Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:RHOA-QRICH1 (FusionGDB2 ID:73936)

Fusion Gene Summary for RHOA-QRICH1

Fusion gene summary

Fusion gene information	Fusion gene name: RHOA-QRICH1
	Fusion gene ID: 73936
		Hgene	Tgene
	Gene symbol	RHOA	QRICH1
	Gene ID	387	54870
	Gene name	ras homolog family member A	glutamine rich 1
	Synonyms	ARH12\|ARHA\|EDFAOB\|RHO12\|RHOH12	AB-DIP\|VERBRAS
	Cytomap	3p21.31	3p21.31
	Type of gene	protein-coding	protein-coding
	Description	transforming protein RhoAAplysia ras-related homolog 12epididymis secretory sperm binding proteinoncogene RHO H12small GTP binding protein RhoA	glutamine-rich protein 1
	Modification date	20200329	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000418115, ENST00000422781, ENST00000454011, ENST00000265538,	ENST00000479449, ENST00000357496, ENST00000395443, ENST00000424300,
Fusion gene scores	* DoF score	24 X 14 X 11=3696	13 X 10 X 7=910
	# samples	24	14
	** MAII score	log2(24/3696*10)=-3.94485844580754 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(14/910*10)=-2.70043971814109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: RHOA [Title/Abstract] AND QRICH1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	RHOA(49412866)-QRICH1(49084679), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RHOA	GO:0007266	Rho protein signal transduction	26529257
Hgene	RHOA	GO:0016477	cell migration	26529257
Hgene	RHOA	GO:0032956	regulation of actin cytoskeleton organization	25911094
Hgene	RHOA	GO:0035385	Roundabout signaling pathway	26529257
Hgene	RHOA	GO:0036089	cleavage furrow formation	16103226
Hgene	RHOA	GO:0051496	positive regulation of stress fiber assembly	15467718
Hgene	RHOA	GO:0060193	positive regulation of lipase activity	19887681
Hgene	RHOA	GO:0071222	cellular response to lipopolysaccharide	19734146
Hgene	RHOA	GO:0071902	positive regulation of protein serine/threonine kinase activity	8617235

Fusion gene breakpoints across RHOA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across QRICH1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	TCGA-EJ-7314-11A	RHOA	chr3	49412866	-	QRICH1	chr3	49084679	-

Top

Fusion Gene ORF analysis for RHOA-QRICH1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000418115	ENST00000479449	RHOA	chr3	49412866	-	QRICH1	chr3	49084679	-
5CDS-5UTR	ENST00000422781	ENST00000479449	RHOA	chr3	49412866	-	QRICH1	chr3	49084679	-
5CDS-5UTR	ENST00000454011	ENST00000479449	RHOA	chr3	49412866	-	QRICH1	chr3	49084679	-
In-frame	ENST00000418115	ENST00000357496	RHOA	chr3	49412866	-	QRICH1	chr3	49084679	-
In-frame	ENST00000418115	ENST00000395443	RHOA	chr3	49412866	-	QRICH1	chr3	49084679	-
In-frame	ENST00000418115	ENST00000424300	RHOA	chr3	49412866	-	QRICH1	chr3	49084679	-
In-frame	ENST00000422781	ENST00000357496	RHOA	chr3	49412866	-	QRICH1	chr3	49084679	-
In-frame	ENST00000422781	ENST00000395443	RHOA	chr3	49412866	-	QRICH1	chr3	49084679	-
In-frame	ENST00000422781	ENST00000424300	RHOA	chr3	49412866	-	QRICH1	chr3	49084679	-
In-frame	ENST00000454011	ENST00000357496	RHOA	chr3	49412866	-	QRICH1	chr3	49084679	-
In-frame	ENST00000454011	ENST00000395443	RHOA	chr3	49412866	-	QRICH1	chr3	49084679	-
In-frame	ENST00000454011	ENST00000424300	RHOA	chr3	49412866	-	QRICH1	chr3	49084679	-
intron-3CDS	ENST00000265538	ENST00000357496	RHOA	chr3	49412866	-	QRICH1	chr3	49084679	-
intron-3CDS	ENST00000265538	ENST00000395443	RHOA	chr3	49412866	-	QRICH1	chr3	49084679	-
intron-3CDS	ENST00000265538	ENST00000424300	RHOA	chr3	49412866	-	QRICH1	chr3	49084679	-
intron-5UTR	ENST00000265538	ENST00000479449	RHOA	chr3	49412866	-	QRICH1	chr3	49084679	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000418115	RHOA	chr3	49412866	-	ENST00000395443	QRICH1	chr3	49084679	-	2279	541	385	1533	382
ENST00000418115	RHOA	chr3	49412866	-	ENST00000357496	QRICH1	chr3	49084679	-	2054	541	385	1533	382
ENST00000418115	RHOA	chr3	49412866	-	ENST00000424300	QRICH1	chr3	49084679	-	1774	541	385	1533	382
ENST00000454011	RHOA	chr3	49412866	-	ENST00000395443	QRICH1	chr3	49084679	-	2005	267	111	1259	382
ENST00000454011	RHOA	chr3	49412866	-	ENST00000357496	QRICH1	chr3	49084679	-	1780	267	111	1259	382
ENST00000454011	RHOA	chr3	49412866	-	ENST00000424300	QRICH1	chr3	49084679	-	1500	267	111	1259	382
ENST00000422781	RHOA	chr3	49412866	-	ENST00000395443	QRICH1	chr3	49084679	-	2047	309	153	1301	382
ENST00000422781	RHOA	chr3	49412866	-	ENST00000357496	QRICH1	chr3	49084679	-	1822	309	153	1301	382
ENST00000422781	RHOA	chr3	49412866	-	ENST00000424300	QRICH1	chr3	49084679	-	1542	309	153	1301	382

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000418115	ENST00000395443	RHOA	chr3	49412866	-	QRICH1	chr3	49084679	-	0.000556587	0.99944335
ENST00000418115	ENST00000357496	RHOA	chr3	49412866	-	QRICH1	chr3	49084679	-	0.001042557	0.9989574
ENST00000418115	ENST00000424300	RHOA	chr3	49412866	-	QRICH1	chr3	49084679	-	0.001504082	0.99849594
ENST00000454011	ENST00000395443	RHOA	chr3	49412866	-	QRICH1	chr3	49084679	-	0.000459919	0.9995401
ENST00000454011	ENST00000357496	RHOA	chr3	49412866	-	QRICH1	chr3	49084679	-	0.000876632	0.9991234
ENST00000454011	ENST00000424300	RHOA	chr3	49412866	-	QRICH1	chr3	49084679	-	0.001163472	0.9988366
ENST00000422781	ENST00000395443	RHOA	chr3	49412866	-	QRICH1	chr3	49084679	-	0.000433147	0.99956685
ENST00000422781	ENST00000357496	RHOA	chr3	49412866	-	QRICH1	chr3	49084679	-	0.000824987	0.999175
ENST00000422781	ENST00000424300	RHOA	chr3	49412866	-	QRICH1	chr3	49084679	-	0.001124995	0.99887496

Top

Fusion Genomic Features for RHOA-QRICH1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for RHOA-QRICH1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:49412866/chr3:49084679)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RHOA

chr3:49412866

chr3:49084679

ENST00000418115

34_42

194.0

Motif

Effector region

Hgene

RHOA

chr3:49412866

chr3:49084679

ENST00000418115

12_19

194.0

Nucleotide binding

GTP

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RHOA

chr3:49412866

chr3:49084679

ENST00000418115

182_187

194.0

Compositional bias

Note=Arg/Lys-rich (basic)

Hgene

RHOA

chr3:49412866

chr3:49084679

ENST00000418115

117_120

194.0

Nucleotide binding

GTP

Hgene

RHOA

chr3:49412866

chr3:49084679

ENST00000418115

59_63

194.0

Nucleotide binding

GTP

Tgene

QRICH1

chr3:49412866

chr3:49084679

ENST00000357496

85_462

446

777.0

Compositional bias

Note=Gln-rich

Tgene

QRICH1

chr3:49412866

chr3:49084679

ENST00000395443

85_462

446

777.0

Compositional bias

Note=Gln-rich

Tgene

QRICH1

chr3:49412866

chr3:49084679

ENST00000424300

85_462

446

777.0

Compositional bias

Note=Gln-rich

Tgene

QRICH1

chr3:49412866

chr3:49084679

ENST00000357496

1_64

446

777.0

Domain

Note=CARD

Tgene

QRICH1

chr3:49412866

chr3:49084679

ENST00000395443

1_64

446

777.0

Domain

Note=CARD

Tgene

QRICH1

chr3:49412866

chr3:49084679

ENST00000424300

1_64

446

777.0

Domain

Note=CARD

Top

Fusion Gene Sequence for RHOA-QRICH1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>73936_73936_1_RHOA-QRICH1_RHOA_chr3_49412866_ENST00000418115_QRICH1_chr3_49084679_ENST00000357496_length(transcript)=2054nt_BP=541nt
AATAGCAACCAGGTCTTTTATAGCCCCGGAGTTCCCGTGATGCCCCACGCGGCTGCAATGATTGGTTAAGGGTTTTGCTTTTAGGGCGTG
GACGGGCTCCTGAGCAATAGTGGATGAGCTGTGAGTGCGCGCGCGTGCGCGGGGCCGCGACCTGTGCCGGCTCGAGCCCGCTGGGCACTC
GGAGGCGCGCACGTCGTTCCCCGCCCTCCCGCCGCCGCCCGCCCTCGCTCTCTCGCGCTACCCTCCCGCCGCCCGCGGTCCTCCGTCGGT
TCTCTCGTTAGTCCACGGTCTGGTCTTCAGCTACCCGCCTTCGTCTCCGAGTTTGCGACTCGCGGACCGGCGTCCCCGGCGCGAAGAGGC
TGGACTCGGATTCGTTGCCTGAGCAATGGCTGCCATCCGGAAGAAACTGGTGATTGTTGGTGATGGAGCCTGTGGAAAGACATGCTTGCT
CATAGTCTTCAGCAAGGACCAGTTCCCAGAGGTGTATGTGCCCACAGTGTTTGAGAACTATGTGGCAGATATCGAGGTGGATGGAAAGCA
GGCTCAAACTGTCCAGGTTGCTGAAGTTGAACCACAGTCACAGCCACAGCCTTCCCCAGAACTTCTGCTTCCAAATTCTTTGAAGCCAGA
AGAAGGGCTTGAAGTATGGAAAAACTGGGCCCAGACCAAGAATGCTGAACTAGAGAAGGATGCTCAGAACAGATTGGCACCCATTGGGAG
GCGCCAACTGCTGCGATTCCAGGAAGATCTCATCTCCTCTGCTGTGGCAGAGTTGAATTATGGGCTCTGTCTAATGACACGGGAAGCTCG
AAATGGAGAAGGTGAACCCTATGACCCAGATGTGCTCTACTATATTTTCCTGTGTATTCAAAAGTATCTTTTTGAAAATGGAAGGGTAGA
TGACATTTTCTCCGATCTTTATTATGTTCGGTTCACGGAGTGGCTACATGAAGTTCTGAAGGATGTTCAGCCCCGGGTCACTCCACTTGG
CTATGTCTTGCCCAGCCACGTGACTGAGGAGATGCTATGGGAGTGCAAGCAGCTTGGGGCTCACTCCCCCTCCACCTTGCTGACCACCCT
CATGTTCTTTAATACCAAGTACTTCCTATTGAAGACAGTGGACCAGCACATGAAGCTGGCCTTCTCCAAGGTCTTGCGACAGACAAAGAA
GAACCCCTCTAATCCCAAGGATAAAAGCACGAGTATCCGGTACTTGAAGGCCCTTGGAATACACCAGACTGGCCAGAAAGTTACAGATGA
CATGTATGCAGAACAGACGGAAAATCCAGAGAATCCATTGAGATGTCCCATCAAGCTCTATGATTTCTACCTCTTCAAATGCCCCCAGAG
TGTGAAAGGCCGGAATGACACCTTTTACCTGACACCTGAGCCAGTGGTGGCCCCCAACAGCCCAATCTGGTACTCAGTCCAGCCTATCAG
CAGAGAGCAGATGGGACAAATGCTGACGCGGATCCTGGTGATAAGAGAAATTCAGGAGGCCATCGCAGTGGCCAATGCAAGCACTATGCA
CTGAGATGCCTTGGCCATGGCACAAGAGAAACCAGCCAGGAAAAACCAGACAGACTTTCACACTAAAGAAGAGGCCTCCATTTTTTTTTT
TCTTTTTTTTATTGGTGTAGTTACGAAGCCTTTCAGGCTGCTTCTGTTTAAAATATAAAAGAAAACTTTGCCCCCTTTGCATCTTCATAA
ACCTGCTGCGGCAGACTCCTCAGCCGATGGTGGCTCTGGGTTTCCTTGAGTGTCATATGTCCTAGAAAGTTGCTGGCTGACTCTTTTTTG
TCTGGGGCCTGGGGAAAGGGCTTGGACTGTGAAAAGAAATGTGGCCCCTTTCCATCTTCAAGAGAGATGGAATTAATGATGGATGGACCC
TGGAGGGAATCTCCCCAGCCGACTTCCACTGGGCTGACAGACTTTGCTGACCACAGGGGAACGATGTTCTTTTCTTTCTTCATGATCAGA

>73936_73936_1_RHOA-QRICH1_RHOA_chr3_49412866_ENST00000418115_QRICH1_chr3_49084679_ENST00000357496_length(amino acids)=382AA_BP=0
MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQAQTVQVAEVEPQSQPQPSPELLLPNSLKPEEGLEVWKN
WAQTKNAELEKDAQNRLAPIGRRQLLRFQEDLISSAVAELNYGLCLMTREARNGEGEPYDPDVLYYIFLCIQKYLFENGRVDDIFSDLYY
VRFTEWLHEVLKDVQPRVTPLGYVLPSHVTEEMLWECKQLGAHSPSTLLTTLMFFNTKYFLLKTVDQHMKLAFSKVLRQTKKNPSNPKDK
STSIRYLKALGIHQTGQKVTDDMYAEQTENPENPLRCPIKLYDFYLFKCPQSVKGRNDTFYLTPEPVVAPNSPIWYSVQPISREQMGQML

--------------------------------------------------------------
>73936_73936_2_RHOA-QRICH1_RHOA_chr3_49412866_ENST00000418115_QRICH1_chr3_49084679_ENST00000395443_length(transcript)=2279nt_BP=541nt
AATAGCAACCAGGTCTTTTATAGCCCCGGAGTTCCCGTGATGCCCCACGCGGCTGCAATGATTGGTTAAGGGTTTTGCTTTTAGGGCGTG
GACGGGCTCCTGAGCAATAGTGGATGAGCTGTGAGTGCGCGCGCGTGCGCGGGGCCGCGACCTGTGCCGGCTCGAGCCCGCTGGGCACTC
GGAGGCGCGCACGTCGTTCCCCGCCCTCCCGCCGCCGCCCGCCCTCGCTCTCTCGCGCTACCCTCCCGCCGCCCGCGGTCCTCCGTCGGT
TCTCTCGTTAGTCCACGGTCTGGTCTTCAGCTACCCGCCTTCGTCTCCGAGTTTGCGACTCGCGGACCGGCGTCCCCGGCGCGAAGAGGC
TGGACTCGGATTCGTTGCCTGAGCAATGGCTGCCATCCGGAAGAAACTGGTGATTGTTGGTGATGGAGCCTGTGGAAAGACATGCTTGCT
CATAGTCTTCAGCAAGGACCAGTTCCCAGAGGTGTATGTGCCCACAGTGTTTGAGAACTATGTGGCAGATATCGAGGTGGATGGAAAGCA
GGCTCAAACTGTCCAGGTTGCTGAAGTTGAACCACAGTCACAGCCACAGCCTTCCCCAGAACTTCTGCTTCCAAATTCTTTGAAGCCAGA
AGAAGGGCTTGAAGTATGGAAAAACTGGGCCCAGACCAAGAATGCTGAACTAGAGAAGGATGCTCAGAACAGATTGGCACCCATTGGGAG
GCGCCAACTGCTGCGATTCCAGGAAGATCTCATCTCCTCTGCTGTGGCAGAGTTGAATTATGGGCTCTGTCTAATGACACGGGAAGCTCG
AAATGGAGAAGGTGAACCCTATGACCCAGATGTGCTCTACTATATTTTCCTGTGTATTCAAAAGTATCTTTTTGAAAATGGAAGGGTAGA
TGACATTTTCTCCGATCTTTATTATGTTCGGTTCACGGAGTGGCTACATGAAGTTCTGAAGGATGTTCAGCCCCGGGTCACTCCACTTGG
CTATGTCTTGCCCAGCCACGTGACTGAGGAGATGCTATGGGAGTGCAAGCAGCTTGGGGCTCACTCCCCCTCCACCTTGCTGACCACCCT
CATGTTCTTTAATACCAAGTACTTCCTATTGAAGACAGTGGACCAGCACATGAAGCTGGCCTTCTCCAAGGTCTTGCGACAGACAAAGAA
GAACCCCTCTAATCCCAAGGATAAAAGCACGAGTATCCGGTACTTGAAGGCCCTTGGAATACACCAGACTGGCCAGAAAGTTACAGATGA
CATGTATGCAGAACAGACGGAAAATCCAGAGAATCCATTGAGATGTCCCATCAAGCTCTATGATTTCTACCTCTTCAAATGCCCCCAGAG
TGTGAAAGGCCGGAATGACACCTTTTACCTGACACCTGAGCCAGTGGTGGCCCCCAACAGCCCAATCTGGTACTCAGTCCAGCCTATCAG
CAGAGAGCAGATGGGACAAATGCTGACGCGGATCCTGGTGATAAGAGAAATTCAGGAGGCCATCGCAGTGGCCAATGCAAGCACTATGCA
CTGAGATGCCTTGGCCATGGCACAAGAGAAACCAGCCAGGAAAAACCAGACAGACTTTCACACTAAAGAAGAGGCCTCCATTTTTTTTTT
TCTTTTTTTTATTGGTGTAGTTACGAAGCCTTTCAGGCTGCTTCTGTTTAAAATATAAAAGAAAACTTTGCCCCCTTTGCATCTTCATAA
ACCTGCTGCGGCAGACTCCTCAGCCGATGGTGGCTCTGGGTTTCCTTGAGTGTCATATGTCCTAGAAAGTTGCTGGCTGACTCTTTTTTG
TCTGGGGCCTGGGGAAAGGGCTTGGACTGTGAAAAGAAATGTGGCCCCTTTCCATCTTCAAGAGAGATGGAATTAATGATGGATGGACCC
TGGAGGGAATCTCCCCAGCCGACTTCCACTGGGCTGACAGACTTTGCTGACCACAGGGGAACGATGTTCTTTTCTTTCTTCATGATCAGA
CATAAACTTAGCATCTTAATGGAAGAAAAATGAGGGGAACTTCAATTATGATTTATTAAAGACAATTTCTATTACACCCTCCTTTATGAC
AAGTGACATTTTAGATGTAAAAGTAAAAACTTTACCATGCCTTTTTTTTTTTTGTTGGCCTAACATTGAGGCCTTAAAACCTGAGGCTCC
TGTGCCTGATGGAATTCTTGTAACATACACTTGTGTATCATATAAAGATACCACTCTGTTTCTCTTATGTATTCTTACTCTAGTTGTTTA

>73936_73936_2_RHOA-QRICH1_RHOA_chr3_49412866_ENST00000418115_QRICH1_chr3_49084679_ENST00000395443_length(amino acids)=382AA_BP=0
MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQAQTVQVAEVEPQSQPQPSPELLLPNSLKPEEGLEVWKN
WAQTKNAELEKDAQNRLAPIGRRQLLRFQEDLISSAVAELNYGLCLMTREARNGEGEPYDPDVLYYIFLCIQKYLFENGRVDDIFSDLYY
VRFTEWLHEVLKDVQPRVTPLGYVLPSHVTEEMLWECKQLGAHSPSTLLTTLMFFNTKYFLLKTVDQHMKLAFSKVLRQTKKNPSNPKDK
STSIRYLKALGIHQTGQKVTDDMYAEQTENPENPLRCPIKLYDFYLFKCPQSVKGRNDTFYLTPEPVVAPNSPIWYSVQPISREQMGQML

--------------------------------------------------------------
>73936_73936_3_RHOA-QRICH1_RHOA_chr3_49412866_ENST00000418115_QRICH1_chr3_49084679_ENST00000424300_length(transcript)=1774nt_BP=541nt
AATAGCAACCAGGTCTTTTATAGCCCCGGAGTTCCCGTGATGCCCCACGCGGCTGCAATGATTGGTTAAGGGTTTTGCTTTTAGGGCGTG
GACGGGCTCCTGAGCAATAGTGGATGAGCTGTGAGTGCGCGCGCGTGCGCGGGGCCGCGACCTGTGCCGGCTCGAGCCCGCTGGGCACTC
GGAGGCGCGCACGTCGTTCCCCGCCCTCCCGCCGCCGCCCGCCCTCGCTCTCTCGCGCTACCCTCCCGCCGCCCGCGGTCCTCCGTCGGT
TCTCTCGTTAGTCCACGGTCTGGTCTTCAGCTACCCGCCTTCGTCTCCGAGTTTGCGACTCGCGGACCGGCGTCCCCGGCGCGAAGAGGC
TGGACTCGGATTCGTTGCCTGAGCAATGGCTGCCATCCGGAAGAAACTGGTGATTGTTGGTGATGGAGCCTGTGGAAAGACATGCTTGCT
CATAGTCTTCAGCAAGGACCAGTTCCCAGAGGTGTATGTGCCCACAGTGTTTGAGAACTATGTGGCAGATATCGAGGTGGATGGAAAGCA
GGCTCAAACTGTCCAGGTTGCTGAAGTTGAACCACAGTCACAGCCACAGCCTTCCCCAGAACTTCTGCTTCCAAATTCTTTGAAGCCAGA
AGAAGGGCTTGAAGTATGGAAAAACTGGGCCCAGACCAAGAATGCTGAACTAGAGAAGGATGCTCAGAACAGATTGGCACCCATTGGGAG
GCGCCAACTGCTGCGATTCCAGGAAGATCTCATCTCCTCTGCTGTGGCAGAGTTGAATTATGGGCTCTGTCTAATGACACGGGAAGCTCG
AAATGGAGAAGGTGAACCCTATGACCCAGATGTGCTCTACTATATTTTCCTGTGTATTCAAAAGTATCTTTTTGAAAATGGAAGGGTAGA
TGACATTTTCTCCGATCTTTATTATGTTCGGTTCACGGAGTGGCTACATGAAGTTCTGAAGGATGTTCAGCCCCGGGTCACTCCACTTGG
CTATGTCTTGCCCAGCCACGTGACTGAGGAGATGCTATGGGAGTGCAAGCAGCTTGGGGCTCACTCCCCCTCCACCTTGCTGACCACCCT
CATGTTCTTTAATACCAAGTACTTCCTATTGAAGACAGTGGACCAGCACATGAAGCTGGCCTTCTCCAAGGTCTTGCGACAGACAAAGAA
GAACCCCTCTAATCCCAAGGATAAAAGCACGAGTATCCGGTACTTGAAGGCCCTTGGAATACACCAGACTGGCCAGAAAGTTACAGATGA
CATGTATGCAGAACAGACGGAAAATCCAGAGAATCCATTGAGATGTCCCATCAAGCTCTATGATTTCTACCTCTTCAAATGCCCCCAGAG
TGTGAAAGGCCGGAATGACACCTTTTACCTGACACCTGAGCCAGTGGTGGCCCCCAACAGCCCAATCTGGTACTCAGTCCAGCCTATCAG
CAGAGAGCAGATGGGACAAATGCTGACGCGGATCCTGGTGATAAGAGAAATTCAGGAGGCCATCGCAGTGGCCAATGCAAGCACTATGCA
CTGAGATGCCTTGGCCATGGCACAAGAGAAACCAGCCAGGAAAAACCAGACAGACTTTCACACTAAAGAAGAGGCCTCCATTTTTTTTTT
TCTTTTTTTTATTGGTGTAGTTACGAAGCCTTTCAGGCTGCTTCTGTTTAAAATATAAAAGAAAACTTTGCCCCCTTTGCATCTTCATAA

>73936_73936_3_RHOA-QRICH1_RHOA_chr3_49412866_ENST00000418115_QRICH1_chr3_49084679_ENST00000424300_length(amino acids)=382AA_BP=0
MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQAQTVQVAEVEPQSQPQPSPELLLPNSLKPEEGLEVWKN
WAQTKNAELEKDAQNRLAPIGRRQLLRFQEDLISSAVAELNYGLCLMTREARNGEGEPYDPDVLYYIFLCIQKYLFENGRVDDIFSDLYY
VRFTEWLHEVLKDVQPRVTPLGYVLPSHVTEEMLWECKQLGAHSPSTLLTTLMFFNTKYFLLKTVDQHMKLAFSKVLRQTKKNPSNPKDK
STSIRYLKALGIHQTGQKVTDDMYAEQTENPENPLRCPIKLYDFYLFKCPQSVKGRNDTFYLTPEPVVAPNSPIWYSVQPISREQMGQML

--------------------------------------------------------------
>73936_73936_4_RHOA-QRICH1_RHOA_chr3_49412866_ENST00000422781_QRICH1_chr3_49084679_ENST00000357496_length(transcript)=1822nt_BP=309nt
TCGCGCTACCCTCCCGCCGCCCGCGGTCCTCCGTCGGTTCTCTCGTTAGTCCACGGTCTGGTCTTCAGCTACCCGCCTTCGTCTCCGAGT
TTGCGACTCGCGGACCGGCGTCCCCGGCGCGAAGAGGCTGGACTCGGATTCGTTGCCTGAGCAATGGCTGCCATCCGGAAGAAACTGGTG
ATTGTTGGTGATGGAGCCTGTGGAAAGACATGCTTGCTCATAGTCTTCAGCAAGGACCAGTTCCCAGAGGTGTATGTGCCCACAGTGTTT
GAGAACTATGTGGCAGATATCGAGGTGGATGGAAAGCAGGCTCAAACTGTCCAGGTTGCTGAAGTTGAACCACAGTCACAGCCACAGCCT
TCCCCAGAACTTCTGCTTCCAAATTCTTTGAAGCCAGAAGAAGGGCTTGAAGTATGGAAAAACTGGGCCCAGACCAAGAATGCTGAACTA
GAGAAGGATGCTCAGAACAGATTGGCACCCATTGGGAGGCGCCAACTGCTGCGATTCCAGGAAGATCTCATCTCCTCTGCTGTGGCAGAG
TTGAATTATGGGCTCTGTCTAATGACACGGGAAGCTCGAAATGGAGAAGGTGAACCCTATGACCCAGATGTGCTCTACTATATTTTCCTG
TGTATTCAAAAGTATCTTTTTGAAAATGGAAGGGTAGATGACATTTTCTCCGATCTTTATTATGTTCGGTTCACGGAGTGGCTACATGAA
GTTCTGAAGGATGTTCAGCCCCGGGTCACTCCACTTGGCTATGTCTTGCCCAGCCACGTGACTGAGGAGATGCTATGGGAGTGCAAGCAG
CTTGGGGCTCACTCCCCCTCCACCTTGCTGACCACCCTCATGTTCTTTAATACCAAGTACTTCCTATTGAAGACAGTGGACCAGCACATG
AAGCTGGCCTTCTCCAAGGTCTTGCGACAGACAAAGAAGAACCCCTCTAATCCCAAGGATAAAAGCACGAGTATCCGGTACTTGAAGGCC
CTTGGAATACACCAGACTGGCCAGAAAGTTACAGATGACATGTATGCAGAACAGACGGAAAATCCAGAGAATCCATTGAGATGTCCCATC
AAGCTCTATGATTTCTACCTCTTCAAATGCCCCCAGAGTGTGAAAGGCCGGAATGACACCTTTTACCTGACACCTGAGCCAGTGGTGGCC
CCCAACAGCCCAATCTGGTACTCAGTCCAGCCTATCAGCAGAGAGCAGATGGGACAAATGCTGACGCGGATCCTGGTGATAAGAGAAATT
CAGGAGGCCATCGCAGTGGCCAATGCAAGCACTATGCACTGAGATGCCTTGGCCATGGCACAAGAGAAACCAGCCAGGAAAAACCAGACA
GACTTTCACACTAAAGAAGAGGCCTCCATTTTTTTTTTTCTTTTTTTTATTGGTGTAGTTACGAAGCCTTTCAGGCTGCTTCTGTTTAAA
ATATAAAAGAAAACTTTGCCCCCTTTGCATCTTCATAAACCTGCTGCGGCAGACTCCTCAGCCGATGGTGGCTCTGGGTTTCCTTGAGTG
TCATATGTCCTAGAAAGTTGCTGGCTGACTCTTTTTTGTCTGGGGCCTGGGGAAAGGGCTTGGACTGTGAAAAGAAATGTGGCCCCTTTC
CATCTTCAAGAGAGATGGAATTAATGATGGATGGACCCTGGAGGGAATCTCCCCAGCCGACTTCCACTGGGCTGACAGACTTTGCTGACC
ACAGGGGAACGATGTTCTTTTCTTTCTTCATGATCAGACATAAACTTAGCATCTTAATGGAAGAAAAATGAGGGGAACTTCAATTATGAT

>73936_73936_4_RHOA-QRICH1_RHOA_chr3_49412866_ENST00000422781_QRICH1_chr3_49084679_ENST00000357496_length(amino acids)=382AA_BP=0
MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQAQTVQVAEVEPQSQPQPSPELLLPNSLKPEEGLEVWKN
WAQTKNAELEKDAQNRLAPIGRRQLLRFQEDLISSAVAELNYGLCLMTREARNGEGEPYDPDVLYYIFLCIQKYLFENGRVDDIFSDLYY
VRFTEWLHEVLKDVQPRVTPLGYVLPSHVTEEMLWECKQLGAHSPSTLLTTLMFFNTKYFLLKTVDQHMKLAFSKVLRQTKKNPSNPKDK
STSIRYLKALGIHQTGQKVTDDMYAEQTENPENPLRCPIKLYDFYLFKCPQSVKGRNDTFYLTPEPVVAPNSPIWYSVQPISREQMGQML

--------------------------------------------------------------
>73936_73936_5_RHOA-QRICH1_RHOA_chr3_49412866_ENST00000422781_QRICH1_chr3_49084679_ENST00000395443_length(transcript)=2047nt_BP=309nt
TCGCGCTACCCTCCCGCCGCCCGCGGTCCTCCGTCGGTTCTCTCGTTAGTCCACGGTCTGGTCTTCAGCTACCCGCCTTCGTCTCCGAGT
TTGCGACTCGCGGACCGGCGTCCCCGGCGCGAAGAGGCTGGACTCGGATTCGTTGCCTGAGCAATGGCTGCCATCCGGAAGAAACTGGTG
ATTGTTGGTGATGGAGCCTGTGGAAAGACATGCTTGCTCATAGTCTTCAGCAAGGACCAGTTCCCAGAGGTGTATGTGCCCACAGTGTTT
GAGAACTATGTGGCAGATATCGAGGTGGATGGAAAGCAGGCTCAAACTGTCCAGGTTGCTGAAGTTGAACCACAGTCACAGCCACAGCCT
TCCCCAGAACTTCTGCTTCCAAATTCTTTGAAGCCAGAAGAAGGGCTTGAAGTATGGAAAAACTGGGCCCAGACCAAGAATGCTGAACTA
GAGAAGGATGCTCAGAACAGATTGGCACCCATTGGGAGGCGCCAACTGCTGCGATTCCAGGAAGATCTCATCTCCTCTGCTGTGGCAGAG
TTGAATTATGGGCTCTGTCTAATGACACGGGAAGCTCGAAATGGAGAAGGTGAACCCTATGACCCAGATGTGCTCTACTATATTTTCCTG
TGTATTCAAAAGTATCTTTTTGAAAATGGAAGGGTAGATGACATTTTCTCCGATCTTTATTATGTTCGGTTCACGGAGTGGCTACATGAA
GTTCTGAAGGATGTTCAGCCCCGGGTCACTCCACTTGGCTATGTCTTGCCCAGCCACGTGACTGAGGAGATGCTATGGGAGTGCAAGCAG
CTTGGGGCTCACTCCCCCTCCACCTTGCTGACCACCCTCATGTTCTTTAATACCAAGTACTTCCTATTGAAGACAGTGGACCAGCACATG
AAGCTGGCCTTCTCCAAGGTCTTGCGACAGACAAAGAAGAACCCCTCTAATCCCAAGGATAAAAGCACGAGTATCCGGTACTTGAAGGCC
CTTGGAATACACCAGACTGGCCAGAAAGTTACAGATGACATGTATGCAGAACAGACGGAAAATCCAGAGAATCCATTGAGATGTCCCATC
AAGCTCTATGATTTCTACCTCTTCAAATGCCCCCAGAGTGTGAAAGGCCGGAATGACACCTTTTACCTGACACCTGAGCCAGTGGTGGCC
CCCAACAGCCCAATCTGGTACTCAGTCCAGCCTATCAGCAGAGAGCAGATGGGACAAATGCTGACGCGGATCCTGGTGATAAGAGAAATT
CAGGAGGCCATCGCAGTGGCCAATGCAAGCACTATGCACTGAGATGCCTTGGCCATGGCACAAGAGAAACCAGCCAGGAAAAACCAGACA
GACTTTCACACTAAAGAAGAGGCCTCCATTTTTTTTTTTCTTTTTTTTATTGGTGTAGTTACGAAGCCTTTCAGGCTGCTTCTGTTTAAA
ATATAAAAGAAAACTTTGCCCCCTTTGCATCTTCATAAACCTGCTGCGGCAGACTCCTCAGCCGATGGTGGCTCTGGGTTTCCTTGAGTG
TCATATGTCCTAGAAAGTTGCTGGCTGACTCTTTTTTGTCTGGGGCCTGGGGAAAGGGCTTGGACTGTGAAAAGAAATGTGGCCCCTTTC
CATCTTCAAGAGAGATGGAATTAATGATGGATGGACCCTGGAGGGAATCTCCCCAGCCGACTTCCACTGGGCTGACAGACTTTGCTGACC
ACAGGGGAACGATGTTCTTTTCTTTCTTCATGATCAGACATAAACTTAGCATCTTAATGGAAGAAAAATGAGGGGAACTTCAATTATGAT
TTATTAAAGACAATTTCTATTACACCCTCCTTTATGACAAGTGACATTTTAGATGTAAAAGTAAAAACTTTACCATGCCTTTTTTTTTTT
TGTTGGCCTAACATTGAGGCCTTAAAACCTGAGGCTCCTGTGCCTGATGGAATTCTTGTAACATACACTTGTGTATCATATAAAGATACC

>73936_73936_5_RHOA-QRICH1_RHOA_chr3_49412866_ENST00000422781_QRICH1_chr3_49084679_ENST00000395443_length(amino acids)=382AA_BP=0
MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQAQTVQVAEVEPQSQPQPSPELLLPNSLKPEEGLEVWKN
WAQTKNAELEKDAQNRLAPIGRRQLLRFQEDLISSAVAELNYGLCLMTREARNGEGEPYDPDVLYYIFLCIQKYLFENGRVDDIFSDLYY
VRFTEWLHEVLKDVQPRVTPLGYVLPSHVTEEMLWECKQLGAHSPSTLLTTLMFFNTKYFLLKTVDQHMKLAFSKVLRQTKKNPSNPKDK
STSIRYLKALGIHQTGQKVTDDMYAEQTENPENPLRCPIKLYDFYLFKCPQSVKGRNDTFYLTPEPVVAPNSPIWYSVQPISREQMGQML

--------------------------------------------------------------
>73936_73936_6_RHOA-QRICH1_RHOA_chr3_49412866_ENST00000422781_QRICH1_chr3_49084679_ENST00000424300_length(transcript)=1542nt_BP=309nt
TCGCGCTACCCTCCCGCCGCCCGCGGTCCTCCGTCGGTTCTCTCGTTAGTCCACGGTCTGGTCTTCAGCTACCCGCCTTCGTCTCCGAGT
TTGCGACTCGCGGACCGGCGTCCCCGGCGCGAAGAGGCTGGACTCGGATTCGTTGCCTGAGCAATGGCTGCCATCCGGAAGAAACTGGTG
ATTGTTGGTGATGGAGCCTGTGGAAAGACATGCTTGCTCATAGTCTTCAGCAAGGACCAGTTCCCAGAGGTGTATGTGCCCACAGTGTTT
GAGAACTATGTGGCAGATATCGAGGTGGATGGAAAGCAGGCTCAAACTGTCCAGGTTGCTGAAGTTGAACCACAGTCACAGCCACAGCCT
TCCCCAGAACTTCTGCTTCCAAATTCTTTGAAGCCAGAAGAAGGGCTTGAAGTATGGAAAAACTGGGCCCAGACCAAGAATGCTGAACTA
GAGAAGGATGCTCAGAACAGATTGGCACCCATTGGGAGGCGCCAACTGCTGCGATTCCAGGAAGATCTCATCTCCTCTGCTGTGGCAGAG
TTGAATTATGGGCTCTGTCTAATGACACGGGAAGCTCGAAATGGAGAAGGTGAACCCTATGACCCAGATGTGCTCTACTATATTTTCCTG
TGTATTCAAAAGTATCTTTTTGAAAATGGAAGGGTAGATGACATTTTCTCCGATCTTTATTATGTTCGGTTCACGGAGTGGCTACATGAA
GTTCTGAAGGATGTTCAGCCCCGGGTCACTCCACTTGGCTATGTCTTGCCCAGCCACGTGACTGAGGAGATGCTATGGGAGTGCAAGCAG
CTTGGGGCTCACTCCCCCTCCACCTTGCTGACCACCCTCATGTTCTTTAATACCAAGTACTTCCTATTGAAGACAGTGGACCAGCACATG
AAGCTGGCCTTCTCCAAGGTCTTGCGACAGACAAAGAAGAACCCCTCTAATCCCAAGGATAAAAGCACGAGTATCCGGTACTTGAAGGCC
CTTGGAATACACCAGACTGGCCAGAAAGTTACAGATGACATGTATGCAGAACAGACGGAAAATCCAGAGAATCCATTGAGATGTCCCATC
AAGCTCTATGATTTCTACCTCTTCAAATGCCCCCAGAGTGTGAAAGGCCGGAATGACACCTTTTACCTGACACCTGAGCCAGTGGTGGCC
CCCAACAGCCCAATCTGGTACTCAGTCCAGCCTATCAGCAGAGAGCAGATGGGACAAATGCTGACGCGGATCCTGGTGATAAGAGAAATT
CAGGAGGCCATCGCAGTGGCCAATGCAAGCACTATGCACTGAGATGCCTTGGCCATGGCACAAGAGAAACCAGCCAGGAAAAACCAGACA
GACTTTCACACTAAAGAAGAGGCCTCCATTTTTTTTTTTCTTTTTTTTATTGGTGTAGTTACGAAGCCTTTCAGGCTGCTTCTGTTTAAA
ATATAAAAGAAAACTTTGCCCCCTTTGCATCTTCATAAACCTGCTGCGGCAGACTCCTCAGCCGATGGTGGCTCTGGGTTTCCTTGAGTG

>73936_73936_6_RHOA-QRICH1_RHOA_chr3_49412866_ENST00000422781_QRICH1_chr3_49084679_ENST00000424300_length(amino acids)=382AA_BP=0
MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQAQTVQVAEVEPQSQPQPSPELLLPNSLKPEEGLEVWKN
WAQTKNAELEKDAQNRLAPIGRRQLLRFQEDLISSAVAELNYGLCLMTREARNGEGEPYDPDVLYYIFLCIQKYLFENGRVDDIFSDLYY
VRFTEWLHEVLKDVQPRVTPLGYVLPSHVTEEMLWECKQLGAHSPSTLLTTLMFFNTKYFLLKTVDQHMKLAFSKVLRQTKKNPSNPKDK
STSIRYLKALGIHQTGQKVTDDMYAEQTENPENPLRCPIKLYDFYLFKCPQSVKGRNDTFYLTPEPVVAPNSPIWYSVQPISREQMGQML

--------------------------------------------------------------
>73936_73936_7_RHOA-QRICH1_RHOA_chr3_49412866_ENST00000454011_QRICH1_chr3_49084679_ENST00000357496_length(transcript)=1780nt_BP=267nt
TCGTTAGTCCACGGTCTGGTCTTCAGCTACCCGCCTTCGTCTCCGAGTTTGCGACTCGCGGACCGGCGTCCCCGGCGCGAAGAGGCTGGA
CTCGGATTCGTTGCCTGAGCAATGGCTGCCATCCGGAAGAAACTGGTGATTGTTGGTGATGGAGCCTGTGGAAAGACATGCTTGCTCATA
GTCTTCAGCAAGGACCAGTTCCCAGAGGTGTATGTGCCCACAGTGTTTGAGAACTATGTGGCAGATATCGAGGTGGATGGAAAGCAGGCT
CAAACTGTCCAGGTTGCTGAAGTTGAACCACAGTCACAGCCACAGCCTTCCCCAGAACTTCTGCTTCCAAATTCTTTGAAGCCAGAAGAA
GGGCTTGAAGTATGGAAAAACTGGGCCCAGACCAAGAATGCTGAACTAGAGAAGGATGCTCAGAACAGATTGGCACCCATTGGGAGGCGC
CAACTGCTGCGATTCCAGGAAGATCTCATCTCCTCTGCTGTGGCAGAGTTGAATTATGGGCTCTGTCTAATGACACGGGAAGCTCGAAAT
GGAGAAGGTGAACCCTATGACCCAGATGTGCTCTACTATATTTTCCTGTGTATTCAAAAGTATCTTTTTGAAAATGGAAGGGTAGATGAC
ATTTTCTCCGATCTTTATTATGTTCGGTTCACGGAGTGGCTACATGAAGTTCTGAAGGATGTTCAGCCCCGGGTCACTCCACTTGGCTAT
GTCTTGCCCAGCCACGTGACTGAGGAGATGCTATGGGAGTGCAAGCAGCTTGGGGCTCACTCCCCCTCCACCTTGCTGACCACCCTCATG
TTCTTTAATACCAAGTACTTCCTATTGAAGACAGTGGACCAGCACATGAAGCTGGCCTTCTCCAAGGTCTTGCGACAGACAAAGAAGAAC
CCCTCTAATCCCAAGGATAAAAGCACGAGTATCCGGTACTTGAAGGCCCTTGGAATACACCAGACTGGCCAGAAAGTTACAGATGACATG
TATGCAGAACAGACGGAAAATCCAGAGAATCCATTGAGATGTCCCATCAAGCTCTATGATTTCTACCTCTTCAAATGCCCCCAGAGTGTG
AAAGGCCGGAATGACACCTTTTACCTGACACCTGAGCCAGTGGTGGCCCCCAACAGCCCAATCTGGTACTCAGTCCAGCCTATCAGCAGA
GAGCAGATGGGACAAATGCTGACGCGGATCCTGGTGATAAGAGAAATTCAGGAGGCCATCGCAGTGGCCAATGCAAGCACTATGCACTGA
GATGCCTTGGCCATGGCACAAGAGAAACCAGCCAGGAAAAACCAGACAGACTTTCACACTAAAGAAGAGGCCTCCATTTTTTTTTTTCTT
TTTTTTATTGGTGTAGTTACGAAGCCTTTCAGGCTGCTTCTGTTTAAAATATAAAAGAAAACTTTGCCCCCTTTGCATCTTCATAAACCT
GCTGCGGCAGACTCCTCAGCCGATGGTGGCTCTGGGTTTCCTTGAGTGTCATATGTCCTAGAAAGTTGCTGGCTGACTCTTTTTTGTCTG
GGGCCTGGGGAAAGGGCTTGGACTGTGAAAAGAAATGTGGCCCCTTTCCATCTTCAAGAGAGATGGAATTAATGATGGATGGACCCTGGA
GGGAATCTCCCCAGCCGACTTCCACTGGGCTGACAGACTTTGCTGACCACAGGGGAACGATGTTCTTTTCTTTCTTCATGATCAGACATA

>73936_73936_7_RHOA-QRICH1_RHOA_chr3_49412866_ENST00000454011_QRICH1_chr3_49084679_ENST00000357496_length(amino acids)=382AA_BP=0
MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQAQTVQVAEVEPQSQPQPSPELLLPNSLKPEEGLEVWKN
WAQTKNAELEKDAQNRLAPIGRRQLLRFQEDLISSAVAELNYGLCLMTREARNGEGEPYDPDVLYYIFLCIQKYLFENGRVDDIFSDLYY
VRFTEWLHEVLKDVQPRVTPLGYVLPSHVTEEMLWECKQLGAHSPSTLLTTLMFFNTKYFLLKTVDQHMKLAFSKVLRQTKKNPSNPKDK
STSIRYLKALGIHQTGQKVTDDMYAEQTENPENPLRCPIKLYDFYLFKCPQSVKGRNDTFYLTPEPVVAPNSPIWYSVQPISREQMGQML

--------------------------------------------------------------
>73936_73936_8_RHOA-QRICH1_RHOA_chr3_49412866_ENST00000454011_QRICH1_chr3_49084679_ENST00000395443_length(transcript)=2005nt_BP=267nt
TCGTTAGTCCACGGTCTGGTCTTCAGCTACCCGCCTTCGTCTCCGAGTTTGCGACTCGCGGACCGGCGTCCCCGGCGCGAAGAGGCTGGA
CTCGGATTCGTTGCCTGAGCAATGGCTGCCATCCGGAAGAAACTGGTGATTGTTGGTGATGGAGCCTGTGGAAAGACATGCTTGCTCATA
GTCTTCAGCAAGGACCAGTTCCCAGAGGTGTATGTGCCCACAGTGTTTGAGAACTATGTGGCAGATATCGAGGTGGATGGAAAGCAGGCT
CAAACTGTCCAGGTTGCTGAAGTTGAACCACAGTCACAGCCACAGCCTTCCCCAGAACTTCTGCTTCCAAATTCTTTGAAGCCAGAAGAA
GGGCTTGAAGTATGGAAAAACTGGGCCCAGACCAAGAATGCTGAACTAGAGAAGGATGCTCAGAACAGATTGGCACCCATTGGGAGGCGC
CAACTGCTGCGATTCCAGGAAGATCTCATCTCCTCTGCTGTGGCAGAGTTGAATTATGGGCTCTGTCTAATGACACGGGAAGCTCGAAAT
GGAGAAGGTGAACCCTATGACCCAGATGTGCTCTACTATATTTTCCTGTGTATTCAAAAGTATCTTTTTGAAAATGGAAGGGTAGATGAC
ATTTTCTCCGATCTTTATTATGTTCGGTTCACGGAGTGGCTACATGAAGTTCTGAAGGATGTTCAGCCCCGGGTCACTCCACTTGGCTAT
GTCTTGCCCAGCCACGTGACTGAGGAGATGCTATGGGAGTGCAAGCAGCTTGGGGCTCACTCCCCCTCCACCTTGCTGACCACCCTCATG
TTCTTTAATACCAAGTACTTCCTATTGAAGACAGTGGACCAGCACATGAAGCTGGCCTTCTCCAAGGTCTTGCGACAGACAAAGAAGAAC
CCCTCTAATCCCAAGGATAAAAGCACGAGTATCCGGTACTTGAAGGCCCTTGGAATACACCAGACTGGCCAGAAAGTTACAGATGACATG
TATGCAGAACAGACGGAAAATCCAGAGAATCCATTGAGATGTCCCATCAAGCTCTATGATTTCTACCTCTTCAAATGCCCCCAGAGTGTG
AAAGGCCGGAATGACACCTTTTACCTGACACCTGAGCCAGTGGTGGCCCCCAACAGCCCAATCTGGTACTCAGTCCAGCCTATCAGCAGA
GAGCAGATGGGACAAATGCTGACGCGGATCCTGGTGATAAGAGAAATTCAGGAGGCCATCGCAGTGGCCAATGCAAGCACTATGCACTGA
GATGCCTTGGCCATGGCACAAGAGAAACCAGCCAGGAAAAACCAGACAGACTTTCACACTAAAGAAGAGGCCTCCATTTTTTTTTTTCTT
TTTTTTATTGGTGTAGTTACGAAGCCTTTCAGGCTGCTTCTGTTTAAAATATAAAAGAAAACTTTGCCCCCTTTGCATCTTCATAAACCT
GCTGCGGCAGACTCCTCAGCCGATGGTGGCTCTGGGTTTCCTTGAGTGTCATATGTCCTAGAAAGTTGCTGGCTGACTCTTTTTTGTCTG
GGGCCTGGGGAAAGGGCTTGGACTGTGAAAAGAAATGTGGCCCCTTTCCATCTTCAAGAGAGATGGAATTAATGATGGATGGACCCTGGA
GGGAATCTCCCCAGCCGACTTCCACTGGGCTGACAGACTTTGCTGACCACAGGGGAACGATGTTCTTTTCTTTCTTCATGATCAGACATA
AACTTAGCATCTTAATGGAAGAAAAATGAGGGGAACTTCAATTATGATTTATTAAAGACAATTTCTATTACACCCTCCTTTATGACAAGT
GACATTTTAGATGTAAAAGTAAAAACTTTACCATGCCTTTTTTTTTTTTGTTGGCCTAACATTGAGGCCTTAAAACCTGAGGCTCCTGTG
CCTGATGGAATTCTTGTAACATACACTTGTGTATCATATAAAGATACCACTCTGTTTCTCTTATGTATTCTTACTCTAGTTGTTTATTAA

>73936_73936_8_RHOA-QRICH1_RHOA_chr3_49412866_ENST00000454011_QRICH1_chr3_49084679_ENST00000395443_length(amino acids)=382AA_BP=0
MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQAQTVQVAEVEPQSQPQPSPELLLPNSLKPEEGLEVWKN
WAQTKNAELEKDAQNRLAPIGRRQLLRFQEDLISSAVAELNYGLCLMTREARNGEGEPYDPDVLYYIFLCIQKYLFENGRVDDIFSDLYY
VRFTEWLHEVLKDVQPRVTPLGYVLPSHVTEEMLWECKQLGAHSPSTLLTTLMFFNTKYFLLKTVDQHMKLAFSKVLRQTKKNPSNPKDK
STSIRYLKALGIHQTGQKVTDDMYAEQTENPENPLRCPIKLYDFYLFKCPQSVKGRNDTFYLTPEPVVAPNSPIWYSVQPISREQMGQML

--------------------------------------------------------------
>73936_73936_9_RHOA-QRICH1_RHOA_chr3_49412866_ENST00000454011_QRICH1_chr3_49084679_ENST00000424300_length(transcript)=1500nt_BP=267nt
TCGTTAGTCCACGGTCTGGTCTTCAGCTACCCGCCTTCGTCTCCGAGTTTGCGACTCGCGGACCGGCGTCCCCGGCGCGAAGAGGCTGGA
CTCGGATTCGTTGCCTGAGCAATGGCTGCCATCCGGAAGAAACTGGTGATTGTTGGTGATGGAGCCTGTGGAAAGACATGCTTGCTCATA
GTCTTCAGCAAGGACCAGTTCCCAGAGGTGTATGTGCCCACAGTGTTTGAGAACTATGTGGCAGATATCGAGGTGGATGGAAAGCAGGCT
CAAACTGTCCAGGTTGCTGAAGTTGAACCACAGTCACAGCCACAGCCTTCCCCAGAACTTCTGCTTCCAAATTCTTTGAAGCCAGAAGAA
GGGCTTGAAGTATGGAAAAACTGGGCCCAGACCAAGAATGCTGAACTAGAGAAGGATGCTCAGAACAGATTGGCACCCATTGGGAGGCGC
CAACTGCTGCGATTCCAGGAAGATCTCATCTCCTCTGCTGTGGCAGAGTTGAATTATGGGCTCTGTCTAATGACACGGGAAGCTCGAAAT
GGAGAAGGTGAACCCTATGACCCAGATGTGCTCTACTATATTTTCCTGTGTATTCAAAAGTATCTTTTTGAAAATGGAAGGGTAGATGAC
ATTTTCTCCGATCTTTATTATGTTCGGTTCACGGAGTGGCTACATGAAGTTCTGAAGGATGTTCAGCCCCGGGTCACTCCACTTGGCTAT
GTCTTGCCCAGCCACGTGACTGAGGAGATGCTATGGGAGTGCAAGCAGCTTGGGGCTCACTCCCCCTCCACCTTGCTGACCACCCTCATG
TTCTTTAATACCAAGTACTTCCTATTGAAGACAGTGGACCAGCACATGAAGCTGGCCTTCTCCAAGGTCTTGCGACAGACAAAGAAGAAC
CCCTCTAATCCCAAGGATAAAAGCACGAGTATCCGGTACTTGAAGGCCCTTGGAATACACCAGACTGGCCAGAAAGTTACAGATGACATG
TATGCAGAACAGACGGAAAATCCAGAGAATCCATTGAGATGTCCCATCAAGCTCTATGATTTCTACCTCTTCAAATGCCCCCAGAGTGTG
AAAGGCCGGAATGACACCTTTTACCTGACACCTGAGCCAGTGGTGGCCCCCAACAGCCCAATCTGGTACTCAGTCCAGCCTATCAGCAGA
GAGCAGATGGGACAAATGCTGACGCGGATCCTGGTGATAAGAGAAATTCAGGAGGCCATCGCAGTGGCCAATGCAAGCACTATGCACTGA
GATGCCTTGGCCATGGCACAAGAGAAACCAGCCAGGAAAAACCAGACAGACTTTCACACTAAAGAAGAGGCCTCCATTTTTTTTTTTCTT
TTTTTTATTGGTGTAGTTACGAAGCCTTTCAGGCTGCTTCTGTTTAAAATATAAAAGAAAACTTTGCCCCCTTTGCATCTTCATAAACCT

>73936_73936_9_RHOA-QRICH1_RHOA_chr3_49412866_ENST00000454011_QRICH1_chr3_49084679_ENST00000424300_length(amino acids)=382AA_BP=0
MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQAQTVQVAEVEPQSQPQPSPELLLPNSLKPEEGLEVWKN
WAQTKNAELEKDAQNRLAPIGRRQLLRFQEDLISSAVAELNYGLCLMTREARNGEGEPYDPDVLYYIFLCIQKYLFENGRVDDIFSDLYY
VRFTEWLHEVLKDVQPRVTPLGYVLPSHVTEEMLWECKQLGAHSPSTLLTTLMFFNTKYFLLKTVDQHMKLAFSKVLRQTKKNPSNPKDK
STSIRYLKALGIHQTGQKVTDDMYAEQTENPENPLRCPIKLYDFYLFKCPQSVKGRNDTFYLTPEPVVAPNSPIWYSVQPISREQMGQML

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for RHOA-QRICH1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for RHOA-QRICH1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for RHOA-QRICH1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source