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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RIF1-PDE11A (FusionGDB2 ID:74084)

Fusion Gene Summary for RIF1-PDE11A

check button Fusion gene summary
Fusion gene informationFusion gene name: RIF1-PDE11A
Fusion gene ID: 74084
HgeneTgene
Gene symbol

RIF1

PDE11A

Gene ID

55791

50940

Gene nameligand dependent nuclear receptor interacting factor 1phosphodiesterase 11A
SynonymsC1orf103|HBiX1|RIF1PPNAD2
Cytomap

1p13.3

2q31.2

Type of geneprotein-codingprotein-coding
Descriptionligand-dependent nuclear receptor-interacting factor 1HP1-binding protein enriched in inactive X chromosome protein 1receptor-interacting factor 1dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11AcAMP and cGMP cyclic nucleotide phosphodiesterase 11A
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000243326, ENST00000428287, 
ENST00000430328, ENST00000444746, 
ENST00000453091, ENST00000433166, 
ENST00000457745, 		ENST00000497003, 
ENST00000389683, ENST00000409504, 
ENST00000449286, ENST00000450799, 
ENST00000286063, ENST00000358450, 
Fusion gene scores* DoF score6 X 6 X 4=1448 X 5 X 6=240
# samples 611
** MAII scorelog2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/240*10)=-1.12553088208386
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RIF1 [Title/Abstract] AND PDE11A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRIF1(152318980)-PDE11A(178592900), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across RIF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PDE11A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-AJ-A3NF-01ARIF1chr2

152318980

-PDE11Achr2

178592900

-
ChimerDB4UCECTCGA-AJ-A3NF-01ARIF1chr2

152318980

+PDE11Achr2

178592900

-


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Fusion Gene ORF analysis for RIF1-PDE11A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000243326ENST00000497003RIF1chr2

152318980

+PDE11Achr2

178592900

-
5CDS-5UTRENST00000428287ENST00000497003RIF1chr2

152318980

+PDE11Achr2

178592900

-
5CDS-5UTRENST00000430328ENST00000497003RIF1chr2

152318980

+PDE11Achr2

178592900

-
5CDS-5UTRENST00000444746ENST00000497003RIF1chr2

152318980

+PDE11Achr2

178592900

-
5CDS-5UTRENST00000453091ENST00000497003RIF1chr2

152318980

+PDE11Achr2

178592900

-
5CDS-intronENST00000243326ENST00000389683RIF1chr2

152318980

+PDE11Achr2

178592900

-
5CDS-intronENST00000243326ENST00000409504RIF1chr2

152318980

+PDE11Achr2

178592900

-
5CDS-intronENST00000243326ENST00000449286RIF1chr2

152318980

+PDE11Achr2

178592900

-
5CDS-intronENST00000243326ENST00000450799RIF1chr2

152318980

+PDE11Achr2

178592900

-
5CDS-intronENST00000428287ENST00000389683RIF1chr2

152318980

+PDE11Achr2

178592900

-
5CDS-intronENST00000428287ENST00000409504RIF1chr2

152318980

+PDE11Achr2

178592900

-
5CDS-intronENST00000428287ENST00000449286RIF1chr2

152318980

+PDE11Achr2

178592900

-
5CDS-intronENST00000428287ENST00000450799RIF1chr2

152318980

+PDE11Achr2

178592900

-
5CDS-intronENST00000430328ENST00000389683RIF1chr2

152318980

+PDE11Achr2

178592900

-
5CDS-intronENST00000430328ENST00000409504RIF1chr2

152318980

+PDE11Achr2

178592900

-
5CDS-intronENST00000430328ENST00000449286RIF1chr2

152318980

+PDE11Achr2

178592900

-
5CDS-intronENST00000430328ENST00000450799RIF1chr2

152318980

+PDE11Achr2

178592900

-
5CDS-intronENST00000444746ENST00000389683RIF1chr2

152318980

+PDE11Achr2

178592900

-
5CDS-intronENST00000444746ENST00000409504RIF1chr2

152318980

+PDE11Achr2

178592900

-
5CDS-intronENST00000444746ENST00000449286RIF1chr2

152318980

+PDE11Achr2

178592900

-
5CDS-intronENST00000444746ENST00000450799RIF1chr2

152318980

+PDE11Achr2

178592900

-
5CDS-intronENST00000453091ENST00000389683RIF1chr2

152318980

+PDE11Achr2

178592900

-
5CDS-intronENST00000453091ENST00000409504RIF1chr2

152318980

+PDE11Achr2

178592900

-
5CDS-intronENST00000453091ENST00000449286RIF1chr2

152318980

+PDE11Achr2

178592900

-
5CDS-intronENST00000453091ENST00000450799RIF1chr2

152318980

+PDE11Achr2

178592900

-
In-frameENST00000243326ENST00000286063RIF1chr2

152318980

+PDE11Achr2

178592900

-
In-frameENST00000243326ENST00000358450RIF1chr2

152318980

+PDE11Achr2

178592900

-
In-frameENST00000428287ENST00000286063RIF1chr2

152318980

+PDE11Achr2

178592900

-
In-frameENST00000428287ENST00000358450RIF1chr2

152318980

+PDE11Achr2

178592900

-
In-frameENST00000430328ENST00000286063RIF1chr2

152318980

+PDE11Achr2

178592900

-
In-frameENST00000430328ENST00000358450RIF1chr2

152318980

+PDE11Achr2

178592900

-
In-frameENST00000444746ENST00000286063RIF1chr2

152318980

+PDE11Achr2

178592900

-
In-frameENST00000444746ENST00000358450RIF1chr2

152318980

+PDE11Achr2

178592900

-
In-frameENST00000453091ENST00000286063RIF1chr2

152318980

+PDE11Achr2

178592900

-
In-frameENST00000453091ENST00000358450RIF1chr2

152318980

+PDE11Achr2

178592900

-
intron-3CDSENST00000433166ENST00000286063RIF1chr2

152318980

+PDE11Achr2

178592900

-
intron-3CDSENST00000433166ENST00000358450RIF1chr2

152318980

+PDE11Achr2

178592900

-
intron-3CDSENST00000457745ENST00000286063RIF1chr2

152318980

+PDE11Achr2

178592900

-
intron-3CDSENST00000457745ENST00000358450RIF1chr2

152318980

+PDE11Achr2

178592900

-
intron-5UTRENST00000433166ENST00000497003RIF1chr2

152318980

+PDE11Achr2

178592900

-
intron-5UTRENST00000457745ENST00000497003RIF1chr2

152318980

+PDE11Achr2

178592900

-
intron-intronENST00000433166ENST00000389683RIF1chr2

152318980

+PDE11Achr2

178592900

-
intron-intronENST00000433166ENST00000409504RIF1chr2

152318980

+PDE11Achr2

178592900

-
intron-intronENST00000433166ENST00000449286RIF1chr2

152318980

+PDE11Achr2

178592900

-
intron-intronENST00000433166ENST00000450799RIF1chr2

152318980

+PDE11Achr2

178592900

-
intron-intronENST00000457745ENST00000389683RIF1chr2

152318980

+PDE11Achr2

178592900

-
intron-intronENST00000457745ENST00000409504RIF1chr2

152318980

+PDE11Achr2

178592900

-
intron-intronENST00000457745ENST00000449286RIF1chr2

152318980

+PDE11Achr2

178592900

-
intron-intronENST00000457745ENST00000450799RIF1chr2

152318980

+PDE11Achr2

178592900

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000444746RIF1chr2152318980+ENST00000286063PDE11Achr2178592900-10693352410145371478
ENST00000444746RIF1chr2152318980+ENST00000358450PDE11Achr2178592900-5876352410145371478
ENST00000453091RIF1chr2152318980+ENST00000286063PDE11Achr2178592900-10693352410145371478
ENST00000453091RIF1chr2152318980+ENST00000358450PDE11Achr2178592900-5876352410145371478
ENST00000428287RIF1chr2152318980+ENST00000286063PDE11Achr2178592900-105963427444401478
ENST00000428287RIF1chr2152318980+ENST00000358450PDE11Achr2178592900-57793427444401478
ENST00000243326RIF1chr2152318980+ENST00000286063PDE11Achr2178592900-11015384640848591483
ENST00000243326RIF1chr2152318980+ENST00000358450PDE11Achr2178592900-6198384640848591483
ENST00000430328RIF1chr2152318980+ENST00000286063PDE11Achr2178592900-10866369725947101483
ENST00000430328RIF1chr2152318980+ENST00000358450PDE11Achr2178592900-6049369725947101483

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000444746ENST00000286063RIF1chr2152318980+PDE11Achr2178592900-0.0001117080.9998883
ENST00000444746ENST00000358450RIF1chr2152318980+PDE11Achr2178592900-0.00017450.99982554
ENST00000453091ENST00000286063RIF1chr2152318980+PDE11Achr2178592900-0.0001117080.9998883
ENST00000453091ENST00000358450RIF1chr2152318980+PDE11Achr2178592900-0.00017450.99982554
ENST00000428287ENST00000286063RIF1chr2152318980+PDE11Achr2178592900-9.96E-050.99990034
ENST00000428287ENST00000358450RIF1chr2152318980+PDE11Achr2178592900-0.0001539340.9998461
ENST00000243326ENST00000286063RIF1chr2152318980+PDE11Achr2178592900-0.0001441590.9998559
ENST00000243326ENST00000358450RIF1chr2152318980+PDE11Achr2178592900-0.0001983240.9998017
ENST00000430328ENST00000286063RIF1chr2152318980+PDE11Achr2178592900-0.0001217980.99987817
ENST00000430328ENST00000358450RIF1chr2152318980+PDE11Achr2178592900-0.0001675920.9998324

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Fusion Genomic Features for RIF1-PDE11A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RIF1-PDE11A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:152318980/chr2:178592900)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePDE11Achr2:152318980chr2:178592900ENST000003584501021402_558346684.0DomainNote=GAF 2
TgenePDE11Achr2:152318980chr2:178592900ENST000003584501021588_912346684.0DomainPDEase
TgenePDE11Achr2:152318980chr2:178592900ENST00000389683617217_370152490.0DomainNote=GAF 1
TgenePDE11Achr2:152318980chr2:178592900ENST00000389683617402_558152490.0DomainNote=GAF 2
TgenePDE11Achr2:152318980chr2:178592900ENST00000389683617588_912152490.0DomainPDEase
TgenePDE11Achr2:152318980chr2:178592900ENST00000409504820402_558238663.0DomainNote=GAF 2
TgenePDE11Achr2:152318980chr2:178592900ENST00000409504820588_912238663.0DomainPDEase
TgenePDE11Achr2:152318980chr2:178592900ENST00000449286819402_558238576.0DomainNote=GAF 2
TgenePDE11Achr2:152318980chr2:178592900ENST00000449286819588_912238576.0DomainPDEase

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePDE11Achr2:152318980chr2:178592900ENST00000286063920217_370596934.0DomainNote=GAF 1
TgenePDE11Achr2:152318980chr2:178592900ENST00000286063920402_558596934.0DomainNote=GAF 2
TgenePDE11Achr2:152318980chr2:178592900ENST00000286063920588_912596934.0DomainPDEase
TgenePDE11Achr2:152318980chr2:178592900ENST000003584501021217_370346684.0DomainNote=GAF 1
TgenePDE11Achr2:152318980chr2:178592900ENST00000409504820217_370238663.0DomainNote=GAF 1
TgenePDE11Achr2:152318980chr2:178592900ENST00000449286819217_370238576.0DomainNote=GAF 1


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Fusion Gene Sequence for RIF1-PDE11A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>74084_74084_1_RIF1-PDE11A_RIF1_chr2_152318980_ENST00000243326_PDE11A_chr2_178592900_ENST00000286063_length(transcript)=11015nt_BP=3846nt
TGAGTAAACAGCCGGAGCTGGGAAAGTCGAGCTCTGGCAGCGTCTGGGTGCTGAGGGGCAGAGGCGGAGAGAACCCTGTCCTGATCTTCC
TAGGTGGGATAAATATCGGGGTGACAGTGGTAGGCCGCGGGGAACCCTCAGTCTGCCCACCCTCCGCCCCCTCGCGGCGAGATGCCTCGT
TCCCCGGGCTTCTCCCGCCCTCCGCCGATCTCCTCCCTCTGTTGAAAGCTGCCCGGGAAAGTGGTGGCGGGAGCGGGCCCAGGCCCGAAT
GTGGCGTGGGCTCAGGTGTCTGGTGTCGGGCGCCGGAGGAGGTTCGCGCTGGGGTTTGGTGATTCGGAGGCCTGGGGTGCAGACGCGGCG
TGGCTGTGAGGCCCGGGCGGGCGTGCGGGTGTGAGGGCCGGACTCACACTGGGCCGCCGCGGGGCTGTTTCCATCGGTCACTGGATTTTC
TCCTCTTCCGGTTCGGGCCTCAGGGTGGCCGACATGACGGCCAGGGGTCAGAGCCCCCTCGCGCCGCTGTTGGAGACTTTGGAAGACCCT
TCTGCCTCCCATGGAGGGCAGACTGACGCTTACCTGACTCTGACCAGTCGTATGACTGGAGAAGAAGGAAAAGAAGTAATTACAGAAATT
GAGAAAAAACTTCCTCGGCTGTACAAAGTTTTAAAGACTCACATTTCCAGTCAAAACTCGGAGCTGAGTAGTGCTGCTCTACAAGCCCTG
GGGTTTTGCTTATATAATCCCAAAATTACCTCAGAATTATCAGAGGCAAATGCTCTAGAATTGCTTTCAAAATTGAATGATACCATTAAG
AATTCAGACAAAAATGTACGTACTAGAGCACTTTGGGTGATATCTAAGCAGACATTTCCCTCTGAAGTGGTTGGCAAAATGGTATCCAGT
ATAATTGATTCATTAGAAATACTGTTTAACAAAGGAGAGACGCATTCTGCTGTTGTTGATTTTGAAGCATTAAATGTTATCGTAAGGCTA
ATTGAACAAGCCCCAATTCAAATGGGAGAAGAGGCAGTGAGGTGGGCAAAACTGGTCATACCTTTAGTGGTTCATTCAGCACAAAAGGTA
CATTTGCGGGGAGCAACTGCTCTGGAGATGGGAATGCCATTATTGCTTCAGAAACAGCAAGAAATAGCATCTATTACGGAGCAGCTTATG
ACTACTAAATTAATCTCAGAACTTCAGAAGCTATTTATGAGTAAAAATGAGACTTACGTGTTAAAATTATGGCCTTTGTTTGTCAAACTA
CTTGGAAGGACCTTGCATCGAAGTGGGAGTTTCATCAATTCTCTCTTGCAACTAGAAGAACTTGGATTTCGTAGTGGAGCACCCATGATT
AAAAAGATAGCTTTTATTGCTTGGAAGAGTTTAATAGATAATTTTGCTTTAAATCCAGATATACTATGTAGTGCAAAAAGACTCAAGTTG
TTAATGCAGCCTTTGAGTTCCATCCATGTGAGAACAGAAACTCTAGCATTAACAAAACTAGAAGTCTGGTGGTATTTACTGATGAGACTT
GGACCTCATCTTCCTGCTAATTTTGAACAGGTTTGTGTGCCTCTGATTCAAAGTACAATAAGCATTGATTCTAATGCCTCACCTCAGGGC
AATTCGTGTCATGTAGCTACATCTCCAGGTTTAAATCCTATGACTCCTGTACACAAAGGTGCTTCCTCCCCGTACGGAGCCCCGGGAACT
CCCCGAATGAACCTGAGTTCGAATTTAGGTGGAATGGCCACAATCCCATCCATTCAACTTTTGGGACTTGAAATGTTGCTTCATTTCTTG
TTGGGTCCAGAAGCCTTGAGTTTTGCTAAGCAAAATAAACTTGTGCTGAGCTTAGAGCCATTGGAACATCCGTTAATCAGCAGCCCTTCC
TTTTTTTCCAAACATGCAAATACACTTATCACTGCTGTTCATGATAGCTTTGTTGCAGTTGGAAAAGATGCCCCCGATGTGGTTGTCAGT
GCTATCTGGAAGGAGCTAATTAGCTTGGTGAAGTCAGTTACTGAATCAGGTAACAAAAAAGAGAAACCAGGTTCTGAAGTTTTGACTCTC
TTATTAAAGTCTTTGGAAAGCATAGTAAAGTCTGAAGTATTTCCTGTATCAAAAACGCTGGTCCTCATGGAAATTACAATTAAAGGACTT
CCTCAGAAAGTATTAGGTTCACCAGCATATCAGGTTGCTAATATGGATATTCTTAATGGAACTCCAGCTTTGTTCTTAATTCAATTAATT
TTCAACAATTTCTTGGAATGTGGTGTATCAGATGAAAGGTTCTTTCTCAGTTTGGAATCACTTGTAGGCTGTGTTCTTTCTGGTCCAACT
TCACCACTAGCTTTCAGTGACTCAGTTTTAAATGTTATTAATCAAAATGCAAAGCAGTTGGAAAATAAGGAGCATCTCTGGAAAATGTGG
AGTGTTATAGTCACCCCATTAACTGAATTGATTAATCAGACCAATGAAGTAAATCAAGGTGATGCCTTAGAACATAATTTTAGTGCCATC
TATGGTGCATTGACTTTACCAGTAAACCACATTTTTTCAGAACAGAGATTTCCAGTGGCCACCATGAAGACTTTGCTTAGAACTTGGTCA
GAATTATATAGAGCATTTGCTCGTTGTGCTGCTTTGGTGGCAACAGCAGAAGAGAACTTGTGCTGTGAGGAACTTTCTTCCAAGATAATG
TCCAGTTTGGAAGATGAAGGCTTTTCTAATTTGTTGTTCGTGGATAGAATTATTTATATTATTACTGTAATGGTTGATTGCATTGACTTC
TCACCATATAATATTAAATATCAGCCCAAAGTTAAATCACCACAGAGACCTTCAGATTGGTCCAAAAAGAAGAATGAGCCCCTAGGGAAA
TTGACTTCTTTATTTAAACTTATTGTGAAAGTGATCTATTCTTTCCACACACTGAGCTTCAAGGAAGCACATTCTGATACCCTCTTCACT
ATTGGCAACTCAATCACCGGCATTATTTCCAGTGTACTTGGGCATATTTCTTTGCCTTCTATGATCCGAAAAATATTTGCAACTTTAACA
AGACCTCTGGCATTATTTTATGAAAACTCAAAGCTTGATGAAGTTCCTAAAGTATATAGTTGTCTGAACAACAAGTTAGAAAAGCTACTG
GGAGAAATTATTGCTTGTCTGCAATTCAGCTACACCGGAACTTATGATAGTGAACTTCTTGAACAACTCTCCCCACTATTATGCATAATA
TTTCTGCACAAGAATAAACAGATTCGAAAACAGAGTGCTCAGTTCTGGAATGCCACTTTTGCCAAAGTGATGATGTTGGTTTATCCTGAA
GAGTTAAAACCAGTACTAACACAAGCCAAACAAAAATTTCTGCTCCTGTTGCCTGGTTTGGAAACTGTTGAAATGATGGAGGAATCCAGT
GGACCATATTCTGATGGAACAGAAAATTCACAACTAAATGTGAAGATAAGTGGCATGGAGAGAAAATCAAATGGAAAAAGAGATTCATTT
TTGGCACAAACAAAGAATAAAAAAGAAAATATGAAACCAGCAGCCAAACTGAAACTTGAATCTTCGTCTTTAAAAGTAAAGGGTGAAATT
CTTTTGGAAGAGGAAAAGTCTACTGACTTTGTGTTTATACCTCCAGAAGGAAAAGATGCAAAGGAAAGAATATTAACTGATCATCAAAAA
GAAGTTCTCAAAACAAAGCGGTGTGATATTCCTGCCATGTATAATAATCTGGATGTTTCCCAAGATACCTTATTTACTCAGTATAGTCAG
GAAGAGCCTATGGAAATTCCTACTTTAACCAGAAAACCAAAGGAGGATTCTAAGATGATGATTACGGCAGCCAACATCCCTCTGGTGTCA
GAACTTGCCATCGATGACATTCATTTTGATGACTTTTCTCTCGACGTTGATGCCATGATCACAGCTGCTCTCCGGATGTTCATGGAGCTG
GGGATGGTACAGAAATTTAAAATTGACTATGAGACACTGTGTAGGTGGCTTTTGACAGTGAGGAAAAACTATCGGATGGTTCTATACCAC
AACTGGAGACATGCCTTCAACGTGTGTCAGCTGATGTTCGCGATGTTAACCACTGCTGGGTTTCAAGACATTCTGACCGAGGTGGAAATT
TTAGCGGTGATTGTGGGATGCCTGTGTCATGACCTCGACCACAGGGGAACCAACAATGCCTTCCAAGCTAAGAGTGGCTCTGCCCTGGCC
CAACTCTATGGAACCTCTGCTACCTTGGAGCATCACCATTTCAACCACGCCGTGATGATCCTTCAAAGTGAGGGTCACAATATCTTTGCT
AACCTGTCCTCCAAGGAATATAGTGACCTTATGCAGCTTTTGAAGCAGTCAATATTGGCAACAGACCTCACGCTGTACTTTGAGAGGAGA
ACTGAATTCTTTGAACTTGTCAGTAAAGGAGAATACGATTGGAACATCAAAAACCATCGTGATATATTTCGATCAATGTTAATGACAGCC
TGTGACCTTGGAGCCGTGACCAAACCGTGGGAGATCTCCAGACAGGTGGCAGAACTTGTAACCAGTGAGTTCTTCGAACAAGGAGATCGG
GAGAGATTAGAGCTCAAACTCACTCCTTCAGCAATTTTTGATCGGAACCGGAAGGATGAACTGCCTCGGTTGCAACTGGAGTGGATTGAT
AGCATCTGCATGCCTTTGTATCAGGCACTGGTGAAGGTCAACGTGAAACTGAAGCCGATGCTAGATTCAGTAGCTACAAACAGAAGTAAG
TGGGAAGAGCTACACCAAAAACGACTGCTGGCCTCAACTGCCTCATCCTCCCCTGCCAGTGTTATGGTAGCCAAGGAAGACAGGAACTAA
ACCTCCAGGTCAGCTGCAGCTGCAAAATGACTACAGCCTGAAGGGCCATTTTCAGTCCAGCAATGTCATCCTTTTGTTCTTTTAGCTCAG
AAAGACCTAACATCTCAAGGATGCACTGGGAAGCATGCCTGGGCTTTCACCTTGAAGCATGGTCAGCAGCAGAGAGAGCAACGGGAAGGA
CAAAGAAAGAGGTGGGGCAGGGAGCACACCCCAGGACCCTCACTTTTCCCTAATGAACACGCATGGGCTGAAATGAAGGCTCTGGGTAGG
GGACTGTTTTGGATCCAAGGACCTGTGGACAGTCGGCCTACTTACTCTGAGCTGAGGGAACACTGAACAGTAAAAGCGTCATTAGCGCTG
CTTCGTTTTGTATAGGGCTTTTCTGTTTGTTACAAGCCAAACACTGCCTGTCTTTGCTTCCTGTCCCTGAATGCCTTTTTGTGCCAGACT
GTCCCAAGAATCCTAATTTGTATTCCATAGAGGTATTTTATTTTTAATCCTAGAGCTTCTTATTGATGGATCCTTTAGAATTGCCTACCT
AAAAGGTAAACTATACTATCCTTATAAATACTGATCAATCCCAGTTCTCCCCCTAAAAATGAATACATAGTAGGACTATAGCAAATGTGT
TTGATGGGTAATTCTAGACTGGGACTATGGTACCCTTTTCCAGAGTTTTAAAATTCAACCTTCATTACAGACAAAGTTTTCTCCCAGAAG
GAATGGATTGATAGATTTTGATTAAAGTAAGGGTGGAAGGAAATCTGTAGCTGGATTTACCACAAGTGACATCTAGAAACTATAGTTCAC
AGGACAGAGCAGAGCCATGGAGACTAAGCATTGACTACCTTGAGTTCTCCTAGTGAGGAGTTCTGGTATAAAATTTAAGATTACTACCAG
TAACCAACTTAAAGCAAACTATAGGGGTCCCTAATTTTGGATTTTTCCTTAAGTGTAAGAAACAATGCTTCAAATGTTAAGAAATAACAG
TCTGGGCAAAGAACGCATATTCTATAGGAAGCCAGGTTTACAATAGGTAAGAATAAACTGTATTAAGTAGATGTAATGACTAGAAAGCTG
CTTTGCTCCCTATATTGAGAAATTGTGGACATGGTATGTGTTATCCAAAGAACATTGGGCTAGAAGATAGATTTCTATCCTTAGCTTTGG
CATTATTGACTGGATTGACTTGAACAAGTCACTTAACTTCTACAAGCTTGTTTCCTTATTTGTCAAATTAGATTACACTAGGAAACGATT
CTCGAACATGTTTTAACCTTACAACTCTTTGTTCAAATAAATCTTTCAATGAATCCCCAACATATAAAACGTCAAAAAGCTGAATTCCTA
TGTGAATTATAAGCAGGGTTTGGACATCCAGAGCACCTACAAACCTTCATCTCTTTGATTACGTACATGGGGGTCCACAGGGACTCTGAA
GAGTTTGAAAATCCCTGGCCTAGATTAAACCTGAGAGCCATTCTAGCTCTTAAAAAAATCTGAAATTTACAAACCATTTTTCTTGTTATT
GTTTTTGTTTCTTTGTTTGTTTGTTTTTTGAGACTGAGTTTTCACTCTTGTTGCCCAGGCTGGAGTGCAATGGCGTGATCTCGGCTTACT
GCAACCTCTGCTTCCTGGGTTCAAGCAATTCTCCAGCCTCAACCTCCTGAGAAGCTGGGATTACAGGTGCCTGCCACCACGCCTGGCTAA
TTTTTGTACTTTTAGTAGACACAGGGTTTCACCATGTTTGCCAGGCTGATCTCAAACTCCTGACCTCAGGTGAGCCACCCACCTCTGCCT
CCGAAAGTGCTGGGATTACAGGCGTGAGCCACCGTACCCGGCCCTTGTTATTGTTATTAATCATTATCAATCATTAACTTTACAGATATT
AAAGAAATAGGGGCCATGTTCTACATGCGACATTGTTTTCCTGGCACACAGTAGACAATTCAGGAAATGTCTGAAGAAGGAATGGGTAAA
ATTAAGATACCAAAATGGAATTGAGGGGAGAGCAGGTAATTGTAGAGAAAAAGACTCTTTATGGCAAGAAACAAAGTAAAAGAAATGTAT
AGACCGGGCGCGGTGGCTCACGCCTGTAATCCCAGCAATTTGGAAGGCCGAGGCGGGCGGATCACGAGGTCAGGAGATCGAGACCGTCCT
GGCTAACACGGTGAAACCCTGTCTCTACTAAAAAACACAAAACAAATTAGCCAGGCGCGGTGGCAGGCGTCTGTAGTCCCAGCTACTGGG
GAGGCTGAGGCAAGAGAATGGCGGGAACCCGCGAGGCGGAGCTTGCAGTGAGTCGAGATCACGTCACTGCCCTCCAGCCTGGGCGACCAG
CGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGTATAAACCAGACTAAGAGGGGAATAAAAGCAAGAAGAAAA
AGAAACGTAAGAACACCAGTAAAGGAAAGACAGGGACCGAGACAGGTGGTTAAGGGAAATGAAAAAAAAAAAAAAAAGGTGAAAGTCAAT
CCAAACAAAGAAAAATGGCACTTCCAACCAAAAAAAATGAAGGTGTAGAACCCTGTCATCAATTGCTCAGAAAAGAGAGACACTTGAGCA
GGGAGGGGTTTGAGAAAGGGGAGAAGGAAGGAGTGAGAGCCCTAAAAAATAATGTTCCTAGCTACCCTTTACAGCTGTCTCTGCAGGGAA
GACTGGAGAAAGTAGAGGGGGAAATGAATGCAGGAAGAAACTGCCTCTGCAGAGCAGGTAAGAGGAGGTTGTTCAGATTTATGGATTTTA
TTAAGCCAGTTTTCTGTATCACTCTGCTATAAAGGAAAATAGCTTCTGCAGGGCTGTCTCTCCTCCTTCAGGTGGGGAACAAAGGGTGGG
TGGAGTCAGGGACAGAGTCTGGTCTGCGAGATCGTGACGTGTCTGCAGCTCCGAAGCACTGCAGGTGTTTCTGGGTAATGTGCCACATCA
TGTTTATATCACGAACGGGAATTGAAAATCAGTCTGTGTGAGGCAGAGATGAGCCCACATCTGTTATCCTCCCCAACAATAAATAAATAA
ATAGCCCAGACAAATGGATGCCAGTCCATCTACAGCAACATTTTAAAGCATGTGCTTTATGACAAAACTGGACCCAGGGTCTGACAGAGA
CTGCAGGCTGCCGTGAGCACTGTAGCTATCCTGAACATTGATGCTACATATTGCTAAGGGGAACATAATTTATAGCATAAACCCTACAAG
CTTCCACTAAGGTTGAGTTTTCCTCTCATTTTCTTGCCGTTTTATTGGCTTCACTGCATGGTTGCCAATAGCAACATCCACTGGTAGCAA
GGGGAGTTCAACACCATTGCAATCTGCCATACAGTGGAGCCCTGACAATGTCAACCATCAATCTAGTAGCTGTTTGTAATTGCCTCCATC
TATTTCTCCTGTCTTGAGGTATCTTTCCTATTGTGGGTCAAGATTTAGAAACTGCTGACTAATGCCATGGGTCTGTGTCTCCATGACTAT
GAAGCAGTGGACAGGAAGGTAGCAGCTTCCTGGTGCCAACAACCCCAGAGGTTAGAGGTTGAACTCTTGCGGGTTTCAGGCGTTTTTAAT
CCCTTTTCTAAACAATTTATAATTTTGCAAGAATGTGAGGCATATGCAGTTATCCATATAATCTGCTTTTCCAAAAAAGAGAAAGGAAGT
TTCCCAGTCCTTATTATTAATGTTTATTTCCTATTGGAGAAAGACATTTGAAATATGAGCCTTCTTGTAAAAACTCAAACTGACCAGATT
ATGTTTGCTTCCTCAGGTCTCTTGGCATTAATTGTTGAAATAACTTCATCCTACTTTTTCGATGAGATGTATTTTTTTCAGACATATTTA
TTCTTACTAGTCACTATGTAGCTATTATGTGCACAATCTACAATGTAGTGGCAATCCTGGTGGGTAGGGACAGCTTCACATACTGCAAAG
GGTGCCATTCAGTGCATAGCAGACTGGAACTCCCTCCTAGCTTGGCCACCAGCTGAACCTGTAATCTTAGGACTCTCCAAGTCTTAGAAT
CTCCATCTATTACATAAAAGCACTGACTTTTATTCAGTCCCCACACCAAAGGACCAAGACGTGTTTAGCTTTAAAGAAATTTTCCAGATA
ATTTTCTTTTTTATTCTTCTCAAATAAAATAGCAACAAACCTAAAGCAGTCATCTTCTTAATAAAGACATAATAAAACTTACATATATGG
GGTAGATGTAAGCACAATCATACTACAGATGTATCTTGAGCCTGTCTCTAATTATGATGAAAGATGTAGTCATCAATACAATTTAAAAAA
AGATATGTCCTTTTTTTGAGACAGGGTCTTGCTCTGTCACCCAGGCTGGAGGGCAGTGGCACAATCACAGCCACTGCAGCCTTGACCTCT
CCAACTTAAGTGATCTTTCCTGCCTCAGCCTCATGAGTAGCTGGGACCACAGGTGTGCACCACCACACCCAGCTAAATTTTGTATTGTTT
GTAAAGACGAGGCCTCACTATGCTGACCACACTGGTCTCGAACTCCTGGGCTCAAGCAATCCTCCTGCCTTGGCCTCCCAAAGTGTTAGG
GTTAGAGATATGAACCACCACACCCACCTTATATGTCCTTTTATTTCATAAAAAACAATTTTAGATTATCTGATATCACACATATCCCAT
AAATGGTAGTCATTAATTTAGAAGTGAATTTATAAAGTTAAGAGAAGTTAAAATTGCACATGCATTTTGTTTCTAAAATCTGAGATGTCT
ATGCATTTCCAGGTATTGTATATTTGCAAATACATTGGGTTAGAAATCATCTTTAACATTTTGTGTTAGTGTAATAACAATATTATCTAA
TATTAATGCTGCCAGAATCCAGTTGCTTTTTCTGTGTATCAAAATTTATCATAACTTTTTCCACTTAACACTAGGTAATTAAACAGAATC
TGCCCAATTTATTCTGCAGTAAAATTATTTTAAAATCTATTTTTCCTGCTGACTCTTAGAAATTGCAGAAAGACAAAAACCAGTTTCATC
TCCAGTAATAGTGTGAAACAATTTCCTTCCAGTGGGACAGAAACCTAGACATACTAGGGAAAGATTTAAATATAAAGAAAAATGCCTTGG
CTGAAAAAAAAAAAAACCACCAAAACACAAAAAGGATTCATTAAAGCAACAGAACAAAACCTAATTTGGGACCCTAAAAACTCTGGCAAT
GCCACTGTAATGAAGTTTCATTATCTGCTTCAGAGTAACAGTCTCTGAAATTGTTATTCTGCTACATGCTGTAAAGAACTCCCAAAACTC
AAATGTATCAGGAAATGTAAAGGTTAAGTCTGACTACAAGAAGGCCAAAATTGCACCAGCTTCCTAAGTGAAGAATAATAGAATAAAACA
TATAGAGGGCAGAAATAAAATGAGGTGTATCTGGAGAATTTCATGATGAGCATTTAGATTTAGCAATGCCCAATGTCATGCTGACACTGT
TTGTCATGACCTTGTCTTCAGCTAGTAATTTGGGGTTGTACTTTTTTAAATTTAATTTTGAATGTTCTTGCATGTTTGGTACCTCTCTCC
TCACTGCTAAAGATAAATTGTTTATCTGTATAACATAACTACACCAATGTCATTTTTGTATACGCTAGTACACAAATGTGTTTTTTTATT
AAGTAATGAAGTATTTGCTGTGAAAAATGTATTATTTGTGCCACCGTTTATATCTGTGTTCATTTTCTGTGTGTATATGCGTGTGTATTC
GAATCTCAATTTTTCTTTTACTCTAGTTTAGATTAAGACATATTTAGATGAAATTTTAAAAATAACATTGGAAATAGGAGGCTAAGTTTT
GTTGAGTCTCATTCCCTTGGGGGGAAATTGCTTTTGCCATTTTATTTTCATGTACAATAACCTAAAAAGGATCTCCTACTGACTTCCTTC
CTAATTATTATTGTTTTACACGAAAGAAAGGAAATACGTTTTCAATTGAGTTGTTTGAAATCATTCACTTTGTGTAGATTTCCCAGACTG
ATGTTTCATTGTAAGAATATTACATTATAGACAGGTTGGCCATTTCACAAGCAACTAATCCATAGTTTTGGAAGCCCGCTTTAAGAGACC

>74084_74084_1_RIF1-PDE11A_RIF1_chr2_152318980_ENST00000243326_PDE11A_chr2_178592900_ENST00000286063_length(amino acids)=1483AA_BP=1146
MGRRGAVSIGHWIFSSSGSGLRVADMTARGQSPLAPLLETLEDPSASHGGQTDAYLTLTSRMTGEEGKEVITEIEKKLPRLYKVLKTHIS
SQNSELSSAALQALGFCLYNPKITSELSEANALELLSKLNDTIKNSDKNVRTRALWVISKQTFPSEVVGKMVSSIIDSLEILFNKGETHS
AVVDFEALNVIVRLIEQAPIQMGEEAVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEIASITEQLMTTKLISELQKLFMSKN
ETYVLKLWPLFVKLLGRTLHRSGSFINSLLQLEELGFRSGAPMIKKIAFIAWKSLIDNFALNPDILCSAKRLKLLMQPLSSIHVRTETLA
LTKLEVWWYLLMRLGPHLPANFEQVCVPLIQSTISIDSNASPQGNSCHVATSPGLNPMTPVHKGASSPYGAPGTPRMNLSSNLGGMATIP
SIQLLGLEMLLHFLLGPEALSFAKQNKLVLSLEPLEHPLISSPSFFSKHANTLITAVHDSFVAVGKDAPDVVVSAIWKELISLVKSVTES
GNKKEKPGSEVLTLLLKSLESIVKSEVFPVSKTLVLMEITIKGLPQKVLGSPAYQVANMDILNGTPALFLIQLIFNNFLECGVSDERFFL
SLESLVGCVLSGPTSPLAFSDSVLNVINQNAKQLENKEHLWKMWSVIVTPLTELINQTNEVNQGDALEHNFSAIYGALTLPVNHIFSEQR
FPVATMKTLLRTWSELYRAFARCAALVATAEENLCCEELSSKIMSSLEDEGFSNLLFVDRIIYIITVMVDCIDFSPYNIKYQPKVKSPQR
PSDWSKKKNEPLGKLTSLFKLIVKVIYSFHTLSFKEAHSDTLFTIGNSITGIISSVLGHISLPSMIRKIFATLTRPLALFYENSKLDEVP
KVYSCLNNKLEKLLGEIIACLQFSYTGTYDSELLEQLSPLLCIIFLHKNKQIRKQSAQFWNATFAKVMMLVYPEELKPVLTQAKQKFLLL
LPGLETVEMMEESSGPYSDGTENSQLNVKISGMERKSNGKRDSFLAQTKNKKENMKPAAKLKLESSSLKVKGEILLEEEKSTDFVFIPPE
GKDAKERILTDHQKEVLKTKRCDIPAMYNNLDVSQDTLFTQYSQEEPMEIPTLTRKPKEDSKMMITAANIPLVSELAIDDIHFDDFSLDV
DAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRG
TNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNI
KNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVK

--------------------------------------------------------------
>74084_74084_2_RIF1-PDE11A_RIF1_chr2_152318980_ENST00000243326_PDE11A_chr2_178592900_ENST00000358450_length(transcript)=6198nt_BP=3846nt
TGAGTAAACAGCCGGAGCTGGGAAAGTCGAGCTCTGGCAGCGTCTGGGTGCTGAGGGGCAGAGGCGGAGAGAACCCTGTCCTGATCTTCC
TAGGTGGGATAAATATCGGGGTGACAGTGGTAGGCCGCGGGGAACCCTCAGTCTGCCCACCCTCCGCCCCCTCGCGGCGAGATGCCTCGT
TCCCCGGGCTTCTCCCGCCCTCCGCCGATCTCCTCCCTCTGTTGAAAGCTGCCCGGGAAAGTGGTGGCGGGAGCGGGCCCAGGCCCGAAT
GTGGCGTGGGCTCAGGTGTCTGGTGTCGGGCGCCGGAGGAGGTTCGCGCTGGGGTTTGGTGATTCGGAGGCCTGGGGTGCAGACGCGGCG
TGGCTGTGAGGCCCGGGCGGGCGTGCGGGTGTGAGGGCCGGACTCACACTGGGCCGCCGCGGGGCTGTTTCCATCGGTCACTGGATTTTC
TCCTCTTCCGGTTCGGGCCTCAGGGTGGCCGACATGACGGCCAGGGGTCAGAGCCCCCTCGCGCCGCTGTTGGAGACTTTGGAAGACCCT
TCTGCCTCCCATGGAGGGCAGACTGACGCTTACCTGACTCTGACCAGTCGTATGACTGGAGAAGAAGGAAAAGAAGTAATTACAGAAATT
GAGAAAAAACTTCCTCGGCTGTACAAAGTTTTAAAGACTCACATTTCCAGTCAAAACTCGGAGCTGAGTAGTGCTGCTCTACAAGCCCTG
GGGTTTTGCTTATATAATCCCAAAATTACCTCAGAATTATCAGAGGCAAATGCTCTAGAATTGCTTTCAAAATTGAATGATACCATTAAG
AATTCAGACAAAAATGTACGTACTAGAGCACTTTGGGTGATATCTAAGCAGACATTTCCCTCTGAAGTGGTTGGCAAAATGGTATCCAGT
ATAATTGATTCATTAGAAATACTGTTTAACAAAGGAGAGACGCATTCTGCTGTTGTTGATTTTGAAGCATTAAATGTTATCGTAAGGCTA
ATTGAACAAGCCCCAATTCAAATGGGAGAAGAGGCAGTGAGGTGGGCAAAACTGGTCATACCTTTAGTGGTTCATTCAGCACAAAAGGTA
CATTTGCGGGGAGCAACTGCTCTGGAGATGGGAATGCCATTATTGCTTCAGAAACAGCAAGAAATAGCATCTATTACGGAGCAGCTTATG
ACTACTAAATTAATCTCAGAACTTCAGAAGCTATTTATGAGTAAAAATGAGACTTACGTGTTAAAATTATGGCCTTTGTTTGTCAAACTA
CTTGGAAGGACCTTGCATCGAAGTGGGAGTTTCATCAATTCTCTCTTGCAACTAGAAGAACTTGGATTTCGTAGTGGAGCACCCATGATT
AAAAAGATAGCTTTTATTGCTTGGAAGAGTTTAATAGATAATTTTGCTTTAAATCCAGATATACTATGTAGTGCAAAAAGACTCAAGTTG
TTAATGCAGCCTTTGAGTTCCATCCATGTGAGAACAGAAACTCTAGCATTAACAAAACTAGAAGTCTGGTGGTATTTACTGATGAGACTT
GGACCTCATCTTCCTGCTAATTTTGAACAGGTTTGTGTGCCTCTGATTCAAAGTACAATAAGCATTGATTCTAATGCCTCACCTCAGGGC
AATTCGTGTCATGTAGCTACATCTCCAGGTTTAAATCCTATGACTCCTGTACACAAAGGTGCTTCCTCCCCGTACGGAGCCCCGGGAACT
CCCCGAATGAACCTGAGTTCGAATTTAGGTGGAATGGCCACAATCCCATCCATTCAACTTTTGGGACTTGAAATGTTGCTTCATTTCTTG
TTGGGTCCAGAAGCCTTGAGTTTTGCTAAGCAAAATAAACTTGTGCTGAGCTTAGAGCCATTGGAACATCCGTTAATCAGCAGCCCTTCC
TTTTTTTCCAAACATGCAAATACACTTATCACTGCTGTTCATGATAGCTTTGTTGCAGTTGGAAAAGATGCCCCCGATGTGGTTGTCAGT
GCTATCTGGAAGGAGCTAATTAGCTTGGTGAAGTCAGTTACTGAATCAGGTAACAAAAAAGAGAAACCAGGTTCTGAAGTTTTGACTCTC
TTATTAAAGTCTTTGGAAAGCATAGTAAAGTCTGAAGTATTTCCTGTATCAAAAACGCTGGTCCTCATGGAAATTACAATTAAAGGACTT
CCTCAGAAAGTATTAGGTTCACCAGCATATCAGGTTGCTAATATGGATATTCTTAATGGAACTCCAGCTTTGTTCTTAATTCAATTAATT
TTCAACAATTTCTTGGAATGTGGTGTATCAGATGAAAGGTTCTTTCTCAGTTTGGAATCACTTGTAGGCTGTGTTCTTTCTGGTCCAACT
TCACCACTAGCTTTCAGTGACTCAGTTTTAAATGTTATTAATCAAAATGCAAAGCAGTTGGAAAATAAGGAGCATCTCTGGAAAATGTGG
AGTGTTATAGTCACCCCATTAACTGAATTGATTAATCAGACCAATGAAGTAAATCAAGGTGATGCCTTAGAACATAATTTTAGTGCCATC
TATGGTGCATTGACTTTACCAGTAAACCACATTTTTTCAGAACAGAGATTTCCAGTGGCCACCATGAAGACTTTGCTTAGAACTTGGTCA
GAATTATATAGAGCATTTGCTCGTTGTGCTGCTTTGGTGGCAACAGCAGAAGAGAACTTGTGCTGTGAGGAACTTTCTTCCAAGATAATG
TCCAGTTTGGAAGATGAAGGCTTTTCTAATTTGTTGTTCGTGGATAGAATTATTTATATTATTACTGTAATGGTTGATTGCATTGACTTC
TCACCATATAATATTAAATATCAGCCCAAAGTTAAATCACCACAGAGACCTTCAGATTGGTCCAAAAAGAAGAATGAGCCCCTAGGGAAA
TTGACTTCTTTATTTAAACTTATTGTGAAAGTGATCTATTCTTTCCACACACTGAGCTTCAAGGAAGCACATTCTGATACCCTCTTCACT
ATTGGCAACTCAATCACCGGCATTATTTCCAGTGTACTTGGGCATATTTCTTTGCCTTCTATGATCCGAAAAATATTTGCAACTTTAACA
AGACCTCTGGCATTATTTTATGAAAACTCAAAGCTTGATGAAGTTCCTAAAGTATATAGTTGTCTGAACAACAAGTTAGAAAAGCTACTG
GGAGAAATTATTGCTTGTCTGCAATTCAGCTACACCGGAACTTATGATAGTGAACTTCTTGAACAACTCTCCCCACTATTATGCATAATA
TTTCTGCACAAGAATAAACAGATTCGAAAACAGAGTGCTCAGTTCTGGAATGCCACTTTTGCCAAAGTGATGATGTTGGTTTATCCTGAA
GAGTTAAAACCAGTACTAACACAAGCCAAACAAAAATTTCTGCTCCTGTTGCCTGGTTTGGAAACTGTTGAAATGATGGAGGAATCCAGT
GGACCATATTCTGATGGAACAGAAAATTCACAACTAAATGTGAAGATAAGTGGCATGGAGAGAAAATCAAATGGAAAAAGAGATTCATTT
TTGGCACAAACAAAGAATAAAAAAGAAAATATGAAACCAGCAGCCAAACTGAAACTTGAATCTTCGTCTTTAAAAGTAAAGGGTGAAATT
CTTTTGGAAGAGGAAAAGTCTACTGACTTTGTGTTTATACCTCCAGAAGGAAAAGATGCAAAGGAAAGAATATTAACTGATCATCAAAAA
GAAGTTCTCAAAACAAAGCGGTGTGATATTCCTGCCATGTATAATAATCTGGATGTTTCCCAAGATACCTTATTTACTCAGTATAGTCAG
GAAGAGCCTATGGAAATTCCTACTTTAACCAGAAAACCAAAGGAGGATTCTAAGATGATGATTACGGCAGCCAACATCCCTCTGGTGTCA
GAACTTGCCATCGATGACATTCATTTTGATGACTTTTCTCTCGACGTTGATGCCATGATCACAGCTGCTCTCCGGATGTTCATGGAGCTG
GGGATGGTACAGAAATTTAAAATTGACTATGAGACACTGTGTAGGTGGCTTTTGACAGTGAGGAAAAACTATCGGATGGTTCTATACCAC
AACTGGAGACATGCCTTCAACGTGTGTCAGCTGATGTTCGCGATGTTAACCACTGCTGGGTTTCAAGACATTCTGACCGAGGTGGAAATT
TTAGCGGTGATTGTGGGATGCCTGTGTCATGACCTCGACCACAGGGGAACCAACAATGCCTTCCAAGCTAAGAGTGGCTCTGCCCTGGCC
CAACTCTATGGAACCTCTGCTACCTTGGAGCATCACCATTTCAACCACGCCGTGATGATCCTTCAAAGTGAGGGTCACAATATCTTTGCT
AACCTGTCCTCCAAGGAATATAGTGACCTTATGCAGCTTTTGAAGCAGTCAATATTGGCAACAGACCTCACGCTGTACTTTGAGAGGAGA
ACTGAATTCTTTGAACTTGTCAGTAAAGGAGAATACGATTGGAACATCAAAAACCATCGTGATATATTTCGATCAATGTTAATGACAGCC
TGTGACCTTGGAGCCGTGACCAAACCGTGGGAGATCTCCAGACAGGTGGCAGAACTTGTAACCAGTGAGTTCTTCGAACAAGGAGATCGG
GAGAGATTAGAGCTCAAACTCACTCCTTCAGCAATTTTTGATCGGAACCGGAAGGATGAACTGCCTCGGTTGCAACTGGAGTGGATTGAT
AGCATCTGCATGCCTTTGTATCAGGCACTGGTGAAGGTCAACGTGAAACTGAAGCCGATGCTAGATTCAGTAGCTACAAACAGAAGTAAG
TGGGAAGAGCTACACCAAAAACGACTGCTGGCCTCAACTGCCTCATCCTCCCCTGCCAGTGTTATGGTAGCCAAGGAAGACAGGAACTAA
ACCTCCAGGTCAGCTGCAGCTGCAAAATGACTACAGCCTGAAGGGCCATTTTCAGTCCAGCAATGTCATCCTTTTGTTCTTTTAGCTCAG
AAAGACCTAACATCTCAAGGATGCACTGGGAAGCATGCCTGGGCTTTCACCTTGAAGCATGGTCAGCAGCAGAGAGAGCAACGGGAAGGA
CAAAGAAAGAGGTGGGGCAGGGAGCACACCCCAGGACCCTCACTTTTCCCTAATGAACACGCATGGGCTGAAATGAAGGCTCTGGGTAGG
GGACTGTTTTGGATCCAAGGACCTGTGGACAGTCGGCCTACTTACTCTGAGCTGAGGGAACACTGAACAGTAAAAGCGTCATTAGCGCTG
CTTCGTTTTGTATAGGGCTTTTCTGTTTGTTACAAGCCAAACACTGCCTGTCTTTGCTTCCTGTCCCTGAATGCCTTTTTGTGCCAGACT
GTCCCAAGAATCCTAATTTGTATTCCATAGAGGTATTTTATTTTTAATCCTAGAGCTTCTTATTGATGGATCCTTTAGAATTGCCTACCT
AAAAGGTAAACTATACTATCCTTATAAATACTGATCAATCCCAGTTCTCCCCCTAAAAATGAATACATAGTAGGACTATAGCAAATGTGT
TTGATGGGTAATTCTAGACTGGGACTATGGTACCCTTTTCCAGAGTTTTAAAATTCAACCTTCATTACAGACAAAGTTTTCTCCCAGAAG
GAATGGATTGATAGATTTTGATTAAAGTAAGGGTGGAAGGAAATCTGTAGCTGGATTTACCACAAGTGACATCTAGAAACTATAGTTCAC
AGGACAGAGCAGAGCCATGGAGACTAAGCATTGACTACCTTGAGTTCTCCTAGTGAGGAGTTCTGGTATAAAATTTAAGATTACTACCAG
TAACCAACTTAAAGCAAACTATAGGGGTCCCTAATTTTGGATTTTTCCTTAAGTGTAAGAAACAATGCTTCAAATGTTAAGAAATAACAG
TCTGGGCAAAGAACGCATATTCTATAGGAAGCCAGGTTTACAATAGGTAAGAATAAACTGTATTAAGTAGATGTAATGACTAGAAAGCTG
CTTTGCTCCCTATATTGAGAAATTGTGGACATGGTATGTGTTATCCAAAGAACATTGGGCTAGAAGATAGATTTCTATCCTTAGCTTTGG
CATTATTGACTGGATTGACTTGAACAAGTCACTTAACTTCTACAAGCTTGTTTCCTTATTTGTCAAATTAGATTACACTAGGAAACGATT

>74084_74084_2_RIF1-PDE11A_RIF1_chr2_152318980_ENST00000243326_PDE11A_chr2_178592900_ENST00000358450_length(amino acids)=1483AA_BP=1146
MGRRGAVSIGHWIFSSSGSGLRVADMTARGQSPLAPLLETLEDPSASHGGQTDAYLTLTSRMTGEEGKEVITEIEKKLPRLYKVLKTHIS
SQNSELSSAALQALGFCLYNPKITSELSEANALELLSKLNDTIKNSDKNVRTRALWVISKQTFPSEVVGKMVSSIIDSLEILFNKGETHS
AVVDFEALNVIVRLIEQAPIQMGEEAVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEIASITEQLMTTKLISELQKLFMSKN
ETYVLKLWPLFVKLLGRTLHRSGSFINSLLQLEELGFRSGAPMIKKIAFIAWKSLIDNFALNPDILCSAKRLKLLMQPLSSIHVRTETLA
LTKLEVWWYLLMRLGPHLPANFEQVCVPLIQSTISIDSNASPQGNSCHVATSPGLNPMTPVHKGASSPYGAPGTPRMNLSSNLGGMATIP
SIQLLGLEMLLHFLLGPEALSFAKQNKLVLSLEPLEHPLISSPSFFSKHANTLITAVHDSFVAVGKDAPDVVVSAIWKELISLVKSVTES
GNKKEKPGSEVLTLLLKSLESIVKSEVFPVSKTLVLMEITIKGLPQKVLGSPAYQVANMDILNGTPALFLIQLIFNNFLECGVSDERFFL
SLESLVGCVLSGPTSPLAFSDSVLNVINQNAKQLENKEHLWKMWSVIVTPLTELINQTNEVNQGDALEHNFSAIYGALTLPVNHIFSEQR
FPVATMKTLLRTWSELYRAFARCAALVATAEENLCCEELSSKIMSSLEDEGFSNLLFVDRIIYIITVMVDCIDFSPYNIKYQPKVKSPQR
PSDWSKKKNEPLGKLTSLFKLIVKVIYSFHTLSFKEAHSDTLFTIGNSITGIISSVLGHISLPSMIRKIFATLTRPLALFYENSKLDEVP
KVYSCLNNKLEKLLGEIIACLQFSYTGTYDSELLEQLSPLLCIIFLHKNKQIRKQSAQFWNATFAKVMMLVYPEELKPVLTQAKQKFLLL
LPGLETVEMMEESSGPYSDGTENSQLNVKISGMERKSNGKRDSFLAQTKNKKENMKPAAKLKLESSSLKVKGEILLEEEKSTDFVFIPPE
GKDAKERILTDHQKEVLKTKRCDIPAMYNNLDVSQDTLFTQYSQEEPMEIPTLTRKPKEDSKMMITAANIPLVSELAIDDIHFDDFSLDV
DAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRG
TNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNI
KNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVK

--------------------------------------------------------------
>74084_74084_3_RIF1-PDE11A_RIF1_chr2_152318980_ENST00000428287_PDE11A_chr2_178592900_ENST00000286063_length(transcript)=10596nt_BP=3427nt
ACTCCTGGGCCCGCCCAGCCGCCATCTTGGTCTAGGAGGGAGCGCGCCGCACGCGGTGGCCGACATGACGGCCAGGGGTCAGAGCCCCCT
CGCGCCGCTGTTGGAGACTTTGGAAGACCCTTCTGCCTCCCATGGAGGGCAGACTGACGCTTACCTGACTCTGACCAGTCGTATGACTGG
AGAAGAAGGAAAAGAAGTAATTACAGAAATTGAGAAAAAACTTCCTCGGCTGTACAAAGTTTTAAAGACTCACATTTCCAGTCAAAACTC
GGAGCTGAGTAGTGCTGCTCTACAAGCCCTGGGGTTTTGCTTATATAATCCCAAAATTACCTCAGAATTATCAGAGGCAAATGCTCTAGA
ATTGCTTTCAAAATTGAATGATACCATTAAGAATTCAGACAAAAATGTACGTACTAGAGCACTTTGGGTGATATCTAAGCAGACATTTCC
CTCTGAAGTGGTTGGCAAAATGGTATCCAGTATAATTGATTCATTAGAAATACTGTTTAACAAAGGAGAGACGCATTCTGCTGTTGTTGA
TTTTGAAGCATTAAATGTTATCGTAAGGCTAATTGAACAAGCCCCAATTCAAATGGGAGAAGAGGCAGTGAGGTGGGCAAAACTGGTCAT
ACCTTTAGTGGTTCATTCAGCACAAAAGGTACATTTGCGGGGAGCAACTGCTCTGGAGATGGGAATGCCATTATTGCTTCAGAAACAGCA
AGAAATAGCATCTATTACGGAGCAGCTTATGACTACTAAATTAATCTCAGAACTTCAGAAGCTATTTATGAGTAAAAATGAGACTTACGT
GTTAAAATTATGGCCTTTGTTTGTCAAACTACTTGGAAGGACCTTGCATCGAAGTGGGAGTTTCATCAATTCTCTCTTGCAACTAGAAGA
ACTTGGATTTCGTAGTGGAGCACCCATGATTAAAAAGATAGCTTTTATTGCTTGGAAGAGTTTAATAGATAATTTTGCTTTAAATCCAGA
TATACTATGTAGTGCAAAAAGACTCAAGTTGTTAATGCAGCCTTTGAGTTCCATCCATGTGAGAACAGAAACTCTAGCATTAACAAAACT
AGAAGTCTGGTGGTATTTACTGATGAGACTTGGACCTCATCTTCCTGCTAATTTTGAACAGGTTTGTGTGCCTCTGATTCAAAGTACAAT
AAGCATTGATTCTAATGCCTCACCTCAGGGCAATTCGTGTCATGTAGCTACATCTCCAGGTTTAAATCCTATGACTCCTGTACACAAAGG
TGCTTCCTCCCCGTACGGAGCCCCGGGAACTCCCCGAATGAACCTGAGTTCGAATTTAGGTGGAATGGCCACAATCCCATCCATTCAACT
TTTGGGACTTGAAATGTTGCTTCATTTCTTGTTGGGTCCAGAAGCCTTGAGTTTTGCTAAGCAAAATAAACTTGTGCTGAGCTTAGAGCC
ATTGGAACATCCGTTAATCAGCAGCCCTTCCTTTTTTTCCAAACATGCAAATACACTTATCACTGCTGTTCATGATAGCTTTGTTGCAGT
TGGAAAAGATGCCCCCGATGTGGTTGTCAGTGCTATCTGGAAGGAGCTAATTAGCTTGGTGAAGTCAGTTACTGAATCAGGTAACAAAAA
AGAGAAACCAGGTTCTGAAGTTTTGACTCTCTTATTAAAGTCTTTGGAAAGCATAGTAAAGTCTGAAGTATTTCCTGTATCAAAAACGCT
GGTCCTCATGGAAATTACAATTAAAGGACTTCCTCAGAAAGTATTAGGTTCACCAGCATATCAGGTTGCTAATATGGATATTCTTAATGG
AACTCCAGCTTTGTTCTTAATTCAATTAATTTTCAACAATTTCTTGGAATGTGGTGTATCAGATGAAAGGTTCTTTCTCAGTTTGGAATC
ACTTGTAGGCTGTGTTCTTTCTGGTCCAACTTCACCACTAGCTTTCAGTGACTCAGTTTTAAATGTTATTAATCAAAATGCAAAGCAGTT
GGAAAATAAGGAGCATCTCTGGAAAATGTGGAGTGTTATAGTCACCCCATTAACTGAATTGATTAATCAGACCAATGAAGTAAATCAAGG
TGATGCCTTAGAACATAATTTTAGTGCCATCTATGGTGCATTGACTTTACCAGTAAACCACATTTTTTCAGAACAGAGATTTCCAGTGGC
CACCATGAAGACTTTGCTTAGAACTTGGTCAGAATTATATAGAGCATTTGCTCGTTGTGCTGCTTTGGTGGCAACAGCAGAAGAGAACTT
GTGCTGTGAGGAACTTTCTTCCAAGATAATGTCCAGTTTGGAAGATGAAGGCTTTTCTAATTTGTTGTTCGTGGATAGAATTATTTATAT
TATTACTGTAATGGTTGATTGCATTGACTTCTCACCATATAATATTAAATATCAGCCCAAAGTTAAATCACCACAGAGACCTTCAGATTG
GTCCAAAAAGAAGAATGAGCCCCTAGGGAAATTGACTTCTTTATTTAAACTTATTGTGAAAGTGATCTATTCTTTCCACACACTGAGCTT
CAAGGAAGCACATTCTGATACCCTCTTCACTATTGGCAACTCAATCACCGGCATTATTTCCAGTGTACTTGGGCATATTTCTTTGCCTTC
TATGATCCGAAAAATATTTGCAACTTTAACAAGACCTCTGGCATTATTTTATGAAAACTCAAAGCTTGATGAAGTTCCTAAAGTATATAG
TTGTCTGAACAACAAGTTAGAAAAGCTACTGGGAGAAATTATTGCTTGTCTGCAATTCAGCTACACCGGAACTTATGATAGTGAACTTCT
TGAACAACTCTCCCCACTATTATGCATAATATTTCTGCACAAGAATAAACAGATTCGAAAACAGAGTGCTCAGTTCTGGAATGCCACTTT
TGCCAAAGTGATGATGTTGGTTTATCCTGAAGAGTTAAAACCAGTACTAACACAAGCCAAACAAAAATTTCTGCTCCTGTTGCCTGGTTT
GGAAACTGTTGAAATGATGGAGGAATCCAGTGGACCATATTCTGATGGAACAGAAAATTCACAACTAAATGTGAAGATAAGTGGCATGGA
GAGAAAATCAAATGGAAAAAGAGATTCATTTTTGGCACAAACAAAGAATAAAAAAGAAAATATGAAACCAGCAGCCAAACTGAAACTTGA
ATCTTCGTCTTTAAAAGTAAAGGGTGAAATTCTTTTGGAAGAGGAAAAGTCTACTGACTTTGTGTTTATACCTCCAGAAGGAAAAGATGC
AAAGGAAAGAATATTAACTGATCATCAAAAAGAAGTTCTCAAAACAAAGCGGTGTGATATTCCTGCCATGTATAATAATCTGGATGTTTC
CCAAGATACCTTATTTACTCAGTATAGTCAGGAAGAGCCTATGGAAATTCCTACTTTAACCAGAAAACCAAAGGAGGATTCTAAGATGAT
GATTACGGCAGCCAACATCCCTCTGGTGTCAGAACTTGCCATCGATGACATTCATTTTGATGACTTTTCTCTCGACGTTGATGCCATGAT
CACAGCTGCTCTCCGGATGTTCATGGAGCTGGGGATGGTACAGAAATTTAAAATTGACTATGAGACACTGTGTAGGTGGCTTTTGACAGT
GAGGAAAAACTATCGGATGGTTCTATACCACAACTGGAGACATGCCTTCAACGTGTGTCAGCTGATGTTCGCGATGTTAACCACTGCTGG
GTTTCAAGACATTCTGACCGAGGTGGAAATTTTAGCGGTGATTGTGGGATGCCTGTGTCATGACCTCGACCACAGGGGAACCAACAATGC
CTTCCAAGCTAAGAGTGGCTCTGCCCTGGCCCAACTCTATGGAACCTCTGCTACCTTGGAGCATCACCATTTCAACCACGCCGTGATGAT
CCTTCAAAGTGAGGGTCACAATATCTTTGCTAACCTGTCCTCCAAGGAATATAGTGACCTTATGCAGCTTTTGAAGCAGTCAATATTGGC
AACAGACCTCACGCTGTACTTTGAGAGGAGAACTGAATTCTTTGAACTTGTCAGTAAAGGAGAATACGATTGGAACATCAAAAACCATCG
TGATATATTTCGATCAATGTTAATGACAGCCTGTGACCTTGGAGCCGTGACCAAACCGTGGGAGATCTCCAGACAGGTGGCAGAACTTGT
AACCAGTGAGTTCTTCGAACAAGGAGATCGGGAGAGATTAGAGCTCAAACTCACTCCTTCAGCAATTTTTGATCGGAACCGGAAGGATGA
ACTGCCTCGGTTGCAACTGGAGTGGATTGATAGCATCTGCATGCCTTTGTATCAGGCACTGGTGAAGGTCAACGTGAAACTGAAGCCGAT
GCTAGATTCAGTAGCTACAAACAGAAGTAAGTGGGAAGAGCTACACCAAAAACGACTGCTGGCCTCAACTGCCTCATCCTCCCCTGCCAG
TGTTATGGTAGCCAAGGAAGACAGGAACTAAACCTCCAGGTCAGCTGCAGCTGCAAAATGACTACAGCCTGAAGGGCCATTTTCAGTCCA
GCAATGTCATCCTTTTGTTCTTTTAGCTCAGAAAGACCTAACATCTCAAGGATGCACTGGGAAGCATGCCTGGGCTTTCACCTTGAAGCA
TGGTCAGCAGCAGAGAGAGCAACGGGAAGGACAAAGAAAGAGGTGGGGCAGGGAGCACACCCCAGGACCCTCACTTTTCCCTAATGAACA
CGCATGGGCTGAAATGAAGGCTCTGGGTAGGGGACTGTTTTGGATCCAAGGACCTGTGGACAGTCGGCCTACTTACTCTGAGCTGAGGGA
ACACTGAACAGTAAAAGCGTCATTAGCGCTGCTTCGTTTTGTATAGGGCTTTTCTGTTTGTTACAAGCCAAACACTGCCTGTCTTTGCTT
CCTGTCCCTGAATGCCTTTTTGTGCCAGACTGTCCCAAGAATCCTAATTTGTATTCCATAGAGGTATTTTATTTTTAATCCTAGAGCTTC
TTATTGATGGATCCTTTAGAATTGCCTACCTAAAAGGTAAACTATACTATCCTTATAAATACTGATCAATCCCAGTTCTCCCCCTAAAAA
TGAATACATAGTAGGACTATAGCAAATGTGTTTGATGGGTAATTCTAGACTGGGACTATGGTACCCTTTTCCAGAGTTTTAAAATTCAAC
CTTCATTACAGACAAAGTTTTCTCCCAGAAGGAATGGATTGATAGATTTTGATTAAAGTAAGGGTGGAAGGAAATCTGTAGCTGGATTTA
CCACAAGTGACATCTAGAAACTATAGTTCACAGGACAGAGCAGAGCCATGGAGACTAAGCATTGACTACCTTGAGTTCTCCTAGTGAGGA
GTTCTGGTATAAAATTTAAGATTACTACCAGTAACCAACTTAAAGCAAACTATAGGGGTCCCTAATTTTGGATTTTTCCTTAAGTGTAAG
AAACAATGCTTCAAATGTTAAGAAATAACAGTCTGGGCAAAGAACGCATATTCTATAGGAAGCCAGGTTTACAATAGGTAAGAATAAACT
GTATTAAGTAGATGTAATGACTAGAAAGCTGCTTTGCTCCCTATATTGAGAAATTGTGGACATGGTATGTGTTATCCAAAGAACATTGGG
CTAGAAGATAGATTTCTATCCTTAGCTTTGGCATTATTGACTGGATTGACTTGAACAAGTCACTTAACTTCTACAAGCTTGTTTCCTTAT
TTGTCAAATTAGATTACACTAGGAAACGATTCTCGAACATGTTTTAACCTTACAACTCTTTGTTCAAATAAATCTTTCAATGAATCCCCA
ACATATAAAACGTCAAAAAGCTGAATTCCTATGTGAATTATAAGCAGGGTTTGGACATCCAGAGCACCTACAAACCTTCATCTCTTTGAT
TACGTACATGGGGGTCCACAGGGACTCTGAAGAGTTTGAAAATCCCTGGCCTAGATTAAACCTGAGAGCCATTCTAGCTCTTAAAAAAAT
CTGAAATTTACAAACCATTTTTCTTGTTATTGTTTTTGTTTCTTTGTTTGTTTGTTTTTTGAGACTGAGTTTTCACTCTTGTTGCCCAGG
CTGGAGTGCAATGGCGTGATCTCGGCTTACTGCAACCTCTGCTTCCTGGGTTCAAGCAATTCTCCAGCCTCAACCTCCTGAGAAGCTGGG
ATTACAGGTGCCTGCCACCACGCCTGGCTAATTTTTGTACTTTTAGTAGACACAGGGTTTCACCATGTTTGCCAGGCTGATCTCAAACTC
CTGACCTCAGGTGAGCCACCCACCTCTGCCTCCGAAAGTGCTGGGATTACAGGCGTGAGCCACCGTACCCGGCCCTTGTTATTGTTATTA
ATCATTATCAATCATTAACTTTACAGATATTAAAGAAATAGGGGCCATGTTCTACATGCGACATTGTTTTCCTGGCACACAGTAGACAAT
TCAGGAAATGTCTGAAGAAGGAATGGGTAAAATTAAGATACCAAAATGGAATTGAGGGGAGAGCAGGTAATTGTAGAGAAAAAGACTCTT
TATGGCAAGAAACAAAGTAAAAGAAATGTATAGACCGGGCGCGGTGGCTCACGCCTGTAATCCCAGCAATTTGGAAGGCCGAGGCGGGCG
GATCACGAGGTCAGGAGATCGAGACCGTCCTGGCTAACACGGTGAAACCCTGTCTCTACTAAAAAACACAAAACAAATTAGCCAGGCGCG
GTGGCAGGCGTCTGTAGTCCCAGCTACTGGGGAGGCTGAGGCAAGAGAATGGCGGGAACCCGCGAGGCGGAGCTTGCAGTGAGTCGAGAT
CACGTCACTGCCCTCCAGCCTGGGCGACCAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGTATAAACCA
GACTAAGAGGGGAATAAAAGCAAGAAGAAAAAGAAACGTAAGAACACCAGTAAAGGAAAGACAGGGACCGAGACAGGTGGTTAAGGGAAA
TGAAAAAAAAAAAAAAAAGGTGAAAGTCAATCCAAACAAAGAAAAATGGCACTTCCAACCAAAAAAAATGAAGGTGTAGAACCCTGTCAT
CAATTGCTCAGAAAAGAGAGACACTTGAGCAGGGAGGGGTTTGAGAAAGGGGAGAAGGAAGGAGTGAGAGCCCTAAAAAATAATGTTCCT
AGCTACCCTTTACAGCTGTCTCTGCAGGGAAGACTGGAGAAAGTAGAGGGGGAAATGAATGCAGGAAGAAACTGCCTCTGCAGAGCAGGT
AAGAGGAGGTTGTTCAGATTTATGGATTTTATTAAGCCAGTTTTCTGTATCACTCTGCTATAAAGGAAAATAGCTTCTGCAGGGCTGTCT
CTCCTCCTTCAGGTGGGGAACAAAGGGTGGGTGGAGTCAGGGACAGAGTCTGGTCTGCGAGATCGTGACGTGTCTGCAGCTCCGAAGCAC
TGCAGGTGTTTCTGGGTAATGTGCCACATCATGTTTATATCACGAACGGGAATTGAAAATCAGTCTGTGTGAGGCAGAGATGAGCCCACA
TCTGTTATCCTCCCCAACAATAAATAAATAAATAGCCCAGACAAATGGATGCCAGTCCATCTACAGCAACATTTTAAAGCATGTGCTTTA
TGACAAAACTGGACCCAGGGTCTGACAGAGACTGCAGGCTGCCGTGAGCACTGTAGCTATCCTGAACATTGATGCTACATATTGCTAAGG
GGAACATAATTTATAGCATAAACCCTACAAGCTTCCACTAAGGTTGAGTTTTCCTCTCATTTTCTTGCCGTTTTATTGGCTTCACTGCAT
GGTTGCCAATAGCAACATCCACTGGTAGCAAGGGGAGTTCAACACCATTGCAATCTGCCATACAGTGGAGCCCTGACAATGTCAACCATC
AATCTAGTAGCTGTTTGTAATTGCCTCCATCTATTTCTCCTGTCTTGAGGTATCTTTCCTATTGTGGGTCAAGATTTAGAAACTGCTGAC
TAATGCCATGGGTCTGTGTCTCCATGACTATGAAGCAGTGGACAGGAAGGTAGCAGCTTCCTGGTGCCAACAACCCCAGAGGTTAGAGGT
TGAACTCTTGCGGGTTTCAGGCGTTTTTAATCCCTTTTCTAAACAATTTATAATTTTGCAAGAATGTGAGGCATATGCAGTTATCCATAT
AATCTGCTTTTCCAAAAAAGAGAAAGGAAGTTTCCCAGTCCTTATTATTAATGTTTATTTCCTATTGGAGAAAGACATTTGAAATATGAG
CCTTCTTGTAAAAACTCAAACTGACCAGATTATGTTTGCTTCCTCAGGTCTCTTGGCATTAATTGTTGAAATAACTTCATCCTACTTTTT
CGATGAGATGTATTTTTTTCAGACATATTTATTCTTACTAGTCACTATGTAGCTATTATGTGCACAATCTACAATGTAGTGGCAATCCTG
GTGGGTAGGGACAGCTTCACATACTGCAAAGGGTGCCATTCAGTGCATAGCAGACTGGAACTCCCTCCTAGCTTGGCCACCAGCTGAACC
TGTAATCTTAGGACTCTCCAAGTCTTAGAATCTCCATCTATTACATAAAAGCACTGACTTTTATTCAGTCCCCACACCAAAGGACCAAGA
CGTGTTTAGCTTTAAAGAAATTTTCCAGATAATTTTCTTTTTTATTCTTCTCAAATAAAATAGCAACAAACCTAAAGCAGTCATCTTCTT
AATAAAGACATAATAAAACTTACATATATGGGGTAGATGTAAGCACAATCATACTACAGATGTATCTTGAGCCTGTCTCTAATTATGATG
AAAGATGTAGTCATCAATACAATTTAAAAAAAGATATGTCCTTTTTTTGAGACAGGGTCTTGCTCTGTCACCCAGGCTGGAGGGCAGTGG
CACAATCACAGCCACTGCAGCCTTGACCTCTCCAACTTAAGTGATCTTTCCTGCCTCAGCCTCATGAGTAGCTGGGACCACAGGTGTGCA
CCACCACACCCAGCTAAATTTTGTATTGTTTGTAAAGACGAGGCCTCACTATGCTGACCACACTGGTCTCGAACTCCTGGGCTCAAGCAA
TCCTCCTGCCTTGGCCTCCCAAAGTGTTAGGGTTAGAGATATGAACCACCACACCCACCTTATATGTCCTTTTATTTCATAAAAAACAAT
TTTAGATTATCTGATATCACACATATCCCATAAATGGTAGTCATTAATTTAGAAGTGAATTTATAAAGTTAAGAGAAGTTAAAATTGCAC
ATGCATTTTGTTTCTAAAATCTGAGATGTCTATGCATTTCCAGGTATTGTATATTTGCAAATACATTGGGTTAGAAATCATCTTTAACAT
TTTGTGTTAGTGTAATAACAATATTATCTAATATTAATGCTGCCAGAATCCAGTTGCTTTTTCTGTGTATCAAAATTTATCATAACTTTT
TCCACTTAACACTAGGTAATTAAACAGAATCTGCCCAATTTATTCTGCAGTAAAATTATTTTAAAATCTATTTTTCCTGCTGACTCTTAG
AAATTGCAGAAAGACAAAAACCAGTTTCATCTCCAGTAATAGTGTGAAACAATTTCCTTCCAGTGGGACAGAAACCTAGACATACTAGGG
AAAGATTTAAATATAAAGAAAAATGCCTTGGCTGAAAAAAAAAAAAACCACCAAAACACAAAAAGGATTCATTAAAGCAACAGAACAAAA
CCTAATTTGGGACCCTAAAAACTCTGGCAATGCCACTGTAATGAAGTTTCATTATCTGCTTCAGAGTAACAGTCTCTGAAATTGTTATTC
TGCTACATGCTGTAAAGAACTCCCAAAACTCAAATGTATCAGGAAATGTAAAGGTTAAGTCTGACTACAAGAAGGCCAAAATTGCACCAG
CTTCCTAAGTGAAGAATAATAGAATAAAACATATAGAGGGCAGAAATAAAATGAGGTGTATCTGGAGAATTTCATGATGAGCATTTAGAT
TTAGCAATGCCCAATGTCATGCTGACACTGTTTGTCATGACCTTGTCTTCAGCTAGTAATTTGGGGTTGTACTTTTTTAAATTTAATTTT
GAATGTTCTTGCATGTTTGGTACCTCTCTCCTCACTGCTAAAGATAAATTGTTTATCTGTATAACATAACTACACCAATGTCATTTTTGT
ATACGCTAGTACACAAATGTGTTTTTTTATTAAGTAATGAAGTATTTGCTGTGAAAAATGTATTATTTGTGCCACCGTTTATATCTGTGT
TCATTTTCTGTGTGTATATGCGTGTGTATTCGAATCTCAATTTTTCTTTTACTCTAGTTTAGATTAAGACATATTTAGATGAAATTTTAA
AAATAACATTGGAAATAGGAGGCTAAGTTTTGTTGAGTCTCATTCCCTTGGGGGGAAATTGCTTTTGCCATTTTATTTTCATGTACAATA
ACCTAAAAAGGATCTCCTACTGACTTCCTTCCTAATTATTATTGTTTTACACGAAAGAAAGGAAATACGTTTTCAATTGAGTTGTTTGAA
ATCATTCACTTTGTGTAGATTTCCCAGACTGATGTTTCATTGTAAGAATATTACATTATAGACAGGTTGGCCATTTCACAAGCAACTAAT

>74084_74084_3_RIF1-PDE11A_RIF1_chr2_152318980_ENST00000428287_PDE11A_chr2_178592900_ENST00000286063_length(amino acids)=1478AA_BP=1141
MGPPSRHLGLGGSAPHAVADMTARGQSPLAPLLETLEDPSASHGGQTDAYLTLTSRMTGEEGKEVITEIEKKLPRLYKVLKTHISSQNSE
LSSAALQALGFCLYNPKITSELSEANALELLSKLNDTIKNSDKNVRTRALWVISKQTFPSEVVGKMVSSIIDSLEILFNKGETHSAVVDF
EALNVIVRLIEQAPIQMGEEAVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEIASITEQLMTTKLISELQKLFMSKNETYVL
KLWPLFVKLLGRTLHRSGSFINSLLQLEELGFRSGAPMIKKIAFIAWKSLIDNFALNPDILCSAKRLKLLMQPLSSIHVRTETLALTKLE
VWWYLLMRLGPHLPANFEQVCVPLIQSTISIDSNASPQGNSCHVATSPGLNPMTPVHKGASSPYGAPGTPRMNLSSNLGGMATIPSIQLL
GLEMLLHFLLGPEALSFAKQNKLVLSLEPLEHPLISSPSFFSKHANTLITAVHDSFVAVGKDAPDVVVSAIWKELISLVKSVTESGNKKE
KPGSEVLTLLLKSLESIVKSEVFPVSKTLVLMEITIKGLPQKVLGSPAYQVANMDILNGTPALFLIQLIFNNFLECGVSDERFFLSLESL
VGCVLSGPTSPLAFSDSVLNVINQNAKQLENKEHLWKMWSVIVTPLTELINQTNEVNQGDALEHNFSAIYGALTLPVNHIFSEQRFPVAT
MKTLLRTWSELYRAFARCAALVATAEENLCCEELSSKIMSSLEDEGFSNLLFVDRIIYIITVMVDCIDFSPYNIKYQPKVKSPQRPSDWS
KKKNEPLGKLTSLFKLIVKVIYSFHTLSFKEAHSDTLFTIGNSITGIISSVLGHISLPSMIRKIFATLTRPLALFYENSKLDEVPKVYSC
LNNKLEKLLGEIIACLQFSYTGTYDSELLEQLSPLLCIIFLHKNKQIRKQSAQFWNATFAKVMMLVYPEELKPVLTQAKQKFLLLLPGLE
TVEMMEESSGPYSDGTENSQLNVKISGMERKSNGKRDSFLAQTKNKKENMKPAAKLKLESSSLKVKGEILLEEEKSTDFVFIPPEGKDAK
ERILTDHQKEVLKTKRCDIPAMYNNLDVSQDTLFTQYSQEEPMEIPTLTRKPKEDSKMMITAANIPLVSELAIDDIHFDDFSLDVDAMIT
AALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAF
QAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRD
IFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPML

--------------------------------------------------------------
>74084_74084_4_RIF1-PDE11A_RIF1_chr2_152318980_ENST00000428287_PDE11A_chr2_178592900_ENST00000358450_length(transcript)=5779nt_BP=3427nt
ACTCCTGGGCCCGCCCAGCCGCCATCTTGGTCTAGGAGGGAGCGCGCCGCACGCGGTGGCCGACATGACGGCCAGGGGTCAGAGCCCCCT
CGCGCCGCTGTTGGAGACTTTGGAAGACCCTTCTGCCTCCCATGGAGGGCAGACTGACGCTTACCTGACTCTGACCAGTCGTATGACTGG
AGAAGAAGGAAAAGAAGTAATTACAGAAATTGAGAAAAAACTTCCTCGGCTGTACAAAGTTTTAAAGACTCACATTTCCAGTCAAAACTC
GGAGCTGAGTAGTGCTGCTCTACAAGCCCTGGGGTTTTGCTTATATAATCCCAAAATTACCTCAGAATTATCAGAGGCAAATGCTCTAGA
ATTGCTTTCAAAATTGAATGATACCATTAAGAATTCAGACAAAAATGTACGTACTAGAGCACTTTGGGTGATATCTAAGCAGACATTTCC
CTCTGAAGTGGTTGGCAAAATGGTATCCAGTATAATTGATTCATTAGAAATACTGTTTAACAAAGGAGAGACGCATTCTGCTGTTGTTGA
TTTTGAAGCATTAAATGTTATCGTAAGGCTAATTGAACAAGCCCCAATTCAAATGGGAGAAGAGGCAGTGAGGTGGGCAAAACTGGTCAT
ACCTTTAGTGGTTCATTCAGCACAAAAGGTACATTTGCGGGGAGCAACTGCTCTGGAGATGGGAATGCCATTATTGCTTCAGAAACAGCA
AGAAATAGCATCTATTACGGAGCAGCTTATGACTACTAAATTAATCTCAGAACTTCAGAAGCTATTTATGAGTAAAAATGAGACTTACGT
GTTAAAATTATGGCCTTTGTTTGTCAAACTACTTGGAAGGACCTTGCATCGAAGTGGGAGTTTCATCAATTCTCTCTTGCAACTAGAAGA
ACTTGGATTTCGTAGTGGAGCACCCATGATTAAAAAGATAGCTTTTATTGCTTGGAAGAGTTTAATAGATAATTTTGCTTTAAATCCAGA
TATACTATGTAGTGCAAAAAGACTCAAGTTGTTAATGCAGCCTTTGAGTTCCATCCATGTGAGAACAGAAACTCTAGCATTAACAAAACT
AGAAGTCTGGTGGTATTTACTGATGAGACTTGGACCTCATCTTCCTGCTAATTTTGAACAGGTTTGTGTGCCTCTGATTCAAAGTACAAT
AAGCATTGATTCTAATGCCTCACCTCAGGGCAATTCGTGTCATGTAGCTACATCTCCAGGTTTAAATCCTATGACTCCTGTACACAAAGG
TGCTTCCTCCCCGTACGGAGCCCCGGGAACTCCCCGAATGAACCTGAGTTCGAATTTAGGTGGAATGGCCACAATCCCATCCATTCAACT
TTTGGGACTTGAAATGTTGCTTCATTTCTTGTTGGGTCCAGAAGCCTTGAGTTTTGCTAAGCAAAATAAACTTGTGCTGAGCTTAGAGCC
ATTGGAACATCCGTTAATCAGCAGCCCTTCCTTTTTTTCCAAACATGCAAATACACTTATCACTGCTGTTCATGATAGCTTTGTTGCAGT
TGGAAAAGATGCCCCCGATGTGGTTGTCAGTGCTATCTGGAAGGAGCTAATTAGCTTGGTGAAGTCAGTTACTGAATCAGGTAACAAAAA
AGAGAAACCAGGTTCTGAAGTTTTGACTCTCTTATTAAAGTCTTTGGAAAGCATAGTAAAGTCTGAAGTATTTCCTGTATCAAAAACGCT
GGTCCTCATGGAAATTACAATTAAAGGACTTCCTCAGAAAGTATTAGGTTCACCAGCATATCAGGTTGCTAATATGGATATTCTTAATGG
AACTCCAGCTTTGTTCTTAATTCAATTAATTTTCAACAATTTCTTGGAATGTGGTGTATCAGATGAAAGGTTCTTTCTCAGTTTGGAATC
ACTTGTAGGCTGTGTTCTTTCTGGTCCAACTTCACCACTAGCTTTCAGTGACTCAGTTTTAAATGTTATTAATCAAAATGCAAAGCAGTT
GGAAAATAAGGAGCATCTCTGGAAAATGTGGAGTGTTATAGTCACCCCATTAACTGAATTGATTAATCAGACCAATGAAGTAAATCAAGG
TGATGCCTTAGAACATAATTTTAGTGCCATCTATGGTGCATTGACTTTACCAGTAAACCACATTTTTTCAGAACAGAGATTTCCAGTGGC
CACCATGAAGACTTTGCTTAGAACTTGGTCAGAATTATATAGAGCATTTGCTCGTTGTGCTGCTTTGGTGGCAACAGCAGAAGAGAACTT
GTGCTGTGAGGAACTTTCTTCCAAGATAATGTCCAGTTTGGAAGATGAAGGCTTTTCTAATTTGTTGTTCGTGGATAGAATTATTTATAT
TATTACTGTAATGGTTGATTGCATTGACTTCTCACCATATAATATTAAATATCAGCCCAAAGTTAAATCACCACAGAGACCTTCAGATTG
GTCCAAAAAGAAGAATGAGCCCCTAGGGAAATTGACTTCTTTATTTAAACTTATTGTGAAAGTGATCTATTCTTTCCACACACTGAGCTT
CAAGGAAGCACATTCTGATACCCTCTTCACTATTGGCAACTCAATCACCGGCATTATTTCCAGTGTACTTGGGCATATTTCTTTGCCTTC
TATGATCCGAAAAATATTTGCAACTTTAACAAGACCTCTGGCATTATTTTATGAAAACTCAAAGCTTGATGAAGTTCCTAAAGTATATAG
TTGTCTGAACAACAAGTTAGAAAAGCTACTGGGAGAAATTATTGCTTGTCTGCAATTCAGCTACACCGGAACTTATGATAGTGAACTTCT
TGAACAACTCTCCCCACTATTATGCATAATATTTCTGCACAAGAATAAACAGATTCGAAAACAGAGTGCTCAGTTCTGGAATGCCACTTT
TGCCAAAGTGATGATGTTGGTTTATCCTGAAGAGTTAAAACCAGTACTAACACAAGCCAAACAAAAATTTCTGCTCCTGTTGCCTGGTTT
GGAAACTGTTGAAATGATGGAGGAATCCAGTGGACCATATTCTGATGGAACAGAAAATTCACAACTAAATGTGAAGATAAGTGGCATGGA
GAGAAAATCAAATGGAAAAAGAGATTCATTTTTGGCACAAACAAAGAATAAAAAAGAAAATATGAAACCAGCAGCCAAACTGAAACTTGA
ATCTTCGTCTTTAAAAGTAAAGGGTGAAATTCTTTTGGAAGAGGAAAAGTCTACTGACTTTGTGTTTATACCTCCAGAAGGAAAAGATGC
AAAGGAAAGAATATTAACTGATCATCAAAAAGAAGTTCTCAAAACAAAGCGGTGTGATATTCCTGCCATGTATAATAATCTGGATGTTTC
CCAAGATACCTTATTTACTCAGTATAGTCAGGAAGAGCCTATGGAAATTCCTACTTTAACCAGAAAACCAAAGGAGGATTCTAAGATGAT
GATTACGGCAGCCAACATCCCTCTGGTGTCAGAACTTGCCATCGATGACATTCATTTTGATGACTTTTCTCTCGACGTTGATGCCATGAT
CACAGCTGCTCTCCGGATGTTCATGGAGCTGGGGATGGTACAGAAATTTAAAATTGACTATGAGACACTGTGTAGGTGGCTTTTGACAGT
GAGGAAAAACTATCGGATGGTTCTATACCACAACTGGAGACATGCCTTCAACGTGTGTCAGCTGATGTTCGCGATGTTAACCACTGCTGG
GTTTCAAGACATTCTGACCGAGGTGGAAATTTTAGCGGTGATTGTGGGATGCCTGTGTCATGACCTCGACCACAGGGGAACCAACAATGC
CTTCCAAGCTAAGAGTGGCTCTGCCCTGGCCCAACTCTATGGAACCTCTGCTACCTTGGAGCATCACCATTTCAACCACGCCGTGATGAT
CCTTCAAAGTGAGGGTCACAATATCTTTGCTAACCTGTCCTCCAAGGAATATAGTGACCTTATGCAGCTTTTGAAGCAGTCAATATTGGC
AACAGACCTCACGCTGTACTTTGAGAGGAGAACTGAATTCTTTGAACTTGTCAGTAAAGGAGAATACGATTGGAACATCAAAAACCATCG
TGATATATTTCGATCAATGTTAATGACAGCCTGTGACCTTGGAGCCGTGACCAAACCGTGGGAGATCTCCAGACAGGTGGCAGAACTTGT
AACCAGTGAGTTCTTCGAACAAGGAGATCGGGAGAGATTAGAGCTCAAACTCACTCCTTCAGCAATTTTTGATCGGAACCGGAAGGATGA
ACTGCCTCGGTTGCAACTGGAGTGGATTGATAGCATCTGCATGCCTTTGTATCAGGCACTGGTGAAGGTCAACGTGAAACTGAAGCCGAT
GCTAGATTCAGTAGCTACAAACAGAAGTAAGTGGGAAGAGCTACACCAAAAACGACTGCTGGCCTCAACTGCCTCATCCTCCCCTGCCAG
TGTTATGGTAGCCAAGGAAGACAGGAACTAAACCTCCAGGTCAGCTGCAGCTGCAAAATGACTACAGCCTGAAGGGCCATTTTCAGTCCA
GCAATGTCATCCTTTTGTTCTTTTAGCTCAGAAAGACCTAACATCTCAAGGATGCACTGGGAAGCATGCCTGGGCTTTCACCTTGAAGCA
TGGTCAGCAGCAGAGAGAGCAACGGGAAGGACAAAGAAAGAGGTGGGGCAGGGAGCACACCCCAGGACCCTCACTTTTCCCTAATGAACA
CGCATGGGCTGAAATGAAGGCTCTGGGTAGGGGACTGTTTTGGATCCAAGGACCTGTGGACAGTCGGCCTACTTACTCTGAGCTGAGGGA
ACACTGAACAGTAAAAGCGTCATTAGCGCTGCTTCGTTTTGTATAGGGCTTTTCTGTTTGTTACAAGCCAAACACTGCCTGTCTTTGCTT
CCTGTCCCTGAATGCCTTTTTGTGCCAGACTGTCCCAAGAATCCTAATTTGTATTCCATAGAGGTATTTTATTTTTAATCCTAGAGCTTC
TTATTGATGGATCCTTTAGAATTGCCTACCTAAAAGGTAAACTATACTATCCTTATAAATACTGATCAATCCCAGTTCTCCCCCTAAAAA
TGAATACATAGTAGGACTATAGCAAATGTGTTTGATGGGTAATTCTAGACTGGGACTATGGTACCCTTTTCCAGAGTTTTAAAATTCAAC
CTTCATTACAGACAAAGTTTTCTCCCAGAAGGAATGGATTGATAGATTTTGATTAAAGTAAGGGTGGAAGGAAATCTGTAGCTGGATTTA
CCACAAGTGACATCTAGAAACTATAGTTCACAGGACAGAGCAGAGCCATGGAGACTAAGCATTGACTACCTTGAGTTCTCCTAGTGAGGA
GTTCTGGTATAAAATTTAAGATTACTACCAGTAACCAACTTAAAGCAAACTATAGGGGTCCCTAATTTTGGATTTTTCCTTAAGTGTAAG
AAACAATGCTTCAAATGTTAAGAAATAACAGTCTGGGCAAAGAACGCATATTCTATAGGAAGCCAGGTTTACAATAGGTAAGAATAAACT
GTATTAAGTAGATGTAATGACTAGAAAGCTGCTTTGCTCCCTATATTGAGAAATTGTGGACATGGTATGTGTTATCCAAAGAACATTGGG
CTAGAAGATAGATTTCTATCCTTAGCTTTGGCATTATTGACTGGATTGACTTGAACAAGTCACTTAACTTCTACAAGCTTGTTTCCTTAT
TTGTCAAATTAGATTACACTAGGAAACGATTCTCGAACATGTTTTAACCTTACAACTCTTTGTTCAAATAAATCTTTCAATGAATCCCCA

>74084_74084_4_RIF1-PDE11A_RIF1_chr2_152318980_ENST00000428287_PDE11A_chr2_178592900_ENST00000358450_length(amino acids)=1478AA_BP=1141
MGPPSRHLGLGGSAPHAVADMTARGQSPLAPLLETLEDPSASHGGQTDAYLTLTSRMTGEEGKEVITEIEKKLPRLYKVLKTHISSQNSE
LSSAALQALGFCLYNPKITSELSEANALELLSKLNDTIKNSDKNVRTRALWVISKQTFPSEVVGKMVSSIIDSLEILFNKGETHSAVVDF
EALNVIVRLIEQAPIQMGEEAVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEIASITEQLMTTKLISELQKLFMSKNETYVL
KLWPLFVKLLGRTLHRSGSFINSLLQLEELGFRSGAPMIKKIAFIAWKSLIDNFALNPDILCSAKRLKLLMQPLSSIHVRTETLALTKLE
VWWYLLMRLGPHLPANFEQVCVPLIQSTISIDSNASPQGNSCHVATSPGLNPMTPVHKGASSPYGAPGTPRMNLSSNLGGMATIPSIQLL
GLEMLLHFLLGPEALSFAKQNKLVLSLEPLEHPLISSPSFFSKHANTLITAVHDSFVAVGKDAPDVVVSAIWKELISLVKSVTESGNKKE
KPGSEVLTLLLKSLESIVKSEVFPVSKTLVLMEITIKGLPQKVLGSPAYQVANMDILNGTPALFLIQLIFNNFLECGVSDERFFLSLESL
VGCVLSGPTSPLAFSDSVLNVINQNAKQLENKEHLWKMWSVIVTPLTELINQTNEVNQGDALEHNFSAIYGALTLPVNHIFSEQRFPVAT
MKTLLRTWSELYRAFARCAALVATAEENLCCEELSSKIMSSLEDEGFSNLLFVDRIIYIITVMVDCIDFSPYNIKYQPKVKSPQRPSDWS
KKKNEPLGKLTSLFKLIVKVIYSFHTLSFKEAHSDTLFTIGNSITGIISSVLGHISLPSMIRKIFATLTRPLALFYENSKLDEVPKVYSC
LNNKLEKLLGEIIACLQFSYTGTYDSELLEQLSPLLCIIFLHKNKQIRKQSAQFWNATFAKVMMLVYPEELKPVLTQAKQKFLLLLPGLE
TVEMMEESSGPYSDGTENSQLNVKISGMERKSNGKRDSFLAQTKNKKENMKPAAKLKLESSSLKVKGEILLEEEKSTDFVFIPPEGKDAK
ERILTDHQKEVLKTKRCDIPAMYNNLDVSQDTLFTQYSQEEPMEIPTLTRKPKEDSKMMITAANIPLVSELAIDDIHFDDFSLDVDAMIT
AALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAF
QAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRD
IFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPML

--------------------------------------------------------------
>74084_74084_5_RIF1-PDE11A_RIF1_chr2_152318980_ENST00000430328_PDE11A_chr2_178592900_ENST00000286063_length(transcript)=10866nt_BP=3697nt
CCCTCCGCCCCCTCGCGGCGAGATGCCTCGTTCCCCGGGCTTCTCCCGCCCTCCGCCGATCTCCTCCCTCTGTTGAAAGCTGCCCGGGAA
AGTGGTGGCGGGAGCGGGCCCAGGCCCGAATGTGGCGTGGGCTCAGGTGTCTGGTGTCGGGCGCCGGAGGAGGTTCGCGCTGGGGTTTGG
TGATTCGGAGGCCTGGGGTGCAGACGCGGCGTGGCTGTGAGGCCCGGGCGGGCGTGCGGGTGTGAGGGCCGGACTCACACTGGGCCGCCG
CGGGGCTGTTTCCATCGGTCACTGGATTTTCTCCTCTTCCGGTTCGGGCCTCAGGGTGGCCGACATGACGGCCAGGGGTCAGAGCCCCCT
CGCGCCGCTGTTGGAGACTTTGGAAGACCCTTCTGCCTCCCATGGAGGGCAGACTGACGCTTACCTGACTCTGACCAGTCGTATGACTGG
AGAAGAAGGAAAAGAAGTAATTACAGAAATTGAGAAAAAACTTCCTCGGCTGTACAAAGTTTTAAAGACTCACATTTCCAGTCAAAACTC
GGAGCTGAGTAGTGCTGCTCTACAAGCCCTGGGGTTTTGCTTATATAATCCCAAAATTACCTCAGAATTATCAGAGGCAAATGCTCTAGA
ATTGCTTTCAAAATTGAATGATACCATTAAGAATTCAGACAAAAATGTACGTACTAGAGCACTTTGGGTGATATCTAAGCAGACATTTCC
CTCTGAAGTGGTTGGCAAAATGGTATCCAGTATAATTGATTCATTAGAAATACTGTTTAACAAAGGAGAGACGCATTCTGCTGTTGTTGA
TTTTGAAGCATTAAATGTTATCGTAAGGCTAATTGAACAAGCCCCAATTCAAATGGGAGAAGAGGCAGTGAGGTGGGCAAAACTGGTCAT
ACCTTTAGTGGTTCATTCAGCACAAAAGGTACATTTGCGGGGAGCAACTGCTCTGGAGATGGGAATGCCATTATTGCTTCAGAAACAGCA
AGAAATAGCATCTATTACGGAGCAGCTTATGACTACTAAATTAATCTCAGAACTTCAGAAGCTATTTATGAGTAAAAATGAGACTTACGT
GTTAAAATTATGGCCTTTGTTTGTCAAACTACTTGGAAGGACCTTGCATCGAAGTGGGAGTTTCATCAATTCTCTCTTGCAACTAGAAGA
ACTTGGATTTCGTAGTGGAGCACCCATGATTAAAAAGATAGCTTTTATTGCTTGGAAGAGTTTAATAGATAATTTTGCTTTAAATCCAGA
TATACTATGTAGTGCAAAAAGACTCAAGTTGTTAATGCAGCCTTTGAGTTCCATCCATGTGAGAACAGAAACTCTAGCATTAACAAAACT
AGAAGTCTGGTGGTATTTACTGATGAGACTTGGACCTCATCTTCCTGCTAATTTTGAACAGGTTTGTGTGCCTCTGATTCAAAGTACAAT
AAGCATTGATTCTAATGCCTCACCTCAGGGCAATTCGTGTCATGTAGCTACATCTCCAGGTTTAAATCCTATGACTCCTGTACACAAAGG
TGCTTCCTCCCCGTACGGAGCCCCGGGAACTCCCCGAATGAACCTGAGTTCGAATTTAGGTGGAATGGCCACAATCCCATCCATTCAACT
TTTGGGACTTGAAATGTTGCTTCATTTCTTGTTGGGTCCAGAAGCCTTGAGTTTTGCTAAGCAAAATAAACTTGTGCTGAGCTTAGAGCC
ATTGGAACATCCGTTAATCAGCAGCCCTTCCTTTTTTTCCAAACATGCAAATACACTTATCACTGCTGTTCATGATAGCTTTGTTGCAGT
TGGAAAAGATGCCCCCGATGTGGTTGTCAGTGCTATCTGGAAGGAGCTAATTAGCTTGGTGAAGTCAGTTACTGAATCAGGTAACAAAAA
AGAGAAACCAGGTTCTGAAGTTTTGACTCTCTTATTAAAGTCTTTGGAAAGCATAGTAAAGTCTGAAGTATTTCCTGTATCAAAAACGCT
GGTCCTCATGGAAATTACAATTAAAGGACTTCCTCAGAAAGTATTAGGTTCACCAGCATATCAGGTTGCTAATATGGATATTCTTAATGG
AACTCCAGCTTTGTTCTTAATTCAATTAATTTTCAACAATTTCTTGGAATGTGGTGTATCAGATGAAAGGTTCTTTCTCAGTTTGGAATC
ACTTGTAGGCTGTGTTCTTTCTGGTCCAACTTCACCACTAGCTTTCAGTGACTCAGTTTTAAATGTTATTAATCAAAATGCAAAGCAGTT
GGAAAATAAGGAGCATCTCTGGAAAATGTGGAGTGTTATAGTCACCCCATTAACTGAATTGATTAATCAGACCAATGAAGTAAATCAAGG
TGATGCCTTAGAACATAATTTTAGTGCCATCTATGGTGCATTGACTTTACCAGTAAACCACATTTTTTCAGAACAGAGATTTCCAGTGGC
CACCATGAAGACTTTGCTTAGAACTTGGTCAGAATTATATAGAGCATTTGCTCGTTGTGCTGCTTTGGTGGCAACAGCAGAAGAGAACTT
GTGCTGTGAGGAACTTTCTTCCAAGATAATGTCCAGTTTGGAAGATGAAGGCTTTTCTAATTTGTTGTTCGTGGATAGAATTATTTATAT
TATTACTGTAATGGTTGATTGCATTGACTTCTCACCATATAATATTAAATATCAGCCCAAAGTTAAATCACCACAGAGACCTTCAGATTG
GTCCAAAAAGAAGAATGAGCCCCTAGGGAAATTGACTTCTTTATTTAAACTTATTGTGAAAGTGATCTATTCTTTCCACACACTGAGCTT
CAAGGAAGCACATTCTGATACCCTCTTCACTATTGGCAACTCAATCACCGGCATTATTTCCAGTGTACTTGGGCATATTTCTTTGCCTTC
TATGATCCGAAAAATATTTGCAACTTTAACAAGACCTCTGGCATTATTTTATGAAAACTCAAAGCTTGATGAAGTTCCTAAAGTATATAG
TTGTCTGAACAACAAGTTAGAAAAGCTACTGGGAGAAATTATTGCTTGTCTGCAATTCAGCTACACCGGAACTTATGATAGTGAACTTCT
TGAACAACTCTCCCCACTATTATGCATAATATTTCTGCACAAGAATAAACAGATTCGAAAACAGAGTGCTCAGTTCTGGAATGCCACTTT
TGCCAAAGTGATGATGTTGGTTTATCCTGAAGAGTTAAAACCAGTACTAACACAAGCCAAACAAAAATTTCTGCTCCTGTTGCCTGGTTT
GGAAACTGTTGAAATGATGGAGGAATCCAGTGGACCATATTCTGATGGAACAGAAAATTCACAACTAAATGTGAAGATAAGTGGCATGGA
GAGAAAATCAAATGGAAAAAGAGATTCATTTTTGGCACAAACAAAGAATAAAAAAGAAAATATGAAACCAGCAGCCAAACTGAAACTTGA
ATCTTCGTCTTTAAAAGTAAAGGGTGAAATTCTTTTGGAAGAGGAAAAGTCTACTGACTTTGTGTTTATACCTCCAGAAGGAAAAGATGC
AAAGGAAAGAATATTAACTGATCATCAAAAAGAAGTTCTCAAAACAAAGCGGTGTGATATTCCTGCCATGTATAATAATCTGGATGTTTC
CCAAGATACCTTATTTACTCAGTATAGTCAGGAAGAGCCTATGGAAATTCCTACTTTAACCAGAAAACCAAAGGAGGATTCTAAGATGAT
GATTACGGCAGCCAACATCCCTCTGGTGTCAGAACTTGCCATCGATGACATTCATTTTGATGACTTTTCTCTCGACGTTGATGCCATGAT
CACAGCTGCTCTCCGGATGTTCATGGAGCTGGGGATGGTACAGAAATTTAAAATTGACTATGAGACACTGTGTAGGTGGCTTTTGACAGT
GAGGAAAAACTATCGGATGGTTCTATACCACAACTGGAGACATGCCTTCAACGTGTGTCAGCTGATGTTCGCGATGTTAACCACTGCTGG
GTTTCAAGACATTCTGACCGAGGTGGAAATTTTAGCGGTGATTGTGGGATGCCTGTGTCATGACCTCGACCACAGGGGAACCAACAATGC
CTTCCAAGCTAAGAGTGGCTCTGCCCTGGCCCAACTCTATGGAACCTCTGCTACCTTGGAGCATCACCATTTCAACCACGCCGTGATGAT
CCTTCAAAGTGAGGGTCACAATATCTTTGCTAACCTGTCCTCCAAGGAATATAGTGACCTTATGCAGCTTTTGAAGCAGTCAATATTGGC
AACAGACCTCACGCTGTACTTTGAGAGGAGAACTGAATTCTTTGAACTTGTCAGTAAAGGAGAATACGATTGGAACATCAAAAACCATCG
TGATATATTTCGATCAATGTTAATGACAGCCTGTGACCTTGGAGCCGTGACCAAACCGTGGGAGATCTCCAGACAGGTGGCAGAACTTGT
AACCAGTGAGTTCTTCGAACAAGGAGATCGGGAGAGATTAGAGCTCAAACTCACTCCTTCAGCAATTTTTGATCGGAACCGGAAGGATGA
ACTGCCTCGGTTGCAACTGGAGTGGATTGATAGCATCTGCATGCCTTTGTATCAGGCACTGGTGAAGGTCAACGTGAAACTGAAGCCGAT
GCTAGATTCAGTAGCTACAAACAGAAGTAAGTGGGAAGAGCTACACCAAAAACGACTGCTGGCCTCAACTGCCTCATCCTCCCCTGCCAG
TGTTATGGTAGCCAAGGAAGACAGGAACTAAACCTCCAGGTCAGCTGCAGCTGCAAAATGACTACAGCCTGAAGGGCCATTTTCAGTCCA
GCAATGTCATCCTTTTGTTCTTTTAGCTCAGAAAGACCTAACATCTCAAGGATGCACTGGGAAGCATGCCTGGGCTTTCACCTTGAAGCA
TGGTCAGCAGCAGAGAGAGCAACGGGAAGGACAAAGAAAGAGGTGGGGCAGGGAGCACACCCCAGGACCCTCACTTTTCCCTAATGAACA
CGCATGGGCTGAAATGAAGGCTCTGGGTAGGGGACTGTTTTGGATCCAAGGACCTGTGGACAGTCGGCCTACTTACTCTGAGCTGAGGGA
ACACTGAACAGTAAAAGCGTCATTAGCGCTGCTTCGTTTTGTATAGGGCTTTTCTGTTTGTTACAAGCCAAACACTGCCTGTCTTTGCTT
CCTGTCCCTGAATGCCTTTTTGTGCCAGACTGTCCCAAGAATCCTAATTTGTATTCCATAGAGGTATTTTATTTTTAATCCTAGAGCTTC
TTATTGATGGATCCTTTAGAATTGCCTACCTAAAAGGTAAACTATACTATCCTTATAAATACTGATCAATCCCAGTTCTCCCCCTAAAAA
TGAATACATAGTAGGACTATAGCAAATGTGTTTGATGGGTAATTCTAGACTGGGACTATGGTACCCTTTTCCAGAGTTTTAAAATTCAAC
CTTCATTACAGACAAAGTTTTCTCCCAGAAGGAATGGATTGATAGATTTTGATTAAAGTAAGGGTGGAAGGAAATCTGTAGCTGGATTTA
CCACAAGTGACATCTAGAAACTATAGTTCACAGGACAGAGCAGAGCCATGGAGACTAAGCATTGACTACCTTGAGTTCTCCTAGTGAGGA
GTTCTGGTATAAAATTTAAGATTACTACCAGTAACCAACTTAAAGCAAACTATAGGGGTCCCTAATTTTGGATTTTTCCTTAAGTGTAAG
AAACAATGCTTCAAATGTTAAGAAATAACAGTCTGGGCAAAGAACGCATATTCTATAGGAAGCCAGGTTTACAATAGGTAAGAATAAACT
GTATTAAGTAGATGTAATGACTAGAAAGCTGCTTTGCTCCCTATATTGAGAAATTGTGGACATGGTATGTGTTATCCAAAGAACATTGGG
CTAGAAGATAGATTTCTATCCTTAGCTTTGGCATTATTGACTGGATTGACTTGAACAAGTCACTTAACTTCTACAAGCTTGTTTCCTTAT
TTGTCAAATTAGATTACACTAGGAAACGATTCTCGAACATGTTTTAACCTTACAACTCTTTGTTCAAATAAATCTTTCAATGAATCCCCA
ACATATAAAACGTCAAAAAGCTGAATTCCTATGTGAATTATAAGCAGGGTTTGGACATCCAGAGCACCTACAAACCTTCATCTCTTTGAT
TACGTACATGGGGGTCCACAGGGACTCTGAAGAGTTTGAAAATCCCTGGCCTAGATTAAACCTGAGAGCCATTCTAGCTCTTAAAAAAAT
CTGAAATTTACAAACCATTTTTCTTGTTATTGTTTTTGTTTCTTTGTTTGTTTGTTTTTTGAGACTGAGTTTTCACTCTTGTTGCCCAGG
CTGGAGTGCAATGGCGTGATCTCGGCTTACTGCAACCTCTGCTTCCTGGGTTCAAGCAATTCTCCAGCCTCAACCTCCTGAGAAGCTGGG
ATTACAGGTGCCTGCCACCACGCCTGGCTAATTTTTGTACTTTTAGTAGACACAGGGTTTCACCATGTTTGCCAGGCTGATCTCAAACTC
CTGACCTCAGGTGAGCCACCCACCTCTGCCTCCGAAAGTGCTGGGATTACAGGCGTGAGCCACCGTACCCGGCCCTTGTTATTGTTATTA
ATCATTATCAATCATTAACTTTACAGATATTAAAGAAATAGGGGCCATGTTCTACATGCGACATTGTTTTCCTGGCACACAGTAGACAAT
TCAGGAAATGTCTGAAGAAGGAATGGGTAAAATTAAGATACCAAAATGGAATTGAGGGGAGAGCAGGTAATTGTAGAGAAAAAGACTCTT
TATGGCAAGAAACAAAGTAAAAGAAATGTATAGACCGGGCGCGGTGGCTCACGCCTGTAATCCCAGCAATTTGGAAGGCCGAGGCGGGCG
GATCACGAGGTCAGGAGATCGAGACCGTCCTGGCTAACACGGTGAAACCCTGTCTCTACTAAAAAACACAAAACAAATTAGCCAGGCGCG
GTGGCAGGCGTCTGTAGTCCCAGCTACTGGGGAGGCTGAGGCAAGAGAATGGCGGGAACCCGCGAGGCGGAGCTTGCAGTGAGTCGAGAT
CACGTCACTGCCCTCCAGCCTGGGCGACCAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGTATAAACCA
GACTAAGAGGGGAATAAAAGCAAGAAGAAAAAGAAACGTAAGAACACCAGTAAAGGAAAGACAGGGACCGAGACAGGTGGTTAAGGGAAA
TGAAAAAAAAAAAAAAAAGGTGAAAGTCAATCCAAACAAAGAAAAATGGCACTTCCAACCAAAAAAAATGAAGGTGTAGAACCCTGTCAT
CAATTGCTCAGAAAAGAGAGACACTTGAGCAGGGAGGGGTTTGAGAAAGGGGAGAAGGAAGGAGTGAGAGCCCTAAAAAATAATGTTCCT
AGCTACCCTTTACAGCTGTCTCTGCAGGGAAGACTGGAGAAAGTAGAGGGGGAAATGAATGCAGGAAGAAACTGCCTCTGCAGAGCAGGT
AAGAGGAGGTTGTTCAGATTTATGGATTTTATTAAGCCAGTTTTCTGTATCACTCTGCTATAAAGGAAAATAGCTTCTGCAGGGCTGTCT
CTCCTCCTTCAGGTGGGGAACAAAGGGTGGGTGGAGTCAGGGACAGAGTCTGGTCTGCGAGATCGTGACGTGTCTGCAGCTCCGAAGCAC
TGCAGGTGTTTCTGGGTAATGTGCCACATCATGTTTATATCACGAACGGGAATTGAAAATCAGTCTGTGTGAGGCAGAGATGAGCCCACA
TCTGTTATCCTCCCCAACAATAAATAAATAAATAGCCCAGACAAATGGATGCCAGTCCATCTACAGCAACATTTTAAAGCATGTGCTTTA
TGACAAAACTGGACCCAGGGTCTGACAGAGACTGCAGGCTGCCGTGAGCACTGTAGCTATCCTGAACATTGATGCTACATATTGCTAAGG
GGAACATAATTTATAGCATAAACCCTACAAGCTTCCACTAAGGTTGAGTTTTCCTCTCATTTTCTTGCCGTTTTATTGGCTTCACTGCAT
GGTTGCCAATAGCAACATCCACTGGTAGCAAGGGGAGTTCAACACCATTGCAATCTGCCATACAGTGGAGCCCTGACAATGTCAACCATC
AATCTAGTAGCTGTTTGTAATTGCCTCCATCTATTTCTCCTGTCTTGAGGTATCTTTCCTATTGTGGGTCAAGATTTAGAAACTGCTGAC
TAATGCCATGGGTCTGTGTCTCCATGACTATGAAGCAGTGGACAGGAAGGTAGCAGCTTCCTGGTGCCAACAACCCCAGAGGTTAGAGGT
TGAACTCTTGCGGGTTTCAGGCGTTTTTAATCCCTTTTCTAAACAATTTATAATTTTGCAAGAATGTGAGGCATATGCAGTTATCCATAT
AATCTGCTTTTCCAAAAAAGAGAAAGGAAGTTTCCCAGTCCTTATTATTAATGTTTATTTCCTATTGGAGAAAGACATTTGAAATATGAG
CCTTCTTGTAAAAACTCAAACTGACCAGATTATGTTTGCTTCCTCAGGTCTCTTGGCATTAATTGTTGAAATAACTTCATCCTACTTTTT
CGATGAGATGTATTTTTTTCAGACATATTTATTCTTACTAGTCACTATGTAGCTATTATGTGCACAATCTACAATGTAGTGGCAATCCTG
GTGGGTAGGGACAGCTTCACATACTGCAAAGGGTGCCATTCAGTGCATAGCAGACTGGAACTCCCTCCTAGCTTGGCCACCAGCTGAACC
TGTAATCTTAGGACTCTCCAAGTCTTAGAATCTCCATCTATTACATAAAAGCACTGACTTTTATTCAGTCCCCACACCAAAGGACCAAGA
CGTGTTTAGCTTTAAAGAAATTTTCCAGATAATTTTCTTTTTTATTCTTCTCAAATAAAATAGCAACAAACCTAAAGCAGTCATCTTCTT
AATAAAGACATAATAAAACTTACATATATGGGGTAGATGTAAGCACAATCATACTACAGATGTATCTTGAGCCTGTCTCTAATTATGATG
AAAGATGTAGTCATCAATACAATTTAAAAAAAGATATGTCCTTTTTTTGAGACAGGGTCTTGCTCTGTCACCCAGGCTGGAGGGCAGTGG
CACAATCACAGCCACTGCAGCCTTGACCTCTCCAACTTAAGTGATCTTTCCTGCCTCAGCCTCATGAGTAGCTGGGACCACAGGTGTGCA
CCACCACACCCAGCTAAATTTTGTATTGTTTGTAAAGACGAGGCCTCACTATGCTGACCACACTGGTCTCGAACTCCTGGGCTCAAGCAA
TCCTCCTGCCTTGGCCTCCCAAAGTGTTAGGGTTAGAGATATGAACCACCACACCCACCTTATATGTCCTTTTATTTCATAAAAAACAAT
TTTAGATTATCTGATATCACACATATCCCATAAATGGTAGTCATTAATTTAGAAGTGAATTTATAAAGTTAAGAGAAGTTAAAATTGCAC
ATGCATTTTGTTTCTAAAATCTGAGATGTCTATGCATTTCCAGGTATTGTATATTTGCAAATACATTGGGTTAGAAATCATCTTTAACAT
TTTGTGTTAGTGTAATAACAATATTATCTAATATTAATGCTGCCAGAATCCAGTTGCTTTTTCTGTGTATCAAAATTTATCATAACTTTT
TCCACTTAACACTAGGTAATTAAACAGAATCTGCCCAATTTATTCTGCAGTAAAATTATTTTAAAATCTATTTTTCCTGCTGACTCTTAG
AAATTGCAGAAAGACAAAAACCAGTTTCATCTCCAGTAATAGTGTGAAACAATTTCCTTCCAGTGGGACAGAAACCTAGACATACTAGGG
AAAGATTTAAATATAAAGAAAAATGCCTTGGCTGAAAAAAAAAAAAACCACCAAAACACAAAAAGGATTCATTAAAGCAACAGAACAAAA
CCTAATTTGGGACCCTAAAAACTCTGGCAATGCCACTGTAATGAAGTTTCATTATCTGCTTCAGAGTAACAGTCTCTGAAATTGTTATTC
TGCTACATGCTGTAAAGAACTCCCAAAACTCAAATGTATCAGGAAATGTAAAGGTTAAGTCTGACTACAAGAAGGCCAAAATTGCACCAG
CTTCCTAAGTGAAGAATAATAGAATAAAACATATAGAGGGCAGAAATAAAATGAGGTGTATCTGGAGAATTTCATGATGAGCATTTAGAT
TTAGCAATGCCCAATGTCATGCTGACACTGTTTGTCATGACCTTGTCTTCAGCTAGTAATTTGGGGTTGTACTTTTTTAAATTTAATTTT
GAATGTTCTTGCATGTTTGGTACCTCTCTCCTCACTGCTAAAGATAAATTGTTTATCTGTATAACATAACTACACCAATGTCATTTTTGT
ATACGCTAGTACACAAATGTGTTTTTTTATTAAGTAATGAAGTATTTGCTGTGAAAAATGTATTATTTGTGCCACCGTTTATATCTGTGT
TCATTTTCTGTGTGTATATGCGTGTGTATTCGAATCTCAATTTTTCTTTTACTCTAGTTTAGATTAAGACATATTTAGATGAAATTTTAA
AAATAACATTGGAAATAGGAGGCTAAGTTTTGTTGAGTCTCATTCCCTTGGGGGGAAATTGCTTTTGCCATTTTATTTTCATGTACAATA
ACCTAAAAAGGATCTCCTACTGACTTCCTTCCTAATTATTATTGTTTTACACGAAAGAAAGGAAATACGTTTTCAATTGAGTTGTTTGAA
ATCATTCACTTTGTGTAGATTTCCCAGACTGATGTTTCATTGTAAGAATATTACATTATAGACAGGTTGGCCATTTCACAAGCAACTAAT

>74084_74084_5_RIF1-PDE11A_RIF1_chr2_152318980_ENST00000430328_PDE11A_chr2_178592900_ENST00000286063_length(amino acids)=1483AA_BP=1146
MGRRGAVSIGHWIFSSSGSGLRVADMTARGQSPLAPLLETLEDPSASHGGQTDAYLTLTSRMTGEEGKEVITEIEKKLPRLYKVLKTHIS
SQNSELSSAALQALGFCLYNPKITSELSEANALELLSKLNDTIKNSDKNVRTRALWVISKQTFPSEVVGKMVSSIIDSLEILFNKGETHS
AVVDFEALNVIVRLIEQAPIQMGEEAVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEIASITEQLMTTKLISELQKLFMSKN
ETYVLKLWPLFVKLLGRTLHRSGSFINSLLQLEELGFRSGAPMIKKIAFIAWKSLIDNFALNPDILCSAKRLKLLMQPLSSIHVRTETLA
LTKLEVWWYLLMRLGPHLPANFEQVCVPLIQSTISIDSNASPQGNSCHVATSPGLNPMTPVHKGASSPYGAPGTPRMNLSSNLGGMATIP
SIQLLGLEMLLHFLLGPEALSFAKQNKLVLSLEPLEHPLISSPSFFSKHANTLITAVHDSFVAVGKDAPDVVVSAIWKELISLVKSVTES
GNKKEKPGSEVLTLLLKSLESIVKSEVFPVSKTLVLMEITIKGLPQKVLGSPAYQVANMDILNGTPALFLIQLIFNNFLECGVSDERFFL
SLESLVGCVLSGPTSPLAFSDSVLNVINQNAKQLENKEHLWKMWSVIVTPLTELINQTNEVNQGDALEHNFSAIYGALTLPVNHIFSEQR
FPVATMKTLLRTWSELYRAFARCAALVATAEENLCCEELSSKIMSSLEDEGFSNLLFVDRIIYIITVMVDCIDFSPYNIKYQPKVKSPQR
PSDWSKKKNEPLGKLTSLFKLIVKVIYSFHTLSFKEAHSDTLFTIGNSITGIISSVLGHISLPSMIRKIFATLTRPLALFYENSKLDEVP
KVYSCLNNKLEKLLGEIIACLQFSYTGTYDSELLEQLSPLLCIIFLHKNKQIRKQSAQFWNATFAKVMMLVYPEELKPVLTQAKQKFLLL
LPGLETVEMMEESSGPYSDGTENSQLNVKISGMERKSNGKRDSFLAQTKNKKENMKPAAKLKLESSSLKVKGEILLEEEKSTDFVFIPPE
GKDAKERILTDHQKEVLKTKRCDIPAMYNNLDVSQDTLFTQYSQEEPMEIPTLTRKPKEDSKMMITAANIPLVSELAIDDIHFDDFSLDV
DAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRG
TNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNI
KNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVK

--------------------------------------------------------------
>74084_74084_6_RIF1-PDE11A_RIF1_chr2_152318980_ENST00000430328_PDE11A_chr2_178592900_ENST00000358450_length(transcript)=6049nt_BP=3697nt
CCCTCCGCCCCCTCGCGGCGAGATGCCTCGTTCCCCGGGCTTCTCCCGCCCTCCGCCGATCTCCTCCCTCTGTTGAAAGCTGCCCGGGAA
AGTGGTGGCGGGAGCGGGCCCAGGCCCGAATGTGGCGTGGGCTCAGGTGTCTGGTGTCGGGCGCCGGAGGAGGTTCGCGCTGGGGTTTGG
TGATTCGGAGGCCTGGGGTGCAGACGCGGCGTGGCTGTGAGGCCCGGGCGGGCGTGCGGGTGTGAGGGCCGGACTCACACTGGGCCGCCG
CGGGGCTGTTTCCATCGGTCACTGGATTTTCTCCTCTTCCGGTTCGGGCCTCAGGGTGGCCGACATGACGGCCAGGGGTCAGAGCCCCCT
CGCGCCGCTGTTGGAGACTTTGGAAGACCCTTCTGCCTCCCATGGAGGGCAGACTGACGCTTACCTGACTCTGACCAGTCGTATGACTGG
AGAAGAAGGAAAAGAAGTAATTACAGAAATTGAGAAAAAACTTCCTCGGCTGTACAAAGTTTTAAAGACTCACATTTCCAGTCAAAACTC
GGAGCTGAGTAGTGCTGCTCTACAAGCCCTGGGGTTTTGCTTATATAATCCCAAAATTACCTCAGAATTATCAGAGGCAAATGCTCTAGA
ATTGCTTTCAAAATTGAATGATACCATTAAGAATTCAGACAAAAATGTACGTACTAGAGCACTTTGGGTGATATCTAAGCAGACATTTCC
CTCTGAAGTGGTTGGCAAAATGGTATCCAGTATAATTGATTCATTAGAAATACTGTTTAACAAAGGAGAGACGCATTCTGCTGTTGTTGA
TTTTGAAGCATTAAATGTTATCGTAAGGCTAATTGAACAAGCCCCAATTCAAATGGGAGAAGAGGCAGTGAGGTGGGCAAAACTGGTCAT
ACCTTTAGTGGTTCATTCAGCACAAAAGGTACATTTGCGGGGAGCAACTGCTCTGGAGATGGGAATGCCATTATTGCTTCAGAAACAGCA
AGAAATAGCATCTATTACGGAGCAGCTTATGACTACTAAATTAATCTCAGAACTTCAGAAGCTATTTATGAGTAAAAATGAGACTTACGT
GTTAAAATTATGGCCTTTGTTTGTCAAACTACTTGGAAGGACCTTGCATCGAAGTGGGAGTTTCATCAATTCTCTCTTGCAACTAGAAGA
ACTTGGATTTCGTAGTGGAGCACCCATGATTAAAAAGATAGCTTTTATTGCTTGGAAGAGTTTAATAGATAATTTTGCTTTAAATCCAGA
TATACTATGTAGTGCAAAAAGACTCAAGTTGTTAATGCAGCCTTTGAGTTCCATCCATGTGAGAACAGAAACTCTAGCATTAACAAAACT
AGAAGTCTGGTGGTATTTACTGATGAGACTTGGACCTCATCTTCCTGCTAATTTTGAACAGGTTTGTGTGCCTCTGATTCAAAGTACAAT
AAGCATTGATTCTAATGCCTCACCTCAGGGCAATTCGTGTCATGTAGCTACATCTCCAGGTTTAAATCCTATGACTCCTGTACACAAAGG
TGCTTCCTCCCCGTACGGAGCCCCGGGAACTCCCCGAATGAACCTGAGTTCGAATTTAGGTGGAATGGCCACAATCCCATCCATTCAACT
TTTGGGACTTGAAATGTTGCTTCATTTCTTGTTGGGTCCAGAAGCCTTGAGTTTTGCTAAGCAAAATAAACTTGTGCTGAGCTTAGAGCC
ATTGGAACATCCGTTAATCAGCAGCCCTTCCTTTTTTTCCAAACATGCAAATACACTTATCACTGCTGTTCATGATAGCTTTGTTGCAGT
TGGAAAAGATGCCCCCGATGTGGTTGTCAGTGCTATCTGGAAGGAGCTAATTAGCTTGGTGAAGTCAGTTACTGAATCAGGTAACAAAAA
AGAGAAACCAGGTTCTGAAGTTTTGACTCTCTTATTAAAGTCTTTGGAAAGCATAGTAAAGTCTGAAGTATTTCCTGTATCAAAAACGCT
GGTCCTCATGGAAATTACAATTAAAGGACTTCCTCAGAAAGTATTAGGTTCACCAGCATATCAGGTTGCTAATATGGATATTCTTAATGG
AACTCCAGCTTTGTTCTTAATTCAATTAATTTTCAACAATTTCTTGGAATGTGGTGTATCAGATGAAAGGTTCTTTCTCAGTTTGGAATC
ACTTGTAGGCTGTGTTCTTTCTGGTCCAACTTCACCACTAGCTTTCAGTGACTCAGTTTTAAATGTTATTAATCAAAATGCAAAGCAGTT
GGAAAATAAGGAGCATCTCTGGAAAATGTGGAGTGTTATAGTCACCCCATTAACTGAATTGATTAATCAGACCAATGAAGTAAATCAAGG
TGATGCCTTAGAACATAATTTTAGTGCCATCTATGGTGCATTGACTTTACCAGTAAACCACATTTTTTCAGAACAGAGATTTCCAGTGGC
CACCATGAAGACTTTGCTTAGAACTTGGTCAGAATTATATAGAGCATTTGCTCGTTGTGCTGCTTTGGTGGCAACAGCAGAAGAGAACTT
GTGCTGTGAGGAACTTTCTTCCAAGATAATGTCCAGTTTGGAAGATGAAGGCTTTTCTAATTTGTTGTTCGTGGATAGAATTATTTATAT
TATTACTGTAATGGTTGATTGCATTGACTTCTCACCATATAATATTAAATATCAGCCCAAAGTTAAATCACCACAGAGACCTTCAGATTG
GTCCAAAAAGAAGAATGAGCCCCTAGGGAAATTGACTTCTTTATTTAAACTTATTGTGAAAGTGATCTATTCTTTCCACACACTGAGCTT
CAAGGAAGCACATTCTGATACCCTCTTCACTATTGGCAACTCAATCACCGGCATTATTTCCAGTGTACTTGGGCATATTTCTTTGCCTTC
TATGATCCGAAAAATATTTGCAACTTTAACAAGACCTCTGGCATTATTTTATGAAAACTCAAAGCTTGATGAAGTTCCTAAAGTATATAG
TTGTCTGAACAACAAGTTAGAAAAGCTACTGGGAGAAATTATTGCTTGTCTGCAATTCAGCTACACCGGAACTTATGATAGTGAACTTCT
TGAACAACTCTCCCCACTATTATGCATAATATTTCTGCACAAGAATAAACAGATTCGAAAACAGAGTGCTCAGTTCTGGAATGCCACTTT
TGCCAAAGTGATGATGTTGGTTTATCCTGAAGAGTTAAAACCAGTACTAACACAAGCCAAACAAAAATTTCTGCTCCTGTTGCCTGGTTT
GGAAACTGTTGAAATGATGGAGGAATCCAGTGGACCATATTCTGATGGAACAGAAAATTCACAACTAAATGTGAAGATAAGTGGCATGGA
GAGAAAATCAAATGGAAAAAGAGATTCATTTTTGGCACAAACAAAGAATAAAAAAGAAAATATGAAACCAGCAGCCAAACTGAAACTTGA
ATCTTCGTCTTTAAAAGTAAAGGGTGAAATTCTTTTGGAAGAGGAAAAGTCTACTGACTTTGTGTTTATACCTCCAGAAGGAAAAGATGC
AAAGGAAAGAATATTAACTGATCATCAAAAAGAAGTTCTCAAAACAAAGCGGTGTGATATTCCTGCCATGTATAATAATCTGGATGTTTC
CCAAGATACCTTATTTACTCAGTATAGTCAGGAAGAGCCTATGGAAATTCCTACTTTAACCAGAAAACCAAAGGAGGATTCTAAGATGAT
GATTACGGCAGCCAACATCCCTCTGGTGTCAGAACTTGCCATCGATGACATTCATTTTGATGACTTTTCTCTCGACGTTGATGCCATGAT
CACAGCTGCTCTCCGGATGTTCATGGAGCTGGGGATGGTACAGAAATTTAAAATTGACTATGAGACACTGTGTAGGTGGCTTTTGACAGT
GAGGAAAAACTATCGGATGGTTCTATACCACAACTGGAGACATGCCTTCAACGTGTGTCAGCTGATGTTCGCGATGTTAACCACTGCTGG
GTTTCAAGACATTCTGACCGAGGTGGAAATTTTAGCGGTGATTGTGGGATGCCTGTGTCATGACCTCGACCACAGGGGAACCAACAATGC
CTTCCAAGCTAAGAGTGGCTCTGCCCTGGCCCAACTCTATGGAACCTCTGCTACCTTGGAGCATCACCATTTCAACCACGCCGTGATGAT
CCTTCAAAGTGAGGGTCACAATATCTTTGCTAACCTGTCCTCCAAGGAATATAGTGACCTTATGCAGCTTTTGAAGCAGTCAATATTGGC
AACAGACCTCACGCTGTACTTTGAGAGGAGAACTGAATTCTTTGAACTTGTCAGTAAAGGAGAATACGATTGGAACATCAAAAACCATCG
TGATATATTTCGATCAATGTTAATGACAGCCTGTGACCTTGGAGCCGTGACCAAACCGTGGGAGATCTCCAGACAGGTGGCAGAACTTGT
AACCAGTGAGTTCTTCGAACAAGGAGATCGGGAGAGATTAGAGCTCAAACTCACTCCTTCAGCAATTTTTGATCGGAACCGGAAGGATGA
ACTGCCTCGGTTGCAACTGGAGTGGATTGATAGCATCTGCATGCCTTTGTATCAGGCACTGGTGAAGGTCAACGTGAAACTGAAGCCGAT
GCTAGATTCAGTAGCTACAAACAGAAGTAAGTGGGAAGAGCTACACCAAAAACGACTGCTGGCCTCAACTGCCTCATCCTCCCCTGCCAG
TGTTATGGTAGCCAAGGAAGACAGGAACTAAACCTCCAGGTCAGCTGCAGCTGCAAAATGACTACAGCCTGAAGGGCCATTTTCAGTCCA
GCAATGTCATCCTTTTGTTCTTTTAGCTCAGAAAGACCTAACATCTCAAGGATGCACTGGGAAGCATGCCTGGGCTTTCACCTTGAAGCA
TGGTCAGCAGCAGAGAGAGCAACGGGAAGGACAAAGAAAGAGGTGGGGCAGGGAGCACACCCCAGGACCCTCACTTTTCCCTAATGAACA
CGCATGGGCTGAAATGAAGGCTCTGGGTAGGGGACTGTTTTGGATCCAAGGACCTGTGGACAGTCGGCCTACTTACTCTGAGCTGAGGGA
ACACTGAACAGTAAAAGCGTCATTAGCGCTGCTTCGTTTTGTATAGGGCTTTTCTGTTTGTTACAAGCCAAACACTGCCTGTCTTTGCTT
CCTGTCCCTGAATGCCTTTTTGTGCCAGACTGTCCCAAGAATCCTAATTTGTATTCCATAGAGGTATTTTATTTTTAATCCTAGAGCTTC
TTATTGATGGATCCTTTAGAATTGCCTACCTAAAAGGTAAACTATACTATCCTTATAAATACTGATCAATCCCAGTTCTCCCCCTAAAAA
TGAATACATAGTAGGACTATAGCAAATGTGTTTGATGGGTAATTCTAGACTGGGACTATGGTACCCTTTTCCAGAGTTTTAAAATTCAAC
CTTCATTACAGACAAAGTTTTCTCCCAGAAGGAATGGATTGATAGATTTTGATTAAAGTAAGGGTGGAAGGAAATCTGTAGCTGGATTTA
CCACAAGTGACATCTAGAAACTATAGTTCACAGGACAGAGCAGAGCCATGGAGACTAAGCATTGACTACCTTGAGTTCTCCTAGTGAGGA
GTTCTGGTATAAAATTTAAGATTACTACCAGTAACCAACTTAAAGCAAACTATAGGGGTCCCTAATTTTGGATTTTTCCTTAAGTGTAAG
AAACAATGCTTCAAATGTTAAGAAATAACAGTCTGGGCAAAGAACGCATATTCTATAGGAAGCCAGGTTTACAATAGGTAAGAATAAACT
GTATTAAGTAGATGTAATGACTAGAAAGCTGCTTTGCTCCCTATATTGAGAAATTGTGGACATGGTATGTGTTATCCAAAGAACATTGGG
CTAGAAGATAGATTTCTATCCTTAGCTTTGGCATTATTGACTGGATTGACTTGAACAAGTCACTTAACTTCTACAAGCTTGTTTCCTTAT
TTGTCAAATTAGATTACACTAGGAAACGATTCTCGAACATGTTTTAACCTTACAACTCTTTGTTCAAATAAATCTTTCAATGAATCCCCA

>74084_74084_6_RIF1-PDE11A_RIF1_chr2_152318980_ENST00000430328_PDE11A_chr2_178592900_ENST00000358450_length(amino acids)=1483AA_BP=1146
MGRRGAVSIGHWIFSSSGSGLRVADMTARGQSPLAPLLETLEDPSASHGGQTDAYLTLTSRMTGEEGKEVITEIEKKLPRLYKVLKTHIS
SQNSELSSAALQALGFCLYNPKITSELSEANALELLSKLNDTIKNSDKNVRTRALWVISKQTFPSEVVGKMVSSIIDSLEILFNKGETHS
AVVDFEALNVIVRLIEQAPIQMGEEAVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEIASITEQLMTTKLISELQKLFMSKN
ETYVLKLWPLFVKLLGRTLHRSGSFINSLLQLEELGFRSGAPMIKKIAFIAWKSLIDNFALNPDILCSAKRLKLLMQPLSSIHVRTETLA
LTKLEVWWYLLMRLGPHLPANFEQVCVPLIQSTISIDSNASPQGNSCHVATSPGLNPMTPVHKGASSPYGAPGTPRMNLSSNLGGMATIP
SIQLLGLEMLLHFLLGPEALSFAKQNKLVLSLEPLEHPLISSPSFFSKHANTLITAVHDSFVAVGKDAPDVVVSAIWKELISLVKSVTES
GNKKEKPGSEVLTLLLKSLESIVKSEVFPVSKTLVLMEITIKGLPQKVLGSPAYQVANMDILNGTPALFLIQLIFNNFLECGVSDERFFL
SLESLVGCVLSGPTSPLAFSDSVLNVINQNAKQLENKEHLWKMWSVIVTPLTELINQTNEVNQGDALEHNFSAIYGALTLPVNHIFSEQR
FPVATMKTLLRTWSELYRAFARCAALVATAEENLCCEELSSKIMSSLEDEGFSNLLFVDRIIYIITVMVDCIDFSPYNIKYQPKVKSPQR
PSDWSKKKNEPLGKLTSLFKLIVKVIYSFHTLSFKEAHSDTLFTIGNSITGIISSVLGHISLPSMIRKIFATLTRPLALFYENSKLDEVP
KVYSCLNNKLEKLLGEIIACLQFSYTGTYDSELLEQLSPLLCIIFLHKNKQIRKQSAQFWNATFAKVMMLVYPEELKPVLTQAKQKFLLL
LPGLETVEMMEESSGPYSDGTENSQLNVKISGMERKSNGKRDSFLAQTKNKKENMKPAAKLKLESSSLKVKGEILLEEEKSTDFVFIPPE
GKDAKERILTDHQKEVLKTKRCDIPAMYNNLDVSQDTLFTQYSQEEPMEIPTLTRKPKEDSKMMITAANIPLVSELAIDDIHFDDFSLDV
DAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRG
TNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNI
KNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVK

--------------------------------------------------------------
>74084_74084_7_RIF1-PDE11A_RIF1_chr2_152318980_ENST00000444746_PDE11A_chr2_178592900_ENST00000286063_length(transcript)=10693nt_BP=3524nt
CGCACTCCTGGGCCCGCCCAGCCGCCATCTTGGTCTAGGAGGGAGCGCGCCGCACGCGTGAGTAAACAGCCGGAGCTGGGAAAGTCGAGC
TCTGGCAGCGTCTGGGTGCTGAGGGGCAGAGGCGGAGAGAACCCTGTCCTGATCTTCCTAGGGTGGCCGACATGACGGCCAGGGGTCAGA
GCCCCCTCGCGCCGCTGTTGGAGACTTTGGAAGACCCTTCTGCCTCCCATGGAGGGCAGACTGACGCTTACCTGACTCTGACCAGTCGTA
TGACTGGAGAAGAAGGAAAAGAAGTAATTACAGAAATTGAGAAAAAACTTCCTCGGCTGTACAAAGTTTTAAAGACTCACATTTCCAGTC
AAAACTCGGAGCTGAGTAGTGCTGCTCTACAAGCCCTGGGGTTTTGCTTATATAATCCCAAAATTACCTCAGAATTATCAGAGGCAAATG
CTCTAGAATTGCTTTCAAAATTGAATGATACCATTAAGAATTCAGACAAAAATGTACGTACTAGAGCACTTTGGGTGATATCTAAGCAGA
CATTTCCCTCTGAAGTGGTTGGCAAAATGGTATCCAGTATAATTGATTCATTAGAAATACTGTTTAACAAAGGAGAGACGCATTCTGCTG
TTGTTGATTTTGAAGCATTAAATGTTATCGTAAGGCTAATTGAACAAGCCCCAATTCAAATGGGAGAAGAGGCAGTGAGGTGGGCAAAAC
TGGTCATACCTTTAGTGGTTCATTCAGCACAAAAGGTACATTTGCGGGGAGCAACTGCTCTGGAGATGGGAATGCCATTATTGCTTCAGA
AACAGCAAGAAATAGCATCTATTACGGAGCAGCTTATGACTACTAAATTAATCTCAGAACTTCAGAAGCTATTTATGAGTAAAAATGAGA
CTTACGTGTTAAAATTATGGCCTTTGTTTGTCAAACTACTTGGAAGGACCTTGCATCGAAGTGGGAGTTTCATCAATTCTCTCTTGCAAC
TAGAAGAACTTGGATTTCGTAGTGGAGCACCCATGATTAAAAAGATAGCTTTTATTGCTTGGAAGAGTTTAATAGATAATTTTGCTTTAA
ATCCAGATATACTATGTAGTGCAAAAAGACTCAAGTTGTTAATGCAGCCTTTGAGTTCCATCCATGTGAGAACAGAAACTCTAGCATTAA
CAAAACTAGAAGTCTGGTGGTATTTACTGATGAGACTTGGACCTCATCTTCCTGCTAATTTTGAACAGGTTTGTGTGCCTCTGATTCAAA
GTACAATAAGCATTGATTCTAATGCCTCACCTCAGGGCAATTCGTGTCATGTAGCTACATCTCCAGGTTTAAATCCTATGACTCCTGTAC
ACAAAGGTGCTTCCTCCCCGTACGGAGCCCCGGGAACTCCCCGAATGAACCTGAGTTCGAATTTAGGTGGAATGGCCACAATCCCATCCA
TTCAACTTTTGGGACTTGAAATGTTGCTTCATTTCTTGTTGGGTCCAGAAGCCTTGAGTTTTGCTAAGCAAAATAAACTTGTGCTGAGCT
TAGAGCCATTGGAACATCCGTTAATCAGCAGCCCTTCCTTTTTTTCCAAACATGCAAATACACTTATCACTGCTGTTCATGATAGCTTTG
TTGCAGTTGGAAAAGATGCCCCCGATGTGGTTGTCAGTGCTATCTGGAAGGAGCTAATTAGCTTGGTGAAGTCAGTTACTGAATCAGGTA
ACAAAAAAGAGAAACCAGGTTCTGAAGTTTTGACTCTCTTATTAAAGTCTTTGGAAAGCATAGTAAAGTCTGAAGTATTTCCTGTATCAA
AAACGCTGGTCCTCATGGAAATTACAATTAAAGGACTTCCTCAGAAAGTATTAGGTTCACCAGCATATCAGGTTGCTAATATGGATATTC
TTAATGGAACTCCAGCTTTGTTCTTAATTCAATTAATTTTCAACAATTTCTTGGAATGTGGTGTATCAGATGAAAGGTTCTTTCTCAGTT
TGGAATCACTTGTAGGCTGTGTTCTTTCTGGTCCAACTTCACCACTAGCTTTCAGTGACTCAGTTTTAAATGTTATTAATCAAAATGCAA
AGCAGTTGGAAAATAAGGAGCATCTCTGGAAAATGTGGAGTGTTATAGTCACCCCATTAACTGAATTGATTAATCAGACCAATGAAGTAA
ATCAAGGTGATGCCTTAGAACATAATTTTAGTGCCATCTATGGTGCATTGACTTTACCAGTAAACCACATTTTTTCAGAACAGAGATTTC
CAGTGGCCACCATGAAGACTTTGCTTAGAACTTGGTCAGAATTATATAGAGCATTTGCTCGTTGTGCTGCTTTGGTGGCAACAGCAGAAG
AGAACTTGTGCTGTGAGGAACTTTCTTCCAAGATAATGTCCAGTTTGGAAGATGAAGGCTTTTCTAATTTGTTGTTCGTGGATAGAATTA
TTTATATTATTACTGTAATGGTTGATTGCATTGACTTCTCACCATATAATATTAAATATCAGCCCAAAGTTAAATCACCACAGAGACCTT
CAGATTGGTCCAAAAAGAAGAATGAGCCCCTAGGGAAATTGACTTCTTTATTTAAACTTATTGTGAAAGTGATCTATTCTTTCCACACAC
TGAGCTTCAAGGAAGCACATTCTGATACCCTCTTCACTATTGGCAACTCAATCACCGGCATTATTTCCAGTGTACTTGGGCATATTTCTT
TGCCTTCTATGATCCGAAAAATATTTGCAACTTTAACAAGACCTCTGGCATTATTTTATGAAAACTCAAAGCTTGATGAAGTTCCTAAAG
TATATAGTTGTCTGAACAACAAGTTAGAAAAGCTACTGGGAGAAATTATTGCTTGTCTGCAATTCAGCTACACCGGAACTTATGATAGTG
AACTTCTTGAACAACTCTCCCCACTATTATGCATAATATTTCTGCACAAGAATAAACAGATTCGAAAACAGAGTGCTCAGTTCTGGAATG
CCACTTTTGCCAAAGTGATGATGTTGGTTTATCCTGAAGAGTTAAAACCAGTACTAACACAAGCCAAACAAAAATTTCTGCTCCTGTTGC
CTGGTTTGGAAACTGTTGAAATGATGGAGGAATCCAGTGGACCATATTCTGATGGAACAGAAAATTCACAACTAAATGTGAAGATAAGTG
GCATGGAGAGAAAATCAAATGGAAAAAGAGATTCATTTTTGGCACAAACAAAGAATAAAAAAGAAAATATGAAACCAGCAGCCAAACTGA
AACTTGAATCTTCGTCTTTAAAAGTAAAGGGTGAAATTCTTTTGGAAGAGGAAAAGTCTACTGACTTTGTGTTTATACCTCCAGAAGGAA
AAGATGCAAAGGAAAGAATATTAACTGATCATCAAAAAGAAGTTCTCAAAACAAAGCGGTGTGATATTCCTGCCATGTATAATAATCTGG
ATGTTTCCCAAGATACCTTATTTACTCAGTATAGTCAGGAAGAGCCTATGGAAATTCCTACTTTAACCAGAAAACCAAAGGAGGATTCTA
AGATGATGATTACGGCAGCCAACATCCCTCTGGTGTCAGAACTTGCCATCGATGACATTCATTTTGATGACTTTTCTCTCGACGTTGATG
CCATGATCACAGCTGCTCTCCGGATGTTCATGGAGCTGGGGATGGTACAGAAATTTAAAATTGACTATGAGACACTGTGTAGGTGGCTTT
TGACAGTGAGGAAAAACTATCGGATGGTTCTATACCACAACTGGAGACATGCCTTCAACGTGTGTCAGCTGATGTTCGCGATGTTAACCA
CTGCTGGGTTTCAAGACATTCTGACCGAGGTGGAAATTTTAGCGGTGATTGTGGGATGCCTGTGTCATGACCTCGACCACAGGGGAACCA
ACAATGCCTTCCAAGCTAAGAGTGGCTCTGCCCTGGCCCAACTCTATGGAACCTCTGCTACCTTGGAGCATCACCATTTCAACCACGCCG
TGATGATCCTTCAAAGTGAGGGTCACAATATCTTTGCTAACCTGTCCTCCAAGGAATATAGTGACCTTATGCAGCTTTTGAAGCAGTCAA
TATTGGCAACAGACCTCACGCTGTACTTTGAGAGGAGAACTGAATTCTTTGAACTTGTCAGTAAAGGAGAATACGATTGGAACATCAAAA
ACCATCGTGATATATTTCGATCAATGTTAATGACAGCCTGTGACCTTGGAGCCGTGACCAAACCGTGGGAGATCTCCAGACAGGTGGCAG
AACTTGTAACCAGTGAGTTCTTCGAACAAGGAGATCGGGAGAGATTAGAGCTCAAACTCACTCCTTCAGCAATTTTTGATCGGAACCGGA
AGGATGAACTGCCTCGGTTGCAACTGGAGTGGATTGATAGCATCTGCATGCCTTTGTATCAGGCACTGGTGAAGGTCAACGTGAAACTGA
AGCCGATGCTAGATTCAGTAGCTACAAACAGAAGTAAGTGGGAAGAGCTACACCAAAAACGACTGCTGGCCTCAACTGCCTCATCCTCCC
CTGCCAGTGTTATGGTAGCCAAGGAAGACAGGAACTAAACCTCCAGGTCAGCTGCAGCTGCAAAATGACTACAGCCTGAAGGGCCATTTT
CAGTCCAGCAATGTCATCCTTTTGTTCTTTTAGCTCAGAAAGACCTAACATCTCAAGGATGCACTGGGAAGCATGCCTGGGCTTTCACCT
TGAAGCATGGTCAGCAGCAGAGAGAGCAACGGGAAGGACAAAGAAAGAGGTGGGGCAGGGAGCACACCCCAGGACCCTCACTTTTCCCTA
ATGAACACGCATGGGCTGAAATGAAGGCTCTGGGTAGGGGACTGTTTTGGATCCAAGGACCTGTGGACAGTCGGCCTACTTACTCTGAGC
TGAGGGAACACTGAACAGTAAAAGCGTCATTAGCGCTGCTTCGTTTTGTATAGGGCTTTTCTGTTTGTTACAAGCCAAACACTGCCTGTC
TTTGCTTCCTGTCCCTGAATGCCTTTTTGTGCCAGACTGTCCCAAGAATCCTAATTTGTATTCCATAGAGGTATTTTATTTTTAATCCTA
GAGCTTCTTATTGATGGATCCTTTAGAATTGCCTACCTAAAAGGTAAACTATACTATCCTTATAAATACTGATCAATCCCAGTTCTCCCC
CTAAAAATGAATACATAGTAGGACTATAGCAAATGTGTTTGATGGGTAATTCTAGACTGGGACTATGGTACCCTTTTCCAGAGTTTTAAA
ATTCAACCTTCATTACAGACAAAGTTTTCTCCCAGAAGGAATGGATTGATAGATTTTGATTAAAGTAAGGGTGGAAGGAAATCTGTAGCT
GGATTTACCACAAGTGACATCTAGAAACTATAGTTCACAGGACAGAGCAGAGCCATGGAGACTAAGCATTGACTACCTTGAGTTCTCCTA
GTGAGGAGTTCTGGTATAAAATTTAAGATTACTACCAGTAACCAACTTAAAGCAAACTATAGGGGTCCCTAATTTTGGATTTTTCCTTAA
GTGTAAGAAACAATGCTTCAAATGTTAAGAAATAACAGTCTGGGCAAAGAACGCATATTCTATAGGAAGCCAGGTTTACAATAGGTAAGA
ATAAACTGTATTAAGTAGATGTAATGACTAGAAAGCTGCTTTGCTCCCTATATTGAGAAATTGTGGACATGGTATGTGTTATCCAAAGAA
CATTGGGCTAGAAGATAGATTTCTATCCTTAGCTTTGGCATTATTGACTGGATTGACTTGAACAAGTCACTTAACTTCTACAAGCTTGTT
TCCTTATTTGTCAAATTAGATTACACTAGGAAACGATTCTCGAACATGTTTTAACCTTACAACTCTTTGTTCAAATAAATCTTTCAATGA
ATCCCCAACATATAAAACGTCAAAAAGCTGAATTCCTATGTGAATTATAAGCAGGGTTTGGACATCCAGAGCACCTACAAACCTTCATCT
CTTTGATTACGTACATGGGGGTCCACAGGGACTCTGAAGAGTTTGAAAATCCCTGGCCTAGATTAAACCTGAGAGCCATTCTAGCTCTTA
AAAAAATCTGAAATTTACAAACCATTTTTCTTGTTATTGTTTTTGTTTCTTTGTTTGTTTGTTTTTTGAGACTGAGTTTTCACTCTTGTT
GCCCAGGCTGGAGTGCAATGGCGTGATCTCGGCTTACTGCAACCTCTGCTTCCTGGGTTCAAGCAATTCTCCAGCCTCAACCTCCTGAGA
AGCTGGGATTACAGGTGCCTGCCACCACGCCTGGCTAATTTTTGTACTTTTAGTAGACACAGGGTTTCACCATGTTTGCCAGGCTGATCT
CAAACTCCTGACCTCAGGTGAGCCACCCACCTCTGCCTCCGAAAGTGCTGGGATTACAGGCGTGAGCCACCGTACCCGGCCCTTGTTATT
GTTATTAATCATTATCAATCATTAACTTTACAGATATTAAAGAAATAGGGGCCATGTTCTACATGCGACATTGTTTTCCTGGCACACAGT
AGACAATTCAGGAAATGTCTGAAGAAGGAATGGGTAAAATTAAGATACCAAAATGGAATTGAGGGGAGAGCAGGTAATTGTAGAGAAAAA
GACTCTTTATGGCAAGAAACAAAGTAAAAGAAATGTATAGACCGGGCGCGGTGGCTCACGCCTGTAATCCCAGCAATTTGGAAGGCCGAG
GCGGGCGGATCACGAGGTCAGGAGATCGAGACCGTCCTGGCTAACACGGTGAAACCCTGTCTCTACTAAAAAACACAAAACAAATTAGCC
AGGCGCGGTGGCAGGCGTCTGTAGTCCCAGCTACTGGGGAGGCTGAGGCAAGAGAATGGCGGGAACCCGCGAGGCGGAGCTTGCAGTGAG
TCGAGATCACGTCACTGCCCTCCAGCCTGGGCGACCAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGTA
TAAACCAGACTAAGAGGGGAATAAAAGCAAGAAGAAAAAGAAACGTAAGAACACCAGTAAAGGAAAGACAGGGACCGAGACAGGTGGTTA
AGGGAAATGAAAAAAAAAAAAAAAAGGTGAAAGTCAATCCAAACAAAGAAAAATGGCACTTCCAACCAAAAAAAATGAAGGTGTAGAACC
CTGTCATCAATTGCTCAGAAAAGAGAGACACTTGAGCAGGGAGGGGTTTGAGAAAGGGGAGAAGGAAGGAGTGAGAGCCCTAAAAAATAA
TGTTCCTAGCTACCCTTTACAGCTGTCTCTGCAGGGAAGACTGGAGAAAGTAGAGGGGGAAATGAATGCAGGAAGAAACTGCCTCTGCAG
AGCAGGTAAGAGGAGGTTGTTCAGATTTATGGATTTTATTAAGCCAGTTTTCTGTATCACTCTGCTATAAAGGAAAATAGCTTCTGCAGG
GCTGTCTCTCCTCCTTCAGGTGGGGAACAAAGGGTGGGTGGAGTCAGGGACAGAGTCTGGTCTGCGAGATCGTGACGTGTCTGCAGCTCC
GAAGCACTGCAGGTGTTTCTGGGTAATGTGCCACATCATGTTTATATCACGAACGGGAATTGAAAATCAGTCTGTGTGAGGCAGAGATGA
GCCCACATCTGTTATCCTCCCCAACAATAAATAAATAAATAGCCCAGACAAATGGATGCCAGTCCATCTACAGCAACATTTTAAAGCATG
TGCTTTATGACAAAACTGGACCCAGGGTCTGACAGAGACTGCAGGCTGCCGTGAGCACTGTAGCTATCCTGAACATTGATGCTACATATT
GCTAAGGGGAACATAATTTATAGCATAAACCCTACAAGCTTCCACTAAGGTTGAGTTTTCCTCTCATTTTCTTGCCGTTTTATTGGCTTC
ACTGCATGGTTGCCAATAGCAACATCCACTGGTAGCAAGGGGAGTTCAACACCATTGCAATCTGCCATACAGTGGAGCCCTGACAATGTC
AACCATCAATCTAGTAGCTGTTTGTAATTGCCTCCATCTATTTCTCCTGTCTTGAGGTATCTTTCCTATTGTGGGTCAAGATTTAGAAAC
TGCTGACTAATGCCATGGGTCTGTGTCTCCATGACTATGAAGCAGTGGACAGGAAGGTAGCAGCTTCCTGGTGCCAACAACCCCAGAGGT
TAGAGGTTGAACTCTTGCGGGTTTCAGGCGTTTTTAATCCCTTTTCTAAACAATTTATAATTTTGCAAGAATGTGAGGCATATGCAGTTA
TCCATATAATCTGCTTTTCCAAAAAAGAGAAAGGAAGTTTCCCAGTCCTTATTATTAATGTTTATTTCCTATTGGAGAAAGACATTTGAA
ATATGAGCCTTCTTGTAAAAACTCAAACTGACCAGATTATGTTTGCTTCCTCAGGTCTCTTGGCATTAATTGTTGAAATAACTTCATCCT
ACTTTTTCGATGAGATGTATTTTTTTCAGACATATTTATTCTTACTAGTCACTATGTAGCTATTATGTGCACAATCTACAATGTAGTGGC
AATCCTGGTGGGTAGGGACAGCTTCACATACTGCAAAGGGTGCCATTCAGTGCATAGCAGACTGGAACTCCCTCCTAGCTTGGCCACCAG
CTGAACCTGTAATCTTAGGACTCTCCAAGTCTTAGAATCTCCATCTATTACATAAAAGCACTGACTTTTATTCAGTCCCCACACCAAAGG
ACCAAGACGTGTTTAGCTTTAAAGAAATTTTCCAGATAATTTTCTTTTTTATTCTTCTCAAATAAAATAGCAACAAACCTAAAGCAGTCA
TCTTCTTAATAAAGACATAATAAAACTTACATATATGGGGTAGATGTAAGCACAATCATACTACAGATGTATCTTGAGCCTGTCTCTAAT
TATGATGAAAGATGTAGTCATCAATACAATTTAAAAAAAGATATGTCCTTTTTTTGAGACAGGGTCTTGCTCTGTCACCCAGGCTGGAGG
GCAGTGGCACAATCACAGCCACTGCAGCCTTGACCTCTCCAACTTAAGTGATCTTTCCTGCCTCAGCCTCATGAGTAGCTGGGACCACAG
GTGTGCACCACCACACCCAGCTAAATTTTGTATTGTTTGTAAAGACGAGGCCTCACTATGCTGACCACACTGGTCTCGAACTCCTGGGCT
CAAGCAATCCTCCTGCCTTGGCCTCCCAAAGTGTTAGGGTTAGAGATATGAACCACCACACCCACCTTATATGTCCTTTTATTTCATAAA
AAACAATTTTAGATTATCTGATATCACACATATCCCATAAATGGTAGTCATTAATTTAGAAGTGAATTTATAAAGTTAAGAGAAGTTAAA
ATTGCACATGCATTTTGTTTCTAAAATCTGAGATGTCTATGCATTTCCAGGTATTGTATATTTGCAAATACATTGGGTTAGAAATCATCT
TTAACATTTTGTGTTAGTGTAATAACAATATTATCTAATATTAATGCTGCCAGAATCCAGTTGCTTTTTCTGTGTATCAAAATTTATCAT
AACTTTTTCCACTTAACACTAGGTAATTAAACAGAATCTGCCCAATTTATTCTGCAGTAAAATTATTTTAAAATCTATTTTTCCTGCTGA
CTCTTAGAAATTGCAGAAAGACAAAAACCAGTTTCATCTCCAGTAATAGTGTGAAACAATTTCCTTCCAGTGGGACAGAAACCTAGACAT
ACTAGGGAAAGATTTAAATATAAAGAAAAATGCCTTGGCTGAAAAAAAAAAAAACCACCAAAACACAAAAAGGATTCATTAAAGCAACAG
AACAAAACCTAATTTGGGACCCTAAAAACTCTGGCAATGCCACTGTAATGAAGTTTCATTATCTGCTTCAGAGTAACAGTCTCTGAAATT
GTTATTCTGCTACATGCTGTAAAGAACTCCCAAAACTCAAATGTATCAGGAAATGTAAAGGTTAAGTCTGACTACAAGAAGGCCAAAATT
GCACCAGCTTCCTAAGTGAAGAATAATAGAATAAAACATATAGAGGGCAGAAATAAAATGAGGTGTATCTGGAGAATTTCATGATGAGCA
TTTAGATTTAGCAATGCCCAATGTCATGCTGACACTGTTTGTCATGACCTTGTCTTCAGCTAGTAATTTGGGGTTGTACTTTTTTAAATT
TAATTTTGAATGTTCTTGCATGTTTGGTACCTCTCTCCTCACTGCTAAAGATAAATTGTTTATCTGTATAACATAACTACACCAATGTCA
TTTTTGTATACGCTAGTACACAAATGTGTTTTTTTATTAAGTAATGAAGTATTTGCTGTGAAAAATGTATTATTTGTGCCACCGTTTATA
TCTGTGTTCATTTTCTGTGTGTATATGCGTGTGTATTCGAATCTCAATTTTTCTTTTACTCTAGTTTAGATTAAGACATATTTAGATGAA
ATTTTAAAAATAACATTGGAAATAGGAGGCTAAGTTTTGTTGAGTCTCATTCCCTTGGGGGGAAATTGCTTTTGCCATTTTATTTTCATG
TACAATAACCTAAAAAGGATCTCCTACTGACTTCCTTCCTAATTATTATTGTTTTACACGAAAGAAAGGAAATACGTTTTCAATTGAGTT
GTTTGAAATCATTCACTTTGTGTAGATTTCCCAGACTGATGTTTCATTGTAAGAATATTACATTATAGACAGGTTGGCCATTTCACAAGC

>74084_74084_7_RIF1-PDE11A_RIF1_chr2_152318980_ENST00000444746_PDE11A_chr2_178592900_ENST00000286063_length(amino acids)=1478AA_BP=1141
MGAEGQRRREPCPDLPRVADMTARGQSPLAPLLETLEDPSASHGGQTDAYLTLTSRMTGEEGKEVITEIEKKLPRLYKVLKTHISSQNSE
LSSAALQALGFCLYNPKITSELSEANALELLSKLNDTIKNSDKNVRTRALWVISKQTFPSEVVGKMVSSIIDSLEILFNKGETHSAVVDF
EALNVIVRLIEQAPIQMGEEAVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEIASITEQLMTTKLISELQKLFMSKNETYVL
KLWPLFVKLLGRTLHRSGSFINSLLQLEELGFRSGAPMIKKIAFIAWKSLIDNFALNPDILCSAKRLKLLMQPLSSIHVRTETLALTKLE
VWWYLLMRLGPHLPANFEQVCVPLIQSTISIDSNASPQGNSCHVATSPGLNPMTPVHKGASSPYGAPGTPRMNLSSNLGGMATIPSIQLL
GLEMLLHFLLGPEALSFAKQNKLVLSLEPLEHPLISSPSFFSKHANTLITAVHDSFVAVGKDAPDVVVSAIWKELISLVKSVTESGNKKE
KPGSEVLTLLLKSLESIVKSEVFPVSKTLVLMEITIKGLPQKVLGSPAYQVANMDILNGTPALFLIQLIFNNFLECGVSDERFFLSLESL
VGCVLSGPTSPLAFSDSVLNVINQNAKQLENKEHLWKMWSVIVTPLTELINQTNEVNQGDALEHNFSAIYGALTLPVNHIFSEQRFPVAT
MKTLLRTWSELYRAFARCAALVATAEENLCCEELSSKIMSSLEDEGFSNLLFVDRIIYIITVMVDCIDFSPYNIKYQPKVKSPQRPSDWS
KKKNEPLGKLTSLFKLIVKVIYSFHTLSFKEAHSDTLFTIGNSITGIISSVLGHISLPSMIRKIFATLTRPLALFYENSKLDEVPKVYSC
LNNKLEKLLGEIIACLQFSYTGTYDSELLEQLSPLLCIIFLHKNKQIRKQSAQFWNATFAKVMMLVYPEELKPVLTQAKQKFLLLLPGLE
TVEMMEESSGPYSDGTENSQLNVKISGMERKSNGKRDSFLAQTKNKKENMKPAAKLKLESSSLKVKGEILLEEEKSTDFVFIPPEGKDAK
ERILTDHQKEVLKTKRCDIPAMYNNLDVSQDTLFTQYSQEEPMEIPTLTRKPKEDSKMMITAANIPLVSELAIDDIHFDDFSLDVDAMIT
AALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAF
QAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRD
IFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPML

--------------------------------------------------------------
>74084_74084_8_RIF1-PDE11A_RIF1_chr2_152318980_ENST00000444746_PDE11A_chr2_178592900_ENST00000358450_length(transcript)=5876nt_BP=3524nt
CGCACTCCTGGGCCCGCCCAGCCGCCATCTTGGTCTAGGAGGGAGCGCGCCGCACGCGTGAGTAAACAGCCGGAGCTGGGAAAGTCGAGC
TCTGGCAGCGTCTGGGTGCTGAGGGGCAGAGGCGGAGAGAACCCTGTCCTGATCTTCCTAGGGTGGCCGACATGACGGCCAGGGGTCAGA
GCCCCCTCGCGCCGCTGTTGGAGACTTTGGAAGACCCTTCTGCCTCCCATGGAGGGCAGACTGACGCTTACCTGACTCTGACCAGTCGTA
TGACTGGAGAAGAAGGAAAAGAAGTAATTACAGAAATTGAGAAAAAACTTCCTCGGCTGTACAAAGTTTTAAAGACTCACATTTCCAGTC
AAAACTCGGAGCTGAGTAGTGCTGCTCTACAAGCCCTGGGGTTTTGCTTATATAATCCCAAAATTACCTCAGAATTATCAGAGGCAAATG
CTCTAGAATTGCTTTCAAAATTGAATGATACCATTAAGAATTCAGACAAAAATGTACGTACTAGAGCACTTTGGGTGATATCTAAGCAGA
CATTTCCCTCTGAAGTGGTTGGCAAAATGGTATCCAGTATAATTGATTCATTAGAAATACTGTTTAACAAAGGAGAGACGCATTCTGCTG
TTGTTGATTTTGAAGCATTAAATGTTATCGTAAGGCTAATTGAACAAGCCCCAATTCAAATGGGAGAAGAGGCAGTGAGGTGGGCAAAAC
TGGTCATACCTTTAGTGGTTCATTCAGCACAAAAGGTACATTTGCGGGGAGCAACTGCTCTGGAGATGGGAATGCCATTATTGCTTCAGA
AACAGCAAGAAATAGCATCTATTACGGAGCAGCTTATGACTACTAAATTAATCTCAGAACTTCAGAAGCTATTTATGAGTAAAAATGAGA
CTTACGTGTTAAAATTATGGCCTTTGTTTGTCAAACTACTTGGAAGGACCTTGCATCGAAGTGGGAGTTTCATCAATTCTCTCTTGCAAC
TAGAAGAACTTGGATTTCGTAGTGGAGCACCCATGATTAAAAAGATAGCTTTTATTGCTTGGAAGAGTTTAATAGATAATTTTGCTTTAA
ATCCAGATATACTATGTAGTGCAAAAAGACTCAAGTTGTTAATGCAGCCTTTGAGTTCCATCCATGTGAGAACAGAAACTCTAGCATTAA
CAAAACTAGAAGTCTGGTGGTATTTACTGATGAGACTTGGACCTCATCTTCCTGCTAATTTTGAACAGGTTTGTGTGCCTCTGATTCAAA
GTACAATAAGCATTGATTCTAATGCCTCACCTCAGGGCAATTCGTGTCATGTAGCTACATCTCCAGGTTTAAATCCTATGACTCCTGTAC
ACAAAGGTGCTTCCTCCCCGTACGGAGCCCCGGGAACTCCCCGAATGAACCTGAGTTCGAATTTAGGTGGAATGGCCACAATCCCATCCA
TTCAACTTTTGGGACTTGAAATGTTGCTTCATTTCTTGTTGGGTCCAGAAGCCTTGAGTTTTGCTAAGCAAAATAAACTTGTGCTGAGCT
TAGAGCCATTGGAACATCCGTTAATCAGCAGCCCTTCCTTTTTTTCCAAACATGCAAATACACTTATCACTGCTGTTCATGATAGCTTTG
TTGCAGTTGGAAAAGATGCCCCCGATGTGGTTGTCAGTGCTATCTGGAAGGAGCTAATTAGCTTGGTGAAGTCAGTTACTGAATCAGGTA
ACAAAAAAGAGAAACCAGGTTCTGAAGTTTTGACTCTCTTATTAAAGTCTTTGGAAAGCATAGTAAAGTCTGAAGTATTTCCTGTATCAA
AAACGCTGGTCCTCATGGAAATTACAATTAAAGGACTTCCTCAGAAAGTATTAGGTTCACCAGCATATCAGGTTGCTAATATGGATATTC
TTAATGGAACTCCAGCTTTGTTCTTAATTCAATTAATTTTCAACAATTTCTTGGAATGTGGTGTATCAGATGAAAGGTTCTTTCTCAGTT
TGGAATCACTTGTAGGCTGTGTTCTTTCTGGTCCAACTTCACCACTAGCTTTCAGTGACTCAGTTTTAAATGTTATTAATCAAAATGCAA
AGCAGTTGGAAAATAAGGAGCATCTCTGGAAAATGTGGAGTGTTATAGTCACCCCATTAACTGAATTGATTAATCAGACCAATGAAGTAA
ATCAAGGTGATGCCTTAGAACATAATTTTAGTGCCATCTATGGTGCATTGACTTTACCAGTAAACCACATTTTTTCAGAACAGAGATTTC
CAGTGGCCACCATGAAGACTTTGCTTAGAACTTGGTCAGAATTATATAGAGCATTTGCTCGTTGTGCTGCTTTGGTGGCAACAGCAGAAG
AGAACTTGTGCTGTGAGGAACTTTCTTCCAAGATAATGTCCAGTTTGGAAGATGAAGGCTTTTCTAATTTGTTGTTCGTGGATAGAATTA
TTTATATTATTACTGTAATGGTTGATTGCATTGACTTCTCACCATATAATATTAAATATCAGCCCAAAGTTAAATCACCACAGAGACCTT
CAGATTGGTCCAAAAAGAAGAATGAGCCCCTAGGGAAATTGACTTCTTTATTTAAACTTATTGTGAAAGTGATCTATTCTTTCCACACAC
TGAGCTTCAAGGAAGCACATTCTGATACCCTCTTCACTATTGGCAACTCAATCACCGGCATTATTTCCAGTGTACTTGGGCATATTTCTT
TGCCTTCTATGATCCGAAAAATATTTGCAACTTTAACAAGACCTCTGGCATTATTTTATGAAAACTCAAAGCTTGATGAAGTTCCTAAAG
TATATAGTTGTCTGAACAACAAGTTAGAAAAGCTACTGGGAGAAATTATTGCTTGTCTGCAATTCAGCTACACCGGAACTTATGATAGTG
AACTTCTTGAACAACTCTCCCCACTATTATGCATAATATTTCTGCACAAGAATAAACAGATTCGAAAACAGAGTGCTCAGTTCTGGAATG
CCACTTTTGCCAAAGTGATGATGTTGGTTTATCCTGAAGAGTTAAAACCAGTACTAACACAAGCCAAACAAAAATTTCTGCTCCTGTTGC
CTGGTTTGGAAACTGTTGAAATGATGGAGGAATCCAGTGGACCATATTCTGATGGAACAGAAAATTCACAACTAAATGTGAAGATAAGTG
GCATGGAGAGAAAATCAAATGGAAAAAGAGATTCATTTTTGGCACAAACAAAGAATAAAAAAGAAAATATGAAACCAGCAGCCAAACTGA
AACTTGAATCTTCGTCTTTAAAAGTAAAGGGTGAAATTCTTTTGGAAGAGGAAAAGTCTACTGACTTTGTGTTTATACCTCCAGAAGGAA
AAGATGCAAAGGAAAGAATATTAACTGATCATCAAAAAGAAGTTCTCAAAACAAAGCGGTGTGATATTCCTGCCATGTATAATAATCTGG
ATGTTTCCCAAGATACCTTATTTACTCAGTATAGTCAGGAAGAGCCTATGGAAATTCCTACTTTAACCAGAAAACCAAAGGAGGATTCTA
AGATGATGATTACGGCAGCCAACATCCCTCTGGTGTCAGAACTTGCCATCGATGACATTCATTTTGATGACTTTTCTCTCGACGTTGATG
CCATGATCACAGCTGCTCTCCGGATGTTCATGGAGCTGGGGATGGTACAGAAATTTAAAATTGACTATGAGACACTGTGTAGGTGGCTTT
TGACAGTGAGGAAAAACTATCGGATGGTTCTATACCACAACTGGAGACATGCCTTCAACGTGTGTCAGCTGATGTTCGCGATGTTAACCA
CTGCTGGGTTTCAAGACATTCTGACCGAGGTGGAAATTTTAGCGGTGATTGTGGGATGCCTGTGTCATGACCTCGACCACAGGGGAACCA
ACAATGCCTTCCAAGCTAAGAGTGGCTCTGCCCTGGCCCAACTCTATGGAACCTCTGCTACCTTGGAGCATCACCATTTCAACCACGCCG
TGATGATCCTTCAAAGTGAGGGTCACAATATCTTTGCTAACCTGTCCTCCAAGGAATATAGTGACCTTATGCAGCTTTTGAAGCAGTCAA
TATTGGCAACAGACCTCACGCTGTACTTTGAGAGGAGAACTGAATTCTTTGAACTTGTCAGTAAAGGAGAATACGATTGGAACATCAAAA
ACCATCGTGATATATTTCGATCAATGTTAATGACAGCCTGTGACCTTGGAGCCGTGACCAAACCGTGGGAGATCTCCAGACAGGTGGCAG
AACTTGTAACCAGTGAGTTCTTCGAACAAGGAGATCGGGAGAGATTAGAGCTCAAACTCACTCCTTCAGCAATTTTTGATCGGAACCGGA
AGGATGAACTGCCTCGGTTGCAACTGGAGTGGATTGATAGCATCTGCATGCCTTTGTATCAGGCACTGGTGAAGGTCAACGTGAAACTGA
AGCCGATGCTAGATTCAGTAGCTACAAACAGAAGTAAGTGGGAAGAGCTACACCAAAAACGACTGCTGGCCTCAACTGCCTCATCCTCCC
CTGCCAGTGTTATGGTAGCCAAGGAAGACAGGAACTAAACCTCCAGGTCAGCTGCAGCTGCAAAATGACTACAGCCTGAAGGGCCATTTT
CAGTCCAGCAATGTCATCCTTTTGTTCTTTTAGCTCAGAAAGACCTAACATCTCAAGGATGCACTGGGAAGCATGCCTGGGCTTTCACCT
TGAAGCATGGTCAGCAGCAGAGAGAGCAACGGGAAGGACAAAGAAAGAGGTGGGGCAGGGAGCACACCCCAGGACCCTCACTTTTCCCTA
ATGAACACGCATGGGCTGAAATGAAGGCTCTGGGTAGGGGACTGTTTTGGATCCAAGGACCTGTGGACAGTCGGCCTACTTACTCTGAGC
TGAGGGAACACTGAACAGTAAAAGCGTCATTAGCGCTGCTTCGTTTTGTATAGGGCTTTTCTGTTTGTTACAAGCCAAACACTGCCTGTC
TTTGCTTCCTGTCCCTGAATGCCTTTTTGTGCCAGACTGTCCCAAGAATCCTAATTTGTATTCCATAGAGGTATTTTATTTTTAATCCTA
GAGCTTCTTATTGATGGATCCTTTAGAATTGCCTACCTAAAAGGTAAACTATACTATCCTTATAAATACTGATCAATCCCAGTTCTCCCC
CTAAAAATGAATACATAGTAGGACTATAGCAAATGTGTTTGATGGGTAATTCTAGACTGGGACTATGGTACCCTTTTCCAGAGTTTTAAA
ATTCAACCTTCATTACAGACAAAGTTTTCTCCCAGAAGGAATGGATTGATAGATTTTGATTAAAGTAAGGGTGGAAGGAAATCTGTAGCT
GGATTTACCACAAGTGACATCTAGAAACTATAGTTCACAGGACAGAGCAGAGCCATGGAGACTAAGCATTGACTACCTTGAGTTCTCCTA
GTGAGGAGTTCTGGTATAAAATTTAAGATTACTACCAGTAACCAACTTAAAGCAAACTATAGGGGTCCCTAATTTTGGATTTTTCCTTAA
GTGTAAGAAACAATGCTTCAAATGTTAAGAAATAACAGTCTGGGCAAAGAACGCATATTCTATAGGAAGCCAGGTTTACAATAGGTAAGA
ATAAACTGTATTAAGTAGATGTAATGACTAGAAAGCTGCTTTGCTCCCTATATTGAGAAATTGTGGACATGGTATGTGTTATCCAAAGAA
CATTGGGCTAGAAGATAGATTTCTATCCTTAGCTTTGGCATTATTGACTGGATTGACTTGAACAAGTCACTTAACTTCTACAAGCTTGTT
TCCTTATTTGTCAAATTAGATTACACTAGGAAACGATTCTCGAACATGTTTTAACCTTACAACTCTTTGTTCAAATAAATCTTTCAATGA

>74084_74084_8_RIF1-PDE11A_RIF1_chr2_152318980_ENST00000444746_PDE11A_chr2_178592900_ENST00000358450_length(amino acids)=1478AA_BP=1141
MGAEGQRRREPCPDLPRVADMTARGQSPLAPLLETLEDPSASHGGQTDAYLTLTSRMTGEEGKEVITEIEKKLPRLYKVLKTHISSQNSE
LSSAALQALGFCLYNPKITSELSEANALELLSKLNDTIKNSDKNVRTRALWVISKQTFPSEVVGKMVSSIIDSLEILFNKGETHSAVVDF
EALNVIVRLIEQAPIQMGEEAVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEIASITEQLMTTKLISELQKLFMSKNETYVL
KLWPLFVKLLGRTLHRSGSFINSLLQLEELGFRSGAPMIKKIAFIAWKSLIDNFALNPDILCSAKRLKLLMQPLSSIHVRTETLALTKLE
VWWYLLMRLGPHLPANFEQVCVPLIQSTISIDSNASPQGNSCHVATSPGLNPMTPVHKGASSPYGAPGTPRMNLSSNLGGMATIPSIQLL
GLEMLLHFLLGPEALSFAKQNKLVLSLEPLEHPLISSPSFFSKHANTLITAVHDSFVAVGKDAPDVVVSAIWKELISLVKSVTESGNKKE
KPGSEVLTLLLKSLESIVKSEVFPVSKTLVLMEITIKGLPQKVLGSPAYQVANMDILNGTPALFLIQLIFNNFLECGVSDERFFLSLESL
VGCVLSGPTSPLAFSDSVLNVINQNAKQLENKEHLWKMWSVIVTPLTELINQTNEVNQGDALEHNFSAIYGALTLPVNHIFSEQRFPVAT
MKTLLRTWSELYRAFARCAALVATAEENLCCEELSSKIMSSLEDEGFSNLLFVDRIIYIITVMVDCIDFSPYNIKYQPKVKSPQRPSDWS
KKKNEPLGKLTSLFKLIVKVIYSFHTLSFKEAHSDTLFTIGNSITGIISSVLGHISLPSMIRKIFATLTRPLALFYENSKLDEVPKVYSC
LNNKLEKLLGEIIACLQFSYTGTYDSELLEQLSPLLCIIFLHKNKQIRKQSAQFWNATFAKVMMLVYPEELKPVLTQAKQKFLLLLPGLE
TVEMMEESSGPYSDGTENSQLNVKISGMERKSNGKRDSFLAQTKNKKENMKPAAKLKLESSSLKVKGEILLEEEKSTDFVFIPPEGKDAK
ERILTDHQKEVLKTKRCDIPAMYNNLDVSQDTLFTQYSQEEPMEIPTLTRKPKEDSKMMITAANIPLVSELAIDDIHFDDFSLDVDAMIT
AALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAF
QAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRD
IFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPML

--------------------------------------------------------------
>74084_74084_9_RIF1-PDE11A_RIF1_chr2_152318980_ENST00000453091_PDE11A_chr2_178592900_ENST00000286063_length(transcript)=10693nt_BP=3524nt
CGCACTCCTGGGCCCGCCCAGCCGCCATCTTGGTCTAGGAGGGAGCGCGCCGCACGCGTGAGTAAACAGCCGGAGCTGGGAAAGTCGAGC
TCTGGCAGCGTCTGGGTGCTGAGGGGCAGAGGCGGAGAGAACCCTGTCCTGATCTTCCTAGGGTGGCCGACATGACGGCCAGGGGTCAGA
GCCCCCTCGCGCCGCTGTTGGAGACTTTGGAAGACCCTTCTGCCTCCCATGGAGGGCAGACTGACGCTTACCTGACTCTGACCAGTCGTA
TGACTGGAGAAGAAGGAAAAGAAGTAATTACAGAAATTGAGAAAAAACTTCCTCGGCTGTACAAAGTTTTAAAGACTCACATTTCCAGTC
AAAACTCGGAGCTGAGTAGTGCTGCTCTACAAGCCCTGGGGTTTTGCTTATATAATCCCAAAATTACCTCAGAATTATCAGAGGCAAATG
CTCTAGAATTGCTTTCAAAATTGAATGATACCATTAAGAATTCAGACAAAAATGTACGTACTAGAGCACTTTGGGTGATATCTAAGCAGA
CATTTCCCTCTGAAGTGGTTGGCAAAATGGTATCCAGTATAATTGATTCATTAGAAATACTGTTTAACAAAGGAGAGACGCATTCTGCTG
TTGTTGATTTTGAAGCATTAAATGTTATCGTAAGGCTAATTGAACAAGCCCCAATTCAAATGGGAGAAGAGGCAGTGAGGTGGGCAAAAC
TGGTCATACCTTTAGTGGTTCATTCAGCACAAAAGGTACATTTGCGGGGAGCAACTGCTCTGGAGATGGGAATGCCATTATTGCTTCAGA
AACAGCAAGAAATAGCATCTATTACGGAGCAGCTTATGACTACTAAATTAATCTCAGAACTTCAGAAGCTATTTATGAGTAAAAATGAGA
CTTACGTGTTAAAATTATGGCCTTTGTTTGTCAAACTACTTGGAAGGACCTTGCATCGAAGTGGGAGTTTCATCAATTCTCTCTTGCAAC
TAGAAGAACTTGGATTTCGTAGTGGAGCACCCATGATTAAAAAGATAGCTTTTATTGCTTGGAAGAGTTTAATAGATAATTTTGCTTTAA
ATCCAGATATACTATGTAGTGCAAAAAGACTCAAGTTGTTAATGCAGCCTTTGAGTTCCATCCATGTGAGAACAGAAACTCTAGCATTAA
CAAAACTAGAAGTCTGGTGGTATTTACTGATGAGACTTGGACCTCATCTTCCTGCTAATTTTGAACAGGTTTGTGTGCCTCTGATTCAAA
GTACAATAAGCATTGATTCTAATGCCTCACCTCAGGGCAATTCGTGTCATGTAGCTACATCTCCAGGTTTAAATCCTATGACTCCTGTAC
ACAAAGGTGCTTCCTCCCCGTACGGAGCCCCGGGAACTCCCCGAATGAACCTGAGTTCGAATTTAGGTGGAATGGCCACAATCCCATCCA
TTCAACTTTTGGGACTTGAAATGTTGCTTCATTTCTTGTTGGGTCCAGAAGCCTTGAGTTTTGCTAAGCAAAATAAACTTGTGCTGAGCT
TAGAGCCATTGGAACATCCGTTAATCAGCAGCCCTTCCTTTTTTTCCAAACATGCAAATACACTTATCACTGCTGTTCATGATAGCTTTG
TTGCAGTTGGAAAAGATGCCCCCGATGTGGTTGTCAGTGCTATCTGGAAGGAGCTAATTAGCTTGGTGAAGTCAGTTACTGAATCAGGTA
ACAAAAAAGAGAAACCAGGTTCTGAAGTTTTGACTCTCTTATTAAAGTCTTTGGAAAGCATAGTAAAGTCTGAAGTATTTCCTGTATCAA
AAACGCTGGTCCTCATGGAAATTACAATTAAAGGACTTCCTCAGAAAGTATTAGGTTCACCAGCATATCAGGTTGCTAATATGGATATTC
TTAATGGAACTCCAGCTTTGTTCTTAATTCAATTAATTTTCAACAATTTCTTGGAATGTGGTGTATCAGATGAAAGGTTCTTTCTCAGTT
TGGAATCACTTGTAGGCTGTGTTCTTTCTGGTCCAACTTCACCACTAGCTTTCAGTGACTCAGTTTTAAATGTTATTAATCAAAATGCAA
AGCAGTTGGAAAATAAGGAGCATCTCTGGAAAATGTGGAGTGTTATAGTCACCCCATTAACTGAATTGATTAATCAGACCAATGAAGTAA
ATCAAGGTGATGCCTTAGAACATAATTTTAGTGCCATCTATGGTGCATTGACTTTACCAGTAAACCACATTTTTTCAGAACAGAGATTTC
CAGTGGCCACCATGAAGACTTTGCTTAGAACTTGGTCAGAATTATATAGAGCATTTGCTCGTTGTGCTGCTTTGGTGGCAACAGCAGAAG
AGAACTTGTGCTGTGAGGAACTTTCTTCCAAGATAATGTCCAGTTTGGAAGATGAAGGCTTTTCTAATTTGTTGTTCGTGGATAGAATTA
TTTATATTATTACTGTAATGGTTGATTGCATTGACTTCTCACCATATAATATTAAATATCAGCCCAAAGTTAAATCACCACAGAGACCTT
CAGATTGGTCCAAAAAGAAGAATGAGCCCCTAGGGAAATTGACTTCTTTATTTAAACTTATTGTGAAAGTGATCTATTCTTTCCACACAC
TGAGCTTCAAGGAAGCACATTCTGATACCCTCTTCACTATTGGCAACTCAATCACCGGCATTATTTCCAGTGTACTTGGGCATATTTCTT
TGCCTTCTATGATCCGAAAAATATTTGCAACTTTAACAAGACCTCTGGCATTATTTTATGAAAACTCAAAGCTTGATGAAGTTCCTAAAG
TATATAGTTGTCTGAACAACAAGTTAGAAAAGCTACTGGGAGAAATTATTGCTTGTCTGCAATTCAGCTACACCGGAACTTATGATAGTG
AACTTCTTGAACAACTCTCCCCACTATTATGCATAATATTTCTGCACAAGAATAAACAGATTCGAAAACAGAGTGCTCAGTTCTGGAATG
CCACTTTTGCCAAAGTGATGATGTTGGTTTATCCTGAAGAGTTAAAACCAGTACTAACACAAGCCAAACAAAAATTTCTGCTCCTGTTGC
CTGGTTTGGAAACTGTTGAAATGATGGAGGAATCCAGTGGACCATATTCTGATGGAACAGAAAATTCACAACTAAATGTGAAGATAAGTG
GCATGGAGAGAAAATCAAATGGAAAAAGAGATTCATTTTTGGCACAAACAAAGAATAAAAAAGAAAATATGAAACCAGCAGCCAAACTGA
AACTTGAATCTTCGTCTTTAAAAGTAAAGGGTGAAATTCTTTTGGAAGAGGAAAAGTCTACTGACTTTGTGTTTATACCTCCAGAAGGAA
AAGATGCAAAGGAAAGAATATTAACTGATCATCAAAAAGAAGTTCTCAAAACAAAGCGGTGTGATATTCCTGCCATGTATAATAATCTGG
ATGTTTCCCAAGATACCTTATTTACTCAGTATAGTCAGGAAGAGCCTATGGAAATTCCTACTTTAACCAGAAAACCAAAGGAGGATTCTA
AGATGATGATTACGGCAGCCAACATCCCTCTGGTGTCAGAACTTGCCATCGATGACATTCATTTTGATGACTTTTCTCTCGACGTTGATG
CCATGATCACAGCTGCTCTCCGGATGTTCATGGAGCTGGGGATGGTACAGAAATTTAAAATTGACTATGAGACACTGTGTAGGTGGCTTT
TGACAGTGAGGAAAAACTATCGGATGGTTCTATACCACAACTGGAGACATGCCTTCAACGTGTGTCAGCTGATGTTCGCGATGTTAACCA
CTGCTGGGTTTCAAGACATTCTGACCGAGGTGGAAATTTTAGCGGTGATTGTGGGATGCCTGTGTCATGACCTCGACCACAGGGGAACCA
ACAATGCCTTCCAAGCTAAGAGTGGCTCTGCCCTGGCCCAACTCTATGGAACCTCTGCTACCTTGGAGCATCACCATTTCAACCACGCCG
TGATGATCCTTCAAAGTGAGGGTCACAATATCTTTGCTAACCTGTCCTCCAAGGAATATAGTGACCTTATGCAGCTTTTGAAGCAGTCAA
TATTGGCAACAGACCTCACGCTGTACTTTGAGAGGAGAACTGAATTCTTTGAACTTGTCAGTAAAGGAGAATACGATTGGAACATCAAAA
ACCATCGTGATATATTTCGATCAATGTTAATGACAGCCTGTGACCTTGGAGCCGTGACCAAACCGTGGGAGATCTCCAGACAGGTGGCAG
AACTTGTAACCAGTGAGTTCTTCGAACAAGGAGATCGGGAGAGATTAGAGCTCAAACTCACTCCTTCAGCAATTTTTGATCGGAACCGGA
AGGATGAACTGCCTCGGTTGCAACTGGAGTGGATTGATAGCATCTGCATGCCTTTGTATCAGGCACTGGTGAAGGTCAACGTGAAACTGA
AGCCGATGCTAGATTCAGTAGCTACAAACAGAAGTAAGTGGGAAGAGCTACACCAAAAACGACTGCTGGCCTCAACTGCCTCATCCTCCC
CTGCCAGTGTTATGGTAGCCAAGGAAGACAGGAACTAAACCTCCAGGTCAGCTGCAGCTGCAAAATGACTACAGCCTGAAGGGCCATTTT
CAGTCCAGCAATGTCATCCTTTTGTTCTTTTAGCTCAGAAAGACCTAACATCTCAAGGATGCACTGGGAAGCATGCCTGGGCTTTCACCT
TGAAGCATGGTCAGCAGCAGAGAGAGCAACGGGAAGGACAAAGAAAGAGGTGGGGCAGGGAGCACACCCCAGGACCCTCACTTTTCCCTA
ATGAACACGCATGGGCTGAAATGAAGGCTCTGGGTAGGGGACTGTTTTGGATCCAAGGACCTGTGGACAGTCGGCCTACTTACTCTGAGC
TGAGGGAACACTGAACAGTAAAAGCGTCATTAGCGCTGCTTCGTTTTGTATAGGGCTTTTCTGTTTGTTACAAGCCAAACACTGCCTGTC
TTTGCTTCCTGTCCCTGAATGCCTTTTTGTGCCAGACTGTCCCAAGAATCCTAATTTGTATTCCATAGAGGTATTTTATTTTTAATCCTA
GAGCTTCTTATTGATGGATCCTTTAGAATTGCCTACCTAAAAGGTAAACTATACTATCCTTATAAATACTGATCAATCCCAGTTCTCCCC
CTAAAAATGAATACATAGTAGGACTATAGCAAATGTGTTTGATGGGTAATTCTAGACTGGGACTATGGTACCCTTTTCCAGAGTTTTAAA
ATTCAACCTTCATTACAGACAAAGTTTTCTCCCAGAAGGAATGGATTGATAGATTTTGATTAAAGTAAGGGTGGAAGGAAATCTGTAGCT
GGATTTACCACAAGTGACATCTAGAAACTATAGTTCACAGGACAGAGCAGAGCCATGGAGACTAAGCATTGACTACCTTGAGTTCTCCTA
GTGAGGAGTTCTGGTATAAAATTTAAGATTACTACCAGTAACCAACTTAAAGCAAACTATAGGGGTCCCTAATTTTGGATTTTTCCTTAA
GTGTAAGAAACAATGCTTCAAATGTTAAGAAATAACAGTCTGGGCAAAGAACGCATATTCTATAGGAAGCCAGGTTTACAATAGGTAAGA
ATAAACTGTATTAAGTAGATGTAATGACTAGAAAGCTGCTTTGCTCCCTATATTGAGAAATTGTGGACATGGTATGTGTTATCCAAAGAA
CATTGGGCTAGAAGATAGATTTCTATCCTTAGCTTTGGCATTATTGACTGGATTGACTTGAACAAGTCACTTAACTTCTACAAGCTTGTT
TCCTTATTTGTCAAATTAGATTACACTAGGAAACGATTCTCGAACATGTTTTAACCTTACAACTCTTTGTTCAAATAAATCTTTCAATGA
ATCCCCAACATATAAAACGTCAAAAAGCTGAATTCCTATGTGAATTATAAGCAGGGTTTGGACATCCAGAGCACCTACAAACCTTCATCT
CTTTGATTACGTACATGGGGGTCCACAGGGACTCTGAAGAGTTTGAAAATCCCTGGCCTAGATTAAACCTGAGAGCCATTCTAGCTCTTA
AAAAAATCTGAAATTTACAAACCATTTTTCTTGTTATTGTTTTTGTTTCTTTGTTTGTTTGTTTTTTGAGACTGAGTTTTCACTCTTGTT
GCCCAGGCTGGAGTGCAATGGCGTGATCTCGGCTTACTGCAACCTCTGCTTCCTGGGTTCAAGCAATTCTCCAGCCTCAACCTCCTGAGA
AGCTGGGATTACAGGTGCCTGCCACCACGCCTGGCTAATTTTTGTACTTTTAGTAGACACAGGGTTTCACCATGTTTGCCAGGCTGATCT
CAAACTCCTGACCTCAGGTGAGCCACCCACCTCTGCCTCCGAAAGTGCTGGGATTACAGGCGTGAGCCACCGTACCCGGCCCTTGTTATT
GTTATTAATCATTATCAATCATTAACTTTACAGATATTAAAGAAATAGGGGCCATGTTCTACATGCGACATTGTTTTCCTGGCACACAGT
AGACAATTCAGGAAATGTCTGAAGAAGGAATGGGTAAAATTAAGATACCAAAATGGAATTGAGGGGAGAGCAGGTAATTGTAGAGAAAAA
GACTCTTTATGGCAAGAAACAAAGTAAAAGAAATGTATAGACCGGGCGCGGTGGCTCACGCCTGTAATCCCAGCAATTTGGAAGGCCGAG
GCGGGCGGATCACGAGGTCAGGAGATCGAGACCGTCCTGGCTAACACGGTGAAACCCTGTCTCTACTAAAAAACACAAAACAAATTAGCC
AGGCGCGGTGGCAGGCGTCTGTAGTCCCAGCTACTGGGGAGGCTGAGGCAAGAGAATGGCGGGAACCCGCGAGGCGGAGCTTGCAGTGAG
TCGAGATCACGTCACTGCCCTCCAGCCTGGGCGACCAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGTA
TAAACCAGACTAAGAGGGGAATAAAAGCAAGAAGAAAAAGAAACGTAAGAACACCAGTAAAGGAAAGACAGGGACCGAGACAGGTGGTTA
AGGGAAATGAAAAAAAAAAAAAAAAGGTGAAAGTCAATCCAAACAAAGAAAAATGGCACTTCCAACCAAAAAAAATGAAGGTGTAGAACC
CTGTCATCAATTGCTCAGAAAAGAGAGACACTTGAGCAGGGAGGGGTTTGAGAAAGGGGAGAAGGAAGGAGTGAGAGCCCTAAAAAATAA
TGTTCCTAGCTACCCTTTACAGCTGTCTCTGCAGGGAAGACTGGAGAAAGTAGAGGGGGAAATGAATGCAGGAAGAAACTGCCTCTGCAG
AGCAGGTAAGAGGAGGTTGTTCAGATTTATGGATTTTATTAAGCCAGTTTTCTGTATCACTCTGCTATAAAGGAAAATAGCTTCTGCAGG
GCTGTCTCTCCTCCTTCAGGTGGGGAACAAAGGGTGGGTGGAGTCAGGGACAGAGTCTGGTCTGCGAGATCGTGACGTGTCTGCAGCTCC
GAAGCACTGCAGGTGTTTCTGGGTAATGTGCCACATCATGTTTATATCACGAACGGGAATTGAAAATCAGTCTGTGTGAGGCAGAGATGA
GCCCACATCTGTTATCCTCCCCAACAATAAATAAATAAATAGCCCAGACAAATGGATGCCAGTCCATCTACAGCAACATTTTAAAGCATG
TGCTTTATGACAAAACTGGACCCAGGGTCTGACAGAGACTGCAGGCTGCCGTGAGCACTGTAGCTATCCTGAACATTGATGCTACATATT
GCTAAGGGGAACATAATTTATAGCATAAACCCTACAAGCTTCCACTAAGGTTGAGTTTTCCTCTCATTTTCTTGCCGTTTTATTGGCTTC
ACTGCATGGTTGCCAATAGCAACATCCACTGGTAGCAAGGGGAGTTCAACACCATTGCAATCTGCCATACAGTGGAGCCCTGACAATGTC
AACCATCAATCTAGTAGCTGTTTGTAATTGCCTCCATCTATTTCTCCTGTCTTGAGGTATCTTTCCTATTGTGGGTCAAGATTTAGAAAC
TGCTGACTAATGCCATGGGTCTGTGTCTCCATGACTATGAAGCAGTGGACAGGAAGGTAGCAGCTTCCTGGTGCCAACAACCCCAGAGGT
TAGAGGTTGAACTCTTGCGGGTTTCAGGCGTTTTTAATCCCTTTTCTAAACAATTTATAATTTTGCAAGAATGTGAGGCATATGCAGTTA
TCCATATAATCTGCTTTTCCAAAAAAGAGAAAGGAAGTTTCCCAGTCCTTATTATTAATGTTTATTTCCTATTGGAGAAAGACATTTGAA
ATATGAGCCTTCTTGTAAAAACTCAAACTGACCAGATTATGTTTGCTTCCTCAGGTCTCTTGGCATTAATTGTTGAAATAACTTCATCCT
ACTTTTTCGATGAGATGTATTTTTTTCAGACATATTTATTCTTACTAGTCACTATGTAGCTATTATGTGCACAATCTACAATGTAGTGGC
AATCCTGGTGGGTAGGGACAGCTTCACATACTGCAAAGGGTGCCATTCAGTGCATAGCAGACTGGAACTCCCTCCTAGCTTGGCCACCAG
CTGAACCTGTAATCTTAGGACTCTCCAAGTCTTAGAATCTCCATCTATTACATAAAAGCACTGACTTTTATTCAGTCCCCACACCAAAGG
ACCAAGACGTGTTTAGCTTTAAAGAAATTTTCCAGATAATTTTCTTTTTTATTCTTCTCAAATAAAATAGCAACAAACCTAAAGCAGTCA
TCTTCTTAATAAAGACATAATAAAACTTACATATATGGGGTAGATGTAAGCACAATCATACTACAGATGTATCTTGAGCCTGTCTCTAAT
TATGATGAAAGATGTAGTCATCAATACAATTTAAAAAAAGATATGTCCTTTTTTTGAGACAGGGTCTTGCTCTGTCACCCAGGCTGGAGG
GCAGTGGCACAATCACAGCCACTGCAGCCTTGACCTCTCCAACTTAAGTGATCTTTCCTGCCTCAGCCTCATGAGTAGCTGGGACCACAG
GTGTGCACCACCACACCCAGCTAAATTTTGTATTGTTTGTAAAGACGAGGCCTCACTATGCTGACCACACTGGTCTCGAACTCCTGGGCT
CAAGCAATCCTCCTGCCTTGGCCTCCCAAAGTGTTAGGGTTAGAGATATGAACCACCACACCCACCTTATATGTCCTTTTATTTCATAAA
AAACAATTTTAGATTATCTGATATCACACATATCCCATAAATGGTAGTCATTAATTTAGAAGTGAATTTATAAAGTTAAGAGAAGTTAAA
ATTGCACATGCATTTTGTTTCTAAAATCTGAGATGTCTATGCATTTCCAGGTATTGTATATTTGCAAATACATTGGGTTAGAAATCATCT
TTAACATTTTGTGTTAGTGTAATAACAATATTATCTAATATTAATGCTGCCAGAATCCAGTTGCTTTTTCTGTGTATCAAAATTTATCAT
AACTTTTTCCACTTAACACTAGGTAATTAAACAGAATCTGCCCAATTTATTCTGCAGTAAAATTATTTTAAAATCTATTTTTCCTGCTGA
CTCTTAGAAATTGCAGAAAGACAAAAACCAGTTTCATCTCCAGTAATAGTGTGAAACAATTTCCTTCCAGTGGGACAGAAACCTAGACAT
ACTAGGGAAAGATTTAAATATAAAGAAAAATGCCTTGGCTGAAAAAAAAAAAAACCACCAAAACACAAAAAGGATTCATTAAAGCAACAG
AACAAAACCTAATTTGGGACCCTAAAAACTCTGGCAATGCCACTGTAATGAAGTTTCATTATCTGCTTCAGAGTAACAGTCTCTGAAATT
GTTATTCTGCTACATGCTGTAAAGAACTCCCAAAACTCAAATGTATCAGGAAATGTAAAGGTTAAGTCTGACTACAAGAAGGCCAAAATT
GCACCAGCTTCCTAAGTGAAGAATAATAGAATAAAACATATAGAGGGCAGAAATAAAATGAGGTGTATCTGGAGAATTTCATGATGAGCA
TTTAGATTTAGCAATGCCCAATGTCATGCTGACACTGTTTGTCATGACCTTGTCTTCAGCTAGTAATTTGGGGTTGTACTTTTTTAAATT
TAATTTTGAATGTTCTTGCATGTTTGGTACCTCTCTCCTCACTGCTAAAGATAAATTGTTTATCTGTATAACATAACTACACCAATGTCA
TTTTTGTATACGCTAGTACACAAATGTGTTTTTTTATTAAGTAATGAAGTATTTGCTGTGAAAAATGTATTATTTGTGCCACCGTTTATA
TCTGTGTTCATTTTCTGTGTGTATATGCGTGTGTATTCGAATCTCAATTTTTCTTTTACTCTAGTTTAGATTAAGACATATTTAGATGAA
ATTTTAAAAATAACATTGGAAATAGGAGGCTAAGTTTTGTTGAGTCTCATTCCCTTGGGGGGAAATTGCTTTTGCCATTTTATTTTCATG
TACAATAACCTAAAAAGGATCTCCTACTGACTTCCTTCCTAATTATTATTGTTTTACACGAAAGAAAGGAAATACGTTTTCAATTGAGTT
GTTTGAAATCATTCACTTTGTGTAGATTTCCCAGACTGATGTTTCATTGTAAGAATATTACATTATAGACAGGTTGGCCATTTCACAAGC

>74084_74084_9_RIF1-PDE11A_RIF1_chr2_152318980_ENST00000453091_PDE11A_chr2_178592900_ENST00000286063_length(amino acids)=1478AA_BP=1141
MGAEGQRRREPCPDLPRVADMTARGQSPLAPLLETLEDPSASHGGQTDAYLTLTSRMTGEEGKEVITEIEKKLPRLYKVLKTHISSQNSE
LSSAALQALGFCLYNPKITSELSEANALELLSKLNDTIKNSDKNVRTRALWVISKQTFPSEVVGKMVSSIIDSLEILFNKGETHSAVVDF
EALNVIVRLIEQAPIQMGEEAVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEIASITEQLMTTKLISELQKLFMSKNETYVL
KLWPLFVKLLGRTLHRSGSFINSLLQLEELGFRSGAPMIKKIAFIAWKSLIDNFALNPDILCSAKRLKLLMQPLSSIHVRTETLALTKLE
VWWYLLMRLGPHLPANFEQVCVPLIQSTISIDSNASPQGNSCHVATSPGLNPMTPVHKGASSPYGAPGTPRMNLSSNLGGMATIPSIQLL
GLEMLLHFLLGPEALSFAKQNKLVLSLEPLEHPLISSPSFFSKHANTLITAVHDSFVAVGKDAPDVVVSAIWKELISLVKSVTESGNKKE
KPGSEVLTLLLKSLESIVKSEVFPVSKTLVLMEITIKGLPQKVLGSPAYQVANMDILNGTPALFLIQLIFNNFLECGVSDERFFLSLESL
VGCVLSGPTSPLAFSDSVLNVINQNAKQLENKEHLWKMWSVIVTPLTELINQTNEVNQGDALEHNFSAIYGALTLPVNHIFSEQRFPVAT
MKTLLRTWSELYRAFARCAALVATAEENLCCEELSSKIMSSLEDEGFSNLLFVDRIIYIITVMVDCIDFSPYNIKYQPKVKSPQRPSDWS
KKKNEPLGKLTSLFKLIVKVIYSFHTLSFKEAHSDTLFTIGNSITGIISSVLGHISLPSMIRKIFATLTRPLALFYENSKLDEVPKVYSC
LNNKLEKLLGEIIACLQFSYTGTYDSELLEQLSPLLCIIFLHKNKQIRKQSAQFWNATFAKVMMLVYPEELKPVLTQAKQKFLLLLPGLE
TVEMMEESSGPYSDGTENSQLNVKISGMERKSNGKRDSFLAQTKNKKENMKPAAKLKLESSSLKVKGEILLEEEKSTDFVFIPPEGKDAK
ERILTDHQKEVLKTKRCDIPAMYNNLDVSQDTLFTQYSQEEPMEIPTLTRKPKEDSKMMITAANIPLVSELAIDDIHFDDFSLDVDAMIT
AALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAF
QAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRD
IFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPML

--------------------------------------------------------------
>74084_74084_10_RIF1-PDE11A_RIF1_chr2_152318980_ENST00000453091_PDE11A_chr2_178592900_ENST00000358450_length(transcript)=5876nt_BP=3524nt
CGCACTCCTGGGCCCGCCCAGCCGCCATCTTGGTCTAGGAGGGAGCGCGCCGCACGCGTGAGTAAACAGCCGGAGCTGGGAAAGTCGAGC
TCTGGCAGCGTCTGGGTGCTGAGGGGCAGAGGCGGAGAGAACCCTGTCCTGATCTTCCTAGGGTGGCCGACATGACGGCCAGGGGTCAGA
GCCCCCTCGCGCCGCTGTTGGAGACTTTGGAAGACCCTTCTGCCTCCCATGGAGGGCAGACTGACGCTTACCTGACTCTGACCAGTCGTA
TGACTGGAGAAGAAGGAAAAGAAGTAATTACAGAAATTGAGAAAAAACTTCCTCGGCTGTACAAAGTTTTAAAGACTCACATTTCCAGTC
AAAACTCGGAGCTGAGTAGTGCTGCTCTACAAGCCCTGGGGTTTTGCTTATATAATCCCAAAATTACCTCAGAATTATCAGAGGCAAATG
CTCTAGAATTGCTTTCAAAATTGAATGATACCATTAAGAATTCAGACAAAAATGTACGTACTAGAGCACTTTGGGTGATATCTAAGCAGA
CATTTCCCTCTGAAGTGGTTGGCAAAATGGTATCCAGTATAATTGATTCATTAGAAATACTGTTTAACAAAGGAGAGACGCATTCTGCTG
TTGTTGATTTTGAAGCATTAAATGTTATCGTAAGGCTAATTGAACAAGCCCCAATTCAAATGGGAGAAGAGGCAGTGAGGTGGGCAAAAC
TGGTCATACCTTTAGTGGTTCATTCAGCACAAAAGGTACATTTGCGGGGAGCAACTGCTCTGGAGATGGGAATGCCATTATTGCTTCAGA
AACAGCAAGAAATAGCATCTATTACGGAGCAGCTTATGACTACTAAATTAATCTCAGAACTTCAGAAGCTATTTATGAGTAAAAATGAGA
CTTACGTGTTAAAATTATGGCCTTTGTTTGTCAAACTACTTGGAAGGACCTTGCATCGAAGTGGGAGTTTCATCAATTCTCTCTTGCAAC
TAGAAGAACTTGGATTTCGTAGTGGAGCACCCATGATTAAAAAGATAGCTTTTATTGCTTGGAAGAGTTTAATAGATAATTTTGCTTTAA
ATCCAGATATACTATGTAGTGCAAAAAGACTCAAGTTGTTAATGCAGCCTTTGAGTTCCATCCATGTGAGAACAGAAACTCTAGCATTAA
CAAAACTAGAAGTCTGGTGGTATTTACTGATGAGACTTGGACCTCATCTTCCTGCTAATTTTGAACAGGTTTGTGTGCCTCTGATTCAAA
GTACAATAAGCATTGATTCTAATGCCTCACCTCAGGGCAATTCGTGTCATGTAGCTACATCTCCAGGTTTAAATCCTATGACTCCTGTAC
ACAAAGGTGCTTCCTCCCCGTACGGAGCCCCGGGAACTCCCCGAATGAACCTGAGTTCGAATTTAGGTGGAATGGCCACAATCCCATCCA
TTCAACTTTTGGGACTTGAAATGTTGCTTCATTTCTTGTTGGGTCCAGAAGCCTTGAGTTTTGCTAAGCAAAATAAACTTGTGCTGAGCT
TAGAGCCATTGGAACATCCGTTAATCAGCAGCCCTTCCTTTTTTTCCAAACATGCAAATACACTTATCACTGCTGTTCATGATAGCTTTG
TTGCAGTTGGAAAAGATGCCCCCGATGTGGTTGTCAGTGCTATCTGGAAGGAGCTAATTAGCTTGGTGAAGTCAGTTACTGAATCAGGTA
ACAAAAAAGAGAAACCAGGTTCTGAAGTTTTGACTCTCTTATTAAAGTCTTTGGAAAGCATAGTAAAGTCTGAAGTATTTCCTGTATCAA
AAACGCTGGTCCTCATGGAAATTACAATTAAAGGACTTCCTCAGAAAGTATTAGGTTCACCAGCATATCAGGTTGCTAATATGGATATTC
TTAATGGAACTCCAGCTTTGTTCTTAATTCAATTAATTTTCAACAATTTCTTGGAATGTGGTGTATCAGATGAAAGGTTCTTTCTCAGTT
TGGAATCACTTGTAGGCTGTGTTCTTTCTGGTCCAACTTCACCACTAGCTTTCAGTGACTCAGTTTTAAATGTTATTAATCAAAATGCAA
AGCAGTTGGAAAATAAGGAGCATCTCTGGAAAATGTGGAGTGTTATAGTCACCCCATTAACTGAATTGATTAATCAGACCAATGAAGTAA
ATCAAGGTGATGCCTTAGAACATAATTTTAGTGCCATCTATGGTGCATTGACTTTACCAGTAAACCACATTTTTTCAGAACAGAGATTTC
CAGTGGCCACCATGAAGACTTTGCTTAGAACTTGGTCAGAATTATATAGAGCATTTGCTCGTTGTGCTGCTTTGGTGGCAACAGCAGAAG
AGAACTTGTGCTGTGAGGAACTTTCTTCCAAGATAATGTCCAGTTTGGAAGATGAAGGCTTTTCTAATTTGTTGTTCGTGGATAGAATTA
TTTATATTATTACTGTAATGGTTGATTGCATTGACTTCTCACCATATAATATTAAATATCAGCCCAAAGTTAAATCACCACAGAGACCTT
CAGATTGGTCCAAAAAGAAGAATGAGCCCCTAGGGAAATTGACTTCTTTATTTAAACTTATTGTGAAAGTGATCTATTCTTTCCACACAC
TGAGCTTCAAGGAAGCACATTCTGATACCCTCTTCACTATTGGCAACTCAATCACCGGCATTATTTCCAGTGTACTTGGGCATATTTCTT
TGCCTTCTATGATCCGAAAAATATTTGCAACTTTAACAAGACCTCTGGCATTATTTTATGAAAACTCAAAGCTTGATGAAGTTCCTAAAG
TATATAGTTGTCTGAACAACAAGTTAGAAAAGCTACTGGGAGAAATTATTGCTTGTCTGCAATTCAGCTACACCGGAACTTATGATAGTG
AACTTCTTGAACAACTCTCCCCACTATTATGCATAATATTTCTGCACAAGAATAAACAGATTCGAAAACAGAGTGCTCAGTTCTGGAATG
CCACTTTTGCCAAAGTGATGATGTTGGTTTATCCTGAAGAGTTAAAACCAGTACTAACACAAGCCAAACAAAAATTTCTGCTCCTGTTGC
CTGGTTTGGAAACTGTTGAAATGATGGAGGAATCCAGTGGACCATATTCTGATGGAACAGAAAATTCACAACTAAATGTGAAGATAAGTG
GCATGGAGAGAAAATCAAATGGAAAAAGAGATTCATTTTTGGCACAAACAAAGAATAAAAAAGAAAATATGAAACCAGCAGCCAAACTGA
AACTTGAATCTTCGTCTTTAAAAGTAAAGGGTGAAATTCTTTTGGAAGAGGAAAAGTCTACTGACTTTGTGTTTATACCTCCAGAAGGAA
AAGATGCAAAGGAAAGAATATTAACTGATCATCAAAAAGAAGTTCTCAAAACAAAGCGGTGTGATATTCCTGCCATGTATAATAATCTGG
ATGTTTCCCAAGATACCTTATTTACTCAGTATAGTCAGGAAGAGCCTATGGAAATTCCTACTTTAACCAGAAAACCAAAGGAGGATTCTA
AGATGATGATTACGGCAGCCAACATCCCTCTGGTGTCAGAACTTGCCATCGATGACATTCATTTTGATGACTTTTCTCTCGACGTTGATG
CCATGATCACAGCTGCTCTCCGGATGTTCATGGAGCTGGGGATGGTACAGAAATTTAAAATTGACTATGAGACACTGTGTAGGTGGCTTT
TGACAGTGAGGAAAAACTATCGGATGGTTCTATACCACAACTGGAGACATGCCTTCAACGTGTGTCAGCTGATGTTCGCGATGTTAACCA
CTGCTGGGTTTCAAGACATTCTGACCGAGGTGGAAATTTTAGCGGTGATTGTGGGATGCCTGTGTCATGACCTCGACCACAGGGGAACCA
ACAATGCCTTCCAAGCTAAGAGTGGCTCTGCCCTGGCCCAACTCTATGGAACCTCTGCTACCTTGGAGCATCACCATTTCAACCACGCCG
TGATGATCCTTCAAAGTGAGGGTCACAATATCTTTGCTAACCTGTCCTCCAAGGAATATAGTGACCTTATGCAGCTTTTGAAGCAGTCAA
TATTGGCAACAGACCTCACGCTGTACTTTGAGAGGAGAACTGAATTCTTTGAACTTGTCAGTAAAGGAGAATACGATTGGAACATCAAAA
ACCATCGTGATATATTTCGATCAATGTTAATGACAGCCTGTGACCTTGGAGCCGTGACCAAACCGTGGGAGATCTCCAGACAGGTGGCAG
AACTTGTAACCAGTGAGTTCTTCGAACAAGGAGATCGGGAGAGATTAGAGCTCAAACTCACTCCTTCAGCAATTTTTGATCGGAACCGGA
AGGATGAACTGCCTCGGTTGCAACTGGAGTGGATTGATAGCATCTGCATGCCTTTGTATCAGGCACTGGTGAAGGTCAACGTGAAACTGA
AGCCGATGCTAGATTCAGTAGCTACAAACAGAAGTAAGTGGGAAGAGCTACACCAAAAACGACTGCTGGCCTCAACTGCCTCATCCTCCC
CTGCCAGTGTTATGGTAGCCAAGGAAGACAGGAACTAAACCTCCAGGTCAGCTGCAGCTGCAAAATGACTACAGCCTGAAGGGCCATTTT
CAGTCCAGCAATGTCATCCTTTTGTTCTTTTAGCTCAGAAAGACCTAACATCTCAAGGATGCACTGGGAAGCATGCCTGGGCTTTCACCT
TGAAGCATGGTCAGCAGCAGAGAGAGCAACGGGAAGGACAAAGAAAGAGGTGGGGCAGGGAGCACACCCCAGGACCCTCACTTTTCCCTA
ATGAACACGCATGGGCTGAAATGAAGGCTCTGGGTAGGGGACTGTTTTGGATCCAAGGACCTGTGGACAGTCGGCCTACTTACTCTGAGC
TGAGGGAACACTGAACAGTAAAAGCGTCATTAGCGCTGCTTCGTTTTGTATAGGGCTTTTCTGTTTGTTACAAGCCAAACACTGCCTGTC
TTTGCTTCCTGTCCCTGAATGCCTTTTTGTGCCAGACTGTCCCAAGAATCCTAATTTGTATTCCATAGAGGTATTTTATTTTTAATCCTA
GAGCTTCTTATTGATGGATCCTTTAGAATTGCCTACCTAAAAGGTAAACTATACTATCCTTATAAATACTGATCAATCCCAGTTCTCCCC
CTAAAAATGAATACATAGTAGGACTATAGCAAATGTGTTTGATGGGTAATTCTAGACTGGGACTATGGTACCCTTTTCCAGAGTTTTAAA
ATTCAACCTTCATTACAGACAAAGTTTTCTCCCAGAAGGAATGGATTGATAGATTTTGATTAAAGTAAGGGTGGAAGGAAATCTGTAGCT
GGATTTACCACAAGTGACATCTAGAAACTATAGTTCACAGGACAGAGCAGAGCCATGGAGACTAAGCATTGACTACCTTGAGTTCTCCTA
GTGAGGAGTTCTGGTATAAAATTTAAGATTACTACCAGTAACCAACTTAAAGCAAACTATAGGGGTCCCTAATTTTGGATTTTTCCTTAA
GTGTAAGAAACAATGCTTCAAATGTTAAGAAATAACAGTCTGGGCAAAGAACGCATATTCTATAGGAAGCCAGGTTTACAATAGGTAAGA
ATAAACTGTATTAAGTAGATGTAATGACTAGAAAGCTGCTTTGCTCCCTATATTGAGAAATTGTGGACATGGTATGTGTTATCCAAAGAA
CATTGGGCTAGAAGATAGATTTCTATCCTTAGCTTTGGCATTATTGACTGGATTGACTTGAACAAGTCACTTAACTTCTACAAGCTTGTT
TCCTTATTTGTCAAATTAGATTACACTAGGAAACGATTCTCGAACATGTTTTAACCTTACAACTCTTTGTTCAAATAAATCTTTCAATGA

>74084_74084_10_RIF1-PDE11A_RIF1_chr2_152318980_ENST00000453091_PDE11A_chr2_178592900_ENST00000358450_length(amino acids)=1478AA_BP=1141
MGAEGQRRREPCPDLPRVADMTARGQSPLAPLLETLEDPSASHGGQTDAYLTLTSRMTGEEGKEVITEIEKKLPRLYKVLKTHISSQNSE
LSSAALQALGFCLYNPKITSELSEANALELLSKLNDTIKNSDKNVRTRALWVISKQTFPSEVVGKMVSSIIDSLEILFNKGETHSAVVDF
EALNVIVRLIEQAPIQMGEEAVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEIASITEQLMTTKLISELQKLFMSKNETYVL
KLWPLFVKLLGRTLHRSGSFINSLLQLEELGFRSGAPMIKKIAFIAWKSLIDNFALNPDILCSAKRLKLLMQPLSSIHVRTETLALTKLE
VWWYLLMRLGPHLPANFEQVCVPLIQSTISIDSNASPQGNSCHVATSPGLNPMTPVHKGASSPYGAPGTPRMNLSSNLGGMATIPSIQLL
GLEMLLHFLLGPEALSFAKQNKLVLSLEPLEHPLISSPSFFSKHANTLITAVHDSFVAVGKDAPDVVVSAIWKELISLVKSVTESGNKKE
KPGSEVLTLLLKSLESIVKSEVFPVSKTLVLMEITIKGLPQKVLGSPAYQVANMDILNGTPALFLIQLIFNNFLECGVSDERFFLSLESL
VGCVLSGPTSPLAFSDSVLNVINQNAKQLENKEHLWKMWSVIVTPLTELINQTNEVNQGDALEHNFSAIYGALTLPVNHIFSEQRFPVAT
MKTLLRTWSELYRAFARCAALVATAEENLCCEELSSKIMSSLEDEGFSNLLFVDRIIYIITVMVDCIDFSPYNIKYQPKVKSPQRPSDWS
KKKNEPLGKLTSLFKLIVKVIYSFHTLSFKEAHSDTLFTIGNSITGIISSVLGHISLPSMIRKIFATLTRPLALFYENSKLDEVPKVYSC
LNNKLEKLLGEIIACLQFSYTGTYDSELLEQLSPLLCIIFLHKNKQIRKQSAQFWNATFAKVMMLVYPEELKPVLTQAKQKFLLLLPGLE
TVEMMEESSGPYSDGTENSQLNVKISGMERKSNGKRDSFLAQTKNKKENMKPAAKLKLESSSLKVKGEILLEEEKSTDFVFIPPEGKDAK
ERILTDHQKEVLKTKRCDIPAMYNNLDVSQDTLFTQYSQEEPMEIPTLTRKPKEDSKMMITAANIPLVSELAIDDIHFDDFSLDVDAMIT
AALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAF
QAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRD
IFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPML

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RIF1-PDE11A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneRIF1chr2:152318980chr2:178592900ENST00000243326+28351924_24721121.02473.0condensed chromosomes in telophase
HgeneRIF1chr2:152318980chr2:178592900ENST00000428287+29351924_24721121.02447.0condensed chromosomes in telophase
HgeneRIF1chr2:152318980chr2:178592900ENST00000430328+28341924_24721121.02447.0condensed chromosomes in telophase
HgeneRIF1chr2:152318980chr2:178592900ENST00000444746+29361924_24721121.02473.0condensed chromosomes in telophase
HgeneRIF1chr2:152318980chr2:178592900ENST00000453091+29351924_24721121.02447.0condensed chromosomes in telophase
HgeneRIF1chr2:152318980chr2:178592900ENST00000243326+28352170_24461121.02473.0ERCC6
HgeneRIF1chr2:152318980chr2:178592900ENST00000428287+29352170_24461121.02447.0ERCC6
HgeneRIF1chr2:152318980chr2:178592900ENST00000430328+28342170_24461121.02447.0ERCC6
HgeneRIF1chr2:152318980chr2:178592900ENST00000444746+29362170_24461121.02473.0ERCC6
HgeneRIF1chr2:152318980chr2:178592900ENST00000453091+29352170_24461121.02447.0ERCC6


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RIF1-PDE11A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RIF1-PDE11A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource