FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:RHBDL3-CTLA4 (FusionGDB2 ID:73892)

Fusion Gene Summary for RHBDL3-CTLA4

check button Fusion gene summary
Fusion gene informationFusion gene name: RHBDL3-CTLA4
Fusion gene ID: 73892
HgeneTgene
Gene symbol

RHBDL3

CTLA4

Gene ID

162494

1493

Gene namerhomboid like 3cytotoxic T-lymphocyte associated protein 4
SynonymsRHBDL4|VRHOALPS5|CD|CD152|CELIAC3|CTLA-4|GRD4|GSE|IDDM12
Cytomap

17q11.2

2q33.2

Type of geneprotein-codingprotein-coding
Descriptionrhomboid-related protein 3rhomboid, veinlet-like 3rhomboid, veinlet-like 4ventrhoid transmembrane proteincytotoxic T-lymphocyte protein 4CD152 isoformceliac disease 3cytotoxic T lymphocyte associated antigen 4 short spliced formcytotoxic T-lymphocyte-associated serine esterase-4insulin-dependent diabetes mellitus 12ligand and transmembrane spliced cyto
Modification date2020031320200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000269051, ENST00000536287, 
ENST00000538145, 		ENST00000427473, 
ENST00000487393, ENST00000295854, 
ENST00000302823, ENST00000472206, 
Fusion gene scores* DoF score2 X 2 X 2=82 X 1 X 2=4
# samples 22
** MAII scorelog2(2/8*10)=1.32192809488736log2(2/4*10)=2.32192809488736
Context

PubMed: RHBDL3 [Title/Abstract] AND CTLA4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRHBDL3(30625223)-CTLA4(204735309), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCTLA4

GO:0045590

negative regulation of regulatory T cell differentiation

18641304


check buttonFusion gene breakpoints across RHBDL3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CTLA4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-19-A60I-01ARHBDL3chr17

30625223

+CTLA4chr2

204735309

+


Top

Fusion Gene ORF analysis for RHBDL3-CTLA4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000269051ENST00000427473RHBDL3chr17

30625223

+CTLA4chr2

204735309

+
5CDS-5UTRENST00000536287ENST00000427473RHBDL3chr17

30625223

+CTLA4chr2

204735309

+
5CDS-5UTRENST00000538145ENST00000427473RHBDL3chr17

30625223

+CTLA4chr2

204735309

+
5CDS-intronENST00000269051ENST00000487393RHBDL3chr17

30625223

+CTLA4chr2

204735309

+
5CDS-intronENST00000536287ENST00000487393RHBDL3chr17

30625223

+CTLA4chr2

204735309

+
5CDS-intronENST00000538145ENST00000487393RHBDL3chr17

30625223

+CTLA4chr2

204735309

+
In-frameENST00000269051ENST00000295854RHBDL3chr17

30625223

+CTLA4chr2

204735309

+
In-frameENST00000269051ENST00000302823RHBDL3chr17

30625223

+CTLA4chr2

204735309

+
In-frameENST00000269051ENST00000472206RHBDL3chr17

30625223

+CTLA4chr2

204735309

+
In-frameENST00000536287ENST00000295854RHBDL3chr17

30625223

+CTLA4chr2

204735309

+
In-frameENST00000536287ENST00000302823RHBDL3chr17

30625223

+CTLA4chr2

204735309

+
In-frameENST00000536287ENST00000472206RHBDL3chr17

30625223

+CTLA4chr2

204735309

+
In-frameENST00000538145ENST00000295854RHBDL3chr17

30625223

+CTLA4chr2

204735309

+
In-frameENST00000538145ENST00000302823RHBDL3chr17

30625223

+CTLA4chr2

204735309

+
In-frameENST00000538145ENST00000472206RHBDL3chr17

30625223

+CTLA4chr2

204735309

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000269051RHBDL3chr1730625223+ENST00000302823CTLA4chr2204735309+2506795141357447
ENST00000269051RHBDL3chr1730625223+ENST00000295854CTLA4chr2204735309+1211795141210399
ENST00000269051RHBDL3chr1730625223+ENST00000472206CTLA4chr2204735309+96379514925303
ENST00000538145RHBDL3chr1730625223+ENST00000302823CTLA4chr2204735309+2481770131332439
ENST00000538145RHBDL3chr1730625223+ENST00000295854CTLA4chr2204735309+1186770131185391
ENST00000538145RHBDL3chr1730625223+ENST00000472206CTLA4chr2204735309+93877013900295
ENST00000536287RHBDL3chr1730625223+ENST00000302823CTLA4chr2204735309+2320609741171365
ENST00000536287RHBDL3chr1730625223+ENST00000295854CTLA4chr2204735309+1025609741024317
ENST00000536287RHBDL3chr1730625223+ENST00000472206CTLA4chr2204735309+77760974739221

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000269051ENST00000302823RHBDL3chr1730625223+CTLA4chr2204735309+0.0008436420.99915636
ENST00000269051ENST00000295854RHBDL3chr1730625223+CTLA4chr2204735309+0.005157470.9948426
ENST00000269051ENST00000472206RHBDL3chr1730625223+CTLA4chr2204735309+0.0086826620.9913174
ENST00000538145ENST00000302823RHBDL3chr1730625223+CTLA4chr2204735309+0.0010296010.9989704
ENST00000538145ENST00000295854RHBDL3chr1730625223+CTLA4chr2204735309+0.0060726620.99392736
ENST00000538145ENST00000472206RHBDL3chr1730625223+CTLA4chr2204735309+0.0096633140.99033666
ENST00000536287ENST00000302823RHBDL3chr1730625223+CTLA4chr2204735309+0.0008764570.9991235
ENST00000536287ENST00000295854RHBDL3chr1730625223+CTLA4chr2204735309+0.0031028460.9968971
ENST00000536287ENST00000472206RHBDL3chr1730625223+CTLA4chr2204735309+0.0183674280.9816326

Top

Fusion Genomic Features for RHBDL3-CTLA4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RHBDL3chr1730625223+CTLA4chr2204735308+6.93E-060.9999931
RHBDL3chr1730625223+CTLA4chr2204735308+6.93E-060.9999931

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for RHBDL3-CTLA4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:30625223/chr2:204735309)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRHBDL3chr17:30625223chr2:204735309ENST00000269051+6934_69260405.0DomainEF-hand 1
HgeneRHBDL3chr17:30625223chr2:204735309ENST00000269051+6970_105260405.0DomainEF-hand 2
HgeneRHBDL3chr17:30625223chr2:204735309ENST00000269051+69164_184260405.0TransmembraneHelical
HgeneRHBDL3chr17:30625223chr2:204735309ENST00000269051+69218_238260405.0TransmembraneHelical
TgeneCTLA4chr17:30625223chr2:204735309ENST000002958540339_14036175.0DomainNote=Ig-like V-type
TgeneCTLA4chr17:30625223chr2:204735309ENST000003028230439_14036224.0DomainNote=Ig-like V-type
TgeneCTLA4chr17:30625223chr2:204735309ENST000004274730339_1400138.0DomainNote=Ig-like V-type
TgeneCTLA4chr17:30625223chr2:204735309ENST000004722060339_1403680.0DomainNote=Ig-like V-type
TgeneCTLA4chr17:30625223chr2:204735309ENST0000029585403150_15536175.0RegionHomodimerization
TgeneCTLA4chr17:30625223chr2:204735309ENST000002958540346_5036175.0RegionHomodimerization
TgeneCTLA4chr17:30625223chr2:204735309ENST0000030282304150_15536224.0RegionHomodimerization
TgeneCTLA4chr17:30625223chr2:204735309ENST000003028230446_5036224.0RegionHomodimerization
TgeneCTLA4chr17:30625223chr2:204735309ENST0000042747303150_1550138.0RegionHomodimerization
TgeneCTLA4chr17:30625223chr2:204735309ENST000004274730346_500138.0RegionHomodimerization
TgeneCTLA4chr17:30625223chr2:204735309ENST0000047220603150_1553680.0RegionHomodimerization
TgeneCTLA4chr17:30625223chr2:204735309ENST000004722060346_503680.0RegionHomodimerization
TgeneCTLA4chr17:30625223chr2:204735309ENST0000029585403183_22336175.0Topological domainCytoplasmic
TgeneCTLA4chr17:30625223chr2:204735309ENST000002958540336_16136175.0Topological domainExtracellular
TgeneCTLA4chr17:30625223chr2:204735309ENST0000030282304183_22336224.0Topological domainCytoplasmic
TgeneCTLA4chr17:30625223chr2:204735309ENST000003028230436_16136224.0Topological domainExtracellular
TgeneCTLA4chr17:30625223chr2:204735309ENST0000042747303183_2230138.0Topological domainCytoplasmic
TgeneCTLA4chr17:30625223chr2:204735309ENST000004274730336_1610138.0Topological domainExtracellular
TgeneCTLA4chr17:30625223chr2:204735309ENST0000047220603183_2233680.0Topological domainCytoplasmic
TgeneCTLA4chr17:30625223chr2:204735309ENST000004722060336_1613680.0Topological domainExtracellular
TgeneCTLA4chr17:30625223chr2:204735309ENST0000029585403162_18236175.0TransmembraneHelical
TgeneCTLA4chr17:30625223chr2:204735309ENST0000030282304162_18236224.0TransmembraneHelical
TgeneCTLA4chr17:30625223chr2:204735309ENST0000042747303162_1820138.0TransmembraneHelical
TgeneCTLA4chr17:30625223chr2:204735309ENST0000047220603162_1823680.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRHBDL3chr17:30625223chr2:204735309ENST00000269051+69250_270260405.0TransmembraneHelical
HgeneRHBDL3chr17:30625223chr2:204735309ENST00000269051+69274_294260405.0TransmembraneHelical
HgeneRHBDL3chr17:30625223chr2:204735309ENST00000269051+69303_325260405.0TransmembraneHelical
HgeneRHBDL3chr17:30625223chr2:204735309ENST00000269051+69338_358260405.0TransmembraneHelical
HgeneRHBDL3chr17:30625223chr2:204735309ENST00000269051+69371_391260405.0TransmembraneHelical


Top

Fusion Gene Sequence for RHBDL3-CTLA4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>73892_73892_1_RHBDL3-CTLA4_RHBDL3_chr17_30625223_ENST00000269051_CTLA4_chr2_204735309_ENST00000295854_length(transcript)=1211nt_BP=795nt
ACCCCGTCTCGGCCATGGGCGAGCACCCCAGCCCGGGCCCCGCGGTGGCCGCCTGCGCCGAGGCGGAGCGCATCGAGGAGCTGGAACCCG
AGGCCGAGGAGCGGCTGCCCGCGGCGCCGGAGGACCACTGGAAAGTCCTGTTTGATCAGTTTGACCCTGGGAACACAGGCTACATTAGCA
CAGGCAAGTTCCGGAGTCTTCTGGAGAGCCACAGCTCCAAGCTGGACCCGCACAAAAGGGAGGTCCTCCTGGCTCTTGCCGACAGCCACG
CGGATGGGCAGATCGGCTACCAGGATTTTGTCAGCCTAATGAGCAACAAGCGTTCCAACAGCTTCCGCCAAGCCATCCTGCAGGGCAACC
GCAGGCTAAGCAGCAAGGCCCTGCTGGAGGAGAAGGGGCTGAGCCTCTCGCAGCGACTTATCCGCCATGTGGCCTATGAGACCCTGCCCC
GGGAAATTGACCGCAAGTGGTACTATGACAGCTACACCTGCTGCCCCCCACCCTGGTTCATGATCACAGTCACGCTGCTGGAGGTTGCCT
TTTTCCTCTACAATGGGGTGTCACTAGGTCAATTTGTACTGCAGGTAACTCATCCACGTTACTTGAAGAACTCCCTGGTTTACCACCCAC
AGCTGCGAGCACAGGTTTGGCGCTACCTGACATACATCTTCATGCATGCAGGGATAGAACACCTGGGACTCAATGTGGTGCTGCAGCTGC
TGGTGGGGGTGCCCCTGGAGATGGTGCATGGAGCCACCCGAATTGGGCTTGTCTACGTGGCCGGTGTTGTGGCAGCAATGCACGTGGCCC
AGCCTGCTGTGGTACTGGCCAGCAGCCGAGGCATCGCCAGCTTTGTGTGTGAGTATGCATCTCCAGGCAAAGCCACTGAGGTCCGGGTGA
CAGTGCTTCGGCAGGCTGACAGCCAGGTGACTGAAGTCTGTGCGGCAACCTACATGATGGGGAATGAGTTGACCTTCCTAGATGATTCCA
TCTGCACGGGCACCTCCAGTGGAAATCAAGTGAACCTCACTATCCAAGGACTGAGGGCCATGGACACGGGACTCTACATCTGCAAGGTGG
AGCTCATGTACCCACCGCCATACTACCTGGGCATAGGCAACGGAACCCAGATTTATGTAATTGCTAAAGAAAAGAAGCCCTCTTACAACA

>73892_73892_1_RHBDL3-CTLA4_RHBDL3_chr17_30625223_ENST00000269051_CTLA4_chr2_204735309_ENST00000295854_length(amino acids)=399AA_BP=260
MGEHPSPGPAVAACAEAERIEELEPEAEERLPAAPEDHWKVLFDQFDPGNTGYISTGKFRSLLESHSSKLDPHKREVLLALADSHADGQI
GYQDFVSLMSNKRSNSFRQAILQGNRRLSSKALLEEKGLSLSQRLIRHVAYETLPREIDRKWYYDSYTCCPPPWFMITVTLLEVAFFLYN
GVSLGQFVLQVTHPRYLKNSLVYHPQLRAQVWRYLTYIFMHAGIEHLGLNVVLQLLVGVPLEMVHGATRIGLVYVAGVVAAMHVAQPAVV
LASSRGIASFVCEYASPGKATEVRVTVLRQADSQVTEVCAATYMMGNELTFLDDSICTGTSSGNQVNLTIQGLRAMDTGLYICKVELMYP

--------------------------------------------------------------
>73892_73892_2_RHBDL3-CTLA4_RHBDL3_chr17_30625223_ENST00000269051_CTLA4_chr2_204735309_ENST00000302823_length(transcript)=2506nt_BP=795nt
ACCCCGTCTCGGCCATGGGCGAGCACCCCAGCCCGGGCCCCGCGGTGGCCGCCTGCGCCGAGGCGGAGCGCATCGAGGAGCTGGAACCCG
AGGCCGAGGAGCGGCTGCCCGCGGCGCCGGAGGACCACTGGAAAGTCCTGTTTGATCAGTTTGACCCTGGGAACACAGGCTACATTAGCA
CAGGCAAGTTCCGGAGTCTTCTGGAGAGCCACAGCTCCAAGCTGGACCCGCACAAAAGGGAGGTCCTCCTGGCTCTTGCCGACAGCCACG
CGGATGGGCAGATCGGCTACCAGGATTTTGTCAGCCTAATGAGCAACAAGCGTTCCAACAGCTTCCGCCAAGCCATCCTGCAGGGCAACC
GCAGGCTAAGCAGCAAGGCCCTGCTGGAGGAGAAGGGGCTGAGCCTCTCGCAGCGACTTATCCGCCATGTGGCCTATGAGACCCTGCCCC
GGGAAATTGACCGCAAGTGGTACTATGACAGCTACACCTGCTGCCCCCCACCCTGGTTCATGATCACAGTCACGCTGCTGGAGGTTGCCT
TTTTCCTCTACAATGGGGTGTCACTAGGTCAATTTGTACTGCAGGTAACTCATCCACGTTACTTGAAGAACTCCCTGGTTTACCACCCAC
AGCTGCGAGCACAGGTTTGGCGCTACCTGACATACATCTTCATGCATGCAGGGATAGAACACCTGGGACTCAATGTGGTGCTGCAGCTGC
TGGTGGGGGTGCCCCTGGAGATGGTGCATGGAGCCACCCGAATTGGGCTTGTCTACGTGGCCGGTGTTGTGGCAGCAATGCACGTGGCCC
AGCCTGCTGTGGTACTGGCCAGCAGCCGAGGCATCGCCAGCTTTGTGTGTGAGTATGCATCTCCAGGCAAAGCCACTGAGGTCCGGGTGA
CAGTGCTTCGGCAGGCTGACAGCCAGGTGACTGAAGTCTGTGCGGCAACCTACATGATGGGGAATGAGTTGACCTTCCTAGATGATTCCA
TCTGCACGGGCACCTCCAGTGGAAATCAAGTGAACCTCACTATCCAAGGACTGAGGGCCATGGACACGGGACTCTACATCTGCAAGGTGG
AGCTCATGTACCCACCGCCATACTACCTGGGCATAGGCAACGGAACCCAGATTTATGTAATTGATCCAGAACCGTGCCCAGATTCTGACT
TCCTCCTCTGGATCCTTGCAGCAGTTAGTTCGGGGTTGTTTTTTTATAGCTTTCTCCTCACAGCTGTTTCTTTGAGCAAAATGCTAAAGA
AAAGAAGCCCTCTTACAACAGGGGTCTATGTGAAAATGCCCCCAACAGAGCCAGAATGTGAAAAGCAATTTCAGCCTTATTTTATTCCCA
TCAATTGAGAAACCATTATGAAGAAGAGAGTCCATATTTCAATTTCCAAGAGCTGAGGCAATTCTAACTTTTTTGCTATCCAGCTATTTT
TATTTGTTTGTGCATTTGGGGGGAATTCATCTCTCTTTAATATAAAGTTGGATGCGGAACCCAAATTACGTGTACTACAATTTAAAGCAA
AGGAGTAGAAAGACAGAGCTGGGATGTTTCTGTCACATCAGCTCCACTTTCAGTGAAAGCATCACTTGGGATTAATATGGGGATGCAGCA
TTATGATGTGGGTCAAGGAATTAAGTTAGGGAATGGCACAGCCCAAAGAAGGAAAAGGCAGGGAGCGAGGGAGAAGACTATATTGTACAC
ACCTTATATTTACGTATGAGACGTTTATAGCCGAAATGATCTTTTCAAGTTAAATTTTATGCCTTTTATTTCTTAAACAAATGTATGATT
ACATCAAGGCTTCAAAAATACTCACATGGCTATGTTTTAGCCAGTGATGCTAAAGGTTGTATTGCATATATACATATATATATATATATA
TATATATATATATATATATATATATATATATATATATATTTTAATTTGATAGTATTGTGCATAGAGCCACGTATGTTTTTGTGTATTTGT
TAATGGTTTGAATATAAACACTATATGGCAGTGTCTTTCCACCTTGGGTCCCAGGGAAGTTTTGTGGAGGAGCTCAGGACACTAATACAC
CAGGTAGAACACAAGGTCATTTGCTAACTAGCTTGGAAACTGGATGAGGTCATAGCAGTGCTTGATTGCGTGGAATTGTGCTGAGTTGGT
GTTGACATGTGCTTTGGGGCTTTTACACCAGTTCCTTTCAATGGTTTGCAAGGAAGCCACAGCTGGTGGTATCTGAGTTGACTTGACAGA
ACACTGTCTTGAAGACAATGGCTTACTCCAGGAGACCCACAGGTATGACCTTCTAGGAAGCTCCAGTTCGATGGGCCCAATTCTTACAAA
CATGTGGTTAATGCCATGGACAGAAGAAGGCAGCAGGTGGCAGAATGGGGTGCATGAAGGTTTCTGAAAATTAACACTGCTTGTGTTTTT

>73892_73892_2_RHBDL3-CTLA4_RHBDL3_chr17_30625223_ENST00000269051_CTLA4_chr2_204735309_ENST00000302823_length(amino acids)=447AA_BP=260
MGEHPSPGPAVAACAEAERIEELEPEAEERLPAAPEDHWKVLFDQFDPGNTGYISTGKFRSLLESHSSKLDPHKREVLLALADSHADGQI
GYQDFVSLMSNKRSNSFRQAILQGNRRLSSKALLEEKGLSLSQRLIRHVAYETLPREIDRKWYYDSYTCCPPPWFMITVTLLEVAFFLYN
GVSLGQFVLQVTHPRYLKNSLVYHPQLRAQVWRYLTYIFMHAGIEHLGLNVVLQLLVGVPLEMVHGATRIGLVYVAGVVAAMHVAQPAVV
LASSRGIASFVCEYASPGKATEVRVTVLRQADSQVTEVCAATYMMGNELTFLDDSICTGTSSGNQVNLTIQGLRAMDTGLYICKVELMYP

--------------------------------------------------------------
>73892_73892_3_RHBDL3-CTLA4_RHBDL3_chr17_30625223_ENST00000269051_CTLA4_chr2_204735309_ENST00000472206_length(transcript)=963nt_BP=795nt
ACCCCGTCTCGGCCATGGGCGAGCACCCCAGCCCGGGCCCCGCGGTGGCCGCCTGCGCCGAGGCGGAGCGCATCGAGGAGCTGGAACCCG
AGGCCGAGGAGCGGCTGCCCGCGGCGCCGGAGGACCACTGGAAAGTCCTGTTTGATCAGTTTGACCCTGGGAACACAGGCTACATTAGCA
CAGGCAAGTTCCGGAGTCTTCTGGAGAGCCACAGCTCCAAGCTGGACCCGCACAAAAGGGAGGTCCTCCTGGCTCTTGCCGACAGCCACG
CGGATGGGCAGATCGGCTACCAGGATTTTGTCAGCCTAATGAGCAACAAGCGTTCCAACAGCTTCCGCCAAGCCATCCTGCAGGGCAACC
GCAGGCTAAGCAGCAAGGCCCTGCTGGAGGAGAAGGGGCTGAGCCTCTCGCAGCGACTTATCCGCCATGTGGCCTATGAGACCCTGCCCC
GGGAAATTGACCGCAAGTGGTACTATGACAGCTACACCTGCTGCCCCCCACCCTGGTTCATGATCACAGTCACGCTGCTGGAGGTTGCCT
TTTTCCTCTACAATGGGGTGTCACTAGGTCAATTTGTACTGCAGGTAACTCATCCACGTTACTTGAAGAACTCCCTGGTTTACCACCCAC
AGCTGCGAGCACAGGTTTGGCGCTACCTGACATACATCTTCATGCATGCAGGGATAGAACACCTGGGACTCAATGTGGTGCTGCAGCTGC
TGGTGGGGGTGCCCCTGGAGATGGTGCATGGAGCCACCCGAATTGGGCTTGTCTACGTGGCCGGTGTTGTGGCAGCAATGCACGTGGCCC
AGCCTGCTGTGGTACTGGCCAGCAGCCGAGGCATCGCCAGCTTTGTGTCTAAAGAAAAGAAGCCCTCTTACAACAGGGGTCTATGTGAAA

>73892_73892_3_RHBDL3-CTLA4_RHBDL3_chr17_30625223_ENST00000269051_CTLA4_chr2_204735309_ENST00000472206_length(amino acids)=303AA_BP=260
MGEHPSPGPAVAACAEAERIEELEPEAEERLPAAPEDHWKVLFDQFDPGNTGYISTGKFRSLLESHSSKLDPHKREVLLALADSHADGQI
GYQDFVSLMSNKRSNSFRQAILQGNRRLSSKALLEEKGLSLSQRLIRHVAYETLPREIDRKWYYDSYTCCPPPWFMITVTLLEVAFFLYN
GVSLGQFVLQVTHPRYLKNSLVYHPQLRAQVWRYLTYIFMHAGIEHLGLNVVLQLLVGVPLEMVHGATRIGLVYVAGVVAAMHVAQPAVV

--------------------------------------------------------------
>73892_73892_4_RHBDL3-CTLA4_RHBDL3_chr17_30625223_ENST00000536287_CTLA4_chr2_204735309_ENST00000295854_length(transcript)=1025nt_BP=609nt
ATGTCAGAAACATCCGAGGACTACAGAGACCTTGGTGATAAGTGTGTCTTTCTTTCTCTCCTCTTCTTCCTCTCCTGCATGGCCTCCCTC
TCTGCCAGCACTGGAAAGTCCTGTTTGATCAGATGAGCAACAAGCGTTCCAACAGCTTCCGCCAAGCCATCCTGCAGGGCAACCGCAGGC
TAAGCAGCAAGGCCCTGCTGGAGGAGAAGGGGCTGAGCCTCTCGCAGCGACTTATCCGCCATGTGGCCTATGAGACCCTGCCCCGGGAAA
TTGACCGCAAGTGGTACTATGACAGCTACACCTGCTGCCCCCCACCCTGGTTCATGATCACAGTCACGCTGCTGGAGGTTGCCTTTTTCC
TCTACAATGGGGTGTCACTAGGTCAATTTGTACTGCAGGTAACTCATCCACGTTACTTGAAGAACTCCCTGGTTTACCACCCACAGCTGC
GAGCACAGGTTTGGCGCTACCTGACATACATCTTCATGCATGCAGGGATAGAACACCTGGGACTCAATGTGGTGCTGCAGCTGCTGGTGG
GGGTGCCCCTGGAGATGGTGCATGGAGCCACCCGAATTGGGCTTGTCTACGTGGCCGGTGTTGTGGCAGCAATGCACGTGGCCCAGCCTG
CTGTGGTACTGGCCAGCAGCCGAGGCATCGCCAGCTTTGTGTGTGAGTATGCATCTCCAGGCAAAGCCACTGAGGTCCGGGTGACAGTGC
TTCGGCAGGCTGACAGCCAGGTGACTGAAGTCTGTGCGGCAACCTACATGATGGGGAATGAGTTGACCTTCCTAGATGATTCCATCTGCA
CGGGCACCTCCAGTGGAAATCAAGTGAACCTCACTATCCAAGGACTGAGGGCCATGGACACGGGACTCTACATCTGCAAGGTGGAGCTCA
TGTACCCACCGCCATACTACCTGGGCATAGGCAACGGAACCCAGATTTATGTAATTGCTAAAGAAAAGAAGCCCTCTTACAACAGGGGTC

>73892_73892_4_RHBDL3-CTLA4_RHBDL3_chr17_30625223_ENST00000536287_CTLA4_chr2_204735309_ENST00000295854_length(amino acids)=317AA_BP=178
MHGLPLCQHWKVLFDQMSNKRSNSFRQAILQGNRRLSSKALLEEKGLSLSQRLIRHVAYETLPREIDRKWYYDSYTCCPPPWFMITVTLL
EVAFFLYNGVSLGQFVLQVTHPRYLKNSLVYHPQLRAQVWRYLTYIFMHAGIEHLGLNVVLQLLVGVPLEMVHGATRIGLVYVAGVVAAM
HVAQPAVVLASSRGIASFVCEYASPGKATEVRVTVLRQADSQVTEVCAATYMMGNELTFLDDSICTGTSSGNQVNLTIQGLRAMDTGLYI

--------------------------------------------------------------
>73892_73892_5_RHBDL3-CTLA4_RHBDL3_chr17_30625223_ENST00000536287_CTLA4_chr2_204735309_ENST00000302823_length(transcript)=2320nt_BP=609nt
ATGTCAGAAACATCCGAGGACTACAGAGACCTTGGTGATAAGTGTGTCTTTCTTTCTCTCCTCTTCTTCCTCTCCTGCATGGCCTCCCTC
TCTGCCAGCACTGGAAAGTCCTGTTTGATCAGATGAGCAACAAGCGTTCCAACAGCTTCCGCCAAGCCATCCTGCAGGGCAACCGCAGGC
TAAGCAGCAAGGCCCTGCTGGAGGAGAAGGGGCTGAGCCTCTCGCAGCGACTTATCCGCCATGTGGCCTATGAGACCCTGCCCCGGGAAA
TTGACCGCAAGTGGTACTATGACAGCTACACCTGCTGCCCCCCACCCTGGTTCATGATCACAGTCACGCTGCTGGAGGTTGCCTTTTTCC
TCTACAATGGGGTGTCACTAGGTCAATTTGTACTGCAGGTAACTCATCCACGTTACTTGAAGAACTCCCTGGTTTACCACCCACAGCTGC
GAGCACAGGTTTGGCGCTACCTGACATACATCTTCATGCATGCAGGGATAGAACACCTGGGACTCAATGTGGTGCTGCAGCTGCTGGTGG
GGGTGCCCCTGGAGATGGTGCATGGAGCCACCCGAATTGGGCTTGTCTACGTGGCCGGTGTTGTGGCAGCAATGCACGTGGCCCAGCCTG
CTGTGGTACTGGCCAGCAGCCGAGGCATCGCCAGCTTTGTGTGTGAGTATGCATCTCCAGGCAAAGCCACTGAGGTCCGGGTGACAGTGC
TTCGGCAGGCTGACAGCCAGGTGACTGAAGTCTGTGCGGCAACCTACATGATGGGGAATGAGTTGACCTTCCTAGATGATTCCATCTGCA
CGGGCACCTCCAGTGGAAATCAAGTGAACCTCACTATCCAAGGACTGAGGGCCATGGACACGGGACTCTACATCTGCAAGGTGGAGCTCA
TGTACCCACCGCCATACTACCTGGGCATAGGCAACGGAACCCAGATTTATGTAATTGATCCAGAACCGTGCCCAGATTCTGACTTCCTCC
TCTGGATCCTTGCAGCAGTTAGTTCGGGGTTGTTTTTTTATAGCTTTCTCCTCACAGCTGTTTCTTTGAGCAAAATGCTAAAGAAAAGAA
GCCCTCTTACAACAGGGGTCTATGTGAAAATGCCCCCAACAGAGCCAGAATGTGAAAAGCAATTTCAGCCTTATTTTATTCCCATCAATT
GAGAAACCATTATGAAGAAGAGAGTCCATATTTCAATTTCCAAGAGCTGAGGCAATTCTAACTTTTTTGCTATCCAGCTATTTTTATTTG
TTTGTGCATTTGGGGGGAATTCATCTCTCTTTAATATAAAGTTGGATGCGGAACCCAAATTACGTGTACTACAATTTAAAGCAAAGGAGT
AGAAAGACAGAGCTGGGATGTTTCTGTCACATCAGCTCCACTTTCAGTGAAAGCATCACTTGGGATTAATATGGGGATGCAGCATTATGA
TGTGGGTCAAGGAATTAAGTTAGGGAATGGCACAGCCCAAAGAAGGAAAAGGCAGGGAGCGAGGGAGAAGACTATATTGTACACACCTTA
TATTTACGTATGAGACGTTTATAGCCGAAATGATCTTTTCAAGTTAAATTTTATGCCTTTTATTTCTTAAACAAATGTATGATTACATCA
AGGCTTCAAAAATACTCACATGGCTATGTTTTAGCCAGTGATGCTAAAGGTTGTATTGCATATATACATATATATATATATATATATATA
TATATATATATATATATATATATATATATATATTTTAATTTGATAGTATTGTGCATAGAGCCACGTATGTTTTTGTGTATTTGTTAATGG
TTTGAATATAAACACTATATGGCAGTGTCTTTCCACCTTGGGTCCCAGGGAAGTTTTGTGGAGGAGCTCAGGACACTAATACACCAGGTA
GAACACAAGGTCATTTGCTAACTAGCTTGGAAACTGGATGAGGTCATAGCAGTGCTTGATTGCGTGGAATTGTGCTGAGTTGGTGTTGAC
ATGTGCTTTGGGGCTTTTACACCAGTTCCTTTCAATGGTTTGCAAGGAAGCCACAGCTGGTGGTATCTGAGTTGACTTGACAGAACACTG
TCTTGAAGACAATGGCTTACTCCAGGAGACCCACAGGTATGACCTTCTAGGAAGCTCCAGTTCGATGGGCCCAATTCTTACAAACATGTG
GTTAATGCCATGGACAGAAGAAGGCAGCAGGTGGCAGAATGGGGTGCATGAAGGTTTCTGAAAATTAACACTGCTTGTGTTTTTAACTCA

>73892_73892_5_RHBDL3-CTLA4_RHBDL3_chr17_30625223_ENST00000536287_CTLA4_chr2_204735309_ENST00000302823_length(amino acids)=365AA_BP=178
MHGLPLCQHWKVLFDQMSNKRSNSFRQAILQGNRRLSSKALLEEKGLSLSQRLIRHVAYETLPREIDRKWYYDSYTCCPPPWFMITVTLL
EVAFFLYNGVSLGQFVLQVTHPRYLKNSLVYHPQLRAQVWRYLTYIFMHAGIEHLGLNVVLQLLVGVPLEMVHGATRIGLVYVAGVVAAM
HVAQPAVVLASSRGIASFVCEYASPGKATEVRVTVLRQADSQVTEVCAATYMMGNELTFLDDSICTGTSSGNQVNLTIQGLRAMDTGLYI
CKVELMYPPPYYLGIGNGTQIYVIDPEPCPDSDFLLWILAAVSSGLFFYSFLLTAVSLSKMLKKRSPLTTGVYVKMPPTEPECEKQFQPY

--------------------------------------------------------------
>73892_73892_6_RHBDL3-CTLA4_RHBDL3_chr17_30625223_ENST00000536287_CTLA4_chr2_204735309_ENST00000472206_length(transcript)=777nt_BP=609nt
ATGTCAGAAACATCCGAGGACTACAGAGACCTTGGTGATAAGTGTGTCTTTCTTTCTCTCCTCTTCTTCCTCTCCTGCATGGCCTCCCTC
TCTGCCAGCACTGGAAAGTCCTGTTTGATCAGATGAGCAACAAGCGTTCCAACAGCTTCCGCCAAGCCATCCTGCAGGGCAACCGCAGGC
TAAGCAGCAAGGCCCTGCTGGAGGAGAAGGGGCTGAGCCTCTCGCAGCGACTTATCCGCCATGTGGCCTATGAGACCCTGCCCCGGGAAA
TTGACCGCAAGTGGTACTATGACAGCTACACCTGCTGCCCCCCACCCTGGTTCATGATCACAGTCACGCTGCTGGAGGTTGCCTTTTTCC
TCTACAATGGGGTGTCACTAGGTCAATTTGTACTGCAGGTAACTCATCCACGTTACTTGAAGAACTCCCTGGTTTACCACCCACAGCTGC
GAGCACAGGTTTGGCGCTACCTGACATACATCTTCATGCATGCAGGGATAGAACACCTGGGACTCAATGTGGTGCTGCAGCTGCTGGTGG
GGGTGCCCCTGGAGATGGTGCATGGAGCCACCCGAATTGGGCTTGTCTACGTGGCCGGTGTTGTGGCAGCAATGCACGTGGCCCAGCCTG
CTGTGGTACTGGCCAGCAGCCGAGGCATCGCCAGCTTTGTGTCTAAAGAAAAGAAGCCCTCTTACAACAGGGGTCTATGTGAAAATGCCC

>73892_73892_6_RHBDL3-CTLA4_RHBDL3_chr17_30625223_ENST00000536287_CTLA4_chr2_204735309_ENST00000472206_length(amino acids)=221AA_BP=178
MHGLPLCQHWKVLFDQMSNKRSNSFRQAILQGNRRLSSKALLEEKGLSLSQRLIRHVAYETLPREIDRKWYYDSYTCCPPPWFMITVTLL
EVAFFLYNGVSLGQFVLQVTHPRYLKNSLVYHPQLRAQVWRYLTYIFMHAGIEHLGLNVVLQLLVGVPLEMVHGATRIGLVYVAGVVAAM

--------------------------------------------------------------
>73892_73892_7_RHBDL3-CTLA4_RHBDL3_chr17_30625223_ENST00000538145_CTLA4_chr2_204735309_ENST00000295854_length(transcript)=1186nt_BP=770nt
CCCCGTCTCGGCCATGGGCGAGCACCCCAGCCCGGGCCCCGCGGTGGCCGCCTGCGCCGAGGCGGAGCGCATCGAGGAGCTGGAACCCGA
GGCCGAGGAGCGGCTGCCCGCGGCGCCGGAGGACTTTGACCCTGGGAACACAGGCTACATTAGCACAGGCAAGTTCCGGAGTCTTCTGGA
GAGCCACAGCTCCAAGCTGGACCCGCACAAAAGGGAGGTCCTCCTGGCTCTTGCCGACAGCCACGCGGATGGGCAGATCGGCTACCAGGA
TTTTGTCAGCCTAATGAGCAACAAGCGTTCCAACAGCTTCCGCCAAGCCATCCTGCAGGGCAACCGCAGGCTAAGCAGCAAGGCCCTGCT
GGAGGAGAAGGGGCTGAGCCTCTCGCAGCGACTTATCCGCCATGTGGCCTATGAGACCCTGCCCCGGGAAATTGACCGCAAGTGGTACTA
TGACAGCTACACCTGCTGCCCCCCACCCTGGTTCATGATCACAGTCACGCTGCTGGAGGTTGCCTTTTTCCTCTACAATGGGGTGTCACT
AGGTCAATTTGTACTGCAGGTAACTCATCCACGTTACTTGAAGAACTCCCTGGTTTACCACCCACAGCTGCGAGCACAGGTTTGGCGCTA
CCTGACATACATCTTCATGCATGCAGGGATAGAACACCTGGGACTCAATGTGGTGCTGCAGCTGCTGGTGGGGGTGCCCCTGGAGATGGT
GCATGGAGCCACCCGAATTGGGCTTGTCTACGTGGCCGGTGTTGTGGCAGCAATGCACGTGGCCCAGCCTGCTGTGGTACTGGCCAGCAG
CCGAGGCATCGCCAGCTTTGTGTGTGAGTATGCATCTCCAGGCAAAGCCACTGAGGTCCGGGTGACAGTGCTTCGGCAGGCTGACAGCCA
GGTGACTGAAGTCTGTGCGGCAACCTACATGATGGGGAATGAGTTGACCTTCCTAGATGATTCCATCTGCACGGGCACCTCCAGTGGAAA
TCAAGTGAACCTCACTATCCAAGGACTGAGGGCCATGGACACGGGACTCTACATCTGCAAGGTGGAGCTCATGTACCCACCGCCATACTA
CCTGGGCATAGGCAACGGAACCCAGATTTATGTAATTGCTAAAGAAAAGAAGCCCTCTTACAACAGGGGTCTATGTGAAAATGCCCCCAA

>73892_73892_7_RHBDL3-CTLA4_RHBDL3_chr17_30625223_ENST00000538145_CTLA4_chr2_204735309_ENST00000295854_length(amino acids)=391AA_BP=252
MGEHPSPGPAVAACAEAERIEELEPEAEERLPAAPEDFDPGNTGYISTGKFRSLLESHSSKLDPHKREVLLALADSHADGQIGYQDFVSL
MSNKRSNSFRQAILQGNRRLSSKALLEEKGLSLSQRLIRHVAYETLPREIDRKWYYDSYTCCPPPWFMITVTLLEVAFFLYNGVSLGQFV
LQVTHPRYLKNSLVYHPQLRAQVWRYLTYIFMHAGIEHLGLNVVLQLLVGVPLEMVHGATRIGLVYVAGVVAAMHVAQPAVVLASSRGIA
SFVCEYASPGKATEVRVTVLRQADSQVTEVCAATYMMGNELTFLDDSICTGTSSGNQVNLTIQGLRAMDTGLYICKVELMYPPPYYLGIG

--------------------------------------------------------------
>73892_73892_8_RHBDL3-CTLA4_RHBDL3_chr17_30625223_ENST00000538145_CTLA4_chr2_204735309_ENST00000302823_length(transcript)=2481nt_BP=770nt
CCCCGTCTCGGCCATGGGCGAGCACCCCAGCCCGGGCCCCGCGGTGGCCGCCTGCGCCGAGGCGGAGCGCATCGAGGAGCTGGAACCCGA
GGCCGAGGAGCGGCTGCCCGCGGCGCCGGAGGACTTTGACCCTGGGAACACAGGCTACATTAGCACAGGCAAGTTCCGGAGTCTTCTGGA
GAGCCACAGCTCCAAGCTGGACCCGCACAAAAGGGAGGTCCTCCTGGCTCTTGCCGACAGCCACGCGGATGGGCAGATCGGCTACCAGGA
TTTTGTCAGCCTAATGAGCAACAAGCGTTCCAACAGCTTCCGCCAAGCCATCCTGCAGGGCAACCGCAGGCTAAGCAGCAAGGCCCTGCT
GGAGGAGAAGGGGCTGAGCCTCTCGCAGCGACTTATCCGCCATGTGGCCTATGAGACCCTGCCCCGGGAAATTGACCGCAAGTGGTACTA
TGACAGCTACACCTGCTGCCCCCCACCCTGGTTCATGATCACAGTCACGCTGCTGGAGGTTGCCTTTTTCCTCTACAATGGGGTGTCACT
AGGTCAATTTGTACTGCAGGTAACTCATCCACGTTACTTGAAGAACTCCCTGGTTTACCACCCACAGCTGCGAGCACAGGTTTGGCGCTA
CCTGACATACATCTTCATGCATGCAGGGATAGAACACCTGGGACTCAATGTGGTGCTGCAGCTGCTGGTGGGGGTGCCCCTGGAGATGGT
GCATGGAGCCACCCGAATTGGGCTTGTCTACGTGGCCGGTGTTGTGGCAGCAATGCACGTGGCCCAGCCTGCTGTGGTACTGGCCAGCAG
CCGAGGCATCGCCAGCTTTGTGTGTGAGTATGCATCTCCAGGCAAAGCCACTGAGGTCCGGGTGACAGTGCTTCGGCAGGCTGACAGCCA
GGTGACTGAAGTCTGTGCGGCAACCTACATGATGGGGAATGAGTTGACCTTCCTAGATGATTCCATCTGCACGGGCACCTCCAGTGGAAA
TCAAGTGAACCTCACTATCCAAGGACTGAGGGCCATGGACACGGGACTCTACATCTGCAAGGTGGAGCTCATGTACCCACCGCCATACTA
CCTGGGCATAGGCAACGGAACCCAGATTTATGTAATTGATCCAGAACCGTGCCCAGATTCTGACTTCCTCCTCTGGATCCTTGCAGCAGT
TAGTTCGGGGTTGTTTTTTTATAGCTTTCTCCTCACAGCTGTTTCTTTGAGCAAAATGCTAAAGAAAAGAAGCCCTCTTACAACAGGGGT
CTATGTGAAAATGCCCCCAACAGAGCCAGAATGTGAAAAGCAATTTCAGCCTTATTTTATTCCCATCAATTGAGAAACCATTATGAAGAA
GAGAGTCCATATTTCAATTTCCAAGAGCTGAGGCAATTCTAACTTTTTTGCTATCCAGCTATTTTTATTTGTTTGTGCATTTGGGGGGAA
TTCATCTCTCTTTAATATAAAGTTGGATGCGGAACCCAAATTACGTGTACTACAATTTAAAGCAAAGGAGTAGAAAGACAGAGCTGGGAT
GTTTCTGTCACATCAGCTCCACTTTCAGTGAAAGCATCACTTGGGATTAATATGGGGATGCAGCATTATGATGTGGGTCAAGGAATTAAG
TTAGGGAATGGCACAGCCCAAAGAAGGAAAAGGCAGGGAGCGAGGGAGAAGACTATATTGTACACACCTTATATTTACGTATGAGACGTT
TATAGCCGAAATGATCTTTTCAAGTTAAATTTTATGCCTTTTATTTCTTAAACAAATGTATGATTACATCAAGGCTTCAAAAATACTCAC
ATGGCTATGTTTTAGCCAGTGATGCTAAAGGTTGTATTGCATATATACATATATATATATATATATATATATATATATATATATATATAT
ATATATATATATATTTTAATTTGATAGTATTGTGCATAGAGCCACGTATGTTTTTGTGTATTTGTTAATGGTTTGAATATAAACACTATA
TGGCAGTGTCTTTCCACCTTGGGTCCCAGGGAAGTTTTGTGGAGGAGCTCAGGACACTAATACACCAGGTAGAACACAAGGTCATTTGCT
AACTAGCTTGGAAACTGGATGAGGTCATAGCAGTGCTTGATTGCGTGGAATTGTGCTGAGTTGGTGTTGACATGTGCTTTGGGGCTTTTA
CACCAGTTCCTTTCAATGGTTTGCAAGGAAGCCACAGCTGGTGGTATCTGAGTTGACTTGACAGAACACTGTCTTGAAGACAATGGCTTA
CTCCAGGAGACCCACAGGTATGACCTTCTAGGAAGCTCCAGTTCGATGGGCCCAATTCTTACAAACATGTGGTTAATGCCATGGACAGAA
GAAGGCAGCAGGTGGCAGAATGGGGTGCATGAAGGTTTCTGAAAATTAACACTGCTTGTGTTTTTAACTCAATATTTTCCATGAAAATGC

>73892_73892_8_RHBDL3-CTLA4_RHBDL3_chr17_30625223_ENST00000538145_CTLA4_chr2_204735309_ENST00000302823_length(amino acids)=439AA_BP=252
MGEHPSPGPAVAACAEAERIEELEPEAEERLPAAPEDFDPGNTGYISTGKFRSLLESHSSKLDPHKREVLLALADSHADGQIGYQDFVSL
MSNKRSNSFRQAILQGNRRLSSKALLEEKGLSLSQRLIRHVAYETLPREIDRKWYYDSYTCCPPPWFMITVTLLEVAFFLYNGVSLGQFV
LQVTHPRYLKNSLVYHPQLRAQVWRYLTYIFMHAGIEHLGLNVVLQLLVGVPLEMVHGATRIGLVYVAGVVAAMHVAQPAVVLASSRGIA
SFVCEYASPGKATEVRVTVLRQADSQVTEVCAATYMMGNELTFLDDSICTGTSSGNQVNLTIQGLRAMDTGLYICKVELMYPPPYYLGIG

--------------------------------------------------------------
>73892_73892_9_RHBDL3-CTLA4_RHBDL3_chr17_30625223_ENST00000538145_CTLA4_chr2_204735309_ENST00000472206_length(transcript)=938nt_BP=770nt
CCCCGTCTCGGCCATGGGCGAGCACCCCAGCCCGGGCCCCGCGGTGGCCGCCTGCGCCGAGGCGGAGCGCATCGAGGAGCTGGAACCCGA
GGCCGAGGAGCGGCTGCCCGCGGCGCCGGAGGACTTTGACCCTGGGAACACAGGCTACATTAGCACAGGCAAGTTCCGGAGTCTTCTGGA
GAGCCACAGCTCCAAGCTGGACCCGCACAAAAGGGAGGTCCTCCTGGCTCTTGCCGACAGCCACGCGGATGGGCAGATCGGCTACCAGGA
TTTTGTCAGCCTAATGAGCAACAAGCGTTCCAACAGCTTCCGCCAAGCCATCCTGCAGGGCAACCGCAGGCTAAGCAGCAAGGCCCTGCT
GGAGGAGAAGGGGCTGAGCCTCTCGCAGCGACTTATCCGCCATGTGGCCTATGAGACCCTGCCCCGGGAAATTGACCGCAAGTGGTACTA
TGACAGCTACACCTGCTGCCCCCCACCCTGGTTCATGATCACAGTCACGCTGCTGGAGGTTGCCTTTTTCCTCTACAATGGGGTGTCACT
AGGTCAATTTGTACTGCAGGTAACTCATCCACGTTACTTGAAGAACTCCCTGGTTTACCACCCACAGCTGCGAGCACAGGTTTGGCGCTA
CCTGACATACATCTTCATGCATGCAGGGATAGAACACCTGGGACTCAATGTGGTGCTGCAGCTGCTGGTGGGGGTGCCCCTGGAGATGGT
GCATGGAGCCACCCGAATTGGGCTTGTCTACGTGGCCGGTGTTGTGGCAGCAATGCACGTGGCCCAGCCTGCTGTGGTACTGGCCAGCAG
CCGAGGCATCGCCAGCTTTGTGTCTAAAGAAAAGAAGCCCTCTTACAACAGGGGTCTATGTGAAAATGCCCCCAACAGAGCCAGAATGTG

>73892_73892_9_RHBDL3-CTLA4_RHBDL3_chr17_30625223_ENST00000538145_CTLA4_chr2_204735309_ENST00000472206_length(amino acids)=295AA_BP=252
MGEHPSPGPAVAACAEAERIEELEPEAEERLPAAPEDFDPGNTGYISTGKFRSLLESHSSKLDPHKREVLLALADSHADGQIGYQDFVSL
MSNKRSNSFRQAILQGNRRLSSKALLEEKGLSLSQRLIRHVAYETLPREIDRKWYYDSYTCCPPPWFMITVTLLEVAFFLYNGVSLGQFV
LQVTHPRYLKNSLVYHPQLRAQVWRYLTYIFMHAGIEHLGLNVVLQLLVGVPLEMVHGATRIGLVYVAGVVAAMHVAQPAVVLASSRGIA

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for RHBDL3-CTLA4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for RHBDL3-CTLA4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for RHBDL3-CTLA4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource