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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RNF11-C8A (FusionGDB2 ID:74719)

Fusion Gene Summary for RNF11-C8A

check button Fusion gene summary
Fusion gene informationFusion gene name: RNF11-C8A
Fusion gene ID: 74719
HgeneTgene
Gene symbol

RNF11

C8A

Gene ID

26994

731

Gene namering finger protein 11complement C8 alpha chain
SynonymsCGI-123|SID1669-
Cytomap

1p32.3

1p32.2

Type of geneprotein-codingprotein-coding
DescriptionRING finger protein 11complement component C8 alpha chaincomplement component 8 alpha subunitcomplement component 8 subunit alphacomplement component 8, alpha polypeptide
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000494873, ENST00000242719, 
ENST00000361249, 
Fusion gene scores* DoF score5 X 5 X 3=754 X 6 X 3=72
# samples 75
** MAII scorelog2(7/75*10)=-0.0995356735509144
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/72*10)=-0.526068811667588
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RNF11 [Title/Abstract] AND C8A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRNF11(51702551)-C8A(57347118), # samples:3
Anticipated loss of major functional domain due to fusion event.RNF11-C8A seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRNF11

GO:0006511

ubiquitin-dependent protein catabolic process

14755250

HgeneRNF11

GO:0051865

protein autoubiquitination

24105792

TgeneC8A

GO:0006956

complement activation

12413696


check buttonFusion gene breakpoints across RNF11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across C8A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-04-1341-01ARNF11chr1

51702551

-C8Achr1

57347118

+
ChimerDB4OVTCGA-04-1341-01ARNF11chr1

51702551

+C8Achr1

57347118

+
ChimerDB4OVTCGA-04-1341-01ARNF11chr1

51702551

+C8Achr1

57349154

+
ChimerDB4OVTCGA-04-1341RNF11chr1

51702551

+C8Achr1

57347117

+
ChimerDB4OVTCGA-04-1341RNF11chr1

51702551

+C8Achr1

57349153

+


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Fusion Gene ORF analysis for RNF11-C8A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000494873ENST00000361249RNF11chr1

51702551

+C8Achr1

57347118

+
3UTR-3CDSENST00000494873ENST00000361249RNF11chr1

51702551

+C8Achr1

57349154

+
3UTR-3CDSENST00000494873ENST00000361249RNF11chr1

51702551

+C8Achr1

57347117

+
3UTR-3CDSENST00000494873ENST00000361249RNF11chr1

51702551

+C8Achr1

57349153

+
Frame-shiftENST00000242719ENST00000361249RNF11chr1

51702551

+C8Achr1

57347118

+
Frame-shiftENST00000242719ENST00000361249RNF11chr1

51702551

+C8Achr1

57347117

+
In-frameENST00000242719ENST00000361249RNF11chr1

51702551

+C8Achr1

57349154

+
In-frameENST00000242719ENST00000361249RNF11chr1

51702551

+C8Achr1

57349153

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000242719RNF11chr151702551+ENST00000361249C8Achr157349153+22156094441709421
ENST00000242719RNF11chr151702551+ENST00000361249C8Achr157349154+22156094441709421

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000242719ENST00000361249RNF11chr151702551+C8Achr157349153+0.0031578230.99684215
ENST00000242719ENST00000361249RNF11chr151702551+C8Achr157349154+0.0031578230.99684215

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Fusion Genomic Features for RNF11-C8A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RNF11chr151702551+C8Achr157347117+2.55E-050.9999745
RNF11chr151702551+C8Achr157347117+2.55E-050.9999745
RNF11chr151702551+C8Achr157349153+3.77E-081
RNF11chr151702551+C8Achr157349153+3.77E-081
RNF11chr151702551+C8Achr157347117+2.55E-050.9999745
RNF11chr151702551+C8Achr157347117+2.55E-050.9999745
RNF11chr151702551+C8Achr157349153+3.77E-081
RNF11chr151702551+C8Achr157349153+3.77E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for RNF11-C8A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:51702551/chr1:57347118)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRNF11chr1:51702551chr1:57349153ENST00000242719+1337_4041155.0MotifNote=PPxY motif
HgeneRNF11chr1:51702551chr1:57349154ENST00000242719+1337_4041155.0MotifNote=PPxY motif
TgeneC8Achr1:51702551chr1:57349153ENST00000361249411499_529218585.0DomainNote=EGF-like
TgeneC8Achr1:51702551chr1:57349153ENST00000361249411539_583218585.0DomainTSP type-1 2
TgeneC8Achr1:51702551chr1:57349154ENST00000361249411499_529218585.0DomainNote=EGF-like
TgeneC8Achr1:51702551chr1:57349154ENST00000361249411539_583218585.0DomainTSP type-1 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRNF11chr1:51702551chr1:57349153ENST00000242719+1399_14041155.0Zinc fingerRING-type
HgeneRNF11chr1:51702551chr1:57349154ENST00000242719+1399_14041155.0Zinc fingerRING-type
TgeneC8Achr1:51702551chr1:57349153ENST00000361249411135_498218585.0DomainMACPF
TgeneC8Achr1:51702551chr1:57349153ENST0000036124941138_91218585.0DomainTSP type-1 1
TgeneC8Achr1:51702551chr1:57349153ENST0000036124941194_132218585.0DomainLDL-receptor class A
TgeneC8Achr1:51702551chr1:57349154ENST00000361249411135_498218585.0DomainMACPF
TgeneC8Achr1:51702551chr1:57349154ENST0000036124941138_91218585.0DomainTSP type-1 1
TgeneC8Achr1:51702551chr1:57349154ENST0000036124941194_132218585.0DomainLDL-receptor class A


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Fusion Gene Sequence for RNF11-C8A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>74719_74719_1_RNF11-C8A_RNF11_chr1_51702551_ENST00000242719_C8A_chr1_57349153_ENST00000361249_length(transcript)=2215nt_BP=609nt
GCAGTGCCCGAGCCGGCCTCGTTCTGGCTGCCGCCGTCTCGCTGAGGCGGAGTAGGATGAGGCCCGCGGCCGTGGCTCCGGCGTCGGCGG
GGGCAGCAGCAGCTGAGGCAGCAGCTGAGGCAGCCGCGACGGCCGCGCCCCCCCCCGCTGACCTGGATTAGGCCCAGCAGCTCCGTGGCC
GCCGCCGCCCCGCGGGGGGGCGGGGTGGGGAAGTGCTTCGTCTCCCCGCCCCCCCCCCCCCATCGCTGCCTCGCAGGAGGCGAACGCCGC
GACCCCAGCGGAGCCCGCGGCCCAGCCTTGATCCCCCAACCCCGGGGGCTGGCATGAGCGGCCCCTCGGCGGCACCGTGGGGCGGTGGAG
TCGCCTCCGCCTGATCCCCGGCCTGTCGCCCGACCCCACCTCGCCAACCGAGGCGGACCGCGGAGTGTGCGAACGACCCCACCGCTGCTT
TCTCCTCCCCCAGATCACGCACCCCAGCTCCGGAAGATGGGGAACTGCCTCAAATCCCCCACCTCGGATGACATCTCCCTGCTTCACGAG
TCTCAGTCCGACCGGGCTAGCTTTGGCGAGGGGACGGAGCCGGATCAGGAGCCGCCGCCGCCATATCAGGCCCTGGCAGATACTGGAATC
TCCTCAGAGTTTTATGATAATGCAAATGACCTTCTTTCCAAAGTTAAAAAAGACAAGTCTGACTCATTTGGAGTGACCATCGGCATAGGC
CCAGCCGGCAGCCCTTTATTGGTGGGTGTAGGTGTATCCCACTCACAAGACACTTCATTCTTGAACGAATTAAACAAGTATAATGAGAAG
AAATTCATTTTCACAAGAATCTTCACAAAGGTGCAGACTGCACATTTTAAGATGAGGAAGGATGACATTATGCTGGATGAAGGAATGCTG
CAGTCATTAATGGAGCTTCCAGATCAGTACAATTATGGCATGTATGCCAAGTTCATCAATGACTATGGCACCCATTACATCACATCTGGA
TCCATGGGTGGCATTTATGAATATATCCTGGTGATTGACAAAGCAAAAATGGAATCCCTTGGTATTACCAGCAGAGATATCACGACATGT
TTTGGAGGCTCCTTGGGCATTCAATATGAAGACAAAATAAATGTTGGTGGAGGTTTATCAGGAGACCATTGTAAAAAATTTGGAGGTGGC
AAAACTGAAAGGGCCAGGAAGGCCATGGCTGTGGAAGACATTATTTCTCGGGTGCGAGGTGGCAGTTCTGGCTGGAGCGGTGGCTTGGCA
CAGAACAGGAGCACCATTACATACCGTTCCTGGGGGAGGTCATTAAAGTATAATCCTGTTGTTATCGATTTTGAGATGCAGCCTATCCAC
GAGGTGCTGCGGCACACAAGCCTGGGGCCTCTGGAGGCCAAGCGCCAGAACCTGCGCCGCGCCTTGGACCAGTATCTGATGGAATTCAAT
GCCTGCCGATGTGGGCCTTGCTTCAACAATGGGGTGCCCATCCTCGAGGGCACCAGCTGCAGGTGCCAGTGCCGCCTGGGTAGCTTGGGT
GCTGCCTGTGAGCAAACACAGACAGAAGGAGCCAAAGCAGATGGGAGCTGGAGTTGCTGGAGCTCCTGGTCTGTATGCAGAGCAGGCATC
CAGGAAAGGAGAAGAGAGTGTGACAATCCAGCACCTCAGAATGGAGGGGCCTCGTGTCCAGGGCGGAAAGTACAGACGCAGGCTTGCTGA
GGGCCTCTGGACACAGGCTGGACCAGATGCTGTGGATGTCGACCCCTGCACTGACTATTGGATAAAGACTTCTTTCAACTAAGAGAAGAT
GCAAATCAGCACACTTTTTTCTTTGTTCTGCCAGCTTCCAGGCCTAAGACTAGGTTTTGCTGTCTACAGCCAACTATTCTATTAGTTACA
AAACTCAATCATTTTATTCAGCAACTGGATGTTGACTGTTAACTAGAAGCTCTGTCCTACTTACAGCACTTTGGATCATCAAAAAAATAA
AGTAAAATAGAAAACTGAGAAAACTCAATCCATGACCAGGGAGAACTTACAGGATGTTAGAGACAAAACAAGCAGACACCTGAAACAATC
AACGCCCAATAAAACAAAGTAGGATGAAAATTCTCTTAGTTCTTTGATAACAATTTGTTCACTCATAGAAACATTATTAATTGGTAGGGT

>74719_74719_1_RNF11-C8A_RNF11_chr1_51702551_ENST00000242719_C8A_chr1_57349153_ENST00000361249_length(amino acids)=421AA_BP=54
MLSPPPDHAPQLRKMGNCLKSPTSDDISLLHESQSDRASFGEGTEPDQEPPPPYQALADTGISSEFYDNANDLLSKVKKDKSDSFGVTIG
IGPAGSPLLVGVGVSHSQDTSFLNELNKYNEKKFIFTRIFTKVQTAHFKMRKDDIMLDEGMLQSLMELPDQYNYGMYAKFINDYGTHYIT
SGSMGGIYEYILVIDKAKMESLGITSRDITTCFGGSLGIQYEDKINVGGGLSGDHCKKFGGGKTERARKAMAVEDIISRVRGGSSGWSGG
LAQNRSTITYRSWGRSLKYNPVVIDFEMQPIHEVLRHTSLGPLEAKRQNLRRALDQYLMEFNACRCGPCFNNGVPILEGTSCRCQCRLGS

--------------------------------------------------------------
>74719_74719_2_RNF11-C8A_RNF11_chr1_51702551_ENST00000242719_C8A_chr1_57349154_ENST00000361249_length(transcript)=2215nt_BP=609nt
GCAGTGCCCGAGCCGGCCTCGTTCTGGCTGCCGCCGTCTCGCTGAGGCGGAGTAGGATGAGGCCCGCGGCCGTGGCTCCGGCGTCGGCGG
GGGCAGCAGCAGCTGAGGCAGCAGCTGAGGCAGCCGCGACGGCCGCGCCCCCCCCCGCTGACCTGGATTAGGCCCAGCAGCTCCGTGGCC
GCCGCCGCCCCGCGGGGGGGCGGGGTGGGGAAGTGCTTCGTCTCCCCGCCCCCCCCCCCCCATCGCTGCCTCGCAGGAGGCGAACGCCGC
GACCCCAGCGGAGCCCGCGGCCCAGCCTTGATCCCCCAACCCCGGGGGCTGGCATGAGCGGCCCCTCGGCGGCACCGTGGGGCGGTGGAG
TCGCCTCCGCCTGATCCCCGGCCTGTCGCCCGACCCCACCTCGCCAACCGAGGCGGACCGCGGAGTGTGCGAACGACCCCACCGCTGCTT
TCTCCTCCCCCAGATCACGCACCCCAGCTCCGGAAGATGGGGAACTGCCTCAAATCCCCCACCTCGGATGACATCTCCCTGCTTCACGAG
TCTCAGTCCGACCGGGCTAGCTTTGGCGAGGGGACGGAGCCGGATCAGGAGCCGCCGCCGCCATATCAGGCCCTGGCAGATACTGGAATC
TCCTCAGAGTTTTATGATAATGCAAATGACCTTCTTTCCAAAGTTAAAAAAGACAAGTCTGACTCATTTGGAGTGACCATCGGCATAGGC
CCAGCCGGCAGCCCTTTATTGGTGGGTGTAGGTGTATCCCACTCACAAGACACTTCATTCTTGAACGAATTAAACAAGTATAATGAGAAG
AAATTCATTTTCACAAGAATCTTCACAAAGGTGCAGACTGCACATTTTAAGATGAGGAAGGATGACATTATGCTGGATGAAGGAATGCTG
CAGTCATTAATGGAGCTTCCAGATCAGTACAATTATGGCATGTATGCCAAGTTCATCAATGACTATGGCACCCATTACATCACATCTGGA
TCCATGGGTGGCATTTATGAATATATCCTGGTGATTGACAAAGCAAAAATGGAATCCCTTGGTATTACCAGCAGAGATATCACGACATGT
TTTGGAGGCTCCTTGGGCATTCAATATGAAGACAAAATAAATGTTGGTGGAGGTTTATCAGGAGACCATTGTAAAAAATTTGGAGGTGGC
AAAACTGAAAGGGCCAGGAAGGCCATGGCTGTGGAAGACATTATTTCTCGGGTGCGAGGTGGCAGTTCTGGCTGGAGCGGTGGCTTGGCA
CAGAACAGGAGCACCATTACATACCGTTCCTGGGGGAGGTCATTAAAGTATAATCCTGTTGTTATCGATTTTGAGATGCAGCCTATCCAC
GAGGTGCTGCGGCACACAAGCCTGGGGCCTCTGGAGGCCAAGCGCCAGAACCTGCGCCGCGCCTTGGACCAGTATCTGATGGAATTCAAT
GCCTGCCGATGTGGGCCTTGCTTCAACAATGGGGTGCCCATCCTCGAGGGCACCAGCTGCAGGTGCCAGTGCCGCCTGGGTAGCTTGGGT
GCTGCCTGTGAGCAAACACAGACAGAAGGAGCCAAAGCAGATGGGAGCTGGAGTTGCTGGAGCTCCTGGTCTGTATGCAGAGCAGGCATC
CAGGAAAGGAGAAGAGAGTGTGACAATCCAGCACCTCAGAATGGAGGGGCCTCGTGTCCAGGGCGGAAAGTACAGACGCAGGCTTGCTGA
GGGCCTCTGGACACAGGCTGGACCAGATGCTGTGGATGTCGACCCCTGCACTGACTATTGGATAAAGACTTCTTTCAACTAAGAGAAGAT
GCAAATCAGCACACTTTTTTCTTTGTTCTGCCAGCTTCCAGGCCTAAGACTAGGTTTTGCTGTCTACAGCCAACTATTCTATTAGTTACA
AAACTCAATCATTTTATTCAGCAACTGGATGTTGACTGTTAACTAGAAGCTCTGTCCTACTTACAGCACTTTGGATCATCAAAAAAATAA
AGTAAAATAGAAAACTGAGAAAACTCAATCCATGACCAGGGAGAACTTACAGGATGTTAGAGACAAAACAAGCAGACACCTGAAACAATC
AACGCCCAATAAAACAAAGTAGGATGAAAATTCTCTTAGTTCTTTGATAACAATTTGTTCACTCATAGAAACATTATTAATTGGTAGGGT

>74719_74719_2_RNF11-C8A_RNF11_chr1_51702551_ENST00000242719_C8A_chr1_57349154_ENST00000361249_length(amino acids)=421AA_BP=54
MLSPPPDHAPQLRKMGNCLKSPTSDDISLLHESQSDRASFGEGTEPDQEPPPPYQALADTGISSEFYDNANDLLSKVKKDKSDSFGVTIG
IGPAGSPLLVGVGVSHSQDTSFLNELNKYNEKKFIFTRIFTKVQTAHFKMRKDDIMLDEGMLQSLMELPDQYNYGMYAKFINDYGTHYIT
SGSMGGIYEYILVIDKAKMESLGITSRDITTCFGGSLGIQYEDKINVGGGLSGDHCKKFGGGKTERARKAMAVEDIISRVRGGSSGWSGG
LAQNRSTITYRSWGRSLKYNPVVIDFEMQPIHEVLRHTSLGPLEAKRQNLRRALDQYLMEFNACRCGPCFNNGVPILEGTSCRCQCRLGS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RNF11-C8A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RNF11-C8A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RNF11-C8A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource