Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:RICTOR-RANBP3L (FusionGDB2 ID:74077)

Fusion Gene Summary for RICTOR-RANBP3L

Fusion gene summary

Fusion gene information	Fusion gene name: RICTOR-RANBP3L
	Fusion gene ID: 74077
		Hgene	Tgene
	Gene symbol	RICTOR	RANBP3L
	Gene ID	253260	202151
	Gene name	RPTOR independent companion of MTOR complex 2	RAN binding protein 3 like
	Synonyms	AVO3\|PIA\|hAVO3	-
	Cytomap	5p13.1	5p13.2
	Type of gene	protein-coding	protein-coding
	Description	rapamycin-insensitive companion of mTORAVO3 homologTORC2-specific protein AVO3pianissimo	ran-binding protein 3-like
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000296782, ENST00000357387, ENST00000503698,	ENST00000296604, ENST00000502994, ENST00000515759,
Fusion gene scores	* DoF score	19 X 9 X 12=2052	3 X 1 X 2=6
	# samples	20	3
	** MAII score	log2(20/2052*10)=-3.35895882583233 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/6*10)=2.32192809488736
Context	PubMed: RICTOR [Title/Abstract] AND RANBP3L [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	RICTOR(39074213)-RANBP3L(36271413), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RICTOR	GO:0051896	regulation of protein kinase B signaling	15718470

Fusion gene breakpoints across RICTOR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RANBP3L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-D8-A13Z-01A	RICTOR	chr5	39074213	-	RANBP3L	chr5	36271413	-

Top

Fusion Gene ORF analysis for RICTOR-RANBP3L

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000296782	ENST00000296604	RICTOR	chr5	39074213	-	RANBP3L	chr5	36271413	-
In-frame	ENST00000296782	ENST00000502994	RICTOR	chr5	39074213	-	RANBP3L	chr5	36271413	-
In-frame	ENST00000296782	ENST00000515759	RICTOR	chr5	39074213	-	RANBP3L	chr5	36271413	-
In-frame	ENST00000357387	ENST00000296604	RICTOR	chr5	39074213	-	RANBP3L	chr5	36271413	-
In-frame	ENST00000357387	ENST00000502994	RICTOR	chr5	39074213	-	RANBP3L	chr5	36271413	-
In-frame	ENST00000357387	ENST00000515759	RICTOR	chr5	39074213	-	RANBP3L	chr5	36271413	-
intron-3CDS	ENST00000503698	ENST00000296604	RICTOR	chr5	39074213	-	RANBP3L	chr5	36271413	-
intron-3CDS	ENST00000503698	ENST00000502994	RICTOR	chr5	39074213	-	RANBP3L	chr5	36271413	-
intron-3CDS	ENST00000503698	ENST00000515759	RICTOR	chr5	39074213	-	RANBP3L	chr5	36271413	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000357387	RICTOR	chr5	39074213	-	ENST00000296604	RANBP3L	chr5	36271413	-	2655	128	16	1434	472
ENST00000357387	RICTOR	chr5	39074213	-	ENST00000502994	RANBP3L	chr5	36271413	-	1831	128	16	1509	497
ENST00000357387	RICTOR	chr5	39074213	-	ENST00000515759	RANBP3L	chr5	36271413	-	1085	128	16	1002	328
ENST00000296782	RICTOR	chr5	39074213	-	ENST00000296604	RANBP3L	chr5	36271413	-	2646	119	7	1425	472
ENST00000296782	RICTOR	chr5	39074213	-	ENST00000502994	RANBP3L	chr5	36271413	-	1822	119	7	1500	497
ENST00000296782	RICTOR	chr5	39074213	-	ENST00000515759	RANBP3L	chr5	36271413	-	1076	119	7	993	328

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000357387	ENST00000296604	RICTOR	chr5	39074213	-	RANBP3L	chr5	36271413	-	0.000233239	0.99976677
ENST00000357387	ENST00000502994	RICTOR	chr5	39074213	-	RANBP3L	chr5	36271413	-	0.00057148	0.99942845
ENST00000357387	ENST00000515759	RICTOR	chr5	39074213	-	RANBP3L	chr5	36271413	-	0.000741938	0.9992581
ENST00000296782	ENST00000296604	RICTOR	chr5	39074213	-	RANBP3L	chr5	36271413	-	0.000241471	0.99975854
ENST00000296782	ENST00000502994	RICTOR	chr5	39074213	-	RANBP3L	chr5	36271413	-	0.000612283	0.99938774
ENST00000296782	ENST00000515759	RICTOR	chr5	39074213	-	RANBP3L	chr5	36271413	-	0.00078704	0.999213

Top

Fusion Genomic Features for RICTOR-RANBP3L

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for RICTOR-RANBP3L

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:39074213/chr5:36271413)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

RANBP3L

chr5:39074213

chr5:36271413

ENST00000296604

276_417

466.0

Domain

RanBD1

Tgene

RANBP3L

chr5:39074213

chr5:36271413

ENST00000502994

276_417

491.0

Domain

RanBD1

Tgene

RANBP3L

chr5:39074213

chr5:36271413

ENST00000515759

276_417

322.0

Domain

RanBD1

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RICTOR

chr5:39074213

chr5:36271413

ENST00000296782

1016_1058

1733.0

Compositional bias

Ser-rich

Hgene

RICTOR

chr5:39074213

chr5:36271413

ENST00000357387

1016_1058

1709.0

Compositional bias

Ser-rich

Top

Fusion Gene Sequence for RICTOR-RANBP3L

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>74077_74077_1_RICTOR-RANBP3L_RICTOR_chr5_39074213_ENST00000296782_RANBP3L_chr5_36271413_ENST00000296604_length(transcript)=2646nt_BP=119nt
GTTGTGACTGAAACCCGTCAATATGGCGGCGATCGGCCGCGGCCGCTCTCTGAAGAACCTCCGAGTACGAGGGCGGAATGACAGCGGCGA
GGAGAACGTCCCGCTGGATCTGACCCGAGAAAAATCTGTCATTGCTCAACCCATATTTGTTTTTGAAAAGGGAGAACAAACTTTTAAGAG
ACCTGCAGAAGACACCCTGTATGAAGCAGCAGAACCAGAATGTAATGGTTTTCCAACAAAGCGTGTACGGTCTTCATCTTTTACTTTTCA
TATTACAGATTCTCAGTCCCAGGGAGTGAGGAAAAACAATGTTTTTATGACATCAGCTCTTGTGCAAAGTAGTGTTGATATAAAGAGTGC
TGAACAAGGTCCTGTGAAACATTCTAAACATGTTATTAGACCTGCTATTTTGCAGCTACCTCAAGCTCGAAGTTGTGCAAAAGTAAGAAA
AACATTTGGACACAAGGCACTGGAATCTTGCAAGACTAAAGAAAAAACAAATAATAAGATTTCTGAGGGAAATTCCTATTTGTTAAGTGA
AAATTTATCAAGGGCTAGAATTTCAGTCCAGCTGTCTACTAACCAGGACTTTTTAGGTGCAACATCAGTAGGATGTCAACCAAATGAAGA
TAAATGTTCTTTTAAAAGCTGCAGTTCCAATTTTGTTTTTGGAGAAAACATGGTAGAAAGAGTTTTGGGTACTCAAAAACTCACCCAGCC
TCAACTTGAAAATGATTCATATGCCAAGGAAAAACCATTCAAATCCATTCCGAAATTTCCTGTCAACTTTTTAAGTTCAAGAACAGACTC
TATTAAAAATACTTCCCTAATTGAATCAGCTGCTGCATTCTCTTCCCAACCATCACGAAAATGCTTGCTGGAGAAAATTGATGTTATAAC
AGGGGAGGAAACAGAACATAATGTGTTAAAGATAAACTGCAAGCTTTTCATATTCAACAAAACAACACAATCCTGGATTGAAAGGGGCAG
AGGAACGTTGAGACTGAATGACACAGCAAGCACTGACTGTGGAACATTACAGTCAAGACTAATTATGCGCAATCAAGGCAGTCTAAGGCT
GATCCTCAACAGCAAACTCTGGGCCCAAATGAAGATTCAAAGAGCAAACCACAAAAATGTACGAATAACAGCTACTGATTTAGAAGACTA
TAGCATCAAAATATTTTTAATTCAGGCCAGTGCCCAAGATACAGCATATTTGTATGCAGCAATACATCATCGTCTTGTTGCACTTCAAAG
CTTCAATAAGCAGAGAGATGTCAATCAAGCTGAAAGCCTGTCAGAAACAGCCCAACAATTGAACTGCGAAAGCTGTGATGAGAATGAGGA
TGATTTCATCCAAGTCACTAAAAATGGATCAGATCCTTCTAGTTGGACTCACAGACAGTCGGTTGCCTGTTCATGAATACTACCTACTAT
AAACATGACATCTACAAAAAGAGGGGTCACCCTACTGAAAATACTAAACCACCCTAACTAATGAGAAGATTCTATTCATTCCTTGAAGAG
TTTTTATAGAAAAGTTTAAGAAATGTAATTTGTTGCAATTAACATTTTTATGTTTTACATTTTACATTTTGATTATTGTGCAGAAACTGA
CAGAATTTAAAAAAATGGACTTCAGAAGTTCAAAATTTATCATTTTTGAAGAAGTTTATTTAGAATAGGATTTTATAACTAATTTGGACT
CTTCATCACATTGATGGATATAATACTTAGAATTATAAATTGCTAGATTTGATAAATACCTAACAAAATGTTTATTTTTTTCAGTCATAC
TTGACCACAAAACAAATATTTTACTAAATTTCCAGAGTCATTTCTCTGAAAAATAGTATAATGGCATGATAACATTTCACTAAATCCTAT
TTATCTTCTGGGAAATATTTTAATTTAGCTTTTGGATTTCCTAATATGATAAGCTTATATATTCATGGTATGAATTCCTTTAAAAAGAGC
ATCTGCTCTTGGACTTGTATCTGTTGCATCTTGTCAATGTTTGACTCATGGTCAGCATCCAATAGTTGTTAAATGAATAAATAAAATATA
ATACATTACCTATGTATCAAAAAGCATGTGTAAGAAAGCCAAATATGTTAACTGTTCTACTTTATTTATGTAATTATATTTTCATTAGTA
TTTTAGTAGATGGGGCTGTATAGAAAAACAAATGTATCATATGTAGCCAAATGAATCTTTTTCTTAAATGATATTATTATAGTAGGCTAC
AGTAATTTCAACAATTTTACAATAGAGTTTTGATCCTCTTCTTTGCGATTTGTTTCAGAGACACCTCATGAATCACACAAGAAAATTAGT
CTCAGTACTTATAGCCCTATTTCATTTTTCAATTCAGTTTTATCACACCATGGCTTCGAAGTGACTTTGATTGTGACCCCTAAGCAATTA
TCTGATTAGGGGATAAAAATTCATAATTCCAAGATGTTTCTGAAAATGTTCTGAACAATGACAACATATTTGGAATGAGGGCGTAATTTC
ACTAAGTGATGCTTCGAAGAACAATATTCATTTGGATATGCAAACACACATTTTCAAAAGTTATATTACTGTGTTACCATACCTGTTATA

>74077_74077_1_RICTOR-RANBP3L_RICTOR_chr5_39074213_ENST00000296782_RANBP3L_chr5_36271413_ENST00000296604_length(amino acids)=472AA_BP=37
MKPVNMAAIGRGRSLKNLRVRGRNDSGEENVPLDLTREKSVIAQPIFVFEKGEQTFKRPAEDTLYEAAEPECNGFPTKRVRSSSFTFHIT
DSQSQGVRKNNVFMTSALVQSSVDIKSAEQGPVKHSKHVIRPAILQLPQARSCAKVRKTFGHKALESCKTKEKTNNKISEGNSYLLSENL
SRARISVQLSTNQDFLGATSVGCQPNEDKCSFKSCSSNFVFGENMVERVLGTQKLTQPQLENDSYAKEKPFKSIPKFPVNFLSSRTDSIK
NTSLIESAAAFSSQPSRKCLLEKIDVITGEETEHNVLKINCKLFIFNKTTQSWIERGRGTLRLNDTASTDCGTLQSRLIMRNQGSLRLIL
NSKLWAQMKIQRANHKNVRITATDLEDYSIKIFLIQASAQDTAYLYAAIHHRLVALQSFNKQRDVNQAESLSETAQQLNCESCDENEDDF

--------------------------------------------------------------
>74077_74077_2_RICTOR-RANBP3L_RICTOR_chr5_39074213_ENST00000296782_RANBP3L_chr5_36271413_ENST00000502994_length(transcript)=1822nt_BP=119nt
GTTGTGACTGAAACCCGTCAATATGGCGGCGATCGGCCGCGGCCGCTCTCTGAAGAACCTCCGAGTACGAGGGCGGAATGACAGCGGCGA
GGAGAACGTCCCGCTGGATCTGACCCGAGAAAAATCTGTCATTGCTCAACCCATATTTGTTTTTGAAAAGGGAGAACAAACTTTTAAGAG
ACCTGCAGAAGACACCCTGTATGAAGCAGCAGAACCAGAATGTAATGGTTTTCCAACAAAGCGTGTACGGTCTTCATCTTTTACTTTTCA
TATTACAGATTCTCAGTCCCAGGGAGTGTCAACCTTGTCTCAGAAGCAAATGAGATGTTCATCCGTCACTAACCTCCCAACCTTCCCCCA
TTCTGGGCCAGTGAGGAAAAACAATGTTTTTATGACATCAGCTCTTGTGCAAAGTAGTGTTGATATAAAGAGTGCTGAACAAGGTCCTGT
GAAACATTCTAAACATGTTATTAGACCTGCTATTTTGCAGCTACCTCAAGCTCGAAGTTGTGCAAAAGTAAGAAAAACATTTGGACACAA
GGCACTGGAATCTTGCAAGACTAAAGAAAAAACAAATAATAAGATTTCTGAGGGAAATTCCTATTTGTTAAGTGAAAATTTATCAAGGGC
TAGAATTTCAGTCCAGCTGTCTACTAACCAGGACTTTTTAGGTGCAACATCAGTAGGATGTCAACCAAATGAAGATAAATGTTCTTTTAA
AAGCTGCAGTTCCAATTTTGTTTTTGGAGAAAACATGGTAGAAAGAGTTTTGGGTACTCAAAAACTCACCCAGCCTCAACTTGAAAATGA
TTCATATGCCAAGGAAAAACCATTCAAATCCATTCCGAAATTTCCTGTCAACTTTTTAAGTTCAAGAACAGACTCTATTAAAAATACTTC
CCTAATTGAATCAGCTGCTGCATTCTCTTCCCAACCATCACGAAAATGCTTGCTGGAGAAAATTGATGTTATAACAGGGGAGGAAACAGA
ACATAATGTGTTAAAGATAAACTGCAAGCTTTTCATATTCAACAAAACAACACAATCCTGGATTGAAAGGGGCAGAGGAACGTTGAGACT
GAATGACACAGCAAGCACTGACTGTGGAACATTACAGTCAAGACTAATTATGCGCAATCAAGGCAGTCTAAGGCTGATCCTCAACAGCAA
ACTCTGGGCCCAAATGAAGATTCAAAGAGCAAACCACAAAAATGTACGAATAACAGCTACTGATTTAGAAGACTATAGCATCAAAATATT
TTTAATTCAGGCCAGTGCCCAAGATACAGCATATTTGTATGCAGCAATACATCATCGTCTTGTTGCACTTCAAAGCTTCAATAAGCAGAG
AGATGTCAATCAAGCTGAAAGCCTGTCAGAAACAGCCCAACAATTGAACTGCGAAAGCTGTGATGAGAATGAGGATGATTTCATCCAAGT
CACTAAAAATGGATCAGATCCTTCTAGTTGGACTCACAGACAGTCGGTTGCCTGTTCATGAATACTACCTACTATAAACATGACATCTAC
AAAAAGAGGGGTCACCCTACTGAAAATACTAAACCACCCTAACTAATGAGAAGATTCTATTCATTCCTTGAAGAGTTTTTATAGAAAAGT
TTAAGAAATGTAATTTGTTGCAATTAACATTTTTATGTTTTACATTTTACATTTTGATTATTGTGCAGAAACTGACAGAATTTAAAAAAA
TGGACTTCAGAAGTTCAAAATTTATCATTTTTGAAGAAGTTTATTTAGAATAGGATTTTATAACTAATTTGGACTCTTCATCACATTGAT

>74077_74077_2_RICTOR-RANBP3L_RICTOR_chr5_39074213_ENST00000296782_RANBP3L_chr5_36271413_ENST00000502994_length(amino acids)=497AA_BP=37
MKPVNMAAIGRGRSLKNLRVRGRNDSGEENVPLDLTREKSVIAQPIFVFEKGEQTFKRPAEDTLYEAAEPECNGFPTKRVRSSSFTFHIT
DSQSQGVSTLSQKQMRCSSVTNLPTFPHSGPVRKNNVFMTSALVQSSVDIKSAEQGPVKHSKHVIRPAILQLPQARSCAKVRKTFGHKAL
ESCKTKEKTNNKISEGNSYLLSENLSRARISVQLSTNQDFLGATSVGCQPNEDKCSFKSCSSNFVFGENMVERVLGTQKLTQPQLENDSY
AKEKPFKSIPKFPVNFLSSRTDSIKNTSLIESAAAFSSQPSRKCLLEKIDVITGEETEHNVLKINCKLFIFNKTTQSWIERGRGTLRLND
TASTDCGTLQSRLIMRNQGSLRLILNSKLWAQMKIQRANHKNVRITATDLEDYSIKIFLIQASAQDTAYLYAAIHHRLVALQSFNKQRDV

--------------------------------------------------------------
>74077_74077_3_RICTOR-RANBP3L_RICTOR_chr5_39074213_ENST00000296782_RANBP3L_chr5_36271413_ENST00000515759_length(transcript)=1076nt_BP=119nt
GTTGTGACTGAAACCCGTCAATATGGCGGCGATCGGCCGCGGCCGCTCTCTGAAGAACCTCCGAGTACGAGGGCGGAATGACAGCGGCGA
GGAGAACGTCCCGCTGGATCTGACCCGAGAAAAATCTGTCATTGCTCAACCCATATTTGTTTTTGAAAAGGGAGAACAAACTTTTAAGAG
ACCTGCAGAAGACACCCTGTATGAAGCAGCAGAACCAGAATGTAATGGTTTTCCAACAAAGCGTGTACGGTCTTCATCTTTTACTTTTCA
TATTACAGATTCTCAGTCCCAGGGAGTGAGGAAAAACAATGTTTTTATGACATCAGCTCTTGTGCAAAGTAGTGTTGATATAAAGAGTGC
TGAACAAGGTCCTGTGAAACATTCTAAACATGTTATTAGACCTGCTATTTTGCAGCTACCTCAAGCTCGAAGTTGTGCAAAAGTAAGAAA
AACATTTGGACACAAGGCACTGGAATCTTGCAAGACTAAAGAAAAAACAAATAATAAGATTTCTGAGGGAAATTCCTATTTGTTAAGTGA
AAATTTATCAAGGGCTAGAATTTCAGTCCAGCTGTCTACTAACCAGGACTTTTTAGGTGCAACATCAGTAGGATGTCAACCAAATGAAGA
TAAATGTTCTTTTAAAAGCTGCAGTTCCAATTTTGTTTTTGGAGAAAACATGGTAGAAAGAGTTTTGGGTACTCAAAAACTCACCCAGCC
TCAACTTGAAAATGATTCATATGCCAAGGAAAAACCATTCAAATCCATTCCGAAATTTCCTGTCAACTTTTTAAGTTCAAGAACAGACTC
TATTAAAAATACTTCCCTAATTGAATCAGCTGCTGCATTCTCTTCCCAACCATCACGAAAATGCTTGCTGGAGAAAATTGATGTTATAAC
AGGGGAGGAAACAGAACATAATGTGTTAAAGGTCTGTATATCATGTTTTACTCTTTCTGGTAGCATTTACATACTTGGAATAAAGTTAAC

>74077_74077_3_RICTOR-RANBP3L_RICTOR_chr5_39074213_ENST00000296782_RANBP3L_chr5_36271413_ENST00000515759_length(amino acids)=328AA_BP=37
MKPVNMAAIGRGRSLKNLRVRGRNDSGEENVPLDLTREKSVIAQPIFVFEKGEQTFKRPAEDTLYEAAEPECNGFPTKRVRSSSFTFHIT
DSQSQGVRKNNVFMTSALVQSSVDIKSAEQGPVKHSKHVIRPAILQLPQARSCAKVRKTFGHKALESCKTKEKTNNKISEGNSYLLSENL
SRARISVQLSTNQDFLGATSVGCQPNEDKCSFKSCSSNFVFGENMVERVLGTQKLTQPQLENDSYAKEKPFKSIPKFPVNFLSSRTDSIK

--------------------------------------------------------------
>74077_74077_4_RICTOR-RANBP3L_RICTOR_chr5_39074213_ENST00000357387_RANBP3L_chr5_36271413_ENST00000296604_length(transcript)=2655nt_BP=128nt
GTTTCCGGTGTTGTGACTGAAACCCGTCAATATGGCGGCGATCGGCCGCGGCCGCTCTCTGAAGAACCTCCGAGTACGAGGGCGGAATGA
CAGCGGCGAGGAGAACGTCCCGCTGGATCTGACCCGAGAAAAATCTGTCATTGCTCAACCCATATTTGTTTTTGAAAAGGGAGAACAAAC
TTTTAAGAGACCTGCAGAAGACACCCTGTATGAAGCAGCAGAACCAGAATGTAATGGTTTTCCAACAAAGCGTGTACGGTCTTCATCTTT
TACTTTTCATATTACAGATTCTCAGTCCCAGGGAGTGAGGAAAAACAATGTTTTTATGACATCAGCTCTTGTGCAAAGTAGTGTTGATAT
AAAGAGTGCTGAACAAGGTCCTGTGAAACATTCTAAACATGTTATTAGACCTGCTATTTTGCAGCTACCTCAAGCTCGAAGTTGTGCAAA
AGTAAGAAAAACATTTGGACACAAGGCACTGGAATCTTGCAAGACTAAAGAAAAAACAAATAATAAGATTTCTGAGGGAAATTCCTATTT
GTTAAGTGAAAATTTATCAAGGGCTAGAATTTCAGTCCAGCTGTCTACTAACCAGGACTTTTTAGGTGCAACATCAGTAGGATGTCAACC
AAATGAAGATAAATGTTCTTTTAAAAGCTGCAGTTCCAATTTTGTTTTTGGAGAAAACATGGTAGAAAGAGTTTTGGGTACTCAAAAACT
CACCCAGCCTCAACTTGAAAATGATTCATATGCCAAGGAAAAACCATTCAAATCCATTCCGAAATTTCCTGTCAACTTTTTAAGTTCAAG
AACAGACTCTATTAAAAATACTTCCCTAATTGAATCAGCTGCTGCATTCTCTTCCCAACCATCACGAAAATGCTTGCTGGAGAAAATTGA
TGTTATAACAGGGGAGGAAACAGAACATAATGTGTTAAAGATAAACTGCAAGCTTTTCATATTCAACAAAACAACACAATCCTGGATTGA
AAGGGGCAGAGGAACGTTGAGACTGAATGACACAGCAAGCACTGACTGTGGAACATTACAGTCAAGACTAATTATGCGCAATCAAGGCAG
TCTAAGGCTGATCCTCAACAGCAAACTCTGGGCCCAAATGAAGATTCAAAGAGCAAACCACAAAAATGTACGAATAACAGCTACTGATTT
AGAAGACTATAGCATCAAAATATTTTTAATTCAGGCCAGTGCCCAAGATACAGCATATTTGTATGCAGCAATACATCATCGTCTTGTTGC
ACTTCAAAGCTTCAATAAGCAGAGAGATGTCAATCAAGCTGAAAGCCTGTCAGAAACAGCCCAACAATTGAACTGCGAAAGCTGTGATGA
GAATGAGGATGATTTCATCCAAGTCACTAAAAATGGATCAGATCCTTCTAGTTGGACTCACAGACAGTCGGTTGCCTGTTCATGAATACT
ACCTACTATAAACATGACATCTACAAAAAGAGGGGTCACCCTACTGAAAATACTAAACCACCCTAACTAATGAGAAGATTCTATTCATTC
CTTGAAGAGTTTTTATAGAAAAGTTTAAGAAATGTAATTTGTTGCAATTAACATTTTTATGTTTTACATTTTACATTTTGATTATTGTGC
AGAAACTGACAGAATTTAAAAAAATGGACTTCAGAAGTTCAAAATTTATCATTTTTGAAGAAGTTTATTTAGAATAGGATTTTATAACTA
ATTTGGACTCTTCATCACATTGATGGATATAATACTTAGAATTATAAATTGCTAGATTTGATAAATACCTAACAAAATGTTTATTTTTTT
CAGTCATACTTGACCACAAAACAAATATTTTACTAAATTTCCAGAGTCATTTCTCTGAAAAATAGTATAATGGCATGATAACATTTCACT
AAATCCTATTTATCTTCTGGGAAATATTTTAATTTAGCTTTTGGATTTCCTAATATGATAAGCTTATATATTCATGGTATGAATTCCTTT
AAAAAGAGCATCTGCTCTTGGACTTGTATCTGTTGCATCTTGTCAATGTTTGACTCATGGTCAGCATCCAATAGTTGTTAAATGAATAAA
TAAAATATAATACATTACCTATGTATCAAAAAGCATGTGTAAGAAAGCCAAATATGTTAACTGTTCTACTTTATTTATGTAATTATATTT
TCATTAGTATTTTAGTAGATGGGGCTGTATAGAAAAACAAATGTATCATATGTAGCCAAATGAATCTTTTTCTTAAATGATATTATTATA
GTAGGCTACAGTAATTTCAACAATTTTACAATAGAGTTTTGATCCTCTTCTTTGCGATTTGTTTCAGAGACACCTCATGAATCACACAAG
AAAATTAGTCTCAGTACTTATAGCCCTATTTCATTTTTCAATTCAGTTTTATCACACCATGGCTTCGAAGTGACTTTGATTGTGACCCCT
AAGCAATTATCTGATTAGGGGATAAAAATTCATAATTCCAAGATGTTTCTGAAAATGTTCTGAACAATGACAACATATTTGGAATGAGGG
CGTAATTTCACTAAGTGATGCTTCGAAGAACAATATTCATTTGGATATGCAAACACACATTTTCAAAAGTTATATTACTGTGTTACCATA

>74077_74077_4_RICTOR-RANBP3L_RICTOR_chr5_39074213_ENST00000357387_RANBP3L_chr5_36271413_ENST00000296604_length(amino acids)=472AA_BP=37
MKPVNMAAIGRGRSLKNLRVRGRNDSGEENVPLDLTREKSVIAQPIFVFEKGEQTFKRPAEDTLYEAAEPECNGFPTKRVRSSSFTFHIT
DSQSQGVRKNNVFMTSALVQSSVDIKSAEQGPVKHSKHVIRPAILQLPQARSCAKVRKTFGHKALESCKTKEKTNNKISEGNSYLLSENL
SRARISVQLSTNQDFLGATSVGCQPNEDKCSFKSCSSNFVFGENMVERVLGTQKLTQPQLENDSYAKEKPFKSIPKFPVNFLSSRTDSIK
NTSLIESAAAFSSQPSRKCLLEKIDVITGEETEHNVLKINCKLFIFNKTTQSWIERGRGTLRLNDTASTDCGTLQSRLIMRNQGSLRLIL
NSKLWAQMKIQRANHKNVRITATDLEDYSIKIFLIQASAQDTAYLYAAIHHRLVALQSFNKQRDVNQAESLSETAQQLNCESCDENEDDF

--------------------------------------------------------------
>74077_74077_5_RICTOR-RANBP3L_RICTOR_chr5_39074213_ENST00000357387_RANBP3L_chr5_36271413_ENST00000502994_length(transcript)=1831nt_BP=128nt
GTTTCCGGTGTTGTGACTGAAACCCGTCAATATGGCGGCGATCGGCCGCGGCCGCTCTCTGAAGAACCTCCGAGTACGAGGGCGGAATGA
CAGCGGCGAGGAGAACGTCCCGCTGGATCTGACCCGAGAAAAATCTGTCATTGCTCAACCCATATTTGTTTTTGAAAAGGGAGAACAAAC
TTTTAAGAGACCTGCAGAAGACACCCTGTATGAAGCAGCAGAACCAGAATGTAATGGTTTTCCAACAAAGCGTGTACGGTCTTCATCTTT
TACTTTTCATATTACAGATTCTCAGTCCCAGGGAGTGTCAACCTTGTCTCAGAAGCAAATGAGATGTTCATCCGTCACTAACCTCCCAAC
CTTCCCCCATTCTGGGCCAGTGAGGAAAAACAATGTTTTTATGACATCAGCTCTTGTGCAAAGTAGTGTTGATATAAAGAGTGCTGAACA
AGGTCCTGTGAAACATTCTAAACATGTTATTAGACCTGCTATTTTGCAGCTACCTCAAGCTCGAAGTTGTGCAAAAGTAAGAAAAACATT
TGGACACAAGGCACTGGAATCTTGCAAGACTAAAGAAAAAACAAATAATAAGATTTCTGAGGGAAATTCCTATTTGTTAAGTGAAAATTT
ATCAAGGGCTAGAATTTCAGTCCAGCTGTCTACTAACCAGGACTTTTTAGGTGCAACATCAGTAGGATGTCAACCAAATGAAGATAAATG
TTCTTTTAAAAGCTGCAGTTCCAATTTTGTTTTTGGAGAAAACATGGTAGAAAGAGTTTTGGGTACTCAAAAACTCACCCAGCCTCAACT
TGAAAATGATTCATATGCCAAGGAAAAACCATTCAAATCCATTCCGAAATTTCCTGTCAACTTTTTAAGTTCAAGAACAGACTCTATTAA
AAATACTTCCCTAATTGAATCAGCTGCTGCATTCTCTTCCCAACCATCACGAAAATGCTTGCTGGAGAAAATTGATGTTATAACAGGGGA
GGAAACAGAACATAATGTGTTAAAGATAAACTGCAAGCTTTTCATATTCAACAAAACAACACAATCCTGGATTGAAAGGGGCAGAGGAAC
GTTGAGACTGAATGACACAGCAAGCACTGACTGTGGAACATTACAGTCAAGACTAATTATGCGCAATCAAGGCAGTCTAAGGCTGATCCT
CAACAGCAAACTCTGGGCCCAAATGAAGATTCAAAGAGCAAACCACAAAAATGTACGAATAACAGCTACTGATTTAGAAGACTATAGCAT
CAAAATATTTTTAATTCAGGCCAGTGCCCAAGATACAGCATATTTGTATGCAGCAATACATCATCGTCTTGTTGCACTTCAAAGCTTCAA
TAAGCAGAGAGATGTCAATCAAGCTGAAAGCCTGTCAGAAACAGCCCAACAATTGAACTGCGAAAGCTGTGATGAGAATGAGGATGATTT
CATCCAAGTCACTAAAAATGGATCAGATCCTTCTAGTTGGACTCACAGACAGTCGGTTGCCTGTTCATGAATACTACCTACTATAAACAT
GACATCTACAAAAAGAGGGGTCACCCTACTGAAAATACTAAACCACCCTAACTAATGAGAAGATTCTATTCATTCCTTGAAGAGTTTTTA
TAGAAAAGTTTAAGAAATGTAATTTGTTGCAATTAACATTTTTATGTTTTACATTTTACATTTTGATTATTGTGCAGAAACTGACAGAAT
TTAAAAAAATGGACTTCAGAAGTTCAAAATTTATCATTTTTGAAGAAGTTTATTTAGAATAGGATTTTATAACTAATTTGGACTCTTCAT

>74077_74077_5_RICTOR-RANBP3L_RICTOR_chr5_39074213_ENST00000357387_RANBP3L_chr5_36271413_ENST00000502994_length(amino acids)=497AA_BP=37
MKPVNMAAIGRGRSLKNLRVRGRNDSGEENVPLDLTREKSVIAQPIFVFEKGEQTFKRPAEDTLYEAAEPECNGFPTKRVRSSSFTFHIT
DSQSQGVSTLSQKQMRCSSVTNLPTFPHSGPVRKNNVFMTSALVQSSVDIKSAEQGPVKHSKHVIRPAILQLPQARSCAKVRKTFGHKAL
ESCKTKEKTNNKISEGNSYLLSENLSRARISVQLSTNQDFLGATSVGCQPNEDKCSFKSCSSNFVFGENMVERVLGTQKLTQPQLENDSY
AKEKPFKSIPKFPVNFLSSRTDSIKNTSLIESAAAFSSQPSRKCLLEKIDVITGEETEHNVLKINCKLFIFNKTTQSWIERGRGTLRLND
TASTDCGTLQSRLIMRNQGSLRLILNSKLWAQMKIQRANHKNVRITATDLEDYSIKIFLIQASAQDTAYLYAAIHHRLVALQSFNKQRDV

--------------------------------------------------------------
>74077_74077_6_RICTOR-RANBP3L_RICTOR_chr5_39074213_ENST00000357387_RANBP3L_chr5_36271413_ENST00000515759_length(transcript)=1085nt_BP=128nt
GTTTCCGGTGTTGTGACTGAAACCCGTCAATATGGCGGCGATCGGCCGCGGCCGCTCTCTGAAGAACCTCCGAGTACGAGGGCGGAATGA
CAGCGGCGAGGAGAACGTCCCGCTGGATCTGACCCGAGAAAAATCTGTCATTGCTCAACCCATATTTGTTTTTGAAAAGGGAGAACAAAC
TTTTAAGAGACCTGCAGAAGACACCCTGTATGAAGCAGCAGAACCAGAATGTAATGGTTTTCCAACAAAGCGTGTACGGTCTTCATCTTT
TACTTTTCATATTACAGATTCTCAGTCCCAGGGAGTGAGGAAAAACAATGTTTTTATGACATCAGCTCTTGTGCAAAGTAGTGTTGATAT
AAAGAGTGCTGAACAAGGTCCTGTGAAACATTCTAAACATGTTATTAGACCTGCTATTTTGCAGCTACCTCAAGCTCGAAGTTGTGCAAA
AGTAAGAAAAACATTTGGACACAAGGCACTGGAATCTTGCAAGACTAAAGAAAAAACAAATAATAAGATTTCTGAGGGAAATTCCTATTT
GTTAAGTGAAAATTTATCAAGGGCTAGAATTTCAGTCCAGCTGTCTACTAACCAGGACTTTTTAGGTGCAACATCAGTAGGATGTCAACC
AAATGAAGATAAATGTTCTTTTAAAAGCTGCAGTTCCAATTTTGTTTTTGGAGAAAACATGGTAGAAAGAGTTTTGGGTACTCAAAAACT
CACCCAGCCTCAACTTGAAAATGATTCATATGCCAAGGAAAAACCATTCAAATCCATTCCGAAATTTCCTGTCAACTTTTTAAGTTCAAG
AACAGACTCTATTAAAAATACTTCCCTAATTGAATCAGCTGCTGCATTCTCTTCCCAACCATCACGAAAATGCTTGCTGGAGAAAATTGA
TGTTATAACAGGGGAGGAAACAGAACATAATGTGTTAAAGGTCTGTATATCATGTTTTACTCTTTCTGGTAGCATTTACATACTTGGAAT
AAAGTTAACATGAGAAGAGGCATCTTTAAAAATACAGACAGAAGTATAGTTTTCATGGAGACTAAGTTGCTTAAATAAAAATGTTGGATG

>74077_74077_6_RICTOR-RANBP3L_RICTOR_chr5_39074213_ENST00000357387_RANBP3L_chr5_36271413_ENST00000515759_length(amino acids)=328AA_BP=37
MKPVNMAAIGRGRSLKNLRVRGRNDSGEENVPLDLTREKSVIAQPIFVFEKGEQTFKRPAEDTLYEAAEPECNGFPTKRVRSSSFTFHIT
DSQSQGVRKNNVFMTSALVQSSVDIKSAEQGPVKHSKHVIRPAILQLPQARSCAKVRKTFGHKALESCKTKEKTNNKISEGNSYLLSENL
SRARISVQLSTNQDFLGATSVGCQPNEDKCSFKSCSSNFVFGENMVERVLGTQKLTQPQLENDSYAKEKPFKSIPKFPVNFLSSRTDSIK

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for RICTOR-RANBP3L

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	RICTOR	chr5:39074213	chr5:36271413	ENST00000296782	-	2	39	1_789	32.333333333333336	1733.0	NBN
Hgene	RICTOR	chr5:39074213	chr5:36271413	ENST00000357387	-	2	38	1_789	32.333333333333336	1709.0	NBN

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for RICTOR-RANBP3L

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for RICTOR-RANBP3L

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source