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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RNF121-GMPS (FusionGDB2 ID:74731)

Fusion Gene Summary for RNF121-GMPS

check button Fusion gene summary
Fusion gene informationFusion gene name: RNF121-GMPS
Fusion gene ID: 74731
HgeneTgene
Gene symbol

RNF121

GMPS

Gene ID

55298

8833

Gene namering finger protein 121guanine monophosphate synthase
Synonyms-GATD7
Cytomap

11q13.4

3q25.31

Type of geneprotein-codingprotein-coding
DescriptionRING finger protein 121GMP synthase [glutamine-hydrolyzing]GMP synthaseGMP synthetaseMLL/GMPS fusion proteinglutamine amidotransferaseguanine monophosphate synthetaseguanosine 5'-monophosphate synthasetesticular tissue protein Li 82
Modification date2020031320200313
UniProtAcc.

P49915

Ensembl transtripts involved in fusion geneENST00000490867, ENST00000361756, 
ENST00000393713, ENST00000530137, 
ENST00000533380, ENST00000545854, 
ENST00000496455, ENST00000295920, 
ENST00000476145, 
Fusion gene scores* DoF score22 X 8 X 11=19368 X 7 X 6=336
# samples 2711
** MAII scorelog2(27/1936*10)=-2.84204764022376
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/336*10)=-1.6109577092541
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RNF121 [Title/Abstract] AND GMPS [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRNF121(71671937)-GMPS(155611307), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGMPS

GO:0006177

GMP biosynthetic process

8089153


check buttonFusion gene breakpoints across RNF121 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GMPS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-A486-01ARNF121chr11

71671937

+GMPSchr3

155611307

+


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Fusion Gene ORF analysis for RNF121-GMPS

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000490867ENST00000496455RNF121chr11

71671937

+GMPSchr3

155611307

+
3UTR-intronENST00000490867ENST00000295920RNF121chr11

71671937

+GMPSchr3

155611307

+
3UTR-intronENST00000490867ENST00000476145RNF121chr11

71671937

+GMPSchr3

155611307

+
5CDS-intronENST00000361756ENST00000295920RNF121chr11

71671937

+GMPSchr3

155611307

+
5CDS-intronENST00000361756ENST00000476145RNF121chr11

71671937

+GMPSchr3

155611307

+
5CDS-intronENST00000393713ENST00000295920RNF121chr11

71671937

+GMPSchr3

155611307

+
5CDS-intronENST00000393713ENST00000476145RNF121chr11

71671937

+GMPSchr3

155611307

+
5CDS-intronENST00000530137ENST00000295920RNF121chr11

71671937

+GMPSchr3

155611307

+
5CDS-intronENST00000530137ENST00000476145RNF121chr11

71671937

+GMPSchr3

155611307

+
5CDS-intronENST00000533380ENST00000295920RNF121chr11

71671937

+GMPSchr3

155611307

+
5CDS-intronENST00000533380ENST00000476145RNF121chr11

71671937

+GMPSchr3

155611307

+
5UTR-3CDSENST00000545854ENST00000496455RNF121chr11

71671937

+GMPSchr3

155611307

+
5UTR-intronENST00000545854ENST00000295920RNF121chr11

71671937

+GMPSchr3

155611307

+
5UTR-intronENST00000545854ENST00000476145RNF121chr11

71671937

+GMPSchr3

155611307

+
In-frameENST00000361756ENST00000496455RNF121chr11

71671937

+GMPSchr3

155611307

+
In-frameENST00000393713ENST00000496455RNF121chr11

71671937

+GMPSchr3

155611307

+
In-frameENST00000530137ENST00000496455RNF121chr11

71671937

+GMPSchr3

155611307

+
In-frameENST00000533380ENST00000496455RNF121chr11

71671937

+GMPSchr3

155611307

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000361756RNF121chr1171671937+ENST00000496455GMPSchr3155611307+89936043192658779
ENST00000533380RNF121chr1171671937+ENST00000496455GMPSchr3155611307+8624235552289744
ENST00000393713RNF121chr1171671937+ENST00000496455GMPSchr3155611307+8622233532287744
ENST00000530137RNF121chr1171671937+ENST00000496455GMPSchr3155611307+857418552239744

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000361756ENST00000496455RNF121chr1171671937+GMPSchr3155611307+0.000141150.99985886
ENST00000533380ENST00000496455RNF121chr1171671937+GMPSchr3155611307+0.0003870990.999613
ENST00000393713ENST00000496455RNF121chr1171671937+GMPSchr3155611307+0.000387340.9996126
ENST00000530137ENST00000496455RNF121chr1171671937+GMPSchr3155611307+0.0003832170.99961674

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Fusion Genomic Features for RNF121-GMPS


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RNF121chr1171671937+GMPSchr3155611306+8.51E-101
RNF121chr1171671937+GMPSchr3155611306+8.51E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for RNF121-GMPS


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:71671937/chr3:155611307)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GMPS

P49915

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRNF121chr11:71671937chr3:155611307ENST00000361756+3950_7081328.0TransmembraneHelical
TgeneGMPSchr11:71671937chr3:155611307ENST00000496455016217_4359694.0DomainGMPS ATP-PPase
TgeneGMPSchr11:71671937chr3:155611307ENST0000049645501627_2169694.0DomainGlutamine amidotransferase type-1
TgeneGMPSchr11:71671937chr3:155611307ENST00000496455016244_2509694.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRNF121chr11:71671937chr3:155611307ENST00000361756+39100_12081328.0TransmembraneHelical
HgeneRNF121chr11:71671937chr3:155611307ENST00000361756+39148_16881328.0TransmembraneHelical
HgeneRNF121chr11:71671937chr3:155611307ENST00000361756+39172_19281328.0TransmembraneHelical
HgeneRNF121chr11:71671937chr3:155611307ENST00000361756+39306_32681328.0TransmembraneHelical
HgeneRNF121chr11:71671937chr3:155611307ENST00000361756+3979_9981328.0TransmembraneHelical
HgeneRNF121chr11:71671937chr3:155611307ENST00000361756+39226_27681328.0Zinc fingerRING-type%3B atypical


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Fusion Gene Sequence for RNF121-GMPS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>74731_74731_1_RNF121-GMPS_RNF121_chr11_71671937_ENST00000361756_GMPS_chr3_155611307_ENST00000496455_length(transcript)=8993nt_BP=604nt
ACGTCTCGCTCCTTGGAGCCCAGACTGAGGGAGCGTCGCGAAAGTTGCCCGTTTTGGAACGCTCCCATTTGGCTCTCCAAAGGGAAGAAT
TGGTTAAATAGTTGCACTGAAAATAATGCGATTCAAATTTCTCATTTTCCAAGAACGCTCCCTTGCTGAAGCTTGCAAGGGCACGGTACT
CCCCTCTCCTTGACCCTGAAACGTGCAGCAAGTAGATAACCTCCTGATCCCTGACAGTCTCCGCCTGTGTTGATGCCCCGCCCCCTCTGC
TGGAGTCCGAGCCGCCGATTGGCTAGGAGCACTTGAGCAGCGGAAGCAGCTGGCTCGCGCGGGGACTGCGGTGAGGGGGCGAGCCGTGAA
GATGGCGGCAGTGGTGGAGGTGGAGGTTGGAGGTGGTGCTGCTGGGGAACGGGAGCTGGATGAGGTTGATATGTCAGATCTCTCTCCAGA
AGAGCAATGGAGGGTCGAGCACGCACGCATGCATGCCAAGCACCGTGGCCATGAAGCTATGCATGCTGAAATGGTCCTCATCCTCATCGC
AACCTTGGTGGTGGCCCAGCTGCTCCTGGTGCAGTGGAAGCAGAGGCACCCACGCTCCTACAATCTGGAGAATGCTGGAGGAGACCTTAA
GGATGGCCACCACCACTATGAAGGAGCTGTTGTCATTCTGGATGCTGGTGCTCAGTACGGGAAAGTCATAGACCGAAGAGTGAGGGAACT
GTTCGTGCAGTCTGAAATTTTCCCCTTGGAAACACCAGCATTTGCTATAAAGGAACAAGGATTCCGTGCTATTATCATCTCTGGAGGACC
TAATTCTGTGTATGCTGAAGATGCTCCCTGGTTTGATCCAGCAATATTCACTATTGGCAAGCCTGTTCTTGGAATTTGCTATGGTATGCA
GATGATGAATAAGGTATTTGGAGGTACTGTGCACAAAAAAAGTGTCAGAGAAGATGGAGTTTTCAACATTAGTGTGGATAATACATGTTC
ATTATTCAGGGGCCTTCAGAAGGAAGAAGTTGTTTTGCTTACACATGGAGATAGTGTAGACAAAGTAGCTGATGGATTCAAGGTTGTGGC
ACGTTCTGGAAACATAGTAGCAGGCATAGCAAATGAATCTAAAAAGTTATATGGAGCACAGTTCCACCCTGAAGTTGGCCTTACAGAAAA
TGGAAAAGTAATACTGAAGAATTTCCTTTATGATATAGCTGGATGCAGTGGAACCTTCACCGTGCAGAACAGAGAACTTGAGTGTATTCG
AGAGATCAAAGAGAGAGTAGGCACGTCAAAAGTTTTGGTTTTACTCAGTGGTGGAGTAGACTCAACAGTTTGTACAGCTTTGCTAAATCG
TGCTTTGAACCAAGAACAAGTCATTGCTGTGCACATTGATAATGGCTTTATGAGAAAACGAGAAAGCCAGTCTGTTGAAGAGGCCCTCAA
AAAGCTTGGAATTCAGGTCAAAGTGATAAATGCTGCTCATTCTTTCTACAATGGAACAACAACCCTACCAATATCAGATGAAGATAGAAC
CCCACGGAAAAGAATTAGCAAAACGTTAAATATGACCACAAGTCCTGAAGAGAAAAGAAAAATCATTGGGGATACTTTTGTTAAGATTGC
CAATGAAGTAATTGGAGAAATGAACTTGAAACCAGAGGAGGTTTTCCTTGCCCAAGGTACTTTACGGCCTGATCTAATTGAAAGTGCATC
CCTTGTTGCAAGTGGCAAAGCTGAACTCATCAAAACCCATCACAATGACACAGAGCTCATCAGAAAGTTGAGAGAGGAGGGAAAAGTAAT
AGAACCTCTGAAAGATTTTCATAAAGATGAAGTGAGAATTTTGGGCAGAGAACTTGGACTTCCAGAAGAGTTAGTTTCCAGGCATCCATT
TCCAGGTCCTGGCCTGGCAATCAGAGTAATATGTGCTGAAGAACCTTATATTTGTAAGGACTTTCCTGAAACCAACAATATTTTGAAAAT
AGTAGCTGATTTTTCTGCAAGTGTTAAAAAGCCACATACCCTATTACAGAGAGTCAAAGCCTGCACAACAGAAGAGGATCAGGAGAAGCT
GATGCAAATTACCAGTCTGCATTCACTGAATGCCTTCTTGCTGCCAATTAAAACTGTAGGTGTGCAGGGTGACTGTCGTTCCTACAGTTA
CGTGTGTGGAATCTCCAGTAAAGATGAACCTGACTGGGAATCACTTATTTTTCTGGCTAGGCTTATACCTCGCATGTGTCACAACGTTAA
CAGAGTTGTTTATATATTTGGCCCACCAGTTAAAGAACCTCCTACAGATGTTACTCCCACTTTCTTGACAACAGGGGTGCTCAGTACTTT
ACGCCAAGCTGATTTTGAGGCCCATAACATTCTCAGGGAGTCTGGGTATGCTGGGAAAATCAGCCAGATGCCGGTGATTTTGACACCATT
ACATTTTGATCGGGACCCACTTCAAAAGCAGCCTTCATGCCAGAGATCTGTGGTTATTCGAACCTTTATTACTAGTGACTTCATGACTGG
TATACCTGCAACACCTGGCAATGAGATCCCTGTAGAGGTGGTATTAAAGATGGTCACTGAGATTAAGAAGATTCCTGGTATTTCTCGAAT
TATGTATGACTTAACATCAAAGCCCCCAGGAACTACTGAGTGGGAGTAATAAACTTCTTGTTCTATTAAAGTACCGTGTGCAGTTTAAAT
TGATTAGAAATCATTCCCATTATTGACATGCAGTACTGTGAAAAGAGTTACTGGAGCAGCTACATCACATCTGAGTTCTCCACAGCAAAA
ATCTACGGCTTAAGAGCTGAGTTGGGGATAACCAAAAGGGACTGAAGAGTTTGTACGGGTAAATAATCAAAGCACCATTGCCTACACTCA
GACAGATTGATACTGCTTTTGCCTTTGCCTCACTTATTCTTTATGTATAAATTCACTGTTGATGTCTCTGTGAATATGTATGAAGGTGGG
TGAATTTGGGGGTAATTATGGGCTTCTGTCTCCTTACCAGTTTCTAAGAACTGTTAGAAACGCCCATTATTTACCAGTGTTACTTACTAC
TTATATATACTTTTTGGAGAATCAGTTTTCTTATAAGTAATCTTATTTCTCCAAAGGGTGAAAAAGAGATGAACATATCAGATAAAGGTA
TAGGTGGGCTATTCCAGCCACTTTTGAAGGACACTGAGGGTATAAAATGTAAGCTACCATAAGATGGAAAAGCACCAGGAATTTGTTGAT
GTACTTTTGAATTTTATTTCACAGCCTTGGGAGGAAGAAACTATGAGTGGTCTCAGATGTCTATGAATGGTCTTAAAATGTTTTCAAACC
ATGTTCCACATAGATGCCATGTTATTCAATGTCAGCTTGTTTATTAGTAAGGAGCTTTATCCTCCTAGCCTTATATTACCAGCCCCCCAC
AGCCTTGCATAGAAAGTTTCTGTTATCTCCTTAGAAGAAACTGGCTCAATGACGTTTCTGGTGTAGTGCAGATAGAGGTCAAGAGGAGCA
TTTTCATCTCTTCTTTTGCTGGTCAGAGAAACGGTTCTGAGATCACAGAAGCTATGATGCATACCTACAGCTTACAAAAGGGAGAGGAAA
AATGTTTATATCATCTAGTAAACAGTTGTAAAATGAGCTTTTAAATCTAATCTATAGACATATTATTCATTGCTCAGACACCTGTGAACA
GTCTTGATACATGCAAGATGTTTGCCAAACTTTGTAATCCTTTCTACTAGCTATAAGAGAGGATTTAAGAACTGGTGTAGGACTTGTTGC
CATCACCACCAGTTTCTAACAGATCTTTTATAACATTCACATAAGTACTGTAGACAGTAGTAGACTTAAACTCTCCGTTTCTCTCAGTAT
TTTAGCTAAGAATGTTACCATATTTTTCTCTTAACAATTCCATCTCAGGTTGCTGCTGCTTGTCTAGTTTAAAAGGTCAGATCTATTAAT
CAGGAATGAAATTTTATTTGGGATTCAGTGTTAGACAAACAACAAAATGATGCGTGGCAGAAGTCATCTTTTTATTCTGGCTGGTCCAGG
GAACAAGAAAACTGCTGCTGGACCAGCAAGGGAAGAGTTTCTGTCTGTCTTAACAGAAATCTGTCCCCAAGACAAAGGGGTACTTGACTC
CTACAAAACTTAAAGGGTACATTCTCTATCTGATGAGGAGGTACTCATTATGGCCTTCTGGAAAGAGGCTATGTTAGTGATCTGGTCTTT
ACAGATTTAGAGTCATGTTATTTGAAAGCTAGAATAGACAACCTATAAAATGCTTACCAACATGTGTCAGTACACGTTTATGTTTATATG
AAAAAAAATTTCTAGCCACAGTGTCTTATGATTTTGTATTGAAGCAAACAGTAGGAATTTTGGAAAAATAGAGAGTAAGAATGTGTGTTC
TATGGAACACTGCTCCACTGAGAAGGTCCATGTAAAAAGGATTAGGTGGTCATATAAGTTTGGGGAACATAAGCTCACTTGTCCTTTCCT
GGAGATTCATGGTATATAATATTCAAAGCTCTGAGAAATTCTGAAGTTAAAAACAATTGTTAAATTCTGCTTAAATTAGTGTTTTCCTGA
TATTTGTTTTTTGAACACCTTTTATATAATCCCTTCTAATATATACTTAGTATATACTTAATATAATATTGGGAAAATTGTTACTCCAAA
GCACATCTTGACATGACATAGTTTCTTAAAAATCCAAATTTTCTGGAACTCAGAAATTTCCTAATATTTAGCACACTGTCTTCTTTTGCA
CAGCACTTTTTGCTTTGTGCCATATAGCATTACTCTGTACCTTCACAGTATTTCATCTGAGCCACTGAGGAAAGTTAAAGGTTGCACTTC
CATTTTACAGTTAAGAAAACAAGCTCACCTTAGGCATGGTTACTTAATTAATTTCAGAATTAAATTTCAGGTTTCCTTAGTCCAGATTGT
CCTGATGTGTATTCTGACACCTAAAATTATATAAACATTTATGGGATGCTTATTTTACTAAGACTAGAATGGTGGCTACCTGGCTAATAA
CATTCATCATTGGTTATTCTGGGCATATCATGACTTTATTCCCGTTGCTTACCATCTACCTGGGACACATCTCTCTTTGATTAAATATAT
TCTTTTTCTTTGTACTTTTTAGGTAGACAGAGAATGTAGATCATTGAAAGCATTATTTATTCCTAAGATTGGCAGGCACAGAATCATTTT
TAAGAACCAAATACCCAGTCCTGCCTTAAAGGCCACATCTATGATCATCAGCTCTGTTAGAAATAACAGCCTGGCATAATTCCTAAATAC
AAGTCTGTAGATATATCCAGGAGATAGGGTTACACTGTTTTCTAACCTTTTTTAAATCCCTTAATCTTGAGGTAAACTGCATGCATTTAG
TCAAACAAGCATCATAAAATTTGTTTCCTCACTGTTTGGGCTTAACCTCCTGATAGCCTGTTTTACTGAATAACTTGACCCTAACCTGTA
GAGAATAAGAGCATTCAAATTAGGAAGGCAGGACTATCCATCTTTAGTGCTTTTCCTGCCGTTAAACAACAATGTGAACTTGGTCAAGTC
ATTTCTGTTCTTTATCTGTGACATGAGGTAACTGTATTAAATTTTCAGCATCAAATCCAGCTATAAATTTGTATTTTGTAAACAAGAGAA
AGTAAAGCAGGAGACAGAATGGAGAAGCTGGATAGTGTTTTTTTTTTTTTTTTTTAAGGTTCTTTTATCATCAGATATGACACAAAGGGA
AACATCAAAATGCACCGTAAAGTTAAATCCTAGTTACCTTTTTTTGAAGCTGTTGGCAAGGTTTGACCACTTGGGGCATCTTCTGCTGTG
AGATGACACTTGAAAAACACCCATCAAAGTTTTCCTGGTAGGAATCTCTCTTTACTGCGTGTTTTTTTGAAAAGCTGACAGAGAATATGC
TTTGGCTTTGACACTAATGAAGTCACCCATCATCAATTACATACAGCTAATTGTTGGGAGCTAGAGCTAGAATCCAAGCTTTCTGATTCT
CTGCATGGAAGAGGAAATGCTCTAGGGCCCTTCAGGGCAAATCTTAAAAGGAAGTTCTTGGCCGGGCGCGGTGGCTCATGCCTGTAATCC
CAGCACTTTGGGAGGCCGAGGTGGGTGGATCACGAGATCAGGAGATCGAGACCATCTTGGCTAACACGGTGAAACCCCATCTCTACTAAA
AATACAACAAATTAGCTGGGCGCGGTGGCGGGTGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCCTGAACCCAGGAG
GCGGAGCTTGCAGTGAGCTGAGATAGTGCCACTGCACTCCGGCCTGGTGAAAGAGCGAGACTCAGTCTCAAAAAAAAAAAAAAAAGGAAG
TTCTTAGTGTGTAATTGACCATCAGGGATAAATGGGCTTCAAAAGTGTTAATTGTCTCCTTACTTACAGTGAGTTTCTAGAGATAGCCCT
GTCTTTCAGAAATTCTCTGACATCTGCTTGCGCAATGTTATAACCACTTTCCCACACTACTCCCCTCCAGAAATCTCATTGATATGTGGC
GAGGACACGCCTTAGCTATCACCCCAATGGATGCTTCTTTCATTGACCCAAATCCAGAATGTAATGGGGAACTGAATACAAGTTGGATGT
CTCCACCCTTGGAAAGCACATCTTTTGTTCTTACTGAAGTAGTTTAACACCACCAGATGATCAAGGGATCAGGGTATCTTTCTGGTATCT
TTTTAATCACTGAAGGACTTTGACAGCAGTAATGGTGGCATTGTTGACTCTTAAATTTCTGAACGTTTCACTTAATGGCAAGTGAAGAGA
TATAGAATCCCCCAAAGAGTGTCAAGATGCTAACTTCCAACCCTATTTTTATGTACTGAAGAGGCCTCAGTGTCTCACTGAACTCTAACC
TTTTTGTCAGTGTTCCTCAACACTGGATGCGTATTATTACATAACCTGAGGAGTTAAAAAATACAATAACCAGATGTCCAATTAAATAAA
ATTAGAATCTGGAGGAGGTAGAACTCAAGCATTTACAGTTTTGTTTTGTTTTTTTTTTAAGACAGAGTCTCGCTCTGTCCCCAAGTGCAG
TGGCACAATCTCGGCTCACTGCAAGCTCCGCTTCGTGGGTTCACGCCATTCTCCTGCCTCAGTCTCCCGAGTAGCTGGGACTACAGGCGC
CCGCCACTACGCCCGGCTAATTTTTTTGTACTTTTTAGTAGAGACAGGGTTTCACTGTGTTATACAGGATGGTCTCGATCTCCCGACCTC
ATGATCCGCCCGCCTCGGCCTCTCAGAGTGCTGGGATTACAGGCGTGAGCCACCACGCCCGGCAAGCATTTACAGTTTTAAATCTCCCAG
TCAGAATAAATTCTTATTGAGGGCCATACCTAGCCTGTCTTCATCAAACTCATAGGTGAATCTTTGTCAAACCTATAGGAGAGAGATGCA
GGCCATAGAGATGGTCTTGCTGAAGGTCTTATAGCTAAATTAGTTCAGATCCAGGAACCAGATTCTGGAACTGATTGCACCTATATTATG
TTGTGTGTCAGACACTCCCAGGACCTGTTTGGTAATAATTAGGACAGCTGACATACTTGTTGCTAATTTTGAGATCTGGGCAACAACTGT
GTAGGCTGTTCTTTCAACCTCTTTCTTCTTACTTCTTTACTTTTCCTTCAGAGAGGAGAAAGCCACCCCTGTGCTATAGCCACCGCTCCA
ATTCTGACTCTAGCTAGGTCATGAAACAGACTGAGCTATTATTGCATCAACACATAAATCCTGTCATTTGGGTATTATTCTTTAGAGAAC
TAGAGATTACCTAGCTGCAACCTAAGTTTCCTGAATTAGAATCATTTGAGCAGCACCATCTTAATTGGCTCATTAACATATTTGTGACCA
GGCACAGTGGCGCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCTCTTGAGGTCAGGAGTTTGAGACCAGCGTGGCC
AACATGGTGAAACCCCATTTCTACTAAAAATGTAAAAATTAGCTGGGCTTGGTGGCGCGCGCCTGTAATCCCAGCTACTCGGAAGGCTGA
GGTGTGAGAATCACTTAAACCCGGGAGATGGAGGTTGCAGTGAGCAGAGATTGCGCCACTGCACTCCAGCCTAGGTGACAAGAATGAGAC
TCCGTCTTAAAACAAAAACAACATATTTGTTCACTTTTGAACCCTGTGGTGTCTTTTAACTTTGTTAAGGGCCCTTGGTTAGCAAAATTA
TGAAAGTTTAGGAAATTTGGCTATTGAGTATATTAAGTACAACTACAAAATCCTCTGAGTTCTCCAGGAAGCCTAAACCTTGAGCAGTAT
CTTATTCAAGTGGAGTATATATCTTCAAGAATACAGATTTTTAAGGTAAGTAGTTTTTCGTCTTTGCATCTCCTAAGACCATTGTTAACA
ACCTTGATATTAAACGAAGAAGTGAATGTAAACCTCCTTTTGAACATATTTTTTATAAAGAAATATTTTGTTAATTGGAGTAAGTAGTAT
TGTTATGAAATCACTGTGTAATTGTTAATTGTAAACTGCAATGTCTATTTTGTGTTGTAACAATGTTGCCATAAAATAGCTTTGCTAAAT
GTGAAATGACTTTAATCCCTTTTGTCTTCAATATACTTCATAAAGGAGGAAATGATGATTTACACAATTTGTCATGAAGCTTCCGTGTTT
ATGAGAAATTCCAAGAAGTAAGAGCCAAGAGGACAGATATTATCAGAATATGGGACATAAGAAATTGCATATAGTGTCAAGGGTTTCTAT
ATAACAACTTAATTTATTTCCCTTGCATATATAGTAGGGGTTAACATTTTGCTCAATGTTAACGGGGGACATAATGGACATAAAACATTG

>74731_74731_1_RNF121-GMPS_RNF121_chr11_71671937_ENST00000361756_GMPS_chr3_155611307_ENST00000496455_length(amino acids)=779AA_BP=95
MARAGTAVRGRAVKMAAVVEVEVGGGAAGERELDEVDMSDLSPEEQWRVEHARMHAKHRGHEAMHAEMVLILIATLVVAQLLLVQWKQRH
PRSYNLENAGGDLKDGHHHYEGAVVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIIISGGPNSVYAEDAPWFDPAIF
TIGKPVLGICYGMQMMNKVFGGTVHKKSVREDGVFNISVDNTCSLFRGLQKEEVVLLTHGDSVDKVADGFKVVARSGNIVAGIANESKKL
YGAQFHPEVGLTENGKVILKNFLYDIAGCSGTFTVQNRELECIREIKERVGTSKVLVLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGF
MRKRESQSVEEALKKLGIQVKVINAAHSFYNGTTTLPISDEDRTPRKRISKTLNMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPEEVFL
AQGTLRPDLIESASLVASGKAELIKTHHNDTELIRKLREEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHPFPGPGLAIRVICAEEPY
ICKDFPETNNILKIVADFSASVKKPHTLLQRVKACTTEEDQEKLMQITSLHSLNAFLLPIKTVGVQGDCRSYSYVCGISSKDEPDWESLI
FLARLIPRMCHNVNRVVYIFGPPVKEPPTDVTPTFLTTGVLSTLRQADFEAHNILRESGYAGKISQMPVILTPLHFDRDPLQKQPSCQRS

--------------------------------------------------------------
>74731_74731_2_RNF121-GMPS_RNF121_chr11_71671937_ENST00000393713_GMPS_chr3_155611307_ENST00000496455_length(transcript)=8622nt_BP=233nt
GACTGCGGTGAGGGGGCGAGCCGTGAAGATGGCGGCAGTGGTGGAGGTGGAGGTTGGAGGTGGTGCTGCTGGGGAACGGGAGCTGGATGA
GGGTCGAGCACGCACGCATGCATGCCAAGCACCGTGGCCATGAAGCTATGCATGCTGAAATGGTCCTCATCCTCATCGCAACCTTGGTGG
TGGCCCAGCTGCTCCTGGTGCAGTGGAAGCAGAGGCACCCACGCTCCTACAATCTGGAGAATGCTGGAGGAGACCTTAAGGATGGCCACC
ACCACTATGAAGGAGCTGTTGTCATTCTGGATGCTGGTGCTCAGTACGGGAAAGTCATAGACCGAAGAGTGAGGGAACTGTTCGTGCAGT
CTGAAATTTTCCCCTTGGAAACACCAGCATTTGCTATAAAGGAACAAGGATTCCGTGCTATTATCATCTCTGGAGGACCTAATTCTGTGT
ATGCTGAAGATGCTCCCTGGTTTGATCCAGCAATATTCACTATTGGCAAGCCTGTTCTTGGAATTTGCTATGGTATGCAGATGATGAATA
AGGTATTTGGAGGTACTGTGCACAAAAAAAGTGTCAGAGAAGATGGAGTTTTCAACATTAGTGTGGATAATACATGTTCATTATTCAGGG
GCCTTCAGAAGGAAGAAGTTGTTTTGCTTACACATGGAGATAGTGTAGACAAAGTAGCTGATGGATTCAAGGTTGTGGCACGTTCTGGAA
ACATAGTAGCAGGCATAGCAAATGAATCTAAAAAGTTATATGGAGCACAGTTCCACCCTGAAGTTGGCCTTACAGAAAATGGAAAAGTAA
TACTGAAGAATTTCCTTTATGATATAGCTGGATGCAGTGGAACCTTCACCGTGCAGAACAGAGAACTTGAGTGTATTCGAGAGATCAAAG
AGAGAGTAGGCACGTCAAAAGTTTTGGTTTTACTCAGTGGTGGAGTAGACTCAACAGTTTGTACAGCTTTGCTAAATCGTGCTTTGAACC
AAGAACAAGTCATTGCTGTGCACATTGATAATGGCTTTATGAGAAAACGAGAAAGCCAGTCTGTTGAAGAGGCCCTCAAAAAGCTTGGAA
TTCAGGTCAAAGTGATAAATGCTGCTCATTCTTTCTACAATGGAACAACAACCCTACCAATATCAGATGAAGATAGAACCCCACGGAAAA
GAATTAGCAAAACGTTAAATATGACCACAAGTCCTGAAGAGAAAAGAAAAATCATTGGGGATACTTTTGTTAAGATTGCCAATGAAGTAA
TTGGAGAAATGAACTTGAAACCAGAGGAGGTTTTCCTTGCCCAAGGTACTTTACGGCCTGATCTAATTGAAAGTGCATCCCTTGTTGCAA
GTGGCAAAGCTGAACTCATCAAAACCCATCACAATGACACAGAGCTCATCAGAAAGTTGAGAGAGGAGGGAAAAGTAATAGAACCTCTGA
AAGATTTTCATAAAGATGAAGTGAGAATTTTGGGCAGAGAACTTGGACTTCCAGAAGAGTTAGTTTCCAGGCATCCATTTCCAGGTCCTG
GCCTGGCAATCAGAGTAATATGTGCTGAAGAACCTTATATTTGTAAGGACTTTCCTGAAACCAACAATATTTTGAAAATAGTAGCTGATT
TTTCTGCAAGTGTTAAAAAGCCACATACCCTATTACAGAGAGTCAAAGCCTGCACAACAGAAGAGGATCAGGAGAAGCTGATGCAAATTA
CCAGTCTGCATTCACTGAATGCCTTCTTGCTGCCAATTAAAACTGTAGGTGTGCAGGGTGACTGTCGTTCCTACAGTTACGTGTGTGGAA
TCTCCAGTAAAGATGAACCTGACTGGGAATCACTTATTTTTCTGGCTAGGCTTATACCTCGCATGTGTCACAACGTTAACAGAGTTGTTT
ATATATTTGGCCCACCAGTTAAAGAACCTCCTACAGATGTTACTCCCACTTTCTTGACAACAGGGGTGCTCAGTACTTTACGCCAAGCTG
ATTTTGAGGCCCATAACATTCTCAGGGAGTCTGGGTATGCTGGGAAAATCAGCCAGATGCCGGTGATTTTGACACCATTACATTTTGATC
GGGACCCACTTCAAAAGCAGCCTTCATGCCAGAGATCTGTGGTTATTCGAACCTTTATTACTAGTGACTTCATGACTGGTATACCTGCAA
CACCTGGCAATGAGATCCCTGTAGAGGTGGTATTAAAGATGGTCACTGAGATTAAGAAGATTCCTGGTATTTCTCGAATTATGTATGACT
TAACATCAAAGCCCCCAGGAACTACTGAGTGGGAGTAATAAACTTCTTGTTCTATTAAAGTACCGTGTGCAGTTTAAATTGATTAGAAAT
CATTCCCATTATTGACATGCAGTACTGTGAAAAGAGTTACTGGAGCAGCTACATCACATCTGAGTTCTCCACAGCAAAAATCTACGGCTT
AAGAGCTGAGTTGGGGATAACCAAAAGGGACTGAAGAGTTTGTACGGGTAAATAATCAAAGCACCATTGCCTACACTCAGACAGATTGAT
ACTGCTTTTGCCTTTGCCTCACTTATTCTTTATGTATAAATTCACTGTTGATGTCTCTGTGAATATGTATGAAGGTGGGTGAATTTGGGG
GTAATTATGGGCTTCTGTCTCCTTACCAGTTTCTAAGAACTGTTAGAAACGCCCATTATTTACCAGTGTTACTTACTACTTATATATACT
TTTTGGAGAATCAGTTTTCTTATAAGTAATCTTATTTCTCCAAAGGGTGAAAAAGAGATGAACATATCAGATAAAGGTATAGGTGGGCTA
TTCCAGCCACTTTTGAAGGACACTGAGGGTATAAAATGTAAGCTACCATAAGATGGAAAAGCACCAGGAATTTGTTGATGTACTTTTGAA
TTTTATTTCACAGCCTTGGGAGGAAGAAACTATGAGTGGTCTCAGATGTCTATGAATGGTCTTAAAATGTTTTCAAACCATGTTCCACAT
AGATGCCATGTTATTCAATGTCAGCTTGTTTATTAGTAAGGAGCTTTATCCTCCTAGCCTTATATTACCAGCCCCCCACAGCCTTGCATA
GAAAGTTTCTGTTATCTCCTTAGAAGAAACTGGCTCAATGACGTTTCTGGTGTAGTGCAGATAGAGGTCAAGAGGAGCATTTTCATCTCT
TCTTTTGCTGGTCAGAGAAACGGTTCTGAGATCACAGAAGCTATGATGCATACCTACAGCTTACAAAAGGGAGAGGAAAAATGTTTATAT
CATCTAGTAAACAGTTGTAAAATGAGCTTTTAAATCTAATCTATAGACATATTATTCATTGCTCAGACACCTGTGAACAGTCTTGATACA
TGCAAGATGTTTGCCAAACTTTGTAATCCTTTCTACTAGCTATAAGAGAGGATTTAAGAACTGGTGTAGGACTTGTTGCCATCACCACCA
GTTTCTAACAGATCTTTTATAACATTCACATAAGTACTGTAGACAGTAGTAGACTTAAACTCTCCGTTTCTCTCAGTATTTTAGCTAAGA
ATGTTACCATATTTTTCTCTTAACAATTCCATCTCAGGTTGCTGCTGCTTGTCTAGTTTAAAAGGTCAGATCTATTAATCAGGAATGAAA
TTTTATTTGGGATTCAGTGTTAGACAAACAACAAAATGATGCGTGGCAGAAGTCATCTTTTTATTCTGGCTGGTCCAGGGAACAAGAAAA
CTGCTGCTGGACCAGCAAGGGAAGAGTTTCTGTCTGTCTTAACAGAAATCTGTCCCCAAGACAAAGGGGTACTTGACTCCTACAAAACTT
AAAGGGTACATTCTCTATCTGATGAGGAGGTACTCATTATGGCCTTCTGGAAAGAGGCTATGTTAGTGATCTGGTCTTTACAGATTTAGA
GTCATGTTATTTGAAAGCTAGAATAGACAACCTATAAAATGCTTACCAACATGTGTCAGTACACGTTTATGTTTATATGAAAAAAAATTT
CTAGCCACAGTGTCTTATGATTTTGTATTGAAGCAAACAGTAGGAATTTTGGAAAAATAGAGAGTAAGAATGTGTGTTCTATGGAACACT
GCTCCACTGAGAAGGTCCATGTAAAAAGGATTAGGTGGTCATATAAGTTTGGGGAACATAAGCTCACTTGTCCTTTCCTGGAGATTCATG
GTATATAATATTCAAAGCTCTGAGAAATTCTGAAGTTAAAAACAATTGTTAAATTCTGCTTAAATTAGTGTTTTCCTGATATTTGTTTTT
TGAACACCTTTTATATAATCCCTTCTAATATATACTTAGTATATACTTAATATAATATTGGGAAAATTGTTACTCCAAAGCACATCTTGA
CATGACATAGTTTCTTAAAAATCCAAATTTTCTGGAACTCAGAAATTTCCTAATATTTAGCACACTGTCTTCTTTTGCACAGCACTTTTT
GCTTTGTGCCATATAGCATTACTCTGTACCTTCACAGTATTTCATCTGAGCCACTGAGGAAAGTTAAAGGTTGCACTTCCATTTTACAGT
TAAGAAAACAAGCTCACCTTAGGCATGGTTACTTAATTAATTTCAGAATTAAATTTCAGGTTTCCTTAGTCCAGATTGTCCTGATGTGTA
TTCTGACACCTAAAATTATATAAACATTTATGGGATGCTTATTTTACTAAGACTAGAATGGTGGCTACCTGGCTAATAACATTCATCATT
GGTTATTCTGGGCATATCATGACTTTATTCCCGTTGCTTACCATCTACCTGGGACACATCTCTCTTTGATTAAATATATTCTTTTTCTTT
GTACTTTTTAGGTAGACAGAGAATGTAGATCATTGAAAGCATTATTTATTCCTAAGATTGGCAGGCACAGAATCATTTTTAAGAACCAAA
TACCCAGTCCTGCCTTAAAGGCCACATCTATGATCATCAGCTCTGTTAGAAATAACAGCCTGGCATAATTCCTAAATACAAGTCTGTAGA
TATATCCAGGAGATAGGGTTACACTGTTTTCTAACCTTTTTTAAATCCCTTAATCTTGAGGTAAACTGCATGCATTTAGTCAAACAAGCA
TCATAAAATTTGTTTCCTCACTGTTTGGGCTTAACCTCCTGATAGCCTGTTTTACTGAATAACTTGACCCTAACCTGTAGAGAATAAGAG
CATTCAAATTAGGAAGGCAGGACTATCCATCTTTAGTGCTTTTCCTGCCGTTAAACAACAATGTGAACTTGGTCAAGTCATTTCTGTTCT
TTATCTGTGACATGAGGTAACTGTATTAAATTTTCAGCATCAAATCCAGCTATAAATTTGTATTTTGTAAACAAGAGAAAGTAAAGCAGG
AGACAGAATGGAGAAGCTGGATAGTGTTTTTTTTTTTTTTTTTTAAGGTTCTTTTATCATCAGATATGACACAAAGGGAAACATCAAAAT
GCACCGTAAAGTTAAATCCTAGTTACCTTTTTTTGAAGCTGTTGGCAAGGTTTGACCACTTGGGGCATCTTCTGCTGTGAGATGACACTT
GAAAAACACCCATCAAAGTTTTCCTGGTAGGAATCTCTCTTTACTGCGTGTTTTTTTGAAAAGCTGACAGAGAATATGCTTTGGCTTTGA
CACTAATGAAGTCACCCATCATCAATTACATACAGCTAATTGTTGGGAGCTAGAGCTAGAATCCAAGCTTTCTGATTCTCTGCATGGAAG
AGGAAATGCTCTAGGGCCCTTCAGGGCAAATCTTAAAAGGAAGTTCTTGGCCGGGCGCGGTGGCTCATGCCTGTAATCCCAGCACTTTGG
GAGGCCGAGGTGGGTGGATCACGAGATCAGGAGATCGAGACCATCTTGGCTAACACGGTGAAACCCCATCTCTACTAAAAATACAACAAA
TTAGCTGGGCGCGGTGGCGGGTGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCCTGAACCCAGGAGGCGGAGCTTGC
AGTGAGCTGAGATAGTGCCACTGCACTCCGGCCTGGTGAAAGAGCGAGACTCAGTCTCAAAAAAAAAAAAAAAAGGAAGTTCTTAGTGTG
TAATTGACCATCAGGGATAAATGGGCTTCAAAAGTGTTAATTGTCTCCTTACTTACAGTGAGTTTCTAGAGATAGCCCTGTCTTTCAGAA
ATTCTCTGACATCTGCTTGCGCAATGTTATAACCACTTTCCCACACTACTCCCCTCCAGAAATCTCATTGATATGTGGCGAGGACACGCC
TTAGCTATCACCCCAATGGATGCTTCTTTCATTGACCCAAATCCAGAATGTAATGGGGAACTGAATACAAGTTGGATGTCTCCACCCTTG
GAAAGCACATCTTTTGTTCTTACTGAAGTAGTTTAACACCACCAGATGATCAAGGGATCAGGGTATCTTTCTGGTATCTTTTTAATCACT
GAAGGACTTTGACAGCAGTAATGGTGGCATTGTTGACTCTTAAATTTCTGAACGTTTCACTTAATGGCAAGTGAAGAGATATAGAATCCC
CCAAAGAGTGTCAAGATGCTAACTTCCAACCCTATTTTTATGTACTGAAGAGGCCTCAGTGTCTCACTGAACTCTAACCTTTTTGTCAGT
GTTCCTCAACACTGGATGCGTATTATTACATAACCTGAGGAGTTAAAAAATACAATAACCAGATGTCCAATTAAATAAAATTAGAATCTG
GAGGAGGTAGAACTCAAGCATTTACAGTTTTGTTTTGTTTTTTTTTTAAGACAGAGTCTCGCTCTGTCCCCAAGTGCAGTGGCACAATCT
CGGCTCACTGCAAGCTCCGCTTCGTGGGTTCACGCCATTCTCCTGCCTCAGTCTCCCGAGTAGCTGGGACTACAGGCGCCCGCCACTACG
CCCGGCTAATTTTTTTGTACTTTTTAGTAGAGACAGGGTTTCACTGTGTTATACAGGATGGTCTCGATCTCCCGACCTCATGATCCGCCC
GCCTCGGCCTCTCAGAGTGCTGGGATTACAGGCGTGAGCCACCACGCCCGGCAAGCATTTACAGTTTTAAATCTCCCAGTCAGAATAAAT
TCTTATTGAGGGCCATACCTAGCCTGTCTTCATCAAACTCATAGGTGAATCTTTGTCAAACCTATAGGAGAGAGATGCAGGCCATAGAGA
TGGTCTTGCTGAAGGTCTTATAGCTAAATTAGTTCAGATCCAGGAACCAGATTCTGGAACTGATTGCACCTATATTATGTTGTGTGTCAG
ACACTCCCAGGACCTGTTTGGTAATAATTAGGACAGCTGACATACTTGTTGCTAATTTTGAGATCTGGGCAACAACTGTGTAGGCTGTTC
TTTCAACCTCTTTCTTCTTACTTCTTTACTTTTCCTTCAGAGAGGAGAAAGCCACCCCTGTGCTATAGCCACCGCTCCAATTCTGACTCT
AGCTAGGTCATGAAACAGACTGAGCTATTATTGCATCAACACATAAATCCTGTCATTTGGGTATTATTCTTTAGAGAACTAGAGATTACC
TAGCTGCAACCTAAGTTTCCTGAATTAGAATCATTTGAGCAGCACCATCTTAATTGGCTCATTAACATATTTGTGACCAGGCACAGTGGC
GCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCTCTTGAGGTCAGGAGTTTGAGACCAGCGTGGCCAACATGGTGAA
ACCCCATTTCTACTAAAAATGTAAAAATTAGCTGGGCTTGGTGGCGCGCGCCTGTAATCCCAGCTACTCGGAAGGCTGAGGTGTGAGAAT
CACTTAAACCCGGGAGATGGAGGTTGCAGTGAGCAGAGATTGCGCCACTGCACTCCAGCCTAGGTGACAAGAATGAGACTCCGTCTTAAA
ACAAAAACAACATATTTGTTCACTTTTGAACCCTGTGGTGTCTTTTAACTTTGTTAAGGGCCCTTGGTTAGCAAAATTATGAAAGTTTAG
GAAATTTGGCTATTGAGTATATTAAGTACAACTACAAAATCCTCTGAGTTCTCCAGGAAGCCTAAACCTTGAGCAGTATCTTATTCAAGT
GGAGTATATATCTTCAAGAATACAGATTTTTAAGGTAAGTAGTTTTTCGTCTTTGCATCTCCTAAGACCATTGTTAACAACCTTGATATT
AAACGAAGAAGTGAATGTAAACCTCCTTTTGAACATATTTTTTATAAAGAAATATTTTGTTAATTGGAGTAAGTAGTATTGTTATGAAAT
CACTGTGTAATTGTTAATTGTAAACTGCAATGTCTATTTTGTGTTGTAACAATGTTGCCATAAAATAGCTTTGCTAAATGTGAAATGACT
TTAATCCCTTTTGTCTTCAATATACTTCATAAAGGAGGAAATGATGATTTACACAATTTGTCATGAAGCTTCCGTGTTTATGAGAAATTC
CAAGAAGTAAGAGCCAAGAGGACAGATATTATCAGAATATGGGACATAAGAAATTGCATATAGTGTCAAGGGTTTCTATATAACAACTTA
ATTTATTTCCCTTGCATATATAGTAGGGGTTAACATTTTGCTCAATGTTAACGGGGGACATAATGGACATAAAACATTGGATAGCTTTTT

>74731_74731_2_RNF121-GMPS_RNF121_chr11_71671937_ENST00000393713_GMPS_chr3_155611307_ENST00000496455_length(amino acids)=744AA_BP=60
MEVVLLGNGSWMRVEHARMHAKHRGHEAMHAEMVLILIATLVVAQLLLVQWKQRHPRSYNLENAGGDLKDGHHHYEGAVVILDAGAQYGK
VIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIIISGGPNSVYAEDAPWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKSVREDGVF
NISVDNTCSLFRGLQKEEVVLLTHGDSVDKVADGFKVVARSGNIVAGIANESKKLYGAQFHPEVGLTENGKVILKNFLYDIAGCSGTFTV
QNRELECIREIKERVGTSKVLVLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGFMRKRESQSVEEALKKLGIQVKVINAAHSFYNGTTT
LPISDEDRTPRKRISKTLNMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESASLVASGKAELIKTHHNDTELIR
KLREEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHPFPGPGLAIRVICAEEPYICKDFPETNNILKIVADFSASVKKPHTLLQRVKAC
TTEEDQEKLMQITSLHSLNAFLLPIKTVGVQGDCRSYSYVCGISSKDEPDWESLIFLARLIPRMCHNVNRVVYIFGPPVKEPPTDVTPTF
LTTGVLSTLRQADFEAHNILRESGYAGKISQMPVILTPLHFDRDPLQKQPSCQRSVVIRTFITSDFMTGIPATPGNEIPVEVVLKMVTEI

--------------------------------------------------------------
>74731_74731_3_RNF121-GMPS_RNF121_chr11_71671937_ENST00000530137_GMPS_chr3_155611307_ENST00000496455_length(transcript)=8574nt_BP=185nt
GGAGGTTGGAGGTGGTGCTGCTGGGGAACGGGAGCTGGATGAGGGTCGAGCACGCACGCATGCATGCCAAGCACCGTGGCCATGAAGCTA
TGCATGCTGAAATGGTCCTCATCCTCATCGCAACCTTGGTGGTGGCCCAGCTGCTCCTGGTGCAGTGGAAGCAGAGGCACCCACGCTCCT
ACAATCTGGAGAATGCTGGAGGAGACCTTAAGGATGGCCACCACCACTATGAAGGAGCTGTTGTCATTCTGGATGCTGGTGCTCAGTACG
GGAAAGTCATAGACCGAAGAGTGAGGGAACTGTTCGTGCAGTCTGAAATTTTCCCCTTGGAAACACCAGCATTTGCTATAAAGGAACAAG
GATTCCGTGCTATTATCATCTCTGGAGGACCTAATTCTGTGTATGCTGAAGATGCTCCCTGGTTTGATCCAGCAATATTCACTATTGGCA
AGCCTGTTCTTGGAATTTGCTATGGTATGCAGATGATGAATAAGGTATTTGGAGGTACTGTGCACAAAAAAAGTGTCAGAGAAGATGGAG
TTTTCAACATTAGTGTGGATAATACATGTTCATTATTCAGGGGCCTTCAGAAGGAAGAAGTTGTTTTGCTTACACATGGAGATAGTGTAG
ACAAAGTAGCTGATGGATTCAAGGTTGTGGCACGTTCTGGAAACATAGTAGCAGGCATAGCAAATGAATCTAAAAAGTTATATGGAGCAC
AGTTCCACCCTGAAGTTGGCCTTACAGAAAATGGAAAAGTAATACTGAAGAATTTCCTTTATGATATAGCTGGATGCAGTGGAACCTTCA
CCGTGCAGAACAGAGAACTTGAGTGTATTCGAGAGATCAAAGAGAGAGTAGGCACGTCAAAAGTTTTGGTTTTACTCAGTGGTGGAGTAG
ACTCAACAGTTTGTACAGCTTTGCTAAATCGTGCTTTGAACCAAGAACAAGTCATTGCTGTGCACATTGATAATGGCTTTATGAGAAAAC
GAGAAAGCCAGTCTGTTGAAGAGGCCCTCAAAAAGCTTGGAATTCAGGTCAAAGTGATAAATGCTGCTCATTCTTTCTACAATGGAACAA
CAACCCTACCAATATCAGATGAAGATAGAACCCCACGGAAAAGAATTAGCAAAACGTTAAATATGACCACAAGTCCTGAAGAGAAAAGAA
AAATCATTGGGGATACTTTTGTTAAGATTGCCAATGAAGTAATTGGAGAAATGAACTTGAAACCAGAGGAGGTTTTCCTTGCCCAAGGTA
CTTTACGGCCTGATCTAATTGAAAGTGCATCCCTTGTTGCAAGTGGCAAAGCTGAACTCATCAAAACCCATCACAATGACACAGAGCTCA
TCAGAAAGTTGAGAGAGGAGGGAAAAGTAATAGAACCTCTGAAAGATTTTCATAAAGATGAAGTGAGAATTTTGGGCAGAGAACTTGGAC
TTCCAGAAGAGTTAGTTTCCAGGCATCCATTTCCAGGTCCTGGCCTGGCAATCAGAGTAATATGTGCTGAAGAACCTTATATTTGTAAGG
ACTTTCCTGAAACCAACAATATTTTGAAAATAGTAGCTGATTTTTCTGCAAGTGTTAAAAAGCCACATACCCTATTACAGAGAGTCAAAG
CCTGCACAACAGAAGAGGATCAGGAGAAGCTGATGCAAATTACCAGTCTGCATTCACTGAATGCCTTCTTGCTGCCAATTAAAACTGTAG
GTGTGCAGGGTGACTGTCGTTCCTACAGTTACGTGTGTGGAATCTCCAGTAAAGATGAACCTGACTGGGAATCACTTATTTTTCTGGCTA
GGCTTATACCTCGCATGTGTCACAACGTTAACAGAGTTGTTTATATATTTGGCCCACCAGTTAAAGAACCTCCTACAGATGTTACTCCCA
CTTTCTTGACAACAGGGGTGCTCAGTACTTTACGCCAAGCTGATTTTGAGGCCCATAACATTCTCAGGGAGTCTGGGTATGCTGGGAAAA
TCAGCCAGATGCCGGTGATTTTGACACCATTACATTTTGATCGGGACCCACTTCAAAAGCAGCCTTCATGCCAGAGATCTGTGGTTATTC
GAACCTTTATTACTAGTGACTTCATGACTGGTATACCTGCAACACCTGGCAATGAGATCCCTGTAGAGGTGGTATTAAAGATGGTCACTG
AGATTAAGAAGATTCCTGGTATTTCTCGAATTATGTATGACTTAACATCAAAGCCCCCAGGAACTACTGAGTGGGAGTAATAAACTTCTT
GTTCTATTAAAGTACCGTGTGCAGTTTAAATTGATTAGAAATCATTCCCATTATTGACATGCAGTACTGTGAAAAGAGTTACTGGAGCAG
CTACATCACATCTGAGTTCTCCACAGCAAAAATCTACGGCTTAAGAGCTGAGTTGGGGATAACCAAAAGGGACTGAAGAGTTTGTACGGG
TAAATAATCAAAGCACCATTGCCTACACTCAGACAGATTGATACTGCTTTTGCCTTTGCCTCACTTATTCTTTATGTATAAATTCACTGT
TGATGTCTCTGTGAATATGTATGAAGGTGGGTGAATTTGGGGGTAATTATGGGCTTCTGTCTCCTTACCAGTTTCTAAGAACTGTTAGAA
ACGCCCATTATTTACCAGTGTTACTTACTACTTATATATACTTTTTGGAGAATCAGTTTTCTTATAAGTAATCTTATTTCTCCAAAGGGT
GAAAAAGAGATGAACATATCAGATAAAGGTATAGGTGGGCTATTCCAGCCACTTTTGAAGGACACTGAGGGTATAAAATGTAAGCTACCA
TAAGATGGAAAAGCACCAGGAATTTGTTGATGTACTTTTGAATTTTATTTCACAGCCTTGGGAGGAAGAAACTATGAGTGGTCTCAGATG
TCTATGAATGGTCTTAAAATGTTTTCAAACCATGTTCCACATAGATGCCATGTTATTCAATGTCAGCTTGTTTATTAGTAAGGAGCTTTA
TCCTCCTAGCCTTATATTACCAGCCCCCCACAGCCTTGCATAGAAAGTTTCTGTTATCTCCTTAGAAGAAACTGGCTCAATGACGTTTCT
GGTGTAGTGCAGATAGAGGTCAAGAGGAGCATTTTCATCTCTTCTTTTGCTGGTCAGAGAAACGGTTCTGAGATCACAGAAGCTATGATG
CATACCTACAGCTTACAAAAGGGAGAGGAAAAATGTTTATATCATCTAGTAAACAGTTGTAAAATGAGCTTTTAAATCTAATCTATAGAC
ATATTATTCATTGCTCAGACACCTGTGAACAGTCTTGATACATGCAAGATGTTTGCCAAACTTTGTAATCCTTTCTACTAGCTATAAGAG
AGGATTTAAGAACTGGTGTAGGACTTGTTGCCATCACCACCAGTTTCTAACAGATCTTTTATAACATTCACATAAGTACTGTAGACAGTA
GTAGACTTAAACTCTCCGTTTCTCTCAGTATTTTAGCTAAGAATGTTACCATATTTTTCTCTTAACAATTCCATCTCAGGTTGCTGCTGC
TTGTCTAGTTTAAAAGGTCAGATCTATTAATCAGGAATGAAATTTTATTTGGGATTCAGTGTTAGACAAACAACAAAATGATGCGTGGCA
GAAGTCATCTTTTTATTCTGGCTGGTCCAGGGAACAAGAAAACTGCTGCTGGACCAGCAAGGGAAGAGTTTCTGTCTGTCTTAACAGAAA
TCTGTCCCCAAGACAAAGGGGTACTTGACTCCTACAAAACTTAAAGGGTACATTCTCTATCTGATGAGGAGGTACTCATTATGGCCTTCT
GGAAAGAGGCTATGTTAGTGATCTGGTCTTTACAGATTTAGAGTCATGTTATTTGAAAGCTAGAATAGACAACCTATAAAATGCTTACCA
ACATGTGTCAGTACACGTTTATGTTTATATGAAAAAAAATTTCTAGCCACAGTGTCTTATGATTTTGTATTGAAGCAAACAGTAGGAATT
TTGGAAAAATAGAGAGTAAGAATGTGTGTTCTATGGAACACTGCTCCACTGAGAAGGTCCATGTAAAAAGGATTAGGTGGTCATATAAGT
TTGGGGAACATAAGCTCACTTGTCCTTTCCTGGAGATTCATGGTATATAATATTCAAAGCTCTGAGAAATTCTGAAGTTAAAAACAATTG
TTAAATTCTGCTTAAATTAGTGTTTTCCTGATATTTGTTTTTTGAACACCTTTTATATAATCCCTTCTAATATATACTTAGTATATACTT
AATATAATATTGGGAAAATTGTTACTCCAAAGCACATCTTGACATGACATAGTTTCTTAAAAATCCAAATTTTCTGGAACTCAGAAATTT
CCTAATATTTAGCACACTGTCTTCTTTTGCACAGCACTTTTTGCTTTGTGCCATATAGCATTACTCTGTACCTTCACAGTATTTCATCTG
AGCCACTGAGGAAAGTTAAAGGTTGCACTTCCATTTTACAGTTAAGAAAACAAGCTCACCTTAGGCATGGTTACTTAATTAATTTCAGAA
TTAAATTTCAGGTTTCCTTAGTCCAGATTGTCCTGATGTGTATTCTGACACCTAAAATTATATAAACATTTATGGGATGCTTATTTTACT
AAGACTAGAATGGTGGCTACCTGGCTAATAACATTCATCATTGGTTATTCTGGGCATATCATGACTTTATTCCCGTTGCTTACCATCTAC
CTGGGACACATCTCTCTTTGATTAAATATATTCTTTTTCTTTGTACTTTTTAGGTAGACAGAGAATGTAGATCATTGAAAGCATTATTTA
TTCCTAAGATTGGCAGGCACAGAATCATTTTTAAGAACCAAATACCCAGTCCTGCCTTAAAGGCCACATCTATGATCATCAGCTCTGTTA
GAAATAACAGCCTGGCATAATTCCTAAATACAAGTCTGTAGATATATCCAGGAGATAGGGTTACACTGTTTTCTAACCTTTTTTAAATCC
CTTAATCTTGAGGTAAACTGCATGCATTTAGTCAAACAAGCATCATAAAATTTGTTTCCTCACTGTTTGGGCTTAACCTCCTGATAGCCT
GTTTTACTGAATAACTTGACCCTAACCTGTAGAGAATAAGAGCATTCAAATTAGGAAGGCAGGACTATCCATCTTTAGTGCTTTTCCTGC
CGTTAAACAACAATGTGAACTTGGTCAAGTCATTTCTGTTCTTTATCTGTGACATGAGGTAACTGTATTAAATTTTCAGCATCAAATCCA
GCTATAAATTTGTATTTTGTAAACAAGAGAAAGTAAAGCAGGAGACAGAATGGAGAAGCTGGATAGTGTTTTTTTTTTTTTTTTTTAAGG
TTCTTTTATCATCAGATATGACACAAAGGGAAACATCAAAATGCACCGTAAAGTTAAATCCTAGTTACCTTTTTTTGAAGCTGTTGGCAA
GGTTTGACCACTTGGGGCATCTTCTGCTGTGAGATGACACTTGAAAAACACCCATCAAAGTTTTCCTGGTAGGAATCTCTCTTTACTGCG
TGTTTTTTTGAAAAGCTGACAGAGAATATGCTTTGGCTTTGACACTAATGAAGTCACCCATCATCAATTACATACAGCTAATTGTTGGGA
GCTAGAGCTAGAATCCAAGCTTTCTGATTCTCTGCATGGAAGAGGAAATGCTCTAGGGCCCTTCAGGGCAAATCTTAAAAGGAAGTTCTT
GGCCGGGCGCGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGTGGATCACGAGATCAGGAGATCGAGACCATCTTG
GCTAACACGGTGAAACCCCATCTCTACTAAAAATACAACAAATTAGCTGGGCGCGGTGGCGGGTGCCTGTAGTCCCAGCTACTCGGGAGG
CTGAGGCAGGAGAATGGCCTGAACCCAGGAGGCGGAGCTTGCAGTGAGCTGAGATAGTGCCACTGCACTCCGGCCTGGTGAAAGAGCGAG
ACTCAGTCTCAAAAAAAAAAAAAAAAGGAAGTTCTTAGTGTGTAATTGACCATCAGGGATAAATGGGCTTCAAAAGTGTTAATTGTCTCC
TTACTTACAGTGAGTTTCTAGAGATAGCCCTGTCTTTCAGAAATTCTCTGACATCTGCTTGCGCAATGTTATAACCACTTTCCCACACTA
CTCCCCTCCAGAAATCTCATTGATATGTGGCGAGGACACGCCTTAGCTATCACCCCAATGGATGCTTCTTTCATTGACCCAAATCCAGAA
TGTAATGGGGAACTGAATACAAGTTGGATGTCTCCACCCTTGGAAAGCACATCTTTTGTTCTTACTGAAGTAGTTTAACACCACCAGATG
ATCAAGGGATCAGGGTATCTTTCTGGTATCTTTTTAATCACTGAAGGACTTTGACAGCAGTAATGGTGGCATTGTTGACTCTTAAATTTC
TGAACGTTTCACTTAATGGCAAGTGAAGAGATATAGAATCCCCCAAAGAGTGTCAAGATGCTAACTTCCAACCCTATTTTTATGTACTGA
AGAGGCCTCAGTGTCTCACTGAACTCTAACCTTTTTGTCAGTGTTCCTCAACACTGGATGCGTATTATTACATAACCTGAGGAGTTAAAA
AATACAATAACCAGATGTCCAATTAAATAAAATTAGAATCTGGAGGAGGTAGAACTCAAGCATTTACAGTTTTGTTTTGTTTTTTTTTTA
AGACAGAGTCTCGCTCTGTCCCCAAGTGCAGTGGCACAATCTCGGCTCACTGCAAGCTCCGCTTCGTGGGTTCACGCCATTCTCCTGCCT
CAGTCTCCCGAGTAGCTGGGACTACAGGCGCCCGCCACTACGCCCGGCTAATTTTTTTGTACTTTTTAGTAGAGACAGGGTTTCACTGTG
TTATACAGGATGGTCTCGATCTCCCGACCTCATGATCCGCCCGCCTCGGCCTCTCAGAGTGCTGGGATTACAGGCGTGAGCCACCACGCC
CGGCAAGCATTTACAGTTTTAAATCTCCCAGTCAGAATAAATTCTTATTGAGGGCCATACCTAGCCTGTCTTCATCAAACTCATAGGTGA
ATCTTTGTCAAACCTATAGGAGAGAGATGCAGGCCATAGAGATGGTCTTGCTGAAGGTCTTATAGCTAAATTAGTTCAGATCCAGGAACC
AGATTCTGGAACTGATTGCACCTATATTATGTTGTGTGTCAGACACTCCCAGGACCTGTTTGGTAATAATTAGGACAGCTGACATACTTG
TTGCTAATTTTGAGATCTGGGCAACAACTGTGTAGGCTGTTCTTTCAACCTCTTTCTTCTTACTTCTTTACTTTTCCTTCAGAGAGGAGA
AAGCCACCCCTGTGCTATAGCCACCGCTCCAATTCTGACTCTAGCTAGGTCATGAAACAGACTGAGCTATTATTGCATCAACACATAAAT
CCTGTCATTTGGGTATTATTCTTTAGAGAACTAGAGATTACCTAGCTGCAACCTAAGTTTCCTGAATTAGAATCATTTGAGCAGCACCAT
CTTAATTGGCTCATTAACATATTTGTGACCAGGCACAGTGGCGCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCTC
TTGAGGTCAGGAGTTTGAGACCAGCGTGGCCAACATGGTGAAACCCCATTTCTACTAAAAATGTAAAAATTAGCTGGGCTTGGTGGCGCG
CGCCTGTAATCCCAGCTACTCGGAAGGCTGAGGTGTGAGAATCACTTAAACCCGGGAGATGGAGGTTGCAGTGAGCAGAGATTGCGCCAC
TGCACTCCAGCCTAGGTGACAAGAATGAGACTCCGTCTTAAAACAAAAACAACATATTTGTTCACTTTTGAACCCTGTGGTGTCTTTTAA
CTTTGTTAAGGGCCCTTGGTTAGCAAAATTATGAAAGTTTAGGAAATTTGGCTATTGAGTATATTAAGTACAACTACAAAATCCTCTGAG
TTCTCCAGGAAGCCTAAACCTTGAGCAGTATCTTATTCAAGTGGAGTATATATCTTCAAGAATACAGATTTTTAAGGTAAGTAGTTTTTC
GTCTTTGCATCTCCTAAGACCATTGTTAACAACCTTGATATTAAACGAAGAAGTGAATGTAAACCTCCTTTTGAACATATTTTTTATAAA
GAAATATTTTGTTAATTGGAGTAAGTAGTATTGTTATGAAATCACTGTGTAATTGTTAATTGTAAACTGCAATGTCTATTTTGTGTTGTA
ACAATGTTGCCATAAAATAGCTTTGCTAAATGTGAAATGACTTTAATCCCTTTTGTCTTCAATATACTTCATAAAGGAGGAAATGATGAT
TTACACAATTTGTCATGAAGCTTCCGTGTTTATGAGAAATTCCAAGAAGTAAGAGCCAAGAGGACAGATATTATCAGAATATGGGACATA
AGAAATTGCATATAGTGTCAAGGGTTTCTATATAACAACTTAATTTATTTCCCTTGCATATATAGTAGGGGTTAACATTTTGCTCAATGT
TAACGGGGGACATAATGGACATAAAACATTGGATAGCTTTTTATTTAAATGAGCTAAAGGTGTGCGTATACACATGCACTTATAAAATTA

>74731_74731_3_RNF121-GMPS_RNF121_chr11_71671937_ENST00000530137_GMPS_chr3_155611307_ENST00000496455_length(amino acids)=744AA_BP=60
MEVVLLGNGSWMRVEHARMHAKHRGHEAMHAEMVLILIATLVVAQLLLVQWKQRHPRSYNLENAGGDLKDGHHHYEGAVVILDAGAQYGK
VIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIIISGGPNSVYAEDAPWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKSVREDGVF
NISVDNTCSLFRGLQKEEVVLLTHGDSVDKVADGFKVVARSGNIVAGIANESKKLYGAQFHPEVGLTENGKVILKNFLYDIAGCSGTFTV
QNRELECIREIKERVGTSKVLVLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGFMRKRESQSVEEALKKLGIQVKVINAAHSFYNGTTT
LPISDEDRTPRKRISKTLNMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESASLVASGKAELIKTHHNDTELIR
KLREEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHPFPGPGLAIRVICAEEPYICKDFPETNNILKIVADFSASVKKPHTLLQRVKAC
TTEEDQEKLMQITSLHSLNAFLLPIKTVGVQGDCRSYSYVCGISSKDEPDWESLIFLARLIPRMCHNVNRVVYIFGPPVKEPPTDVTPTF
LTTGVLSTLRQADFEAHNILRESGYAGKISQMPVILTPLHFDRDPLQKQPSCQRSVVIRTFITSDFMTGIPATPGNEIPVEVVLKMVTEI

--------------------------------------------------------------
>74731_74731_4_RNF121-GMPS_RNF121_chr11_71671937_ENST00000533380_GMPS_chr3_155611307_ENST00000496455_length(transcript)=8624nt_BP=235nt
GGGACTGCGGTGAGGGGGCGAGCCGTGAAGATGGCGGCAGTGGTGGAGGTGGAGGTTGGAGGTGGTGCTGCTGGGGAACGGGAGCTGGAT
GAGGGTCGAGCACGCACGCATGCATGCCAAGCACCGTGGCCATGAAGCTATGCATGCTGAAATGGTCCTCATCCTCATCGCAACCTTGGT
GGTGGCCCAGCTGCTCCTGGTGCAGTGGAAGCAGAGGCACCCACGCTCCTACAATCTGGAGAATGCTGGAGGAGACCTTAAGGATGGCCA
CCACCACTATGAAGGAGCTGTTGTCATTCTGGATGCTGGTGCTCAGTACGGGAAAGTCATAGACCGAAGAGTGAGGGAACTGTTCGTGCA
GTCTGAAATTTTCCCCTTGGAAACACCAGCATTTGCTATAAAGGAACAAGGATTCCGTGCTATTATCATCTCTGGAGGACCTAATTCTGT
GTATGCTGAAGATGCTCCCTGGTTTGATCCAGCAATATTCACTATTGGCAAGCCTGTTCTTGGAATTTGCTATGGTATGCAGATGATGAA
TAAGGTATTTGGAGGTACTGTGCACAAAAAAAGTGTCAGAGAAGATGGAGTTTTCAACATTAGTGTGGATAATACATGTTCATTATTCAG
GGGCCTTCAGAAGGAAGAAGTTGTTTTGCTTACACATGGAGATAGTGTAGACAAAGTAGCTGATGGATTCAAGGTTGTGGCACGTTCTGG
AAACATAGTAGCAGGCATAGCAAATGAATCTAAAAAGTTATATGGAGCACAGTTCCACCCTGAAGTTGGCCTTACAGAAAATGGAAAAGT
AATACTGAAGAATTTCCTTTATGATATAGCTGGATGCAGTGGAACCTTCACCGTGCAGAACAGAGAACTTGAGTGTATTCGAGAGATCAA
AGAGAGAGTAGGCACGTCAAAAGTTTTGGTTTTACTCAGTGGTGGAGTAGACTCAACAGTTTGTACAGCTTTGCTAAATCGTGCTTTGAA
CCAAGAACAAGTCATTGCTGTGCACATTGATAATGGCTTTATGAGAAAACGAGAAAGCCAGTCTGTTGAAGAGGCCCTCAAAAAGCTTGG
AATTCAGGTCAAAGTGATAAATGCTGCTCATTCTTTCTACAATGGAACAACAACCCTACCAATATCAGATGAAGATAGAACCCCACGGAA
AAGAATTAGCAAAACGTTAAATATGACCACAAGTCCTGAAGAGAAAAGAAAAATCATTGGGGATACTTTTGTTAAGATTGCCAATGAAGT
AATTGGAGAAATGAACTTGAAACCAGAGGAGGTTTTCCTTGCCCAAGGTACTTTACGGCCTGATCTAATTGAAAGTGCATCCCTTGTTGC
AAGTGGCAAAGCTGAACTCATCAAAACCCATCACAATGACACAGAGCTCATCAGAAAGTTGAGAGAGGAGGGAAAAGTAATAGAACCTCT
GAAAGATTTTCATAAAGATGAAGTGAGAATTTTGGGCAGAGAACTTGGACTTCCAGAAGAGTTAGTTTCCAGGCATCCATTTCCAGGTCC
TGGCCTGGCAATCAGAGTAATATGTGCTGAAGAACCTTATATTTGTAAGGACTTTCCTGAAACCAACAATATTTTGAAAATAGTAGCTGA
TTTTTCTGCAAGTGTTAAAAAGCCACATACCCTATTACAGAGAGTCAAAGCCTGCACAACAGAAGAGGATCAGGAGAAGCTGATGCAAAT
TACCAGTCTGCATTCACTGAATGCCTTCTTGCTGCCAATTAAAACTGTAGGTGTGCAGGGTGACTGTCGTTCCTACAGTTACGTGTGTGG
AATCTCCAGTAAAGATGAACCTGACTGGGAATCACTTATTTTTCTGGCTAGGCTTATACCTCGCATGTGTCACAACGTTAACAGAGTTGT
TTATATATTTGGCCCACCAGTTAAAGAACCTCCTACAGATGTTACTCCCACTTTCTTGACAACAGGGGTGCTCAGTACTTTACGCCAAGC
TGATTTTGAGGCCCATAACATTCTCAGGGAGTCTGGGTATGCTGGGAAAATCAGCCAGATGCCGGTGATTTTGACACCATTACATTTTGA
TCGGGACCCACTTCAAAAGCAGCCTTCATGCCAGAGATCTGTGGTTATTCGAACCTTTATTACTAGTGACTTCATGACTGGTATACCTGC
AACACCTGGCAATGAGATCCCTGTAGAGGTGGTATTAAAGATGGTCACTGAGATTAAGAAGATTCCTGGTATTTCTCGAATTATGTATGA
CTTAACATCAAAGCCCCCAGGAACTACTGAGTGGGAGTAATAAACTTCTTGTTCTATTAAAGTACCGTGTGCAGTTTAAATTGATTAGAA
ATCATTCCCATTATTGACATGCAGTACTGTGAAAAGAGTTACTGGAGCAGCTACATCACATCTGAGTTCTCCACAGCAAAAATCTACGGC
TTAAGAGCTGAGTTGGGGATAACCAAAAGGGACTGAAGAGTTTGTACGGGTAAATAATCAAAGCACCATTGCCTACACTCAGACAGATTG
ATACTGCTTTTGCCTTTGCCTCACTTATTCTTTATGTATAAATTCACTGTTGATGTCTCTGTGAATATGTATGAAGGTGGGTGAATTTGG
GGGTAATTATGGGCTTCTGTCTCCTTACCAGTTTCTAAGAACTGTTAGAAACGCCCATTATTTACCAGTGTTACTTACTACTTATATATA
CTTTTTGGAGAATCAGTTTTCTTATAAGTAATCTTATTTCTCCAAAGGGTGAAAAAGAGATGAACATATCAGATAAAGGTATAGGTGGGC
TATTCCAGCCACTTTTGAAGGACACTGAGGGTATAAAATGTAAGCTACCATAAGATGGAAAAGCACCAGGAATTTGTTGATGTACTTTTG
AATTTTATTTCACAGCCTTGGGAGGAAGAAACTATGAGTGGTCTCAGATGTCTATGAATGGTCTTAAAATGTTTTCAAACCATGTTCCAC
ATAGATGCCATGTTATTCAATGTCAGCTTGTTTATTAGTAAGGAGCTTTATCCTCCTAGCCTTATATTACCAGCCCCCCACAGCCTTGCA
TAGAAAGTTTCTGTTATCTCCTTAGAAGAAACTGGCTCAATGACGTTTCTGGTGTAGTGCAGATAGAGGTCAAGAGGAGCATTTTCATCT
CTTCTTTTGCTGGTCAGAGAAACGGTTCTGAGATCACAGAAGCTATGATGCATACCTACAGCTTACAAAAGGGAGAGGAAAAATGTTTAT
ATCATCTAGTAAACAGTTGTAAAATGAGCTTTTAAATCTAATCTATAGACATATTATTCATTGCTCAGACACCTGTGAACAGTCTTGATA
CATGCAAGATGTTTGCCAAACTTTGTAATCCTTTCTACTAGCTATAAGAGAGGATTTAAGAACTGGTGTAGGACTTGTTGCCATCACCAC
CAGTTTCTAACAGATCTTTTATAACATTCACATAAGTACTGTAGACAGTAGTAGACTTAAACTCTCCGTTTCTCTCAGTATTTTAGCTAA
GAATGTTACCATATTTTTCTCTTAACAATTCCATCTCAGGTTGCTGCTGCTTGTCTAGTTTAAAAGGTCAGATCTATTAATCAGGAATGA
AATTTTATTTGGGATTCAGTGTTAGACAAACAACAAAATGATGCGTGGCAGAAGTCATCTTTTTATTCTGGCTGGTCCAGGGAACAAGAA
AACTGCTGCTGGACCAGCAAGGGAAGAGTTTCTGTCTGTCTTAACAGAAATCTGTCCCCAAGACAAAGGGGTACTTGACTCCTACAAAAC
TTAAAGGGTACATTCTCTATCTGATGAGGAGGTACTCATTATGGCCTTCTGGAAAGAGGCTATGTTAGTGATCTGGTCTTTACAGATTTA
GAGTCATGTTATTTGAAAGCTAGAATAGACAACCTATAAAATGCTTACCAACATGTGTCAGTACACGTTTATGTTTATATGAAAAAAAAT
TTCTAGCCACAGTGTCTTATGATTTTGTATTGAAGCAAACAGTAGGAATTTTGGAAAAATAGAGAGTAAGAATGTGTGTTCTATGGAACA
CTGCTCCACTGAGAAGGTCCATGTAAAAAGGATTAGGTGGTCATATAAGTTTGGGGAACATAAGCTCACTTGTCCTTTCCTGGAGATTCA
TGGTATATAATATTCAAAGCTCTGAGAAATTCTGAAGTTAAAAACAATTGTTAAATTCTGCTTAAATTAGTGTTTTCCTGATATTTGTTT
TTTGAACACCTTTTATATAATCCCTTCTAATATATACTTAGTATATACTTAATATAATATTGGGAAAATTGTTACTCCAAAGCACATCTT
GACATGACATAGTTTCTTAAAAATCCAAATTTTCTGGAACTCAGAAATTTCCTAATATTTAGCACACTGTCTTCTTTTGCACAGCACTTT
TTGCTTTGTGCCATATAGCATTACTCTGTACCTTCACAGTATTTCATCTGAGCCACTGAGGAAAGTTAAAGGTTGCACTTCCATTTTACA
GTTAAGAAAACAAGCTCACCTTAGGCATGGTTACTTAATTAATTTCAGAATTAAATTTCAGGTTTCCTTAGTCCAGATTGTCCTGATGTG
TATTCTGACACCTAAAATTATATAAACATTTATGGGATGCTTATTTTACTAAGACTAGAATGGTGGCTACCTGGCTAATAACATTCATCA
TTGGTTATTCTGGGCATATCATGACTTTATTCCCGTTGCTTACCATCTACCTGGGACACATCTCTCTTTGATTAAATATATTCTTTTTCT
TTGTACTTTTTAGGTAGACAGAGAATGTAGATCATTGAAAGCATTATTTATTCCTAAGATTGGCAGGCACAGAATCATTTTTAAGAACCA
AATACCCAGTCCTGCCTTAAAGGCCACATCTATGATCATCAGCTCTGTTAGAAATAACAGCCTGGCATAATTCCTAAATACAAGTCTGTA
GATATATCCAGGAGATAGGGTTACACTGTTTTCTAACCTTTTTTAAATCCCTTAATCTTGAGGTAAACTGCATGCATTTAGTCAAACAAG
CATCATAAAATTTGTTTCCTCACTGTTTGGGCTTAACCTCCTGATAGCCTGTTTTACTGAATAACTTGACCCTAACCTGTAGAGAATAAG
AGCATTCAAATTAGGAAGGCAGGACTATCCATCTTTAGTGCTTTTCCTGCCGTTAAACAACAATGTGAACTTGGTCAAGTCATTTCTGTT
CTTTATCTGTGACATGAGGTAACTGTATTAAATTTTCAGCATCAAATCCAGCTATAAATTTGTATTTTGTAAACAAGAGAAAGTAAAGCA
GGAGACAGAATGGAGAAGCTGGATAGTGTTTTTTTTTTTTTTTTTTAAGGTTCTTTTATCATCAGATATGACACAAAGGGAAACATCAAA
ATGCACCGTAAAGTTAAATCCTAGTTACCTTTTTTTGAAGCTGTTGGCAAGGTTTGACCACTTGGGGCATCTTCTGCTGTGAGATGACAC
TTGAAAAACACCCATCAAAGTTTTCCTGGTAGGAATCTCTCTTTACTGCGTGTTTTTTTGAAAAGCTGACAGAGAATATGCTTTGGCTTT
GACACTAATGAAGTCACCCATCATCAATTACATACAGCTAATTGTTGGGAGCTAGAGCTAGAATCCAAGCTTTCTGATTCTCTGCATGGA
AGAGGAAATGCTCTAGGGCCCTTCAGGGCAAATCTTAAAAGGAAGTTCTTGGCCGGGCGCGGTGGCTCATGCCTGTAATCCCAGCACTTT
GGGAGGCCGAGGTGGGTGGATCACGAGATCAGGAGATCGAGACCATCTTGGCTAACACGGTGAAACCCCATCTCTACTAAAAATACAACA
AATTAGCTGGGCGCGGTGGCGGGTGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCCTGAACCCAGGAGGCGGAGCTT
GCAGTGAGCTGAGATAGTGCCACTGCACTCCGGCCTGGTGAAAGAGCGAGACTCAGTCTCAAAAAAAAAAAAAAAAGGAAGTTCTTAGTG
TGTAATTGACCATCAGGGATAAATGGGCTTCAAAAGTGTTAATTGTCTCCTTACTTACAGTGAGTTTCTAGAGATAGCCCTGTCTTTCAG
AAATTCTCTGACATCTGCTTGCGCAATGTTATAACCACTTTCCCACACTACTCCCCTCCAGAAATCTCATTGATATGTGGCGAGGACACG
CCTTAGCTATCACCCCAATGGATGCTTCTTTCATTGACCCAAATCCAGAATGTAATGGGGAACTGAATACAAGTTGGATGTCTCCACCCT
TGGAAAGCACATCTTTTGTTCTTACTGAAGTAGTTTAACACCACCAGATGATCAAGGGATCAGGGTATCTTTCTGGTATCTTTTTAATCA
CTGAAGGACTTTGACAGCAGTAATGGTGGCATTGTTGACTCTTAAATTTCTGAACGTTTCACTTAATGGCAAGTGAAGAGATATAGAATC
CCCCAAAGAGTGTCAAGATGCTAACTTCCAACCCTATTTTTATGTACTGAAGAGGCCTCAGTGTCTCACTGAACTCTAACCTTTTTGTCA
GTGTTCCTCAACACTGGATGCGTATTATTACATAACCTGAGGAGTTAAAAAATACAATAACCAGATGTCCAATTAAATAAAATTAGAATC
TGGAGGAGGTAGAACTCAAGCATTTACAGTTTTGTTTTGTTTTTTTTTTAAGACAGAGTCTCGCTCTGTCCCCAAGTGCAGTGGCACAAT
CTCGGCTCACTGCAAGCTCCGCTTCGTGGGTTCACGCCATTCTCCTGCCTCAGTCTCCCGAGTAGCTGGGACTACAGGCGCCCGCCACTA
CGCCCGGCTAATTTTTTTGTACTTTTTAGTAGAGACAGGGTTTCACTGTGTTATACAGGATGGTCTCGATCTCCCGACCTCATGATCCGC
CCGCCTCGGCCTCTCAGAGTGCTGGGATTACAGGCGTGAGCCACCACGCCCGGCAAGCATTTACAGTTTTAAATCTCCCAGTCAGAATAA
ATTCTTATTGAGGGCCATACCTAGCCTGTCTTCATCAAACTCATAGGTGAATCTTTGTCAAACCTATAGGAGAGAGATGCAGGCCATAGA
GATGGTCTTGCTGAAGGTCTTATAGCTAAATTAGTTCAGATCCAGGAACCAGATTCTGGAACTGATTGCACCTATATTATGTTGTGTGTC
AGACACTCCCAGGACCTGTTTGGTAATAATTAGGACAGCTGACATACTTGTTGCTAATTTTGAGATCTGGGCAACAACTGTGTAGGCTGT
TCTTTCAACCTCTTTCTTCTTACTTCTTTACTTTTCCTTCAGAGAGGAGAAAGCCACCCCTGTGCTATAGCCACCGCTCCAATTCTGACT
CTAGCTAGGTCATGAAACAGACTGAGCTATTATTGCATCAACACATAAATCCTGTCATTTGGGTATTATTCTTTAGAGAACTAGAGATTA
CCTAGCTGCAACCTAAGTTTCCTGAATTAGAATCATTTGAGCAGCACCATCTTAATTGGCTCATTAACATATTTGTGACCAGGCACAGTG
GCGCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCTCTTGAGGTCAGGAGTTTGAGACCAGCGTGGCCAACATGGTG
AAACCCCATTTCTACTAAAAATGTAAAAATTAGCTGGGCTTGGTGGCGCGCGCCTGTAATCCCAGCTACTCGGAAGGCTGAGGTGTGAGA
ATCACTTAAACCCGGGAGATGGAGGTTGCAGTGAGCAGAGATTGCGCCACTGCACTCCAGCCTAGGTGACAAGAATGAGACTCCGTCTTA
AAACAAAAACAACATATTTGTTCACTTTTGAACCCTGTGGTGTCTTTTAACTTTGTTAAGGGCCCTTGGTTAGCAAAATTATGAAAGTTT
AGGAAATTTGGCTATTGAGTATATTAAGTACAACTACAAAATCCTCTGAGTTCTCCAGGAAGCCTAAACCTTGAGCAGTATCTTATTCAA
GTGGAGTATATATCTTCAAGAATACAGATTTTTAAGGTAAGTAGTTTTTCGTCTTTGCATCTCCTAAGACCATTGTTAACAACCTTGATA
TTAAACGAAGAAGTGAATGTAAACCTCCTTTTGAACATATTTTTTATAAAGAAATATTTTGTTAATTGGAGTAAGTAGTATTGTTATGAA
ATCACTGTGTAATTGTTAATTGTAAACTGCAATGTCTATTTTGTGTTGTAACAATGTTGCCATAAAATAGCTTTGCTAAATGTGAAATGA
CTTTAATCCCTTTTGTCTTCAATATACTTCATAAAGGAGGAAATGATGATTTACACAATTTGTCATGAAGCTTCCGTGTTTATGAGAAAT
TCCAAGAAGTAAGAGCCAAGAGGACAGATATTATCAGAATATGGGACATAAGAAATTGCATATAGTGTCAAGGGTTTCTATATAACAACT
TAATTTATTTCCCTTGCATATATAGTAGGGGTTAACATTTTGCTCAATGTTAACGGGGGACATAATGGACATAAAACATTGGATAGCTTT

>74731_74731_4_RNF121-GMPS_RNF121_chr11_71671937_ENST00000533380_GMPS_chr3_155611307_ENST00000496455_length(amino acids)=744AA_BP=60
MEVVLLGNGSWMRVEHARMHAKHRGHEAMHAEMVLILIATLVVAQLLLVQWKQRHPRSYNLENAGGDLKDGHHHYEGAVVILDAGAQYGK
VIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIIISGGPNSVYAEDAPWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKSVREDGVF
NISVDNTCSLFRGLQKEEVVLLTHGDSVDKVADGFKVVARSGNIVAGIANESKKLYGAQFHPEVGLTENGKVILKNFLYDIAGCSGTFTV
QNRELECIREIKERVGTSKVLVLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGFMRKRESQSVEEALKKLGIQVKVINAAHSFYNGTTT
LPISDEDRTPRKRISKTLNMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESASLVASGKAELIKTHHNDTELIR
KLREEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHPFPGPGLAIRVICAEEPYICKDFPETNNILKIVADFSASVKKPHTLLQRVKAC
TTEEDQEKLMQITSLHSLNAFLLPIKTVGVQGDCRSYSYVCGISSKDEPDWESLIFLARLIPRMCHNVNRVVYIFGPPVKEPPTDVTPTF
LTTGVLSTLRQADFEAHNILRESGYAGKISQMPVILTPLHFDRDPLQKQPSCQRSVVIRTFITSDFMTGIPATPGNEIPVEVVLKMVTEI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RNF121-GMPS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RNF121-GMPS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RNF121-GMPS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource