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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RNF121-ANO1 (FusionGDB2 ID:74725)

Fusion Gene Summary for RNF121-ANO1

check button Fusion gene summary
Fusion gene informationFusion gene name: RNF121-ANO1
Fusion gene ID: 74725
HgeneTgene
Gene symbol

RNF121

ANO1

Gene ID

55298

55107

Gene namering finger protein 121anoctamin 1
Synonyms-DOG1|ORAOV2|TAOS2|TMEM16A
Cytomap

11q13.4

11q13.3

Type of geneprotein-codingprotein-coding
DescriptionRING finger protein 121anoctamin-1Ca2+-activated Cl- channelanoctamin 1, calcium activated chloride channelcalcium activated chloride channeldiscovered on gastrointestinal stromal tumors protein 1oral cancer overexpressed 2transmembrane protein 16A (eight membrane-spannin
Modification date2020031320200313
UniProtAcc.

Q9NW15

Ensembl transtripts involved in fusion geneENST00000490867, ENST00000361756, 
ENST00000393713, ENST00000530137, 
ENST00000533380, ENST00000545854, 
ENST00000355303, ENST00000316296, 
ENST00000398543, ENST00000530676, 
ENST00000538023, ENST00000525494, 
ENST00000531349, 
Fusion gene scores* DoF score22 X 8 X 11=193619 X 28 X 10=5320
# samples 2736
** MAII scorelog2(27/1936*10)=-2.84204764022376
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(36/5320*10)=-3.88535743405888
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RNF121 [Title/Abstract] AND ANO1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRNF121(71671937)-ANO1(69933858), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneANO1

GO:0006812

cation transport

22946059


check buttonFusion gene breakpoints across RNF121 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ANO1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A7-A26G-01ARNF121chr11

71671937

-ANO1chr11

69933858

+
ChimerDB4BRCATCGA-A7-A26G-01ARNF121chr11

71671937

+ANO1chr11

69933858

+


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Fusion Gene ORF analysis for RNF121-ANO1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000490867ENST00000355303RNF121chr11

71671937

+ANO1chr11

69933858

+
3UTR-5UTRENST00000490867ENST00000316296RNF121chr11

71671937

+ANO1chr11

69933858

+
3UTR-5UTRENST00000490867ENST00000398543RNF121chr11

71671937

+ANO1chr11

69933858

+
3UTR-5UTRENST00000490867ENST00000530676RNF121chr11

71671937

+ANO1chr11

69933858

+
3UTR-5UTRENST00000490867ENST00000538023RNF121chr11

71671937

+ANO1chr11

69933858

+
3UTR-intronENST00000490867ENST00000525494RNF121chr11

71671937

+ANO1chr11

69933858

+
3UTR-intronENST00000490867ENST00000531349RNF121chr11

71671937

+ANO1chr11

69933858

+
5CDS-5UTRENST00000361756ENST00000316296RNF121chr11

71671937

+ANO1chr11

69933858

+
5CDS-5UTRENST00000361756ENST00000398543RNF121chr11

71671937

+ANO1chr11

69933858

+
5CDS-5UTRENST00000361756ENST00000530676RNF121chr11

71671937

+ANO1chr11

69933858

+
5CDS-5UTRENST00000361756ENST00000538023RNF121chr11

71671937

+ANO1chr11

69933858

+
5CDS-5UTRENST00000393713ENST00000316296RNF121chr11

71671937

+ANO1chr11

69933858

+
5CDS-5UTRENST00000393713ENST00000398543RNF121chr11

71671937

+ANO1chr11

69933858

+
5CDS-5UTRENST00000393713ENST00000530676RNF121chr11

71671937

+ANO1chr11

69933858

+
5CDS-5UTRENST00000393713ENST00000538023RNF121chr11

71671937

+ANO1chr11

69933858

+
5CDS-5UTRENST00000530137ENST00000316296RNF121chr11

71671937

+ANO1chr11

69933858

+
5CDS-5UTRENST00000530137ENST00000398543RNF121chr11

71671937

+ANO1chr11

69933858

+
5CDS-5UTRENST00000530137ENST00000530676RNF121chr11

71671937

+ANO1chr11

69933858

+
5CDS-5UTRENST00000530137ENST00000538023RNF121chr11

71671937

+ANO1chr11

69933858

+
5CDS-5UTRENST00000533380ENST00000316296RNF121chr11

71671937

+ANO1chr11

69933858

+
5CDS-5UTRENST00000533380ENST00000398543RNF121chr11

71671937

+ANO1chr11

69933858

+
5CDS-5UTRENST00000533380ENST00000530676RNF121chr11

71671937

+ANO1chr11

69933858

+
5CDS-5UTRENST00000533380ENST00000538023RNF121chr11

71671937

+ANO1chr11

69933858

+
5CDS-intronENST00000361756ENST00000525494RNF121chr11

71671937

+ANO1chr11

69933858

+
5CDS-intronENST00000361756ENST00000531349RNF121chr11

71671937

+ANO1chr11

69933858

+
5CDS-intronENST00000393713ENST00000525494RNF121chr11

71671937

+ANO1chr11

69933858

+
5CDS-intronENST00000393713ENST00000531349RNF121chr11

71671937

+ANO1chr11

69933858

+
5CDS-intronENST00000530137ENST00000525494RNF121chr11

71671937

+ANO1chr11

69933858

+
5CDS-intronENST00000530137ENST00000531349RNF121chr11

71671937

+ANO1chr11

69933858

+
5CDS-intronENST00000533380ENST00000525494RNF121chr11

71671937

+ANO1chr11

69933858

+
5CDS-intronENST00000533380ENST00000531349RNF121chr11

71671937

+ANO1chr11

69933858

+
5UTR-3CDSENST00000545854ENST00000355303RNF121chr11

71671937

+ANO1chr11

69933858

+
5UTR-5UTRENST00000545854ENST00000316296RNF121chr11

71671937

+ANO1chr11

69933858

+
5UTR-5UTRENST00000545854ENST00000398543RNF121chr11

71671937

+ANO1chr11

69933858

+
5UTR-5UTRENST00000545854ENST00000530676RNF121chr11

71671937

+ANO1chr11

69933858

+
5UTR-5UTRENST00000545854ENST00000538023RNF121chr11

71671937

+ANO1chr11

69933858

+
5UTR-intronENST00000545854ENST00000525494RNF121chr11

71671937

+ANO1chr11

69933858

+
5UTR-intronENST00000545854ENST00000531349RNF121chr11

71671937

+ANO1chr11

69933858

+
In-frameENST00000361756ENST00000355303RNF121chr11

71671937

+ANO1chr11

69933858

+
In-frameENST00000393713ENST00000355303RNF121chr11

71671937

+ANO1chr11

69933858

+
In-frameENST00000530137ENST00000355303RNF121chr11

71671937

+ANO1chr11

69933858

+
In-frameENST00000533380ENST00000355303RNF121chr11

71671937

+ANO1chr11

69933858

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000361756RNF121chr1171671937+ENST00000355303ANO1chr1169933858+498160431934561045
ENST00000533380RNF121chr1171671937+ENST00000355303ANO1chr1169933858+46122355530871010
ENST00000393713RNF121chr1171671937+ENST00000355303ANO1chr1169933858+46102335330851010
ENST00000530137RNF121chr1171671937+ENST00000355303ANO1chr1169933858+4562185530371010

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000361756ENST00000355303RNF121chr1171671937+ANO1chr1169933858+0.00191950.9980805
ENST00000533380ENST00000355303RNF121chr1171671937+ANO1chr1169933858+0.0011864080.9988136
ENST00000393713ENST00000355303RNF121chr1171671937+ANO1chr1169933858+0.0011875760.99881244
ENST00000530137ENST00000355303RNF121chr1171671937+ANO1chr1169933858+0.0011480550.9988519

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Fusion Genomic Features for RNF121-ANO1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RNF121chr1171671937+ANO1chr1169933857+3.84E-081
RNF121chr1171671937+ANO1chr1169933857+3.84E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for RNF121-ANO1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:71671937/chr11:69933858)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ANO1

Q9NW15

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1. {ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:22946059}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRNF121chr11:71671937chr11:69933858ENST00000361756+3950_7081328.0TransmembraneHelical
TgeneANO1chr11:71671937chr11:69933858ENST00000316296017355_4068643.0Topological domainExtracellular
TgeneANO1chr11:71671937chr11:69933858ENST00000316296017428_5198643.0Topological domainCytoplasmic
TgeneANO1chr11:71671937chr11:69933858ENST00000316296017541_5688643.0Topological domainExtracellular
TgeneANO1chr11:71671937chr11:69933858ENST00000316296017590_6078643.0Topological domainCytoplasmic
TgeneANO1chr11:71671937chr11:69933858ENST00000316296017629_6578643.0Topological domainExtracellular
TgeneANO1chr11:71671937chr11:69933858ENST00000316296017679_7258643.0Topological domainCytoplasmic
TgeneANO1chr11:71671937chr11:69933858ENST00000316296017768_7848643.0Topological domainCytoplasmic
TgeneANO1chr11:71671937chr11:69933858ENST00000316296017806_8928643.0Topological domainExtracellular
TgeneANO1chr11:71671937chr11:69933858ENST00000316296017914_9868643.0Topological domainCytoplasmic
TgeneANO1chr11:71671937chr11:69933858ENST00000355303026355_40636987.0Topological domainExtracellular
TgeneANO1chr11:71671937chr11:69933858ENST00000355303026428_51936987.0Topological domainCytoplasmic
TgeneANO1chr11:71671937chr11:69933858ENST00000355303026541_56836987.0Topological domainExtracellular
TgeneANO1chr11:71671937chr11:69933858ENST00000355303026590_60736987.0Topological domainCytoplasmic
TgeneANO1chr11:71671937chr11:69933858ENST00000355303026629_65736987.0Topological domainExtracellular
TgeneANO1chr11:71671937chr11:69933858ENST00000355303026679_72536987.0Topological domainCytoplasmic
TgeneANO1chr11:71671937chr11:69933858ENST00000355303026768_78436987.0Topological domainCytoplasmic
TgeneANO1chr11:71671937chr11:69933858ENST00000355303026806_89236987.0Topological domainExtracellular
TgeneANO1chr11:71671937chr11:69933858ENST00000355303026914_98636987.0Topological domainCytoplasmic
TgeneANO1chr11:71671937chr11:69933858ENST000003985430241_3330841.0Topological domainCytoplasmic
TgeneANO1chr11:71671937chr11:69933858ENST00000398543024355_4060841.0Topological domainExtracellular
TgeneANO1chr11:71671937chr11:69933858ENST00000398543024428_5190841.0Topological domainCytoplasmic
TgeneANO1chr11:71671937chr11:69933858ENST00000398543024541_5680841.0Topological domainExtracellular
TgeneANO1chr11:71671937chr11:69933858ENST00000398543024590_6070841.0Topological domainCytoplasmic
TgeneANO1chr11:71671937chr11:69933858ENST00000398543024629_6570841.0Topological domainExtracellular
TgeneANO1chr11:71671937chr11:69933858ENST00000398543024679_7250841.0Topological domainCytoplasmic
TgeneANO1chr11:71671937chr11:69933858ENST00000398543024768_7840841.0Topological domainCytoplasmic
TgeneANO1chr11:71671937chr11:69933858ENST00000398543024806_8920841.0Topological domainExtracellular
TgeneANO1chr11:71671937chr11:69933858ENST00000398543024914_9860841.0Topological domainCytoplasmic
TgeneANO1chr11:71671937chr11:69933858ENST000005306760251_3330819.3333333333334Topological domainCytoplasmic
TgeneANO1chr11:71671937chr11:69933858ENST00000530676025355_4060819.3333333333334Topological domainExtracellular
TgeneANO1chr11:71671937chr11:69933858ENST00000530676025428_5190819.3333333333334Topological domainCytoplasmic
TgeneANO1chr11:71671937chr11:69933858ENST00000530676025541_5680819.3333333333334Topological domainExtracellular
TgeneANO1chr11:71671937chr11:69933858ENST00000530676025590_6070819.3333333333334Topological domainCytoplasmic
TgeneANO1chr11:71671937chr11:69933858ENST00000530676025629_6570819.3333333333334Topological domainExtracellular
TgeneANO1chr11:71671937chr11:69933858ENST00000530676025679_7250819.3333333333334Topological domainCytoplasmic
TgeneANO1chr11:71671937chr11:69933858ENST00000530676025768_7840819.3333333333334Topological domainCytoplasmic
TgeneANO1chr11:71671937chr11:69933858ENST00000530676025806_8920819.3333333333334Topological domainExtracellular
TgeneANO1chr11:71671937chr11:69933858ENST00000530676025914_9860819.3333333333334Topological domainCytoplasmic
TgeneANO1chr11:71671937chr11:69933858ENST00000316296017334_3548643.0TransmembraneHelical
TgeneANO1chr11:71671937chr11:69933858ENST00000316296017407_4278643.0TransmembraneHelical
TgeneANO1chr11:71671937chr11:69933858ENST00000316296017520_5408643.0TransmembraneHelical
TgeneANO1chr11:71671937chr11:69933858ENST00000316296017569_5898643.0TransmembraneHelical
TgeneANO1chr11:71671937chr11:69933858ENST00000316296017608_6288643.0TransmembraneHelical
TgeneANO1chr11:71671937chr11:69933858ENST00000316296017658_6788643.0TransmembraneHelical
TgeneANO1chr11:71671937chr11:69933858ENST00000316296017726_7468643.0TransmembraneHelical
TgeneANO1chr11:71671937chr11:69933858ENST00000316296017747_7678643.0TransmembraneHelical
TgeneANO1chr11:71671937chr11:69933858ENST00000316296017785_8058643.0TransmembraneHelical
TgeneANO1chr11:71671937chr11:69933858ENST00000316296017893_9138643.0TransmembraneHelical
TgeneANO1chr11:71671937chr11:69933858ENST00000355303026334_35436987.0TransmembraneHelical
TgeneANO1chr11:71671937chr11:69933858ENST00000355303026407_42736987.0TransmembraneHelical
TgeneANO1chr11:71671937chr11:69933858ENST00000355303026520_54036987.0TransmembraneHelical
TgeneANO1chr11:71671937chr11:69933858ENST00000355303026569_58936987.0TransmembraneHelical
TgeneANO1chr11:71671937chr11:69933858ENST00000355303026608_62836987.0TransmembraneHelical
TgeneANO1chr11:71671937chr11:69933858ENST00000355303026658_67836987.0TransmembraneHelical
TgeneANO1chr11:71671937chr11:69933858ENST00000355303026726_74636987.0TransmembraneHelical
TgeneANO1chr11:71671937chr11:69933858ENST00000355303026747_76736987.0TransmembraneHelical
TgeneANO1chr11:71671937chr11:69933858ENST00000355303026785_80536987.0TransmembraneHelical
TgeneANO1chr11:71671937chr11:69933858ENST00000355303026893_91336987.0TransmembraneHelical
TgeneANO1chr11:71671937chr11:69933858ENST00000398543024334_3540841.0TransmembraneHelical
TgeneANO1chr11:71671937chr11:69933858ENST00000398543024407_4270841.0TransmembraneHelical
TgeneANO1chr11:71671937chr11:69933858ENST00000398543024520_5400841.0TransmembraneHelical
TgeneANO1chr11:71671937chr11:69933858ENST00000398543024569_5890841.0TransmembraneHelical
TgeneANO1chr11:71671937chr11:69933858ENST00000398543024608_6280841.0TransmembraneHelical
TgeneANO1chr11:71671937chr11:69933858ENST00000398543024658_6780841.0TransmembraneHelical
TgeneANO1chr11:71671937chr11:69933858ENST00000398543024726_7460841.0TransmembraneHelical
TgeneANO1chr11:71671937chr11:69933858ENST00000398543024747_7670841.0TransmembraneHelical
TgeneANO1chr11:71671937chr11:69933858ENST00000398543024785_8050841.0TransmembraneHelical
TgeneANO1chr11:71671937chr11:69933858ENST00000398543024893_9130841.0TransmembraneHelical
TgeneANO1chr11:71671937chr11:69933858ENST00000530676025334_3540819.3333333333334TransmembraneHelical
TgeneANO1chr11:71671937chr11:69933858ENST00000530676025407_4270819.3333333333334TransmembraneHelical
TgeneANO1chr11:71671937chr11:69933858ENST00000530676025520_5400819.3333333333334TransmembraneHelical
TgeneANO1chr11:71671937chr11:69933858ENST00000530676025569_5890819.3333333333334TransmembraneHelical
TgeneANO1chr11:71671937chr11:69933858ENST00000530676025608_6280819.3333333333334TransmembraneHelical
TgeneANO1chr11:71671937chr11:69933858ENST00000530676025658_6780819.3333333333334TransmembraneHelical
TgeneANO1chr11:71671937chr11:69933858ENST00000530676025726_7460819.3333333333334TransmembraneHelical
TgeneANO1chr11:71671937chr11:69933858ENST00000530676025747_7670819.3333333333334TransmembraneHelical
TgeneANO1chr11:71671937chr11:69933858ENST00000530676025785_8050819.3333333333334TransmembraneHelical
TgeneANO1chr11:71671937chr11:69933858ENST00000530676025893_9130819.3333333333334TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRNF121chr11:71671937chr11:69933858ENST00000361756+39100_12081328.0TransmembraneHelical
HgeneRNF121chr11:71671937chr11:69933858ENST00000361756+39148_16881328.0TransmembraneHelical
HgeneRNF121chr11:71671937chr11:69933858ENST00000361756+39172_19281328.0TransmembraneHelical
HgeneRNF121chr11:71671937chr11:69933858ENST00000361756+39306_32681328.0TransmembraneHelical
HgeneRNF121chr11:71671937chr11:69933858ENST00000361756+3979_9981328.0TransmembraneHelical
HgeneRNF121chr11:71671937chr11:69933858ENST00000361756+39226_27681328.0Zinc fingerRING-type%3B atypical
TgeneANO1chr11:71671937chr11:69933858ENST000003162960171_3338643.0Topological domainCytoplasmic
TgeneANO1chr11:71671937chr11:69933858ENST000003553030261_33336987.0Topological domainCytoplasmic


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Fusion Gene Sequence for RNF121-ANO1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>74725_74725_1_RNF121-ANO1_RNF121_chr11_71671937_ENST00000361756_ANO1_chr11_69933858_ENST00000355303_length(transcript)=4981nt_BP=604nt
ACGTCTCGCTCCTTGGAGCCCAGACTGAGGGAGCGTCGCGAAAGTTGCCCGTTTTGGAACGCTCCCATTTGGCTCTCCAAAGGGAAGAAT
TGGTTAAATAGTTGCACTGAAAATAATGCGATTCAAATTTCTCATTTTCCAAGAACGCTCCCTTGCTGAAGCTTGCAAGGGCACGGTACT
CCCCTCTCCTTGACCCTGAAACGTGCAGCAAGTAGATAACCTCCTGATCCCTGACAGTCTCCGCCTGTGTTGATGCCCCGCCCCCTCTGC
TGGAGTCCGAGCCGCCGATTGGCTAGGAGCACTTGAGCAGCGGAAGCAGCTGGCTCGCGCGGGGACTGCGGTGAGGGGGCGAGCCGTGAA
GATGGCGGCAGTGGTGGAGGTGGAGGTTGGAGGTGGTGCTGCTGGGGAACGGGAGCTGGATGAGGTTGATATGTCAGATCTCTCTCCAGA
AGAGCAATGGAGGGTCGAGCACGCACGCATGCATGCCAAGCACCGTGGCCATGAAGCTATGCATGCTGAAATGGTCCTCATCCTCATCGC
AACCTTGGTGGTGGCCCAGCTGCTCCTGGTGCAGTGGAAGCAGAGGCACCCACGCTCCTACAATCTGCTGAACTCCTTATCTGTGGACCC
TGATGCCGAGTGCAAGTATGGCCTGTACTTCAGGGACGGCCGGCGCAAGGTGGACTACATCCTGGTGTACCATCACAAGAGGCCCTCGGG
CAACCGGACCCTGGTCAGGAGGGTGCAGCACAGCGACACCCCCTCTGGGGCTCGCAGCGTCAAGCAGGACCACCCCCTGCCGGGCAAGGG
GGCGTCGCTGGATGCAGGCTCGGGGGAGCCCCCGATGGACTACCACGAGGATGACAAGCGCTTCCGCAGGGAGGAGTACGAGGGCAACCT
CCTGGAGGCGGGCCTGGAGCTGGAGCGGGACGAGGACACTAAAATCCACGGAGTCGGGTTTGTGAAAATCCATGCCCCCTGGAACGTGCT
GTGCAGAGAGGCCGAGTTTCTGAAACTGAAGATGCCGACGAAGAAGATGTACCACATTAATGAGACCCGTGGCCTCCTGAAAAAAATCAA
CTCTGTGCTCCAGAAAATCACAGATCCCATCCAGCCCAAAGTGGCTGAGCACAGGCCCCAGACCATGAAGAGACTCTCCTATCCCTTCTC
CCGGGAGAAGCAGCATCTATTTGACTTGTCTGATAAGGATTCCTTTTTCGACAGCAAAACCCGGAGCACGATTGTCTATGAGATCTTGAA
GAGAACGACGTGTACAAAGGCCAAGTACAGCATGGGCATCACGAGCCTGCTGGCCAATGGTGTGTACGCGGCTGCATACCCACTGCACGA
TGGAGACTACAACGGTGAAAACGTCGAGTTCAACGACAGAAAACTCCTGTACGAAGAGTGGGCACGCTATGGAGTTTTCTATAAGTACCA
GCCCATCGACCTGGTCAGGAAGTATTTTGGGGAGAAGATCGGCCTGTACTTCGCCTGGCTGGGCGTGTACACCCAGATGCTCATCCCTGC
CTCCATCGTGGGAATCATTGTCTTCCTGTACGGATGCGCCACCATGGATGAAAACATCCCCAGCATGGAGATGTGTGACCAGAGACACAA
TATCACCATGTGCCCGCTTTGCGACAAGACCTGCAGCTACTGGAAGATGAGCTCAGCCTGCGCCACGGCCCGCGCCAGCCACCTCTTCGA
CAACCCCGCCACGGTCTTCTTCTCTGTCTTCATGGCCCTCTGGGCTGCCACCTTCATGGAGCACTGGAAGCGGAAACAGATGCGACTCAA
CTACCGCTGGGACCTCACGGGCTTTGAAGAGGAAGAGGAGGCTGTCAAGGATCATCCTAGAGCTGAATACGAAGCCAGAGTCTTGGAGAA
GTCTCTGAAGAAAGAGTCCAGAAACAAAGAGAAGCGCCGGCATATTCCAGAGGAGTCAACAAACAAATGGAAGCAGAGGGTTAAGACAGC
CATGGCGGGGGTGAAATTGACTGACAAAGTGAAGCTGACATGGAGAGATCGGTTCCCAGCCTACCTCACTAACTTGGTCTCCATCATCTT
CATGATTGCAGTGACGTTTGCCATCGTCCTCGGCGTCATCATCTACAGAATCTCCATGGCCGCCGCCTTGGCCATGAACTCCTCCCCCTC
CGTGCGGTCCAACATCCGGGTCACAGTCACAGCCACCGCAGTCATCATCAACCTAGTGGTCATCATCCTCCTGGACGAGGTGTATGGCTG
CATAGCCCGATGGCTCACCAAGATCGAGGTCCCAAAGACGGAGAAAAGCTTTGAGGAGAGGCTGATCTTCAAGGCTTTCCTGCTGAAGTT
TGTGAATTCCTACACCCCCATCTTTTACGTGGCGTTCTTCAAAGGCCGGTTTGTTGGACGCCCGGGCGACTACGTGTACATTTTCCGTTC
CTTCCGAATGGAAGAGTGTGCGCCAGGGGGCTGCCTGATGGAGCTATGCATCCAGCTCAGCATCATCATGCTGGGGAAACAGCTGATCCA
GAACAACCTGTTCGAGATCGGCATCCCGAAGATGAAGAAGCTCATCCGCTACCTGAAGCTGAAGCAGCAGAGCCCCCCTGACCACGAGGA
GTGTGTGAAGAGGAAACAGCGGTACGAGGTGGATTACAACCTGGAGCCCTTCGCGGGCCTCACCCCAGAGTACATGGAAATGATCATCCA
GTTTGGCTTCGTCACCCTGTTTGTCGCCTCCTTCCCCCTGGCCCCACTGTTTGCGCTGCTGAACAACATCATCGAGATCCGCCTGGACGC
CAAAAAGTTTGTCACTGAGCTCCGAAGGCCGGTAGCTGTCAGAGCCAAAGACATCGGAATCTGGTACAATATCCTCAGAGGCATTGGGAA
GCTTGCTGTCATCATCAATGCCTTCGTGATCTCCTTCACGTCTGACTTCATCCCGCGCCTGGTGTACCTCTACATGTACAGTAAGAACGG
GACCATGCACGGCTTCGTCAACCACACCCTCTCCTCCTTCAACGTCAGTGACTTCCAGAACGGCACGGCCCCCAATGACCCCCTGGACCT
GGGCTACGAGGTGCAGATCTGCAGGTATAAAGACTACCGAGAGCCGCCGTGGTCGGAAAACAAGTACGACATCTCCAAGGACTTCTGGGC
CGTCCTGGCAGCCCGGCTGGCGTTTGTCATCGTCTTCCAGAACCTGGTCATGTTCATGAGCGACTTTGTGGACTGGGTCATCCCGGACAT
CCCCAAGGACATCAGCCAGCAGATCCACAAGGAGAAGGTGCTCATGGTGGAGCTGTTCATGCGGGAGGAGCAAGACAAGCAGCAGCTGCT
GGAAACCTGGATGGAGAAGGAGCGGCAGAAGGACGAGCCGCCGTGCAACCACCACAACACCAAAGCCTGCCCAGACAGCCTCGGCAGCCC
AGCCCCCAGCCATGCCTACCACGGGGGCGTCCTGTAGCTATGCCAGCGGGGCTGGGCAGGCCAGCCGGGCATCCTGACCGATGGGCACCC
TCTCCCAGGGCAGGCGGCTTCCCGCTCCCACCAGGGCCCGGTGGGTCCTGGGTTTTCTGCAAACATGGAGGACCACTTTCTGATAGGACA
TTTTCCTTTCTTCTTTCTGTTTTCTTTCCCTTGTTTTTGCACAAAGCCATTATGCAGGGAATATTTTTTAATCTGTAGTATTCAAGATGA
ATCAAAATGATGGCTGGTAATACGGCAATAAGGTAGCAAAGGCAGGTGCTTTGCAGAAAGAATGCTTGGAAACTTGAGTCTCCCTAGAGG
TGAAAAGTGAGCAGAGGCCCGTAGAAACCCTCCTCTGAATCCTCCTAATTCCTTAAGATAGATGCAAAATGGTAAGCCGAGGCATCGCGC
AAAAGCTGGTGCGATGCTTCAGGGAAAATGGAAAACCCACGCAAGAATAATGATTGATTCCGGTTCCAAAAGGTGTCACCTACCTGTTTC
AGAAAAGTTAGACTTTCCATCGCCTTTTCCTTCCATCAGTTGAGTGGCTGAGAGAGAAGTGCCTCATCCCTGAGCCACACAGGGGGCGTG
GGAGCATCCCAGTTATCCCTGGAAAGCTAGAAGGGGACAGAGGTGTCCCTGATTAAGCAGGAAACAGCACCCTTGGCGTCCCCAGCAGGC
TCCCCACTGTCAGCCACACACCTGCCCCCATCACACCAAGCCGACCTCAGAGTTGTTCATCTTCCTTATGGGACAAAACCGGTTGACCAG
AAAATGGGCAGAGAGAGATGACCTCGGAAGCATTTCCACAGATGGTGTCAGGGTTTCAAGAAGTCTTAGGGCTTCCAGGGGTCCCCTGGA
AGCTTTAGAATATTTATGGGTTTTTTTTCAAATATCAATTATATGGTAGATTGAGGATTTTTTTTCTGTAGCTCAAAGGTGGAGGGAGTT
TATTAGTTAACCAAATATCGTTGAGAGGAATTTAAAATACTGTTACTACCAAAGATTTTTATTAATAAAGGCTTATATTTTGGTAACACT
TCTCTATATTTTTACTCACAGGAATGTCACTGTTGGACAATTATTTTAAAAGTGTATAAAACCAAGTCTCATAAATGATATGAGTGATCT
AAATTTGCAGCAATGATACTAAACAACTCTCTGAAATTTCTCAAGCACCAAGAGAAACATCATTTTAGCAAAGGCCAGGAGGAAAAATAG
AAATAAATTTGTCTTGAAGATCTCATTGATGTGATGTTACATTCCCTTTAATCTGCCAACTGTGGTCAAAGTTCATAGGTGTCGTACATT
TCCATTATTTGCTAAAATCATGCAATCTGATGCTTCTCTTTTCTCTTGTACAGTAAGTAGTTTGAAGTGGGTTTTGTATATAAATACTGT
ATTAAAAATTAGGCAATTACCAAAAATCCTTTTATGGAAACCATTTTTTTAAAAAGTGAATGTACACAAATCCACAGAGGACTGTGGCTG

>74725_74725_1_RNF121-ANO1_RNF121_chr11_71671937_ENST00000361756_ANO1_chr11_69933858_ENST00000355303_length(amino acids)=1045AA_BP=95
MARAGTAVRGRAVKMAAVVEVEVGGGAAGERELDEVDMSDLSPEEQWRVEHARMHAKHRGHEAMHAEMVLILIATLVVAQLLLVQWKQRH
PRSYNLLNSLSVDPDAECKYGLYFRDGRRKVDYILVYHHKRPSGNRTLVRRVQHSDTPSGARSVKQDHPLPGKGASLDAGSGEPPMDYHE
DDKRFRREEYEGNLLEAGLELERDEDTKIHGVGFVKIHAPWNVLCREAEFLKLKMPTKKMYHINETRGLLKKINSVLQKITDPIQPKVAE
HRPQTMKRLSYPFSREKQHLFDLSDKDSFFDSKTRSTIVYEILKRTTCTKAKYSMGITSLLANGVYAAAYPLHDGDYNGENVEFNDRKLL
YEEWARYGVFYKYQPIDLVRKYFGEKIGLYFAWLGVYTQMLIPASIVGIIVFLYGCATMDENIPSMEMCDQRHNITMCPLCDKTCSYWKM
SSACATARASHLFDNPATVFFSVFMALWAATFMEHWKRKQMRLNYRWDLTGFEEEEEAVKDHPRAEYEARVLEKSLKKESRNKEKRRHIP
EESTNKWKQRVKTAMAGVKLTDKVKLTWRDRFPAYLTNLVSIIFMIAVTFAIVLGVIIYRISMAAALAMNSSPSVRSNIRVTVTATAVII
NLVVIILLDEVYGCIARWLTKIEVPKTEKSFEERLIFKAFLLKFVNSYTPIFYVAFFKGRFVGRPGDYVYIFRSFRMEECAPGGCLMELC
IQLSIIMLGKQLIQNNLFEIGIPKMKKLIRYLKLKQQSPPDHEECVKRKQRYEVDYNLEPFAGLTPEYMEMIIQFGFVTLFVASFPLAPL
FALLNNIIEIRLDAKKFVTELRRPVAVRAKDIGIWYNILRGIGKLAVIINAFVISFTSDFIPRLVYLYMYSKNGTMHGFVNHTLSSFNVS
DFQNGTAPNDPLDLGYEVQICRYKDYREPPWSENKYDISKDFWAVLAARLAFVIVFQNLVMFMSDFVDWVIPDIPKDISQQIHKEKVLMV

--------------------------------------------------------------
>74725_74725_2_RNF121-ANO1_RNF121_chr11_71671937_ENST00000393713_ANO1_chr11_69933858_ENST00000355303_length(transcript)=4610nt_BP=233nt
GACTGCGGTGAGGGGGCGAGCCGTGAAGATGGCGGCAGTGGTGGAGGTGGAGGTTGGAGGTGGTGCTGCTGGGGAACGGGAGCTGGATGA
GGGTCGAGCACGCACGCATGCATGCCAAGCACCGTGGCCATGAAGCTATGCATGCTGAAATGGTCCTCATCCTCATCGCAACCTTGGTGG
TGGCCCAGCTGCTCCTGGTGCAGTGGAAGCAGAGGCACCCACGCTCCTACAATCTGCTGAACTCCTTATCTGTGGACCCTGATGCCGAGT
GCAAGTATGGCCTGTACTTCAGGGACGGCCGGCGCAAGGTGGACTACATCCTGGTGTACCATCACAAGAGGCCCTCGGGCAACCGGACCC
TGGTCAGGAGGGTGCAGCACAGCGACACCCCCTCTGGGGCTCGCAGCGTCAAGCAGGACCACCCCCTGCCGGGCAAGGGGGCGTCGCTGG
ATGCAGGCTCGGGGGAGCCCCCGATGGACTACCACGAGGATGACAAGCGCTTCCGCAGGGAGGAGTACGAGGGCAACCTCCTGGAGGCGG
GCCTGGAGCTGGAGCGGGACGAGGACACTAAAATCCACGGAGTCGGGTTTGTGAAAATCCATGCCCCCTGGAACGTGCTGTGCAGAGAGG
CCGAGTTTCTGAAACTGAAGATGCCGACGAAGAAGATGTACCACATTAATGAGACCCGTGGCCTCCTGAAAAAAATCAACTCTGTGCTCC
AGAAAATCACAGATCCCATCCAGCCCAAAGTGGCTGAGCACAGGCCCCAGACCATGAAGAGACTCTCCTATCCCTTCTCCCGGGAGAAGC
AGCATCTATTTGACTTGTCTGATAAGGATTCCTTTTTCGACAGCAAAACCCGGAGCACGATTGTCTATGAGATCTTGAAGAGAACGACGT
GTACAAAGGCCAAGTACAGCATGGGCATCACGAGCCTGCTGGCCAATGGTGTGTACGCGGCTGCATACCCACTGCACGATGGAGACTACA
ACGGTGAAAACGTCGAGTTCAACGACAGAAAACTCCTGTACGAAGAGTGGGCACGCTATGGAGTTTTCTATAAGTACCAGCCCATCGACC
TGGTCAGGAAGTATTTTGGGGAGAAGATCGGCCTGTACTTCGCCTGGCTGGGCGTGTACACCCAGATGCTCATCCCTGCCTCCATCGTGG
GAATCATTGTCTTCCTGTACGGATGCGCCACCATGGATGAAAACATCCCCAGCATGGAGATGTGTGACCAGAGACACAATATCACCATGT
GCCCGCTTTGCGACAAGACCTGCAGCTACTGGAAGATGAGCTCAGCCTGCGCCACGGCCCGCGCCAGCCACCTCTTCGACAACCCCGCCA
CGGTCTTCTTCTCTGTCTTCATGGCCCTCTGGGCTGCCACCTTCATGGAGCACTGGAAGCGGAAACAGATGCGACTCAACTACCGCTGGG
ACCTCACGGGCTTTGAAGAGGAAGAGGAGGCTGTCAAGGATCATCCTAGAGCTGAATACGAAGCCAGAGTCTTGGAGAAGTCTCTGAAGA
AAGAGTCCAGAAACAAAGAGAAGCGCCGGCATATTCCAGAGGAGTCAACAAACAAATGGAAGCAGAGGGTTAAGACAGCCATGGCGGGGG
TGAAATTGACTGACAAAGTGAAGCTGACATGGAGAGATCGGTTCCCAGCCTACCTCACTAACTTGGTCTCCATCATCTTCATGATTGCAG
TGACGTTTGCCATCGTCCTCGGCGTCATCATCTACAGAATCTCCATGGCCGCCGCCTTGGCCATGAACTCCTCCCCCTCCGTGCGGTCCA
ACATCCGGGTCACAGTCACAGCCACCGCAGTCATCATCAACCTAGTGGTCATCATCCTCCTGGACGAGGTGTATGGCTGCATAGCCCGAT
GGCTCACCAAGATCGAGGTCCCAAAGACGGAGAAAAGCTTTGAGGAGAGGCTGATCTTCAAGGCTTTCCTGCTGAAGTTTGTGAATTCCT
ACACCCCCATCTTTTACGTGGCGTTCTTCAAAGGCCGGTTTGTTGGACGCCCGGGCGACTACGTGTACATTTTCCGTTCCTTCCGAATGG
AAGAGTGTGCGCCAGGGGGCTGCCTGATGGAGCTATGCATCCAGCTCAGCATCATCATGCTGGGGAAACAGCTGATCCAGAACAACCTGT
TCGAGATCGGCATCCCGAAGATGAAGAAGCTCATCCGCTACCTGAAGCTGAAGCAGCAGAGCCCCCCTGACCACGAGGAGTGTGTGAAGA
GGAAACAGCGGTACGAGGTGGATTACAACCTGGAGCCCTTCGCGGGCCTCACCCCAGAGTACATGGAAATGATCATCCAGTTTGGCTTCG
TCACCCTGTTTGTCGCCTCCTTCCCCCTGGCCCCACTGTTTGCGCTGCTGAACAACATCATCGAGATCCGCCTGGACGCCAAAAAGTTTG
TCACTGAGCTCCGAAGGCCGGTAGCTGTCAGAGCCAAAGACATCGGAATCTGGTACAATATCCTCAGAGGCATTGGGAAGCTTGCTGTCA
TCATCAATGCCTTCGTGATCTCCTTCACGTCTGACTTCATCCCGCGCCTGGTGTACCTCTACATGTACAGTAAGAACGGGACCATGCACG
GCTTCGTCAACCACACCCTCTCCTCCTTCAACGTCAGTGACTTCCAGAACGGCACGGCCCCCAATGACCCCCTGGACCTGGGCTACGAGG
TGCAGATCTGCAGGTATAAAGACTACCGAGAGCCGCCGTGGTCGGAAAACAAGTACGACATCTCCAAGGACTTCTGGGCCGTCCTGGCAG
CCCGGCTGGCGTTTGTCATCGTCTTCCAGAACCTGGTCATGTTCATGAGCGACTTTGTGGACTGGGTCATCCCGGACATCCCCAAGGACA
TCAGCCAGCAGATCCACAAGGAGAAGGTGCTCATGGTGGAGCTGTTCATGCGGGAGGAGCAAGACAAGCAGCAGCTGCTGGAAACCTGGA
TGGAGAAGGAGCGGCAGAAGGACGAGCCGCCGTGCAACCACCACAACACCAAAGCCTGCCCAGACAGCCTCGGCAGCCCAGCCCCCAGCC
ATGCCTACCACGGGGGCGTCCTGTAGCTATGCCAGCGGGGCTGGGCAGGCCAGCCGGGCATCCTGACCGATGGGCACCCTCTCCCAGGGC
AGGCGGCTTCCCGCTCCCACCAGGGCCCGGTGGGTCCTGGGTTTTCTGCAAACATGGAGGACCACTTTCTGATAGGACATTTTCCTTTCT
TCTTTCTGTTTTCTTTCCCTTGTTTTTGCACAAAGCCATTATGCAGGGAATATTTTTTAATCTGTAGTATTCAAGATGAATCAAAATGAT
GGCTGGTAATACGGCAATAAGGTAGCAAAGGCAGGTGCTTTGCAGAAAGAATGCTTGGAAACTTGAGTCTCCCTAGAGGTGAAAAGTGAG
CAGAGGCCCGTAGAAACCCTCCTCTGAATCCTCCTAATTCCTTAAGATAGATGCAAAATGGTAAGCCGAGGCATCGCGCAAAAGCTGGTG
CGATGCTTCAGGGAAAATGGAAAACCCACGCAAGAATAATGATTGATTCCGGTTCCAAAAGGTGTCACCTACCTGTTTCAGAAAAGTTAG
ACTTTCCATCGCCTTTTCCTTCCATCAGTTGAGTGGCTGAGAGAGAAGTGCCTCATCCCTGAGCCACACAGGGGGCGTGGGAGCATCCCA
GTTATCCCTGGAAAGCTAGAAGGGGACAGAGGTGTCCCTGATTAAGCAGGAAACAGCACCCTTGGCGTCCCCAGCAGGCTCCCCACTGTC
AGCCACACACCTGCCCCCATCACACCAAGCCGACCTCAGAGTTGTTCATCTTCCTTATGGGACAAAACCGGTTGACCAGAAAATGGGCAG
AGAGAGATGACCTCGGAAGCATTTCCACAGATGGTGTCAGGGTTTCAAGAAGTCTTAGGGCTTCCAGGGGTCCCCTGGAAGCTTTAGAAT
ATTTATGGGTTTTTTTTCAAATATCAATTATATGGTAGATTGAGGATTTTTTTTCTGTAGCTCAAAGGTGGAGGGAGTTTATTAGTTAAC
CAAATATCGTTGAGAGGAATTTAAAATACTGTTACTACCAAAGATTTTTATTAATAAAGGCTTATATTTTGGTAACACTTCTCTATATTT
TTACTCACAGGAATGTCACTGTTGGACAATTATTTTAAAAGTGTATAAAACCAAGTCTCATAAATGATATGAGTGATCTAAATTTGCAGC
AATGATACTAAACAACTCTCTGAAATTTCTCAAGCACCAAGAGAAACATCATTTTAGCAAAGGCCAGGAGGAAAAATAGAAATAAATTTG
TCTTGAAGATCTCATTGATGTGATGTTACATTCCCTTTAATCTGCCAACTGTGGTCAAAGTTCATAGGTGTCGTACATTTCCATTATTTG
CTAAAATCATGCAATCTGATGCTTCTCTTTTCTCTTGTACAGTAAGTAGTTTGAAGTGGGTTTTGTATATAAATACTGTATTAAAAATTA
GGCAATTACCAAAAATCCTTTTATGGAAACCATTTTTTTAAAAAGTGAATGTACACAAATCCACAGAGGACTGTGGCTGGACATTCATCT

>74725_74725_2_RNF121-ANO1_RNF121_chr11_71671937_ENST00000393713_ANO1_chr11_69933858_ENST00000355303_length(amino acids)=1010AA_BP=60
MEVVLLGNGSWMRVEHARMHAKHRGHEAMHAEMVLILIATLVVAQLLLVQWKQRHPRSYNLLNSLSVDPDAECKYGLYFRDGRRKVDYIL
VYHHKRPSGNRTLVRRVQHSDTPSGARSVKQDHPLPGKGASLDAGSGEPPMDYHEDDKRFRREEYEGNLLEAGLELERDEDTKIHGVGFV
KIHAPWNVLCREAEFLKLKMPTKKMYHINETRGLLKKINSVLQKITDPIQPKVAEHRPQTMKRLSYPFSREKQHLFDLSDKDSFFDSKTR
STIVYEILKRTTCTKAKYSMGITSLLANGVYAAAYPLHDGDYNGENVEFNDRKLLYEEWARYGVFYKYQPIDLVRKYFGEKIGLYFAWLG
VYTQMLIPASIVGIIVFLYGCATMDENIPSMEMCDQRHNITMCPLCDKTCSYWKMSSACATARASHLFDNPATVFFSVFMALWAATFMEH
WKRKQMRLNYRWDLTGFEEEEEAVKDHPRAEYEARVLEKSLKKESRNKEKRRHIPEESTNKWKQRVKTAMAGVKLTDKVKLTWRDRFPAY
LTNLVSIIFMIAVTFAIVLGVIIYRISMAAALAMNSSPSVRSNIRVTVTATAVIINLVVIILLDEVYGCIARWLTKIEVPKTEKSFEERL
IFKAFLLKFVNSYTPIFYVAFFKGRFVGRPGDYVYIFRSFRMEECAPGGCLMELCIQLSIIMLGKQLIQNNLFEIGIPKMKKLIRYLKLK
QQSPPDHEECVKRKQRYEVDYNLEPFAGLTPEYMEMIIQFGFVTLFVASFPLAPLFALLNNIIEIRLDAKKFVTELRRPVAVRAKDIGIW
YNILRGIGKLAVIINAFVISFTSDFIPRLVYLYMYSKNGTMHGFVNHTLSSFNVSDFQNGTAPNDPLDLGYEVQICRYKDYREPPWSENK
YDISKDFWAVLAARLAFVIVFQNLVMFMSDFVDWVIPDIPKDISQQIHKEKVLMVELFMREEQDKQQLLETWMEKERQKDEPPCNHHNTK

--------------------------------------------------------------
>74725_74725_3_RNF121-ANO1_RNF121_chr11_71671937_ENST00000530137_ANO1_chr11_69933858_ENST00000355303_length(transcript)=4562nt_BP=185nt
GGAGGTTGGAGGTGGTGCTGCTGGGGAACGGGAGCTGGATGAGGGTCGAGCACGCACGCATGCATGCCAAGCACCGTGGCCATGAAGCTA
TGCATGCTGAAATGGTCCTCATCCTCATCGCAACCTTGGTGGTGGCCCAGCTGCTCCTGGTGCAGTGGAAGCAGAGGCACCCACGCTCCT
ACAATCTGCTGAACTCCTTATCTGTGGACCCTGATGCCGAGTGCAAGTATGGCCTGTACTTCAGGGACGGCCGGCGCAAGGTGGACTACA
TCCTGGTGTACCATCACAAGAGGCCCTCGGGCAACCGGACCCTGGTCAGGAGGGTGCAGCACAGCGACACCCCCTCTGGGGCTCGCAGCG
TCAAGCAGGACCACCCCCTGCCGGGCAAGGGGGCGTCGCTGGATGCAGGCTCGGGGGAGCCCCCGATGGACTACCACGAGGATGACAAGC
GCTTCCGCAGGGAGGAGTACGAGGGCAACCTCCTGGAGGCGGGCCTGGAGCTGGAGCGGGACGAGGACACTAAAATCCACGGAGTCGGGT
TTGTGAAAATCCATGCCCCCTGGAACGTGCTGTGCAGAGAGGCCGAGTTTCTGAAACTGAAGATGCCGACGAAGAAGATGTACCACATTA
ATGAGACCCGTGGCCTCCTGAAAAAAATCAACTCTGTGCTCCAGAAAATCACAGATCCCATCCAGCCCAAAGTGGCTGAGCACAGGCCCC
AGACCATGAAGAGACTCTCCTATCCCTTCTCCCGGGAGAAGCAGCATCTATTTGACTTGTCTGATAAGGATTCCTTTTTCGACAGCAAAA
CCCGGAGCACGATTGTCTATGAGATCTTGAAGAGAACGACGTGTACAAAGGCCAAGTACAGCATGGGCATCACGAGCCTGCTGGCCAATG
GTGTGTACGCGGCTGCATACCCACTGCACGATGGAGACTACAACGGTGAAAACGTCGAGTTCAACGACAGAAAACTCCTGTACGAAGAGT
GGGCACGCTATGGAGTTTTCTATAAGTACCAGCCCATCGACCTGGTCAGGAAGTATTTTGGGGAGAAGATCGGCCTGTACTTCGCCTGGC
TGGGCGTGTACACCCAGATGCTCATCCCTGCCTCCATCGTGGGAATCATTGTCTTCCTGTACGGATGCGCCACCATGGATGAAAACATCC
CCAGCATGGAGATGTGTGACCAGAGACACAATATCACCATGTGCCCGCTTTGCGACAAGACCTGCAGCTACTGGAAGATGAGCTCAGCCT
GCGCCACGGCCCGCGCCAGCCACCTCTTCGACAACCCCGCCACGGTCTTCTTCTCTGTCTTCATGGCCCTCTGGGCTGCCACCTTCATGG
AGCACTGGAAGCGGAAACAGATGCGACTCAACTACCGCTGGGACCTCACGGGCTTTGAAGAGGAAGAGGAGGCTGTCAAGGATCATCCTA
GAGCTGAATACGAAGCCAGAGTCTTGGAGAAGTCTCTGAAGAAAGAGTCCAGAAACAAAGAGAAGCGCCGGCATATTCCAGAGGAGTCAA
CAAACAAATGGAAGCAGAGGGTTAAGACAGCCATGGCGGGGGTGAAATTGACTGACAAAGTGAAGCTGACATGGAGAGATCGGTTCCCAG
CCTACCTCACTAACTTGGTCTCCATCATCTTCATGATTGCAGTGACGTTTGCCATCGTCCTCGGCGTCATCATCTACAGAATCTCCATGG
CCGCCGCCTTGGCCATGAACTCCTCCCCCTCCGTGCGGTCCAACATCCGGGTCACAGTCACAGCCACCGCAGTCATCATCAACCTAGTGG
TCATCATCCTCCTGGACGAGGTGTATGGCTGCATAGCCCGATGGCTCACCAAGATCGAGGTCCCAAAGACGGAGAAAAGCTTTGAGGAGA
GGCTGATCTTCAAGGCTTTCCTGCTGAAGTTTGTGAATTCCTACACCCCCATCTTTTACGTGGCGTTCTTCAAAGGCCGGTTTGTTGGAC
GCCCGGGCGACTACGTGTACATTTTCCGTTCCTTCCGAATGGAAGAGTGTGCGCCAGGGGGCTGCCTGATGGAGCTATGCATCCAGCTCA
GCATCATCATGCTGGGGAAACAGCTGATCCAGAACAACCTGTTCGAGATCGGCATCCCGAAGATGAAGAAGCTCATCCGCTACCTGAAGC
TGAAGCAGCAGAGCCCCCCTGACCACGAGGAGTGTGTGAAGAGGAAACAGCGGTACGAGGTGGATTACAACCTGGAGCCCTTCGCGGGCC
TCACCCCAGAGTACATGGAAATGATCATCCAGTTTGGCTTCGTCACCCTGTTTGTCGCCTCCTTCCCCCTGGCCCCACTGTTTGCGCTGC
TGAACAACATCATCGAGATCCGCCTGGACGCCAAAAAGTTTGTCACTGAGCTCCGAAGGCCGGTAGCTGTCAGAGCCAAAGACATCGGAA
TCTGGTACAATATCCTCAGAGGCATTGGGAAGCTTGCTGTCATCATCAATGCCTTCGTGATCTCCTTCACGTCTGACTTCATCCCGCGCC
TGGTGTACCTCTACATGTACAGTAAGAACGGGACCATGCACGGCTTCGTCAACCACACCCTCTCCTCCTTCAACGTCAGTGACTTCCAGA
ACGGCACGGCCCCCAATGACCCCCTGGACCTGGGCTACGAGGTGCAGATCTGCAGGTATAAAGACTACCGAGAGCCGCCGTGGTCGGAAA
ACAAGTACGACATCTCCAAGGACTTCTGGGCCGTCCTGGCAGCCCGGCTGGCGTTTGTCATCGTCTTCCAGAACCTGGTCATGTTCATGA
GCGACTTTGTGGACTGGGTCATCCCGGACATCCCCAAGGACATCAGCCAGCAGATCCACAAGGAGAAGGTGCTCATGGTGGAGCTGTTCA
TGCGGGAGGAGCAAGACAAGCAGCAGCTGCTGGAAACCTGGATGGAGAAGGAGCGGCAGAAGGACGAGCCGCCGTGCAACCACCACAACA
CCAAAGCCTGCCCAGACAGCCTCGGCAGCCCAGCCCCCAGCCATGCCTACCACGGGGGCGTCCTGTAGCTATGCCAGCGGGGCTGGGCAG
GCCAGCCGGGCATCCTGACCGATGGGCACCCTCTCCCAGGGCAGGCGGCTTCCCGCTCCCACCAGGGCCCGGTGGGTCCTGGGTTTTCTG
CAAACATGGAGGACCACTTTCTGATAGGACATTTTCCTTTCTTCTTTCTGTTTTCTTTCCCTTGTTTTTGCACAAAGCCATTATGCAGGG
AATATTTTTTAATCTGTAGTATTCAAGATGAATCAAAATGATGGCTGGTAATACGGCAATAAGGTAGCAAAGGCAGGTGCTTTGCAGAAA
GAATGCTTGGAAACTTGAGTCTCCCTAGAGGTGAAAAGTGAGCAGAGGCCCGTAGAAACCCTCCTCTGAATCCTCCTAATTCCTTAAGAT
AGATGCAAAATGGTAAGCCGAGGCATCGCGCAAAAGCTGGTGCGATGCTTCAGGGAAAATGGAAAACCCACGCAAGAATAATGATTGATT
CCGGTTCCAAAAGGTGTCACCTACCTGTTTCAGAAAAGTTAGACTTTCCATCGCCTTTTCCTTCCATCAGTTGAGTGGCTGAGAGAGAAG
TGCCTCATCCCTGAGCCACACAGGGGGCGTGGGAGCATCCCAGTTATCCCTGGAAAGCTAGAAGGGGACAGAGGTGTCCCTGATTAAGCA
GGAAACAGCACCCTTGGCGTCCCCAGCAGGCTCCCCACTGTCAGCCACACACCTGCCCCCATCACACCAAGCCGACCTCAGAGTTGTTCA
TCTTCCTTATGGGACAAAACCGGTTGACCAGAAAATGGGCAGAGAGAGATGACCTCGGAAGCATTTCCACAGATGGTGTCAGGGTTTCAA
GAAGTCTTAGGGCTTCCAGGGGTCCCCTGGAAGCTTTAGAATATTTATGGGTTTTTTTTCAAATATCAATTATATGGTAGATTGAGGATT
TTTTTTCTGTAGCTCAAAGGTGGAGGGAGTTTATTAGTTAACCAAATATCGTTGAGAGGAATTTAAAATACTGTTACTACCAAAGATTTT
TATTAATAAAGGCTTATATTTTGGTAACACTTCTCTATATTTTTACTCACAGGAATGTCACTGTTGGACAATTATTTTAAAAGTGTATAA
AACCAAGTCTCATAAATGATATGAGTGATCTAAATTTGCAGCAATGATACTAAACAACTCTCTGAAATTTCTCAAGCACCAAGAGAAACA
TCATTTTAGCAAAGGCCAGGAGGAAAAATAGAAATAAATTTGTCTTGAAGATCTCATTGATGTGATGTTACATTCCCTTTAATCTGCCAA
CTGTGGTCAAAGTTCATAGGTGTCGTACATTTCCATTATTTGCTAAAATCATGCAATCTGATGCTTCTCTTTTCTCTTGTACAGTAAGTA
GTTTGAAGTGGGTTTTGTATATAAATACTGTATTAAAAATTAGGCAATTACCAAAAATCCTTTTATGGAAACCATTTTTTTAAAAAGTGA

>74725_74725_3_RNF121-ANO1_RNF121_chr11_71671937_ENST00000530137_ANO1_chr11_69933858_ENST00000355303_length(amino acids)=1010AA_BP=60
MEVVLLGNGSWMRVEHARMHAKHRGHEAMHAEMVLILIATLVVAQLLLVQWKQRHPRSYNLLNSLSVDPDAECKYGLYFRDGRRKVDYIL
VYHHKRPSGNRTLVRRVQHSDTPSGARSVKQDHPLPGKGASLDAGSGEPPMDYHEDDKRFRREEYEGNLLEAGLELERDEDTKIHGVGFV
KIHAPWNVLCREAEFLKLKMPTKKMYHINETRGLLKKINSVLQKITDPIQPKVAEHRPQTMKRLSYPFSREKQHLFDLSDKDSFFDSKTR
STIVYEILKRTTCTKAKYSMGITSLLANGVYAAAYPLHDGDYNGENVEFNDRKLLYEEWARYGVFYKYQPIDLVRKYFGEKIGLYFAWLG
VYTQMLIPASIVGIIVFLYGCATMDENIPSMEMCDQRHNITMCPLCDKTCSYWKMSSACATARASHLFDNPATVFFSVFMALWAATFMEH
WKRKQMRLNYRWDLTGFEEEEEAVKDHPRAEYEARVLEKSLKKESRNKEKRRHIPEESTNKWKQRVKTAMAGVKLTDKVKLTWRDRFPAY
LTNLVSIIFMIAVTFAIVLGVIIYRISMAAALAMNSSPSVRSNIRVTVTATAVIINLVVIILLDEVYGCIARWLTKIEVPKTEKSFEERL
IFKAFLLKFVNSYTPIFYVAFFKGRFVGRPGDYVYIFRSFRMEECAPGGCLMELCIQLSIIMLGKQLIQNNLFEIGIPKMKKLIRYLKLK
QQSPPDHEECVKRKQRYEVDYNLEPFAGLTPEYMEMIIQFGFVTLFVASFPLAPLFALLNNIIEIRLDAKKFVTELRRPVAVRAKDIGIW
YNILRGIGKLAVIINAFVISFTSDFIPRLVYLYMYSKNGTMHGFVNHTLSSFNVSDFQNGTAPNDPLDLGYEVQICRYKDYREPPWSENK
YDISKDFWAVLAARLAFVIVFQNLVMFMSDFVDWVIPDIPKDISQQIHKEKVLMVELFMREEQDKQQLLETWMEKERQKDEPPCNHHNTK

--------------------------------------------------------------
>74725_74725_4_RNF121-ANO1_RNF121_chr11_71671937_ENST00000533380_ANO1_chr11_69933858_ENST00000355303_length(transcript)=4612nt_BP=235nt
GGGACTGCGGTGAGGGGGCGAGCCGTGAAGATGGCGGCAGTGGTGGAGGTGGAGGTTGGAGGTGGTGCTGCTGGGGAACGGGAGCTGGAT
GAGGGTCGAGCACGCACGCATGCATGCCAAGCACCGTGGCCATGAAGCTATGCATGCTGAAATGGTCCTCATCCTCATCGCAACCTTGGT
GGTGGCCCAGCTGCTCCTGGTGCAGTGGAAGCAGAGGCACCCACGCTCCTACAATCTGCTGAACTCCTTATCTGTGGACCCTGATGCCGA
GTGCAAGTATGGCCTGTACTTCAGGGACGGCCGGCGCAAGGTGGACTACATCCTGGTGTACCATCACAAGAGGCCCTCGGGCAACCGGAC
CCTGGTCAGGAGGGTGCAGCACAGCGACACCCCCTCTGGGGCTCGCAGCGTCAAGCAGGACCACCCCCTGCCGGGCAAGGGGGCGTCGCT
GGATGCAGGCTCGGGGGAGCCCCCGATGGACTACCACGAGGATGACAAGCGCTTCCGCAGGGAGGAGTACGAGGGCAACCTCCTGGAGGC
GGGCCTGGAGCTGGAGCGGGACGAGGACACTAAAATCCACGGAGTCGGGTTTGTGAAAATCCATGCCCCCTGGAACGTGCTGTGCAGAGA
GGCCGAGTTTCTGAAACTGAAGATGCCGACGAAGAAGATGTACCACATTAATGAGACCCGTGGCCTCCTGAAAAAAATCAACTCTGTGCT
CCAGAAAATCACAGATCCCATCCAGCCCAAAGTGGCTGAGCACAGGCCCCAGACCATGAAGAGACTCTCCTATCCCTTCTCCCGGGAGAA
GCAGCATCTATTTGACTTGTCTGATAAGGATTCCTTTTTCGACAGCAAAACCCGGAGCACGATTGTCTATGAGATCTTGAAGAGAACGAC
GTGTACAAAGGCCAAGTACAGCATGGGCATCACGAGCCTGCTGGCCAATGGTGTGTACGCGGCTGCATACCCACTGCACGATGGAGACTA
CAACGGTGAAAACGTCGAGTTCAACGACAGAAAACTCCTGTACGAAGAGTGGGCACGCTATGGAGTTTTCTATAAGTACCAGCCCATCGA
CCTGGTCAGGAAGTATTTTGGGGAGAAGATCGGCCTGTACTTCGCCTGGCTGGGCGTGTACACCCAGATGCTCATCCCTGCCTCCATCGT
GGGAATCATTGTCTTCCTGTACGGATGCGCCACCATGGATGAAAACATCCCCAGCATGGAGATGTGTGACCAGAGACACAATATCACCAT
GTGCCCGCTTTGCGACAAGACCTGCAGCTACTGGAAGATGAGCTCAGCCTGCGCCACGGCCCGCGCCAGCCACCTCTTCGACAACCCCGC
CACGGTCTTCTTCTCTGTCTTCATGGCCCTCTGGGCTGCCACCTTCATGGAGCACTGGAAGCGGAAACAGATGCGACTCAACTACCGCTG
GGACCTCACGGGCTTTGAAGAGGAAGAGGAGGCTGTCAAGGATCATCCTAGAGCTGAATACGAAGCCAGAGTCTTGGAGAAGTCTCTGAA
GAAAGAGTCCAGAAACAAAGAGAAGCGCCGGCATATTCCAGAGGAGTCAACAAACAAATGGAAGCAGAGGGTTAAGACAGCCATGGCGGG
GGTGAAATTGACTGACAAAGTGAAGCTGACATGGAGAGATCGGTTCCCAGCCTACCTCACTAACTTGGTCTCCATCATCTTCATGATTGC
AGTGACGTTTGCCATCGTCCTCGGCGTCATCATCTACAGAATCTCCATGGCCGCCGCCTTGGCCATGAACTCCTCCCCCTCCGTGCGGTC
CAACATCCGGGTCACAGTCACAGCCACCGCAGTCATCATCAACCTAGTGGTCATCATCCTCCTGGACGAGGTGTATGGCTGCATAGCCCG
ATGGCTCACCAAGATCGAGGTCCCAAAGACGGAGAAAAGCTTTGAGGAGAGGCTGATCTTCAAGGCTTTCCTGCTGAAGTTTGTGAATTC
CTACACCCCCATCTTTTACGTGGCGTTCTTCAAAGGCCGGTTTGTTGGACGCCCGGGCGACTACGTGTACATTTTCCGTTCCTTCCGAAT
GGAAGAGTGTGCGCCAGGGGGCTGCCTGATGGAGCTATGCATCCAGCTCAGCATCATCATGCTGGGGAAACAGCTGATCCAGAACAACCT
GTTCGAGATCGGCATCCCGAAGATGAAGAAGCTCATCCGCTACCTGAAGCTGAAGCAGCAGAGCCCCCCTGACCACGAGGAGTGTGTGAA
GAGGAAACAGCGGTACGAGGTGGATTACAACCTGGAGCCCTTCGCGGGCCTCACCCCAGAGTACATGGAAATGATCATCCAGTTTGGCTT
CGTCACCCTGTTTGTCGCCTCCTTCCCCCTGGCCCCACTGTTTGCGCTGCTGAACAACATCATCGAGATCCGCCTGGACGCCAAAAAGTT
TGTCACTGAGCTCCGAAGGCCGGTAGCTGTCAGAGCCAAAGACATCGGAATCTGGTACAATATCCTCAGAGGCATTGGGAAGCTTGCTGT
CATCATCAATGCCTTCGTGATCTCCTTCACGTCTGACTTCATCCCGCGCCTGGTGTACCTCTACATGTACAGTAAGAACGGGACCATGCA
CGGCTTCGTCAACCACACCCTCTCCTCCTTCAACGTCAGTGACTTCCAGAACGGCACGGCCCCCAATGACCCCCTGGACCTGGGCTACGA
GGTGCAGATCTGCAGGTATAAAGACTACCGAGAGCCGCCGTGGTCGGAAAACAAGTACGACATCTCCAAGGACTTCTGGGCCGTCCTGGC
AGCCCGGCTGGCGTTTGTCATCGTCTTCCAGAACCTGGTCATGTTCATGAGCGACTTTGTGGACTGGGTCATCCCGGACATCCCCAAGGA
CATCAGCCAGCAGATCCACAAGGAGAAGGTGCTCATGGTGGAGCTGTTCATGCGGGAGGAGCAAGACAAGCAGCAGCTGCTGGAAACCTG
GATGGAGAAGGAGCGGCAGAAGGACGAGCCGCCGTGCAACCACCACAACACCAAAGCCTGCCCAGACAGCCTCGGCAGCCCAGCCCCCAG
CCATGCCTACCACGGGGGCGTCCTGTAGCTATGCCAGCGGGGCTGGGCAGGCCAGCCGGGCATCCTGACCGATGGGCACCCTCTCCCAGG
GCAGGCGGCTTCCCGCTCCCACCAGGGCCCGGTGGGTCCTGGGTTTTCTGCAAACATGGAGGACCACTTTCTGATAGGACATTTTCCTTT
CTTCTTTCTGTTTTCTTTCCCTTGTTTTTGCACAAAGCCATTATGCAGGGAATATTTTTTAATCTGTAGTATTCAAGATGAATCAAAATG
ATGGCTGGTAATACGGCAATAAGGTAGCAAAGGCAGGTGCTTTGCAGAAAGAATGCTTGGAAACTTGAGTCTCCCTAGAGGTGAAAAGTG
AGCAGAGGCCCGTAGAAACCCTCCTCTGAATCCTCCTAATTCCTTAAGATAGATGCAAAATGGTAAGCCGAGGCATCGCGCAAAAGCTGG
TGCGATGCTTCAGGGAAAATGGAAAACCCACGCAAGAATAATGATTGATTCCGGTTCCAAAAGGTGTCACCTACCTGTTTCAGAAAAGTT
AGACTTTCCATCGCCTTTTCCTTCCATCAGTTGAGTGGCTGAGAGAGAAGTGCCTCATCCCTGAGCCACACAGGGGGCGTGGGAGCATCC
CAGTTATCCCTGGAAAGCTAGAAGGGGACAGAGGTGTCCCTGATTAAGCAGGAAACAGCACCCTTGGCGTCCCCAGCAGGCTCCCCACTG
TCAGCCACACACCTGCCCCCATCACACCAAGCCGACCTCAGAGTTGTTCATCTTCCTTATGGGACAAAACCGGTTGACCAGAAAATGGGC
AGAGAGAGATGACCTCGGAAGCATTTCCACAGATGGTGTCAGGGTTTCAAGAAGTCTTAGGGCTTCCAGGGGTCCCCTGGAAGCTTTAGA
ATATTTATGGGTTTTTTTTCAAATATCAATTATATGGTAGATTGAGGATTTTTTTTCTGTAGCTCAAAGGTGGAGGGAGTTTATTAGTTA
ACCAAATATCGTTGAGAGGAATTTAAAATACTGTTACTACCAAAGATTTTTATTAATAAAGGCTTATATTTTGGTAACACTTCTCTATAT
TTTTACTCACAGGAATGTCACTGTTGGACAATTATTTTAAAAGTGTATAAAACCAAGTCTCATAAATGATATGAGTGATCTAAATTTGCA
GCAATGATACTAAACAACTCTCTGAAATTTCTCAAGCACCAAGAGAAACATCATTTTAGCAAAGGCCAGGAGGAAAAATAGAAATAAATT
TGTCTTGAAGATCTCATTGATGTGATGTTACATTCCCTTTAATCTGCCAACTGTGGTCAAAGTTCATAGGTGTCGTACATTTCCATTATT
TGCTAAAATCATGCAATCTGATGCTTCTCTTTTCTCTTGTACAGTAAGTAGTTTGAAGTGGGTTTTGTATATAAATACTGTATTAAAAAT
TAGGCAATTACCAAAAATCCTTTTATGGAAACCATTTTTTTAAAAAGTGAATGTACACAAATCCACAGAGGACTGTGGCTGGACATTCAT

>74725_74725_4_RNF121-ANO1_RNF121_chr11_71671937_ENST00000533380_ANO1_chr11_69933858_ENST00000355303_length(amino acids)=1010AA_BP=60
MEVVLLGNGSWMRVEHARMHAKHRGHEAMHAEMVLILIATLVVAQLLLVQWKQRHPRSYNLLNSLSVDPDAECKYGLYFRDGRRKVDYIL
VYHHKRPSGNRTLVRRVQHSDTPSGARSVKQDHPLPGKGASLDAGSGEPPMDYHEDDKRFRREEYEGNLLEAGLELERDEDTKIHGVGFV
KIHAPWNVLCREAEFLKLKMPTKKMYHINETRGLLKKINSVLQKITDPIQPKVAEHRPQTMKRLSYPFSREKQHLFDLSDKDSFFDSKTR
STIVYEILKRTTCTKAKYSMGITSLLANGVYAAAYPLHDGDYNGENVEFNDRKLLYEEWARYGVFYKYQPIDLVRKYFGEKIGLYFAWLG
VYTQMLIPASIVGIIVFLYGCATMDENIPSMEMCDQRHNITMCPLCDKTCSYWKMSSACATARASHLFDNPATVFFSVFMALWAATFMEH
WKRKQMRLNYRWDLTGFEEEEEAVKDHPRAEYEARVLEKSLKKESRNKEKRRHIPEESTNKWKQRVKTAMAGVKLTDKVKLTWRDRFPAY
LTNLVSIIFMIAVTFAIVLGVIIYRISMAAALAMNSSPSVRSNIRVTVTATAVIINLVVIILLDEVYGCIARWLTKIEVPKTEKSFEERL
IFKAFLLKFVNSYTPIFYVAFFKGRFVGRPGDYVYIFRSFRMEECAPGGCLMELCIQLSIIMLGKQLIQNNLFEIGIPKMKKLIRYLKLK
QQSPPDHEECVKRKQRYEVDYNLEPFAGLTPEYMEMIIQFGFVTLFVASFPLAPLFALLNNIIEIRLDAKKFVTELRRPVAVRAKDIGIW
YNILRGIGKLAVIINAFVISFTSDFIPRLVYLYMYSKNGTMHGFVNHTLSSFNVSDFQNGTAPNDPLDLGYEVQICRYKDYREPPWSENK
YDISKDFWAVLAARLAFVIVFQNLVMFMSDFVDWVIPDIPKDISQQIHKEKVLMVELFMREEQDKQQLLETWMEKERQKDEPPCNHHNTK

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Fusion Gene PPI Analysis for RNF121-ANO1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RNF121-ANO1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RNF121-ANO1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource