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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATF7-EXOC4 (FusionGDB2 ID:7464)

Fusion Gene Summary for ATF7-EXOC4

check button Fusion gene summary
Fusion gene informationFusion gene name: ATF7-EXOC4
Fusion gene ID: 7464
HgeneTgene
Gene symbol

ATF7

EXOC4

Gene ID

11016

60412

Gene nameactivating transcription factor 7exocyst complex component 4
SynonymsATFASEC8|SEC8L1|Sec8p
Cytomap

12q13.13

7q33

Type of geneprotein-codingprotein-coding
Descriptioncyclic AMP-dependent transcription factor ATF-7transcription factor ATF-Aexocyst complex component 4SEC8-like 1exocyst complex component Sec8
Modification date2020031320200320
UniProtAcc

P17544

Q96A65

Ensembl transtripts involved in fusion geneENST00000328463, ENST00000415113, 
ENST00000420353, ENST00000456903, 
ENST00000548118, ENST00000548446, 
ENST00000591397, ENST00000546661, 
ENST00000460346, ENST00000393161, 
ENST00000541309, ENST00000545148, 
ENST00000253861, ENST00000539845, 
Fusion gene scores* DoF score12 X 11 X 10=132035 X 25 X 10=8750
# samples 1839
** MAII scorelog2(18/1320*10)=-2.87446911791614
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(39/8750*10)=-4.48773698785744
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATF7 [Title/Abstract] AND EXOC4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATF7(53994737)-EXOC4(133502078), # samples:1
Anticipated loss of major functional domain due to fusion event.ATF7-EXOC4 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ATF7-EXOC4 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATF7

GO:0006355

regulation of transcription, DNA-templated

8288576


check buttonFusion gene breakpoints across ATF7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across EXOC4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-A48C-01AATF7chr12

53994737

-EXOC4chr7

133502078

+


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Fusion Gene ORF analysis for ATF7-EXOC4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000328463ENST00000460346ATF7chr12

53994737

-EXOC4chr7

133502078

+
5CDS-3UTRENST00000415113ENST00000460346ATF7chr12

53994737

-EXOC4chr7

133502078

+
5CDS-3UTRENST00000420353ENST00000460346ATF7chr12

53994737

-EXOC4chr7

133502078

+
5CDS-3UTRENST00000456903ENST00000460346ATF7chr12

53994737

-EXOC4chr7

133502078

+
5CDS-3UTRENST00000548118ENST00000460346ATF7chr12

53994737

-EXOC4chr7

133502078

+
5CDS-3UTRENST00000548446ENST00000460346ATF7chr12

53994737

-EXOC4chr7

133502078

+
5CDS-3UTRENST00000591397ENST00000460346ATF7chr12

53994737

-EXOC4chr7

133502078

+
5CDS-intronENST00000328463ENST00000393161ATF7chr12

53994737

-EXOC4chr7

133502078

+
5CDS-intronENST00000328463ENST00000541309ATF7chr12

53994737

-EXOC4chr7

133502078

+
5CDS-intronENST00000328463ENST00000545148ATF7chr12

53994737

-EXOC4chr7

133502078

+
5CDS-intronENST00000415113ENST00000393161ATF7chr12

53994737

-EXOC4chr7

133502078

+
5CDS-intronENST00000415113ENST00000541309ATF7chr12

53994737

-EXOC4chr7

133502078

+
5CDS-intronENST00000415113ENST00000545148ATF7chr12

53994737

-EXOC4chr7

133502078

+
5CDS-intronENST00000420353ENST00000393161ATF7chr12

53994737

-EXOC4chr7

133502078

+
5CDS-intronENST00000420353ENST00000541309ATF7chr12

53994737

-EXOC4chr7

133502078

+
5CDS-intronENST00000420353ENST00000545148ATF7chr12

53994737

-EXOC4chr7

133502078

+
5CDS-intronENST00000456903ENST00000393161ATF7chr12

53994737

-EXOC4chr7

133502078

+
5CDS-intronENST00000456903ENST00000541309ATF7chr12

53994737

-EXOC4chr7

133502078

+
5CDS-intronENST00000456903ENST00000545148ATF7chr12

53994737

-EXOC4chr7

133502078

+
5CDS-intronENST00000548118ENST00000393161ATF7chr12

53994737

-EXOC4chr7

133502078

+
5CDS-intronENST00000548118ENST00000541309ATF7chr12

53994737

-EXOC4chr7

133502078

+
5CDS-intronENST00000548118ENST00000545148ATF7chr12

53994737

-EXOC4chr7

133502078

+
5CDS-intronENST00000548446ENST00000393161ATF7chr12

53994737

-EXOC4chr7

133502078

+
5CDS-intronENST00000548446ENST00000541309ATF7chr12

53994737

-EXOC4chr7

133502078

+
5CDS-intronENST00000548446ENST00000545148ATF7chr12

53994737

-EXOC4chr7

133502078

+
5CDS-intronENST00000591397ENST00000393161ATF7chr12

53994737

-EXOC4chr7

133502078

+
5CDS-intronENST00000591397ENST00000541309ATF7chr12

53994737

-EXOC4chr7

133502078

+
5CDS-intronENST00000591397ENST00000545148ATF7chr12

53994737

-EXOC4chr7

133502078

+
Frame-shiftENST00000328463ENST00000253861ATF7chr12

53994737

-EXOC4chr7

133502078

+
Frame-shiftENST00000328463ENST00000539845ATF7chr12

53994737

-EXOC4chr7

133502078

+
Frame-shiftENST00000415113ENST00000253861ATF7chr12

53994737

-EXOC4chr7

133502078

+
Frame-shiftENST00000415113ENST00000539845ATF7chr12

53994737

-EXOC4chr7

133502078

+
Frame-shiftENST00000420353ENST00000253861ATF7chr12

53994737

-EXOC4chr7

133502078

+
Frame-shiftENST00000420353ENST00000539845ATF7chr12

53994737

-EXOC4chr7

133502078

+
Frame-shiftENST00000456903ENST00000253861ATF7chr12

53994737

-EXOC4chr7

133502078

+
Frame-shiftENST00000456903ENST00000539845ATF7chr12

53994737

-EXOC4chr7

133502078

+
Frame-shiftENST00000548118ENST00000253861ATF7chr12

53994737

-EXOC4chr7

133502078

+
Frame-shiftENST00000548118ENST00000539845ATF7chr12

53994737

-EXOC4chr7

133502078

+
Frame-shiftENST00000548446ENST00000253861ATF7chr12

53994737

-EXOC4chr7

133502078

+
Frame-shiftENST00000548446ENST00000539845ATF7chr12

53994737

-EXOC4chr7

133502078

+
Frame-shiftENST00000591397ENST00000253861ATF7chr12

53994737

-EXOC4chr7

133502078

+
Frame-shiftENST00000591397ENST00000539845ATF7chr12

53994737

-EXOC4chr7

133502078

+
intron-3CDSENST00000546661ENST00000253861ATF7chr12

53994737

-EXOC4chr7

133502078

+
intron-3CDSENST00000546661ENST00000539845ATF7chr12

53994737

-EXOC4chr7

133502078

+
intron-3UTRENST00000546661ENST00000460346ATF7chr12

53994737

-EXOC4chr7

133502078

+
intron-intronENST00000546661ENST00000393161ATF7chr12

53994737

-EXOC4chr7

133502078

+
intron-intronENST00000546661ENST00000541309ATF7chr12

53994737

-EXOC4chr7

133502078

+
intron-intronENST00000546661ENST00000545148ATF7chr12

53994737

-EXOC4chr7

133502078

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ATF7-EXOC4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ATF7chr1253994736-EXOC4chr7133502077+8.63E-060.9999914
ATF7chr1253994736-EXOC4chr7133502077+8.63E-060.9999914

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ATF7-EXOC4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:53994737/:133502078)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATF7

P17544

EXOC4

Q96A65

FUNCTION: Stress-responsive chromatin regulator that plays a role in various biological processes including innate immunological memory, adipocyte differentiation or telomerase regulation (PubMed:29490055). In absence of stress, contributes to the formation of heterochromatin and heterochromatin-like structure by recruiting histone H3K9 tri- and di-methyltransferases thus silencing the transcription of target genes such as STAT1 in adipocytes, or genes involved in innate immunity in macrophages and adipocytes (By similarity). Stress induces ATF7 phosphorylation that disrupts interactions with histone methyltransferase and enhances the association with coactivators containing histone acetyltransferase and/or histone demethylase, leading to disruption of the heterochromatin-like structure and subsequently transcriptional activation (By similarity). In response to TNF-alpha, which is induced by various stresses, phosphorylated ATF7 and telomerase are released from telomeres leading to telomere shortening (PubMed:29490055). Plays also a role in maintaining epithelial regenerative capacity and protecting against cell death during intestinal epithelial damage and repair (By similarity). {ECO:0000250|UniProtKB:Q8R0S1, ECO:0000269|PubMed:29490055}.; FUNCTION: [Isoform 4]: Acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter.; FUNCTION: [Isoform 5]: Acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation. {ECO:0000269|PubMed:21858082}.FUNCTION: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ATF7-EXOC4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ATF7-EXOC4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATF7-EXOC4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATF7-EXOC4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource