCTACTTAGGCTCCATTGA
GCTTCCTTCCACGAGCTCCAACCTGGAGTCCGACAGCTTGCAAGCCATCCGCGGCTGCATGCGGCGCCTGCGGGCAGAGCAGAAAATCCA
CTCGCTGGTGACCATGAAGATCATGCACGACTGTGTGCAGCTGAGCACTGACAAGGCTGGAGTCGTGGCCGAGTACCCGGCCGAGAAGCT
GGCCTTCAGCGCCGTGTGCCCGGACGACCGGCGATTTTTCGGGTTGGTTACCATGCAGACGAATGACGACGGGAGCCTGGCCCAGGAGGA
GGAGGGCGCCCTGCGGACTTCCTGCCACGTGTTCATGGTGGACCCAGACTTGTTTAATCACAAGATCCACCAAGGCATTGCTCGGCGGTT
TGGGTTTGAGTGCACGGCCGACCCAGACACCAATGGCTGTCTGGAATTCCCGGCGTCCTCCCTCCCCGTCCTGCAGTTCATCTCTGTCCT
GTACCGAGACATGGGTGAGCTGATTGAGGGCATGCGGGCCCGCGCCTTTCTGGACGGGGACGCCGATGCCCACCAGAACAACAGCACCAG
CAGCAACAGTGACAGCGGCATTGGGAACTTCCACCAGGAGGAGAAGAGCAACCGGGTCCTTGTGGTGGACCTGGGTGGGAGCTCGAGCAG
ACACGGCCCCGGAGGCAGCGCGTGGGACGGTGTGGGTGGGAGGGGTGCCCAGCCCTGGGGTGCTCCCTGGACTGGGCCCTTCTGTCCGGA
CCCCGAAGGGAGCCCCCCATTTGAGGCCGCTCATCAGACTGACAGGTTCTGGGACCTAAACAAGCACCTAGGGCCAGCCTCTCCTGTGGA
GGTGCCCCCAGCTTCCTTGAGGAGCTCAGTCCCCCCTTCCAAGAGGGGCACCGTGGGTGCTGGCTGTGGTTTCAACCAGCGCTGGCTCCC
GGTCCACGTGCTCCGGGAGTGGCAGTGCGGACACACCAGCGACCAGGACTCTTACACAGATTCCACCGATGGCTGGTCCAGCATCAACTG
CGGCACACTGCCCCCTCCTATGAGCAAGATCCCCGCAGACCGCTACAGGGTGGAGGGCAGCTTCGCGCAGCCCCCGCTGAATGCCCCGAA
GAGGGAGTGGTCCAGGAAGGCCTTTGGAATGCAAAGCATTTTTGGTCCCCATCGAAATGTTCGAAAGACTAAGGAAGATAAAAAGGGCGA
AGAAACCAAAAGTCTGACTCTTGTCCTGCATCGGGACTCCGGCTCCCTGGGATTCAATATTATTGGTGGCCGGCCGAGTGTGGATAACCA
CGATGGATCATCCAGTGAAGGAATCTTTGTATCCAAGATAGTTGACAGTGGGCCTGCAGCCAAGGAAGGAGGCCTGCAAATTCATGACAG
GATTATTGAGGTCAACGGCAGAGACTTATCCAGAGCAACTCATGACCAGGCTGTGGAAGCTTTCAAGACAGCCAAGGAGCCCATAGTGGT
GCAGGTGTTGAGAAGAACACCAAGGACCAAAATGTTCACGCCTCCATCAGAGTCTCAGCTGGTGGACACGGGAACCCAAACCGACATCAC
CTTTGAACATATCATGGCCCTCACTAAGATGTCCTCTCCCAGCCCACCCGTGCTGGATCCCTATCTCTTGCCAGAGGAGCATCCCTCAGC
CCATGAATACTACGATCCAAATGACTACATTGGAGACATCCATCAGGAGATGGACAGGGAGGAGCTGGAGCTGGAGGAAGTGGACCTCTA
CAGAATGAACAGCCAGGACAAGCTGGGCCTCACTGTGTGCTACCGGACGGACGATGAAGACGACATTGGGATTTATATCAGTGAGATTGA
CCCTAACAGCATTGCAGCCAAGGATGGGCGCATCCGAGAAGGAGACCGCATTATCCAGATTAATGGGATAGAGGTGCAGAACCGTGAAGA
GGCTGTGGCTCTTCTAACCAGTGAAGAAAATAAAAACTTTTCATTGCTGATTGCAAGGCCTGAACTCCAGCTGGATGAGGGCTGGATGGA
TGATGACAGGAACGACTTTCTGGATGACCTGCACATGGACATGCTGGAGGAGCAGCACCACCAGGCCATGCAATTCACAGCTAGCGTGCT
GCAGCAGAAGAAGCACGACGAAGACGGTGGGACCACAGATACAGCCACCATCTTGTCCAACCAGCACGAGAAGGACAGCGGTGTGGGGCG
GACCGACGAGAGCACCCGTAATGACGAGAGCTCGGAGCAAGAGAACAATGGCGACGACGCCACCGCATCCTCCAACCCGCTGGCGGGGCA
GAGGAAGCTCACCTGCAGCCAGGACACCTTGGGCAGCGGCGACCTGCCCTTCAGCAACGAGTCTTTCATTTCGGCCGACTGCACGGACGC
CGACTACCTGGGGATCCCGGTGGACGAGTGCGAGCGCTTCCGCGAGCTCCTGGAGCTCAAGTGCCAGGTGAAGAGCGCCACCCCTTACGG
CCTGTACTACCCTAGCGGCCCCCTGGACGCCGGCAAGAGTGACCCTGAGAGCGTGGACAAGGAGCTGGAGCTGCTGAACGAAGAGCTGCG
CAGCATCGAGCTGGAGTGCCTGAGCATCGTGCGCGCCCACAAGATGCAGCAGCTCAAGGAGCAGTACCGCGAGTCCTGGATGCTGCACAA
CAGCGGCTTCCGCAACTACAACACCAGCATCGACGTGCGCAGACACGAGCTCTCAGATATCACCGAGCTCCCGGAGAAATCCGACAAGGA
CAGCTCGAGCGCCTACAACACAGGCGAGAGCTGCCGCAGCACCCCGCTCACCCTGGAGATCTCCCCCGACAACTCCTTGAGGAGAGCGGC
GGAGGGCATCAGCTGCCCGAGCAGCGAAGGGGCTGTGGGGACCACGGAAGCCTACGGGCCAGCCTCCAAGAATCTGCTCTCCATCACGGA
AGATCCCGAAGTGGGCACCCCTACCTATAGCCCGTCCCTGAAGGAGCTGGACCCCAACCAGCCCCTGGAAAGCAAAGAGCGGAGAGCCAG
CGACGGGAGCCGGAGCCCCACGCCCAGCCAGAAGCTGGGCAGCGCCTACCTGCCCTCCTATCACCACTCCCCATACAAGCACGCGCACAT
CCCGGCGCACGCCCAGCACTACCAGAGCTACATGCAGCTGATCCAGCAGAAGTCGGCCGTGGAGTACGCGCAAAGCCAGATGAGCCTGGT
GAGCATGTGCAAGGACCTGAGCTCTCCCACCCCGTCGGAGCCGCGCATGGAGTGGAAGGTGAAGATCCGCAGCGACGGGACGCGCTACAT
CACCAAGAGGCCCGTGCGGGACCGCCTGCTGCGGGAGCGCGCCCTGAAGATCCGGGAAGAGCGCAGCGGCATGACCACCGACGACGACGC
GGTGAGCGAGATGAAGATGGGGCGCTACTGGAGCAAGGAGGAGAGGAAGCAGCACCTGGTGAAGGCCAAGGAGCAGCGGCGGCGGCGCGA
GTTCATGATGCAGAGCAGGTTGGATTGTCTCAAGGAGCAGCAAGCAGCCGATGACAGGAAGGAGATGAACATTCTCGAACTGAGCCACAA
AAAGATGATGAAGAAGAGGAATAAGAAAATCTTCGATAACTGGATGACGATCCAAGAACTCTTAACCCACGGCACAAAATCCCCGGACGG
CACTAGAGTATACAATTCCTTCCTATCGGTGACTACTGTATAATTTTCACTTCTGCATTATGTACATAAAGGAGACCACTACCACTGGGG
TAGAAATTCCTGCCTCGTTCAATGCGGCAAGTTTTTGTATATAAGATAAGTACGGTCTTCATGTTTATAGTCCAAATTTGCAAACCCTAC
AACTCTGGGTGTCATAGGTCTATTTTAAGGGAAGAGAGAGAAAAACACCCTTACTATCTTGGAAGGCAATATTAACAAACAGAGCTTTTT
TCAAATAGCAATTGTACTTTTCTACCTGTACCCTTTTACATAAAGTGTTTAAATTTCAGAAAGATCTTTTATTAAGCATACTTTCACAGA
ATAACTTGTTTAAACTATATTCATATAAAAAAGTTAAACACGCTTTTTTTCCTGCCTAAAACACAAATACAACTGCCAGTATGTATTTTT
AATGGAACCCTATTTTATAATGGTACGTTACTGAATGTGTTTCATATGCGTGACCGTTAAGATATTATCATTTAGGTGAAGGTTTCAACT
CAAAACCACCCAACCCGGTGGTTAACGATTTAATACATATAACCAAACCGGCAGCGTTTAGAGTTGGGATATACATTTAAACATTTTCCT
GGTTAAGGTTCCCAAGAGAGTGTAAAGGTTTTAGCAGAAAGCAAAATATCTTGCATCTTTATGGAAGTTTAAAGCATGTTTGCAAATATT
GCAGCCCATTGAAAGAATTTGCATGTACAGGAAAGTTGTGGATGGAGACGGTTTGTGGAATTTTAAGTGCTCATTGTAGTAAACTTTTGC
TTTGTAGATTTGAAGGTACAGACTTATACAGGCAAGTTCACAAAATCATGATTAGTTACAAACAGTAAAATGAAGTTAAAATAAATTATT

>73799_73799_1_RGS12-PDZRN3_RGS12_chr4_3319778_ENST00000336727_PDZRN3_chr3_73657835_ENST00000263666_length(amino acids)=1452AA_BP=627
MFRAGEASKRPLPGPSPPRVRSVEVARGRAGYGFTLSGQAPCVLSCVMRGSPADFVGLRAGDQILAVNEINVKKASHEDVVKLIGKCSGV
LHMVIAEGVGRFESCSSDEEGGLYEGKGWLKPKLDSKALGINRAERVVEEMQSGGIFNMIFENPSLCASNSEPLKLKQRSLSESAATRFD
VGHESINNPNPNMLSKEEISKVIHDDSVFSIGLESHDDFALDASILNVAMIVGYLGSIELPSTSSNLESDSLQAIRGCMRRLRAEQKIHS
LVTMKIMHDCVQLSTDKAGVVAEYPAEKLAFSAVCPDDRRFFGLVTMQTNDDGSLAQEEEGALRTSCHVFMVDPDLFNHKIHQGIARRFG
FECTADPDTNGCLEFPASSLPVLQFISVLYRDMGELIEGMRARAFLDGDADAHQNNSTSSNSDSGIGNFHQEEKSNRVLVVDLGGSSSRH
GPGGSAWDGVGGRGAQPWGAPWTGPFCPDPEGSPPFEAAHQTDRFWDLNKHLGPASPVEVPPASLRSSVPPSKRGTVGAGCGFNQRWLPV
HVLREWQCGHTSDQDSYTDSTDGWSSINCGTLPPPMSKIPADRYRVEGSFAQPPLNAPKREWSRKAFGMQSIFGPHRNVRKTKEDKKGEE
TKSLTLVLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNGRDLSRATHDQAVEAFKTAKEPIVVQ
VLRRTPRTKMFTPPSESQLVDTGTQTDITFEHIMALTKMSSPSPPVLDPYLLPEEHPSAHEYYDPNDYIGDIHQEMDREELELEEVDLYR
MNSQDKLGLTVCYRTDDEDDIGIYISEIDPNSIAAKDGRIREGDRIIQINGIEVQNREEAVALLTSEENKNFSLLIARPELQLDEGWMDD
DRNDFLDDLHMDMLEEQHHQAMQFTASVLQQKKHDEDGGTTDTATILSNQHEKDSGVGRTDESTRNDESSEQENNGDDATASSNPLAGQR
KLTCSQDTLGSGDLPFSNESFISADCTDADYLGIPVDECERFRELLELKCQVKSATPYGLYYPSGPLDAGKSDPESVDKELELLNEELRS
IELECLSIVRAHKMQQLKEQYRESWMLHNSGFRNYNTSIDVRRHELSDITELPEKSDKDSSSAYNTGESCRSTPLTLEISPDNSLRRAAE
GISCPSSEGAVGTTEAYGPASKNLLSITEDPEVGTPTYSPSLKELDPNQPLESKERRASDGSRSPTPSQKLGSAYLPSYHHSPYKHAHIP
AHAQHYQSYMQLIQQKSAVEYAQSQMSLVSMCKDLSSPTPSEPRMEWKVKIRSDGTRYITKRPVRDRLLRERALKIREERSGMTTDDDAV
SEMKMGRYWSKEERKQHLVKAKEQRRRREFMMQSRLDCLKEQQAADDRKEMNILELSHKKMMKKRNKKIFDNWMTIQELLTHGTKSPDGT

--------------------------------------------------------------
>73799_73799_2_RGS12-PDZRN3_RGS12_chr4_3319778_ENST00000344733_PDZRN3_chr3_73657835_ENST00000263666_length(transcript)=6195nt_BP=2785nt
ATTTATATTCATTTTTTACTCTTTTCCATCAAAACATAATTTTACTAAGTACGCATGTTCTGTGTCCGTGTTTTGTCATCACTGAAGCCA
CTTTTGGAGTCACCTAGTAATAGCCTTTCCACTCTATCTAGTTCTGTAGCTTTTATGTGTGTAAATTACTTCAAATCTGTTTATGATCCT
ATTGCTGGAAACTTTATCCCAAGACACAAAAATCTTTTCTATTAGAAGTTATTAACTTTAAAACAATTATTTATTTTATTTTATTTTATT
TTTTGAGACAGAGTCTCGCTTTGTCACCCAGGCTGGAGTGCAGTGGCACGATCTCGGCTCACTGCAAGCTCCACCTCCCGAGTTCATGCC
ATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACGGGCGTCCGCCACCATGCCCAGCTAATTTTTTTTGTATTTTTGGTAGAGACAA
GGTTTCACCGTGTTAGCCAGGATGGTCTTGATCTCCTGACCTCGTGGTCCACCTGCCTCGGCCTCCCAAAGCGCTGGGATTATAGGCGTG
AGCCACCGCACCTGGCCTAAAACAATTATTTCTTTAAAAAAACATACCCTCTATTCTATTTTGTGTCTTCACAACACAATCACTTACTGT
ATTGCTTTTTAAAGTGATCTTTAAAGAGTCTTGCAGAAGAGACTACACAGCAGGCCCGAGACCATCCTGAGAGGCCTGTGTGCAAGGCTG
GCCCCCCGCTGGTGTCAGGACGGTGCCCACCACCCTCAATGAAGAGGGGCTCCCTGTGCTTAGCTGCTTGTGTGGGGAACAAGGGCACTG
TTTGAAGAAGCAAACATGGTAGCATCAAGCATTCCTTGAAATATGGCTCCAAGGGAACAATGAGACGTGCTCTTGGTCTTGGAAGCTCAT
CAGAATGTTTAGAGCTGGGGAGGCCTCCAAACGCCCATTGCCTGGGCCGTCGCCCCCAAGGGTGCGGAGTGTGGAGGTTGCCCGGGGGAG
GGCCGGCTACGGATTCACGCTTTCGGGACAGGCACCCTGTGTGCTCAGCTGCGTCATGAGAGGGAGCCCTGCGGATTTCGTGGGCCTCCG
AGCTGGAGACCAGATACTTGCTGTCAATGAAATCAACGTGAAAAAAGCATCTCATGAAGATGTAGTGAAATTAATTGGGAAGTGCTCTGG
TGTCCTTCACATGGTGATTGCTGAAGGCGTCGGCCGCTTCGAATCCTGTTCCAGTGATGAAGAAGGGGGACTCTATGAAGGAAAAGGCTG
GCTGAAGCCCAAGCTGGATTCTAAAGCACTAGGTATAAACAGAGCAGAGCGAGTCGTGGAGGAAATGCAGTCTGGTGGAATTTTCAATAT
GATTTTTGAAAACCCGAGCCTTTGTGCGAGCAATTCAGAGCCCTTGAAATTGAAACAAAGATCCCTTTCAGAGTCGGCCGCAACTCGATT
TGATGTTGGACATGAAAGTATAAATAATCCAAATCCCAACATGCTTTCTAAGGAGGAAATATCAAAAGTTATTCATGATGATTCGGTTTT
CAGCATTGGACTAGAAAGTCATGACGATTTTGCATTGGATGCAAGTATTTTAAACGTGGCGATGATCGTGGGCTACTTAGGCTCCATTGA
GCTTCCTTCCACGAGCTCCAACCTGGAGTCCGACAGCTTGCAAGCCATCCGCGGCTGCATGCGGCGCCTGCGGGCAGAGCAGAAAATCCA
CTCGCTGGTGACCATGAAGATCATGCACGACTGTGTGCAGCTGAGCACTGACAAGGCTGGAGTCGTGGCCGAGTACCCGGCCGAGAAGCT
GGCCTTCAGCGCCGTGTGCCCGGACGACCGGCGATTTTTCGGGTTGGTTACCATGCAGACGAATGACGACGGGAGCCTGGCCCAGGAGGA
GGAGGGCGCCCTGCGGACTTCCTGCCACGTGTTCATGGTGGACCCAGACTTGTTTAATCACAAGATCCACCAAGGCATTGCTCGGCGGTT
TGGGTTTGAGTGCACGGCCGACCCAGACACCAATGGCTGTCTGGAATTCCCGGCGTCCTCCCTCCCCGTCCTGCAGTTCATCTCTGTCCT
GTACCGAGACATGGGTGAGCTGATTGAGGGCATGCGGGCCCGCGCCTTTCTGGACGGGGACGCCGATGCCCACCAGAACAACAGCACCAG
CAGCAACAGTGACAGCGGCATTGGGAACTTCCACCAGGAGGAGAAGAGCAACCGGGTCCTTGTGGTGGACCTGGGTGGGAGCTCGAGCAG
ACACGGCCCCGGAGGCAGCGCGTGGGACGGTGTGGGTGGGAGGGGTGCCCAGCCCTGGGGTGCTCCCTGGACTGGGCCCTTCTGTCCGGA
CCCCGAAGGGAGCCCCCCATTTGAGGCCGCTCATCAGACTGACAGGTTCTGGGACCTAAACAAGCACCTAGGGCCAGCCTCTCCTGTGGA
GGTGCCCCCAGCTTCCTTGAGGAGCTCAGTCCCCCCTTCCAAGAGGGGCACCGTGGGTGCTGGCTGTGGTTTCAACCAGCGCTGGCTCCC
GGTCCACGTGCTCCGGGAGTGGCAGTGCGGACACACCAGCGACCAGGACTCTTACACAGATTCCACCGATGGCTGGTCCAGCATCAACTG
CGGCACACTGCCCCCTCCTATGAGCAAGATCCCCGCAGACCGCTACAGGGTGGAGGGCAGCTTCGCGCAGCCCCCGCTGAATGCCCCGAA
GAGGGAGTGGTCCAGGAAGGCCTTTGGAATGCAAAGCATTTTTGGTCCCCATCGAAATGTTCGAAAGACTAAGGAAGATAAAAAGGGCGA
AGAAACCAAAAGTCTGACTCTTGTCCTGCATCGGGACTCCGGCTCCCTGGGATTCAATATTATTGGTGGCCGGCCGAGTGTGGATAACCA
CGATGGATCATCCAGTGAAGGAATCTTTGTATCCAAGATAGTTGACAGTGGGCCTGCAGCCAAGGAAGGAGGCCTGCAAATTCATGACAG
GATTATTGAGGTCAACGGCAGAGACTTATCCAGAGCAACTCATGACCAGGCTGTGGAAGCTTTCAAGACAGCCAAGGAGCCCATAGTGGT
GCAGGTGTTGAGAAGAACACCAAGGACCAAAATGTTCACGCCTCCATCAGAGTCTCAGCTGGTGGACACGGGAACCCAAACCGACATCAC
CTTTGAACATATCATGGCCCTCACTAAGATGTCCTCTCCCAGCCCACCCGTGCTGGATCCCTATCTCTTGCCAGAGGAGCATCCCTCAGC
CCATGAATACTACGATCCAAATGACTACATTGGAGACATCCATCAGGAGATGGACAGGGAGGAGCTGGAGCTGGAGGAAGTGGACCTCTA
CAGAATGAACAGCCAGGACAAGCTGGGCCTCACTGTGTGCTACCGGACGGACGATGAAGACGACATTGGGATTTATATCAGTGAGATTGA
CCCTAACAGCATTGCAGCCAAGGATGGGCGCATCCGAGAAGGAGACCGCATTATCCAGATTAATGGGATAGAGGTGCAGAACCGTGAAGA
GGCTGTGGCTCTTCTAACCAGTGAAGAAAATAAAAACTTTTCATTGCTGATTGCAAGGCCTGAACTCCAGCTGGATGAGGGCTGGATGGA
TGATGACAGGAACGACTTTCTGGATGACCTGCACATGGACATGCTGGAGGAGCAGCACCACCAGGCCATGCAATTCACAGCTAGCGTGCT
GCAGCAGAAGAAGCACGACGAAGACGGTGGGACCACAGATACAGCCACCATCTTGTCCAACCAGCACGAGAAGGACAGCGGTGTGGGGCG
GACCGACGAGAGCACCCGTAATGACGAGAGCTCGGAGCAAGAGAACAATGGCGACGACGCCACCGCATCCTCCAACCCGCTGGCGGGGCA
GAGGAAGCTCACCTGCAGCCAGGACACCTTGGGCAGCGGCGACCTGCCCTTCAGCAACGAGTCTTTCATTTCGGCCGACTGCACGGACGC
CGACTACCTGGGGATCCCGGTGGACGAGTGCGAGCGCTTCCGCGAGCTCCTGGAGCTCAAGTGCCAGGTGAAGAGCGCCACCCCTTACGG
CCTGTACTACCCTAGCGGCCCCCTGGACGCCGGCAAGAGTGACCCTGAGAGCGTGGACAAGGAGCTGGAGCTGCTGAACGAAGAGCTGCG
CAGCATCGAGCTGGAGTGCCTGAGCATCGTGCGCGCCCACAAGATGCAGCAGCTCAAGGAGCAGTACCGCGAGTCCTGGATGCTGCACAA
CAGCGGCTTCCGCAACTACAACACCAGCATCGACGTGCGCAGACACGAGCTCTCAGATATCACCGAGCTCCCGGAGAAATCCGACAAGGA
CAGCTCGAGCGCCTACAACACAGGCGAGAGCTGCCGCAGCACCCCGCTCACCCTGGAGATCTCCCCCGACAACTCCTTGAGGAGAGCGGC
GGAGGGCATCAGCTGCCCGAGCAGCGAAGGGGCTGTGGGGACCACGGAAGCCTACGGGCCAGCCTCCAAGAATCTGCTCTCCATCACGGA
AGATCCCGAAGTGGGCACCCCTACCTATAGCCCGTCCCTGAAGGAGCTGGACCCCAACCAGCCCCTGGAAAGCAAAGAGCGGAGAGCCAG
CGACGGGAGCCGGAGCCCCACGCCCAGCCAGAAGCTGGGCAGCGCCTACCTGCCCTCCTATCACCACTCCCCATACAAGCACGCGCACAT
CCCGGCGCACGCCCAGCACTACCAGAGCTACATGCAGCTGATCCAGCAGAAGTCGGCCGTGGAGTACGCGCAAAGCCAGATGAGCCTGGT
GAGCATGTGCAAGGACCTGAGCTCTCCCACCCCGTCGGAGCCGCGCATGGAGTGGAAGGTGAAGATCCGCAGCGACGGGACGCGCTACAT
CACCAAGAGGCCCGTGCGGGACCGCCTGCTGCGGGAGCGCGCCCTGAAGATCCGGGAAGAGCGCAGCGGCATGACCACCGACGACGACGC
GGTGAGCGAGATGAAGATGGGGCGCTACTGGAGCAAGGAGGAGAGGAAGCAGCACCTGGTGAAGGCCAAGGAGCAGCGGCGGCGGCGCGA
GTTCATGATGCAGAGCAGGTTGGATTGTCTCAAGGAGCAGCAAGCAGCCGATGACAGGAAGGAGATGAACATTCTCGAACTGAGCCACAA
AAAGATGATGAAGAAGAGGAATAAGAAAATCTTCGATAACTGGATGACGATCCAAGAACTCTTAACCCACGGCACAAAATCCCCGGACGG
CACTAGAGTATACAATTCCTTCCTATCGGTGACTACTGTATAATTTTCACTTCTGCATTATGTACATAAAGGAGACCACTACCACTGGGG
TAGAAATTCCTGCCTCGTTCAATGCGGCAAGTTTTTGTATATAAGATAAGTACGGTCTTCATGTTTATAGTCCAAATTTGCAAACCCTAC
AACTCTGGGTGTCATAGGTCTATTTTAAGGGAAGAGAGAGAAAAACACCCTTACTATCTTGGAAGGCAATATTAACAAACAGAGCTTTTT
TCAAATAGCAATTGTACTTTTCTACCTGTACCCTTTTACATAAAGTGTTTAAATTTCAGAAAGATCTTTTATTAAGCATACTTTCACAGA
ATAACTTGTTTAAACTATATTCATATAAAAAAGTTAAACACGCTTTTTTTCCTGCCTAAAACACAAATACAACTGCCAGTATGTATTTTT
AATGGAACCCTATTTTATAATGGTACGTTACTGAATGTGTTTCATATGCGTGACCGTTAAGATATTATCATTTAGGTGAAGGTTTCAACT
CAAAACCACCCAACCCGGTGGTTAACGATTTAATACATATAACCAAACCGGCAGCGTTTAGAGTTGGGATATACATTTAAACATTTTCCT
GGTTAAGGTTCCCAAGAGAGTGTAAAGGTTTTAGCAGAAAGCAAAATATCTTGCATCTTTATGGAAGTTTAAAGCATGTTTGCAAATATT
GCAGCCCATTGAAAGAATTTGCATGTACAGGAAAGTTGTGGATGGAGACGGTTTGTGGAATTTTAAGTGCTCATTGTAGTAAACTTTTGC
TTTGTAGATTTGAAGGTACAGACTTATACAGGCAAGTTCACAAAATCATGATTAGTTACAAACAGTAAAATGAAGTTAAAATAAATTATT

>73799_73799_2_RGS12-PDZRN3_RGS12_chr4_3319778_ENST00000344733_PDZRN3_chr3_73657835_ENST00000263666_length(amino acids)=1452AA_BP=627
MFRAGEASKRPLPGPSPPRVRSVEVARGRAGYGFTLSGQAPCVLSCVMRGSPADFVGLRAGDQILAVNEINVKKASHEDVVKLIGKCSGV
LHMVIAEGVGRFESCSSDEEGGLYEGKGWLKPKLDSKALGINRAERVVEEMQSGGIFNMIFENPSLCASNSEPLKLKQRSLSESAATRFD
VGHESINNPNPNMLSKEEISKVIHDDSVFSIGLESHDDFALDASILNVAMIVGYLGSIELPSTSSNLESDSLQAIRGCMRRLRAEQKIHS
LVTMKIMHDCVQLSTDKAGVVAEYPAEKLAFSAVCPDDRRFFGLVTMQTNDDGSLAQEEEGALRTSCHVFMVDPDLFNHKIHQGIARRFG
FECTADPDTNGCLEFPASSLPVLQFISVLYRDMGELIEGMRARAFLDGDADAHQNNSTSSNSDSGIGNFHQEEKSNRVLVVDLGGSSSRH
GPGGSAWDGVGGRGAQPWGAPWTGPFCPDPEGSPPFEAAHQTDRFWDLNKHLGPASPVEVPPASLRSSVPPSKRGTVGAGCGFNQRWLPV
HVLREWQCGHTSDQDSYTDSTDGWSSINCGTLPPPMSKIPADRYRVEGSFAQPPLNAPKREWSRKAFGMQSIFGPHRNVRKTKEDKKGEE
TKSLTLVLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNGRDLSRATHDQAVEAFKTAKEPIVVQ
VLRRTPRTKMFTPPSESQLVDTGTQTDITFEHIMALTKMSSPSPPVLDPYLLPEEHPSAHEYYDPNDYIGDIHQEMDREELELEEVDLYR
MNSQDKLGLTVCYRTDDEDDIGIYISEIDPNSIAAKDGRIREGDRIIQINGIEVQNREEAVALLTSEENKNFSLLIARPELQLDEGWMDD
DRNDFLDDLHMDMLEEQHHQAMQFTASVLQQKKHDEDGGTTDTATILSNQHEKDSGVGRTDESTRNDESSEQENNGDDATASSNPLAGQR
KLTCSQDTLGSGDLPFSNESFISADCTDADYLGIPVDECERFRELLELKCQVKSATPYGLYYPSGPLDAGKSDPESVDKELELLNEELRS
IELECLSIVRAHKMQQLKEQYRESWMLHNSGFRNYNTSIDVRRHELSDITELPEKSDKDSSSAYNTGESCRSTPLTLEISPDNSLRRAAE
GISCPSSEGAVGTTEAYGPASKNLLSITEDPEVGTPTYSPSLKELDPNQPLESKERRASDGSRSPTPSQKLGSAYLPSYHHSPYKHAHIP
AHAQHYQSYMQLIQQKSAVEYAQSQMSLVSMCKDLSSPTPSEPRMEWKVKIRSDGTRYITKRPVRDRLLRERALKIREERSGMTTDDDAV
SEMKMGRYWSKEERKQHLVKAKEQRRRREFMMQSRLDCLKEQQAADDRKEMNILELSHKKMMKKRNKKIFDNWMTIQELLTHGTKSPDGT

--------------------------------------------------------------
>73799_73799_3_RGS12-PDZRN3_RGS12_chr4_3319778_ENST00000382788_PDZRN3_chr3_73657835_ENST00000263666_length(transcript)=5394nt_BP=1984nt
AGGGCACTGTTTGAAGAAGCAAACATGGTAGCATCAAGCATTCCTTGAAATATGGCTCCAAGGGAACAATGAGACGTGCTCTTGGTCTTG
GAAGCTCATCAGAATGTTTAGAGCTGGGGAGGCCTCCAAACGCCCATTGCCTGGGCCGTCGCCCCCAAGGGTGCGGAGTGTGGAGGTTGC
CCGGGGGAGGGCCGGCTACGGATTCACGCTTTCGGGACAGGCACCCTGTGTGCTCAGCTGCGTCATGAGAGGGAGCCCTGCGGATTTCGT
GGGCCTCCGAGCTGGAGACCAGATACTTGCTGTCAATGAAATCAACGTGAAAAAAGCATCTCATGAAGATGTAGTGAAATTAATTGGGAA
GTGCTCTGGTGTCCTTCACATGGTGATTGCTGAAGGCGTCGGCCGCTTCGAATCCTGTTCCAGTGATGAAGAAGGGGGACTCTATGAAGG
AAAAGGCTGGCTGAAGCCCAAGCTGGATTCTAAAGCACTAGGTATAAACAGAGCAGAGCGAGTCGTGGAGGAAATGCAGTCTGGTGGAAT
TTTCAATATGATTTTTGAAAACCCGAGCCTTTGTGCGAGCAATTCAGAGCCCTTGAAATTGAAACAAAGATCCCTTTCAGAGTCGGCCGC
AACTCGATTTGATGTTGGACATGAAAGTATAAATAATCCAAATCCCAACATGCTTTCTAAGGAGGAAATATCAAAAGTTATTCATGATGA
TTCGGTTTTCAGCATTGGACTAGAAAGTCATGACGATTTTGCATTGGATGCAAGTATTTTAAACGTGGCGATGATCGTGGGCTACTTAGG
CTCCATTGAGCTTCCTTCCACGAGCTCCAACCTGGAGTCCGACAGCTTGCAAGCCATCCGCGGCTGCATGCGGCGCCTGCGGGCAGAGCA
GAAAATCCACTCGCTGGTGACCATGAAGATCATGCACGACTGTGTGCAGCTGAGCACTGACAAGGCTGGAGTCGTGGCCGAGTACCCGGC
CGAGAAGCTGGCCTTCAGCGCCGTGTGCCCGGACGACCGGCGATTTTTCGGGTTGGTTACCATGCAGACGAATGACGACGGGAGCCTGGC
CCAGGAGGAGGAGGGCGCCCTGCGGACTTCCTGCCACGTGTTCATGGTGGACCCAGACTTGTTTAATCACAAGATCCACCAAGGCATTGC
TCGGCGGTTTGGGTTTGAGTGCACGGCCGACCCAGACACCAATGGCTGTCTGGAATTCCCGGCGTCCTCCCTCCCCGTCCTGCAGTTCAT
CTCTGTCCTGTACCGAGACATGGGTGAGCTGATTGAGGGCATGCGGGCCCGCGCCTTTCTGGACGGGGACGCCGATGCCCACCAGAACAA
CAGCACCAGCAGCAACAGTGACAGCGGCATTGGGAACTTCCACCAGGAGGAGAAGAGCAACCGGGTCCTTGTGGTGGACCTGGGTGGGAG
CTCGAGCAGACACGGCCCCGGAGGCAGCGCGTGGGACGGTGTGGGTGGGAGGGGTGCCCAGCCCTGGGGTGCTCCCTGGACTGGGCCCTT
CTGTCCGGACCCCGAAGGGAGCCCCCCATTTGAGGCCGCTCATCAGACTGACAGGTTCTGGGACCTAAACAAGCACCTAGGGCCAGCCTC
TCCTGTGGAGGTGCCCCCAGCTTCCTTGAGGAGCTCAGTCCCCCCTTCCAAGAGGGGCACCGTGGGTGCTGGCTGTGGTTTCAACCAGCG
CTGGCTCCCGGTCCACGTGCTCCGGGAGTGGCAGTGCGGACACACCAGCGACCAGGACTCTTACACAGATTCCACCGATGGCTGGTCCAG
CATCAACTGCGGCACACTGCCCCCTCCTATGAGCAAGATCCCCGCAGACCGCTACAGGGTGGAGGGCAGCTTCGCGCAGCCCCCGCTGAA
TGCCCCGAAGAGGGAGTGGTCCAGGAAGGCCTTTGGAATGCAAAGCATTTTTGGTCCCCATCGAAATGTTCGAAAGACTAAGGAAGATAA
AAAGGGCGAAGAAACCAAAAGTCTGACTCTTGTCCTGCATCGGGACTCCGGCTCCCTGGGATTCAATATTATTGGTGGCCGGCCGAGTGT
GGATAACCACGATGGATCATCCAGTGAAGGAATCTTTGTATCCAAGATAGTTGACAGTGGGCCTGCAGCCAAGGAAGGAGGCCTGCAAAT
TCATGACAGGATTATTGAGGTCAACGGCAGAGACTTATCCAGAGCAACTCATGACCAGGCTGTGGAAGCTTTCAAGACAGCCAAGGAGCC
CATAGTGGTGCAGGTGTTGAGAAGAACACCAAGGACCAAAATGTTCACGCCTCCATCAGAGTCTCAGCTGGTGGACACGGGAACCCAAAC
CGACATCACCTTTGAACATATCATGGCCCTCACTAAGATGTCCTCTCCCAGCCCACCCGTGCTGGATCCCTATCTCTTGCCAGAGGAGCA
TCCCTCAGCCCATGAATACTACGATCCAAATGACTACATTGGAGACATCCATCAGGAGATGGACAGGGAGGAGCTGGAGCTGGAGGAAGT
GGACCTCTACAGAATGAACAGCCAGGACAAGCTGGGCCTCACTGTGTGCTACCGGACGGACGATGAAGACGACATTGGGATTTATATCAG
TGAGATTGACCCTAACAGCATTGCAGCCAAGGATGGGCGCATCCGAGAAGGAGACCGCATTATCCAGATTAATGGGATAGAGGTGCAGAA
CCGTGAAGAGGCTGTGGCTCTTCTAACCAGTGAAGAAAATAAAAACTTTTCATTGCTGATTGCAAGGCCTGAACTCCAGCTGGATGAGGG
CTGGATGGATGATGACAGGAACGACTTTCTGGATGACCTGCACATGGACATGCTGGAGGAGCAGCACCACCAGGCCATGCAATTCACAGC
TAGCGTGCTGCAGCAGAAGAAGCACGACGAAGACGGTGGGACCACAGATACAGCCACCATCTTGTCCAACCAGCACGAGAAGGACAGCGG
TGTGGGGCGGACCGACGAGAGCACCCGTAATGACGAGAGCTCGGAGCAAGAGAACAATGGCGACGACGCCACCGCATCCTCCAACCCGCT
GGCGGGGCAGAGGAAGCTCACCTGCAGCCAGGACACCTTGGGCAGCGGCGACCTGCCCTTCAGCAACGAGTCTTTCATTTCGGCCGACTG
CACGGACGCCGACTACCTGGGGATCCCGGTGGACGAGTGCGAGCGCTTCCGCGAGCTCCTGGAGCTCAAGTGCCAGGTGAAGAGCGCCAC
CCCTTACGGCCTGTACTACCCTAGCGGCCCCCTGGACGCCGGCAAGAGTGACCCTGAGAGCGTGGACAAGGAGCTGGAGCTGCTGAACGA
AGAGCTGCGCAGCATCGAGCTGGAGTGCCTGAGCATCGTGCGCGCCCACAAGATGCAGCAGCTCAAGGAGCAGTACCGCGAGTCCTGGAT
GCTGCACAACAGCGGCTTCCGCAACTACAACACCAGCATCGACGTGCGCAGACACGAGCTCTCAGATATCACCGAGCTCCCGGAGAAATC
CGACAAGGACAGCTCGAGCGCCTACAACACAGGCGAGAGCTGCCGCAGCACCCCGCTCACCCTGGAGATCTCCCCCGACAACTCCTTGAG
GAGAGCGGCGGAGGGCATCAGCTGCCCGAGCAGCGAAGGGGCTGTGGGGACCACGGAAGCCTACGGGCCAGCCTCCAAGAATCTGCTCTC
CATCACGGAAGATCCCGAAGTGGGCACCCCTACCTATAGCCCGTCCCTGAAGGAGCTGGACCCCAACCAGCCCCTGGAAAGCAAAGAGCG
GAGAGCCAGCGACGGGAGCCGGAGCCCCACGCCCAGCCAGAAGCTGGGCAGCGCCTACCTGCCCTCCTATCACCACTCCCCATACAAGCA
CGCGCACATCCCGGCGCACGCCCAGCACTACCAGAGCTACATGCAGCTGATCCAGCAGAAGTCGGCCGTGGAGTACGCGCAAAGCCAGAT
GAGCCTGGTGAGCATGTGCAAGGACCTGAGCTCTCCCACCCCGTCGGAGCCGCGCATGGAGTGGAAGGTGAAGATCCGCAGCGACGGGAC
GCGCTACATCACCAAGAGGCCCGTGCGGGACCGCCTGCTGCGGGAGCGCGCCCTGAAGATCCGGGAAGAGCGCAGCGGCATGACCACCGA
CGACGACGCGGTGAGCGAGATGAAGATGGGGCGCTACTGGAGCAAGGAGGAGAGGAAGCAGCACCTGGTGAAGGCCAAGGAGCAGCGGCG
GCGGCGCGAGTTCATGATGCAGAGCAGGTTGGATTGTCTCAAGGAGCAGCAAGCAGCCGATGACAGGAAGGAGATGAACATTCTCGAACT
GAGCCACAAAAAGATGATGAAGAAGAGGAATAAGAAAATCTTCGATAACTGGATGACGATCCAAGAACTCTTAACCCACGGCACAAAATC
CCCGGACGGCACTAGAGTATACAATTCCTTCCTATCGGTGACTACTGTATAATTTTCACTTCTGCATTATGTACATAAAGGAGACCACTA
CCACTGGGGTAGAAATTCCTGCCTCGTTCAATGCGGCAAGTTTTTGTATATAAGATAAGTACGGTCTTCATGTTTATAGTCCAAATTTGC
AAACCCTACAACTCTGGGTGTCATAGGTCTATTTTAAGGGAAGAGAGAGAAAAACACCCTTACTATCTTGGAAGGCAATATTAACAAACA
GAGCTTTTTTCAAATAGCAATTGTACTTTTCTACCTGTACCCTTTTACATAAAGTGTTTAAATTTCAGAAAGATCTTTTATTAAGCATAC
TTTCACAGAATAACTTGTTTAAACTATATTCATATAAAAAAGTTAAACACGCTTTTTTTCCTGCCTAAAACACAAATACAACTGCCAGTA
TGTATTTTTAATGGAACCCTATTTTATAATGGTACGTTACTGAATGTGTTTCATATGCGTGACCGTTAAGATATTATCATTTAGGTGAAG
GTTTCAACTCAAAACCACCCAACCCGGTGGTTAACGATTTAATACATATAACCAAACCGGCAGCGTTTAGAGTTGGGATATACATTTAAA
CATTTTCCTGGTTAAGGTTCCCAAGAGAGTGTAAAGGTTTTAGCAGAAAGCAAAATATCTTGCATCTTTATGGAAGTTTAAAGCATGTTT
GCAAATATTGCAGCCCATTGAAAGAATTTGCATGTACAGGAAAGTTGTGGATGGAGACGGTTTGTGGAATTTTAAGTGCTCATTGTAGTA
AACTTTTGCTTTGTAGATTTGAAGGTACAGACTTATACAGGCAAGTTCACAAAATCATGATTAGTTACAAACAGTAAAATGAAGTTAAAA

>73799_73799_3_RGS12-PDZRN3_RGS12_chr4_3319778_ENST00000382788_PDZRN3_chr3_73657835_ENST00000263666_length(amino acids)=1452AA_BP=627
MFRAGEASKRPLPGPSPPRVRSVEVARGRAGYGFTLSGQAPCVLSCVMRGSPADFVGLRAGDQILAVNEINVKKASHEDVVKLIGKCSGV
LHMVIAEGVGRFESCSSDEEGGLYEGKGWLKPKLDSKALGINRAERVVEEMQSGGIFNMIFENPSLCASNSEPLKLKQRSLSESAATRFD
VGHESINNPNPNMLSKEEISKVIHDDSVFSIGLESHDDFALDASILNVAMIVGYLGSIELPSTSSNLESDSLQAIRGCMRRLRAEQKIHS
LVTMKIMHDCVQLSTDKAGVVAEYPAEKLAFSAVCPDDRRFFGLVTMQTNDDGSLAQEEEGALRTSCHVFMVDPDLFNHKIHQGIARRFG
FECTADPDTNGCLEFPASSLPVLQFISVLYRDMGELIEGMRARAFLDGDADAHQNNSTSSNSDSGIGNFHQEEKSNRVLVVDLGGSSSRH
GPGGSAWDGVGGRGAQPWGAPWTGPFCPDPEGSPPFEAAHQTDRFWDLNKHLGPASPVEVPPASLRSSVPPSKRGTVGAGCGFNQRWLPV
HVLREWQCGHTSDQDSYTDSTDGWSSINCGTLPPPMSKIPADRYRVEGSFAQPPLNAPKREWSRKAFGMQSIFGPHRNVRKTKEDKKGEE
TKSLTLVLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNGRDLSRATHDQAVEAFKTAKEPIVVQ
VLRRTPRTKMFTPPSESQLVDTGTQTDITFEHIMALTKMSSPSPPVLDPYLLPEEHPSAHEYYDPNDYIGDIHQEMDREELELEEVDLYR
MNSQDKLGLTVCYRTDDEDDIGIYISEIDPNSIAAKDGRIREGDRIIQINGIEVQNREEAVALLTSEENKNFSLLIARPELQLDEGWMDD
DRNDFLDDLHMDMLEEQHHQAMQFTASVLQQKKHDEDGGTTDTATILSNQHEKDSGVGRTDESTRNDESSEQENNGDDATASSNPLAGQR
KLTCSQDTLGSGDLPFSNESFISADCTDADYLGIPVDECERFRELLELKCQVKSATPYGLYYPSGPLDAGKSDPESVDKELELLNEELRS
IELECLSIVRAHKMQQLKEQYRESWMLHNSGFRNYNTSIDVRRHELSDITELPEKSDKDSSSAYNTGESCRSTPLTLEISPDNSLRRAAE
GISCPSSEGAVGTTEAYGPASKNLLSITEDPEVGTPTYSPSLKELDPNQPLESKERRASDGSRSPTPSQKLGSAYLPSYHHSPYKHAHIP
AHAQHYQSYMQLIQQKSAVEYAQSQMSLVSMCKDLSSPTPSEPRMEWKVKIRSDGTRYITKRPVRDRLLRERALKIREERSGMTTDDDAV
SEMKMGRYWSKEERKQHLVKAKEQRRRREFMMQSRLDCLKEQQAADDRKEMNILELSHKKMMKKRNKKIFDNWMTIQELLTHGTKSPDGT

--------------------------------------------------------------
>73799_73799_4_RGS12-PDZRN3_RGS12_chr4_3319778_ENST00000543385_PDZRN3_chr3_73657835_ENST00000263666_length(transcript)=5447nt_BP=2037nt
AGGTGTCCTCTGAGGAGAGCTGAGCAGGAGAGGAGCTGGGACTCGGGAATGGCAGGGCACTGTTTGAAGAAGCAAACATGGTAGCATCAA
GCATTCCTTGAAATATGGCTCCAAGGGAACAATGAGACGTGCTCTTGGTCTTGGAAGCTCATCAGAATGTTTAGAGCTGGGGAGGCCTCC
AAACGCCCATTGCCTGGGCCGTCGCCCCCAAGGGTGCGGAGTGTGGAGGTTGCCCGGGGGAGGGCCGGCTACGGATTCACGCTTTCGGGA
CAGGCACCCTGTGTGCTCAGCTGCGTCATGAGAGGGAGCCCTGCGGATTTCGTGGGCCTCCGAGCTGGAGACCAGATACTTGCTGTCAAT
GAAATCAACGTGAAAAAAGCATCTCATGAAGATGTAGTGAAATTAATTGGGAAGTGCTCTGGTGTCCTTCACATGGTGATTGCTGAAGGC
GTCGGCCGCTTCGAATCCTGTTCCAGTGATGAAGAAGGGGGACTCTATGAAGGAAAAGGCTGGCTGAAGCCCAAGCTGGATTCTAAAGCA
CTAGGTATAAACAGAGCAGAGCGAGTCGTGGAGGAAATGCAGTCTGGTGGAATTTTCAATATGATTTTTGAAAACCCGAGCCTTTGTGCG
AGCAATTCAGAGCCCTTGAAATTGAAACAAAGATCCCTTTCAGAGTCGGCCGCAACTCGATTTGATGTTGGACATGAAAGTATAAATAAT
CCAAATCCCAACATGCTTTCTAAGGAGGAAATATCAAAAGTTATTCATGATGATTCGGTTTTCAGCATTGGACTAGAAAGTCATGACGAT
TTTGCATTGGATGCAAGTATTTTAAACGTGGCGATGATCGTGGGCTACTTAGGCTCCATTGAGCTTCCTTCCACGAGCTCCAACCTGGAG
TCCGACAGCTTGCAAGCCATCCGCGGCTGCATGCGGCGCCTGCGGGCAGAGCAGAAAATCCACTCGCTGGTGACCATGAAGATCATGCAC
GACTGTGTGCAGCTGAGCACTGACAAGGCTGGAGTCGTGGCCGAGTACCCGGCCGAGAAGCTGGCCTTCAGCGCCGTGTGCCCGGACGAC
CGGCGATTTTTCGGGTTGGTTACCATGCAGACGAATGACGACGGGAGCCTGGCCCAGGAGGAGGAGGGCGCCCTGCGGACTTCCTGCCAC
GTGTTCATGGTGGACCCAGACTTGTTTAATCACAAGATCCACCAAGGCATTGCTCGGCGGTTTGGGTTTGAGTGCACGGCCGACCCAGAC
ACCAATGGCTGTCTGGAATTCCCGGCGTCCTCCCTCCCCGTCCTGCAGTTCATCTCTGTCCTGTACCGAGACATGGGTGAGCTGATTGAG
GGCATGCGGGCCCGCGCCTTTCTGGACGGGGACGCCGATGCCCACCAGAACAACAGCACCAGCAGCAACAGTGACAGCGGCATTGGGAAC
TTCCACCAGGAGGAGAAGAGCAACCGGGTCCTTGTGGTGGACCTGGGTGGGAGCTCGAGCAGACACGGCCCCGGAGGCAGCGCGTGGGAC
GGTGTGGGTGGGAGGGGTGCCCAGCCCTGGGGTGCTCCCTGGACTGGGCCCTTCTGTCCGGACCCCGAAGGGAGCCCCCCATTTGAGGCC
GCTCATCAGACTGACAGGTTCTGGGACCTAAACAAGCACCTAGGGCCAGCCTCTCCTGTGGAGGTGCCCCCAGCTTCCTTGAGGAGCTCA
GTCCCCCCTTCCAAGAGGGGCACCGTGGGTGCTGGCTGTGGTTTCAACCAGCGCTGGCTCCCGGTCCACGTGCTCCGGGAGTGGCAGTGC
GGACACACCAGCGACCAGGACTCTTACACAGATTCCACCGATGGCTGGTCCAGCATCAACTGCGGCACACTGCCCCCTCCTATGAGCAAG
ATCCCCGCAGACCGCTACAGGGTGGAGGGCAGCTTCGCGCAGCCCCCGCTGAATGCCCCGAAGAGGGAGTGGTCCAGGAAGGCCTTTGGA
ATGCAAAGCATTTTTGGTCCCCATCGAAATGTTCGAAAGACTAAGGAAGATAAAAAGGGCGAAGAAACCAAAAGTCTGACTCTTGTCCTG
CATCGGGACTCCGGCTCCCTGGGATTCAATATTATTGGTGGCCGGCCGAGTGTGGATAACCACGATGGATCATCCAGTGAAGGAATCTTT
GTATCCAAGATAGTTGACAGTGGGCCTGCAGCCAAGGAAGGAGGCCTGCAAATTCATGACAGGATTATTGAGGTCAACGGCAGAGACTTA
TCCAGAGCAACTCATGACCAGGCTGTGGAAGCTTTCAAGACAGCCAAGGAGCCCATAGTGGTGCAGGTGTTGAGAAGAACACCAAGGACC
AAAATGTTCACGCCTCCATCAGAGTCTCAGCTGGTGGACACGGGAACCCAAACCGACATCACCTTTGAACATATCATGGCCCTCACTAAG
ATGTCCTCTCCCAGCCCACCCGTGCTGGATCCCTATCTCTTGCCAGAGGAGCATCCCTCAGCCCATGAATACTACGATCCAAATGACTAC
ATTGGAGACATCCATCAGGAGATGGACAGGGAGGAGCTGGAGCTGGAGGAAGTGGACCTCTACAGAATGAACAGCCAGGACAAGCTGGGC
CTCACTGTGTGCTACCGGACGGACGATGAAGACGACATTGGGATTTATATCAGTGAGATTGACCCTAACAGCATTGCAGCCAAGGATGGG
CGCATCCGAGAAGGAGACCGCATTATCCAGATTAATGGGATAGAGGTGCAGAACCGTGAAGAGGCTGTGGCTCTTCTAACCAGTGAAGAA
AATAAAAACTTTTCATTGCTGATTGCAAGGCCTGAACTCCAGCTGGATGAGGGCTGGATGGATGATGACAGGAACGACTTTCTGGATGAC
CTGCACATGGACATGCTGGAGGAGCAGCACCACCAGGCCATGCAATTCACAGCTAGCGTGCTGCAGCAGAAGAAGCACGACGAAGACGGT
GGGACCACAGATACAGCCACCATCTTGTCCAACCAGCACGAGAAGGACAGCGGTGTGGGGCGGACCGACGAGAGCACCCGTAATGACGAG
AGCTCGGAGCAAGAGAACAATGGCGACGACGCCACCGCATCCTCCAACCCGCTGGCGGGGCAGAGGAAGCTCACCTGCAGCCAGGACACC
TTGGGCAGCGGCGACCTGCCCTTCAGCAACGAGTCTTTCATTTCGGCCGACTGCACGGACGCCGACTACCTGGGGATCCCGGTGGACGAG
TGCGAGCGCTTCCGCGAGCTCCTGGAGCTCAAGTGCCAGGTGAAGAGCGCCACCCCTTACGGCCTGTACTACCCTAGCGGCCCCCTGGAC
GCCGGCAAGAGTGACCCTGAGAGCGTGGACAAGGAGCTGGAGCTGCTGAACGAAGAGCTGCGCAGCATCGAGCTGGAGTGCCTGAGCATC
GTGCGCGCCCACAAGATGCAGCAGCTCAAGGAGCAGTACCGCGAGTCCTGGATGCTGCACAACAGCGGCTTCCGCAACTACAACACCAGC
ATCGACGTGCGCAGACACGAGCTCTCAGATATCACCGAGCTCCCGGAGAAATCCGACAAGGACAGCTCGAGCGCCTACAACACAGGCGAG
AGCTGCCGCAGCACCCCGCTCACCCTGGAGATCTCCCCCGACAACTCCTTGAGGAGAGCGGCGGAGGGCATCAGCTGCCCGAGCAGCGAA
GGGGCTGTGGGGACCACGGAAGCCTACGGGCCAGCCTCCAAGAATCTGCTCTCCATCACGGAAGATCCCGAAGTGGGCACCCCTACCTAT
AGCCCGTCCCTGAAGGAGCTGGACCCCAACCAGCCCCTGGAAAGCAAAGAGCGGAGAGCCAGCGACGGGAGCCGGAGCCCCACGCCCAGC
CAGAAGCTGGGCAGCGCCTACCTGCCCTCCTATCACCACTCCCCATACAAGCACGCGCACATCCCGGCGCACGCCCAGCACTACCAGAGC
TACATGCAGCTGATCCAGCAGAAGTCGGCCGTGGAGTACGCGCAAAGCCAGATGAGCCTGGTGAGCATGTGCAAGGACCTGAGCTCTCCC
ACCCCGTCGGAGCCGCGCATGGAGTGGAAGGTGAAGATCCGCAGCGACGGGACGCGCTACATCACCAAGAGGCCCGTGCGGGACCGCCTG
CTGCGGGAGCGCGCCCTGAAGATCCGGGAAGAGCGCAGCGGCATGACCACCGACGACGACGCGGTGAGCGAGATGAAGATGGGGCGCTAC
TGGAGCAAGGAGGAGAGGAAGCAGCACCTGGTGAAGGCCAAGGAGCAGCGGCGGCGGCGCGAGTTCATGATGCAGAGCAGGTTGGATTGT
CTCAAGGAGCAGCAAGCAGCCGATGACAGGAAGGAGATGAACATTCTCGAACTGAGCCACAAAAAGATGATGAAGAAGAGGAATAAGAAA
ATCTTCGATAACTGGATGACGATCCAAGAACTCTTAACCCACGGCACAAAATCCCCGGACGGCACTAGAGTATACAATTCCTTCCTATCG
GTGACTACTGTATAATTTTCACTTCTGCATTATGTACATAAAGGAGACCACTACCACTGGGGTAGAAATTCCTGCCTCGTTCAATGCGGC
AAGTTTTTGTATATAAGATAAGTACGGTCTTCATGTTTATAGTCCAAATTTGCAAACCCTACAACTCTGGGTGTCATAGGTCTATTTTAA
GGGAAGAGAGAGAAAAACACCCTTACTATCTTGGAAGGCAATATTAACAAACAGAGCTTTTTTCAAATAGCAATTGTACTTTTCTACCTG
TACCCTTTTACATAAAGTGTTTAAATTTCAGAAAGATCTTTTATTAAGCATACTTTCACAGAATAACTTGTTTAAACTATATTCATATAA
AAAAGTTAAACACGCTTTTTTTCCTGCCTAAAACACAAATACAACTGCCAGTATGTATTTTTAATGGAACCCTATTTTATAATGGTACGT
TACTGAATGTGTTTCATATGCGTGACCGTTAAGATATTATCATTTAGGTGAAGGTTTCAACTCAAAACCACCCAACCCGGTGGTTAACGA
TTTAATACATATAACCAAACCGGCAGCGTTTAGAGTTGGGATATACATTTAAACATTTTCCTGGTTAAGGTTCCCAAGAGAGTGTAAAGG
TTTTAGCAGAAAGCAAAATATCTTGCATCTTTATGGAAGTTTAAAGCATGTTTGCAAATATTGCAGCCCATTGAAAGAATTTGCATGTAC
AGGAAAGTTGTGGATGGAGACGGTTTGTGGAATTTTAAGTGCTCATTGTAGTAAACTTTTGCTTTGTAGATTTGAAGGTACAGACTTATA
CAGGCAAGTTCACAAAATCATGATTAGTTACAAACAGTAAAATGAAGTTAAAATAAATTATTATTTTCTATTTGATATGTTTTGATGTGA

>73799_73799_4_RGS12-PDZRN3_RGS12_chr4_3319778_ENST00000543385_PDZRN3_chr3_73657835_ENST00000263666_length(amino acids)=1452AA_BP=627
MFRAGEASKRPLPGPSPPRVRSVEVARGRAGYGFTLSGQAPCVLSCVMRGSPADFVGLRAGDQILAVNEINVKKASHEDVVKLIGKCSGV
LHMVIAEGVGRFESCSSDEEGGLYEGKGWLKPKLDSKALGINRAERVVEEMQSGGIFNMIFENPSLCASNSEPLKLKQRSLSESAATRFD
VGHESINNPNPNMLSKEEISKVIHDDSVFSIGLESHDDFALDASILNVAMIVGYLGSIELPSTSSNLESDSLQAIRGCMRRLRAEQKIHS
LVTMKIMHDCVQLSTDKAGVVAEYPAEKLAFSAVCPDDRRFFGLVTMQTNDDGSLAQEEEGALRTSCHVFMVDPDLFNHKIHQGIARRFG
FECTADPDTNGCLEFPASSLPVLQFISVLYRDMGELIEGMRARAFLDGDADAHQNNSTSSNSDSGIGNFHQEEKSNRVLVVDLGGSSSRH
GPGGSAWDGVGGRGAQPWGAPWTGPFCPDPEGSPPFEAAHQTDRFWDLNKHLGPASPVEVPPASLRSSVPPSKRGTVGAGCGFNQRWLPV
HVLREWQCGHTSDQDSYTDSTDGWSSINCGTLPPPMSKIPADRYRVEGSFAQPPLNAPKREWSRKAFGMQSIFGPHRNVRKTKEDKKGEE
TKSLTLVLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNGRDLSRATHDQAVEAFKTAKEPIVVQ
VLRRTPRTKMFTPPSESQLVDTGTQTDITFEHIMALTKMSSPSPPVLDPYLLPEEHPSAHEYYDPNDYIGDIHQEMDREELELEEVDLYR
MNSQDKLGLTVCYRTDDEDDIGIYISEIDPNSIAAKDGRIREGDRIIQINGIEVQNREEAVALLTSEENKNFSLLIARPELQLDEGWMDD
DRNDFLDDLHMDMLEEQHHQAMQFTASVLQQKKHDEDGGTTDTATILSNQHEKDSGVGRTDESTRNDESSEQENNGDDATASSNPLAGQR
KLTCSQDTLGSGDLPFSNESFISADCTDADYLGIPVDECERFRELLELKCQVKSATPYGLYYPSGPLDAGKSDPESVDKELELLNEELRS
IELECLSIVRAHKMQQLKEQYRESWMLHNSGFRNYNTSIDVRRHELSDITELPEKSDKDSSSAYNTGESCRSTPLTLEISPDNSLRRAAE
GISCPSSEGAVGTTEAYGPASKNLLSITEDPEVGTPTYSPSLKELDPNQPLESKERRASDGSRSPTPSQKLGSAYLPSYHHSPYKHAHIP
AHAQHYQSYMQLIQQKSAVEYAQSQMSLVSMCKDLSSPTPSEPRMEWKVKIRSDGTRYITKRPVRDRLLRERALKIREERSGMTTDDDAV
SEMKMGRYWSKEERKQHLVKAKEQRRRREFMMQSRLDCLKEQQAADDRKEMNILELSHKKMMKKRNKKIFDNWMTIQELLTHGTKSPDGT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RGS12-PDZRN3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RGS12-PDZRN3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RGS12-PDZRN3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource