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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATF2-TECR (FusionGDB2 ID:7415)

Fusion Gene Summary for ATF2-TECR

check button Fusion gene summary
Fusion gene informationFusion gene name: ATF2-TECR
Fusion gene ID: 7415
HgeneTgene
Gene symbol

ATF2

TECR

Gene ID

2668

9524

Gene nameglial cell derived neurotrophic factortrans-2,3-enoyl-CoA reductase
SynonymsATF|ATF1|ATF2|HFB1-GDNF|HSCR3GPSN2|MRT14|SC2|TER
Cytomap

5p13.2

19p13.12

Type of geneprotein-codingprotein-coding
Descriptionglial cell line-derived neurotrophic factorastrocyte-derived trophic factorvery-long-chain enoyl-CoA reductaseepididymis secretory sperm binding proteinglycoprotein, synaptic 2synaptic glycoprotein SC2
Modification date2020031420200320
UniProtAcc

P15336

.
Ensembl transtripts involved in fusion geneENST00000264110, ENST00000345739, 
ENST00000392543, ENST00000392544, 
ENST00000409499, ENST00000409635, 
ENST00000409833, ENST00000413123, 
ENST00000426833, ENST00000487334, 
ENST00000538946, ENST00000409437, 
ENST00000215567, ENST00000596164, 
ENST00000436007, ENST00000596073, 
ENST00000600083, 
Fusion gene scores* DoF score12 X 11 X 9=11889 X 3 X 7=189
# samples 1313
** MAII scorelog2(13/1188*10)=-3.19195130777231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/189*10)=-0.539874611192618
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATF2 [Title/Abstract] AND TECR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATF2(176032778)-TECR(14673337), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATF2

GO:0001755

neural crest cell migration

15242795

HgeneATF2

GO:0008284

positive regulation of cell proliferation

22897442

HgeneATF2

GO:0031175

neuron projection development

15242795

HgeneATF2

GO:0032770

positive regulation of monooxygenase activity

12358785

HgeneATF2

GO:0043524

negative regulation of neuron apoptotic process

8493557

HgeneATF2

GO:0045944

positive regulation of transcription by RNA polymerase II

12358785

HgeneATF2

GO:0048255

mRNA stabilization

12358785

HgeneATF2

GO:0051584

regulation of dopamine uptake involved in synaptic transmission

8493557

HgeneATF2

GO:0072107

positive regulation of ureteric bud formation

8657307

HgeneATF2

GO:0090190

positive regulation of branching involved in ureteric bud morphogenesis

8657307|17229286

HgeneATF2

GO:2001240

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

10921886

TgeneTECR

GO:0030497

fatty acid elongation

12482854

TgeneTECR

GO:0042761

very long-chain fatty acid biosynthetic process

12482854


check buttonFusion gene breakpoints across ATF2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TECR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-HT-8111-01AATF2chr2

176032778

-TECRchr19

14673337

+


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Fusion Gene ORF analysis for ATF2-TECR

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000264110ENST00000215567ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-3CDSENST00000345739ENST00000215567ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-3CDSENST00000392543ENST00000215567ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-3CDSENST00000392544ENST00000215567ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-3CDSENST00000409499ENST00000215567ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-3CDSENST00000409635ENST00000215567ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-3CDSENST00000409833ENST00000215567ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-3CDSENST00000413123ENST00000215567ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-3CDSENST00000426833ENST00000215567ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-3CDSENST00000487334ENST00000215567ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-3CDSENST00000538946ENST00000215567ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-3UTRENST00000264110ENST00000596164ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-3UTRENST00000345739ENST00000596164ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-3UTRENST00000392543ENST00000596164ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-3UTRENST00000392544ENST00000596164ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-3UTRENST00000409499ENST00000596164ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-3UTRENST00000409635ENST00000596164ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-3UTRENST00000409833ENST00000596164ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-3UTRENST00000413123ENST00000596164ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-3UTRENST00000426833ENST00000596164ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-3UTRENST00000487334ENST00000596164ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-3UTRENST00000538946ENST00000596164ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-5UTRENST00000264110ENST00000436007ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-5UTRENST00000264110ENST00000596073ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-5UTRENST00000264110ENST00000600083ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-5UTRENST00000345739ENST00000436007ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-5UTRENST00000345739ENST00000596073ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-5UTRENST00000345739ENST00000600083ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-5UTRENST00000392543ENST00000436007ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-5UTRENST00000392543ENST00000596073ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-5UTRENST00000392543ENST00000600083ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-5UTRENST00000392544ENST00000436007ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-5UTRENST00000392544ENST00000596073ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-5UTRENST00000392544ENST00000600083ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-5UTRENST00000409499ENST00000436007ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-5UTRENST00000409499ENST00000596073ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-5UTRENST00000409499ENST00000600083ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-5UTRENST00000409635ENST00000436007ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-5UTRENST00000409635ENST00000596073ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-5UTRENST00000409635ENST00000600083ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-5UTRENST00000409833ENST00000436007ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-5UTRENST00000409833ENST00000596073ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-5UTRENST00000409833ENST00000600083ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-5UTRENST00000413123ENST00000436007ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-5UTRENST00000413123ENST00000596073ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-5UTRENST00000413123ENST00000600083ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-5UTRENST00000426833ENST00000436007ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-5UTRENST00000426833ENST00000596073ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-5UTRENST00000426833ENST00000600083ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-5UTRENST00000487334ENST00000436007ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-5UTRENST00000487334ENST00000596073ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-5UTRENST00000487334ENST00000600083ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-5UTRENST00000538946ENST00000436007ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-5UTRENST00000538946ENST00000596073ATF2chr2

176032778

-TECRchr19

14673337

+
5UTR-5UTRENST00000538946ENST00000600083ATF2chr2

176032778

-TECRchr19

14673337

+
intron-3CDSENST00000409437ENST00000215567ATF2chr2

176032778

-TECRchr19

14673337

+
intron-3UTRENST00000409437ENST00000596164ATF2chr2

176032778

-TECRchr19

14673337

+
intron-5UTRENST00000409437ENST00000436007ATF2chr2

176032778

-TECRchr19

14673337

+
intron-5UTRENST00000409437ENST00000596073ATF2chr2

176032778

-TECRchr19

14673337

+
intron-5UTRENST00000409437ENST00000600083ATF2chr2

176032778

-TECRchr19

14673337

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ATF2-TECR


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ATF2chr2176032777-TECRchr1914673336+4.35E-060.9999957
ATF2chr2176032777-TECRchr1914673336+4.35E-060.9999957

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ATF2-TECR


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:176032778/:14673337)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATF2

P15336

.
FUNCTION: Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro (PubMed:10821277). In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type. {ECO:0000269|PubMed:10821277, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:18397884, ECO:0000269|PubMed:22304920}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ATF2-TECR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ATF2-TECR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATF2-TECR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATF2-TECR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource