FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ATF6B-GNG4 (FusionGDB2 ID:7442)

Fusion Gene Summary for ATF6B-GNG4

check button Fusion gene summary
Fusion gene informationFusion gene name: ATF6B-GNG4
Fusion gene ID: 7442
HgeneTgene
Gene symbol

ATF6B

GNG4

Gene ID

1388

2786

Gene nameactivating transcription factor 6 betaG protein subunit gamma 4
SynonymsCREB-RP|CREBL1|G13-
Cytomap

6p21.32

1q42.3

Type of geneprotein-codingprotein-coding
Descriptioncyclic AMP-dependent transcription factor ATF-6 betaCreb-related proteincAMP response element-binding protein-related proteincAMP-dependent transcription factor ATF-6 betacAMP-responsive element-binding protein-like 1protein G13guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4guanine nucleotide binding protein (G protein), gamma 4guanine nucleotide binding protein 4
Modification date2020031320200313
UniProtAcc

Q99941

P50150

Ensembl transtripts involved in fusion geneENST00000293709, ENST00000375201, 
ENST00000375203, ENST00000383156, 
ENST00000425571, ENST00000427136, 
ENST00000435768, ENST00000439240, 
ENST00000467437, ENST00000468502, 
ENST00000475964, ENST00000476416, 
ENST00000547111, ENST00000549095, 
ENST00000553220, 		ENST00000366597, 
ENST00000366598, ENST00000391854, 
ENST00000450593, ENST00000484517, 
Fusion gene scores* DoF score4 X 4 X 3=485 X 4 X 3=60
# samples 45
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATF6B [Title/Abstract] AND GNG4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATF6B(32088183)-GNG4(235714533), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATF6B

GO:0045944

positive regulation of transcription by RNA polymerase II

14973138

HgeneATF6B

GO:1903892

negative regulation of ATF6-mediated unfolded protein response

9837962

HgeneATF6B

GO:1990440

positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

11256944


check buttonFusion gene breakpoints across ATF6B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across GNG4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAV747616ATF6Bchr6

32088183

-GNG4chr1

235714533

-


Top

Fusion Gene ORF analysis for ATF6B-GNG4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000293709ENST00000366597ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000293709ENST00000366598ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000293709ENST00000391854ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000293709ENST00000450593ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000375201ENST00000366597ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000375201ENST00000366598ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000375201ENST00000391854ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000375201ENST00000450593ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000375203ENST00000366597ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000375203ENST00000366598ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000375203ENST00000391854ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000375203ENST00000450593ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000383156ENST00000366597ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000383156ENST00000366598ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000383156ENST00000391854ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000383156ENST00000450593ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000425571ENST00000366597ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000425571ENST00000366598ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000425571ENST00000391854ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000425571ENST00000450593ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000427136ENST00000366597ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000427136ENST00000366598ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000427136ENST00000391854ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000427136ENST00000450593ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000435768ENST00000366597ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000435768ENST00000366598ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000435768ENST00000391854ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000435768ENST00000450593ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000439240ENST00000366597ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000439240ENST00000366598ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000439240ENST00000391854ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000439240ENST00000450593ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000467437ENST00000366597ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000467437ENST00000366598ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000467437ENST00000391854ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000467437ENST00000450593ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000468502ENST00000366597ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000468502ENST00000366598ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000468502ENST00000391854ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000468502ENST00000450593ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000475964ENST00000366597ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000475964ENST00000366598ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000475964ENST00000391854ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000475964ENST00000450593ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000476416ENST00000366597ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000476416ENST00000366598ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000476416ENST00000391854ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000476416ENST00000450593ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000547111ENST00000366597ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000547111ENST00000366598ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000547111ENST00000391854ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000547111ENST00000450593ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000549095ENST00000366597ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000549095ENST00000366598ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000549095ENST00000391854ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000549095ENST00000450593ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000553220ENST00000366597ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000553220ENST00000366598ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000553220ENST00000391854ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-3UTRENST00000553220ENST00000450593ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-intronENST00000293709ENST00000484517ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-intronENST00000375201ENST00000484517ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-intronENST00000375203ENST00000484517ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-intronENST00000383156ENST00000484517ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-intronENST00000425571ENST00000484517ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-intronENST00000427136ENST00000484517ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-intronENST00000435768ENST00000484517ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-intronENST00000439240ENST00000484517ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-intronENST00000467437ENST00000484517ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-intronENST00000468502ENST00000484517ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-intronENST00000475964ENST00000484517ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-intronENST00000476416ENST00000484517ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-intronENST00000547111ENST00000484517ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-intronENST00000549095ENST00000484517ATF6Bchr6

32088183

-GNG4chr1

235714533

-
intron-intronENST00000553220ENST00000484517ATF6Bchr6

32088183

-GNG4chr1

235714533

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for ATF6B-GNG4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for ATF6B-GNG4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:32088183/:235714533)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATF6B

Q99941

GNG4

P50150

FUNCTION: [Cyclic AMP-dependent transcription factor ATF-6 beta]: Precursor of the transcription factor form (Processed cyclic AMP-dependent transcription factor ATF-6 beta), which is embedded in the endoplasmic reticulum membrane (PubMed:11256944). Endoplasmic reticulum stress promotes processing of this form, releasing the transcription factor form that translocates into the nucleus, where it activates transcription of genes involved in the unfolded protein response (UPR) (PubMed:11256944). {ECO:0000269|PubMed:11256944}.; FUNCTION: [Processed cyclic AMP-dependent transcription factor ATF-6 beta]: Transcription factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress (PubMed:11256944). Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCAC[GA]-3') when NF-Y is bound to ERSE (PubMed:11256944). {ECO:0000269|PubMed:11256944}.FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. {ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for ATF6B-GNG4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for ATF6B-GNG4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ATF6B-GNG4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ATF6B-GNG4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource