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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATF6B-GLI4 (FusionGDB2 ID:7441)

Fusion Gene Summary for ATF6B-GLI4

check button Fusion gene summary
Fusion gene informationFusion gene name: ATF6B-GLI4
Fusion gene ID: 7441
HgeneTgene
Gene symbol

ATF6B

GLI4

Gene ID

1388

2738

Gene nameactivating transcription factor 6 betaGLI family zinc finger 4
SynonymsCREB-RP|CREBL1|G13HKR4|ZNF928
Cytomap

6p21.32

8q24.3

Type of geneprotein-codingprotein-coding
Descriptioncyclic AMP-dependent transcription factor ATF-6 betaCreb-related proteincAMP response element-binding protein-related proteincAMP-dependent transcription factor ATF-6 betacAMP-responsive element-binding protein-like 1protein G13zinc finger protein GLI4GLI-Kruppel family member GLI4 (oncogene HKR4)glioma-associated oncogene family zinc finger 4krueppel-related zinc finger protein 4
Modification date2020031320200313
UniProtAcc

Q99941

P10075

Ensembl transtripts involved in fusion geneENST00000375201, ENST00000375203, 
ENST00000293709, ENST00000383156, 
ENST00000425571, ENST00000427136, 
ENST00000435768, ENST00000439240, 
ENST00000467437, ENST00000468502, 
ENST00000475964, ENST00000476416, 
ENST00000547111, ENST00000549095, 
ENST00000553220, 		ENST00000523812, 
ENST00000517468, ENST00000523522, 
ENST00000340042, ENST00000521682, 
ENST00000344692, 
Fusion gene scores* DoF score4 X 4 X 3=482 X 2 X 2=8
# samples 42
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: ATF6B [Title/Abstract] AND GLI4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATF6B(32085635)-GLI4(144356873), # samples:1
Anticipated loss of major functional domain due to fusion event.ATF6B-GLI4 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
ATF6B-GLI4 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
ATF6B-GLI4 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATF6B

GO:0045944

positive regulation of transcription by RNA polymerase II

14973138

HgeneATF6B

GO:1903892

negative regulation of ATF6-mediated unfolded protein response

9837962

HgeneATF6B

GO:1990440

positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

11256944


check buttonFusion gene breakpoints across ATF6B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GLI4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-IN-AB1V-11AATF6Bchr6

32085635

-GLI4chr8

144356873

+


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Fusion Gene ORF analysis for ATF6B-GLI4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000375201ENST00000523812ATF6Bchr6

32085635

-GLI4chr8

144356873

+
5CDS-3UTRENST00000375203ENST00000523812ATF6Bchr6

32085635

-GLI4chr8

144356873

+
5CDS-intronENST00000375201ENST00000517468ATF6Bchr6

32085635

-GLI4chr8

144356873

+
5CDS-intronENST00000375201ENST00000523522ATF6Bchr6

32085635

-GLI4chr8

144356873

+
5CDS-intronENST00000375203ENST00000517468ATF6Bchr6

32085635

-GLI4chr8

144356873

+
5CDS-intronENST00000375203ENST00000523522ATF6Bchr6

32085635

-GLI4chr8

144356873

+
Frame-shiftENST00000375201ENST00000340042ATF6Bchr6

32085635

-GLI4chr8

144356873

+
Frame-shiftENST00000375201ENST00000521682ATF6Bchr6

32085635

-GLI4chr8

144356873

+
Frame-shiftENST00000375203ENST00000340042ATF6Bchr6

32085635

-GLI4chr8

144356873

+
Frame-shiftENST00000375203ENST00000521682ATF6Bchr6

32085635

-GLI4chr8

144356873

+
In-frameENST00000375201ENST00000344692ATF6Bchr6

32085635

-GLI4chr8

144356873

+
In-frameENST00000375203ENST00000344692ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-3CDSENST00000293709ENST00000340042ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-3CDSENST00000293709ENST00000344692ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-3CDSENST00000293709ENST00000521682ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-3CDSENST00000383156ENST00000340042ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-3CDSENST00000383156ENST00000344692ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-3CDSENST00000383156ENST00000521682ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-3CDSENST00000425571ENST00000340042ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-3CDSENST00000425571ENST00000344692ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-3CDSENST00000425571ENST00000521682ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-3CDSENST00000427136ENST00000340042ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-3CDSENST00000427136ENST00000344692ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-3CDSENST00000427136ENST00000521682ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-3CDSENST00000435768ENST00000340042ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-3CDSENST00000435768ENST00000344692ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-3CDSENST00000435768ENST00000521682ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-3CDSENST00000439240ENST00000340042ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-3CDSENST00000439240ENST00000344692ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-3CDSENST00000439240ENST00000521682ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-3CDSENST00000467437ENST00000340042ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-3CDSENST00000467437ENST00000344692ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-3CDSENST00000467437ENST00000521682ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-3CDSENST00000468502ENST00000340042ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-3CDSENST00000468502ENST00000344692ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-3CDSENST00000468502ENST00000521682ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-3CDSENST00000475964ENST00000340042ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-3CDSENST00000475964ENST00000344692ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-3CDSENST00000475964ENST00000521682ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-3CDSENST00000476416ENST00000340042ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-3CDSENST00000476416ENST00000344692ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-3CDSENST00000476416ENST00000521682ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-3CDSENST00000547111ENST00000340042ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-3CDSENST00000547111ENST00000344692ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-3CDSENST00000547111ENST00000521682ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-3CDSENST00000549095ENST00000340042ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-3CDSENST00000549095ENST00000344692ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-3CDSENST00000549095ENST00000521682ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-3CDSENST00000553220ENST00000340042ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-3CDSENST00000553220ENST00000344692ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-3CDSENST00000553220ENST00000521682ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-3UTRENST00000293709ENST00000523812ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-3UTRENST00000383156ENST00000523812ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-3UTRENST00000425571ENST00000523812ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-3UTRENST00000427136ENST00000523812ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-3UTRENST00000435768ENST00000523812ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-3UTRENST00000439240ENST00000523812ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-3UTRENST00000467437ENST00000523812ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-3UTRENST00000468502ENST00000523812ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-3UTRENST00000475964ENST00000523812ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-3UTRENST00000476416ENST00000523812ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-3UTRENST00000547111ENST00000523812ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-3UTRENST00000549095ENST00000523812ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-3UTRENST00000553220ENST00000523812ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-intronENST00000293709ENST00000517468ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-intronENST00000293709ENST00000523522ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-intronENST00000383156ENST00000517468ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-intronENST00000383156ENST00000523522ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-intronENST00000425571ENST00000517468ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-intronENST00000425571ENST00000523522ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-intronENST00000427136ENST00000517468ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-intronENST00000427136ENST00000523522ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-intronENST00000435768ENST00000517468ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-intronENST00000435768ENST00000523522ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-intronENST00000439240ENST00000517468ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-intronENST00000439240ENST00000523522ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-intronENST00000467437ENST00000517468ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-intronENST00000467437ENST00000523522ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-intronENST00000468502ENST00000517468ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-intronENST00000468502ENST00000523522ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-intronENST00000475964ENST00000517468ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-intronENST00000475964ENST00000523522ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-intronENST00000476416ENST00000517468ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-intronENST00000476416ENST00000523522ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-intronENST00000547111ENST00000517468ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-intronENST00000547111ENST00000523522ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-intronENST00000549095ENST00000517468ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-intronENST00000549095ENST00000523522ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-intronENST00000553220ENST00000517468ATF6Bchr6

32085635

-GLI4chr8

144356873

+
intron-intronENST00000553220ENST00000523522ATF6Bchr6

32085635

-GLI4chr8

144356873

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000375203ATF6Bchr632085635-ENST00000344692GLI4chr8144356873+2306145791478489
ENST00000375201ATF6Bchr632085635-ENST00000344692GLI4chr8144356873+23101461221482486

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000375203ENST00000344692ATF6Bchr632085635-GLI4chr8144356873+0.03393590.9660641
ENST00000375201ENST00000344692ATF6Bchr632085635-GLI4chr8144356873+0.0325561950.9674439

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Fusion Genomic Features for ATF6B-GLI4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ATF6Bchr632085635-GLI4chr8144356873+0.0001003820.9998996
ATF6Bchr632085635-GLI4chr8144356873+0.0001003820.9998996

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ATF6B-GLI4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:32085635/chr8:144356873)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATF6B

Q99941

GLI4

P10075

FUNCTION: [Cyclic AMP-dependent transcription factor ATF-6 beta]: Precursor of the transcription factor form (Processed cyclic AMP-dependent transcription factor ATF-6 beta), which is embedded in the endoplasmic reticulum membrane (PubMed:11256944). Endoplasmic reticulum stress promotes processing of this form, releasing the transcription factor form that translocates into the nucleus, where it activates transcription of genes involved in the unfolded protein response (UPR) (PubMed:11256944). {ECO:0000269|PubMed:11256944}.; FUNCTION: [Processed cyclic AMP-dependent transcription factor ATF-6 beta]: Transcription factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress (PubMed:11256944). Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCAC[GA]-3') when NF-Y is bound to ERSE (PubMed:11256944). {ECO:0000269|PubMed:11256944}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATF6Bchr6:32085635chr8:144356873ENST00000375201-121896_105471701.0Compositional biasNote=Poly-Ser
HgeneATF6Bchr6:32085635chr8:144356873ENST00000375203-121896_105474704.0Compositional biasNote=Poly-Ser
HgeneATF6Bchr6:32085635chr8:144356873ENST00000375201-1218325_388471701.0DomainbZIP
HgeneATF6Bchr6:32085635chr8:144356873ENST00000375203-1218325_388474704.0DomainbZIP
HgeneATF6Bchr6:32085635chr8:144356873ENST00000375201-12182_86471701.0RegionNote=Transcription activation
HgeneATF6Bchr6:32085635chr8:144356873ENST00000375201-1218327_347471701.0RegionBasic motif
HgeneATF6Bchr6:32085635chr8:144356873ENST00000375201-1218350_357471701.0RegionLeucine-zipper
HgeneATF6Bchr6:32085635chr8:144356873ENST00000375203-12182_86474704.0RegionNote=Transcription activation
HgeneATF6Bchr6:32085635chr8:144356873ENST00000375203-1218327_347474704.0RegionBasic motif
HgeneATF6Bchr6:32085635chr8:144356873ENST00000375203-1218350_357474704.0RegionLeucine-zipper
HgeneATF6Bchr6:32085635chr8:144356873ENST00000375201-12182_396471701.0Topological domainCytoplasmic
HgeneATF6Bchr6:32085635chr8:144356873ENST00000375203-12182_396474704.0Topological domainCytoplasmic
HgeneATF6Bchr6:32085635chr8:144356873ENST00000375201-1218397_417471701.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneATF6Bchr6:32085635chr8:144356873ENST00000375203-1218397_417474704.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneGLI4chr6:32085635chr8:144356873ENST0000034004214183_20541377.0Zinc fingerC2H2-type 1
TgeneGLI4chr6:32085635chr8:144356873ENST0000034004214211_23341377.0Zinc fingerC2H2-type 2
TgeneGLI4chr6:32085635chr8:144356873ENST0000034004214239_26141377.0Zinc fingerC2H2-type 3
TgeneGLI4chr6:32085635chr8:144356873ENST0000034004214267_28941377.0Zinc fingerC2H2-type 4
TgeneGLI4chr6:32085635chr8:144356873ENST0000034004214295_31741377.0Zinc fingerC2H2-type 5
TgeneGLI4chr6:32085635chr8:144356873ENST0000034004214323_34541377.0Zinc fingerC2H2-type 6
TgeneGLI4chr6:32085635chr8:144356873ENST0000034004214351_37341377.0Zinc fingerC2H2-type 7
TgeneGLI4chr6:32085635chr8:144356873ENST0000052352203183_20541377.0Zinc fingerC2H2-type 1
TgeneGLI4chr6:32085635chr8:144356873ENST0000052352203211_23341377.0Zinc fingerC2H2-type 2
TgeneGLI4chr6:32085635chr8:144356873ENST0000052352203239_26141377.0Zinc fingerC2H2-type 3
TgeneGLI4chr6:32085635chr8:144356873ENST0000052352203267_28941377.0Zinc fingerC2H2-type 4
TgeneGLI4chr6:32085635chr8:144356873ENST0000052352203295_31741377.0Zinc fingerC2H2-type 5
TgeneGLI4chr6:32085635chr8:144356873ENST0000052352203323_34541377.0Zinc fingerC2H2-type 6
TgeneGLI4chr6:32085635chr8:144356873ENST0000052352203351_37341377.0Zinc fingerC2H2-type 7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATF6Bchr6:32085635chr8:144356873ENST00000293709-11896_1050704.0Compositional biasNote=Poly-Ser
HgeneATF6Bchr6:32085635chr8:144356873ENST00000383156-11896_1050701.0Compositional biasNote=Poly-Ser
HgeneATF6Bchr6:32085635chr8:144356873ENST00000425571-11896_1050704.0Compositional biasNote=Poly-Ser
HgeneATF6Bchr6:32085635chr8:144356873ENST00000427136-11896_1050704.0Compositional biasNote=Poly-Ser
HgeneATF6Bchr6:32085635chr8:144356873ENST00000435768-11896_1050701.0Compositional biasNote=Poly-Ser
HgeneATF6Bchr6:32085635chr8:144356873ENST00000439240-11896_1050701.0Compositional biasNote=Poly-Ser
HgeneATF6Bchr6:32085635chr8:144356873ENST00000293709-118325_3880704.0DomainbZIP
HgeneATF6Bchr6:32085635chr8:144356873ENST00000383156-118325_3880701.0DomainbZIP
HgeneATF6Bchr6:32085635chr8:144356873ENST00000425571-118325_3880704.0DomainbZIP
HgeneATF6Bchr6:32085635chr8:144356873ENST00000427136-118325_3880704.0DomainbZIP
HgeneATF6Bchr6:32085635chr8:144356873ENST00000435768-118325_3880701.0DomainbZIP
HgeneATF6Bchr6:32085635chr8:144356873ENST00000439240-118325_3880701.0DomainbZIP
HgeneATF6Bchr6:32085635chr8:144356873ENST00000293709-1182_860704.0RegionNote=Transcription activation
HgeneATF6Bchr6:32085635chr8:144356873ENST00000293709-118327_3470704.0RegionBasic motif
HgeneATF6Bchr6:32085635chr8:144356873ENST00000293709-118350_3570704.0RegionLeucine-zipper
HgeneATF6Bchr6:32085635chr8:144356873ENST00000383156-1182_860701.0RegionNote=Transcription activation
HgeneATF6Bchr6:32085635chr8:144356873ENST00000383156-118327_3470701.0RegionBasic motif
HgeneATF6Bchr6:32085635chr8:144356873ENST00000383156-118350_3570701.0RegionLeucine-zipper
HgeneATF6Bchr6:32085635chr8:144356873ENST00000425571-1182_860704.0RegionNote=Transcription activation
HgeneATF6Bchr6:32085635chr8:144356873ENST00000425571-118327_3470704.0RegionBasic motif
HgeneATF6Bchr6:32085635chr8:144356873ENST00000425571-118350_3570704.0RegionLeucine-zipper
HgeneATF6Bchr6:32085635chr8:144356873ENST00000427136-1182_860704.0RegionNote=Transcription activation
HgeneATF6Bchr6:32085635chr8:144356873ENST00000427136-118327_3470704.0RegionBasic motif
HgeneATF6Bchr6:32085635chr8:144356873ENST00000427136-118350_3570704.0RegionLeucine-zipper
HgeneATF6Bchr6:32085635chr8:144356873ENST00000435768-1182_860701.0RegionNote=Transcription activation
HgeneATF6Bchr6:32085635chr8:144356873ENST00000435768-118327_3470701.0RegionBasic motif
HgeneATF6Bchr6:32085635chr8:144356873ENST00000435768-118350_3570701.0RegionLeucine-zipper
HgeneATF6Bchr6:32085635chr8:144356873ENST00000439240-1182_860701.0RegionNote=Transcription activation
HgeneATF6Bchr6:32085635chr8:144356873ENST00000439240-118327_3470701.0RegionBasic motif
HgeneATF6Bchr6:32085635chr8:144356873ENST00000439240-118350_3570701.0RegionLeucine-zipper
HgeneATF6Bchr6:32085635chr8:144356873ENST00000293709-1182_3960704.0Topological domainCytoplasmic
HgeneATF6Bchr6:32085635chr8:144356873ENST00000293709-118418_7030704.0Topological domainLumenal
HgeneATF6Bchr6:32085635chr8:144356873ENST00000375201-1218418_703471701.0Topological domainLumenal
HgeneATF6Bchr6:32085635chr8:144356873ENST00000375203-1218418_703474704.0Topological domainLumenal
HgeneATF6Bchr6:32085635chr8:144356873ENST00000383156-1182_3960701.0Topological domainCytoplasmic
HgeneATF6Bchr6:32085635chr8:144356873ENST00000383156-118418_7030701.0Topological domainLumenal
HgeneATF6Bchr6:32085635chr8:144356873ENST00000425571-1182_3960704.0Topological domainCytoplasmic
HgeneATF6Bchr6:32085635chr8:144356873ENST00000425571-118418_7030704.0Topological domainLumenal
HgeneATF6Bchr6:32085635chr8:144356873ENST00000427136-1182_3960704.0Topological domainCytoplasmic
HgeneATF6Bchr6:32085635chr8:144356873ENST00000427136-118418_7030704.0Topological domainLumenal
HgeneATF6Bchr6:32085635chr8:144356873ENST00000435768-1182_3960701.0Topological domainCytoplasmic
HgeneATF6Bchr6:32085635chr8:144356873ENST00000435768-118418_7030701.0Topological domainLumenal
HgeneATF6Bchr6:32085635chr8:144356873ENST00000439240-1182_3960701.0Topological domainCytoplasmic
HgeneATF6Bchr6:32085635chr8:144356873ENST00000439240-118418_7030701.0Topological domainLumenal
HgeneATF6Bchr6:32085635chr8:144356873ENST00000293709-118397_4170704.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneATF6Bchr6:32085635chr8:144356873ENST00000383156-118397_4170701.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneATF6Bchr6:32085635chr8:144356873ENST00000425571-118397_4170704.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneATF6Bchr6:32085635chr8:144356873ENST00000427136-118397_4170704.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneATF6Bchr6:32085635chr8:144356873ENST00000435768-118397_4170701.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneATF6Bchr6:32085635chr8:144356873ENST00000439240-118397_4170701.0TransmembraneHelical%3B Signal-anchor for type II membrane protein


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Fusion Gene Sequence for ATF6B-GLI4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>7441_7441_1_ATF6B-GLI4_ATF6B_chr6_32085635_ENST00000375201_GLI4_chr8_144356873_ENST00000344692_length(transcript)=2310nt_BP=1461nt
GGCGGGCCTTGGGAACCGTCTCCTGGTTGGGGGGTGGGGGGGAAAGATGGCGGAGCTGATGCTGCTCAGCGAGATTGCTGACCCGACGCG
TTTCTTCACCGACAACCTGCTTAGCCCGGAGGACTGGGACAGCACCTTGTATTCTGGCCTAGATGAAGTGGCCGAGGAGCAGACGCAGCT
CTTCCGTTGCCCGGAGCAGGATGTCCCGTTTGACGGCAGCTCCCTGGACGTGGGGATGGATGTCAGCCCCTCTGAGCCCCCATGGGAACT
CCTGCCGATCTTCCCAGATCTTCAGGTGAAGTCTGAGCCATCTTCCCCCTGCTCTTCCTCCTCCCTCAGCTCCGAGTCATCGCGTCTCTC
CACAGAGCCATCCAGCGAGGCTCTTGGGGTAGGGGAGGTGCTCCATGTGAAGACAGAGTCCTTGGCACCCCCACTGTGTCTCCTGGGAGA
TGACCCAACATCCTCATTTGAAACCGTCCAGATCAACGTTATCCCCACCTCTGATGATTCCTCAGATGTCCAGACCAAGATAGAACCTGT
CTCTCCATGTTCTTCCGTCAACTCTGAGGCCTCCCTGCTCTCAGCCGACTCCTCCAGCCAGGCTTTTATAGGAGAGGAGGTCCTGGAAGT
GAAGACAGAGTCCCTGTCCCCTTCAGGATGCCTCCTGTGGGATGTCCCAGCCCCCTCACTTGGAGCTGTCCAGATCAGCATGGGCCCATC
CCTTGATGGCTCCTCAGGCAAAGCCCTGCCCACCCGGAAGCCGCCACTGCAGCCCAAACCTGTAGTGCTAACCACTGTCCCAATGCCATC
CAGAGCTGTGCCTCCCAGCACCACAGTCCTTCTGCAGTCCCTCGTCCAGCCACCCCCAGTGTCCCCAGTTGTCCTCATCCAGGGTGCTAT
TCGAGTCCAGCCTGAAGGGCCGGCTCCCTCTCTACCACGGCCTGAGAGGAAGAGCATCGTTCCCGCTCCTATGCCTGGAAACTCCTGCCC
GCCTGAAGTGGATGCAAAGCTGCTGAAGCGGCAGCAGCGAATGATCAAGAACCGGGAGTCAGCCTGCCAGTCCCGGAGAAAGAAGAAAGA
GTATCTGCAGGGACTGGAGGCTCGGCTGCAAGCAGTACTGGCTGACAACCAGCAGCTCCGCCGAGAGAATGCTGCCCTCCGGCGGCGGCT
GGAGGCCCTGCTGGCTGAAAACAGCGAGCTCAAGTTAGGGTCTGGAAACAGGAAGGTGGTCTGCATCATGGTCTTCCTTCTCTTCATTGC
CTTCAACTTTGGACCTGTCAGCATCAGTGAGCCTCCTTCAGCTCCCATCTCTCCTCGGATGAACAAGGGGGAGCCTCAACCCCGGAGACA
CTTGCTGGGGTTCTCAGAGCAAGAGCCAGTTCAGGGAGTTGAACCTCTCCAGGGGTCCTCCCAGGGCCCTAAGGAGCCCCAGCCCAGCCC
CACAGACCAGCCCAGTTTCAGGCTCCCCTGGCTCCAGCCCTAAGGTGCTCTCCCAGCCGTCCGACCTGGATCTCCAAGACGTAGAGGAAG
TGGAGATCGGCAGAGACACCTTCTGGCCCGGTGAGTGAGCAGAATCGGGTTACTGGGGGACCAGAGCTCTGCGCGTGCCAGGCTCCTCAC
AATGCCCACCTCTGTGGCACCCCCAATGCTGGCACCACCCCCTTCCTGGGGCCCCTTTTCTTCCCTGGCATCAGCTCACCTCTGCCCCGT
GGCCCCTCCCCCACTCTAATGCCAGTCCAGTTACTGATGCTTCCCGAGGCGGTGACTGCAGCCCACAGCCACCTGCGCCAGTGGCCCCAC
GTGGACTCCTGCCGGCCCCAGCTGGACACAGTGAATCAGGAACTCCTCCCTCCCCTCCACCTGCCTTGGGCTGGGGCTTCTGGCTCAGGG
CACCACTGTCCCCCCAGATCCACGAGTTATCCTGTGTCCCCTCCTCCTCCTGCATCCCCTAGATGGCCTCCCCTCAGCCTGGTTGGAGCT
GTGTCCAGGTCCCCTGCACCTCCCCCTTGAGAAGCTCCCAGGGTTCCCTCTGGGCGATGTTAGTGATATGGCTGGATTTAACAGTGCTGA
GCCCTCGCCCACATCTGGGCGGCCCTGGGGTGGGGAGCAGGTGTCTGAGGTCAGGTCCCTGGAAAGAGACCCTGGGCCAGAGATTTGCGT
GGGAAGCTCCTGGGGTGGGCATGGGAGCTGGGCGGCAGCACACTTGCCACCGAGGCCTGGGGCAGCCCCATGAGGAGCTGTGCCCATATG

>7441_7441_1_ATF6B-GLI4_ATF6B_chr6_32085635_ENST00000375201_GLI4_chr8_144356873_ENST00000344692_length(amino acids)=486AA_BP=
MVGGWGGKMAELMLLSEIADPTRFFTDNLLSPEDWDSTLYSGLDEVAEEQTQLFRCPEQDVPFDGSSLDVGMDVSPSEPPWELLPIFPDL
QVKSEPSSPCSSSSLSSESSRLSTEPSSEALGVGEVLHVKTESLAPPLCLLGDDPTSSFETVQINVIPTSDDSSDVQTKIEPVSPCSSVN
SEASLLSADSSSQAFIGEEVLEVKTESLSPSGCLLWDVPAPSLGAVQISMGPSLDGSSGKALPTRKPPLQPKPVVLTTVPMPSRAVPPST
TVLLQSLVQPPPVSPVVLIQGAIRVQPEGPAPSLPRPERKSIVPAPMPGNSCPPEVDAKLLKRQQRMIKNRESACQSRRKKKEYLQGLEA
RLQAVLADNQQLRRENAALRRRLEALLAENSELKLGSGNRKVVCIMVFLLFIAFNFGPVSISEPPSAPISPRMNKGEPQPRRHLLGFSEQ

--------------------------------------------------------------
>7441_7441_2_ATF6B-GLI4_ATF6B_chr6_32085635_ENST00000375203_GLI4_chr8_144356873_ENST00000344692_length(transcript)=2306nt_BP=1457nt
AACCGTCTCCTGGTTGGGGGGTGGGGGGGAAAGATGGCGGAGCTGATGCTGCTCAGCGAGATTGCTGACCCGACGCGTTTCTTCACCGAC
AACCTGCTTAGCCCGGAGGACTGGGGTCTGCAGAACAGCACCTTGTATTCTGGCCTAGATGAAGTGGCCGAGGAGCAGACGCAGCTCTTC
CGTTGCCCGGAGCAGGATGTCCCGTTTGACGGCAGCTCCCTGGACGTGGGGATGGATGTCAGCCCCTCTGAGCCCCCATGGGAACTCCTG
CCGATCTTCCCAGATCTTCAGGTGAAGTCTGAGCCATCTTCCCCCTGCTCTTCCTCCTCCCTCAGCTCCGAGTCATCGCGTCTCTCCACA
GAGCCATCCAGCGAGGCTCTTGGGGTAGGGGAGGTGCTCCATGTGAAGACAGAGTCCTTGGCACCCCCACTGTGTCTCCTGGGAGATGAC
CCAACATCCTCATTTGAAACCGTCCAGATCAACGTTATCCCCACCTCTGATGATTCCTCAGATGTCCAGACCAAGATAGAACCTGTCTCT
CCATGTTCTTCCGTCAACTCTGAGGCCTCCCTGCTCTCAGCCGACTCCTCCAGCCAGGCTTTTATAGGAGAGGAGGTCCTGGAAGTGAAG
ACAGAGTCCCTGTCCCCTTCAGGATGCCTCCTGTGGGATGTCCCAGCCCCCTCACTTGGAGCTGTCCAGATCAGCATGGGCCCATCCCTT
GATGGCTCCTCAGGCAAAGCCCTGCCCACCCGGAAGCCGCCACTGCAGCCCAAACCTGTAGTGCTAACCACTGTCCCAATGCCATCCAGA
GCTGTGCCTCCCAGCACCACAGTCCTTCTGCAGTCCCTCGTCCAGCCACCCCCAGTGTCCCCAGTTGTCCTCATCCAGGGTGCTATTCGA
GTCCAGCCTGAAGGGCCGGCTCCCTCTCTACCACGGCCTGAGAGGAAGAGCATCGTTCCCGCTCCTATGCCTGGAAACTCCTGCCCGCCT
GAAGTGGATGCAAAGCTGCTGAAGCGGCAGCAGCGAATGATCAAGAACCGGGAGTCAGCCTGCCAGTCCCGGAGAAAGAAGAAAGAGTAT
CTGCAGGGACTGGAGGCTCGGCTGCAAGCAGTACTGGCTGACAACCAGCAGCTCCGCCGAGAGAATGCTGCCCTCCGGCGGCGGCTGGAG
GCCCTGCTGGCTGAAAACAGCGAGCTCAAGTTAGGGTCTGGAAACAGGAAGGTGGTCTGCATCATGGTCTTCCTTCTCTTCATTGCCTTC
AACTTTGGACCTGTCAGCATCAGTGAGCCTCCTTCAGCTCCCATCTCTCCTCGGATGAACAAGGGGGAGCCTCAACCCCGGAGACACTTG
CTGGGGTTCTCAGAGCAAGAGCCAGTTCAGGGAGTTGAACCTCTCCAGGGGTCCTCCCAGGGCCCTAAGGAGCCCCAGCCCAGCCCCACA
GACCAGCCCAGTTTCAGGCTCCCCTGGCTCCAGCCCTAAGGTGCTCTCCCAGCCGTCCGACCTGGATCTCCAAGACGTAGAGGAAGTGGA
GATCGGCAGAGACACCTTCTGGCCCGGTGAGTGAGCAGAATCGGGTTACTGGGGGACCAGAGCTCTGCGCGTGCCAGGCTCCTCACAATG
CCCACCTCTGTGGCACCCCCAATGCTGGCACCACCCCCTTCCTGGGGCCCCTTTTCTTCCCTGGCATCAGCTCACCTCTGCCCCGTGGCC
CCTCCCCCACTCTAATGCCAGTCCAGTTACTGATGCTTCCCGAGGCGGTGACTGCAGCCCACAGCCACCTGCGCCAGTGGCCCCACGTGG
ACTCCTGCCGGCCCCAGCTGGACACAGTGAATCAGGAACTCCTCCCTCCCCTCCACCTGCCTTGGGCTGGGGCTTCTGGCTCAGGGCACC
ACTGTCCCCCCAGATCCACGAGTTATCCTGTGTCCCCTCCTCCTCCTGCATCCCCTAGATGGCCTCCCCTCAGCCTGGTTGGAGCTGTGT
CCAGGTCCCCTGCACCTCCCCCTTGAGAAGCTCCCAGGGTTCCCTCTGGGCGATGTTAGTGATATGGCTGGATTTAACAGTGCTGAGCCC
TCGCCCACATCTGGGCGGCCCTGGGGTGGGGAGCAGGTGTCTGAGGTCAGGTCCCTGGAAAGAGACCCTGGGCCAGAGATTTGCGTGGGA
AGCTCCTGGGGTGGGCATGGGAGCTGGGCGGCAGCACACTTGCCACCGAGGCCTGGGGCAGCCCCATGAGGAGCTGTGCCCATATGGACC

>7441_7441_2_ATF6B-GLI4_ATF6B_chr6_32085635_ENST00000375203_GLI4_chr8_144356873_ENST00000344692_length(amino acids)=489AA_BP=
MVGGWGGKMAELMLLSEIADPTRFFTDNLLSPEDWGLQNSTLYSGLDEVAEEQTQLFRCPEQDVPFDGSSLDVGMDVSPSEPPWELLPIF
PDLQVKSEPSSPCSSSSLSSESSRLSTEPSSEALGVGEVLHVKTESLAPPLCLLGDDPTSSFETVQINVIPTSDDSSDVQTKIEPVSPCS
SVNSEASLLSADSSSQAFIGEEVLEVKTESLSPSGCLLWDVPAPSLGAVQISMGPSLDGSSGKALPTRKPPLQPKPVVLTTVPMPSRAVP
PSTTVLLQSLVQPPPVSPVVLIQGAIRVQPEGPAPSLPRPERKSIVPAPMPGNSCPPEVDAKLLKRQQRMIKNRESACQSRRKKKEYLQG
LEARLQAVLADNQQLRRENAALRRRLEALLAENSELKLGSGNRKVVCIMVFLLFIAFNFGPVSISEPPSAPISPRMNKGEPQPRRHLLGF

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ATF6B-GLI4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATF6B-GLI4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATF6B-GLI4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource