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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATE1-DNAJB12 (FusionGDB2 ID:7393)

Fusion Gene Summary for ATE1-DNAJB12

check button Fusion gene summary
Fusion gene informationFusion gene name: ATE1-DNAJB12
Fusion gene ID: 7393
HgeneTgene
Gene symbol

ATE1

DNAJB12

Gene ID

11101

54788

Gene namearginyltransferase 1DnaJ heat shock protein family (Hsp40) member B12
Synonyms-DJ10
Cytomap

10q26.13

10q22.1

Type of geneprotein-codingprotein-coding
Descriptionarginyl-tRNA--protein transferase 1R-transferase 1arginine-tRNA--protein transferase 1arginyl-tRNA-protein transferasednaJ homolog subfamily B member 12DnaJ (Hsp40) homolog, subfamily B, member 12
Modification date2020031320200313
UniProtAcc.

Q9NXW2

Ensembl transtripts involved in fusion geneENST00000224652, ENST00000369040, 
ENST00000369043, ENST00000540606, 
ENST00000543447, ENST00000535655, 
ENST00000481784, 		ENST00000461919, 
ENST00000338820, ENST00000394903, 
ENST00000444643, 
Fusion gene scores* DoF score7 X 8 X 7=3927 X 5 X 6=210
# samples 98
** MAII scorelog2(9/392*10)=-2.12285674778553
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/210*10)=-1.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATE1 [Title/Abstract] AND DNAJB12 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATE1(123670421)-DNAJB12(74104885), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDNAJB12

GO:0034622

cellular protein-containing complex assembly

27916661

TgeneDNAJB12

GO:0036503

ERAD pathway

21148293|21150129

TgeneDNAJB12

GO:0051085

chaperone cofactor-dependent protein refolding

27916661

TgeneDNAJB12

GO:0071218

cellular response to misfolded protein

21148293|21150129


check buttonFusion gene breakpoints across ATE1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DNAJB12 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-43-8116-01AATE1chr10

123670421

-DNAJB12chr10

74104885

-


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Fusion Gene ORF analysis for ATE1-DNAJB12

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000224652ENST00000461919ATE1chr10

123670421

-DNAJB12chr10

74104885

-
5CDS-intronENST00000369040ENST00000461919ATE1chr10

123670421

-DNAJB12chr10

74104885

-
5CDS-intronENST00000369043ENST00000461919ATE1chr10

123670421

-DNAJB12chr10

74104885

-
5CDS-intronENST00000540606ENST00000461919ATE1chr10

123670421

-DNAJB12chr10

74104885

-
5CDS-intronENST00000543447ENST00000461919ATE1chr10

123670421

-DNAJB12chr10

74104885

-
5UTR-3CDSENST00000535655ENST00000338820ATE1chr10

123670421

-DNAJB12chr10

74104885

-
5UTR-3CDSENST00000535655ENST00000394903ATE1chr10

123670421

-DNAJB12chr10

74104885

-
5UTR-3CDSENST00000535655ENST00000444643ATE1chr10

123670421

-DNAJB12chr10

74104885

-
5UTR-intronENST00000535655ENST00000461919ATE1chr10

123670421

-DNAJB12chr10

74104885

-
Frame-shiftENST00000224652ENST00000394903ATE1chr10

123670421

-DNAJB12chr10

74104885

-
Frame-shiftENST00000224652ENST00000444643ATE1chr10

123670421

-DNAJB12chr10

74104885

-
Frame-shiftENST00000369040ENST00000394903ATE1chr10

123670421

-DNAJB12chr10

74104885

-
Frame-shiftENST00000369040ENST00000444643ATE1chr10

123670421

-DNAJB12chr10

74104885

-
Frame-shiftENST00000369043ENST00000394903ATE1chr10

123670421

-DNAJB12chr10

74104885

-
Frame-shiftENST00000369043ENST00000444643ATE1chr10

123670421

-DNAJB12chr10

74104885

-
Frame-shiftENST00000540606ENST00000394903ATE1chr10

123670421

-DNAJB12chr10

74104885

-
Frame-shiftENST00000540606ENST00000444643ATE1chr10

123670421

-DNAJB12chr10

74104885

-
Frame-shiftENST00000543447ENST00000338820ATE1chr10

123670421

-DNAJB12chr10

74104885

-
Frame-shiftENST00000543447ENST00000394903ATE1chr10

123670421

-DNAJB12chr10

74104885

-
Frame-shiftENST00000543447ENST00000444643ATE1chr10

123670421

-DNAJB12chr10

74104885

-
In-frameENST00000224652ENST00000338820ATE1chr10

123670421

-DNAJB12chr10

74104885

-
In-frameENST00000369040ENST00000338820ATE1chr10

123670421

-DNAJB12chr10

74104885

-
In-frameENST00000369043ENST00000338820ATE1chr10

123670421

-DNAJB12chr10

74104885

-
In-frameENST00000540606ENST00000338820ATE1chr10

123670421

-DNAJB12chr10

74104885

-
intron-3CDSENST00000481784ENST00000338820ATE1chr10

123670421

-DNAJB12chr10

74104885

-
intron-3CDSENST00000481784ENST00000394903ATE1chr10

123670421

-DNAJB12chr10

74104885

-
intron-3CDSENST00000481784ENST00000444643ATE1chr10

123670421

-DNAJB12chr10

74104885

-
intron-intronENST00000481784ENST00000461919ATE1chr10

123670421

-DNAJB12chr10

74104885

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000369043ATE1chr10123670421-ENST00000338820DNAJB12chr1074104885-4645670631664533
ENST00000224652ATE1chr10123670421-ENST00000338820DNAJB12chr1074104885-4644669621663533
ENST00000369040ATE1chr10123670421-ENST00000338820DNAJB12chr1074104885-45035281371522461
ENST00000540606ATE1chr10123670421-ENST00000338820DNAJB12chr1074104885-4558583211577518

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000369043ENST00000338820ATE1chr10123670421-DNAJB12chr1074104885-0.0035117790.9964882
ENST00000224652ENST00000338820ATE1chr10123670421-DNAJB12chr1074104885-0.0035086010.9964914
ENST00000369040ENST00000338820ATE1chr10123670421-DNAJB12chr1074104885-0.004728250.99527174
ENST00000540606ENST00000338820ATE1chr10123670421-DNAJB12chr1074104885-0.0037636580.9962364

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Fusion Genomic Features for ATE1-DNAJB12


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ATE1-DNAJB12


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:123670421/chr10:74104885)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DNAJB12

Q9NXW2

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway (PubMed:21150129, PubMed:21148293). Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities. Can also act independently of HSPA8/Hsc70: together with DNAJB14, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers (PubMed:27916661). While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70 (PubMed:27916661). When overexpressed, forms membranous structures together with DNAJB14 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear (PubMed:24732912). {ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27916661}.; FUNCTION: (Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection (PubMed:21673190, PubMed:24675744). {ECO:0000269|PubMed:21673190, ECO:0000269|PubMed:24675744}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDNAJB12chr10:123670421chr10:74104885ENST0000044464309112_17644807.6666666666666DomainJ
TgeneDNAJB12chr10:123670421chr10:74104885ENST0000044464309265_37544807.6666666666666Topological domainLumenal
TgeneDNAJB12chr10:123670421chr10:74104885ENST0000044464309244_26444807.6666666666666TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDNAJB12chr10:123670421chr10:74104885ENST00000444643091_24344807.6666666666666Topological domainCytoplasmic


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Fusion Gene Sequence for ATE1-DNAJB12


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>7393_7393_1_ATE1-DNAJB12_ATE1_chr10_123670421_ENST00000224652_DNAJB12_chr10_74104885_ENST00000338820_length(transcript)=4644nt_BP=669nt
GGGCGGCGCGCTGCATTGTGGGGTGGCGGCGGCGGCCGCGCTAGCGACGCGGGGCCGGGCGGCTGAGCGTTCGCGGGGCCGAGGCCATGG
CTTTCTGGGCGGGGGGTTCGCCCAGCGTCGTGGACTATTTCCCTAGCGAGGACTTCTACCGCTGCGGCTACTGCAAGAACGAGTCGGGCA
GCCGCTCCAATGGCATGTGGGCACATTCCATGACAGTACAGGATTATCAGGATCTCATAGACCGAGGATGGCGAAGAAGTGGAAAATATG
TGTACAAACCTGTCATGAATCAAACATGTTGTCCTCAGTACACAATAAGGTGCCGACCTTTACAATTTCAGCCTTCAAAATCTCACAAGA
AGGTTTTGAAAAAAATGTTGAAATTTCTAGCTAAAGGGGAGGTTCCCAAAGGAAGTTGTGAGGATGAGCCCATGGATTCCACAATGGATG
ATGCTGTTGCGGGTGACTTTGCATTGATAAATAAACTGGATATACAGTGTGATCTTAAAACACTCAGTGATGACATCAAAGAGAGTTTAG
AGAGTGAAGGAAAAAATTCAAAGAAAGAAGAACCTCAGGAATTACTTCAGTCACAAGATTTCGTAGGAGAGAAGTTGGGCTCTGGTGAAC
CGTCACATTCAGTTAAAGTTCACACAGTTCCTAAGCCAGCCCTGATTGAGTCCCTCAACCAGAAACCACAGACTGCCGGTGACCAACCCC
CACCCACAGACACAACCCATGCCACCCACAGGAAAGCAGGTGGGACCGATGCCCCCTCGGCCAACGGTGAAGCTGGAGGAGAGAGCACCA
AAGGCTACACTGCAGAACAGGTTGCAGCTGTGAAAAGGGTCAAGCAATGTAAAGATTACTATGAGATCCTGGGGGTGAGCAGAGGGGCCT
CGGATGAGGACCTGAAGAAGGCCTACCGCAGACTGGCCCTCAAATTCCACCCAGACAAGAACCACGCACCTGGTGCCACTGAAGCCTTCA
AAGCCATTGGCACAGCATATGCGGTACTCAGCAACCCGGAGAAGAGGAAGCAGTATGACCAGTTCGGCGATGACAAGAGCCAGGCGGCCC
GGCACGGCCATGGGCATGGGGATTTCCACCGTGGCTTTGAGGCCGACATCTCCCCTGAAGACCTCTTCAACATGTTCTTTGGCGGCGGCT
TCCCTTCTAGTAACGTCCACGTCTACAGCAACGGCCGCATGCGCTATACCTACCAGCAAAGGCAGGACCGCAGGGACAACCAGGGTGATG
GCGGGCTAGGGGTGTTTGTGCAGCTGATGCCTATCCTCATCCTGATTCTCGTGTCAGCTCTCAGCCAGCTCATGGTCTCCAGTCCACCCT
ACAGTCTGAGTCCAAGACCGTCCGTGGGCCACATCCACAGGCGAGTCACTGACCACCTGGGTGTCGTCTACTATGTGGGAGACACTTTCT
CCGAAGAGTACACAGGCTCCAGCCTCAAAACAGTCGAGCGGAATGTGGAAGATGATTATATCGCCAACCTCCGGAACAACTGCTGGAAGG
AGAAGCAGCAGAAGGAAGGCTTGCTGTACCGGGCACGCTACTTTGGCGACACAGATATGTACCACAGAGCACAGAAGATGGGCACCCCCA
GCTGCAGCCGACTGTCAGAGGTGCAGGCCTCCCTGCATGGATAGTCCTGGGCCAGCCACACCACCGAGGTCCAAGTATGAGCCAGGGCTG
CCTCCACCCTGCAACTCCTGGCAGCTTTGGCCCTGGTCATGAGCAGAGGAGGGAGGGGGAGAAAGGGAGGAAGCCTGGTGATTGTGGCAA
AGACTCCTGTCCCCAGCCTGACCTCCAGCCTCCAGAGACCGAGCAGCTGTGGGGCCTGCTGGGAAACCAAGGTCGGTTTCCGCCCTCTAG
CGATGCTGTCCTCCCCACTCCTCCGCTCTGCTCCCTGGCTCCAGGGGTGTGGGGGACCCCAGAACCAGGCAGAGTGGGAACTTGAAACTG
TTGCTGAGGGCCACCCGGGGCTTCTTGGTCCACTCCAGCCATCAGTCAGCACGGCCCTTTCTCCAGCACAGCAGACTATTGTCCGTGCCC
TGGTATTTAGGCCATCACATATGGTGGGGCCCAAGAGAGCCCCATATGCACACTGCCTGCCTGATACCAGGAAGAACCATGTGGGAATAG
GTGGGCCAAGAGCCCTCCCCTTTCTCCATCCCTCCAGCTAGGAGGAAATGGAGCAAGATGAACAGGCAGCCACGAGGTGGGTGGGAGCTG
GCAGTCTTGGTGGCGGCAGGGGCCGCGGGCCCTGACCACCCCCCTCTGGTGGGATCTGAGGCACTCTCTCGAATGCCGTCACACCTGGCA
GCCTGGAAGCCACAGGCATCCGGCCTTGCCCAGGCATCTCGCCTGCGGTCTGAGGAAGGGAACAGAAGGTCATGAGTTCAGGGTCAGACG
CAGCCGCTCAGCACAGGAGGGGTGGAGGGGAAATGAGAGTTGCTGGTAGCAGGCTCCCTCCTTCTGCAGCCCGGCGAATGGGGGCGCTGG
GCTCTGTTCCCAGCGTTTGCCAGAGGTGGCCACTTCAGCCAAGCCCAGAGAAGTGTGGGCAGAAGCAGTGAAGGTTCTTCTCTGTGTGGG
TGCCCTGCCCACCCCCTCCTTTGCCTGTGTCCTCCCGGCCTGGATCCATGGCTGACTCTGCCTGGAGGCCATTTGTGCCTGCCTCTGTGC
TGCCGCAGGAGGGCAGGCCGCAAGTGGGGTTGGTGGGGGTCGAGCGGGCAGCACGGTGCAGCGGTGCAGTGGCAAGGGGGGCTACTTGTG
TGGCATAAGCTAGAGGAGCCGGTGCCGCCTGAATGCCGAGCTAACTGTTGCCACTCTCCTCCCCAGACTATGAAATCCCTGGAGAATTTT
TGGTGACATGCACTGAGCCAAGGTGATGGACTGTATATTTGAGGAAAGACAAACAAAGAAACAAAATTAAAATGGAATTGGAGGCCGAAC
GCTGCACAGCTGCCCTCTCTCTCACCCAGTAAATGCAGAAAGCTCTTAGGACAGACAGAAAACCTGCCATGGGGCTGCTTCCCTCCCTCG
CAGGGCTGGCGGAGGCTCCGCATCGCCTCTCTCCTAGGATACAGAAACCATGGCAACGAAAGTAGAATGTAAAACTCGCAGCAGATATCA
GTGGGAAGGGCTGGGGGAGGGGGCACCCAGCTGCCTTTCCTCCCTCACAGGAGCCACCACCAGCCACCTCTCAGGAGAAGCCAGAGGCCC
TGGCCAAAGATAGGAGGAAGAAAGAGAACTCTCCATAGAATGTAATTTATAGATGCGTGTATATGTATATATATCTATTTATATGTAAAT
AGGCATATATGAAGATATATATATATATAGTCTACTTTTTAAACTCTGCAGGGATTTGGTTAAGTTGTTGAGCTGATTTCTTCCATGTTT
TAGAAAATGAGGCCTGTTTGGGGAAGGTACCCTGGTGATGTTTTTGCTAGACATTAGCTGTAGCTGACAGCATAAGGAGAGTCGCATCAG
AGCTTTTCACAGCCCCCCGAAACCCCAGCCTGGTTTTGATGGCAGCAGTAATCATGATAGTGTGAACCCGCGAAGGCCTCAGGATTATGG
TTAACCTGGAGAGGAGCAGGCCATGGAGGCAGGTGCCAGGTCAGTATTGAGTCACAGTAGAGGCCCCACAAGGACCTGCTTGGGTGAGAC
CACCTCTCCCCTCTCAGCAGCGCTGGTGGGCTCTTTGTCCTGGTGCCCAGGAGCCCTCCAGCCCCCTGCCCACAGAAGGGAAGGCCTGCA
GAGGGGGCCAGGATCTACCTAACCATTTCCCCACCCCTAAGTCCCTCAGTGGGCTTTGCCTTATAGGTGCCACAGGGCACAGCTCCATCA
TTGCCACTGGTTTTTCCTAAGTCATGCACCAAGGACTTCAGAAAGTTCTTCCTCCGAGTCAGTCAGTGGTGCCGGGACCCCAGGGCAGCC
TCCTCGACTCCTGAAGAAAAGGCAGTGCCCGTGGCTGCCTCTGTCTTCACTCGCTGTTGATGTGACCGCCAGGCCTCCTCTCGTACCTTG
GACAAAGGATACACCTGAACCAGAATAGTTTTCTTACCCTCACATTGAAATGAGGATTTTGCTTAAAACAGCACTTGCCGCCAGTGGGAG
GAGGGAGGTTTTATTTATTCCCACAGTTTCTCCTGGGCCTTCTGGAATGACCATGTTTTCCTGTGGCGGTGGGTGTGTCATTGCGCCCGC
CGTCTTCCAAAGCCTTACTTCCCCAAGCTGCCAGCCAGGAGGTGATAACCACCCTCCCAGAGTTTCTCTCGGCTCTTTTTTTAAAAGTCC
CCCAACAAATAGGATTCTTGCTGGGAAAGGAAGTTCGGTAAGGAAATGTCAAATCTGGTTTTTAAACAAGGTCCAACCCTGCAATGAAGC
AGCCACTTCAGCCCAGAGAGATTATAAGAACTGATGTGGCCAGAGTGCCTACCCACTGTGGCCCCGGTGCTCTGCCCCCACGCCCCGACC
ATCTGGTCTTGGTAGATGTCCCTAGACGGGCTGAGCCATGTGCAATAAGAACATAGATCCTAAAGGATCCTCTGGAAGCTGTATTTCTTG

>7393_7393_1_ATE1-DNAJB12_ATE1_chr10_123670421_ENST00000224652_DNAJB12_chr10_74104885_ENST00000338820_length(amino acids)=533AA_BP=202
MSVRGAEAMAFWAGGSPSVVDYFPSEDFYRCGYCKNESGSRSNGMWAHSMTVQDYQDLIDRGWRRSGKYVYKPVMNQTCCPQYTIRCRPL
QFQPSKSHKKVLKKMLKFLAKGEVPKGSCEDEPMDSTMDDAVAGDFALINKLDIQCDLKTLSDDIKESLESEGKNSKKEEPQELLQSQDF
VGEKLGSGEPSHSVKVHTVPKPALIESLNQKPQTAGDQPPPTDTTHATHRKAGGTDAPSANGEAGGESTKGYTAEQVAAVKRVKQCKDYY
EILGVSRGASDEDLKKAYRRLALKFHPDKNHAPGATEAFKAIGTAYAVLSNPEKRKQYDQFGDDKSQAARHGHGHGDFHRGFEADISPED
LFNMFFGGGFPSSNVHVYSNGRMRYTYQQRQDRRDNQGDGGLGVFVQLMPILILILVSALSQLMVSSPPYSLSPRPSVGHIHRRVTDHLG

--------------------------------------------------------------
>7393_7393_2_ATE1-DNAJB12_ATE1_chr10_123670421_ENST00000369040_DNAJB12_chr10_74104885_ENST00000338820_length(transcript)=4503nt_BP=528nt
ATTGTGGGGTGGCGGCGGCGGCCGCGCTAGCGACGCGGGGCCGGGCGGCTGAGCGTTCGCGGGGCCGAGGCCATGGCTTTCTGGGCGGGG
GGTTCGCCCAGCGTCGTGGACTATTTCCCTAGCGAGGACTTCTACCGCTGCGGCTACTGCAAGAACGAGTCGGGCAGCCGCTCCAATGGT
GCCGACCTTTACAATTTCAGCCTTCAAAATCTCACAAGAAGGTTTTGAAAAAAATGTTGAAATTTCTAGCTAAAGGGGAGGTTCCCAAAG
GAAGTTGTGAGGATGAGCCCATGGATTCCACAATGGATGATGCTGTTGCGGGTGACTTTGCATTGATAAATAAACTGGATATACAGTGTG
ATCTTAAAACACTCAGTGATGACATCAAAGAGAGTTTAGAGAGTGAAGGAAAAAATTCAAAGAAAGAAGAACCTCAGGAATTACTTCAGT
CACAAGATTTCGTAGGAGAGAAGTTGGGCTCTGGTGAACCGTCACATTCAGTTAAAGTTCACACAGTTCCTAAGCCAGCCCTGATTGAGT
CCCTCAACCAGAAACCACAGACTGCCGGTGACCAACCCCCACCCACAGACACAACCCATGCCACCCACAGGAAAGCAGGTGGGACCGATG
CCCCCTCGGCCAACGGTGAAGCTGGAGGAGAGAGCACCAAAGGCTACACTGCAGAACAGGTTGCAGCTGTGAAAAGGGTCAAGCAATGTA
AAGATTACTATGAGATCCTGGGGGTGAGCAGAGGGGCCTCGGATGAGGACCTGAAGAAGGCCTACCGCAGACTGGCCCTCAAATTCCACC
CAGACAAGAACCACGCACCTGGTGCCACTGAAGCCTTCAAAGCCATTGGCACAGCATATGCGGTACTCAGCAACCCGGAGAAGAGGAAGC
AGTATGACCAGTTCGGCGATGACAAGAGCCAGGCGGCCCGGCACGGCCATGGGCATGGGGATTTCCACCGTGGCTTTGAGGCCGACATCT
CCCCTGAAGACCTCTTCAACATGTTCTTTGGCGGCGGCTTCCCTTCTAGTAACGTCCACGTCTACAGCAACGGCCGCATGCGCTATACCT
ACCAGCAAAGGCAGGACCGCAGGGACAACCAGGGTGATGGCGGGCTAGGGGTGTTTGTGCAGCTGATGCCTATCCTCATCCTGATTCTCG
TGTCAGCTCTCAGCCAGCTCATGGTCTCCAGTCCACCCTACAGTCTGAGTCCAAGACCGTCCGTGGGCCACATCCACAGGCGAGTCACTG
ACCACCTGGGTGTCGTCTACTATGTGGGAGACACTTTCTCCGAAGAGTACACAGGCTCCAGCCTCAAAACAGTCGAGCGGAATGTGGAAG
ATGATTATATCGCCAACCTCCGGAACAACTGCTGGAAGGAGAAGCAGCAGAAGGAAGGCTTGCTGTACCGGGCACGCTACTTTGGCGACA
CAGATATGTACCACAGAGCACAGAAGATGGGCACCCCCAGCTGCAGCCGACTGTCAGAGGTGCAGGCCTCCCTGCATGGATAGTCCTGGG
CCAGCCACACCACCGAGGTCCAAGTATGAGCCAGGGCTGCCTCCACCCTGCAACTCCTGGCAGCTTTGGCCCTGGTCATGAGCAGAGGAG
GGAGGGGGAGAAAGGGAGGAAGCCTGGTGATTGTGGCAAAGACTCCTGTCCCCAGCCTGACCTCCAGCCTCCAGAGACCGAGCAGCTGTG
GGGCCTGCTGGGAAACCAAGGTCGGTTTCCGCCCTCTAGCGATGCTGTCCTCCCCACTCCTCCGCTCTGCTCCCTGGCTCCAGGGGTGTG
GGGGACCCCAGAACCAGGCAGAGTGGGAACTTGAAACTGTTGCTGAGGGCCACCCGGGGCTTCTTGGTCCACTCCAGCCATCAGTCAGCA
CGGCCCTTTCTCCAGCACAGCAGACTATTGTCCGTGCCCTGGTATTTAGGCCATCACATATGGTGGGGCCCAAGAGAGCCCCATATGCAC
ACTGCCTGCCTGATACCAGGAAGAACCATGTGGGAATAGGTGGGCCAAGAGCCCTCCCCTTTCTCCATCCCTCCAGCTAGGAGGAAATGG
AGCAAGATGAACAGGCAGCCACGAGGTGGGTGGGAGCTGGCAGTCTTGGTGGCGGCAGGGGCCGCGGGCCCTGACCACCCCCCTCTGGTG
GGATCTGAGGCACTCTCTCGAATGCCGTCACACCTGGCAGCCTGGAAGCCACAGGCATCCGGCCTTGCCCAGGCATCTCGCCTGCGGTCT
GAGGAAGGGAACAGAAGGTCATGAGTTCAGGGTCAGACGCAGCCGCTCAGCACAGGAGGGGTGGAGGGGAAATGAGAGTTGCTGGTAGCA
GGCTCCCTCCTTCTGCAGCCCGGCGAATGGGGGCGCTGGGCTCTGTTCCCAGCGTTTGCCAGAGGTGGCCACTTCAGCCAAGCCCAGAGA
AGTGTGGGCAGAAGCAGTGAAGGTTCTTCTCTGTGTGGGTGCCCTGCCCACCCCCTCCTTTGCCTGTGTCCTCCCGGCCTGGATCCATGG
CTGACTCTGCCTGGAGGCCATTTGTGCCTGCCTCTGTGCTGCCGCAGGAGGGCAGGCCGCAAGTGGGGTTGGTGGGGGTCGAGCGGGCAG
CACGGTGCAGCGGTGCAGTGGCAAGGGGGGCTACTTGTGTGGCATAAGCTAGAGGAGCCGGTGCCGCCTGAATGCCGAGCTAACTGTTGC
CACTCTCCTCCCCAGACTATGAAATCCCTGGAGAATTTTTGGTGACATGCACTGAGCCAAGGTGATGGACTGTATATTTGAGGAAAGACA
AACAAAGAAACAAAATTAAAATGGAATTGGAGGCCGAACGCTGCACAGCTGCCCTCTCTCTCACCCAGTAAATGCAGAAAGCTCTTAGGA
CAGACAGAAAACCTGCCATGGGGCTGCTTCCCTCCCTCGCAGGGCTGGCGGAGGCTCCGCATCGCCTCTCTCCTAGGATACAGAAACCAT
GGCAACGAAAGTAGAATGTAAAACTCGCAGCAGATATCAGTGGGAAGGGCTGGGGGAGGGGGCACCCAGCTGCCTTTCCTCCCTCACAGG
AGCCACCACCAGCCACCTCTCAGGAGAAGCCAGAGGCCCTGGCCAAAGATAGGAGGAAGAAAGAGAACTCTCCATAGAATGTAATTTATA
GATGCGTGTATATGTATATATATCTATTTATATGTAAATAGGCATATATGAAGATATATATATATATAGTCTACTTTTTAAACTCTGCAG
GGATTTGGTTAAGTTGTTGAGCTGATTTCTTCCATGTTTTAGAAAATGAGGCCTGTTTGGGGAAGGTACCCTGGTGATGTTTTTGCTAGA
CATTAGCTGTAGCTGACAGCATAAGGAGAGTCGCATCAGAGCTTTTCACAGCCCCCCGAAACCCCAGCCTGGTTTTGATGGCAGCAGTAA
TCATGATAGTGTGAACCCGCGAAGGCCTCAGGATTATGGTTAACCTGGAGAGGAGCAGGCCATGGAGGCAGGTGCCAGGTCAGTATTGAG
TCACAGTAGAGGCCCCACAAGGACCTGCTTGGGTGAGACCACCTCTCCCCTCTCAGCAGCGCTGGTGGGCTCTTTGTCCTGGTGCCCAGG
AGCCCTCCAGCCCCCTGCCCACAGAAGGGAAGGCCTGCAGAGGGGGCCAGGATCTACCTAACCATTTCCCCACCCCTAAGTCCCTCAGTG
GGCTTTGCCTTATAGGTGCCACAGGGCACAGCTCCATCATTGCCACTGGTTTTTCCTAAGTCATGCACCAAGGACTTCAGAAAGTTCTTC
CTCCGAGTCAGTCAGTGGTGCCGGGACCCCAGGGCAGCCTCCTCGACTCCTGAAGAAAAGGCAGTGCCCGTGGCTGCCTCTGTCTTCACT
CGCTGTTGATGTGACCGCCAGGCCTCCTCTCGTACCTTGGACAAAGGATACACCTGAACCAGAATAGTTTTCTTACCCTCACATTGAAAT
GAGGATTTTGCTTAAAACAGCACTTGCCGCCAGTGGGAGGAGGGAGGTTTTATTTATTCCCACAGTTTCTCCTGGGCCTTCTGGAATGAC
CATGTTTTCCTGTGGCGGTGGGTGTGTCATTGCGCCCGCCGTCTTCCAAAGCCTTACTTCCCCAAGCTGCCAGCCAGGAGGTGATAACCA
CCCTCCCAGAGTTTCTCTCGGCTCTTTTTTTAAAAGTCCCCCAACAAATAGGATTCTTGCTGGGAAAGGAAGTTCGGTAAGGAAATGTCA
AATCTGGTTTTTAAACAAGGTCCAACCCTGCAATGAAGCAGCCACTTCAGCCCAGAGAGATTATAAGAACTGATGTGGCCAGAGTGCCTA
CCCACTGTGGCCCCGGTGCTCTGCCCCCACGCCCCGACCATCTGGTCTTGGTAGATGTCCCTAGACGGGCTGAGCCATGTGCAATAAGAA
CATAGATCCTAAAGGATCCTCTGGAAGCTGTATTTCTTGAATTAGAATTCTCAAATTGTACATCTGTTAATATATGTTTATTATGTGACT

>7393_7393_2_ATE1-DNAJB12_ATE1_chr10_123670421_ENST00000369040_DNAJB12_chr10_74104885_ENST00000338820_length(amino acids)=461AA_BP=130
MRLLQERVGQPLQWCRPLQFQPSKSHKKVLKKMLKFLAKGEVPKGSCEDEPMDSTMDDAVAGDFALINKLDIQCDLKTLSDDIKESLESE
GKNSKKEEPQELLQSQDFVGEKLGSGEPSHSVKVHTVPKPALIESLNQKPQTAGDQPPPTDTTHATHRKAGGTDAPSANGEAGGESTKGY
TAEQVAAVKRVKQCKDYYEILGVSRGASDEDLKKAYRRLALKFHPDKNHAPGATEAFKAIGTAYAVLSNPEKRKQYDQFGDDKSQAARHG
HGHGDFHRGFEADISPEDLFNMFFGGGFPSSNVHVYSNGRMRYTYQQRQDRRDNQGDGGLGVFVQLMPILILILVSALSQLMVSSPPYSL
SPRPSVGHIHRRVTDHLGVVYYVGDTFSEEYTGSSLKTVERNVEDDYIANLRNNCWKEKQQKEGLLYRARYFGDTDMYHRAQKMGTPSCS

--------------------------------------------------------------
>7393_7393_3_ATE1-DNAJB12_ATE1_chr10_123670421_ENST00000369043_DNAJB12_chr10_74104885_ENST00000338820_length(transcript)=4645nt_BP=670nt
CGGGCGGCGCGCTGCATTGTGGGGTGGCGGCGGCGGCCGCGCTAGCGACGCGGGGCCGGGCGGCTGAGCGTTCGCGGGGCCGAGGCCATG
GCTTTCTGGGCGGGGGGTTCGCCCAGCGTCGTGGACTATTTCCCTAGCGAGGACTTCTACCGCTGCGGCTACTGCAAGAACGAGTCGGGC
AGCCGCTCCAATGGCATGTGGGCACATTCCATGACAGTACAGGATTATCAGGATCTCATAGACCGAGGATGGCGAAGAAGTGGAAAATAT
GTGTACAAACCTGTCATGAATCAAACATGTTGTCCTCAGTACACAATAAGGTGCCGACCTTTACAATTTCAGCCTTCAAAATCTCACAAG
AAGGTTTTGAAAAAAATGTTGAAATTTCTAGCTAAAGGGGAGGTTCCCAAAGGAAGTTGTGAGGATGAGCCCATGGATTCCACAATGGAT
GATGCTGTTGCGGGTGACTTTGCATTGATAAATAAACTGGATATACAGTGTGATCTTAAAACACTCAGTGATGACATCAAAGAGAGTTTA
GAGAGTGAAGGAAAAAATTCAAAGAAAGAAGAACCTCAGGAATTACTTCAGTCACAAGATTTCGTAGGAGAGAAGTTGGGCTCTGGTGAA
CCGTCACATTCAGTTAAAGTTCACACAGTTCCTAAGCCAGCCCTGATTGAGTCCCTCAACCAGAAACCACAGACTGCCGGTGACCAACCC
CCACCCACAGACACAACCCATGCCACCCACAGGAAAGCAGGTGGGACCGATGCCCCCTCGGCCAACGGTGAAGCTGGAGGAGAGAGCACC
AAAGGCTACACTGCAGAACAGGTTGCAGCTGTGAAAAGGGTCAAGCAATGTAAAGATTACTATGAGATCCTGGGGGTGAGCAGAGGGGCC
TCGGATGAGGACCTGAAGAAGGCCTACCGCAGACTGGCCCTCAAATTCCACCCAGACAAGAACCACGCACCTGGTGCCACTGAAGCCTTC
AAAGCCATTGGCACAGCATATGCGGTACTCAGCAACCCGGAGAAGAGGAAGCAGTATGACCAGTTCGGCGATGACAAGAGCCAGGCGGCC
CGGCACGGCCATGGGCATGGGGATTTCCACCGTGGCTTTGAGGCCGACATCTCCCCTGAAGACCTCTTCAACATGTTCTTTGGCGGCGGC
TTCCCTTCTAGTAACGTCCACGTCTACAGCAACGGCCGCATGCGCTATACCTACCAGCAAAGGCAGGACCGCAGGGACAACCAGGGTGAT
GGCGGGCTAGGGGTGTTTGTGCAGCTGATGCCTATCCTCATCCTGATTCTCGTGTCAGCTCTCAGCCAGCTCATGGTCTCCAGTCCACCC
TACAGTCTGAGTCCAAGACCGTCCGTGGGCCACATCCACAGGCGAGTCACTGACCACCTGGGTGTCGTCTACTATGTGGGAGACACTTTC
TCCGAAGAGTACACAGGCTCCAGCCTCAAAACAGTCGAGCGGAATGTGGAAGATGATTATATCGCCAACCTCCGGAACAACTGCTGGAAG
GAGAAGCAGCAGAAGGAAGGCTTGCTGTACCGGGCACGCTACTTTGGCGACACAGATATGTACCACAGAGCACAGAAGATGGGCACCCCC
AGCTGCAGCCGACTGTCAGAGGTGCAGGCCTCCCTGCATGGATAGTCCTGGGCCAGCCACACCACCGAGGTCCAAGTATGAGCCAGGGCT
GCCTCCACCCTGCAACTCCTGGCAGCTTTGGCCCTGGTCATGAGCAGAGGAGGGAGGGGGAGAAAGGGAGGAAGCCTGGTGATTGTGGCA
AAGACTCCTGTCCCCAGCCTGACCTCCAGCCTCCAGAGACCGAGCAGCTGTGGGGCCTGCTGGGAAACCAAGGTCGGTTTCCGCCCTCTA
GCGATGCTGTCCTCCCCACTCCTCCGCTCTGCTCCCTGGCTCCAGGGGTGTGGGGGACCCCAGAACCAGGCAGAGTGGGAACTTGAAACT
GTTGCTGAGGGCCACCCGGGGCTTCTTGGTCCACTCCAGCCATCAGTCAGCACGGCCCTTTCTCCAGCACAGCAGACTATTGTCCGTGCC
CTGGTATTTAGGCCATCACATATGGTGGGGCCCAAGAGAGCCCCATATGCACACTGCCTGCCTGATACCAGGAAGAACCATGTGGGAATA
GGTGGGCCAAGAGCCCTCCCCTTTCTCCATCCCTCCAGCTAGGAGGAAATGGAGCAAGATGAACAGGCAGCCACGAGGTGGGTGGGAGCT
GGCAGTCTTGGTGGCGGCAGGGGCCGCGGGCCCTGACCACCCCCCTCTGGTGGGATCTGAGGCACTCTCTCGAATGCCGTCACACCTGGC
AGCCTGGAAGCCACAGGCATCCGGCCTTGCCCAGGCATCTCGCCTGCGGTCTGAGGAAGGGAACAGAAGGTCATGAGTTCAGGGTCAGAC
GCAGCCGCTCAGCACAGGAGGGGTGGAGGGGAAATGAGAGTTGCTGGTAGCAGGCTCCCTCCTTCTGCAGCCCGGCGAATGGGGGCGCTG
GGCTCTGTTCCCAGCGTTTGCCAGAGGTGGCCACTTCAGCCAAGCCCAGAGAAGTGTGGGCAGAAGCAGTGAAGGTTCTTCTCTGTGTGG
GTGCCCTGCCCACCCCCTCCTTTGCCTGTGTCCTCCCGGCCTGGATCCATGGCTGACTCTGCCTGGAGGCCATTTGTGCCTGCCTCTGTG
CTGCCGCAGGAGGGCAGGCCGCAAGTGGGGTTGGTGGGGGTCGAGCGGGCAGCACGGTGCAGCGGTGCAGTGGCAAGGGGGGCTACTTGT
GTGGCATAAGCTAGAGGAGCCGGTGCCGCCTGAATGCCGAGCTAACTGTTGCCACTCTCCTCCCCAGACTATGAAATCCCTGGAGAATTT
TTGGTGACATGCACTGAGCCAAGGTGATGGACTGTATATTTGAGGAAAGACAAACAAAGAAACAAAATTAAAATGGAATTGGAGGCCGAA
CGCTGCACAGCTGCCCTCTCTCTCACCCAGTAAATGCAGAAAGCTCTTAGGACAGACAGAAAACCTGCCATGGGGCTGCTTCCCTCCCTC
GCAGGGCTGGCGGAGGCTCCGCATCGCCTCTCTCCTAGGATACAGAAACCATGGCAACGAAAGTAGAATGTAAAACTCGCAGCAGATATC
AGTGGGAAGGGCTGGGGGAGGGGGCACCCAGCTGCCTTTCCTCCCTCACAGGAGCCACCACCAGCCACCTCTCAGGAGAAGCCAGAGGCC
CTGGCCAAAGATAGGAGGAAGAAAGAGAACTCTCCATAGAATGTAATTTATAGATGCGTGTATATGTATATATATCTATTTATATGTAAA
TAGGCATATATGAAGATATATATATATATAGTCTACTTTTTAAACTCTGCAGGGATTTGGTTAAGTTGTTGAGCTGATTTCTTCCATGTT
TTAGAAAATGAGGCCTGTTTGGGGAAGGTACCCTGGTGATGTTTTTGCTAGACATTAGCTGTAGCTGACAGCATAAGGAGAGTCGCATCA
GAGCTTTTCACAGCCCCCCGAAACCCCAGCCTGGTTTTGATGGCAGCAGTAATCATGATAGTGTGAACCCGCGAAGGCCTCAGGATTATG
GTTAACCTGGAGAGGAGCAGGCCATGGAGGCAGGTGCCAGGTCAGTATTGAGTCACAGTAGAGGCCCCACAAGGACCTGCTTGGGTGAGA
CCACCTCTCCCCTCTCAGCAGCGCTGGTGGGCTCTTTGTCCTGGTGCCCAGGAGCCCTCCAGCCCCCTGCCCACAGAAGGGAAGGCCTGC
AGAGGGGGCCAGGATCTACCTAACCATTTCCCCACCCCTAAGTCCCTCAGTGGGCTTTGCCTTATAGGTGCCACAGGGCACAGCTCCATC
ATTGCCACTGGTTTTTCCTAAGTCATGCACCAAGGACTTCAGAAAGTTCTTCCTCCGAGTCAGTCAGTGGTGCCGGGACCCCAGGGCAGC
CTCCTCGACTCCTGAAGAAAAGGCAGTGCCCGTGGCTGCCTCTGTCTTCACTCGCTGTTGATGTGACCGCCAGGCCTCCTCTCGTACCTT
GGACAAAGGATACACCTGAACCAGAATAGTTTTCTTACCCTCACATTGAAATGAGGATTTTGCTTAAAACAGCACTTGCCGCCAGTGGGA
GGAGGGAGGTTTTATTTATTCCCACAGTTTCTCCTGGGCCTTCTGGAATGACCATGTTTTCCTGTGGCGGTGGGTGTGTCATTGCGCCCG
CCGTCTTCCAAAGCCTTACTTCCCCAAGCTGCCAGCCAGGAGGTGATAACCACCCTCCCAGAGTTTCTCTCGGCTCTTTTTTTAAAAGTC
CCCCAACAAATAGGATTCTTGCTGGGAAAGGAAGTTCGGTAAGGAAATGTCAAATCTGGTTTTTAAACAAGGTCCAACCCTGCAATGAAG
CAGCCACTTCAGCCCAGAGAGATTATAAGAACTGATGTGGCCAGAGTGCCTACCCACTGTGGCCCCGGTGCTCTGCCCCCACGCCCCGAC
CATCTGGTCTTGGTAGATGTCCCTAGACGGGCTGAGCCATGTGCAATAAGAACATAGATCCTAAAGGATCCTCTGGAAGCTGTATTTCTT

>7393_7393_3_ATE1-DNAJB12_ATE1_chr10_123670421_ENST00000369043_DNAJB12_chr10_74104885_ENST00000338820_length(amino acids)=533AA_BP=202
MSVRGAEAMAFWAGGSPSVVDYFPSEDFYRCGYCKNESGSRSNGMWAHSMTVQDYQDLIDRGWRRSGKYVYKPVMNQTCCPQYTIRCRPL
QFQPSKSHKKVLKKMLKFLAKGEVPKGSCEDEPMDSTMDDAVAGDFALINKLDIQCDLKTLSDDIKESLESEGKNSKKEEPQELLQSQDF
VGEKLGSGEPSHSVKVHTVPKPALIESLNQKPQTAGDQPPPTDTTHATHRKAGGTDAPSANGEAGGESTKGYTAEQVAAVKRVKQCKDYY
EILGVSRGASDEDLKKAYRRLALKFHPDKNHAPGATEAFKAIGTAYAVLSNPEKRKQYDQFGDDKSQAARHGHGHGDFHRGFEADISPED
LFNMFFGGGFPSSNVHVYSNGRMRYTYQQRQDRRDNQGDGGLGVFVQLMPILILILVSALSQLMVSSPPYSLSPRPSVGHIHRRVTDHLG

--------------------------------------------------------------
>7393_7393_4_ATE1-DNAJB12_ATE1_chr10_123670421_ENST00000540606_DNAJB12_chr10_74104885_ENST00000338820_length(transcript)=4558nt_BP=583nt
GAGCGGACCCTCGCGGCGGCCATGGCGTCGGTGGTGGAATACAAGGGCCTCAGGGCCGGCTACCACTGCGGCTACTGCGATTCCAAGGAG
GGCAAAGCGTCCTGCGGCATGTGGGCACATTCCATGACAGTACAGGATTATCAGGATCTCATAGACCGAGGATGGCGAAGAAGTGGAAAA
TATGTGTACAAACCTGTCATGAATCAAACATGTTGTCCTCAGTACACAATAAGGTGCCGACCTTTACAATTTCAGCCTTCAAAATCTCAC
AAGAAGGTTTTGAAAAAAATGTTGAAATTTCTAGCTAAAGGGGAGGTTCCCAAAGGAAGTTGTGAGGATGAGCCCATGGATTCCACAATG
GATGATGCTGTTGCGGGTGACTTTGCATTGATAAATAAACTGGATATACAGTGTGATCTTAAAACACTCAGTGATGACATCAAAGAGAGT
TTAGAGAGTGAAGGAAAAAATTCAAAGAAAGAAGAACCTCAGGAATTACTTCAGTCACAAGATTTCGTAGGAGAGAAGTTGGGCTCTGGT
GAACCGTCACATTCAGTTAAAGTTCACACAGTTCCTAAGCCAGCCCTGATTGAGTCCCTCAACCAGAAACCACAGACTGCCGGTGACCAA
CCCCCACCCACAGACACAACCCATGCCACCCACAGGAAAGCAGGTGGGACCGATGCCCCCTCGGCCAACGGTGAAGCTGGAGGAGAGAGC
ACCAAAGGCTACACTGCAGAACAGGTTGCAGCTGTGAAAAGGGTCAAGCAATGTAAAGATTACTATGAGATCCTGGGGGTGAGCAGAGGG
GCCTCGGATGAGGACCTGAAGAAGGCCTACCGCAGACTGGCCCTCAAATTCCACCCAGACAAGAACCACGCACCTGGTGCCACTGAAGCC
TTCAAAGCCATTGGCACAGCATATGCGGTACTCAGCAACCCGGAGAAGAGGAAGCAGTATGACCAGTTCGGCGATGACAAGAGCCAGGCG
GCCCGGCACGGCCATGGGCATGGGGATTTCCACCGTGGCTTTGAGGCCGACATCTCCCCTGAAGACCTCTTCAACATGTTCTTTGGCGGC
GGCTTCCCTTCTAGTAACGTCCACGTCTACAGCAACGGCCGCATGCGCTATACCTACCAGCAAAGGCAGGACCGCAGGGACAACCAGGGT
GATGGCGGGCTAGGGGTGTTTGTGCAGCTGATGCCTATCCTCATCCTGATTCTCGTGTCAGCTCTCAGCCAGCTCATGGTCTCCAGTCCA
CCCTACAGTCTGAGTCCAAGACCGTCCGTGGGCCACATCCACAGGCGAGTCACTGACCACCTGGGTGTCGTCTACTATGTGGGAGACACT
TTCTCCGAAGAGTACACAGGCTCCAGCCTCAAAACAGTCGAGCGGAATGTGGAAGATGATTATATCGCCAACCTCCGGAACAACTGCTGG
AAGGAGAAGCAGCAGAAGGAAGGCTTGCTGTACCGGGCACGCTACTTTGGCGACACAGATATGTACCACAGAGCACAGAAGATGGGCACC
CCCAGCTGCAGCCGACTGTCAGAGGTGCAGGCCTCCCTGCATGGATAGTCCTGGGCCAGCCACACCACCGAGGTCCAAGTATGAGCCAGG
GCTGCCTCCACCCTGCAACTCCTGGCAGCTTTGGCCCTGGTCATGAGCAGAGGAGGGAGGGGGAGAAAGGGAGGAAGCCTGGTGATTGTG
GCAAAGACTCCTGTCCCCAGCCTGACCTCCAGCCTCCAGAGACCGAGCAGCTGTGGGGCCTGCTGGGAAACCAAGGTCGGTTTCCGCCCT
CTAGCGATGCTGTCCTCCCCACTCCTCCGCTCTGCTCCCTGGCTCCAGGGGTGTGGGGGACCCCAGAACCAGGCAGAGTGGGAACTTGAA
ACTGTTGCTGAGGGCCACCCGGGGCTTCTTGGTCCACTCCAGCCATCAGTCAGCACGGCCCTTTCTCCAGCACAGCAGACTATTGTCCGT
GCCCTGGTATTTAGGCCATCACATATGGTGGGGCCCAAGAGAGCCCCATATGCACACTGCCTGCCTGATACCAGGAAGAACCATGTGGGA
ATAGGTGGGCCAAGAGCCCTCCCCTTTCTCCATCCCTCCAGCTAGGAGGAAATGGAGCAAGATGAACAGGCAGCCACGAGGTGGGTGGGA
GCTGGCAGTCTTGGTGGCGGCAGGGGCCGCGGGCCCTGACCACCCCCCTCTGGTGGGATCTGAGGCACTCTCTCGAATGCCGTCACACCT
GGCAGCCTGGAAGCCACAGGCATCCGGCCTTGCCCAGGCATCTCGCCTGCGGTCTGAGGAAGGGAACAGAAGGTCATGAGTTCAGGGTCA
GACGCAGCCGCTCAGCACAGGAGGGGTGGAGGGGAAATGAGAGTTGCTGGTAGCAGGCTCCCTCCTTCTGCAGCCCGGCGAATGGGGGCG
CTGGGCTCTGTTCCCAGCGTTTGCCAGAGGTGGCCACTTCAGCCAAGCCCAGAGAAGTGTGGGCAGAAGCAGTGAAGGTTCTTCTCTGTG
TGGGTGCCCTGCCCACCCCCTCCTTTGCCTGTGTCCTCCCGGCCTGGATCCATGGCTGACTCTGCCTGGAGGCCATTTGTGCCTGCCTCT
GTGCTGCCGCAGGAGGGCAGGCCGCAAGTGGGGTTGGTGGGGGTCGAGCGGGCAGCACGGTGCAGCGGTGCAGTGGCAAGGGGGGCTACT
TGTGTGGCATAAGCTAGAGGAGCCGGTGCCGCCTGAATGCCGAGCTAACTGTTGCCACTCTCCTCCCCAGACTATGAAATCCCTGGAGAA
TTTTTGGTGACATGCACTGAGCCAAGGTGATGGACTGTATATTTGAGGAAAGACAAACAAAGAAACAAAATTAAAATGGAATTGGAGGCC
GAACGCTGCACAGCTGCCCTCTCTCTCACCCAGTAAATGCAGAAAGCTCTTAGGACAGACAGAAAACCTGCCATGGGGCTGCTTCCCTCC
CTCGCAGGGCTGGCGGAGGCTCCGCATCGCCTCTCTCCTAGGATACAGAAACCATGGCAACGAAAGTAGAATGTAAAACTCGCAGCAGAT
ATCAGTGGGAAGGGCTGGGGGAGGGGGCACCCAGCTGCCTTTCCTCCCTCACAGGAGCCACCACCAGCCACCTCTCAGGAGAAGCCAGAG
GCCCTGGCCAAAGATAGGAGGAAGAAAGAGAACTCTCCATAGAATGTAATTTATAGATGCGTGTATATGTATATATATCTATTTATATGT
AAATAGGCATATATGAAGATATATATATATATAGTCTACTTTTTAAACTCTGCAGGGATTTGGTTAAGTTGTTGAGCTGATTTCTTCCAT
GTTTTAGAAAATGAGGCCTGTTTGGGGAAGGTACCCTGGTGATGTTTTTGCTAGACATTAGCTGTAGCTGACAGCATAAGGAGAGTCGCA
TCAGAGCTTTTCACAGCCCCCCGAAACCCCAGCCTGGTTTTGATGGCAGCAGTAATCATGATAGTGTGAACCCGCGAAGGCCTCAGGATT
ATGGTTAACCTGGAGAGGAGCAGGCCATGGAGGCAGGTGCCAGGTCAGTATTGAGTCACAGTAGAGGCCCCACAAGGACCTGCTTGGGTG
AGACCACCTCTCCCCTCTCAGCAGCGCTGGTGGGCTCTTTGTCCTGGTGCCCAGGAGCCCTCCAGCCCCCTGCCCACAGAAGGGAAGGCC
TGCAGAGGGGGCCAGGATCTACCTAACCATTTCCCCACCCCTAAGTCCCTCAGTGGGCTTTGCCTTATAGGTGCCACAGGGCACAGCTCC
ATCATTGCCACTGGTTTTTCCTAAGTCATGCACCAAGGACTTCAGAAAGTTCTTCCTCCGAGTCAGTCAGTGGTGCCGGGACCCCAGGGC
AGCCTCCTCGACTCCTGAAGAAAAGGCAGTGCCCGTGGCTGCCTCTGTCTTCACTCGCTGTTGATGTGACCGCCAGGCCTCCTCTCGTAC
CTTGGACAAAGGATACACCTGAACCAGAATAGTTTTCTTACCCTCACATTGAAATGAGGATTTTGCTTAAAACAGCACTTGCCGCCAGTG
GGAGGAGGGAGGTTTTATTTATTCCCACAGTTTCTCCTGGGCCTTCTGGAATGACCATGTTTTCCTGTGGCGGTGGGTGTGTCATTGCGC
CCGCCGTCTTCCAAAGCCTTACTTCCCCAAGCTGCCAGCCAGGAGGTGATAACCACCCTCCCAGAGTTTCTCTCGGCTCTTTTTTTAAAA
GTCCCCCAACAAATAGGATTCTTGCTGGGAAAGGAAGTTCGGTAAGGAAATGTCAAATCTGGTTTTTAAACAAGGTCCAACCCTGCAATG
AAGCAGCCACTTCAGCCCAGAGAGATTATAAGAACTGATGTGGCCAGAGTGCCTACCCACTGTGGCCCCGGTGCTCTGCCCCCACGCCCC
GACCATCTGGTCTTGGTAGATGTCCCTAGACGGGCTGAGCCATGTGCAATAAGAACATAGATCCTAAAGGATCCTCTGGAAGCTGTATTT

>7393_7393_4_ATE1-DNAJB12_ATE1_chr10_123670421_ENST00000540606_DNAJB12_chr10_74104885_ENST00000338820_length(amino acids)=518AA_BP=187
MASVVEYKGLRAGYHCGYCDSKEGKASCGMWAHSMTVQDYQDLIDRGWRRSGKYVYKPVMNQTCCPQYTIRCRPLQFQPSKSHKKVLKKM
LKFLAKGEVPKGSCEDEPMDSTMDDAVAGDFALINKLDIQCDLKTLSDDIKESLESEGKNSKKEEPQELLQSQDFVGEKLGSGEPSHSVK
VHTVPKPALIESLNQKPQTAGDQPPPTDTTHATHRKAGGTDAPSANGEAGGESTKGYTAEQVAAVKRVKQCKDYYEILGVSRGASDEDLK
KAYRRLALKFHPDKNHAPGATEAFKAIGTAYAVLSNPEKRKQYDQFGDDKSQAARHGHGHGDFHRGFEADISPEDLFNMFFGGGFPSSNV
HVYSNGRMRYTYQQRQDRRDNQGDGGLGVFVQLMPILILILVSALSQLMVSSPPYSLSPRPSVGHIHRRVTDHLGVVYYVGDTFSEEYTG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ATE1-DNAJB12


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATE1-DNAJB12


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATE1-DNAJB12


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource