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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RIMKLB-SETD8 (FusionGDB2 ID:74120)

Fusion Gene Summary for RIMKLB-SETD8

check button Fusion gene summary
Fusion gene informationFusion gene name: RIMKLB-SETD8
Fusion gene ID: 74120
HgeneTgene
Gene symbol

RIMKLB

SETD8

Gene ID

57494

387893

Gene nameribosomal modification protein rimK like family member Blysine methyltransferase 5A
SynonymsFAM80B|NAAGS|NAAGS-IPR-Set7|PR/SET07|SET07|SET8|SETD8
Cytomap

12p13.31

12q24.31

Type of geneprotein-codingprotein-coding
Descriptionbeta-citrylglutamate synthase BN-acetyl-aspartyl-glutamate synthetase BN-acetyl-aspartylglutamate synthetase BN-acetylaspartyl-glutamate synthetase BNAAG synthetase Bbeta-citryl-glutamate synthase Bfamily with sequence similarity 80, member BribosoN-lysine methyltransferase KMT5AH4-K20-HMTase KMT5AH4-K20-HMTase SETD8H4-K20-specific histone methyltransferaseH4K20-specific histone methyltransferase splice variant Set8bN-lysine methyltransferase SETD8PR/SET domain containing protein 8PR/SET dom
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000299673, ENST00000357529, 
ENST00000535829, ENST00000538135, 
ENST00000330479, ENST00000402868, 
ENST00000478781, 
Fusion gene scores* DoF score10 X 8 X 6=4802 X 4 X 2=16
# samples 114
** MAII scorelog2(11/480*10)=-2.12553088208386
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RIMKLB [Title/Abstract] AND SETD8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRIMKLB(8906689)-SETD8(123873980), # samples:2
Anticipated loss of major functional domain due to fusion event.RIMKLB-SETD8 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
RIMKLB-SETD8 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSETD8

GO:0018026

peptidyl-lysine monomethylation

17707234

TgeneSETD8

GO:0045892

negative regulation of transcription, DNA-templated

18474616


check buttonFusion gene breakpoints across RIMKLB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SETD8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-B5-A5OE-01ARIMKLBchr12

8906689

-SETD8chr12

123873980

+
ChimerDB4UCECTCGA-B5-A5OE-01ARIMKLBchr12

8906689

+SETD8chr12

123873980

+
ChimerDB4UCECTCGA-B5-A5OERIMKLBchr12

8906689

+SETD8chr12

123875176

+


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Fusion Gene ORF analysis for RIMKLB-SETD8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000299673ENST00000330479RIMKLBchr12

8906689

+SETD8chr12

123873980

+
3UTR-3CDSENST00000299673ENST00000330479RIMKLBchr12

8906689

+SETD8chr12

123875176

+
3UTR-3CDSENST00000299673ENST00000402868RIMKLBchr12

8906689

+SETD8chr12

123873980

+
3UTR-3CDSENST00000299673ENST00000402868RIMKLBchr12

8906689

+SETD8chr12

123875176

+
3UTR-3UTRENST00000299673ENST00000478781RIMKLBchr12

8906689

+SETD8chr12

123875176

+
3UTR-intronENST00000299673ENST00000478781RIMKLBchr12

8906689

+SETD8chr12

123873980

+
5CDS-3UTRENST00000357529ENST00000478781RIMKLBchr12

8906689

+SETD8chr12

123875176

+
5CDS-3UTRENST00000535829ENST00000478781RIMKLBchr12

8906689

+SETD8chr12

123875176

+
5CDS-3UTRENST00000538135ENST00000478781RIMKLBchr12

8906689

+SETD8chr12

123875176

+
5CDS-intronENST00000357529ENST00000478781RIMKLBchr12

8906689

+SETD8chr12

123873980

+
5CDS-intronENST00000535829ENST00000478781RIMKLBchr12

8906689

+SETD8chr12

123873980

+
5CDS-intronENST00000538135ENST00000478781RIMKLBchr12

8906689

+SETD8chr12

123873980

+
Frame-shiftENST00000357529ENST00000330479RIMKLBchr12

8906689

+SETD8chr12

123875176

+
Frame-shiftENST00000357529ENST00000402868RIMKLBchr12

8906689

+SETD8chr12

123875176

+
Frame-shiftENST00000535829ENST00000330479RIMKLBchr12

8906689

+SETD8chr12

123875176

+
Frame-shiftENST00000535829ENST00000402868RIMKLBchr12

8906689

+SETD8chr12

123875176

+
Frame-shiftENST00000538135ENST00000330479RIMKLBchr12

8906689

+SETD8chr12

123875176

+
Frame-shiftENST00000538135ENST00000402868RIMKLBchr12

8906689

+SETD8chr12

123875176

+
In-frameENST00000357529ENST00000330479RIMKLBchr12

8906689

+SETD8chr12

123873980

+
In-frameENST00000357529ENST00000402868RIMKLBchr12

8906689

+SETD8chr12

123873980

+
In-frameENST00000535829ENST00000330479RIMKLBchr12

8906689

+SETD8chr12

123873980

+
In-frameENST00000535829ENST00000402868RIMKLBchr12

8906689

+SETD8chr12

123873980

+
In-frameENST00000538135ENST00000330479RIMKLBchr12

8906689

+SETD8chr12

123873980

+
In-frameENST00000538135ENST00000402868RIMKLBchr12

8906689

+SETD8chr12

123873980

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000535829RIMKLBchr128906689+ENST00000330479SETD8chr12123873980+378411514452199584
ENST00000535829RIMKLBchr128906689+ENST00000402868SETD8chr12123873980+385511514452199584
ENST00000357529RIMKLBchr128906689+ENST00000330479SETD8chr12123873980+4592195912533007584
ENST00000357529RIMKLBchr128906689+ENST00000402868SETD8chr12123873980+4663195912533007584
ENST00000538135RIMKLBchr128906689+ENST00000330479SETD8chr12123873980+415515228162570584
ENST00000538135RIMKLBchr128906689+ENST00000402868SETD8chr12123873980+422615228162570584

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000535829ENST00000330479RIMKLBchr128906689+SETD8chr12123873980+0.0004017540.9995982
ENST00000535829ENST00000402868RIMKLBchr128906689+SETD8chr12123873980+0.0004268720.9995732
ENST00000357529ENST00000330479RIMKLBchr128906689+SETD8chr12123873980+0.0003752130.9996247
ENST00000357529ENST00000402868RIMKLBchr128906689+SETD8chr12123873980+0.0003984660.99960154
ENST00000538135ENST00000330479RIMKLBchr128906689+SETD8chr12123873980+0.0003478840.99965215
ENST00000538135ENST00000402868RIMKLBchr128906689+SETD8chr12123873980+0.0003747090.9996253

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Fusion Genomic Features for RIMKLB-SETD8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RIMKLBchr128906689+SETD8chr12123873979+0.0046947810.9953053
RIMKLBchr128906689+SETD8chr12123875176+0.0032923520.9967077
RIMKLBchr128906689+SETD8chr12123873979+0.0046947810.9953053
RIMKLBchr128906689+SETD8chr12123875176+0.0032923520.9967077

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for RIMKLB-SETD8


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:8906689/chr12:123873980)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRIMKLBchr12:8906689chr12:123873980ENST00000357529+67193_203232387.0Nucleotide bindingATP
HgeneRIMKLBchr12:8906689chr12:123873980ENST00000535829+56193_203232387.0Nucleotide bindingATP
HgeneRIMKLBchr12:8906689chr12:123873980ENST00000538135+56193_203232387.0Nucleotide bindingATP
TgeneSETD8chr12:8906689chr12:123873980ENST0000033047909134_1633368.0Coiled coilOntology_term=ECO:0000255
TgeneSETD8chr12:8906689chr12:123873980ENST0000040286808134_1633353.0Coiled coilOntology_term=ECO:0000255
TgeneSETD8chr12:8906689chr12:123873980ENST000003304790929_323368.0Compositional biasNote=Poly-Arg
TgeneSETD8chr12:8906689chr12:123873980ENST00000330479096_673368.0Compositional biasNote=Ala-rich
TgeneSETD8chr12:8906689chr12:123873980ENST000004028680829_323353.0Compositional biasNote=Poly-Arg
TgeneSETD8chr12:8906689chr12:123873980ENST00000402868086_673353.0Compositional biasNote=Ala-rich
TgeneSETD8chr12:8906689chr12:123873980ENST0000033047909257_3783368.0DomainSET
TgeneSETD8chr12:8906689chr12:123873980ENST0000040286808257_3783353.0DomainSET
TgeneSETD8chr12:8906689chr12:123873980ENST0000033047909267_2693368.0RegionNote=S-adenosyl-L-methionine binding
TgeneSETD8chr12:8906689chr12:123873980ENST0000033047909339_3403368.0RegionNote=S-adenosyl-L-methionine binding
TgeneSETD8chr12:8906689chr12:123873980ENST0000040286808267_2693353.0RegionNote=S-adenosyl-L-methionine binding
TgeneSETD8chr12:8906689chr12:123873980ENST0000040286808339_3403353.0RegionNote=S-adenosyl-L-methionine binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRIMKLBchr12:8906689chr12:123873980ENST00000357529+67119_304232387.0DomainATP-grasp
HgeneRIMKLBchr12:8906689chr12:123873980ENST00000535829+56119_304232387.0DomainATP-grasp
HgeneRIMKLBchr12:8906689chr12:123873980ENST00000538135+56119_304232387.0DomainATP-grasp


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Fusion Gene Sequence for RIMKLB-SETD8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>74120_74120_1_RIMKLB-SETD8_RIMKLB_chr12_8906689_ENST00000357529_SETD8_chr12_123873980_ENST00000330479_length(transcript)=4592nt_BP=1959nt
GGTCTGAGGGAGCGGGGCGGTCTCCGCCGGCGTCGCGCGCGCTGTGTGTGAGCGGGGTCGCGCGCGCGCGCGGCAGGCGAGTGAGGGAAC
GAGGAGCGGCCGGGTGTGAGTGTGTGGGAGTGAGAGTGTGTGGGAGTGGGGTGAGGGAGAAGCTGACGGGACGCGAGGCTGTGAGAAACT
GGGCGAGTGTGCGAGGACGCCCGGCCAGCCTGCGGGAGCCGCAGTCGGCGGAGGAGAAAGGAGGCGGCTCCCGGTATCCCGACCCCCTCC
CCCTCCTCTCCTTCCCCCACTTCCAGCCGCCCGGCGGCCCGCGCTTCCTCGAAGGCCCCAGCCCGGCTCAGTCGGCCGAGAGCGAGGGAG
GAGCCCCCCGACCCAGGTGCTGGAGTCTGCTTGTCAGGGAGGGGGGCAGTCTGTGATTCTGAGAACAGAGCCAAGAAGGGGAACAGCAAA
TTCAGTCACAGACAATCCTCCACTCGGTCAAGAGCCACTTTTCTCTTCCTGCCTTGCCCCCCCGCAGGGGGTAAGGAACTGAGCGTTTAA
TCTTTAGCCGGTTGGCTACCAGCTAAAATTCTACTTATCTTAGTTTCTAGTGGATAGCTTTCTTATTTTGCCCATGTTTTCTTAGAATCC
CTGTTTAATATACTTTTGTCAGTAGTAGTATCTAGGAGTAGCAGGGAGAGTGACAATAAATTAGCCCCTTCTTTTTTCCCTTGTCATTCA
GGCCCCTTTTCCTCTCCAGAGGGAAATTACCAGTAAACTCTTCTAAATCTTCCACCCCTTCTCAGTCATACTGTGAAGAAACACACTAAA
GTGGACATTATTTGACCAGTGAACACGAACCCAGCTTCAGGCATTGGTTTGTTGTGGCACATGGAGAAACATCTCTTTTAAAATATCTCC
CAATTACCCTTTTCACAATTTGTATCCACCTAGGATTTGCTGCTGGGGTAAGTCACTAGATTTATTTCTCAAAGCTCCCCTCTCTATGAG
CTGAAAGACTGACCAACCATGAACACTAGTAGGGGATGGGGAAAGGGGACAGAGCAGAGCCAGTTGTTCCACACTTTGGGAAGCAGGAGT
AGCTTTTATCATCTTCCTCTGGGGAGCAGGCATAGAGACATAAACTGAGTGAAAATGGGTGGAGGAAGAACTTCTATACCCACGAACAAC
ATGTGAAGAGAGAGAACCAAACATAAAGTAAGGAGGGTAGACGTTACATCCAAGAGGAAATAATCCAGGCAAGGAAGCACAAGCTGATCA
AGATGTGTAGTTCTGTGGCTGCCAAGTTGTGGTTTTTGACAGATCGTCGCATCAGGGAAGACTATCCTCAAAAAGAGATTTTACGAGCAT
TGAAGGCCAAATGTTGTGAGGAGGAACTGGACTTTAGGGCTGTGGTGATGGATGAGGTGGTGCTGACAATCGAGCAAGGAAACCTGGGTC
TGCGGATCAATGGAGAGCTAATCACTGCCTACCCACAAGTGGTGGTAGTCAGAGTACCAACCCCTTGGGTGCAAAGTGATAGTGACATCA
CTGTTTTGCGCCATCTAGAGAAGATGGGATGTCGGTTAATGAACCGACCTCAAGCCATCCTGAACTGCGTTAATAAGTTCTGGACATTTC
AAGAGTTGGCTGGCCATGGTGTTCCTCTGCCGGATACTTTCTCTTATGGTGGCCACGAAAATTTTGCTAAAATGATTGATGAGGCTGAAG
TTCTGGAGTTCCCAATGGTAGTAAAGAATACGCGGGGTCACAGAGGTAAAGCTGTTTTCTTGGCTCGAGATAAGCACCATTTGGCTGATC
TAAGCCATCTTATTCGCCATGAAGCGCCATACCTGTTCCAGAAGTATGTTAAAGAGTCTCATGGACGGGATGTACGTGTCATTGTCGTGG
GAGGCCGTGTGGTTGGCACCATGTTACGTTGTTCAACAGATGGGAGAATGCAAAGCAACTGCTCATTAGGCAGGAAGATGTCCAAGCCCC
GCGCGGTGGAGGCGGCGGCGGCGGCGGCGGCGGTGGCAGCGACGGCCCCGGGCCCGGAGATGGTGGAGCGGAGGGGCCCGGGGAGGCCCC
GCACCGACGGGGAGAACGTATTTACCGGGCAGTCAAAGATCTATTCCTACATGAGCCCGAACAAATGCTCTGGAATGCGTTTCCCCCTTC
AGGAAGAGAACTCAGTTACACATCACGAAGTCAAATGCCAGGGGAAACCATTAGCCGGAATCTACAGGAAACGAGAAGAGAAAAGAAATG
CTGGGAACGCAGTACGGAGCGCCATGAAGTCCGAGGAACAGAAGATCAAAGACGCCAGGAAAGGTCCCCTGGTACCTTTTCCAAACCAAA
AATCTGAAGCAGCAGAACCTCCAAAAACTCCACCCTCATCTTGTGATTCCACCAATGCAGCCATCGCCAAGCAAGCCCTGAAAAAGCCCA
TCAAGGGCAAACAGGCCCCCCGAAAAAAAGCTCAAGGAAAAACGCAACAGAATCGCAAACTTACGGATTTCTACCCTGTCCGAAGGAGCT
CCAGGAAGAGCAAAGCCGAGCTGCAGTCTGAAGAAAGGAAAAGAATAGATGAATTGATTGAAAGTGGGAAGGAAGAAGGAATGAAGATTG
ACCTCATCGATGGCAAAGGCAGGGGTGTGATTGCCACCAAGCAGTTCTCCCGGGGTGACTTTGTGGTGGAATACCACGGGGACCTCATCG
AGATCACCGACGCCAAGAAACGGGAGGCTCTGTACGCACAGGACCCTTCCACGGGCTGCTACATGTACTATTTTCAGTATCTGAGCAAAA
CCTACTGCGTGGATGCAACTAGAGAGACAAATCGCCTAGGAAGACTGATCAATCACAGCAAATGTGGGAACTGCCAAACCAAACTGCACG
ACATCGACGGCGTACCTCACCTCATCCTCATCGCCTCCCGAGACATCGCGGCTGGGGAGGAGCTCCTGTATGACTATGGGGACCGCAGCA
AGGCTTCCATTGAAGCCCACCCGTGGCTGAAGCATTAACCGGTGGGCCCCGTGCCCTCCCCGCCCCACTTTCCCTTCTTCAAAGGACAAA
GTGCCCTCAAAGGGAATTGAATTTTTTTTTTACACACTTAATCTTAGCGGATTACTTCAGATGTTTTTAAAAAGTATATTAAGATGCCTT
TTCACTGTAGTATTTAAATATCTGTTACAGGTTTCCAAGGTGGACTTGAACAGATGGCCTTATATTACCAAAACTTTTATATTCTAGTTG
TTTTTGTACTTTTTTTGCATACAAGCCGAACGTTTGTGCTTCCCGTGCATGCAGTCAAAGACTCAGCACAGGTTTTAGAGGAAATAGTCA
AACATGAACTAGGAAGCCAGGTGAGTCTCCTTTCTCCAGTGGAAGAGCCGGGACCTTCCCCCTGCACCCCCGACATCCAGGGACGGGGTG
TGAGGAAGACGCTGCCTCCCAATGGCCTGGACGGGATGTTTCCAAGCTCTTGTTCCCCTAACGTCTCAACAGGCGCTCACTGAAGTGTAT
GAATATTTTTTAAAAAGGTTTTTGCAGTAAGCTAGTCTTCCCCTCTGCTTTCTCGAAAGCTTACTGAGCCCCGGGCCCCAAGCACGGGCC
GGGCATAGATTTCCTCTTCCACAAGCTGCCGCTTTTCTGGGCACCTTGAAGCATCAGGGCGTGAAATCAAACTAGATGTGGGCAGGGAGA
GGGTTGCTTACCTGCCCTGCTGGGGCAGGGTTTCCTGAAACTGGGTTAATTCTTTATAGAAATGTGAACACTGAATTTATTTTAAAAAAT
AATAATAAAAATTTAAAAAAATTAAAAATAAAAAAAACCACAGAAAACAACTTTACATGTATATAGGTCTTGAAGTGAGTGAAGTGGCTG
CTTTTTTTTTTTTTTTTTTTTGCTTTTTTTTGCTTTTTGTAGAAGAGATTGAGAATGGTACTCTAATCAAAAATAAAGTTTTGTAGTGGG
ACCAGAAATTACTTACCTGACATCCACCCCCATTCCCCCTCATCCTGCTGGGGTTGAAAGTTCCAGACCTGCTGTCGAGGCCTTGTGTTT
GTCAGACACCCAGTGTCCTCCTGCAAGGACGCAACTGTGAGCTGAGGTGTGAGCCTAGGAGCACACAGGGCCCGGCAGCCCCCAGGAATC
AAGGATAGGGCTAAGGTTTTCACCTTAACTGTGAAGGCAGGAGGAATAGGTGACTGCTTCCTCCCGCCCTTCACAGAACTGATTCTCACA
CACTGTCCCTTCAGTCCAGGGGGCCGGGGCTCAGGAGCCATGACCTGGTGTCTCCTGCCCACCCTGGTCCCAGGTAAATGTGAATGGAGA
CAGGTATGAGAGGCTGTCCTCGTCTTTGATTCCCCCCCAACCCCACCTCGGGCCTCACGACGGTGCTACCTAAGAAAGTCTTCCCTCCCA
CCCCCCGCTAGCCTGGTCAGTGGTCAGCAAATTGGAAGAGGATCCGATGGGAGTGTAAATGTGAGACACAATGTCTTGATTATACCTGTT
TGTGGTTTAGCTTTGTATTTAAACAAGGAAATAAACTTGAAAATTATTTGTCATCATAAAAATGAAACAAATTAAAATATTTATTGCCAG

>74120_74120_1_RIMKLB-SETD8_RIMKLB_chr12_8906689_ENST00000357529_SETD8_chr12_123873980_ENST00000330479_length(amino acids)=584AA_BP=233
MIKMCSSVAAKLWFLTDRRIREDYPQKEILRALKAKCCEEELDFRAVVMDEVVLTIEQGNLGLRINGELITAYPQVVVVRVPTPWVQSDS
DITVLRHLEKMGCRLMNRPQAILNCVNKFWTFQELAGHGVPLPDTFSYGGHENFAKMIDEAEVLEFPMVVKNTRGHRGKAVFLARDKHHL
ADLSHLIRHEAPYLFQKYVKESHGRDVRVIVVGGRVVGTMLRCSTDGRMQSNCSLGRKMSKPRAVEAAAAAAAVAATAPGPEMVERRGPG
RPRTDGENVFTGQSKIYSYMSPNKCSGMRFPLQEENSVTHHEVKCQGKPLAGIYRKREEKRNAGNAVRSAMKSEEQKIKDARKGPLVPFP
NQKSEAAEPPKTPPSSCDSTNAAIAKQALKKPIKGKQAPRKKAQGKTQQNRKLTDFYPVRRSSRKSKAELQSEERKRIDELIESGKEEGM
KIDLIDGKGRGVIATKQFSRGDFVVEYHGDLIEITDAKKREALYAQDPSTGCYMYYFQYLSKTYCVDATRETNRLGRLINHSKCGNCQTK

--------------------------------------------------------------
>74120_74120_2_RIMKLB-SETD8_RIMKLB_chr12_8906689_ENST00000357529_SETD8_chr12_123873980_ENST00000402868_length(transcript)=4663nt_BP=1959nt
GGTCTGAGGGAGCGGGGCGGTCTCCGCCGGCGTCGCGCGCGCTGTGTGTGAGCGGGGTCGCGCGCGCGCGCGGCAGGCGAGTGAGGGAAC
GAGGAGCGGCCGGGTGTGAGTGTGTGGGAGTGAGAGTGTGTGGGAGTGGGGTGAGGGAGAAGCTGACGGGACGCGAGGCTGTGAGAAACT
GGGCGAGTGTGCGAGGACGCCCGGCCAGCCTGCGGGAGCCGCAGTCGGCGGAGGAGAAAGGAGGCGGCTCCCGGTATCCCGACCCCCTCC
CCCTCCTCTCCTTCCCCCACTTCCAGCCGCCCGGCGGCCCGCGCTTCCTCGAAGGCCCCAGCCCGGCTCAGTCGGCCGAGAGCGAGGGAG
GAGCCCCCCGACCCAGGTGCTGGAGTCTGCTTGTCAGGGAGGGGGGCAGTCTGTGATTCTGAGAACAGAGCCAAGAAGGGGAACAGCAAA
TTCAGTCACAGACAATCCTCCACTCGGTCAAGAGCCACTTTTCTCTTCCTGCCTTGCCCCCCCGCAGGGGGTAAGGAACTGAGCGTTTAA
TCTTTAGCCGGTTGGCTACCAGCTAAAATTCTACTTATCTTAGTTTCTAGTGGATAGCTTTCTTATTTTGCCCATGTTTTCTTAGAATCC
CTGTTTAATATACTTTTGTCAGTAGTAGTATCTAGGAGTAGCAGGGAGAGTGACAATAAATTAGCCCCTTCTTTTTTCCCTTGTCATTCA
GGCCCCTTTTCCTCTCCAGAGGGAAATTACCAGTAAACTCTTCTAAATCTTCCACCCCTTCTCAGTCATACTGTGAAGAAACACACTAAA
GTGGACATTATTTGACCAGTGAACACGAACCCAGCTTCAGGCATTGGTTTGTTGTGGCACATGGAGAAACATCTCTTTTAAAATATCTCC
CAATTACCCTTTTCACAATTTGTATCCACCTAGGATTTGCTGCTGGGGTAAGTCACTAGATTTATTTCTCAAAGCTCCCCTCTCTATGAG
CTGAAAGACTGACCAACCATGAACACTAGTAGGGGATGGGGAAAGGGGACAGAGCAGAGCCAGTTGTTCCACACTTTGGGAAGCAGGAGT
AGCTTTTATCATCTTCCTCTGGGGAGCAGGCATAGAGACATAAACTGAGTGAAAATGGGTGGAGGAAGAACTTCTATACCCACGAACAAC
ATGTGAAGAGAGAGAACCAAACATAAAGTAAGGAGGGTAGACGTTACATCCAAGAGGAAATAATCCAGGCAAGGAAGCACAAGCTGATCA
AGATGTGTAGTTCTGTGGCTGCCAAGTTGTGGTTTTTGACAGATCGTCGCATCAGGGAAGACTATCCTCAAAAAGAGATTTTACGAGCAT
TGAAGGCCAAATGTTGTGAGGAGGAACTGGACTTTAGGGCTGTGGTGATGGATGAGGTGGTGCTGACAATCGAGCAAGGAAACCTGGGTC
TGCGGATCAATGGAGAGCTAATCACTGCCTACCCACAAGTGGTGGTAGTCAGAGTACCAACCCCTTGGGTGCAAAGTGATAGTGACATCA
CTGTTTTGCGCCATCTAGAGAAGATGGGATGTCGGTTAATGAACCGACCTCAAGCCATCCTGAACTGCGTTAATAAGTTCTGGACATTTC
AAGAGTTGGCTGGCCATGGTGTTCCTCTGCCGGATACTTTCTCTTATGGTGGCCACGAAAATTTTGCTAAAATGATTGATGAGGCTGAAG
TTCTGGAGTTCCCAATGGTAGTAAAGAATACGCGGGGTCACAGAGGTAAAGCTGTTTTCTTGGCTCGAGATAAGCACCATTTGGCTGATC
TAAGCCATCTTATTCGCCATGAAGCGCCATACCTGTTCCAGAAGTATGTTAAAGAGTCTCATGGACGGGATGTACGTGTCATTGTCGTGG
GAGGCCGTGTGGTTGGCACCATGTTACGTTGTTCAACAGATGGGAGAATGCAAAGCAACTGCTCATTAGGCAGGAAGATGTCCAAGCCCC
GCGCGGTGGAGGCGGCGGCGGCGGCGGCGGCGGTGGCAGCGACGGCCCCGGGCCCGGAGATGGTGGAGCGGAGGGGCCCGGGGAGGCCCC
GCACCGACGGGGAGAACGTATTTACCGGGCAGTCAAAGATCTATTCCTACATGAGCCCGAACAAATGCTCTGGAATGCGTTTCCCCCTTC
AGGAAGAGAACTCAGTTACACATCACGAAGTCAAATGCCAGGGGAAACCATTAGCCGGAATCTACAGGAAACGAGAAGAGAAAAGAAATG
CTGGGAACGCAGTACGGAGCGCCATGAAGTCCGAGGAACAGAAGATCAAAGACGCCAGGAAAGGTCCCCTGGTACCTTTTCCAAACCAAA
AATCTGAAGCAGCAGAACCTCCAAAAACTCCACCCTCATCTTGTGATTCCACCAATGCAGCCATCGCCAAGCAAGCCCTGAAAAAGCCCA
TCAAGGGCAAACAGGCCCCCCGAAAAAAAGCTCAAGGAAAAACGCAACAGAATCGCAAACTTACGGATTTCTACCCTGTCCGAAGGAGCT
CCAGGAAGAGCAAAGCCGAGCTGCAGTCTGAAGAAAGGAAAAGAATAGATGAATTGATTGAAAGTGGGAAGGAAGAAGGAATGAAGATTG
ACCTCATCGATGGCAAAGGCAGGGGTGTGATTGCCACCAAGCAGTTCTCCCGGGGTGACTTTGTGGTGGAATACCACGGGGACCTCATCG
AGATCACCGACGCCAAGAAACGGGAGGCTCTGTACGCACAGGACCCTTCCACGGGCTGCTACATGTACTATTTTCAGTATCTGAGCAAAA
CCTACTGCGTGGATGCAACTAGAGAGACAAATCGCCTAGGAAGACTGATCAATCACAGCAAATGTGGGAACTGCCAAACCAAACTGCACG
ACATCGACGGCGTACCTCACCTCATCCTCATCGCCTCCCGAGACATCGCGGCTGGGGAGGAGCTCCTGTATGACTATGGGGACCGCAGCA
AGGCTTCCATTGAAGCCCACCCGTGGCTGAAGCATTAACCGGTGGGCCCCGTGCCCTCCCCGCCCCACTTTCCCTTCTTCAAAGGACAAA
GTGCCCTCAAAGGGAATTGAATTTTTTTTTTACACACTTAATCTTAGCGGATTACTTCAGATGTTTTTAAAAAGTATATTAAGATGCCTT
TTCACTGTAGTATTTAAATATCTGTTACAGGTTTCCAAGGTGGACTTGAACAGATGGCCTTATATTACCAAAACTTTTATATTCTAGTTG
TTTTTGTACTTTTTTTGCATACAAGCCGAACGTTTGTGCTTCCCGTGCATGCAGTCAAAGACTCAGCACAGGTTTTAGAGGAAATAGTCA
AACATGAACTAGGAAGCCAGGTGAGTCTCCTTTCTCCAGTGGAAGAGCCGGGACCTTCCCCCTGCACCCCCGACATCCAGGGACGGGGTG
TGAGGAAGACGCTGCCTCCCAATGGCCTGGACGGGATGTTTCCAAGCTCTTGTTCCCCTAACGTCTCAACAGGCGCTCACTGAAGTGTAT
GAATATTTTTTAAAAAGGTTTTTGCAGTAAGCTAGTCTTCCCCTCTGCTTTCTCGAAAGCTTACTGAGCCCCGGGCCCCAAGCACGGGCC
GGGCATAGATTTCCTCTTCCACAAGCTGCCGCTTTTCTGGGCACCTTGAAGCATCAGGGCGTGAAATCAAACTAGATGTGGGCAGGGAGA
GGGTTGCTTACCTGCCCTGCTGGGGCAGGGTTTCCTGAAACTGGGTTAATTCTTTATAGAAATGTGAACACTGAATTTATTTTAAAAAAT
AATAATAAAAATTTAAAAAAATTAAAAATAAAAAAAACCACAGAAAACAACTTTACATGTATATAGGTCTTGAAGTGAGTGAAGTGGCTG
CTTTTTTTTTTTTTTTTTTTTGCTTTTTTTTGCTTTTTGTAGAAGAGATTGAGAATGGTACTCTAATCAAAAATAAAGTTTTGTAGTGGG
ACCAGAAATTACTTACCTGACATCCACCCCCATTCCCCCTCATCCTGCTGGGGTTGAAAGTTCCAGACCTGCTGTCGAGGCCTTGTGTTT
GTCAGACACCCAGTGTCCTCCTGCAAGGACGCAACTGTGAGCTGAGGTGTGAGCCTAGGAGCCCAGGACCCCTGACCCCGGCCGCTGCTG
CCAGCCTCAGAAAGGCACCCAGGTGTGCAGGGGAGCACACAGGGCCCGGCAGCCCCCAGGAATCAAGGATAGGGCTAAGGTTTTCACCTT
AACTGTGAAGGCAGGAGGAATAGGTGACTGCTTCCTCCCGCCCTTCACAGAACTGATTCTCACACACTGTCCCTTCAGTCCAGGGGGCCG
GGGCTCAGGAGCCATGACCTGGTGTCTCCTGCCCACCCTGGTCCCAGGTAAATGTGAATGGAGACAGGTATGAGAGGCTGTCCTCGTCTT
TGATTCCCCCCCAACCCCACCTCGGGCCTCACGACGGTGCTACCTAAGAAAGTCTTCCCTCCCACCCCCCGCTAGCCTGGTCAGTGGTCA
GCAAATTGGAAGAGGATCCGATGGGAGTGTAAATGTGAGACACAATGTCTTGATTATACCTGTTTGTGGTTTAGCTTTGTATTTAAACAA

>74120_74120_2_RIMKLB-SETD8_RIMKLB_chr12_8906689_ENST00000357529_SETD8_chr12_123873980_ENST00000402868_length(amino acids)=584AA_BP=233
MIKMCSSVAAKLWFLTDRRIREDYPQKEILRALKAKCCEEELDFRAVVMDEVVLTIEQGNLGLRINGELITAYPQVVVVRVPTPWVQSDS
DITVLRHLEKMGCRLMNRPQAILNCVNKFWTFQELAGHGVPLPDTFSYGGHENFAKMIDEAEVLEFPMVVKNTRGHRGKAVFLARDKHHL
ADLSHLIRHEAPYLFQKYVKESHGRDVRVIVVGGRVVGTMLRCSTDGRMQSNCSLGRKMSKPRAVEAAAAAAAVAATAPGPEMVERRGPG
RPRTDGENVFTGQSKIYSYMSPNKCSGMRFPLQEENSVTHHEVKCQGKPLAGIYRKREEKRNAGNAVRSAMKSEEQKIKDARKGPLVPFP
NQKSEAAEPPKTPPSSCDSTNAAIAKQALKKPIKGKQAPRKKAQGKTQQNRKLTDFYPVRRSSRKSKAELQSEERKRIDELIESGKEEGM
KIDLIDGKGRGVIATKQFSRGDFVVEYHGDLIEITDAKKREALYAQDPSTGCYMYYFQYLSKTYCVDATRETNRLGRLINHSKCGNCQTK

--------------------------------------------------------------
>74120_74120_3_RIMKLB-SETD8_RIMKLB_chr12_8906689_ENST00000535829_SETD8_chr12_123873980_ENST00000330479_length(transcript)=3784nt_BP=1151nt
AGCAAGCGGGCGGGCGGCGTTCGGTCTGAGGGAGCGGGGCGGTCTCCGCCGGCGTCGCGCGCGCTGTGTGTGAGCGGGGTCGCGCGCGCG
CGCGGCAGGCGAGTGAGGGAACGAGGAGCGGCCGGGTGTGAGTGTGTGGGAGTGAGAGTGTGTGGGAGTGGGGTGAGGGAGAAGCTGACG
GGACGCGAGGCTGTGAGAAACTGGGCGAGTGTGCGAGGACGCCCGGCCAGCCTGCGGGAGCCGCAGTCGGCGGAGGAGAAAGGAGGCGGC
TCCCGGTATCCCGACCCCCTCCCCCTCCTCTCCTTCCCCCACTTCCAGCCGCCCGGCGGCCCGCGCTTCCTCGAAGGCCCCAGCCCGGCT
CAGTCGGCCGAGAGCGAGGGAGGAGCCCCCCGACCCAGGTAGACGTTACATCCAAGAGGAAATAATCCAGGCAAGGAAGCACAAGCTGAT
CAAGATGTGTAGTTCTGTGGCTGCCAAGTTGTGGTTTTTGACAGATCGTCGCATCAGGGAAGACTATCCTCAAAAAGAGATTTTACGAGC
ATTGAAGGCCAAATGTTGTGAGGAGGAACTGGACTTTAGGGCTGTGGTGATGGATGAGGTGGTGCTGACAATCGAGCAAGGAAACCTGGG
TCTGCGGATCAATGGAGAGCTAATCACTGCCTACCCACAAGTGGTGGTAGTCAGAGTACCAACCCCTTGGGTGCAAAGTGATAGTGACAT
CACTGTTTTGCGCCATCTAGAGAAGATGGGATGTCGGTTAATGAACCGACCTCAAGCCATCCTGAACTGCGTTAATAAGTTCTGGACATT
TCAAGAGTTGGCTGGCCATGGTGTTCCTCTGCCGGATACTTTCTCTTATGGTGGCCACGAAAATTTTGCTAAAATGATTGATGAGGCTGA
AGTTCTGGAGTTCCCAATGGTAGTAAAGAATACGCGGGGTCACAGAGGTAAAGCTGTTTTCTTGGCTCGAGATAAGCACCATTTGGCTGA
TCTAAGCCATCTTATTCGCCATGAAGCGCCATACCTGTTCCAGAAGTATGTTAAAGAGTCTCATGGACGGGATGTACGTGTCATTGTCGT
GGGAGGCCGTGTGGTTGGCACCATGTTACGTTGTTCAACAGATGGGAGAATGCAAAGCAACTGCTCATTAGGCAGGAAGATGTCCAAGCC
CCGCGCGGTGGAGGCGGCGGCGGCGGCGGCGGCGGTGGCAGCGACGGCCCCGGGCCCGGAGATGGTGGAGCGGAGGGGCCCGGGGAGGCC
CCGCACCGACGGGGAGAACGTATTTACCGGGCAGTCAAAGATCTATTCCTACATGAGCCCGAACAAATGCTCTGGAATGCGTTTCCCCCT
TCAGGAAGAGAACTCAGTTACACATCACGAAGTCAAATGCCAGGGGAAACCATTAGCCGGAATCTACAGGAAACGAGAAGAGAAAAGAAA
TGCTGGGAACGCAGTACGGAGCGCCATGAAGTCCGAGGAACAGAAGATCAAAGACGCCAGGAAAGGTCCCCTGGTACCTTTTCCAAACCA
AAAATCTGAAGCAGCAGAACCTCCAAAAACTCCACCCTCATCTTGTGATTCCACCAATGCAGCCATCGCCAAGCAAGCCCTGAAAAAGCC
CATCAAGGGCAAACAGGCCCCCCGAAAAAAAGCTCAAGGAAAAACGCAACAGAATCGCAAACTTACGGATTTCTACCCTGTCCGAAGGAG
CTCCAGGAAGAGCAAAGCCGAGCTGCAGTCTGAAGAAAGGAAAAGAATAGATGAATTGATTGAAAGTGGGAAGGAAGAAGGAATGAAGAT
TGACCTCATCGATGGCAAAGGCAGGGGTGTGATTGCCACCAAGCAGTTCTCCCGGGGTGACTTTGTGGTGGAATACCACGGGGACCTCAT
CGAGATCACCGACGCCAAGAAACGGGAGGCTCTGTACGCACAGGACCCTTCCACGGGCTGCTACATGTACTATTTTCAGTATCTGAGCAA
AACCTACTGCGTGGATGCAACTAGAGAGACAAATCGCCTAGGAAGACTGATCAATCACAGCAAATGTGGGAACTGCCAAACCAAACTGCA
CGACATCGACGGCGTACCTCACCTCATCCTCATCGCCTCCCGAGACATCGCGGCTGGGGAGGAGCTCCTGTATGACTATGGGGACCGCAG
CAAGGCTTCCATTGAAGCCCACCCGTGGCTGAAGCATTAACCGGTGGGCCCCGTGCCCTCCCCGCCCCACTTTCCCTTCTTCAAAGGACA
AAGTGCCCTCAAAGGGAATTGAATTTTTTTTTTACACACTTAATCTTAGCGGATTACTTCAGATGTTTTTAAAAAGTATATTAAGATGCC
TTTTCACTGTAGTATTTAAATATCTGTTACAGGTTTCCAAGGTGGACTTGAACAGATGGCCTTATATTACCAAAACTTTTATATTCTAGT
TGTTTTTGTACTTTTTTTGCATACAAGCCGAACGTTTGTGCTTCCCGTGCATGCAGTCAAAGACTCAGCACAGGTTTTAGAGGAAATAGT
CAAACATGAACTAGGAAGCCAGGTGAGTCTCCTTTCTCCAGTGGAAGAGCCGGGACCTTCCCCCTGCACCCCCGACATCCAGGGACGGGG
TGTGAGGAAGACGCTGCCTCCCAATGGCCTGGACGGGATGTTTCCAAGCTCTTGTTCCCCTAACGTCTCAACAGGCGCTCACTGAAGTGT
ATGAATATTTTTTAAAAAGGTTTTTGCAGTAAGCTAGTCTTCCCCTCTGCTTTCTCGAAAGCTTACTGAGCCCCGGGCCCCAAGCACGGG
CCGGGCATAGATTTCCTCTTCCACAAGCTGCCGCTTTTCTGGGCACCTTGAAGCATCAGGGCGTGAAATCAAACTAGATGTGGGCAGGGA
GAGGGTTGCTTACCTGCCCTGCTGGGGCAGGGTTTCCTGAAACTGGGTTAATTCTTTATAGAAATGTGAACACTGAATTTATTTTAAAAA
ATAATAATAAAAATTTAAAAAAATTAAAAATAAAAAAAACCACAGAAAACAACTTTACATGTATATAGGTCTTGAAGTGAGTGAAGTGGC
TGCTTTTTTTTTTTTTTTTTTTTGCTTTTTTTTGCTTTTTGTAGAAGAGATTGAGAATGGTACTCTAATCAAAAATAAAGTTTTGTAGTG
GGACCAGAAATTACTTACCTGACATCCACCCCCATTCCCCCTCATCCTGCTGGGGTTGAAAGTTCCAGACCTGCTGTCGAGGCCTTGTGT
TTGTCAGACACCCAGTGTCCTCCTGCAAGGACGCAACTGTGAGCTGAGGTGTGAGCCTAGGAGCACACAGGGCCCGGCAGCCCCCAGGAA
TCAAGGATAGGGCTAAGGTTTTCACCTTAACTGTGAAGGCAGGAGGAATAGGTGACTGCTTCCTCCCGCCCTTCACAGAACTGATTCTCA
CACACTGTCCCTTCAGTCCAGGGGGCCGGGGCTCAGGAGCCATGACCTGGTGTCTCCTGCCCACCCTGGTCCCAGGTAAATGTGAATGGA
GACAGGTATGAGAGGCTGTCCTCGTCTTTGATTCCCCCCCAACCCCACCTCGGGCCTCACGACGGTGCTACCTAAGAAAGTCTTCCCTCC
CACCCCCCGCTAGCCTGGTCAGTGGTCAGCAAATTGGAAGAGGATCCGATGGGAGTGTAAATGTGAGACACAATGTCTTGATTATACCTG
TTTGTGGTTTAGCTTTGTATTTAAACAAGGAAATAAACTTGAAAATTATTTGTCATCATAAAAATGAAACAAATTAAAATATTTATTGCC

>74120_74120_3_RIMKLB-SETD8_RIMKLB_chr12_8906689_ENST00000535829_SETD8_chr12_123873980_ENST00000330479_length(amino acids)=584AA_BP=233
MIKMCSSVAAKLWFLTDRRIREDYPQKEILRALKAKCCEEELDFRAVVMDEVVLTIEQGNLGLRINGELITAYPQVVVVRVPTPWVQSDS
DITVLRHLEKMGCRLMNRPQAILNCVNKFWTFQELAGHGVPLPDTFSYGGHENFAKMIDEAEVLEFPMVVKNTRGHRGKAVFLARDKHHL
ADLSHLIRHEAPYLFQKYVKESHGRDVRVIVVGGRVVGTMLRCSTDGRMQSNCSLGRKMSKPRAVEAAAAAAAVAATAPGPEMVERRGPG
RPRTDGENVFTGQSKIYSYMSPNKCSGMRFPLQEENSVTHHEVKCQGKPLAGIYRKREEKRNAGNAVRSAMKSEEQKIKDARKGPLVPFP
NQKSEAAEPPKTPPSSCDSTNAAIAKQALKKPIKGKQAPRKKAQGKTQQNRKLTDFYPVRRSSRKSKAELQSEERKRIDELIESGKEEGM
KIDLIDGKGRGVIATKQFSRGDFVVEYHGDLIEITDAKKREALYAQDPSTGCYMYYFQYLSKTYCVDATRETNRLGRLINHSKCGNCQTK

--------------------------------------------------------------
>74120_74120_4_RIMKLB-SETD8_RIMKLB_chr12_8906689_ENST00000535829_SETD8_chr12_123873980_ENST00000402868_length(transcript)=3855nt_BP=1151nt
AGCAAGCGGGCGGGCGGCGTTCGGTCTGAGGGAGCGGGGCGGTCTCCGCCGGCGTCGCGCGCGCTGTGTGTGAGCGGGGTCGCGCGCGCG
CGCGGCAGGCGAGTGAGGGAACGAGGAGCGGCCGGGTGTGAGTGTGTGGGAGTGAGAGTGTGTGGGAGTGGGGTGAGGGAGAAGCTGACG
GGACGCGAGGCTGTGAGAAACTGGGCGAGTGTGCGAGGACGCCCGGCCAGCCTGCGGGAGCCGCAGTCGGCGGAGGAGAAAGGAGGCGGC
TCCCGGTATCCCGACCCCCTCCCCCTCCTCTCCTTCCCCCACTTCCAGCCGCCCGGCGGCCCGCGCTTCCTCGAAGGCCCCAGCCCGGCT
CAGTCGGCCGAGAGCGAGGGAGGAGCCCCCCGACCCAGGTAGACGTTACATCCAAGAGGAAATAATCCAGGCAAGGAAGCACAAGCTGAT
CAAGATGTGTAGTTCTGTGGCTGCCAAGTTGTGGTTTTTGACAGATCGTCGCATCAGGGAAGACTATCCTCAAAAAGAGATTTTACGAGC
ATTGAAGGCCAAATGTTGTGAGGAGGAACTGGACTTTAGGGCTGTGGTGATGGATGAGGTGGTGCTGACAATCGAGCAAGGAAACCTGGG
TCTGCGGATCAATGGAGAGCTAATCACTGCCTACCCACAAGTGGTGGTAGTCAGAGTACCAACCCCTTGGGTGCAAAGTGATAGTGACAT
CACTGTTTTGCGCCATCTAGAGAAGATGGGATGTCGGTTAATGAACCGACCTCAAGCCATCCTGAACTGCGTTAATAAGTTCTGGACATT
TCAAGAGTTGGCTGGCCATGGTGTTCCTCTGCCGGATACTTTCTCTTATGGTGGCCACGAAAATTTTGCTAAAATGATTGATGAGGCTGA
AGTTCTGGAGTTCCCAATGGTAGTAAAGAATACGCGGGGTCACAGAGGTAAAGCTGTTTTCTTGGCTCGAGATAAGCACCATTTGGCTGA
TCTAAGCCATCTTATTCGCCATGAAGCGCCATACCTGTTCCAGAAGTATGTTAAAGAGTCTCATGGACGGGATGTACGTGTCATTGTCGT
GGGAGGCCGTGTGGTTGGCACCATGTTACGTTGTTCAACAGATGGGAGAATGCAAAGCAACTGCTCATTAGGCAGGAAGATGTCCAAGCC
CCGCGCGGTGGAGGCGGCGGCGGCGGCGGCGGCGGTGGCAGCGACGGCCCCGGGCCCGGAGATGGTGGAGCGGAGGGGCCCGGGGAGGCC
CCGCACCGACGGGGAGAACGTATTTACCGGGCAGTCAAAGATCTATTCCTACATGAGCCCGAACAAATGCTCTGGAATGCGTTTCCCCCT
TCAGGAAGAGAACTCAGTTACACATCACGAAGTCAAATGCCAGGGGAAACCATTAGCCGGAATCTACAGGAAACGAGAAGAGAAAAGAAA
TGCTGGGAACGCAGTACGGAGCGCCATGAAGTCCGAGGAACAGAAGATCAAAGACGCCAGGAAAGGTCCCCTGGTACCTTTTCCAAACCA
AAAATCTGAAGCAGCAGAACCTCCAAAAACTCCACCCTCATCTTGTGATTCCACCAATGCAGCCATCGCCAAGCAAGCCCTGAAAAAGCC
CATCAAGGGCAAACAGGCCCCCCGAAAAAAAGCTCAAGGAAAAACGCAACAGAATCGCAAACTTACGGATTTCTACCCTGTCCGAAGGAG
CTCCAGGAAGAGCAAAGCCGAGCTGCAGTCTGAAGAAAGGAAAAGAATAGATGAATTGATTGAAAGTGGGAAGGAAGAAGGAATGAAGAT
TGACCTCATCGATGGCAAAGGCAGGGGTGTGATTGCCACCAAGCAGTTCTCCCGGGGTGACTTTGTGGTGGAATACCACGGGGACCTCAT
CGAGATCACCGACGCCAAGAAACGGGAGGCTCTGTACGCACAGGACCCTTCCACGGGCTGCTACATGTACTATTTTCAGTATCTGAGCAA
AACCTACTGCGTGGATGCAACTAGAGAGACAAATCGCCTAGGAAGACTGATCAATCACAGCAAATGTGGGAACTGCCAAACCAAACTGCA
CGACATCGACGGCGTACCTCACCTCATCCTCATCGCCTCCCGAGACATCGCGGCTGGGGAGGAGCTCCTGTATGACTATGGGGACCGCAG
CAAGGCTTCCATTGAAGCCCACCCGTGGCTGAAGCATTAACCGGTGGGCCCCGTGCCCTCCCCGCCCCACTTTCCCTTCTTCAAAGGACA
AAGTGCCCTCAAAGGGAATTGAATTTTTTTTTTACACACTTAATCTTAGCGGATTACTTCAGATGTTTTTAAAAAGTATATTAAGATGCC
TTTTCACTGTAGTATTTAAATATCTGTTACAGGTTTCCAAGGTGGACTTGAACAGATGGCCTTATATTACCAAAACTTTTATATTCTAGT
TGTTTTTGTACTTTTTTTGCATACAAGCCGAACGTTTGTGCTTCCCGTGCATGCAGTCAAAGACTCAGCACAGGTTTTAGAGGAAATAGT
CAAACATGAACTAGGAAGCCAGGTGAGTCTCCTTTCTCCAGTGGAAGAGCCGGGACCTTCCCCCTGCACCCCCGACATCCAGGGACGGGG
TGTGAGGAAGACGCTGCCTCCCAATGGCCTGGACGGGATGTTTCCAAGCTCTTGTTCCCCTAACGTCTCAACAGGCGCTCACTGAAGTGT
ATGAATATTTTTTAAAAAGGTTTTTGCAGTAAGCTAGTCTTCCCCTCTGCTTTCTCGAAAGCTTACTGAGCCCCGGGCCCCAAGCACGGG
CCGGGCATAGATTTCCTCTTCCACAAGCTGCCGCTTTTCTGGGCACCTTGAAGCATCAGGGCGTGAAATCAAACTAGATGTGGGCAGGGA
GAGGGTTGCTTACCTGCCCTGCTGGGGCAGGGTTTCCTGAAACTGGGTTAATTCTTTATAGAAATGTGAACACTGAATTTATTTTAAAAA
ATAATAATAAAAATTTAAAAAAATTAAAAATAAAAAAAACCACAGAAAACAACTTTACATGTATATAGGTCTTGAAGTGAGTGAAGTGGC
TGCTTTTTTTTTTTTTTTTTTTTGCTTTTTTTTGCTTTTTGTAGAAGAGATTGAGAATGGTACTCTAATCAAAAATAAAGTTTTGTAGTG
GGACCAGAAATTACTTACCTGACATCCACCCCCATTCCCCCTCATCCTGCTGGGGTTGAAAGTTCCAGACCTGCTGTCGAGGCCTTGTGT
TTGTCAGACACCCAGTGTCCTCCTGCAAGGACGCAACTGTGAGCTGAGGTGTGAGCCTAGGAGCCCAGGACCCCTGACCCCGGCCGCTGC
TGCCAGCCTCAGAAAGGCACCCAGGTGTGCAGGGGAGCACACAGGGCCCGGCAGCCCCCAGGAATCAAGGATAGGGCTAAGGTTTTCACC
TTAACTGTGAAGGCAGGAGGAATAGGTGACTGCTTCCTCCCGCCCTTCACAGAACTGATTCTCACACACTGTCCCTTCAGTCCAGGGGGC
CGGGGCTCAGGAGCCATGACCTGGTGTCTCCTGCCCACCCTGGTCCCAGGTAAATGTGAATGGAGACAGGTATGAGAGGCTGTCCTCGTC
TTTGATTCCCCCCCAACCCCACCTCGGGCCTCACGACGGTGCTACCTAAGAAAGTCTTCCCTCCCACCCCCCGCTAGCCTGGTCAGTGGT
CAGCAAATTGGAAGAGGATCCGATGGGAGTGTAAATGTGAGACACAATGTCTTGATTATACCTGTTTGTGGTTTAGCTTTGTATTTAAAC

>74120_74120_4_RIMKLB-SETD8_RIMKLB_chr12_8906689_ENST00000535829_SETD8_chr12_123873980_ENST00000402868_length(amino acids)=584AA_BP=233
MIKMCSSVAAKLWFLTDRRIREDYPQKEILRALKAKCCEEELDFRAVVMDEVVLTIEQGNLGLRINGELITAYPQVVVVRVPTPWVQSDS
DITVLRHLEKMGCRLMNRPQAILNCVNKFWTFQELAGHGVPLPDTFSYGGHENFAKMIDEAEVLEFPMVVKNTRGHRGKAVFLARDKHHL
ADLSHLIRHEAPYLFQKYVKESHGRDVRVIVVGGRVVGTMLRCSTDGRMQSNCSLGRKMSKPRAVEAAAAAAAVAATAPGPEMVERRGPG
RPRTDGENVFTGQSKIYSYMSPNKCSGMRFPLQEENSVTHHEVKCQGKPLAGIYRKREEKRNAGNAVRSAMKSEEQKIKDARKGPLVPFP
NQKSEAAEPPKTPPSSCDSTNAAIAKQALKKPIKGKQAPRKKAQGKTQQNRKLTDFYPVRRSSRKSKAELQSEERKRIDELIESGKEEGM
KIDLIDGKGRGVIATKQFSRGDFVVEYHGDLIEITDAKKREALYAQDPSTGCYMYYFQYLSKTYCVDATRETNRLGRLINHSKCGNCQTK

--------------------------------------------------------------
>74120_74120_5_RIMKLB-SETD8_RIMKLB_chr12_8906689_ENST00000538135_SETD8_chr12_123873980_ENST00000330479_length(transcript)=4155nt_BP=1522nt
GGGGAACAGCAAATTCAGTCACAGACAATCCTCCACTCGGTCAAGAGCCACTTTTCTCTTCCTGCCTTGCCCCCCCGCAGGGGGTAAGGA
ACTGAGCGTTTAATCTTTAGCCGGTTGGCTACCAGCTAAAATTCTACTTATCTTAGTTTCTAGTGGATAGCTTTCTTATTTTGCCCATGT
TTTCTTAGAATCCCTGTTTAATATACTTTTGTCAGTAGTAGTATCTAGGAGTAGCAGGGAGAGTGACAATAAATTAGCCCCTTCTTTTTT
CCCTTGTCATTCAGGCCCCTTTTCCTCTCCAGAGGGAAATTACCAGTAAACTCTTCTAAATCTTCCACCCCTTCTCAGTCATACTGTGAA
GAAACACACTAAAGTGGACATTATTTGACCAGTGAACACGAACCCAGCTTCAGGCATTGGTTTGTTGTGGCACATGGAGAAACATCTCTT
TTAAAATATCTCCCAATTACCCTTTTCACAATTTGTATCCACCTAGGATTTGCTGCTGGGGTAAGTCACTAGATTTATTTCTCAAAGCTC
CCCTCTCTATGAGCTGAAAGACTGACCAACCATGAACACTAGTAGGGGATGGGGAAAGGGGACAGAGCAGAGCCAGTTGTTCCACACTTT
GGGAAGCAGGAGTAGCTTTTATCATCTTCCTCTGGGGAGCAGGCATAGAGACATAAACTGAGTGAAAATGGGTGGAGGAAGAACTTCTAT
ACCCACGAACAACATGTGAAGAGAGAGAACCAAACATAAAGTAAGGAGGGTAGACGTTACATCCAAGAGGAAATAATCCAGGCAAGGAAG
CACAAGCTGATCAAGATGTGTAGTTCTGTGGCTGCCAAGTTGTGGTTTTTGACAGATCGTCGCATCAGGGAAGACTATCCTCAAAAAGAG
ATTTTACGAGCATTGAAGGCCAAATGTTGTGAGGAGGAACTGGACTTTAGGGCTGTGGTGATGGATGAGGTGGTGCTGACAATCGAGCAA
GGAAACCTGGGTCTGCGGATCAATGGAGAGCTAATCACTGCCTACCCACAAGTGGTGGTAGTCAGAGTACCAACCCCTTGGGTGCAAAGT
GATAGTGACATCACTGTTTTGCGCCATCTAGAGAAGATGGGATGTCGGTTAATGAACCGACCTCAAGCCATCCTGAACTGCGTTAATAAG
TTCTGGACATTTCAAGAGTTGGCTGGCCATGGTGTTCCTCTGCCGGATACTTTCTCTTATGGTGGCCACGAAAATTTTGCTAAAATGATT
GATGAGGCTGAAGTTCTGGAGTTCCCAATGGTAGTAAAGAATACGCGGGGTCACAGAGGTAAAGCTGTTTTCTTGGCTCGAGATAAGCAC
CATTTGGCTGATCTAAGCCATCTTATTCGCCATGAAGCGCCATACCTGTTCCAGAAGTATGTTAAAGAGTCTCATGGACGGGATGTACGT
GTCATTGTCGTGGGAGGCCGTGTGGTTGGCACCATGTTACGTTGTTCAACAGATGGGAGAATGCAAAGCAACTGCTCATTAGGCAGGAAG
ATGTCCAAGCCCCGCGCGGTGGAGGCGGCGGCGGCGGCGGCGGCGGTGGCAGCGACGGCCCCGGGCCCGGAGATGGTGGAGCGGAGGGGC
CCGGGGAGGCCCCGCACCGACGGGGAGAACGTATTTACCGGGCAGTCAAAGATCTATTCCTACATGAGCCCGAACAAATGCTCTGGAATG
CGTTTCCCCCTTCAGGAAGAGAACTCAGTTACACATCACGAAGTCAAATGCCAGGGGAAACCATTAGCCGGAATCTACAGGAAACGAGAA
GAGAAAAGAAATGCTGGGAACGCAGTACGGAGCGCCATGAAGTCCGAGGAACAGAAGATCAAAGACGCCAGGAAAGGTCCCCTGGTACCT
TTTCCAAACCAAAAATCTGAAGCAGCAGAACCTCCAAAAACTCCACCCTCATCTTGTGATTCCACCAATGCAGCCATCGCCAAGCAAGCC
CTGAAAAAGCCCATCAAGGGCAAACAGGCCCCCCGAAAAAAAGCTCAAGGAAAAACGCAACAGAATCGCAAACTTACGGATTTCTACCCT
GTCCGAAGGAGCTCCAGGAAGAGCAAAGCCGAGCTGCAGTCTGAAGAAAGGAAAAGAATAGATGAATTGATTGAAAGTGGGAAGGAAGAA
GGAATGAAGATTGACCTCATCGATGGCAAAGGCAGGGGTGTGATTGCCACCAAGCAGTTCTCCCGGGGTGACTTTGTGGTGGAATACCAC
GGGGACCTCATCGAGATCACCGACGCCAAGAAACGGGAGGCTCTGTACGCACAGGACCCTTCCACGGGCTGCTACATGTACTATTTTCAG
TATCTGAGCAAAACCTACTGCGTGGATGCAACTAGAGAGACAAATCGCCTAGGAAGACTGATCAATCACAGCAAATGTGGGAACTGCCAA
ACCAAACTGCACGACATCGACGGCGTACCTCACCTCATCCTCATCGCCTCCCGAGACATCGCGGCTGGGGAGGAGCTCCTGTATGACTAT
GGGGACCGCAGCAAGGCTTCCATTGAAGCCCACCCGTGGCTGAAGCATTAACCGGTGGGCCCCGTGCCCTCCCCGCCCCACTTTCCCTTC
TTCAAAGGACAAAGTGCCCTCAAAGGGAATTGAATTTTTTTTTTACACACTTAATCTTAGCGGATTACTTCAGATGTTTTTAAAAAGTAT
ATTAAGATGCCTTTTCACTGTAGTATTTAAATATCTGTTACAGGTTTCCAAGGTGGACTTGAACAGATGGCCTTATATTACCAAAACTTT
TATATTCTAGTTGTTTTTGTACTTTTTTTGCATACAAGCCGAACGTTTGTGCTTCCCGTGCATGCAGTCAAAGACTCAGCACAGGTTTTA
GAGGAAATAGTCAAACATGAACTAGGAAGCCAGGTGAGTCTCCTTTCTCCAGTGGAAGAGCCGGGACCTTCCCCCTGCACCCCCGACATC
CAGGGACGGGGTGTGAGGAAGACGCTGCCTCCCAATGGCCTGGACGGGATGTTTCCAAGCTCTTGTTCCCCTAACGTCTCAACAGGCGCT
CACTGAAGTGTATGAATATTTTTTAAAAAGGTTTTTGCAGTAAGCTAGTCTTCCCCTCTGCTTTCTCGAAAGCTTACTGAGCCCCGGGCC
CCAAGCACGGGCCGGGCATAGATTTCCTCTTCCACAAGCTGCCGCTTTTCTGGGCACCTTGAAGCATCAGGGCGTGAAATCAAACTAGAT
GTGGGCAGGGAGAGGGTTGCTTACCTGCCCTGCTGGGGCAGGGTTTCCTGAAACTGGGTTAATTCTTTATAGAAATGTGAACACTGAATT
TATTTTAAAAAATAATAATAAAAATTTAAAAAAATTAAAAATAAAAAAAACCACAGAAAACAACTTTACATGTATATAGGTCTTGAAGTG
AGTGAAGTGGCTGCTTTTTTTTTTTTTTTTTTTTGCTTTTTTTTGCTTTTTGTAGAAGAGATTGAGAATGGTACTCTAATCAAAAATAAA
GTTTTGTAGTGGGACCAGAAATTACTTACCTGACATCCACCCCCATTCCCCCTCATCCTGCTGGGGTTGAAAGTTCCAGACCTGCTGTCG
AGGCCTTGTGTTTGTCAGACACCCAGTGTCCTCCTGCAAGGACGCAACTGTGAGCTGAGGTGTGAGCCTAGGAGCACACAGGGCCCGGCA
GCCCCCAGGAATCAAGGATAGGGCTAAGGTTTTCACCTTAACTGTGAAGGCAGGAGGAATAGGTGACTGCTTCCTCCCGCCCTTCACAGA
ACTGATTCTCACACACTGTCCCTTCAGTCCAGGGGGCCGGGGCTCAGGAGCCATGACCTGGTGTCTCCTGCCCACCCTGGTCCCAGGTAA
ATGTGAATGGAGACAGGTATGAGAGGCTGTCCTCGTCTTTGATTCCCCCCCAACCCCACCTCGGGCCTCACGACGGTGCTACCTAAGAAA
GTCTTCCCTCCCACCCCCCGCTAGCCTGGTCAGTGGTCAGCAAATTGGAAGAGGATCCGATGGGAGTGTAAATGTGAGACACAATGTCTT
GATTATACCTGTTTGTGGTTTAGCTTTGTATTTAAACAAGGAAATAAACTTGAAAATTATTTGTCATCATAAAAATGAAACAAATTAAAA

>74120_74120_5_RIMKLB-SETD8_RIMKLB_chr12_8906689_ENST00000538135_SETD8_chr12_123873980_ENST00000330479_length(amino acids)=584AA_BP=233
MIKMCSSVAAKLWFLTDRRIREDYPQKEILRALKAKCCEEELDFRAVVMDEVVLTIEQGNLGLRINGELITAYPQVVVVRVPTPWVQSDS
DITVLRHLEKMGCRLMNRPQAILNCVNKFWTFQELAGHGVPLPDTFSYGGHENFAKMIDEAEVLEFPMVVKNTRGHRGKAVFLARDKHHL
ADLSHLIRHEAPYLFQKYVKESHGRDVRVIVVGGRVVGTMLRCSTDGRMQSNCSLGRKMSKPRAVEAAAAAAAVAATAPGPEMVERRGPG
RPRTDGENVFTGQSKIYSYMSPNKCSGMRFPLQEENSVTHHEVKCQGKPLAGIYRKREEKRNAGNAVRSAMKSEEQKIKDARKGPLVPFP
NQKSEAAEPPKTPPSSCDSTNAAIAKQALKKPIKGKQAPRKKAQGKTQQNRKLTDFYPVRRSSRKSKAELQSEERKRIDELIESGKEEGM
KIDLIDGKGRGVIATKQFSRGDFVVEYHGDLIEITDAKKREALYAQDPSTGCYMYYFQYLSKTYCVDATRETNRLGRLINHSKCGNCQTK

--------------------------------------------------------------
>74120_74120_6_RIMKLB-SETD8_RIMKLB_chr12_8906689_ENST00000538135_SETD8_chr12_123873980_ENST00000402868_length(transcript)=4226nt_BP=1522nt
GGGGAACAGCAAATTCAGTCACAGACAATCCTCCACTCGGTCAAGAGCCACTTTTCTCTTCCTGCCTTGCCCCCCCGCAGGGGGTAAGGA
ACTGAGCGTTTAATCTTTAGCCGGTTGGCTACCAGCTAAAATTCTACTTATCTTAGTTTCTAGTGGATAGCTTTCTTATTTTGCCCATGT
TTTCTTAGAATCCCTGTTTAATATACTTTTGTCAGTAGTAGTATCTAGGAGTAGCAGGGAGAGTGACAATAAATTAGCCCCTTCTTTTTT
CCCTTGTCATTCAGGCCCCTTTTCCTCTCCAGAGGGAAATTACCAGTAAACTCTTCTAAATCTTCCACCCCTTCTCAGTCATACTGTGAA
GAAACACACTAAAGTGGACATTATTTGACCAGTGAACACGAACCCAGCTTCAGGCATTGGTTTGTTGTGGCACATGGAGAAACATCTCTT
TTAAAATATCTCCCAATTACCCTTTTCACAATTTGTATCCACCTAGGATTTGCTGCTGGGGTAAGTCACTAGATTTATTTCTCAAAGCTC
CCCTCTCTATGAGCTGAAAGACTGACCAACCATGAACACTAGTAGGGGATGGGGAAAGGGGACAGAGCAGAGCCAGTTGTTCCACACTTT
GGGAAGCAGGAGTAGCTTTTATCATCTTCCTCTGGGGAGCAGGCATAGAGACATAAACTGAGTGAAAATGGGTGGAGGAAGAACTTCTAT
ACCCACGAACAACATGTGAAGAGAGAGAACCAAACATAAAGTAAGGAGGGTAGACGTTACATCCAAGAGGAAATAATCCAGGCAAGGAAG
CACAAGCTGATCAAGATGTGTAGTTCTGTGGCTGCCAAGTTGTGGTTTTTGACAGATCGTCGCATCAGGGAAGACTATCCTCAAAAAGAG
ATTTTACGAGCATTGAAGGCCAAATGTTGTGAGGAGGAACTGGACTTTAGGGCTGTGGTGATGGATGAGGTGGTGCTGACAATCGAGCAA
GGAAACCTGGGTCTGCGGATCAATGGAGAGCTAATCACTGCCTACCCACAAGTGGTGGTAGTCAGAGTACCAACCCCTTGGGTGCAAAGT
GATAGTGACATCACTGTTTTGCGCCATCTAGAGAAGATGGGATGTCGGTTAATGAACCGACCTCAAGCCATCCTGAACTGCGTTAATAAG
TTCTGGACATTTCAAGAGTTGGCTGGCCATGGTGTTCCTCTGCCGGATACTTTCTCTTATGGTGGCCACGAAAATTTTGCTAAAATGATT
GATGAGGCTGAAGTTCTGGAGTTCCCAATGGTAGTAAAGAATACGCGGGGTCACAGAGGTAAAGCTGTTTTCTTGGCTCGAGATAAGCAC
CATTTGGCTGATCTAAGCCATCTTATTCGCCATGAAGCGCCATACCTGTTCCAGAAGTATGTTAAAGAGTCTCATGGACGGGATGTACGT
GTCATTGTCGTGGGAGGCCGTGTGGTTGGCACCATGTTACGTTGTTCAACAGATGGGAGAATGCAAAGCAACTGCTCATTAGGCAGGAAG
ATGTCCAAGCCCCGCGCGGTGGAGGCGGCGGCGGCGGCGGCGGCGGTGGCAGCGACGGCCCCGGGCCCGGAGATGGTGGAGCGGAGGGGC
CCGGGGAGGCCCCGCACCGACGGGGAGAACGTATTTACCGGGCAGTCAAAGATCTATTCCTACATGAGCCCGAACAAATGCTCTGGAATG
CGTTTCCCCCTTCAGGAAGAGAACTCAGTTACACATCACGAAGTCAAATGCCAGGGGAAACCATTAGCCGGAATCTACAGGAAACGAGAA
GAGAAAAGAAATGCTGGGAACGCAGTACGGAGCGCCATGAAGTCCGAGGAACAGAAGATCAAAGACGCCAGGAAAGGTCCCCTGGTACCT
TTTCCAAACCAAAAATCTGAAGCAGCAGAACCTCCAAAAACTCCACCCTCATCTTGTGATTCCACCAATGCAGCCATCGCCAAGCAAGCC
CTGAAAAAGCCCATCAAGGGCAAACAGGCCCCCCGAAAAAAAGCTCAAGGAAAAACGCAACAGAATCGCAAACTTACGGATTTCTACCCT
GTCCGAAGGAGCTCCAGGAAGAGCAAAGCCGAGCTGCAGTCTGAAGAAAGGAAAAGAATAGATGAATTGATTGAAAGTGGGAAGGAAGAA
GGAATGAAGATTGACCTCATCGATGGCAAAGGCAGGGGTGTGATTGCCACCAAGCAGTTCTCCCGGGGTGACTTTGTGGTGGAATACCAC
GGGGACCTCATCGAGATCACCGACGCCAAGAAACGGGAGGCTCTGTACGCACAGGACCCTTCCACGGGCTGCTACATGTACTATTTTCAG
TATCTGAGCAAAACCTACTGCGTGGATGCAACTAGAGAGACAAATCGCCTAGGAAGACTGATCAATCACAGCAAATGTGGGAACTGCCAA
ACCAAACTGCACGACATCGACGGCGTACCTCACCTCATCCTCATCGCCTCCCGAGACATCGCGGCTGGGGAGGAGCTCCTGTATGACTAT
GGGGACCGCAGCAAGGCTTCCATTGAAGCCCACCCGTGGCTGAAGCATTAACCGGTGGGCCCCGTGCCCTCCCCGCCCCACTTTCCCTTC
TTCAAAGGACAAAGTGCCCTCAAAGGGAATTGAATTTTTTTTTTACACACTTAATCTTAGCGGATTACTTCAGATGTTTTTAAAAAGTAT
ATTAAGATGCCTTTTCACTGTAGTATTTAAATATCTGTTACAGGTTTCCAAGGTGGACTTGAACAGATGGCCTTATATTACCAAAACTTT
TATATTCTAGTTGTTTTTGTACTTTTTTTGCATACAAGCCGAACGTTTGTGCTTCCCGTGCATGCAGTCAAAGACTCAGCACAGGTTTTA
GAGGAAATAGTCAAACATGAACTAGGAAGCCAGGTGAGTCTCCTTTCTCCAGTGGAAGAGCCGGGACCTTCCCCCTGCACCCCCGACATC
CAGGGACGGGGTGTGAGGAAGACGCTGCCTCCCAATGGCCTGGACGGGATGTTTCCAAGCTCTTGTTCCCCTAACGTCTCAACAGGCGCT
CACTGAAGTGTATGAATATTTTTTAAAAAGGTTTTTGCAGTAAGCTAGTCTTCCCCTCTGCTTTCTCGAAAGCTTACTGAGCCCCGGGCC
CCAAGCACGGGCCGGGCATAGATTTCCTCTTCCACAAGCTGCCGCTTTTCTGGGCACCTTGAAGCATCAGGGCGTGAAATCAAACTAGAT
GTGGGCAGGGAGAGGGTTGCTTACCTGCCCTGCTGGGGCAGGGTTTCCTGAAACTGGGTTAATTCTTTATAGAAATGTGAACACTGAATT
TATTTTAAAAAATAATAATAAAAATTTAAAAAAATTAAAAATAAAAAAAACCACAGAAAACAACTTTACATGTATATAGGTCTTGAAGTG
AGTGAAGTGGCTGCTTTTTTTTTTTTTTTTTTTTGCTTTTTTTTGCTTTTTGTAGAAGAGATTGAGAATGGTACTCTAATCAAAAATAAA
GTTTTGTAGTGGGACCAGAAATTACTTACCTGACATCCACCCCCATTCCCCCTCATCCTGCTGGGGTTGAAAGTTCCAGACCTGCTGTCG
AGGCCTTGTGTTTGTCAGACACCCAGTGTCCTCCTGCAAGGACGCAACTGTGAGCTGAGGTGTGAGCCTAGGAGCCCAGGACCCCTGACC
CCGGCCGCTGCTGCCAGCCTCAGAAAGGCACCCAGGTGTGCAGGGGAGCACACAGGGCCCGGCAGCCCCCAGGAATCAAGGATAGGGCTA
AGGTTTTCACCTTAACTGTGAAGGCAGGAGGAATAGGTGACTGCTTCCTCCCGCCCTTCACAGAACTGATTCTCACACACTGTCCCTTCA
GTCCAGGGGGCCGGGGCTCAGGAGCCATGACCTGGTGTCTCCTGCCCACCCTGGTCCCAGGTAAATGTGAATGGAGACAGGTATGAGAGG
CTGTCCTCGTCTTTGATTCCCCCCCAACCCCACCTCGGGCCTCACGACGGTGCTACCTAAGAAAGTCTTCCCTCCCACCCCCCGCTAGCC
TGGTCAGTGGTCAGCAAATTGGAAGAGGATCCGATGGGAGTGTAAATGTGAGACACAATGTCTTGATTATACCTGTTTGTGGTTTAGCTT

>74120_74120_6_RIMKLB-SETD8_RIMKLB_chr12_8906689_ENST00000538135_SETD8_chr12_123873980_ENST00000402868_length(amino acids)=584AA_BP=233
MIKMCSSVAAKLWFLTDRRIREDYPQKEILRALKAKCCEEELDFRAVVMDEVVLTIEQGNLGLRINGELITAYPQVVVVRVPTPWVQSDS
DITVLRHLEKMGCRLMNRPQAILNCVNKFWTFQELAGHGVPLPDTFSYGGHENFAKMIDEAEVLEFPMVVKNTRGHRGKAVFLARDKHHL
ADLSHLIRHEAPYLFQKYVKESHGRDVRVIVVGGRVVGTMLRCSTDGRMQSNCSLGRKMSKPRAVEAAAAAAAVAATAPGPEMVERRGPG
RPRTDGENVFTGQSKIYSYMSPNKCSGMRFPLQEENSVTHHEVKCQGKPLAGIYRKREEKRNAGNAVRSAMKSEEQKIKDARKGPLVPFP
NQKSEAAEPPKTPPSSCDSTNAAIAKQALKKPIKGKQAPRKKAQGKTQQNRKLTDFYPVRRSSRKSKAELQSEERKRIDELIESGKEEGM
KIDLIDGKGRGVIATKQFSRGDFVVEYHGDLIEITDAKKREALYAQDPSTGCYMYYFQYLSKTYCVDATRETNRLGRLINHSKCGNCQTK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RIMKLB-SETD8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RIMKLB-SETD8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RIMKLB-SETD8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource