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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RHOT1-LRRC37B (FusionGDB2 ID:73998)

Fusion Gene Summary for RHOT1-LRRC37B

check button Fusion gene summary
Fusion gene informationFusion gene name: RHOT1-LRRC37B
Fusion gene ID: 73998
HgeneTgene
Gene symbol

RHOT1

LRRC37B

Gene ID

55288

114659

Gene nameras homolog family member T1leucine rich repeat containing 37B
SynonymsARHT1|MIRO-1|MIRO1LRRC37
Cytomap

17q11.2

17q11.2

Type of geneprotein-codingprotein-coding
Descriptionmitochondrial Rho GTPase 1mitochondrial Rho (MIRO) GTPase 1rac-GTP binding protein-like proteinras homolog gene family, member T1leucine-rich repeat-containing protein 37BC66 SLIT-like testicular protein
Modification date2020031320200313
UniProtAcc.

Q96QE4

Ensembl transtripts involved in fusion geneENST00000580976, ENST00000333942, 
ENST00000358365, ENST00000394692, 
ENST00000545287, ENST00000581094, 
ENST00000354266, ENST00000583994, 
ENST00000327564, ENST00000341671, 
ENST00000394713, ENST00000543378, 
ENST00000584368, ENST00000581786, 
Fusion gene scores* DoF score9 X 6 X 5=27013 X 14 X 8=1456
# samples 1015
** MAII scorelog2(10/270*10)=-1.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1456*10)=-3.27897594970282
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RHOT1 [Title/Abstract] AND LRRC37B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRHOT1(30469748)-LRRC37B(30374780), # samples:3
Anticipated loss of major functional domain due to fusion event.RHOT1-LRRC37B seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
RHOT1-LRRC37B seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across RHOT1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LRRC37B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-93-8067-01ARHOT1chr17

30469748

+LRRC37Bchr17

30372719

+
ChimerDB4LUADTCGA-93-8067-01ARHOT1chr17

30469748

-LRRC37Bchr17

30374780

+
ChimerDB4LUADTCGA-93-8067-01ARHOT1chr17

30469748

+LRRC37Bchr17

30374780

+
ChimerDB4LUADTCGA-93-8067RHOT1chr17

30469748

+LRRC37Bchr17

30372718

+


Top

Fusion Gene ORF analysis for RHOT1-LRRC37B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000580976ENST00000327564RHOT1chr17

30469748

+LRRC37Bchr17

30372719

+
3UTR-3CDSENST00000580976ENST00000327564RHOT1chr17

30469748

+LRRC37Bchr17

30374780

+
3UTR-3CDSENST00000580976ENST00000327564RHOT1chr17

30469748

+LRRC37Bchr17

30372718

+
3UTR-3CDSENST00000580976ENST00000341671RHOT1chr17

30469748

+LRRC37Bchr17

30372719

+
3UTR-3CDSENST00000580976ENST00000341671RHOT1chr17

30469748

+LRRC37Bchr17

30374780

+
3UTR-3CDSENST00000580976ENST00000341671RHOT1chr17

30469748

+LRRC37Bchr17

30372718

+
3UTR-3CDSENST00000580976ENST00000394713RHOT1chr17

30469748

+LRRC37Bchr17

30372719

+
3UTR-3CDSENST00000580976ENST00000394713RHOT1chr17

30469748

+LRRC37Bchr17

30374780

+
3UTR-3CDSENST00000580976ENST00000394713RHOT1chr17

30469748

+LRRC37Bchr17

30372718

+
3UTR-3CDSENST00000580976ENST00000543378RHOT1chr17

30469748

+LRRC37Bchr17

30372719

+
3UTR-3CDSENST00000580976ENST00000543378RHOT1chr17

30469748

+LRRC37Bchr17

30374780

+
3UTR-3CDSENST00000580976ENST00000543378RHOT1chr17

30469748

+LRRC37Bchr17

30372718

+
3UTR-3CDSENST00000580976ENST00000584368RHOT1chr17

30469748

+LRRC37Bchr17

30372719

+
3UTR-3CDSENST00000580976ENST00000584368RHOT1chr17

30469748

+LRRC37Bchr17

30374780

+
3UTR-3CDSENST00000580976ENST00000584368RHOT1chr17

30469748

+LRRC37Bchr17

30372718

+
3UTR-intronENST00000580976ENST00000581786RHOT1chr17

30469748

+LRRC37Bchr17

30372719

+
3UTR-intronENST00000580976ENST00000581786RHOT1chr17

30469748

+LRRC37Bchr17

30374780

+
3UTR-intronENST00000580976ENST00000581786RHOT1chr17

30469748

+LRRC37Bchr17

30372718

+
5CDS-intronENST00000333942ENST00000581786RHOT1chr17

30469748

+LRRC37Bchr17

30372719

+
5CDS-intronENST00000333942ENST00000581786RHOT1chr17

30469748

+LRRC37Bchr17

30374780

+
5CDS-intronENST00000333942ENST00000581786RHOT1chr17

30469748

+LRRC37Bchr17

30372718

+
5CDS-intronENST00000358365ENST00000581786RHOT1chr17

30469748

+LRRC37Bchr17

30372719

+
5CDS-intronENST00000358365ENST00000581786RHOT1chr17

30469748

+LRRC37Bchr17

30374780

+
5CDS-intronENST00000358365ENST00000581786RHOT1chr17

30469748

+LRRC37Bchr17

30372718

+
5CDS-intronENST00000394692ENST00000581786RHOT1chr17

30469748

+LRRC37Bchr17

30372719

+
5CDS-intronENST00000394692ENST00000581786RHOT1chr17

30469748

+LRRC37Bchr17

30374780

+
5CDS-intronENST00000394692ENST00000581786RHOT1chr17

30469748

+LRRC37Bchr17

30372718

+
5CDS-intronENST00000545287ENST00000581786RHOT1chr17

30469748

+LRRC37Bchr17

30372719

+
5CDS-intronENST00000545287ENST00000581786RHOT1chr17

30469748

+LRRC37Bchr17

30374780

+
5CDS-intronENST00000545287ENST00000581786RHOT1chr17

30469748

+LRRC37Bchr17

30372718

+
5CDS-intronENST00000581094ENST00000581786RHOT1chr17

30469748

+LRRC37Bchr17

30372719

+
5CDS-intronENST00000581094ENST00000581786RHOT1chr17

30469748

+LRRC37Bchr17

30374780

+
5CDS-intronENST00000581094ENST00000581786RHOT1chr17

30469748

+LRRC37Bchr17

30372718

+
5UTR-3CDSENST00000354266ENST00000327564RHOT1chr17

30469748

+LRRC37Bchr17

30372719

+
5UTR-3CDSENST00000354266ENST00000327564RHOT1chr17

30469748

+LRRC37Bchr17

30374780

+
5UTR-3CDSENST00000354266ENST00000327564RHOT1chr17

30469748

+LRRC37Bchr17

30372718

+
5UTR-3CDSENST00000354266ENST00000341671RHOT1chr17

30469748

+LRRC37Bchr17

30372719

+
5UTR-3CDSENST00000354266ENST00000341671RHOT1chr17

30469748

+LRRC37Bchr17

30374780

+
5UTR-3CDSENST00000354266ENST00000341671RHOT1chr17

30469748

+LRRC37Bchr17

30372718

+
5UTR-3CDSENST00000354266ENST00000394713RHOT1chr17

30469748

+LRRC37Bchr17

30372719

+
5UTR-3CDSENST00000354266ENST00000394713RHOT1chr17

30469748

+LRRC37Bchr17

30374780

+
5UTR-3CDSENST00000354266ENST00000394713RHOT1chr17

30469748

+LRRC37Bchr17

30372718

+
5UTR-3CDSENST00000354266ENST00000543378RHOT1chr17

30469748

+LRRC37Bchr17

30372719

+
5UTR-3CDSENST00000354266ENST00000543378RHOT1chr17

30469748

+LRRC37Bchr17

30374780

+
5UTR-3CDSENST00000354266ENST00000543378RHOT1chr17

30469748

+LRRC37Bchr17

30372718

+
5UTR-3CDSENST00000354266ENST00000584368RHOT1chr17

30469748

+LRRC37Bchr17

30372719

+
5UTR-3CDSENST00000354266ENST00000584368RHOT1chr17

30469748

+LRRC37Bchr17

30374780

+
5UTR-3CDSENST00000354266ENST00000584368RHOT1chr17

30469748

+LRRC37Bchr17

30372718

+
5UTR-3CDSENST00000583994ENST00000327564RHOT1chr17

30469748

+LRRC37Bchr17

30372719

+
5UTR-3CDSENST00000583994ENST00000327564RHOT1chr17

30469748

+LRRC37Bchr17

30374780

+
5UTR-3CDSENST00000583994ENST00000327564RHOT1chr17

30469748

+LRRC37Bchr17

30372718

+
5UTR-3CDSENST00000583994ENST00000341671RHOT1chr17

30469748

+LRRC37Bchr17

30372719

+
5UTR-3CDSENST00000583994ENST00000341671RHOT1chr17

30469748

+LRRC37Bchr17

30374780

+
5UTR-3CDSENST00000583994ENST00000341671RHOT1chr17

30469748

+LRRC37Bchr17

30372718

+
5UTR-3CDSENST00000583994ENST00000394713RHOT1chr17

30469748

+LRRC37Bchr17

30372719

+
5UTR-3CDSENST00000583994ENST00000394713RHOT1chr17

30469748

+LRRC37Bchr17

30374780

+
5UTR-3CDSENST00000583994ENST00000394713RHOT1chr17

30469748

+LRRC37Bchr17

30372718

+
5UTR-3CDSENST00000583994ENST00000543378RHOT1chr17

30469748

+LRRC37Bchr17

30372719

+
5UTR-3CDSENST00000583994ENST00000543378RHOT1chr17

30469748

+LRRC37Bchr17

30374780

+
5UTR-3CDSENST00000583994ENST00000543378RHOT1chr17

30469748

+LRRC37Bchr17

30372718

+
5UTR-3CDSENST00000583994ENST00000584368RHOT1chr17

30469748

+LRRC37Bchr17

30372719

+
5UTR-3CDSENST00000583994ENST00000584368RHOT1chr17

30469748

+LRRC37Bchr17

30374780

+
5UTR-3CDSENST00000583994ENST00000584368RHOT1chr17

30469748

+LRRC37Bchr17

30372718

+
5UTR-intronENST00000354266ENST00000581786RHOT1chr17

30469748

+LRRC37Bchr17

30372719

+
5UTR-intronENST00000354266ENST00000581786RHOT1chr17

30469748

+LRRC37Bchr17

30374780

+
5UTR-intronENST00000354266ENST00000581786RHOT1chr17

30469748

+LRRC37Bchr17

30372718

+
5UTR-intronENST00000583994ENST00000581786RHOT1chr17

30469748

+LRRC37Bchr17

30372719

+
5UTR-intronENST00000583994ENST00000581786RHOT1chr17

30469748

+LRRC37Bchr17

30374780

+
5UTR-intronENST00000583994ENST00000581786RHOT1chr17

30469748

+LRRC37Bchr17

30372718

+
Frame-shiftENST00000333942ENST00000327564RHOT1chr17

30469748

+LRRC37Bchr17

30372719

+
Frame-shiftENST00000333942ENST00000327564RHOT1chr17

30469748

+LRRC37Bchr17

30372718

+
Frame-shiftENST00000333942ENST00000341671RHOT1chr17

30469748

+LRRC37Bchr17

30372719

+
Frame-shiftENST00000333942ENST00000341671RHOT1chr17

30469748

+LRRC37Bchr17

30372718

+
Frame-shiftENST00000333942ENST00000394713RHOT1chr17

30469748

+LRRC37Bchr17

30372719

+
Frame-shiftENST00000333942ENST00000394713RHOT1chr17

30469748

+LRRC37Bchr17

30372718

+
Frame-shiftENST00000333942ENST00000543378RHOT1chr17

30469748

+LRRC37Bchr17

30372719

+
Frame-shiftENST00000333942ENST00000543378RHOT1chr17

30469748

+LRRC37Bchr17

30372718

+
Frame-shiftENST00000333942ENST00000584368RHOT1chr17

30469748

+LRRC37Bchr17

30372719

+
Frame-shiftENST00000333942ENST00000584368RHOT1chr17

30469748

+LRRC37Bchr17

30372718

+
Frame-shiftENST00000358365ENST00000327564RHOT1chr17

30469748

+LRRC37Bchr17

30372719

+
Frame-shiftENST00000358365ENST00000327564RHOT1chr17

30469748

+LRRC37Bchr17

30372718

+
Frame-shiftENST00000358365ENST00000341671RHOT1chr17

30469748

+LRRC37Bchr17

30372719

+
Frame-shiftENST00000358365ENST00000341671RHOT1chr17

30469748

+LRRC37Bchr17

30372718

+
Frame-shiftENST00000358365ENST00000394713RHOT1chr17

30469748

+LRRC37Bchr17

30372719

+
Frame-shiftENST00000358365ENST00000394713RHOT1chr17

30469748

+LRRC37Bchr17

30372718

+
Frame-shiftENST00000358365ENST00000543378RHOT1chr17

30469748

+LRRC37Bchr17

30372719

+
Frame-shiftENST00000358365ENST00000543378RHOT1chr17

30469748

+LRRC37Bchr17

30372718

+
Frame-shiftENST00000358365ENST00000584368RHOT1chr17

30469748

+LRRC37Bchr17

30372719

+
Frame-shiftENST00000358365ENST00000584368RHOT1chr17

30469748

+LRRC37Bchr17

30372718

+
Frame-shiftENST00000394692ENST00000327564RHOT1chr17

30469748

+LRRC37Bchr17

30372719

+
Frame-shiftENST00000394692ENST00000327564RHOT1chr17

30469748

+LRRC37Bchr17

30372718

+
Frame-shiftENST00000394692ENST00000341671RHOT1chr17

30469748

+LRRC37Bchr17

30372719

+
Frame-shiftENST00000394692ENST00000341671RHOT1chr17

30469748

+LRRC37Bchr17

30372718

+
Frame-shiftENST00000394692ENST00000394713RHOT1chr17

30469748

+LRRC37Bchr17

30372719

+
Frame-shiftENST00000394692ENST00000394713RHOT1chr17

30469748

+LRRC37Bchr17

30372718

+
Frame-shiftENST00000394692ENST00000543378RHOT1chr17

30469748

+LRRC37Bchr17

30372719

+
Frame-shiftENST00000394692ENST00000543378RHOT1chr17

30469748

+LRRC37Bchr17

30372718

+
Frame-shiftENST00000394692ENST00000584368RHOT1chr17

30469748

+LRRC37Bchr17

30372719

+
Frame-shiftENST00000394692ENST00000584368RHOT1chr17

30469748

+LRRC37Bchr17

30372718

+
Frame-shiftENST00000545287ENST00000327564RHOT1chr17

30469748

+LRRC37Bchr17

30372719

+
Frame-shiftENST00000545287ENST00000327564RHOT1chr17

30469748

+LRRC37Bchr17

30372718

+
Frame-shiftENST00000545287ENST00000341671RHOT1chr17

30469748

+LRRC37Bchr17

30372719

+
Frame-shiftENST00000545287ENST00000341671RHOT1chr17

30469748

+LRRC37Bchr17

30372718

+
Frame-shiftENST00000545287ENST00000394713RHOT1chr17

30469748

+LRRC37Bchr17

30372719

+
Frame-shiftENST00000545287ENST00000394713RHOT1chr17

30469748

+LRRC37Bchr17

30372718

+
Frame-shiftENST00000545287ENST00000543378RHOT1chr17

30469748

+LRRC37Bchr17

30372719

+
Frame-shiftENST00000545287ENST00000543378RHOT1chr17

30469748

+LRRC37Bchr17

30372718

+
Frame-shiftENST00000545287ENST00000584368RHOT1chr17

30469748

+LRRC37Bchr17

30372719

+
Frame-shiftENST00000545287ENST00000584368RHOT1chr17

30469748

+LRRC37Bchr17

30372718

+
Frame-shiftENST00000581094ENST00000327564RHOT1chr17

30469748

+LRRC37Bchr17

30372719

+
Frame-shiftENST00000581094ENST00000327564RHOT1chr17

30469748

+LRRC37Bchr17

30372718

+
Frame-shiftENST00000581094ENST00000341671RHOT1chr17

30469748

+LRRC37Bchr17

30372719

+
Frame-shiftENST00000581094ENST00000341671RHOT1chr17

30469748

+LRRC37Bchr17

30372718

+
Frame-shiftENST00000581094ENST00000394713RHOT1chr17

30469748

+LRRC37Bchr17

30372719

+
Frame-shiftENST00000581094ENST00000394713RHOT1chr17

30469748

+LRRC37Bchr17

30372718

+
Frame-shiftENST00000581094ENST00000543378RHOT1chr17

30469748

+LRRC37Bchr17

30372719

+
Frame-shiftENST00000581094ENST00000543378RHOT1chr17

30469748

+LRRC37Bchr17

30372718

+
Frame-shiftENST00000581094ENST00000584368RHOT1chr17

30469748

+LRRC37Bchr17

30372719

+
Frame-shiftENST00000581094ENST00000584368RHOT1chr17

30469748

+LRRC37Bchr17

30372718

+
In-frameENST00000333942ENST00000327564RHOT1chr17

30469748

+LRRC37Bchr17

30374780

+
In-frameENST00000333942ENST00000341671RHOT1chr17

30469748

+LRRC37Bchr17

30374780

+
In-frameENST00000333942ENST00000394713RHOT1chr17

30469748

+LRRC37Bchr17

30374780

+
In-frameENST00000333942ENST00000543378RHOT1chr17

30469748

+LRRC37Bchr17

30374780

+
In-frameENST00000333942ENST00000584368RHOT1chr17

30469748

+LRRC37Bchr17

30374780

+
In-frameENST00000358365ENST00000327564RHOT1chr17

30469748

+LRRC37Bchr17

30374780

+
In-frameENST00000358365ENST00000341671RHOT1chr17

30469748

+LRRC37Bchr17

30374780

+
In-frameENST00000358365ENST00000394713RHOT1chr17

30469748

+LRRC37Bchr17

30374780

+
In-frameENST00000358365ENST00000543378RHOT1chr17

30469748

+LRRC37Bchr17

30374780

+
In-frameENST00000358365ENST00000584368RHOT1chr17

30469748

+LRRC37Bchr17

30374780

+
In-frameENST00000394692ENST00000327564RHOT1chr17

30469748

+LRRC37Bchr17

30374780

+
In-frameENST00000394692ENST00000341671RHOT1chr17

30469748

+LRRC37Bchr17

30374780

+
In-frameENST00000394692ENST00000394713RHOT1chr17

30469748

+LRRC37Bchr17

30374780

+
In-frameENST00000394692ENST00000543378RHOT1chr17

30469748

+LRRC37Bchr17

30374780

+
In-frameENST00000394692ENST00000584368RHOT1chr17

30469748

+LRRC37Bchr17

30374780

+
In-frameENST00000545287ENST00000327564RHOT1chr17

30469748

+LRRC37Bchr17

30374780

+
In-frameENST00000545287ENST00000341671RHOT1chr17

30469748

+LRRC37Bchr17

30374780

+
In-frameENST00000545287ENST00000394713RHOT1chr17

30469748

+LRRC37Bchr17

30374780

+
In-frameENST00000545287ENST00000543378RHOT1chr17

30469748

+LRRC37Bchr17

30374780

+
In-frameENST00000545287ENST00000584368RHOT1chr17

30469748

+LRRC37Bchr17

30374780

+
In-frameENST00000581094ENST00000327564RHOT1chr17

30469748

+LRRC37Bchr17

30374780

+
In-frameENST00000581094ENST00000341671RHOT1chr17

30469748

+LRRC37Bchr17

30374780

+
In-frameENST00000581094ENST00000394713RHOT1chr17

30469748

+LRRC37Bchr17

30374780

+
In-frameENST00000581094ENST00000543378RHOT1chr17

30469748

+LRRC37Bchr17

30374780

+
In-frameENST00000581094ENST00000584368RHOT1chr17

30469748

+LRRC37Bchr17

30374780

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for RHOT1-LRRC37B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RHOT1chr1730469748+LRRC37Bchr1730374779+7.04E-111
RHOT1chr1730469748+LRRC37Bchr1730372718+6.07E-101
RHOT1chr1730469748+LRRC37Bchr1730372718+6.07E-101
RHOT1chr1730469748+LRRC37Bchr1730374779+7.04E-111
RHOT1chr1730469748+LRRC37Bchr1730372718+6.07E-101
RHOT1chr1730469748+LRRC37Bchr1730372718+6.07E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for RHOT1-LRRC37B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:30469748/chr17:30374780)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.LRRC37B

Q96QE4

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLRRC37Bchr17:30469748chr17:30374780ENST00000341671712867_897747948.0Coiled coilOntology_term=ECO:0000255
TgeneLRRC37Bchr17:30469748chr17:30374780ENST00000341671712927_947747948.0Topological domainCytoplasmic
TgeneLRRC37Bchr17:30469748chr17:30374780ENST00000341671712906_926747948.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRHOT1chr17:30469748chr17:30374780ENST00000333942+119197_20812619.0Calcium binding1
HgeneRHOT1chr17:30469748chr17:30374780ENST00000333942+119317_32812619.0Calcium binding2
HgeneRHOT1chr17:30469748chr17:30374780ENST00000358365+121197_20812692.0Calcium binding1
HgeneRHOT1chr17:30469748chr17:30374780ENST00000358365+121317_32812692.0Calcium binding2
HgeneRHOT1chr17:30469748chr17:30374780ENST00000394692+120197_20812651.0Calcium binding1
HgeneRHOT1chr17:30469748chr17:30374780ENST00000394692+120317_32812651.0Calcium binding2
HgeneRHOT1chr17:30469748chr17:30374780ENST00000545287+120197_20812660.0Calcium binding1
HgeneRHOT1chr17:30469748chr17:30374780ENST00000545287+120317_32812660.0Calcium binding2
HgeneRHOT1chr17:30469748chr17:30374780ENST00000581094+118197_20812581.0Calcium binding1
HgeneRHOT1chr17:30469748chr17:30374780ENST00000581094+118317_32812581.0Calcium binding2
HgeneRHOT1chr17:30469748chr17:30374780ENST00000333942+119184_21912619.0DomainEF-hand 1
HgeneRHOT1chr17:30469748chr17:30374780ENST00000333942+1192_16812619.0DomainMiro 1
HgeneRHOT1chr17:30469748chr17:30374780ENST00000333942+119304_33912619.0DomainEF-hand 2
HgeneRHOT1chr17:30469748chr17:30374780ENST00000333942+119416_57912619.0DomainMiro 2
HgeneRHOT1chr17:30469748chr17:30374780ENST00000358365+121184_21912692.0DomainEF-hand 1
HgeneRHOT1chr17:30469748chr17:30374780ENST00000358365+1212_16812692.0DomainMiro 1
HgeneRHOT1chr17:30469748chr17:30374780ENST00000358365+121304_33912692.0DomainEF-hand 2
HgeneRHOT1chr17:30469748chr17:30374780ENST00000358365+121416_57912692.0DomainMiro 2
HgeneRHOT1chr17:30469748chr17:30374780ENST00000394692+120184_21912651.0DomainEF-hand 1
HgeneRHOT1chr17:30469748chr17:30374780ENST00000394692+1202_16812651.0DomainMiro 1
HgeneRHOT1chr17:30469748chr17:30374780ENST00000394692+120304_33912651.0DomainEF-hand 2
HgeneRHOT1chr17:30469748chr17:30374780ENST00000394692+120416_57912651.0DomainMiro 2
HgeneRHOT1chr17:30469748chr17:30374780ENST00000545287+120184_21912660.0DomainEF-hand 1
HgeneRHOT1chr17:30469748chr17:30374780ENST00000545287+1202_16812660.0DomainMiro 1
HgeneRHOT1chr17:30469748chr17:30374780ENST00000545287+120304_33912660.0DomainEF-hand 2
HgeneRHOT1chr17:30469748chr17:30374780ENST00000545287+120416_57912660.0DomainMiro 2
HgeneRHOT1chr17:30469748chr17:30374780ENST00000581094+118184_21912581.0DomainEF-hand 1
HgeneRHOT1chr17:30469748chr17:30374780ENST00000581094+1182_16812581.0DomainMiro 1
HgeneRHOT1chr17:30469748chr17:30374780ENST00000581094+118304_33912581.0DomainEF-hand 2
HgeneRHOT1chr17:30469748chr17:30374780ENST00000581094+118416_57912581.0DomainMiro 2
HgeneRHOT1chr17:30469748chr17:30374780ENST00000333942+119118_12112619.0Nucleotide bindingGTP 1
HgeneRHOT1chr17:30469748chr17:30374780ENST00000333942+11911_1812619.0Nucleotide bindingNote=GTP 1
HgeneRHOT1chr17:30469748chr17:30374780ENST00000333942+119425_43212619.0Nucleotide bindingNote=GTP 2
HgeneRHOT1chr17:30469748chr17:30374780ENST00000333942+119463_46712619.0Nucleotide bindingGTP 2
HgeneRHOT1chr17:30469748chr17:30374780ENST00000333942+119527_53012619.0Nucleotide bindingGTP 2
HgeneRHOT1chr17:30469748chr17:30374780ENST00000333942+11957_6112619.0Nucleotide bindingGTP 1
HgeneRHOT1chr17:30469748chr17:30374780ENST00000358365+121118_12112692.0Nucleotide bindingGTP 1
HgeneRHOT1chr17:30469748chr17:30374780ENST00000358365+12111_1812692.0Nucleotide bindingNote=GTP 1
HgeneRHOT1chr17:30469748chr17:30374780ENST00000358365+121425_43212692.0Nucleotide bindingNote=GTP 2
HgeneRHOT1chr17:30469748chr17:30374780ENST00000358365+121463_46712692.0Nucleotide bindingGTP 2
HgeneRHOT1chr17:30469748chr17:30374780ENST00000358365+121527_53012692.0Nucleotide bindingGTP 2
HgeneRHOT1chr17:30469748chr17:30374780ENST00000358365+12157_6112692.0Nucleotide bindingGTP 1
HgeneRHOT1chr17:30469748chr17:30374780ENST00000394692+120118_12112651.0Nucleotide bindingGTP 1
HgeneRHOT1chr17:30469748chr17:30374780ENST00000394692+12011_1812651.0Nucleotide bindingNote=GTP 1
HgeneRHOT1chr17:30469748chr17:30374780ENST00000394692+120425_43212651.0Nucleotide bindingNote=GTP 2
HgeneRHOT1chr17:30469748chr17:30374780ENST00000394692+120463_46712651.0Nucleotide bindingGTP 2
HgeneRHOT1chr17:30469748chr17:30374780ENST00000394692+120527_53012651.0Nucleotide bindingGTP 2
HgeneRHOT1chr17:30469748chr17:30374780ENST00000394692+12057_6112651.0Nucleotide bindingGTP 1
HgeneRHOT1chr17:30469748chr17:30374780ENST00000545287+120118_12112660.0Nucleotide bindingGTP 1
HgeneRHOT1chr17:30469748chr17:30374780ENST00000545287+12011_1812660.0Nucleotide bindingNote=GTP 1
HgeneRHOT1chr17:30469748chr17:30374780ENST00000545287+120425_43212660.0Nucleotide bindingNote=GTP 2
HgeneRHOT1chr17:30469748chr17:30374780ENST00000545287+120463_46712660.0Nucleotide bindingGTP 2
HgeneRHOT1chr17:30469748chr17:30374780ENST00000545287+120527_53012660.0Nucleotide bindingGTP 2
HgeneRHOT1chr17:30469748chr17:30374780ENST00000545287+12057_6112660.0Nucleotide bindingGTP 1
HgeneRHOT1chr17:30469748chr17:30374780ENST00000581094+118118_12112581.0Nucleotide bindingGTP 1
HgeneRHOT1chr17:30469748chr17:30374780ENST00000581094+11811_1812581.0Nucleotide bindingNote=GTP 1
HgeneRHOT1chr17:30469748chr17:30374780ENST00000581094+118425_43212581.0Nucleotide bindingNote=GTP 2
HgeneRHOT1chr17:30469748chr17:30374780ENST00000581094+118463_46712581.0Nucleotide bindingGTP 2
HgeneRHOT1chr17:30469748chr17:30374780ENST00000581094+118527_53012581.0Nucleotide bindingGTP 2
HgeneRHOT1chr17:30469748chr17:30374780ENST00000581094+11857_6112581.0Nucleotide bindingGTP 1
HgeneRHOT1chr17:30469748chr17:30374780ENST00000333942+1191_59212619.0Topological domainCytoplasmic
HgeneRHOT1chr17:30469748chr17:30374780ENST00000333942+119616_61812619.0Topological domainMitochondrial intermembrane
HgeneRHOT1chr17:30469748chr17:30374780ENST00000358365+1211_59212692.0Topological domainCytoplasmic
HgeneRHOT1chr17:30469748chr17:30374780ENST00000358365+121616_61812692.0Topological domainMitochondrial intermembrane
HgeneRHOT1chr17:30469748chr17:30374780ENST00000394692+1201_59212651.0Topological domainCytoplasmic
HgeneRHOT1chr17:30469748chr17:30374780ENST00000394692+120616_61812651.0Topological domainMitochondrial intermembrane
HgeneRHOT1chr17:30469748chr17:30374780ENST00000545287+1201_59212660.0Topological domainCytoplasmic
HgeneRHOT1chr17:30469748chr17:30374780ENST00000545287+120616_61812660.0Topological domainMitochondrial intermembrane
HgeneRHOT1chr17:30469748chr17:30374780ENST00000581094+1181_59212581.0Topological domainCytoplasmic
HgeneRHOT1chr17:30469748chr17:30374780ENST00000581094+118616_61812581.0Topological domainMitochondrial intermembrane
HgeneRHOT1chr17:30469748chr17:30374780ENST00000333942+119593_61512619.0TransmembraneHelical%3B Anchor for type IV membrane protein
HgeneRHOT1chr17:30469748chr17:30374780ENST00000358365+121593_61512692.0TransmembraneHelical%3B Anchor for type IV membrane protein
HgeneRHOT1chr17:30469748chr17:30374780ENST00000394692+120593_61512651.0TransmembraneHelical%3B Anchor for type IV membrane protein
HgeneRHOT1chr17:30469748chr17:30374780ENST00000545287+120593_61512660.0TransmembraneHelical%3B Anchor for type IV membrane protein
HgeneRHOT1chr17:30469748chr17:30374780ENST00000581094+118593_61512581.0TransmembraneHelical%3B Anchor for type IV membrane protein
TgeneLRRC37Bchr17:30469748chr17:30374780ENST00000341671712556_577747948.0RepeatNote=LRR 1
TgeneLRRC37Bchr17:30469748chr17:30374780ENST00000341671712580_601747948.0RepeatNote=LRR 2
TgeneLRRC37Bchr17:30469748chr17:30374780ENST00000341671712604_625747948.0RepeatNote=LRR 3
TgeneLRRC37Bchr17:30469748chr17:30374780ENST00000341671712628_649747948.0RepeatNote=LRR 4
TgeneLRRC37Bchr17:30469748chr17:30374780ENST00000341671712655_676747948.0RepeatNote=LRR 5
TgeneLRRC37Bchr17:30469748chr17:30374780ENST00000341671712679_699747948.0RepeatNote=LRR 6
TgeneLRRC37Bchr17:30469748chr17:30374780ENST0000034167171228_905747948.0Topological domainExtracellular


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Fusion Gene Sequence for RHOT1-LRRC37B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for RHOT1-LRRC37B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RHOT1-LRRC37B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RHOT1-LRRC37B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource