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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:RGS22-NIPAL2 (FusionGDB2 ID:73820)

Fusion Gene Summary for RGS22-NIPAL2

Fusion gene summary

Fusion gene information	Fusion gene name: RGS22-NIPAL2
	Fusion gene ID: 73820
		Hgene	Tgene
	Gene symbol	RGS22	NIPAL2
	Gene ID	26166	79815
	Gene name	regulator of G protein signaling 22	NIPA like domain containing 2
	Synonyms	CT145\|PRTD-NY2	NPAL2
	Cytomap	8q22.2	8q22.2
	Type of gene	protein-coding	protein-coding
	Description	regulator of G-protein signaling 22	NIPA-like protein 2
	Modification date	20200320	20200313
	UniProtAcc	.	Q9H841
	Ensembl transtripts involved in fusion gene	ENST00000360863, ENST00000523287, ENST00000523437, ENST00000519421,	ENST00000520545, ENST00000341166, ENST00000430223,
Fusion gene scores	* DoF score	4 X 4 X 3=48	8 X 7 X 8=448
	# samples	4	11
	** MAII score	log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/448*10)=-2.02599520853294 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: RGS22 [Title/Abstract] AND NIPAL2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	NIPAL2(99306231)-RGS22(100977658), # samples:3 RGS22(101059691)-NIPAL2(99266315), # samples:1
Anticipated loss of major functional domain due to fusion event.	RGS22-NIPAL2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across RGS22 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NIPAL2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUAD	TCGA-49-4490-01A	RGS22	chr8	101059691	-	NIPAL2	chr8	99266315	-

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Fusion Gene ORF analysis for RGS22-NIPAL2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000360863	ENST00000520545	RGS22	chr8	101059691	-	NIPAL2	chr8	99266315	-
5CDS-intron	ENST00000523287	ENST00000520545	RGS22	chr8	101059691	-	NIPAL2	chr8	99266315	-
5CDS-intron	ENST00000523437	ENST00000520545	RGS22	chr8	101059691	-	NIPAL2	chr8	99266315	-
Frame-shift	ENST00000523287	ENST00000341166	RGS22	chr8	101059691	-	NIPAL2	chr8	99266315	-
Frame-shift	ENST00000523287	ENST00000430223	RGS22	chr8	101059691	-	NIPAL2	chr8	99266315	-
In-frame	ENST00000360863	ENST00000341166	RGS22	chr8	101059691	-	NIPAL2	chr8	99266315	-
In-frame	ENST00000360863	ENST00000430223	RGS22	chr8	101059691	-	NIPAL2	chr8	99266315	-
In-frame	ENST00000523437	ENST00000341166	RGS22	chr8	101059691	-	NIPAL2	chr8	99266315	-
In-frame	ENST00000523437	ENST00000430223	RGS22	chr8	101059691	-	NIPAL2	chr8	99266315	-
intron-3CDS	ENST00000519421	ENST00000341166	RGS22	chr8	101059691	-	NIPAL2	chr8	99266315	-
intron-3CDS	ENST00000519421	ENST00000430223	RGS22	chr8	101059691	-	NIPAL2	chr8	99266315	-
intron-intron	ENST00000519421	ENST00000520545	RGS22	chr8	101059691	-	NIPAL2	chr8	99266315	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000360863	RGS22	chr8	101059691	-	ENST00000430223	NIPAL2	chr8	99266315	-	6180	2018	195	2051	618
ENST00000360863	RGS22	chr8	101059691	-	ENST00000341166	NIPAL2	chr8	99266315	-	6208	2018	195	2051	618
ENST00000523437	RGS22	chr8	101059691	-	ENST00000430223	NIPAL2	chr8	99266315	-	5990	1828	41	1861	606
ENST00000523437	RGS22	chr8	101059691	-	ENST00000341166	NIPAL2	chr8	99266315	-	6018	1828	41	1861	606

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000360863	ENST00000430223	RGS22	chr8	101059691	-	NIPAL2	chr8	99266315	-	0.00043589	0.9995641
ENST00000360863	ENST00000341166	RGS22	chr8	101059691	-	NIPAL2	chr8	99266315	-	0.000443892	0.9995561
ENST00000523437	ENST00000430223	RGS22	chr8	101059691	-	NIPAL2	chr8	99266315	-	0.000551161	0.99944884
ENST00000523437	ENST00000341166	RGS22	chr8	101059691	-	NIPAL2	chr8	99266315	-	0.000562565	0.9994374

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Fusion Genomic Features for RGS22-NIPAL2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RGS22-NIPAL2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:99306231/chr8:100977658)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	NIPAL2 Q9H841
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RGS22

chr8:101059691

chr8:99266315

ENST00000360863

267_277

607

1285.6666666666667

Compositional bias

Note=Poly-Glu

Tgene

NIPAL2

chr8:101059691

chr8:99266315

ENST00000341166

110_130

369.0

Transmembrane

Helical

Tgene

NIPAL2

chr8:101059691

chr8:99266315

ENST00000341166

144_164

369.0

Transmembrane

Helical

Tgene

NIPAL2

chr8:101059691

chr8:99266315

ENST00000341166

177_197

369.0

Transmembrane

Helical

Tgene

NIPAL2

chr8:101059691

chr8:99266315

ENST00000341166

209_229

369.0

Transmembrane

Helical

Tgene

NIPAL2

chr8:101059691

chr8:99266315

ENST00000341166

243_263

369.0

Transmembrane

Helical

Tgene

NIPAL2

chr8:101059691

chr8:99266315

ENST00000341166

278_298

369.0

Transmembrane

Helical

Tgene

NIPAL2

chr8:101059691

chr8:99266315

ENST00000341166

306_326

369.0

Transmembrane

Helical

Tgene

NIPAL2

chr8:101059691

chr8:99266315

ENST00000341166

46_66

369.0

Transmembrane

Helical

Tgene

NIPAL2

chr8:101059691

chr8:99266315

ENST00000341166

88_108

369.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RGS22

chr8:101059691

chr8:99266315

ENST00000360863

1142_1174

607

1285.6666666666667

Coiled coil

Ontology_term=ECO:0000255

Hgene

RGS22

chr8:101059691

chr8:99266315

ENST00000360863

767_771

607

1285.6666666666667

Compositional bias

Note=Poly-Leu

Hgene

RGS22

chr8:101059691

chr8:99266315

ENST00000360863

1021_1145

607

1285.6666666666667

Domain

RGS 2

Hgene

RGS22

chr8:101059691

chr8:99266315

ENST00000360863

852_980

607

1285.6666666666667

Domain

RGS 1

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Fusion Gene Sequence for RGS22-NIPAL2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>73820_73820_1_RGS22-NIPAL2_RGS22_chr8_101059691_ENST00000360863_NIPAL2_chr8_99266315_ENST00000341166_length(transcript)=6208nt_BP=2018nt
CCGGCCTCGGCCTCCCTGGGCGGCCGTATTGTCTAAGCTCCATAGCAACCCCGGCGCGGCGCCGGCCACGCTAGCCAGCGTAGCTCCGGA
GCCCGCGCGCCGTCGCCGCGTCGCTCAGGCCCTGACCCGCGCTGGACCCGCGCGCTAGGGCCCTGACGGCCCGCGCGGGCTCCAGGCGCG
GGCAGCGGGGACGGCATGCCCGAGAAGAGGCTCACCGCGGAGCCACCAACTATTACAGAAGAAGAATTTGAAGATTCTCTGGCAACAGAT
GATTTCCTTGTAGACTACTTTAATGAATTCCTAAGCCTTCCAACCTTTTCAGAGGCAATTAGATTTAATGCAGATTATGGAGTTTTTGAA
GTAGCTAATGATGCTCCACAATTTCTGGAAAAACAACTGAAAAAAATTCTACAAAACCAGCAACCTCGAAATCCCATTTATGATGTTGTA
AGGAAAGGAAAGAATGAGGTTAAACCTGTTCAAATGAATGCCCCCGATGAAGATGAGACCATTAATGTCAACTACAATATTATGTGTCTC
AGTCGTGAAGAAGGTATTAAGTGGATCAAAAAAGAAAGACTTCCAGCATTTCTGGAAAGTGATTGTTACTTTGAATACAGGTTAGCCAAA
TTGGTCTCACAAGTAAGATGGAGCAAGTCCGGCATGAATTTCACAGTAGGATCAAATTTTTCTCCCTGGATCGTGAAAAAACCACCCAGT
CTACCACCTCCTGCCACTGAAGAAGATAATCTTGTAATTATGAAAAAGTTCTATGTATCACTTGGTGAGGCTTCCTATACTCAAACAAAA
GATTGGTTTGCATTAGCAAAACAAAGTCAGCAAACAGTATCAACCTTTTCGTTACCCTGTTGTGTACCCTACAACAAACTTAAATCACCA
GCTATTTCATCTGTTTCTGAGAATTTTATCTTTGATGATGGAGTTCACCCTAGGACAAAAAAGGACCCATCTAAAACCAACAAATTGATT
TCTGAATTTGAAGAAGAAGAAGGAGAAGAAGAAGAGGTGTCTGTATCTCTACAAGACACTCCTTCTCAAGCTCTTCTGAGAGTATACCTT
GAAAAGAAACAGGATGTTGATGAAAGCCTGACAATGCATTTCTCAACATGTGAAGAATTTTTAAGCTCCTATATATACTTTATTTTGAGA
GGAGCAATTCAGCAAATTGTTGGAAAGCCAGTTGGAGAAACCCCAGACTATATAAACTTCAACAATATAACAAAAGTGTCATTTGATGAT
TGTTTTGAGTCTATTCATGGCAAGAATTTTTTAAGTGAATTAGTTCAAACTACAAAGGAGAGGTCAGAAGAGATAGAACAAACAAGTTTA
AGTTCAAAGAATGAGAGCGCTGGACCAGAGAGCAGGGCGGACTGGTGTATTTCTCATAGGACTTATGACATTGGCAATAGAAAGGAGTTT
GAAAGATTTAAGAAATTTATAAAAGGTACATTGGGAGAGAGATATTGGTGGCTATGGATGGATATTGAGAGGTTAAAAGTTCTTAAGGAT
CCTGGAAGACATCAAAGACATCTTGAGAAGATGAAAAAATGCTATCTAGTGAGCAATGGAGATTACTACCTTTCTGCAGAAATCTTATCA
AAATTTAAACTGTTAGATGGATCACAGTGGAATGAAGAGCATTTAAGAAATATTCAGTCTGAAGTTTTAAAACCTTTACTTCTGTATTGG
GCACCAAGATTCTGTGTTACTCATTCAGCCTCAACAAAATATGCTAGTGCTGAACTGAAATTCTGGCACCTCCGTCAAGCAAAACCAAGG
AAGGATATTGACCCTTTTCCACAAATGGCAACCCTCTTGCCATTAAGACCCAAATCTTGCATTCCACAGATACCTGAGATCCAGAAAGAA
GAATTCAGCTTATCACAACCTCCTAAATCTCCCAATAAATCACCTGAAGTAAAAACAGCAACTCAAAAGCCTTGGAAGCGGGAGCTTTTG
TATCCAGGTTCTTCTAAGGATGATGTGATTGAGAAAGGATTCACCTTTTTGGAGTTTTGCTGGCTATTTTAGGAAACTTGGTGATCAGTA
TTTCTCTAAATATTCAGAAATATTCTCACCTTCAGCTGGCACAACAAGAGCACCCAAGGCCATACTTCAAGAGTGTGCTGTGGTGGGGTG
GTGTCCTGCTGATGGCCGTGGGAGAGACGGGGAACTTTGCAGCCTATGGATTTGCTCCCATTACTCTGATCGCTCCGTTAGGCTGTGTGT
CTGTTACAGGTAGTGCCATTATTTCTGTTACATTTCTGAAAGACAATTTGAGAGCCTCAGACTTACTCGGTACGACACTGGCATTTGCAG
GAACATATTTACTGGTGAACTTTGCTCCAAATATAACTCAGGCAATCTCAGCAAGAACAGTACAGTATTACCTTGTCGGATGGCAGTTCC
TGATCTATGTGATTTTAGAAATATTAATTTTCTGCATTCTCCTGTATTTCTATAAAAGAAAAGGAATGAAGCATATGGTGATTCTGCTAA
CCCTGGTGGCAATTCTAGCCTCATTGACTGTTATTTCAGTAAAGGCCGTCTCAGGCATGATCACTTTTTCTGTGATGGATAAAATGCAAC
TAACTTACCCCATTTTCTATATCATGTTTATCATCATGATAGCATCTTGTGTTTTCCAAGTCAAGTTCCTGAATCAAGCCACGAAACTCT
ACAATACGACAACAGTGGTGCCAGTTAATCATATTTTCTTTACAATCAGTGCCATCATTGCAGGTATCATATTTTATCAGGAATTCCTTG
GTGCTCCTTTTCTCACTGTATTTATATATCTTTTTGGGTGTTTTCTGTCATTCCTTGGTGTATTTTTGGTCACAAGAAATCGAGAAAAGG
AACATCTGCAACAGTCTTATATTGATTTTGGAAATATTCCTGACACAACCCCAGAGAGAAAGGCTTGGAGGGAAACAAATGTTGGACAAA
ATACAACCAGATTCACATAGCTTATCCTATGGAACTTTGCCTGATGGAAGTGACTCAACAAAGAGCCAAAGTGGAGAGAAGAAAGAGGTC
TAAATGCTGAGAAGGATGGCTGTTGGCCTGTTATTCGATACCACCTTTTTAAAAAATTGCACATGTTCAATTTGTGTCAGCAGCTCTTTT
ATAAGCTAACATGTGCTAGCATTCATTTCAGTCCTTTCCCCCACCTCAGCGTCTATGGACAATCGGGGACTTCCTAAGCTCTGACAGTCT
AATATTTCCATGGAATGTGATTTGGAGTGTTCCCCACACCCTGGACCTCTCCCTAGTGATTATCTAGCCAGCTACACCTTACTCAGAGCC
CGGCTGCTCTAGCAGGAATGTTGCACAGAAACATACATTTGCGGTTTGGCCACAGGTCGCATAGGTGGCTTCTCCCACGGGTAGTGTCAG
TTGCTTCACTTTAAAAAGTCACTTCAGCCCCACAACCTCACTCCCAAAAGAAAGGTTTGAGAGCGCTCATTTTTTTTCTAAGACACCTTT
TATAAGCCTCCCTATAAAAATCTCACCTTTCAAGTACTAAGTTAGAATTGCAAGTCATCTTTTCTGAAAACTAATGCTATCAAAGTCCTC
CTTTGAAAATTAAGGGTCTCTTTAAAATTAGAATTTATAAATGGCATTCAGTGATAGTGTACACCAAAATTAAAAGACCTTGACTGGTGG
GCTTTTTACGTGTAAGGAAGAGGAAGTTTAAGAAGTAGGACTCTGCTTGTTTCAGTAGCCCATGTACTAAAATAGGAACAATGCAGAGAT
TAGCACAGCCCCTGCACAAGGCTGACACATAAATTCATGAAGCGTTAGAGACAAAAAGTAGGACTAATGTTTGTTTATTTTTTAATAAAA
ATCTAGAATGGTGATGTTTTCTTCAGCTGTATGATTCTATCATACTTGAAACTGAAGAAAAATTTAATATCCTATGTCTTTTTTATAGAT
CTTATAATTTATCAAGTGGATTTATATGTCTTATTCTCCATATAAGTCTAAAAAATCACATTTAAATTCTTAGTGATAGTTTCACTACAC
ATCATTTCTTCCCAAAGTCATTACCTCAAGCTTTGTAAATTCTTCTAGATAAAAGGAGAGTTGTGATTAGAGAACTGAATTTCAGCCATT
TAAACCTGTAGACATAGAAAACAACCCAGTGGTCAAACCTGAGCTTCAAGAGGAAGCCCAAGTCCTCCTGTTTCCTGAATGGCTTTTCCA
CTCCAATTCATCACATATCTGCTAAGACACATTTGCAGGTAGAATCCATAATAATATCTGTTATTTATGATCTACCTAATATTTAAAGGA
GAAGAAAAGAAGTAGCCTTCGTTGCAGCCAACATCCAACAATAAGTCCCACCCTTAATGACATTTCAAAGCCTTCAGATCACTTCTGACA
TGTCTGTCCAATATCATTCCAATCAATAGTCTTGCATTTAAATAGGTTGTTTAACTCGGTGGTATTGAGACTGTAACCTTAATGGCTCAG
GTCTTTTAGCTTTGTTCTTTGTCATAATCTGCACTCCTGGCCAGACTGACCAAACCTGGCTGCAAAGGAAAGAGATTTGAATTGATCACC
AATGTATGAAAAATACAGAACCCATGTCTGGCTCCTAAACTCCTGGTAATAATTCCCGCCATCGTAGCAAGTGTCCCATGCATTCAGATA
AAGCAGTCATAATTTATGGTGTATTTTACCGAATTGGTCCAGCATATTGGTCCTACAAGGCTCAGCCAAGAAATGTATCTGGTGCCTTAA
ACTACAGATTTCTGGTGACTCTTAAAACTGGTTTACAAAGATTGAGAAAACAATTAGATTGAAGAGTTTTGCTTCAAGTAGACCTGCATT
CATAGCTAGAGTGCATGAGATTTTCAGCACTGTAGAATTTCACACAGGCACAAGCATAACACCAGTACTTTAGCAGCCGCCAACAGTTGC
ATCTATTAAACGTTTTGAGAAATGACATTGACTTATGCACATTTAAGCAATCAACAATGTTTTAGAAGTCCAGGTAACATATAAAATATA
TTCAGACCTAGTTTTACTTTCCATATTGTTGCTCCAAAGTAAGGTAAATAGGAGTTTTAGTTGTACTGGCCTGTAAGATTTTTTAAATTA
CACAGTGCATGACAACAACTAAAGCCAACTCAGTCCTTCTCTTGGCATTGTGAGTTGAGGACCTTTAGCCAACTGTTAGCTCATCTGACT
ATCTGTCTAGACCAAGGGTCGGCAAAGTTTTCAGTAAAGACCCACAGAGTACATATTTTGGAGTTTGTGTTGTCTGTACCAACAGACAGA
CATGGTGTCTGTCCCAACTACCCAACTCTGCCATTGTAGCACTAAAGCAGCCATAGACAAGATGTAAACAGAAGAGCATGGCTGTGTTCC
AGTAAAACTTTATTTACAGGCCAGGCATGGTGGCTCATGCCTGTAATCCCAGCACTCTGGGAGGCTGAGGCTGACAGATCATCTGAGGTT
AGGAGTTTGGGACCAGCCTGGTCAACATAGTGAAACCCCATCTCTACTAAAAGTACAAAAATTAGCCAGGCATGACGGTGGGTGCCTGGA
GTCCCAGCTACCTGGGAGGCTGAGGCAGGAGAATCACTTGAACCCGGGAGGTGGAGGTTGCAGTGAGCCGAGATCATGCCATTGCACTCC
AGCCTGGGCGACAGAGTAAGACTGTCTCAAAAACAAACAAACAAACAAACAAACAAAAACAAGTGGCCAGTCTGTGAGCTATAGTTCCCA
ACACCTGGTCTAGACTCTTCTGCCCTTGCTCTGCAGCTTCTTTCCTGTTGATTGGGCATTCAGGGAAGGAGTTTAAAAAGTGACACTCAT
GGCTCATGACAAATGAGATACTTTGGGAGTGTGGAAACATGGCTTGATATTTGCCTTCAGATATTTTTGCTTATATAAGTTCTAAATGGA
AGTGATAAGTTCATTCTTAGGGTCCAAGTTGAAAGGCAGTGGTTCTTTTGTGAACACCACTAACTACATTCGAAAAGCCTCTCCAATTCC
ACATTCCAAGTCTATAACAGCTTTGGAAATGAGTAACAATGACCTCTCATGTAGTAGATTAAAGCAGAGGCCTTTGCCATATGATTGTTT

>73820_73820_1_RGS22-NIPAL2_RGS22_chr8_101059691_ENST00000360863_NIPAL2_chr8_99266315_ENST00000341166_length(amino acids)=618AA_BP=
MPEKRLTAEPPTITEEEFEDSLATDDFLVDYFNEFLSLPTFSEAIRFNADYGVFEVANDAPQFLEKQLKKILQNQQPRNPIYDVVRKGKN
EVKPVQMNAPDEDETINVNYNIMCLSREEGIKWIKKERLPAFLESDCYFEYRLAKLVSQVRWSKSGMNFTVGSNFSPWIVKKPPSLPPPA
TEEDNLVIMKKFYVSLGEASYTQTKDWFALAKQSQQTVSTFSLPCCVPYNKLKSPAISSVSENFIFDDGVHPRTKKDPSKTNKLISEFEE
EEGEEEEVSVSLQDTPSQALLRVYLEKKQDVDESLTMHFSTCEEFLSSYIYFILRGAIQQIVGKPVGETPDYINFNNITKVSFDDCFESI
HGKNFLSELVQTTKERSEEIEQTSLSSKNESAGPESRADWCISHRTYDIGNRKEFERFKKFIKGTLGERYWWLWMDIERLKVLKDPGRHQ
RHLEKMKKCYLVSNGDYYLSAEILSKFKLLDGSQWNEEHLRNIQSEVLKPLLLYWAPRFCVTHSASTKYASAELKFWHLRQAKPRKDIDP

--------------------------------------------------------------
>73820_73820_2_RGS22-NIPAL2_RGS22_chr8_101059691_ENST00000360863_NIPAL2_chr8_99266315_ENST00000430223_length(transcript)=6180nt_BP=2018nt
CCGGCCTCGGCCTCCCTGGGCGGCCGTATTGTCTAAGCTCCATAGCAACCCCGGCGCGGCGCCGGCCACGCTAGCCAGCGTAGCTCCGGA
GCCCGCGCGCCGTCGCCGCGTCGCTCAGGCCCTGACCCGCGCTGGACCCGCGCGCTAGGGCCCTGACGGCCCGCGCGGGCTCCAGGCGCG
GGCAGCGGGGACGGCATGCCCGAGAAGAGGCTCACCGCGGAGCCACCAACTATTACAGAAGAAGAATTTGAAGATTCTCTGGCAACAGAT
GATTTCCTTGTAGACTACTTTAATGAATTCCTAAGCCTTCCAACCTTTTCAGAGGCAATTAGATTTAATGCAGATTATGGAGTTTTTGAA
GTAGCTAATGATGCTCCACAATTTCTGGAAAAACAACTGAAAAAAATTCTACAAAACCAGCAACCTCGAAATCCCATTTATGATGTTGTA
AGGAAAGGAAAGAATGAGGTTAAACCTGTTCAAATGAATGCCCCCGATGAAGATGAGACCATTAATGTCAACTACAATATTATGTGTCTC
AGTCGTGAAGAAGGTATTAAGTGGATCAAAAAAGAAAGACTTCCAGCATTTCTGGAAAGTGATTGTTACTTTGAATACAGGTTAGCCAAA
TTGGTCTCACAAGTAAGATGGAGCAAGTCCGGCATGAATTTCACAGTAGGATCAAATTTTTCTCCCTGGATCGTGAAAAAACCACCCAGT
CTACCACCTCCTGCCACTGAAGAAGATAATCTTGTAATTATGAAAAAGTTCTATGTATCACTTGGTGAGGCTTCCTATACTCAAACAAAA
GATTGGTTTGCATTAGCAAAACAAAGTCAGCAAACAGTATCAACCTTTTCGTTACCCTGTTGTGTACCCTACAACAAACTTAAATCACCA
GCTATTTCATCTGTTTCTGAGAATTTTATCTTTGATGATGGAGTTCACCCTAGGACAAAAAAGGACCCATCTAAAACCAACAAATTGATT
TCTGAATTTGAAGAAGAAGAAGGAGAAGAAGAAGAGGTGTCTGTATCTCTACAAGACACTCCTTCTCAAGCTCTTCTGAGAGTATACCTT
GAAAAGAAACAGGATGTTGATGAAAGCCTGACAATGCATTTCTCAACATGTGAAGAATTTTTAAGCTCCTATATATACTTTATTTTGAGA
GGAGCAATTCAGCAAATTGTTGGAAAGCCAGTTGGAGAAACCCCAGACTATATAAACTTCAACAATATAACAAAAGTGTCATTTGATGAT
TGTTTTGAGTCTATTCATGGCAAGAATTTTTTAAGTGAATTAGTTCAAACTACAAAGGAGAGGTCAGAAGAGATAGAACAAACAAGTTTA
AGTTCAAAGAATGAGAGCGCTGGACCAGAGAGCAGGGCGGACTGGTGTATTTCTCATAGGACTTATGACATTGGCAATAGAAAGGAGTTT
GAAAGATTTAAGAAATTTATAAAAGGTACATTGGGAGAGAGATATTGGTGGCTATGGATGGATATTGAGAGGTTAAAAGTTCTTAAGGAT
CCTGGAAGACATCAAAGACATCTTGAGAAGATGAAAAAATGCTATCTAGTGAGCAATGGAGATTACTACCTTTCTGCAGAAATCTTATCA
AAATTTAAACTGTTAGATGGATCACAGTGGAATGAAGAGCATTTAAGAAATATTCAGTCTGAAGTTTTAAAACCTTTACTTCTGTATTGG
GCACCAAGATTCTGTGTTACTCATTCAGCCTCAACAAAATATGCTAGTGCTGAACTGAAATTCTGGCACCTCCGTCAAGCAAAACCAAGG
AAGGATATTGACCCTTTTCCACAAATGGCAACCCTCTTGCCATTAAGACCCAAATCTTGCATTCCACAGATACCTGAGATCCAGAAAGAA
GAATTCAGCTTATCACAACCTCCTAAATCTCCCAATAAATCACCTGAAGTAAAAACAGCAACTCAAAAGCCTTGGAAGCGGGAGCTTTTG
TATCCAGGTTCTTCTAAGGATGATGTGATTGAGAAAGGATTCACCTTTTTGGAGTTTTGCTGGCTATTTTAGGAAACTTGGTGATCAGTA
TTTCTCTAAATATTCAGAAATATTCTCACCTTCAGCTGGCACAACAAGAGCACCCAAGGCCATACTTCAAGAGTGTGCTGTGGTGGGGTG
GTGTCCTGCTGATGGCCGTGGGAGAGACGGGGAACTTTGCAGCCTATGGATTTGCTCCCATTACTCTGATCGCTCCGTTAGGCTGTGTGT
CTGTTACAGGTAGTGCCATTATTTCTGTTACATTTCTGAAAGACAATTTGAGAGCCTCAGACTTACTCGGTACGACACTGGCATTTGCAG
GAACATATTTACTGGTGAACTTTGCTCCAAATATAACTCAGGCAATCTCAGCAAGAACAGTACAGTATTACCTTGTCGGATGGCAGTTCC
TGATCTATGTGATTTTAGAAATATTAATTTTCTGCATTCTCCTGTATTTCTATAAAAGAAAAGGAATGAAGCATATGGTGATTCTGCTAA
CCCTGGTGGCAATTCTAGCCTCATTGACTGTTATTTCAGTAAAGGCCGTCTCAGGCATGATCACTTTTTCTGTGATGGATAAAATGCAAC
TAACTTACCCCATTTTCTATATCATGTTTATCATCATGATAGCATCTTGTGTTTTCCAAGTCAAGTTCCTGAATCAAGCCACGAAACTCT
ACAATACGACAACAGTGGTGCCAGTTAATCATATTTTCTTTACAATCAGTGCCATCATTGCAGGTATCATATTTTATCAGGAATTCCTTG
GTGCTCCTTTTCTCACTGTATTTATATATCTTTTTGGGTGTTTTCTGTCATTCCTTGGTGTATTTTTGGTCACAAGAAATCGAGAAAAGG
AACATCTGCAACAGTCTTATATTGATTTTGGAAATATTCCTGGGAAACAAATGTTGGACAAAATACAACCAGATTCACATAGCTTATCCT
ATGGAACTTTGCCTGATGGAAGTGACTCAACAAAGAGCCAAAGTGGAGAGAAGAAAGAGGTCTAAATGCTGAGAAGGATGGCTGTTGGCC
TGTTATTCGATACCACCTTTTTAAAAAATTGCACATGTTCAATTTGTGTCAGCAGCTCTTTTATAAGCTAACATGTGCTAGCATTCATTT
CAGTCCTTTCCCCCACCTCAGCGTCTATGGACAATCGGGGACTTCCTAAGCTCTGACAGTCTAATATTTCCATGGAATGTGATTTGGAGT
GTTCCCCACACCCTGGACCTCTCCCTAGTGATTATCTAGCCAGCTACACCTTACTCAGAGCCCGGCTGCTCTAGCAGGAATGTTGCACAG
AAACATACATTTGCGGTTTGGCCACAGGTCGCATAGGTGGCTTCTCCCACGGGTAGTGTCAGTTGCTTCACTTTAAAAAGTCACTTCAGC
CCCACAACCTCACTCCCAAAAGAAAGGTTTGAGAGCGCTCATTTTTTTTCTAAGACACCTTTTATAAGCCTCCCTATAAAAATCTCACCT
TTCAAGTACTAAGTTAGAATTGCAAGTCATCTTTTCTGAAAACTAATGCTATCAAAGTCCTCCTTTGAAAATTAAGGGTCTCTTTAAAAT
TAGAATTTATAAATGGCATTCAGTGATAGTGTACACCAAAATTAAAAGACCTTGACTGGTGGGCTTTTTACGTGTAAGGAAGAGGAAGTT
TAAGAAGTAGGACTCTGCTTGTTTCAGTAGCCCATGTACTAAAATAGGAACAATGCAGAGATTAGCACAGCCCCTGCACAAGGCTGACAC
ATAAATTCATGAAGCGTTAGAGACAAAAAGTAGGACTAATGTTTGTTTATTTTTTAATAAAAATCTAGAATGGTGATGTTTTCTTCAGCT
GTATGATTCTATCATACTTGAAACTGAAGAAAAATTTAATATCCTATGTCTTTTTTATAGATCTTATAATTTATCAAGTGGATTTATATG
TCTTATTCTCCATATAAGTCTAAAAAATCACATTTAAATTCTTAGTGATAGTTTCACTACACATCATTTCTTCCCAAAGTCATTACCTCA
AGCTTTGTAAATTCTTCTAGATAAAAGGAGAGTTGTGATTAGAGAACTGAATTTCAGCCATTTAAACCTGTAGACATAGAAAACAACCCA
GTGGTCAAACCTGAGCTTCAAGAGGAAGCCCAAGTCCTCCTGTTTCCTGAATGGCTTTTCCACTCCAATTCATCACATATCTGCTAAGAC
ACATTTGCAGGTAGAATCCATAATAATATCTGTTATTTATGATCTACCTAATATTTAAAGGAGAAGAAAAGAAGTAGCCTTCGTTGCAGC
CAACATCCAACAATAAGTCCCACCCTTAATGACATTTCAAAGCCTTCAGATCACTTCTGACATGTCTGTCCAATATCATTCCAATCAATA
GTCTTGCATTTAAATAGGTTGTTTAACTCGGTGGTATTGAGACTGTAACCTTAATGGCTCAGGTCTTTTAGCTTTGTTCTTTGTCATAAT
CTGCACTCCTGGCCAGACTGACCAAACCTGGCTGCAAAGGAAAGAGATTTGAATTGATCACCAATGTATGAAAAATACAGAACCCATGTC
TGGCTCCTAAACTCCTGGTAATAATTCCCGCCATCGTAGCAAGTGTCCCATGCATTCAGATAAAGCAGTCATAATTTATGGTGTATTTTA
CCGAATTGGTCCAGCATATTGGTCCTACAAGGCTCAGCCAAGAAATGTATCTGGTGCCTTAAACTACAGATTTCTGGTGACTCTTAAAAC
TGGTTTACAAAGATTGAGAAAACAATTAGATTGAAGAGTTTTGCTTCAAGTAGACCTGCATTCATAGCTAGAGTGCATGAGATTTTCAGC
ACTGTAGAATTTCACACAGGCACAAGCATAACACCAGTACTTTAGCAGCCGCCAACAGTTGCATCTATTAAACGTTTTGAGAAATGACAT
TGACTTATGCACATTTAAGCAATCAACAATGTTTTAGAAGTCCAGGTAACATATAAAATATATTCAGACCTAGTTTTACTTTCCATATTG
TTGCTCCAAAGTAAGGTAAATAGGAGTTTTAGTTGTACTGGCCTGTAAGATTTTTTAAATTACACAGTGCATGACAACAACTAAAGCCAA
CTCAGTCCTTCTCTTGGCATTGTGAGTTGAGGACCTTTAGCCAACTGTTAGCTCATCTGACTATCTGTCTAGACCAAGGGTCGGCAAAGT
TTTCAGTAAAGACCCACAGAGTACATATTTTGGAGTTTGTGTTGTCTGTACCAACAGACAGACATGGTGTCTGTCCCAACTACCCAACTC
TGCCATTGTAGCACTAAAGCAGCCATAGACAAGATGTAAACAGAAGAGCATGGCTGTGTTCCAGTAAAACTTTATTTACAGGCCAGGCAT
GGTGGCTCATGCCTGTAATCCCAGCACTCTGGGAGGCTGAGGCTGACAGATCATCTGAGGTTAGGAGTTTGGGACCAGCCTGGTCAACAT
AGTGAAACCCCATCTCTACTAAAAGTACAAAAATTAGCCAGGCATGACGGTGGGTGCCTGGAGTCCCAGCTACCTGGGAGGCTGAGGCAG
GAGAATCACTTGAACCCGGGAGGTGGAGGTTGCAGTGAGCCGAGATCATGCCATTGCACTCCAGCCTGGGCGACAGAGTAAGACTGTCTC
AAAAACAAACAAACAAACAAACAAACAAAAACAAGTGGCCAGTCTGTGAGCTATAGTTCCCAACACCTGGTCTAGACTCTTCTGCCCTTG
CTCTGCAGCTTCTTTCCTGTTGATTGGGCATTCAGGGAAGGAGTTTAAAAAGTGACACTCATGGCTCATGACAAATGAGATACTTTGGGA
GTGTGGAAACATGGCTTGATATTTGCCTTCAGATATTTTTGCTTATATAAGTTCTAAATGGAAGTGATAAGTTCATTCTTAGGGTCCAAG
TTGAAAGGCAGTGGTTCTTTTGTGAACACCACTAACTACATTCGAAAAGCCTCTCCAATTCCACATTCCAAGTCTATAACAGCTTTGGAA
ATGAGTAACAATGACCTCTCATGTAGTAGATTAAAGCAGAGGCCTTTGCCATATGATTGTTTTTTGGCTTAAATGTTTGCTTGCCCTGTA

>73820_73820_2_RGS22-NIPAL2_RGS22_chr8_101059691_ENST00000360863_NIPAL2_chr8_99266315_ENST00000430223_length(amino acids)=618AA_BP=
MPEKRLTAEPPTITEEEFEDSLATDDFLVDYFNEFLSLPTFSEAIRFNADYGVFEVANDAPQFLEKQLKKILQNQQPRNPIYDVVRKGKN
EVKPVQMNAPDEDETINVNYNIMCLSREEGIKWIKKERLPAFLESDCYFEYRLAKLVSQVRWSKSGMNFTVGSNFSPWIVKKPPSLPPPA
TEEDNLVIMKKFYVSLGEASYTQTKDWFALAKQSQQTVSTFSLPCCVPYNKLKSPAISSVSENFIFDDGVHPRTKKDPSKTNKLISEFEE
EEGEEEEVSVSLQDTPSQALLRVYLEKKQDVDESLTMHFSTCEEFLSSYIYFILRGAIQQIVGKPVGETPDYINFNNITKVSFDDCFESI
HGKNFLSELVQTTKERSEEIEQTSLSSKNESAGPESRADWCISHRTYDIGNRKEFERFKKFIKGTLGERYWWLWMDIERLKVLKDPGRHQ
RHLEKMKKCYLVSNGDYYLSAEILSKFKLLDGSQWNEEHLRNIQSEVLKPLLLYWAPRFCVTHSASTKYASAELKFWHLRQAKPRKDIDP

--------------------------------------------------------------
>73820_73820_3_RGS22-NIPAL2_RGS22_chr8_101059691_ENST00000523437_NIPAL2_chr8_99266315_ENST00000341166_length(transcript)=6018nt_BP=1828nt
GACGGCCCGCGCGGGCTCCAGGCGCGGGCAGCGGGGACGGCATGCCCGAGAAGAGGCTCACCGCGGAGCCACCAACTATTACAGAAGAAG
AATTTGAAGATTCTCTGGCAACAGATGATTTCCTTGTAGACTACTTTAATGAATTCCTAAGCCTTCCAACCTTTTCAGAGGCAATTAGAT
TTAATGCAGATTATGGAGTTTTTGAAGTAGCTAATGATGCTCCACAATTTCTGGAAAAACAACTGAAAAAAATTCTACAAAACCAGCAAC
CTCGAAATCCCATTTATGATGTTGTAAGGAAAGGAAAGAATGAGGTTAAACCTGTTCAAATGAATGCCCCCGATGAAGATGAGACCATTA
ATGTCAACTACAATATTATGTGTCTCAGTCGTGAAGAAGGTATTAAGTGGATCAAAAAAGAAAGACTTCCAGCATTTCTGGAAAGTGATT
GTTACTTTGAATACAGGTTAGCCAAATTGGTCTCACAAGTAAGATGGAGCAAGTCCGGCATGAATTTCACAGTAGGATCAAATTTTTCTC
CCTGGATCGTGAAAAAACCACCCAGTCTACCACCTCCTGCCACTGAAGAAGATAATCTTGCTTCCTATACTCAAACAAAAGATTGGTTTG
CATTAGCAAAACAAAGTCAGCAAACAGTATCAACCTTTTCGTTACCCTGTTGTGTACCCTACAACAAACTTAAATCACCAGCTATTTCAT
CTGTTTCTGAGAATTTTATCTTTGATGATGGAGTTCACCCTAGGACAAAAAAGGACCCATCTAAAACCAACAAATTGATTTCTGAATTTG
AAGAAGAAGAAGGAGAAGAAGAAGAGGTGTCTGTATCTCTACAAGACACTCCTTCTCAAGCTCTTCTGAGAGTATACCTTGAAAAGAAAC
AGGATGTTGATGAAAGCCTGACAATGCATTTCTCAACATGTGAAGAATTTTTAAGCTCCTATATATACTTTATTTTGAGAGGAGCAATTC
AGCAAATTGTTGGAAAGCCAGTTGGAGAAACCCCAGACTATATAAACTTCAACAATATAACAAAAGTGTCATTTGATGATTGTTTTGAGT
CTATTCATGGCAAGAATTTTTTAAGTGAATTAGTTCAAACTACAAAGGAGAGGTCAGAAGAGATAGAACAAACAAGTTTAAGTTCAAAGA
ATGAGAGCGCTGGACCAGAGAGCAGGGCGGACTGGTGTATTTCTCATAGGACTTATGACATTGGCAATAGAAAGGAGTTTGAAAGATTTA
AGAAATTTATAAAAGGTACATTGGGAGAGAGATATTGGTGGCTATGGATGGATATTGAGAGGTTAAAAGTTCTTAAGGATCCTGGAAGAC
ATCAAAGACATCTTGAGAAGATGAAAAAATGCTATCTAGTGAGCAATGGAGATTACTACCTTTCTGCAGAAATCTTATCAAAATTTAAAC
TGTTAGATGGATCACAGTGGAATGAAGAGCATTTAAGAAATATTCAGTCTGAAGTTTTAAAACCTTTACTTCTGTATTGGGCACCAAGAT
TCTGTGTTACTCATTCAGCCTCAACAAAATATGCTAGTGCTGAACTGAAATTCTGGCACCTCCGTCAAGCAAAACCAAGGAAGGATATTG
ACCCTTTTCCACAAATGGCAACCCTCTTGCCATTAAGACCCAAATCTTGCATTCCACAGATACCTGAGATCCAGAAAGAAGAATTCAGCT
TATCACAACCTCCTAAATCTCCCAATAAATCACCTGAAGTAAAAACAGCAACTCAAAAGCCTTGGAAGCGGGAGCTTTTGTATCCAGGTT
CTTCTAAGGATGATGTGATTGAGAAAGGATTCACCTTTTTGGAGTTTTGCTGGCTATTTTAGGAAACTTGGTGATCAGTATTTCTCTAAA
TATTCAGAAATATTCTCACCTTCAGCTGGCACAACAAGAGCACCCAAGGCCATACTTCAAGAGTGTGCTGTGGTGGGGTGGTGTCCTGCT
GATGGCCGTGGGAGAGACGGGGAACTTTGCAGCCTATGGATTTGCTCCCATTACTCTGATCGCTCCGTTAGGCTGTGTGTCTGTTACAGG
TAGTGCCATTATTTCTGTTACATTTCTGAAAGACAATTTGAGAGCCTCAGACTTACTCGGTACGACACTGGCATTTGCAGGAACATATTT
ACTGGTGAACTTTGCTCCAAATATAACTCAGGCAATCTCAGCAAGAACAGTACAGTATTACCTTGTCGGATGGCAGTTCCTGATCTATGT
GATTTTAGAAATATTAATTTTCTGCATTCTCCTGTATTTCTATAAAAGAAAAGGAATGAAGCATATGGTGATTCTGCTAACCCTGGTGGC
AATTCTAGCCTCATTGACTGTTATTTCAGTAAAGGCCGTCTCAGGCATGATCACTTTTTCTGTGATGGATAAAATGCAACTAACTTACCC
CATTTTCTATATCATGTTTATCATCATGATAGCATCTTGTGTTTTCCAAGTCAAGTTCCTGAATCAAGCCACGAAACTCTACAATACGAC
AACAGTGGTGCCAGTTAATCATATTTTCTTTACAATCAGTGCCATCATTGCAGGTATCATATTTTATCAGGAATTCCTTGGTGCTCCTTT
TCTCACTGTATTTATATATCTTTTTGGGTGTTTTCTGTCATTCCTTGGTGTATTTTTGGTCACAAGAAATCGAGAAAAGGAACATCTGCA
ACAGTCTTATATTGATTTTGGAAATATTCCTGACACAACCCCAGAGAGAAAGGCTTGGAGGGAAACAAATGTTGGACAAAATACAACCAG
ATTCACATAGCTTATCCTATGGAACTTTGCCTGATGGAAGTGACTCAACAAAGAGCCAAAGTGGAGAGAAGAAAGAGGTCTAAATGCTGA
GAAGGATGGCTGTTGGCCTGTTATTCGATACCACCTTTTTAAAAAATTGCACATGTTCAATTTGTGTCAGCAGCTCTTTTATAAGCTAAC
ATGTGCTAGCATTCATTTCAGTCCTTTCCCCCACCTCAGCGTCTATGGACAATCGGGGACTTCCTAAGCTCTGACAGTCTAATATTTCCA
TGGAATGTGATTTGGAGTGTTCCCCACACCCTGGACCTCTCCCTAGTGATTATCTAGCCAGCTACACCTTACTCAGAGCCCGGCTGCTCT
AGCAGGAATGTTGCACAGAAACATACATTTGCGGTTTGGCCACAGGTCGCATAGGTGGCTTCTCCCACGGGTAGTGTCAGTTGCTTCACT
TTAAAAAGTCACTTCAGCCCCACAACCTCACTCCCAAAAGAAAGGTTTGAGAGCGCTCATTTTTTTTCTAAGACACCTTTTATAAGCCTC
CCTATAAAAATCTCACCTTTCAAGTACTAAGTTAGAATTGCAAGTCATCTTTTCTGAAAACTAATGCTATCAAAGTCCTCCTTTGAAAAT
TAAGGGTCTCTTTAAAATTAGAATTTATAAATGGCATTCAGTGATAGTGTACACCAAAATTAAAAGACCTTGACTGGTGGGCTTTTTACG
TGTAAGGAAGAGGAAGTTTAAGAAGTAGGACTCTGCTTGTTTCAGTAGCCCATGTACTAAAATAGGAACAATGCAGAGATTAGCACAGCC
CCTGCACAAGGCTGACACATAAATTCATGAAGCGTTAGAGACAAAAAGTAGGACTAATGTTTGTTTATTTTTTAATAAAAATCTAGAATG
GTGATGTTTTCTTCAGCTGTATGATTCTATCATACTTGAAACTGAAGAAAAATTTAATATCCTATGTCTTTTTTATAGATCTTATAATTT
ATCAAGTGGATTTATATGTCTTATTCTCCATATAAGTCTAAAAAATCACATTTAAATTCTTAGTGATAGTTTCACTACACATCATTTCTT
CCCAAAGTCATTACCTCAAGCTTTGTAAATTCTTCTAGATAAAAGGAGAGTTGTGATTAGAGAACTGAATTTCAGCCATTTAAACCTGTA
GACATAGAAAACAACCCAGTGGTCAAACCTGAGCTTCAAGAGGAAGCCCAAGTCCTCCTGTTTCCTGAATGGCTTTTCCACTCCAATTCA
TCACATATCTGCTAAGACACATTTGCAGGTAGAATCCATAATAATATCTGTTATTTATGATCTACCTAATATTTAAAGGAGAAGAAAAGA
AGTAGCCTTCGTTGCAGCCAACATCCAACAATAAGTCCCACCCTTAATGACATTTCAAAGCCTTCAGATCACTTCTGACATGTCTGTCCA
ATATCATTCCAATCAATAGTCTTGCATTTAAATAGGTTGTTTAACTCGGTGGTATTGAGACTGTAACCTTAATGGCTCAGGTCTTTTAGC
TTTGTTCTTTGTCATAATCTGCACTCCTGGCCAGACTGACCAAACCTGGCTGCAAAGGAAAGAGATTTGAATTGATCACCAATGTATGAA
AAATACAGAACCCATGTCTGGCTCCTAAACTCCTGGTAATAATTCCCGCCATCGTAGCAAGTGTCCCATGCATTCAGATAAAGCAGTCAT
AATTTATGGTGTATTTTACCGAATTGGTCCAGCATATTGGTCCTACAAGGCTCAGCCAAGAAATGTATCTGGTGCCTTAAACTACAGATT
TCTGGTGACTCTTAAAACTGGTTTACAAAGATTGAGAAAACAATTAGATTGAAGAGTTTTGCTTCAAGTAGACCTGCATTCATAGCTAGA
GTGCATGAGATTTTCAGCACTGTAGAATTTCACACAGGCACAAGCATAACACCAGTACTTTAGCAGCCGCCAACAGTTGCATCTATTAAA
CGTTTTGAGAAATGACATTGACTTATGCACATTTAAGCAATCAACAATGTTTTAGAAGTCCAGGTAACATATAAAATATATTCAGACCTA
GTTTTACTTTCCATATTGTTGCTCCAAAGTAAGGTAAATAGGAGTTTTAGTTGTACTGGCCTGTAAGATTTTTTAAATTACACAGTGCAT
GACAACAACTAAAGCCAACTCAGTCCTTCTCTTGGCATTGTGAGTTGAGGACCTTTAGCCAACTGTTAGCTCATCTGACTATCTGTCTAG
ACCAAGGGTCGGCAAAGTTTTCAGTAAAGACCCACAGAGTACATATTTTGGAGTTTGTGTTGTCTGTACCAACAGACAGACATGGTGTCT
GTCCCAACTACCCAACTCTGCCATTGTAGCACTAAAGCAGCCATAGACAAGATGTAAACAGAAGAGCATGGCTGTGTTCCAGTAAAACTT
TATTTACAGGCCAGGCATGGTGGCTCATGCCTGTAATCCCAGCACTCTGGGAGGCTGAGGCTGACAGATCATCTGAGGTTAGGAGTTTGG
GACCAGCCTGGTCAACATAGTGAAACCCCATCTCTACTAAAAGTACAAAAATTAGCCAGGCATGACGGTGGGTGCCTGGAGTCCCAGCTA
CCTGGGAGGCTGAGGCAGGAGAATCACTTGAACCCGGGAGGTGGAGGTTGCAGTGAGCCGAGATCATGCCATTGCACTCCAGCCTGGGCG
ACAGAGTAAGACTGTCTCAAAAACAAACAAACAAACAAACAAACAAAAACAAGTGGCCAGTCTGTGAGCTATAGTTCCCAACACCTGGTC
TAGACTCTTCTGCCCTTGCTCTGCAGCTTCTTTCCTGTTGATTGGGCATTCAGGGAAGGAGTTTAAAAAGTGACACTCATGGCTCATGAC
AAATGAGATACTTTGGGAGTGTGGAAACATGGCTTGATATTTGCCTTCAGATATTTTTGCTTATATAAGTTCTAAATGGAAGTGATAAGT
TCATTCTTAGGGTCCAAGTTGAAAGGCAGTGGTTCTTTTGTGAACACCACTAACTACATTCGAAAAGCCTCTCCAATTCCACATTCCAAG
TCTATAACAGCTTTGGAAATGAGTAACAATGACCTCTCATGTAGTAGATTAAAGCAGAGGCCTTTGCCATATGATTGTTTTTTGGCTTAA

>73820_73820_3_RGS22-NIPAL2_RGS22_chr8_101059691_ENST00000523437_NIPAL2_chr8_99266315_ENST00000341166_length(amino acids)=606AA_BP=
MPEKRLTAEPPTITEEEFEDSLATDDFLVDYFNEFLSLPTFSEAIRFNADYGVFEVANDAPQFLEKQLKKILQNQQPRNPIYDVVRKGKN
EVKPVQMNAPDEDETINVNYNIMCLSREEGIKWIKKERLPAFLESDCYFEYRLAKLVSQVRWSKSGMNFTVGSNFSPWIVKKPPSLPPPA
TEEDNLASYTQTKDWFALAKQSQQTVSTFSLPCCVPYNKLKSPAISSVSENFIFDDGVHPRTKKDPSKTNKLISEFEEEEGEEEEVSVSL
QDTPSQALLRVYLEKKQDVDESLTMHFSTCEEFLSSYIYFILRGAIQQIVGKPVGETPDYINFNNITKVSFDDCFESIHGKNFLSELVQT
TKERSEEIEQTSLSSKNESAGPESRADWCISHRTYDIGNRKEFERFKKFIKGTLGERYWWLWMDIERLKVLKDPGRHQRHLEKMKKCYLV
SNGDYYLSAEILSKFKLLDGSQWNEEHLRNIQSEVLKPLLLYWAPRFCVTHSASTKYASAELKFWHLRQAKPRKDIDPFPQMATLLPLRP

--------------------------------------------------------------
>73820_73820_4_RGS22-NIPAL2_RGS22_chr8_101059691_ENST00000523437_NIPAL2_chr8_99266315_ENST00000430223_length(transcript)=5990nt_BP=1828nt
GACGGCCCGCGCGGGCTCCAGGCGCGGGCAGCGGGGACGGCATGCCCGAGAAGAGGCTCACCGCGGAGCCACCAACTATTACAGAAGAAG
AATTTGAAGATTCTCTGGCAACAGATGATTTCCTTGTAGACTACTTTAATGAATTCCTAAGCCTTCCAACCTTTTCAGAGGCAATTAGAT
TTAATGCAGATTATGGAGTTTTTGAAGTAGCTAATGATGCTCCACAATTTCTGGAAAAACAACTGAAAAAAATTCTACAAAACCAGCAAC
CTCGAAATCCCATTTATGATGTTGTAAGGAAAGGAAAGAATGAGGTTAAACCTGTTCAAATGAATGCCCCCGATGAAGATGAGACCATTA
ATGTCAACTACAATATTATGTGTCTCAGTCGTGAAGAAGGTATTAAGTGGATCAAAAAAGAAAGACTTCCAGCATTTCTGGAAAGTGATT
GTTACTTTGAATACAGGTTAGCCAAATTGGTCTCACAAGTAAGATGGAGCAAGTCCGGCATGAATTTCACAGTAGGATCAAATTTTTCTC
CCTGGATCGTGAAAAAACCACCCAGTCTACCACCTCCTGCCACTGAAGAAGATAATCTTGCTTCCTATACTCAAACAAAAGATTGGTTTG
CATTAGCAAAACAAAGTCAGCAAACAGTATCAACCTTTTCGTTACCCTGTTGTGTACCCTACAACAAACTTAAATCACCAGCTATTTCAT
CTGTTTCTGAGAATTTTATCTTTGATGATGGAGTTCACCCTAGGACAAAAAAGGACCCATCTAAAACCAACAAATTGATTTCTGAATTTG
AAGAAGAAGAAGGAGAAGAAGAAGAGGTGTCTGTATCTCTACAAGACACTCCTTCTCAAGCTCTTCTGAGAGTATACCTTGAAAAGAAAC
AGGATGTTGATGAAAGCCTGACAATGCATTTCTCAACATGTGAAGAATTTTTAAGCTCCTATATATACTTTATTTTGAGAGGAGCAATTC
AGCAAATTGTTGGAAAGCCAGTTGGAGAAACCCCAGACTATATAAACTTCAACAATATAACAAAAGTGTCATTTGATGATTGTTTTGAGT
CTATTCATGGCAAGAATTTTTTAAGTGAATTAGTTCAAACTACAAAGGAGAGGTCAGAAGAGATAGAACAAACAAGTTTAAGTTCAAAGA
ATGAGAGCGCTGGACCAGAGAGCAGGGCGGACTGGTGTATTTCTCATAGGACTTATGACATTGGCAATAGAAAGGAGTTTGAAAGATTTA
AGAAATTTATAAAAGGTACATTGGGAGAGAGATATTGGTGGCTATGGATGGATATTGAGAGGTTAAAAGTTCTTAAGGATCCTGGAAGAC
ATCAAAGACATCTTGAGAAGATGAAAAAATGCTATCTAGTGAGCAATGGAGATTACTACCTTTCTGCAGAAATCTTATCAAAATTTAAAC
TGTTAGATGGATCACAGTGGAATGAAGAGCATTTAAGAAATATTCAGTCTGAAGTTTTAAAACCTTTACTTCTGTATTGGGCACCAAGAT
TCTGTGTTACTCATTCAGCCTCAACAAAATATGCTAGTGCTGAACTGAAATTCTGGCACCTCCGTCAAGCAAAACCAAGGAAGGATATTG
ACCCTTTTCCACAAATGGCAACCCTCTTGCCATTAAGACCCAAATCTTGCATTCCACAGATACCTGAGATCCAGAAAGAAGAATTCAGCT
TATCACAACCTCCTAAATCTCCCAATAAATCACCTGAAGTAAAAACAGCAACTCAAAAGCCTTGGAAGCGGGAGCTTTTGTATCCAGGTT
CTTCTAAGGATGATGTGATTGAGAAAGGATTCACCTTTTTGGAGTTTTGCTGGCTATTTTAGGAAACTTGGTGATCAGTATTTCTCTAAA
TATTCAGAAATATTCTCACCTTCAGCTGGCACAACAAGAGCACCCAAGGCCATACTTCAAGAGTGTGCTGTGGTGGGGTGGTGTCCTGCT
GATGGCCGTGGGAGAGACGGGGAACTTTGCAGCCTATGGATTTGCTCCCATTACTCTGATCGCTCCGTTAGGCTGTGTGTCTGTTACAGG
TAGTGCCATTATTTCTGTTACATTTCTGAAAGACAATTTGAGAGCCTCAGACTTACTCGGTACGACACTGGCATTTGCAGGAACATATTT
ACTGGTGAACTTTGCTCCAAATATAACTCAGGCAATCTCAGCAAGAACAGTACAGTATTACCTTGTCGGATGGCAGTTCCTGATCTATGT
GATTTTAGAAATATTAATTTTCTGCATTCTCCTGTATTTCTATAAAAGAAAAGGAATGAAGCATATGGTGATTCTGCTAACCCTGGTGGC
AATTCTAGCCTCATTGACTGTTATTTCAGTAAAGGCCGTCTCAGGCATGATCACTTTTTCTGTGATGGATAAAATGCAACTAACTTACCC
CATTTTCTATATCATGTTTATCATCATGATAGCATCTTGTGTTTTCCAAGTCAAGTTCCTGAATCAAGCCACGAAACTCTACAATACGAC
AACAGTGGTGCCAGTTAATCATATTTTCTTTACAATCAGTGCCATCATTGCAGGTATCATATTTTATCAGGAATTCCTTGGTGCTCCTTT
TCTCACTGTATTTATATATCTTTTTGGGTGTTTTCTGTCATTCCTTGGTGTATTTTTGGTCACAAGAAATCGAGAAAAGGAACATCTGCA
ACAGTCTTATATTGATTTTGGAAATATTCCTGGGAAACAAATGTTGGACAAAATACAACCAGATTCACATAGCTTATCCTATGGAACTTT
GCCTGATGGAAGTGACTCAACAAAGAGCCAAAGTGGAGAGAAGAAAGAGGTCTAAATGCTGAGAAGGATGGCTGTTGGCCTGTTATTCGA
TACCACCTTTTTAAAAAATTGCACATGTTCAATTTGTGTCAGCAGCTCTTTTATAAGCTAACATGTGCTAGCATTCATTTCAGTCCTTTC
CCCCACCTCAGCGTCTATGGACAATCGGGGACTTCCTAAGCTCTGACAGTCTAATATTTCCATGGAATGTGATTTGGAGTGTTCCCCACA
CCCTGGACCTCTCCCTAGTGATTATCTAGCCAGCTACACCTTACTCAGAGCCCGGCTGCTCTAGCAGGAATGTTGCACAGAAACATACAT
TTGCGGTTTGGCCACAGGTCGCATAGGTGGCTTCTCCCACGGGTAGTGTCAGTTGCTTCACTTTAAAAAGTCACTTCAGCCCCACAACCT
CACTCCCAAAAGAAAGGTTTGAGAGCGCTCATTTTTTTTCTAAGACACCTTTTATAAGCCTCCCTATAAAAATCTCACCTTTCAAGTACT
AAGTTAGAATTGCAAGTCATCTTTTCTGAAAACTAATGCTATCAAAGTCCTCCTTTGAAAATTAAGGGTCTCTTTAAAATTAGAATTTAT
AAATGGCATTCAGTGATAGTGTACACCAAAATTAAAAGACCTTGACTGGTGGGCTTTTTACGTGTAAGGAAGAGGAAGTTTAAGAAGTAG
GACTCTGCTTGTTTCAGTAGCCCATGTACTAAAATAGGAACAATGCAGAGATTAGCACAGCCCCTGCACAAGGCTGACACATAAATTCAT
GAAGCGTTAGAGACAAAAAGTAGGACTAATGTTTGTTTATTTTTTAATAAAAATCTAGAATGGTGATGTTTTCTTCAGCTGTATGATTCT
ATCATACTTGAAACTGAAGAAAAATTTAATATCCTATGTCTTTTTTATAGATCTTATAATTTATCAAGTGGATTTATATGTCTTATTCTC
CATATAAGTCTAAAAAATCACATTTAAATTCTTAGTGATAGTTTCACTACACATCATTTCTTCCCAAAGTCATTACCTCAAGCTTTGTAA
ATTCTTCTAGATAAAAGGAGAGTTGTGATTAGAGAACTGAATTTCAGCCATTTAAACCTGTAGACATAGAAAACAACCCAGTGGTCAAAC
CTGAGCTTCAAGAGGAAGCCCAAGTCCTCCTGTTTCCTGAATGGCTTTTCCACTCCAATTCATCACATATCTGCTAAGACACATTTGCAG
GTAGAATCCATAATAATATCTGTTATTTATGATCTACCTAATATTTAAAGGAGAAGAAAAGAAGTAGCCTTCGTTGCAGCCAACATCCAA
CAATAAGTCCCACCCTTAATGACATTTCAAAGCCTTCAGATCACTTCTGACATGTCTGTCCAATATCATTCCAATCAATAGTCTTGCATT
TAAATAGGTTGTTTAACTCGGTGGTATTGAGACTGTAACCTTAATGGCTCAGGTCTTTTAGCTTTGTTCTTTGTCATAATCTGCACTCCT
GGCCAGACTGACCAAACCTGGCTGCAAAGGAAAGAGATTTGAATTGATCACCAATGTATGAAAAATACAGAACCCATGTCTGGCTCCTAA
ACTCCTGGTAATAATTCCCGCCATCGTAGCAAGTGTCCCATGCATTCAGATAAAGCAGTCATAATTTATGGTGTATTTTACCGAATTGGT
CCAGCATATTGGTCCTACAAGGCTCAGCCAAGAAATGTATCTGGTGCCTTAAACTACAGATTTCTGGTGACTCTTAAAACTGGTTTACAA
AGATTGAGAAAACAATTAGATTGAAGAGTTTTGCTTCAAGTAGACCTGCATTCATAGCTAGAGTGCATGAGATTTTCAGCACTGTAGAAT
TTCACACAGGCACAAGCATAACACCAGTACTTTAGCAGCCGCCAACAGTTGCATCTATTAAACGTTTTGAGAAATGACATTGACTTATGC
ACATTTAAGCAATCAACAATGTTTTAGAAGTCCAGGTAACATATAAAATATATTCAGACCTAGTTTTACTTTCCATATTGTTGCTCCAAA
GTAAGGTAAATAGGAGTTTTAGTTGTACTGGCCTGTAAGATTTTTTAAATTACACAGTGCATGACAACAACTAAAGCCAACTCAGTCCTT
CTCTTGGCATTGTGAGTTGAGGACCTTTAGCCAACTGTTAGCTCATCTGACTATCTGTCTAGACCAAGGGTCGGCAAAGTTTTCAGTAAA
GACCCACAGAGTACATATTTTGGAGTTTGTGTTGTCTGTACCAACAGACAGACATGGTGTCTGTCCCAACTACCCAACTCTGCCATTGTA
GCACTAAAGCAGCCATAGACAAGATGTAAACAGAAGAGCATGGCTGTGTTCCAGTAAAACTTTATTTACAGGCCAGGCATGGTGGCTCAT
GCCTGTAATCCCAGCACTCTGGGAGGCTGAGGCTGACAGATCATCTGAGGTTAGGAGTTTGGGACCAGCCTGGTCAACATAGTGAAACCC
CATCTCTACTAAAAGTACAAAAATTAGCCAGGCATGACGGTGGGTGCCTGGAGTCCCAGCTACCTGGGAGGCTGAGGCAGGAGAATCACT
TGAACCCGGGAGGTGGAGGTTGCAGTGAGCCGAGATCATGCCATTGCACTCCAGCCTGGGCGACAGAGTAAGACTGTCTCAAAAACAAAC
AAACAAACAAACAAACAAAAACAAGTGGCCAGTCTGTGAGCTATAGTTCCCAACACCTGGTCTAGACTCTTCTGCCCTTGCTCTGCAGCT
TCTTTCCTGTTGATTGGGCATTCAGGGAAGGAGTTTAAAAAGTGACACTCATGGCTCATGACAAATGAGATACTTTGGGAGTGTGGAAAC
ATGGCTTGATATTTGCCTTCAGATATTTTTGCTTATATAAGTTCTAAATGGAAGTGATAAGTTCATTCTTAGGGTCCAAGTTGAAAGGCA
GTGGTTCTTTTGTGAACACCACTAACTACATTCGAAAAGCCTCTCCAATTCCACATTCCAAGTCTATAACAGCTTTGGAAATGAGTAACA
ATGACCTCTCATGTAGTAGATTAAAGCAGAGGCCTTTGCCATATGATTGTTTTTTGGCTTAAATGTTTGCTTGCCCTGTAACTGTAATAC

>73820_73820_4_RGS22-NIPAL2_RGS22_chr8_101059691_ENST00000523437_NIPAL2_chr8_99266315_ENST00000430223_length(amino acids)=606AA_BP=
MPEKRLTAEPPTITEEEFEDSLATDDFLVDYFNEFLSLPTFSEAIRFNADYGVFEVANDAPQFLEKQLKKILQNQQPRNPIYDVVRKGKN
EVKPVQMNAPDEDETINVNYNIMCLSREEGIKWIKKERLPAFLESDCYFEYRLAKLVSQVRWSKSGMNFTVGSNFSPWIVKKPPSLPPPA
TEEDNLASYTQTKDWFALAKQSQQTVSTFSLPCCVPYNKLKSPAISSVSENFIFDDGVHPRTKKDPSKTNKLISEFEEEEGEEEEVSVSL
QDTPSQALLRVYLEKKQDVDESLTMHFSTCEEFLSSYIYFILRGAIQQIVGKPVGETPDYINFNNITKVSFDDCFESIHGKNFLSELVQT
TKERSEEIEQTSLSSKNESAGPESRADWCISHRTYDIGNRKEFERFKKFIKGTLGERYWWLWMDIERLKVLKDPGRHQRHLEKMKKCYLV
SNGDYYLSAEILSKFKLLDGSQWNEEHLRNIQSEVLKPLLLYWAPRFCVTHSASTKYASAELKFWHLRQAKPRKDIDPFPQMATLLPLRP

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Fusion Gene PPI Analysis for RGS22-NIPAL2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for RGS22-NIPAL2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for RGS22-NIPAL2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source