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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RNF121-PCDH9 (FusionGDB2 ID:74735)

Fusion Gene Summary for RNF121-PCDH9

check button Fusion gene summary
Fusion gene informationFusion gene name: RNF121-PCDH9
Fusion gene ID: 74735
HgeneTgene
Gene symbol

RNF121

PCDH9

Gene ID

55298

5101

Gene namering finger protein 121protocadherin 9
Synonyms--
Cytomap

11q13.4

13q21.32

Type of geneprotein-codingprotein-coding
DescriptionRING finger protein 121protocadherin-9cadherin superfamily protein VR4-11
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000490867, ENST00000361756, 
ENST00000393713, ENST00000530137, 
ENST00000533380, ENST00000545854, 
ENST00000328454, ENST00000377865, 
ENST00000456367, ENST00000544246, 
ENST00000377861, 
Fusion gene scores* DoF score22 X 8 X 11=193613 X 11 X 4=572
# samples 2713
** MAII scorelog2(27/1936*10)=-2.84204764022376
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/572*10)=-2.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RNF121 [Title/Abstract] AND PCDH9 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRNF121(71671937)-PCDH9(66879160), # samples:3
Anticipated loss of major functional domain due to fusion event.RNF121-PCDH9 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
RNF121-PCDH9 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
RNF121-PCDH9 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across RNF121 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PCDH9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-70-6723-01ARNF121chr11

71671937

-PCDH9chr13

66879160

-
ChimerDB4LUSCTCGA-70-6723-01ARNF121chr11

71671937

+PCDH9chr13

66879160

-
ChimerDB4LUSCTCGA-70-6723RNF121chr11

71671937

+PCDH9chr13

66879160

-


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Fusion Gene ORF analysis for RNF121-PCDH9

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000490867ENST00000328454RNF121chr11

71671937

+PCDH9chr13

66879160

-
3UTR-3CDSENST00000490867ENST00000377865RNF121chr11

71671937

+PCDH9chr13

66879160

-
3UTR-3CDSENST00000490867ENST00000456367RNF121chr11

71671937

+PCDH9chr13

66879160

-
3UTR-3CDSENST00000490867ENST00000544246RNF121chr11

71671937

+PCDH9chr13

66879160

-
3UTR-intronENST00000490867ENST00000377861RNF121chr11

71671937

+PCDH9chr13

66879160

-
5CDS-intronENST00000361756ENST00000377861RNF121chr11

71671937

+PCDH9chr13

66879160

-
5CDS-intronENST00000393713ENST00000377861RNF121chr11

71671937

+PCDH9chr13

66879160

-
5CDS-intronENST00000530137ENST00000377861RNF121chr11

71671937

+PCDH9chr13

66879160

-
5CDS-intronENST00000533380ENST00000377861RNF121chr11

71671937

+PCDH9chr13

66879160

-
5UTR-3CDSENST00000545854ENST00000328454RNF121chr11

71671937

+PCDH9chr13

66879160

-
5UTR-3CDSENST00000545854ENST00000377865RNF121chr11

71671937

+PCDH9chr13

66879160

-
5UTR-3CDSENST00000545854ENST00000456367RNF121chr11

71671937

+PCDH9chr13

66879160

-
5UTR-3CDSENST00000545854ENST00000544246RNF121chr11

71671937

+PCDH9chr13

66879160

-
5UTR-intronENST00000545854ENST00000377861RNF121chr11

71671937

+PCDH9chr13

66879160

-
Frame-shiftENST00000361756ENST00000328454RNF121chr11

71671937

+PCDH9chr13

66879160

-
Frame-shiftENST00000361756ENST00000377865RNF121chr11

71671937

+PCDH9chr13

66879160

-
Frame-shiftENST00000361756ENST00000544246RNF121chr11

71671937

+PCDH9chr13

66879160

-
Frame-shiftENST00000393713ENST00000328454RNF121chr11

71671937

+PCDH9chr13

66879160

-
Frame-shiftENST00000393713ENST00000377865RNF121chr11

71671937

+PCDH9chr13

66879160

-
Frame-shiftENST00000393713ENST00000544246RNF121chr11

71671937

+PCDH9chr13

66879160

-
Frame-shiftENST00000530137ENST00000328454RNF121chr11

71671937

+PCDH9chr13

66879160

-
Frame-shiftENST00000530137ENST00000377865RNF121chr11

71671937

+PCDH9chr13

66879160

-
Frame-shiftENST00000530137ENST00000544246RNF121chr11

71671937

+PCDH9chr13

66879160

-
Frame-shiftENST00000533380ENST00000328454RNF121chr11

71671937

+PCDH9chr13

66879160

-
Frame-shiftENST00000533380ENST00000377865RNF121chr11

71671937

+PCDH9chr13

66879160

-
Frame-shiftENST00000533380ENST00000544246RNF121chr11

71671937

+PCDH9chr13

66879160

-
In-frameENST00000361756ENST00000456367RNF121chr11

71671937

+PCDH9chr13

66879160

-
In-frameENST00000393713ENST00000456367RNF121chr11

71671937

+PCDH9chr13

66879160

-
In-frameENST00000530137ENST00000456367RNF121chr11

71671937

+PCDH9chr13

66879160

-
In-frameENST00000533380ENST00000456367RNF121chr11

71671937

+PCDH9chr13

66879160

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000361756RNF121chr1171671937+ENST00000456367PCDH9chr1366879160-251360416951306129
ENST00000533380RNF121chr1171671937+ENST00000456367PCDH9chr1366879160-21442351326937129
ENST00000393713RNF121chr1171671937+ENST00000456367PCDH9chr1366879160-21422331324935129
ENST00000530137RNF121chr1171671937+ENST00000456367PCDH9chr1366879160-20941851276887129

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000361756ENST00000456367RNF121chr1171671937+PCDH9chr1366879160-0.11545520.8845448
ENST00000533380ENST00000456367RNF121chr1171671937+PCDH9chr1366879160-0.0548204330.94517964
ENST00000393713ENST00000456367RNF121chr1171671937+PCDH9chr1366879160-0.0472985060.9527015
ENST00000530137ENST00000456367RNF121chr1171671937+PCDH9chr1366879160-0.079773540.9202265

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Fusion Genomic Features for RNF121-PCDH9


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RNF121-PCDH9


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:71671937/chr13:66879160)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRNF121chr11:71671937chr13:66879160ENST00000361756+3950_7081328.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRNF121chr11:71671937chr13:66879160ENST00000361756+39100_12081328.0TransmembraneHelical
HgeneRNF121chr11:71671937chr13:66879160ENST00000361756+39148_16881328.0TransmembraneHelical
HgeneRNF121chr11:71671937chr13:66879160ENST00000361756+39172_19281328.0TransmembraneHelical
HgeneRNF121chr11:71671937chr13:66879160ENST00000361756+39306_32681328.0TransmembraneHelical
HgeneRNF121chr11:71671937chr13:66879160ENST00000361756+3979_9981328.0TransmembraneHelical
HgeneRNF121chr11:71671937chr13:66879160ENST00000361756+39226_27681328.0Zinc fingerRING-type%3B atypical
TgenePCDH9chr11:71671937chr13:66879160ENST0000032845413143_25210791204.0DomainCadherin 2
TgenePCDH9chr11:71671937chr13:66879160ENST0000032845413253_35810791204.0DomainCadherin 3
TgenePCDH9chr11:71671937chr13:66879160ENST000003284541326_14210791204.0DomainCadherin 1
TgenePCDH9chr11:71671937chr13:66879160ENST0000032845413365_46910791204.0DomainCadherin 4
TgenePCDH9chr11:71671937chr13:66879160ENST0000032845413470_57210791204.0DomainCadherin 5
TgenePCDH9chr11:71671937chr13:66879160ENST0000032845413573_67510791204.0DomainCadherin 6
TgenePCDH9chr11:71671937chr13:66879160ENST0000032845413679_78410791204.0DomainCadherin 7
TgenePCDH9chr11:71671937chr13:66879160ENST0000037786524143_25211131238.0DomainCadherin 2
TgenePCDH9chr11:71671937chr13:66879160ENST0000037786524253_35811131238.0DomainCadherin 3
TgenePCDH9chr11:71671937chr13:66879160ENST000003778652426_14211131238.0DomainCadherin 1
TgenePCDH9chr11:71671937chr13:66879160ENST0000037786524365_46911131238.0DomainCadherin 4
TgenePCDH9chr11:71671937chr13:66879160ENST0000037786524470_57211131238.0DomainCadherin 5
TgenePCDH9chr11:71671937chr13:66879160ENST0000037786524573_67511131238.0DomainCadherin 6
TgenePCDH9chr11:71671937chr13:66879160ENST0000037786524679_78411131238.0DomainCadherin 7
TgenePCDH9chr11:71671937chr13:66879160ENST0000045636724143_25210791204.0DomainCadherin 2
TgenePCDH9chr11:71671937chr13:66879160ENST0000045636724253_35810791204.0DomainCadherin 3
TgenePCDH9chr11:71671937chr13:66879160ENST000004563672426_14210791204.0DomainCadherin 1
TgenePCDH9chr11:71671937chr13:66879160ENST0000045636724365_46910791204.0DomainCadherin 4
TgenePCDH9chr11:71671937chr13:66879160ENST0000045636724470_57210791204.0DomainCadherin 5
TgenePCDH9chr11:71671937chr13:66879160ENST0000045636724573_67510791204.0DomainCadherin 6
TgenePCDH9chr11:71671937chr13:66879160ENST0000045636724679_78410791204.0DomainCadherin 7
TgenePCDH9chr11:71671937chr13:66879160ENST0000054424635143_25211131238.0DomainCadherin 2
TgenePCDH9chr11:71671937chr13:66879160ENST0000054424635253_35811131238.0DomainCadherin 3
TgenePCDH9chr11:71671937chr13:66879160ENST000005442463526_14211131238.0DomainCadherin 1
TgenePCDH9chr11:71671937chr13:66879160ENST0000054424635365_46911131238.0DomainCadherin 4
TgenePCDH9chr11:71671937chr13:66879160ENST0000054424635470_57211131238.0DomainCadherin 5
TgenePCDH9chr11:71671937chr13:66879160ENST0000054424635573_67511131238.0DomainCadherin 6
TgenePCDH9chr11:71671937chr13:66879160ENST0000054424635679_78411131238.0DomainCadherin 7
TgenePCDH9chr11:71671937chr13:66879160ENST000003284541324_81410791204.0Topological domainExtracellular
TgenePCDH9chr11:71671937chr13:66879160ENST0000032845413836_123710791204.0Topological domainCytoplasmic
TgenePCDH9chr11:71671937chr13:66879160ENST000003778652424_81411131238.0Topological domainExtracellular
TgenePCDH9chr11:71671937chr13:66879160ENST0000037786524836_123711131238.0Topological domainCytoplasmic
TgenePCDH9chr11:71671937chr13:66879160ENST000004563672424_81410791204.0Topological domainExtracellular
TgenePCDH9chr11:71671937chr13:66879160ENST0000045636724836_123710791204.0Topological domainCytoplasmic
TgenePCDH9chr11:71671937chr13:66879160ENST000005442463524_81411131238.0Topological domainExtracellular
TgenePCDH9chr11:71671937chr13:66879160ENST0000054424635836_123711131238.0Topological domainCytoplasmic
TgenePCDH9chr11:71671937chr13:66879160ENST0000032845413815_83510791204.0TransmembraneHelical
TgenePCDH9chr11:71671937chr13:66879160ENST0000037786524815_83511131238.0TransmembraneHelical
TgenePCDH9chr11:71671937chr13:66879160ENST0000045636724815_83510791204.0TransmembraneHelical
TgenePCDH9chr11:71671937chr13:66879160ENST0000054424635815_83511131238.0TransmembraneHelical


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Fusion Gene Sequence for RNF121-PCDH9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>74735_74735_1_RNF121-PCDH9_RNF121_chr11_71671937_ENST00000361756_PCDH9_chr13_66879160_ENST00000456367_length(transcript)=2513nt_BP=604nt
ACGTCTCGCTCCTTGGAGCCCAGACTGAGGGAGCGTCGCGAAAGTTGCCCGTTTTGGAACGCTCCCATTTGGCTCTCCAAAGGGAAGAAT
TGGTTAAATAGTTGCACTGAAAATAATGCGATTCAAATTTCTCATTTTCCAAGAACGCTCCCTTGCTGAAGCTTGCAAGGGCACGGTACT
CCCCTCTCCTTGACCCTGAAACGTGCAGCAAGTAGATAACCTCCTGATCCCTGACAGTCTCCGCCTGTGTTGATGCCCCGCCCCCTCTGC
TGGAGTCCGAGCCGCCGATTGGCTAGGAGCACTTGAGCAGCGGAAGCAGCTGGCTCGCGCGGGGACTGCGGTGAGGGGGCGAGCCGTGAA
GATGGCGGCAGTGGTGGAGGTGGAGGTTGGAGGTGGTGCTGCTGGGGAACGGGAGCTGGATGAGGTTGATATGTCAGATCTCTCTCCAGA
AGAGCAATGGAGGGTCGAGCACGCACGCATGCATGCCAAGCACCGTGGCCATGAAGCTATGCATGCTGAAATGGTCCTCATCCTCATCGC
AACCTTGGTGGTGGCCCAGCTGCTCCTGGTGCAGTGGAAGCAGAGGCACCCACGCTCCTACAATATGGGCCTTTGGGTCCCCGAGGATTA
GCTGAAGCTACAGAGATGTGCACTCAAGAGTGCTTGGTTTTGGGTCACTCTGATAATTGCTGGATGCCTCCTGGCTTGGGTCCATATCAA
CACCCCAAATCTCCTCTCTCAACCTTTGCACCCCAGAAAGAATGGGTGAAGAAGGACAAGCTTGTGAATGGGCACACCCTGACCAGAGCC
TGGAAAGAAGACAGCAACAGGAACCAGTTCAATGACCGTAAGCAGTATGGCTCCAATGAAGGCCATTTCAACAATGGCAGCCACATGACA
GACATTCCTCTGGCAAATCTGAAGTCTTATAAGCAAGCAGGAGGTGCTACTGAGAGTCCTAAGGAGCACCAACTCTAAGAAAAGGCTATA
TGGGACCTAATAACTTTAAATAGACATGCTAATACCGTGTGCGTCAGAGCTTTATGTATTCAATAGATCTCTACAACTATGCCCCTTCTA
GCAGGGATACCTATAACTTTGTGTTAGCACCATGGAGAATACAATGTTTTTGCAACATATGAGAGAAGATAGTTCTAGCCATGCAATTTT
GTTTACTAGAATTGATTACACTCTCCAGAGATCTCTCCATTGTGCAAATTTTTTTTATTATTGCATTTTATTTTGACCCTGGACTGCTGC
TATGAACAATAGAATATGCATTTGGAAAGTAAGAAAGTTTCATGGATTAGAGTGACTGAAAAACATATCCAGTTAGAAAATTGTGCTTTT
TTTTTTTTTTTTTTTTTTTTTTGTCATTGATTTGTGCTGGGACTGCTATACTTGACATTATACTGCAAACAAAACTTAAAGAGATAAGCA
TTAAACCTATTGTGCTGTTAACAACGTTAGTGGACACTTGTAAGTCAATCAGTGTTAAAGTATTTGTAAATAGAAGCAAGCTATTATTAA
CAACTTTTGTGTACTTATAATGTTCACCTAAAAATGTTGTAGCATAATTCTGTGTTTTATGGTTGCTTCTGTCCTTCTTTTTATTTACCT
CTTTGTTGTTATTTTTGTTGTTTCTTTCAGTGAGGTGTTTCTGTGTTAGTAGTCTGTCTTGACACACATTGTTCAAACAATCTCAAGCAC
TTGTGTTTAAAAAAGGTTCTGAAATCTTGCTTCTCATATGATAGCTTATGATGCCGGAATTCTGTAAACAATAAAGATGAAAGAAAAAAT
GAAAACTTTATACAAAAAAGGACTTCTGCAAAAGCTTGGAAATTCAGAACCTATTTTTTATCATCTTATTTTCAAAGTAGGCAAAAGCAA
AATCACTTAATTAGTACCATTAAGTGAGAGAGTAATGGAAAACTGTTATCCATCAAAAGTGATATAATATCCTGTACTTGTCACTCATGT
AAAACTAATGTATCAAAATTAGCATATATGGAAGAAAAATCACTATTCAAAAATAGTTTCAATTGGGCAAATGTGTGTCTACAACTTTGT
TGAAATGGCAGAGTCTGTGTTGATCCTCATATACAATAATGTTGTTGTAACACAAGTGTTATTAGACCATAGCCACAAAATATTTAATGT
GTTGTGCCTTCATGATGTAACAGAACATTCTCCAGGTAGGGTAGTTGGGGGAAATAAAGGGATAAATCTCTAATTATTGCTGTTTAACTG
TTTGTTATCATAGTTGGTCAATGCCTGGCAGGTACCAGCATATTGTCACTTAGGTCAAACCAATAAAGTGACAACTAATGTTAATAAGAT
CTCAGTTGCACGTGCAAACAAATCCAAATTCGAACATTCTTAGGAGGTTTTTGTTAAGGCATGACAGATGATTTAAACAAATAAATAGCA

>74735_74735_1_RNF121-PCDH9_RNF121_chr11_71671937_ENST00000361756_PCDH9_chr13_66879160_ENST00000456367_length(amino acids)=129AA_BP=
MNNVCQDRLLTQKHLTERNNKNNNKEVNKKKDRSNHKTQNYATTFLGEHYKYTKVVNNSLLLFTNTLTLIDLQVSTNVVNSTIGLMLISL

--------------------------------------------------------------
>74735_74735_2_RNF121-PCDH9_RNF121_chr11_71671937_ENST00000393713_PCDH9_chr13_66879160_ENST00000456367_length(transcript)=2142nt_BP=233nt
GACTGCGGTGAGGGGGCGAGCCGTGAAGATGGCGGCAGTGGTGGAGGTGGAGGTTGGAGGTGGTGCTGCTGGGGAACGGGAGCTGGATGA
GGGTCGAGCACGCACGCATGCATGCCAAGCACCGTGGCCATGAAGCTATGCATGCTGAAATGGTCCTCATCCTCATCGCAACCTTGGTGG
TGGCCCAGCTGCTCCTGGTGCAGTGGAAGCAGAGGCACCCACGCTCCTACAATATGGGCCTTTGGGTCCCCGAGGATTAGCTGAAGCTAC
AGAGATGTGCACTCAAGAGTGCTTGGTTTTGGGTCACTCTGATAATTGCTGGATGCCTCCTGGCTTGGGTCCATATCAACACCCCAAATC
TCCTCTCTCAACCTTTGCACCCCAGAAAGAATGGGTGAAGAAGGACAAGCTTGTGAATGGGCACACCCTGACCAGAGCCTGGAAAGAAGA
CAGCAACAGGAACCAGTTCAATGACCGTAAGCAGTATGGCTCCAATGAAGGCCATTTCAACAATGGCAGCCACATGACAGACATTCCTCT
GGCAAATCTGAAGTCTTATAAGCAAGCAGGAGGTGCTACTGAGAGTCCTAAGGAGCACCAACTCTAAGAAAAGGCTATATGGGACCTAAT
AACTTTAAATAGACATGCTAATACCGTGTGCGTCAGAGCTTTATGTATTCAATAGATCTCTACAACTATGCCCCTTCTAGCAGGGATACC
TATAACTTTGTGTTAGCACCATGGAGAATACAATGTTTTTGCAACATATGAGAGAAGATAGTTCTAGCCATGCAATTTTGTTTACTAGAA
TTGATTACACTCTCCAGAGATCTCTCCATTGTGCAAATTTTTTTTATTATTGCATTTTATTTTGACCCTGGACTGCTGCTATGAACAATA
GAATATGCATTTGGAAAGTAAGAAAGTTTCATGGATTAGAGTGACTGAAAAACATATCCAGTTAGAAAATTGTGCTTTTTTTTTTTTTTT
TTTTTTTTTTTGTCATTGATTTGTGCTGGGACTGCTATACTTGACATTATACTGCAAACAAAACTTAAAGAGATAAGCATTAAACCTATT
GTGCTGTTAACAACGTTAGTGGACACTTGTAAGTCAATCAGTGTTAAAGTATTTGTAAATAGAAGCAAGCTATTATTAACAACTTTTGTG
TACTTATAATGTTCACCTAAAAATGTTGTAGCATAATTCTGTGTTTTATGGTTGCTTCTGTCCTTCTTTTTATTTACCTCTTTGTTGTTA
TTTTTGTTGTTTCTTTCAGTGAGGTGTTTCTGTGTTAGTAGTCTGTCTTGACACACATTGTTCAAACAATCTCAAGCACTTGTGTTTAAA
AAAGGTTCTGAAATCTTGCTTCTCATATGATAGCTTATGATGCCGGAATTCTGTAAACAATAAAGATGAAAGAAAAAATGAAAACTTTAT
ACAAAAAAGGACTTCTGCAAAAGCTTGGAAATTCAGAACCTATTTTTTATCATCTTATTTTCAAAGTAGGCAAAAGCAAAATCACTTAAT
TAGTACCATTAAGTGAGAGAGTAATGGAAAACTGTTATCCATCAAAAGTGATATAATATCCTGTACTTGTCACTCATGTAAAACTAATGT
ATCAAAATTAGCATATATGGAAGAAAAATCACTATTCAAAAATAGTTTCAATTGGGCAAATGTGTGTCTACAACTTTGTTGAAATGGCAG
AGTCTGTGTTGATCCTCATATACAATAATGTTGTTGTAACACAAGTGTTATTAGACCATAGCCACAAAATATTTAATGTGTTGTGCCTTC
ATGATGTAACAGAACATTCTCCAGGTAGGGTAGTTGGGGGAAATAAAGGGATAAATCTCTAATTATTGCTGTTTAACTGTTTGTTATCAT
AGTTGGTCAATGCCTGGCAGGTACCAGCATATTGTCACTTAGGTCAAACCAATAAAGTGACAACTAATGTTAATAAGATCTCAGTTGCAC
GTGCAAACAAATCCAAATTCGAACATTCTTAGGAGGTTTTTGTTAAGGCATGACAGATGATTTAAACAAATAAATAGCATGCAACAAAAT

>74735_74735_2_RNF121-PCDH9_RNF121_chr11_71671937_ENST00000393713_PCDH9_chr13_66879160_ENST00000456367_length(amino acids)=129AA_BP=
MNNVCQDRLLTQKHLTERNNKNNNKEVNKKKDRSNHKTQNYATTFLGEHYKYTKVVNNSLLLFTNTLTLIDLQVSTNVVNSTIGLMLISL

--------------------------------------------------------------
>74735_74735_3_RNF121-PCDH9_RNF121_chr11_71671937_ENST00000530137_PCDH9_chr13_66879160_ENST00000456367_length(transcript)=2094nt_BP=185nt
GGAGGTTGGAGGTGGTGCTGCTGGGGAACGGGAGCTGGATGAGGGTCGAGCACGCACGCATGCATGCCAAGCACCGTGGCCATGAAGCTA
TGCATGCTGAAATGGTCCTCATCCTCATCGCAACCTTGGTGGTGGCCCAGCTGCTCCTGGTGCAGTGGAAGCAGAGGCACCCACGCTCCT
ACAATATGGGCCTTTGGGTCCCCGAGGATTAGCTGAAGCTACAGAGATGTGCACTCAAGAGTGCTTGGTTTTGGGTCACTCTGATAATTG
CTGGATGCCTCCTGGCTTGGGTCCATATCAACACCCCAAATCTCCTCTCTCAACCTTTGCACCCCAGAAAGAATGGGTGAAGAAGGACAA
GCTTGTGAATGGGCACACCCTGACCAGAGCCTGGAAAGAAGACAGCAACAGGAACCAGTTCAATGACCGTAAGCAGTATGGCTCCAATGA
AGGCCATTTCAACAATGGCAGCCACATGACAGACATTCCTCTGGCAAATCTGAAGTCTTATAAGCAAGCAGGAGGTGCTACTGAGAGTCC
TAAGGAGCACCAACTCTAAGAAAAGGCTATATGGGACCTAATAACTTTAAATAGACATGCTAATACCGTGTGCGTCAGAGCTTTATGTAT
TCAATAGATCTCTACAACTATGCCCCTTCTAGCAGGGATACCTATAACTTTGTGTTAGCACCATGGAGAATACAATGTTTTTGCAACATA
TGAGAGAAGATAGTTCTAGCCATGCAATTTTGTTTACTAGAATTGATTACACTCTCCAGAGATCTCTCCATTGTGCAAATTTTTTTTATT
ATTGCATTTTATTTTGACCCTGGACTGCTGCTATGAACAATAGAATATGCATTTGGAAAGTAAGAAAGTTTCATGGATTAGAGTGACTGA
AAAACATATCCAGTTAGAAAATTGTGCTTTTTTTTTTTTTTTTTTTTTTTTTTGTCATTGATTTGTGCTGGGACTGCTATACTTGACATT
ATACTGCAAACAAAACTTAAAGAGATAAGCATTAAACCTATTGTGCTGTTAACAACGTTAGTGGACACTTGTAAGTCAATCAGTGTTAAA
GTATTTGTAAATAGAAGCAAGCTATTATTAACAACTTTTGTGTACTTATAATGTTCACCTAAAAATGTTGTAGCATAATTCTGTGTTTTA
TGGTTGCTTCTGTCCTTCTTTTTATTTACCTCTTTGTTGTTATTTTTGTTGTTTCTTTCAGTGAGGTGTTTCTGTGTTAGTAGTCTGTCT
TGACACACATTGTTCAAACAATCTCAAGCACTTGTGTTTAAAAAAGGTTCTGAAATCTTGCTTCTCATATGATAGCTTATGATGCCGGAA
TTCTGTAAACAATAAAGATGAAAGAAAAAATGAAAACTTTATACAAAAAAGGACTTCTGCAAAAGCTTGGAAATTCAGAACCTATTTTTT
ATCATCTTATTTTCAAAGTAGGCAAAAGCAAAATCACTTAATTAGTACCATTAAGTGAGAGAGTAATGGAAAACTGTTATCCATCAAAAG
TGATATAATATCCTGTACTTGTCACTCATGTAAAACTAATGTATCAAAATTAGCATATATGGAAGAAAAATCACTATTCAAAAATAGTTT
CAATTGGGCAAATGTGTGTCTACAACTTTGTTGAAATGGCAGAGTCTGTGTTGATCCTCATATACAATAATGTTGTTGTAACACAAGTGT
TATTAGACCATAGCCACAAAATATTTAATGTGTTGTGCCTTCATGATGTAACAGAACATTCTCCAGGTAGGGTAGTTGGGGGAAATAAAG
GGATAAATCTCTAATTATTGCTGTTTAACTGTTTGTTATCATAGTTGGTCAATGCCTGGCAGGTACCAGCATATTGTCACTTAGGTCAAA
CCAATAAAGTGACAACTAATGTTAATAAGATCTCAGTTGCACGTGCAAACAAATCCAAATTCGAACATTCTTAGGAGGTTTTTGTTAAGG
CATGACAGATGATTTAAACAAATAAATAGCATGCAACAAAATGTCTTTATTGAAAGAAGTGGAAGTTATCTTAATGCCACGGTTCACCAT

>74735_74735_3_RNF121-PCDH9_RNF121_chr11_71671937_ENST00000530137_PCDH9_chr13_66879160_ENST00000456367_length(amino acids)=129AA_BP=
MNNVCQDRLLTQKHLTERNNKNNNKEVNKKKDRSNHKTQNYATTFLGEHYKYTKVVNNSLLLFTNTLTLIDLQVSTNVVNSTIGLMLISL

--------------------------------------------------------------
>74735_74735_4_RNF121-PCDH9_RNF121_chr11_71671937_ENST00000533380_PCDH9_chr13_66879160_ENST00000456367_length(transcript)=2144nt_BP=235nt
GGGACTGCGGTGAGGGGGCGAGCCGTGAAGATGGCGGCAGTGGTGGAGGTGGAGGTTGGAGGTGGTGCTGCTGGGGAACGGGAGCTGGAT
GAGGGTCGAGCACGCACGCATGCATGCCAAGCACCGTGGCCATGAAGCTATGCATGCTGAAATGGTCCTCATCCTCATCGCAACCTTGGT
GGTGGCCCAGCTGCTCCTGGTGCAGTGGAAGCAGAGGCACCCACGCTCCTACAATATGGGCCTTTGGGTCCCCGAGGATTAGCTGAAGCT
ACAGAGATGTGCACTCAAGAGTGCTTGGTTTTGGGTCACTCTGATAATTGCTGGATGCCTCCTGGCTTGGGTCCATATCAACACCCCAAA
TCTCCTCTCTCAACCTTTGCACCCCAGAAAGAATGGGTGAAGAAGGACAAGCTTGTGAATGGGCACACCCTGACCAGAGCCTGGAAAGAA
GACAGCAACAGGAACCAGTTCAATGACCGTAAGCAGTATGGCTCCAATGAAGGCCATTTCAACAATGGCAGCCACATGACAGACATTCCT
CTGGCAAATCTGAAGTCTTATAAGCAAGCAGGAGGTGCTACTGAGAGTCCTAAGGAGCACCAACTCTAAGAAAAGGCTATATGGGACCTA
ATAACTTTAAATAGACATGCTAATACCGTGTGCGTCAGAGCTTTATGTATTCAATAGATCTCTACAACTATGCCCCTTCTAGCAGGGATA
CCTATAACTTTGTGTTAGCACCATGGAGAATACAATGTTTTTGCAACATATGAGAGAAGATAGTTCTAGCCATGCAATTTTGTTTACTAG
AATTGATTACACTCTCCAGAGATCTCTCCATTGTGCAAATTTTTTTTATTATTGCATTTTATTTTGACCCTGGACTGCTGCTATGAACAA
TAGAATATGCATTTGGAAAGTAAGAAAGTTTCATGGATTAGAGTGACTGAAAAACATATCCAGTTAGAAAATTGTGCTTTTTTTTTTTTT
TTTTTTTTTTTTTGTCATTGATTTGTGCTGGGACTGCTATACTTGACATTATACTGCAAACAAAACTTAAAGAGATAAGCATTAAACCTA
TTGTGCTGTTAACAACGTTAGTGGACACTTGTAAGTCAATCAGTGTTAAAGTATTTGTAAATAGAAGCAAGCTATTATTAACAACTTTTG
TGTACTTATAATGTTCACCTAAAAATGTTGTAGCATAATTCTGTGTTTTATGGTTGCTTCTGTCCTTCTTTTTATTTACCTCTTTGTTGT
TATTTTTGTTGTTTCTTTCAGTGAGGTGTTTCTGTGTTAGTAGTCTGTCTTGACACACATTGTTCAAACAATCTCAAGCACTTGTGTTTA
AAAAAGGTTCTGAAATCTTGCTTCTCATATGATAGCTTATGATGCCGGAATTCTGTAAACAATAAAGATGAAAGAAAAAATGAAAACTTT
ATACAAAAAAGGACTTCTGCAAAAGCTTGGAAATTCAGAACCTATTTTTTATCATCTTATTTTCAAAGTAGGCAAAAGCAAAATCACTTA
ATTAGTACCATTAAGTGAGAGAGTAATGGAAAACTGTTATCCATCAAAAGTGATATAATATCCTGTACTTGTCACTCATGTAAAACTAAT
GTATCAAAATTAGCATATATGGAAGAAAAATCACTATTCAAAAATAGTTTCAATTGGGCAAATGTGTGTCTACAACTTTGTTGAAATGGC
AGAGTCTGTGTTGATCCTCATATACAATAATGTTGTTGTAACACAAGTGTTATTAGACCATAGCCACAAAATATTTAATGTGTTGTGCCT
TCATGATGTAACAGAACATTCTCCAGGTAGGGTAGTTGGGGGAAATAAAGGGATAAATCTCTAATTATTGCTGTTTAACTGTTTGTTATC
ATAGTTGGTCAATGCCTGGCAGGTACCAGCATATTGTCACTTAGGTCAAACCAATAAAGTGACAACTAATGTTAATAAGATCTCAGTTGC
ACGTGCAAACAAATCCAAATTCGAACATTCTTAGGAGGTTTTTGTTAAGGCATGACAGATGATTTAAACAAATAAATAGCATGCAACAAA

>74735_74735_4_RNF121-PCDH9_RNF121_chr11_71671937_ENST00000533380_PCDH9_chr13_66879160_ENST00000456367_length(amino acids)=129AA_BP=
MNNVCQDRLLTQKHLTERNNKNNNKEVNKKKDRSNHKTQNYATTFLGEHYKYTKVVNNSLLLFTNTLTLIDLQVSTNVVNSTIGLMLISL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RNF121-PCDH9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RNF121-PCDH9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RNF121-PCDH9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource