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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RNF13-ATP8A2 (FusionGDB2 ID:74793)

Fusion Gene Summary for RNF13-ATP8A2

check button Fusion gene summary
Fusion gene informationFusion gene name: RNF13-ATP8A2
Fusion gene ID: 74793
HgeneTgene
Gene symbol

RNF13

ATP8A2

Gene ID

11342

51761

Gene namering finger protein 13ATPase phospholipid transporting 8A2
SynonymsEIEE73|RZFATP|ATPIB|CAMRQ4|IB|ML-1
Cytomap

3q25.1

13q12.13

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase RNF13RING zinc finger proteinRING-type E3 ubiquitin transferase RNF13phospholipid-transporting ATPase IBATPase, aminophospholipid transporter, class I, type 8A, member 2ATPase, aminophospholipid transporter-like, class I, type 8A, member 2P4-ATPase flippase complex alpha subunit ATP8A2probable phospholipid-transporting
Modification date2020031320200329
UniProtAcc.

Q9NTI2

Ensembl transtripts involved in fusion geneENST00000344229, ENST00000392894, 
ENST00000361785, 		ENST00000491840, 
ENST00000255283, ENST00000381655, 
Fusion gene scores* DoF score10 X 9 X 7=63013 X 13 X 7=1183
# samples 1315
** MAII scorelog2(13/630*10)=-2.27684020535882
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1183*10)=-2.97941566784391
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RNF13 [Title/Abstract] AND ATP8A2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRNF13(149570383)-ATP8A2(26273311), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across RNF13 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ATP8A2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A7-A4SE-01ARNF13chr3

149570383

-ATP8A2chr13

26273311

+


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Fusion Gene ORF analysis for RNF13-ATP8A2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000344229ENST00000491840RNF13chr3

149570383

-ATP8A2chr13

26273311

+
5CDS-3UTRENST00000392894ENST00000491840RNF13chr3

149570383

-ATP8A2chr13

26273311

+
In-frameENST00000344229ENST00000255283RNF13chr3

149570383

-ATP8A2chr13

26273311

+
In-frameENST00000344229ENST00000381655RNF13chr3

149570383

-ATP8A2chr13

26273311

+
In-frameENST00000392894ENST00000255283RNF13chr3

149570383

-ATP8A2chr13

26273311

+
In-frameENST00000392894ENST00000381655RNF13chr3

149570383

-ATP8A2chr13

26273311

+
intron-3CDSENST00000361785ENST00000255283RNF13chr3

149570383

-ATP8A2chr13

26273311

+
intron-3CDSENST00000361785ENST00000381655RNF13chr3

149570383

-ATP8A2chr13

26273311

+
intron-3UTRENST00000361785ENST00000491840RNF13chr3

149570383

-ATP8A2chr13

26273311

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000392894RNF13chr3149570383-ENST00000381655ATP8A2chr1326273311+80798576622212516
ENST00000392894RNF13chr3149570383-ENST00000255283ATP8A2chr1326273311+23948576622137491
ENST00000344229RNF13chr3149570383-ENST00000381655ATP8A2chr1326273311+81198977022252516
ENST00000344229RNF13chr3149570383-ENST00000255283ATP8A2chr1326273311+24348977022177491

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000392894ENST00000381655RNF13chr3149570383-ATP8A2chr1326273311+0.0006739920.999326
ENST00000392894ENST00000255283RNF13chr3149570383-ATP8A2chr1326273311+0.0036534810.99634653
ENST00000344229ENST00000381655RNF13chr3149570383-ATP8A2chr1326273311+0.0007283990.9992716
ENST00000344229ENST00000255283RNF13chr3149570383-ATP8A2chr1326273311+0.0041454310.9958546

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Fusion Genomic Features for RNF13-ATP8A2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RNF13-ATP8A2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:149570383/chr13:26273311)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ATP8A2

Q9NTI2

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Reconstituted to liposomes, the ATP8A2:TMEM30A flippase complex predominantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). Phospholipid translocation is not associated with a countertransport of an inorganic ion or other charged substrate from the cytoplasmic side toward the exoplasm in connection with the phosphorylation from ATP. ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth. Proposed to function in the generation and maintenance of phospholipid asymmetry in photoreceptor disk membranes and neuronal axon membranes. May be involved in vesicle trafficking in neuronal cells. Required for normal visual and auditory function; involved in photoreceptor and inner ear spiral ganglion cell survival. {ECO:0000250|UniProtKB:C7EXK4}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneATP8A2chr3:149570383chr13:26273311ENST0000038165523371019_10287371189.0Topological domainCytoplasmic
TgeneATP8A2chr3:149570383chr13:26273311ENST0000038165523371050_10637371189.0Topological domainExtracellular
TgeneATP8A2chr3:149570383chr13:26273311ENST0000038165523371085_11887371189.0Topological domainCytoplasmic
TgeneATP8A2chr3:149570383chr13:26273311ENST000003816552337909_9107371189.0Topological domainExtracellular
TgeneATP8A2chr3:149570383chr13:26273311ENST000003816552337932_9597371189.0Topological domainCytoplasmic
TgeneATP8A2chr3:149570383chr13:26273311ENST000003816552337981_9977371189.0Topological domainExtracellular
TgeneATP8A2chr3:149570383chr13:26273311ENST0000038165523371029_10497371189.0TransmembraneHelical
TgeneATP8A2chr3:149570383chr13:26273311ENST0000038165523371064_10847371189.0TransmembraneHelical
TgeneATP8A2chr3:149570383chr13:26273311ENST000003816552337888_9087371189.0TransmembraneHelical
TgeneATP8A2chr3:149570383chr13:26273311ENST000003816552337911_9317371189.0TransmembraneHelical
TgeneATP8A2chr3:149570383chr13:26273311ENST000003816552337960_9807371189.0TransmembraneHelical
TgeneATP8A2chr3:149570383chr13:26273311ENST000003816552337998_10187371189.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRNF13chr3:149570383chr13:26273311ENST00000344229-41165_16065382.0DomainNote=PA
HgeneRNF13chr3:149570383chr13:26273311ENST00000392894-31065_16065382.0DomainNote=PA
HgeneRNF13chr3:149570383chr13:26273311ENST00000344229-411204_38165382.0Topological domainCytoplasmic
HgeneRNF13chr3:149570383chr13:26273311ENST00000344229-41135_18265382.0Topological domainLumenal
HgeneRNF13chr3:149570383chr13:26273311ENST00000392894-310204_38165382.0Topological domainCytoplasmic
HgeneRNF13chr3:149570383chr13:26273311ENST00000392894-31035_18265382.0Topological domainLumenal
HgeneRNF13chr3:149570383chr13:26273311ENST00000344229-411183_20365382.0TransmembraneHelical
HgeneRNF13chr3:149570383chr13:26273311ENST00000392894-310183_20365382.0TransmembraneHelical
HgeneRNF13chr3:149570383chr13:26273311ENST00000344229-411240_28265382.0Zinc fingerRING-type%3B atypical
HgeneRNF13chr3:149570383chr13:26273311ENST00000392894-310240_28265382.0Zinc fingerRING-type%3B atypical
TgeneATP8A2chr3:149570383chr13:26273311ENST000003816552337116_1197371189.0Topological domainExtracellular
TgeneATP8A2chr3:149570383chr13:26273311ENST000003816552337141_3167371189.0Topological domainCytoplasmic
TgeneATP8A2chr3:149570383chr13:26273311ENST0000038165523371_947371189.0Topological domainCytoplasmic
TgeneATP8A2chr3:149570383chr13:26273311ENST000003816552337338_3647371189.0Topological domainExtracellular
TgeneATP8A2chr3:149570383chr13:26273311ENST000003816552337386_8877371189.0Topological domainCytoplasmic
TgeneATP8A2chr3:149570383chr13:26273311ENST000003816552337120_1407371189.0TransmembraneHelical
TgeneATP8A2chr3:149570383chr13:26273311ENST000003816552337317_3377371189.0TransmembraneHelical
TgeneATP8A2chr3:149570383chr13:26273311ENST000003816552337365_3857371189.0TransmembraneHelical
TgeneATP8A2chr3:149570383chr13:26273311ENST00000381655233795_1157371189.0TransmembraneHelical


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Fusion Gene Sequence for RNF13-ATP8A2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>74793_74793_1_RNF13-ATP8A2_RNF13_chr3_149570383_ENST00000344229_ATP8A2_chr13_26273311_ENST00000255283_length(transcript)=2434nt_BP=897nt
CCCGCCCGGGGGCAGCCCGGCAGCCGAATCTTGGGCTACTCTGTCCCAACAGCCGGAGCAGATCAGACCGACCGGCCCTGCCCGCTCGGT
CCCGCGCCCTCCAGACCCTACGGTCTCCGTTTCTAGGGGCACATGGTTAGCGGCAGGCGCCCACAGCCAATCCACTTTGCCAGCCTGCCC
CTTCCTCTGCCAAGAGCAGCTTCTTCAGCCGCGCTCCAGTTCCGCAGACGCCTGCCCCACCCTGCTCTTCCCTTCCAGGGAAGACGGATC
ACGCGGCCAAGAACGAGACTCGCAAACTGGGCATTTCTCCGAGCCGGGCTAGAGCAAGTAGCGAGACTCCGCGTGAGAGTGGGAAAGAGC
CTTAACAGGCAACCATGTTGCCCAGTGGGTTTTCTGTGCCTTTGGGTGCGGACCAATGAGGCGCGTGGGGCGGGACTTCCGCTTCGCCTA
GGTGTTGTCGTCCCTGCTAGTACTCCGGGCTGTGGGGGTCGGTGCGGATATTCAGTCATGAAATCAGGGTAGGGACTTCTCCCGCAGCGA
CGCGGCTGGCAAGACTGTTTGTGTTGCGGGGGCCGGACTTCAAGAGAGAAAGAGAGAGTGGGCAGACATCGAAGCCAAACAGCAGTATCC
CGGAAGCACTCATGCAACTTTGGTGGCGGCCACTCAGTTTTCTCTGCCAGTGTCTGGTGATTTTACAACGAGATGCTGCTCTCCATAGGG
ATGCTCATGCTGTCAGCCACACAAGTCTACACCATCTTGACTGTCCAGCTCTTTGCATTCTTAAACCTACTGCCTGTAGAAGCAGACATT
TTAGCATATAACTTTGAAAATGCATCTCAGACATTTGATGACCTCCCTGCAAGATTTGGTTATAGACTTCCAGCTGAAGGTTTAAAGGCC
ACAAGGGCAGCCATTACTCAGCACTGCACTGACCTTGGGAATTTGCTGGGCAAGGAAAATGACGTGGCCCTGATCATCGATGGCCACACC
CTGAAGTACGCGCTCTCCTTCGAAGTCCGGAGGAGTTTCCTGGATTTGGCACTCTCGTGCAAAGCGGTCATATGCTGCAGAGTGTCTCCT
CTGCAGAAGTCTGAGATAGTGGATGTGGTGAAGAAGCGGGTGAAGGCCATCACCCTCGCCATCGGAGACGGCGCCAACGATGTCGGGATG
ATCCAGACAGCCCACGTGGGTGTGGGAATCAGTGGGAATGAAGGCATGCAGGCCACCAACAACTCGGATTACGCCATCGCACAGTTTTCC
TACTTAGAGAAGCTTCTGTTGGTTCATGGAGCCTGGAGCTACAACCGGGTGACCAAGTGCATCTTGTACTGCTTCTATAAGAACGTGGTC
CTGTATATTATTGAGATTTTCACCGCTTTGCCGCCCTTCACTCTGGGAATCTTTGAGAGGTCTTGCACTCAGGAGAGCATGCTCAGGTTT
CCCCAGCTCTACAAAATCACCCAGAATGGCGAAGGCTTCAACACAAAGGTTTTCTGGGGTCACTGCATCAACGCCTTGGTCCACTCCCTC
ATCCTCTTCTGGTTTCCCATGAAAGCTCTGGAGCATGATACTGTGTTGACAAGTGGTCATGCTACCGACTATTTATTTGTTGGAAATATT
GTTTACACATATGTTGTTGTTACTGTTTGTCTGAAAGCTGGTTTGGAGACCACAGCTTGGACTAAATTCAGTCATCTGGCTGTCTGGGGA
AGCATGCTGACCTGGCTGGTGTTTTTTGGCATCTACTCGACCATCTGGCCCACCATTCCCATTGCTCCAGATATGAGAGGACAGGCAACT
ATGGTCCTGAGCTCCGCACACTTCTGGTTGGGATTATTTCTGGTTCCTACTGCCTGTTTGATTGAAGATGTGGCATGGAGAGCAGCCAAG
CACACCTGCAAAAAGACATTGCTGGAGGAGGTGCAGGAGCTGGAAACCAAGTCTCGAGTCCTGGGAAAAGCGGTGCTGCGGGATAGCAAT
GGAAAGAGGCTGAACGAGCGCGACCGCCTGATCAAGAGGCTGGGCCGGAAGACGCCCCCGACGCTGTTCCGGGGCAGCTCCCTGCAGCAG
GGCGTCCCGCATGGGTATGCTTTTTCTCAAGAAGAACACGGAGCTGTTAGTCAGGAAGAAGTCATCCGTGCTTATGACACCACCAAAAAG
AAATCCAGGAAGAAATAAGACATGAATTTTCCTGACTGATCTTAGGAAAGAGATTCAGTTTGTTGCACCCAGTGTTAACACATCTTTGTC
AGAGAAGACTGGCGTCAGCAGCCAAAACACCAGGAAACACATTTCTGTGGCCTTAGCCAAGCAGTTTGTTAGTTACATATTCCCTCGCAA
ACCTGGAGTGCAGACCACAGGGGAAGCTATCTTTGCCCTCCCAACTCGTCTGCAGTGCTTAGCCTAACTTTTGTTTATGTCGTTATGAAG

>74793_74793_1_RNF13-ATP8A2_RNF13_chr3_149570383_ENST00000344229_ATP8A2_chr13_26273311_ENST00000255283_length(amino acids)=491AA_BP=65
MLLSIGMLMLSATQVYTILTVQLFAFLNLLPVEADILAYNFENASQTFDDLPARFGYRLPAEGLKATRAAITQHCTDLGNLLGKENDVAL
IIDGHTLKYALSFEVRRSFLDLALSCKAVICCRVSPLQKSEIVDVVKKRVKAITLAIGDGANDVGMIQTAHVGVGISGNEGMQATNNSDY
AIAQFSYLEKLLLVHGAWSYNRVTKCILYCFYKNVVLYIIEIFTALPPFTLGIFERSCTQESMLRFPQLYKITQNGEGFNTKVFWGHCIN
ALVHSLILFWFPMKALEHDTVLTSGHATDYLFVGNIVYTYVVVTVCLKAGLETTAWTKFSHLAVWGSMLTWLVFFGIYSTIWPTIPIAPD
MRGQATMVLSSAHFWLGLFLVPTACLIEDVAWRAAKHTCKKTLLEEVQELETKSRVLGKAVLRDSNGKRLNERDRLIKRLGRKTPPTLFR

--------------------------------------------------------------
>74793_74793_2_RNF13-ATP8A2_RNF13_chr3_149570383_ENST00000344229_ATP8A2_chr13_26273311_ENST00000381655_length(transcript)=8119nt_BP=897nt
CCCGCCCGGGGGCAGCCCGGCAGCCGAATCTTGGGCTACTCTGTCCCAACAGCCGGAGCAGATCAGACCGACCGGCCCTGCCCGCTCGGT
CCCGCGCCCTCCAGACCCTACGGTCTCCGTTTCTAGGGGCACATGGTTAGCGGCAGGCGCCCACAGCCAATCCACTTTGCCAGCCTGCCC
CTTCCTCTGCCAAGAGCAGCTTCTTCAGCCGCGCTCCAGTTCCGCAGACGCCTGCCCCACCCTGCTCTTCCCTTCCAGGGAAGACGGATC
ACGCGGCCAAGAACGAGACTCGCAAACTGGGCATTTCTCCGAGCCGGGCTAGAGCAAGTAGCGAGACTCCGCGTGAGAGTGGGAAAGAGC
CTTAACAGGCAACCATGTTGCCCAGTGGGTTTTCTGTGCCTTTGGGTGCGGACCAATGAGGCGCGTGGGGCGGGACTTCCGCTTCGCCTA
GGTGTTGTCGTCCCTGCTAGTACTCCGGGCTGTGGGGGTCGGTGCGGATATTCAGTCATGAAATCAGGGTAGGGACTTCTCCCGCAGCGA
CGCGGCTGGCAAGACTGTTTGTGTTGCGGGGGCCGGACTTCAAGAGAGAAAGAGAGAGTGGGCAGACATCGAAGCCAAACAGCAGTATCC
CGGAAGCACTCATGCAACTTTGGTGGCGGCCACTCAGTTTTCTCTGCCAGTGTCTGGTGATTTTACAACGAGATGCTGCTCTCCATAGGG
ATGCTCATGCTGTCAGCCACACAAGTCTACACCATCTTGACTGTCCAGCTCTTTGCATTCTTAAACCTACTGCCTGTAGAAGCAGACATT
TTAGCATATAACTTTGAAAATGCATCTCAGACATTTGATGACCTCCCTGCAAGATTTGGTTATAGACTTCCAGCTGAAGGTTTAAAGGCC
ACAAGGGCAGCCATTACTCAGCACTGCACTGACCTTGGGAATTTGCTGGGCAAGGAAAATGACGTGGCCCTGATCATCGATGGCCACACC
CTGAAGTACGCGCTCTCCTTCGAAGTCCGGAGGAGTTTCCTGGATTTGGCACTCTCGTGCAAAGCGGTCATATGCTGCAGAGTGTCTCCT
CTGCAGAAGTCTGAGATAGTGGATGTGGTGAAGAAGCGGGTGAAGGCCATCACCCTCGCCATCGGAGACGGCGCCAACGATGTCGGGATG
ATCCAGACAGCCCACGTGGGTGTGGGAATCAGTGGGAATGAAGGCATGCAGGCCACCAACAACTCGGATTACGCCATCGCACAGTTTTCC
TACTTAGAGAAGCTTCTGTTGGTTCATGGAGCCTGGAGCTACAACCGGGTGACCAAGTGCATCTTGTACTGCTTCTATAAGAACGTGGTC
CTGTATATTATTGAGCTTTGGTTCGCCTTTGTTAATGGATTTTCTGGGCAGATTTTATTTGAACGTTGGTGCATCGGCCTGTACAATGTG
ATTTTCACCGCTTTGCCGCCCTTCACTCTGGGAATCTTTGAGAGGTCTTGCACTCAGGAGAGCATGCTCAGGTTTCCCCAGCTCTACAAA
ATCACCCAGAATGGCGAAGGCTTCAACACAAAGGTTTTCTGGGGTCACTGCATCAACGCCTTGGTCCACTCCCTCATCCTCTTCTGGTTT
CCCATGAAAGCTCTGGAGCATGATACTGTGTTGACAAGTGGTCATGCTACCGACTATTTATTTGTTGGAAATATTGTTTACACATATGTT
GTTGTTACTGTTTGTCTGAAAGCTGGTTTGGAGACCACAGCTTGGACTAAATTCAGTCATCTGGCTGTCTGGGGAAGCATGCTGACCTGG
CTGGTGTTTTTTGGCATCTACTCGACCATCTGGCCCACCATTCCCATTGCTCCAGATATGAGAGGACAGGCAACTATGGTCCTGAGCTCC
GCACACTTCTGGTTGGGATTATTTCTGGTTCCTACTGCCTGTTTGATTGAAGATGTGGCATGGAGAGCAGCCAAGCACACCTGCAAAAAG
ACATTGCTGGAGGAGGTGCAGGAGCTGGAAACCAAGTCTCGAGTCCTGGGAAAAGCGGTGCTGCGGGATAGCAATGGAAAGAGGCTGAAC
GAGCGCGACCGCCTGATCAAGAGGCTGGGCCGGAAGACGCCCCCGACGCTGTTCCGGGGCAGCTCCCTGCAGCAGGGCGTCCCGCATGGG
TATGCTTTTTCTCAAGAAGAACACGGAGCTGTTAGTCAGGAAGAAGTCATCCGTGCTTATGACACCACCAAAAAGAAATCCAGGAAGAAA
TAAGACATGAATTTTCCTGACTGATCTTAGGAAAGAGATTCAGTTTGTTGCACCCAGTGTTAACACATCTTTGTCAGAGAAGACTGGCGT
CAGCAGCCAAAACACCAGGAAACACATTTCTGTGGCCTTAGCCAAGCAGTTTGTTAGTTACATATTCCCTCGCAAACCTGGAGTGCAGAC
CACAGGGGAAGCTATCTTTGCCCTCCCAACTCGTCTGCAGTGCTTAGCCTAACTTTTGTTTATGTCGTTATGAAGCATTCAACTGTGCTC
TGTGAGGTGTGAAATTAAAAACATTATGTTTCACCAATATTTAAACATCAGTACTAGTTGTCCTGGGAGAAAGGGAAAGGAGTTTTATGT
TGCGTGAGAGGCCCATCCTGTGTAATTGGAGCAGGGCACACTTGCTTCCTGTTGAGTTAACTCAGAGGTTAAGTCCAACGGGCCACATGC
AGACTTCACTGTAGGCAGGTTGCTCTCCTGCTTTGATTCCTGTTTTGTGTGTAAAATTGGCATAAACTTCTTGATTGCAGTGAAATCACA
AAATTCTCTATCGGGGTGGTCAACCTGAGAACATTTATTTGAACCTCTTAGCCACATTTCCAGCAGGGCAAACCAACTGATGCCCTGGAA
GAGTCTTCCGCACCCTCTCCAGGTGCACTCGGCCCAGTCCTGCCGCCGTGTCCAGGCGCCCCTCACCCCCACACCTGCTGCATGGCTGGC
CACACCACTCAGTGCATGGCGGCCGATGGGCAGCCAACCCAAACCCGCGCCTTTCCTTGTTCCACTGCAGACTCAGATACAGATGCGAAA
AATTCCTTCTTCCACCGCCCTTCTCGTTCTGTAAAGAAAGAAAAGAAACATAGCCTTTCTGCATATATTCTAAACGTCTCTCTGCCTCTG
TCTGACATGGGGCCACCCCACAGGTCAGAGTGGTGGTAGAACCCCTTCAGGACTCCCAGCCGTGGTCAGGCTCTGAATACTCCCTTCCCA
ACATCCAGACTGCTGGGCCTTTGGCATCCACTTACATTAGAACCCACGTTTGTTTCAGAGCACATTTTGGACTTTCACTGTTGGGAAATG
AATGAATTTATAACATGCCTGCACAGCGAAGGAACACACCTGTCGCTCTTAGCTCTAGAGTCAGAGGATGAGTAAACCCAGATGCAAGAG
TATAGGACATTGAGTGGGGAGAACAAGACGACCACAGAAGTCCTCAGAAGGAGAAGGAAGGACACGGAGACACTGAGAGGAGGACACAGA
GGAATCGCCACCAGATCTTTGCAGTAGAAACTCTGAAATAGGCCTTGAGACCCAGACAATTGTCATGATCAGCCCAGTGTGTATGAGAGC
TTAAACAAGACCTTCACACACAGTTCTAATTGAAAAGAATTCCAAACATTTCAGGGAAACACCTTTTTAAAAAATATACTGACATGGTTT
CCTTTCTGTATCCCATCAGTGTTAGACACAGGTACCTATCAGAATACGGCATATCCTGAATTATCTAAGACAAGGAAGTGAAGAGCGGAA
TCACTGACTTTCCCAACTGCAGAGTCCCACACTTAAATCTCAACAGAACCTAGATGTCTTCAGGCATGAATGTGAGCACCTGGAGCCCTT
ACTAAACAACCTGCCTGGAGCCCTGTTCTCTGCTCTGGTTGCCAAACCAGATTTTTGGATGGCCTAAATACTTGTGGGCAACTGTTACTG
GTGAAAAATGGGAGTGGAGAGCATGTTTTGGATTTTCACTGTGGGGAAATGAATGAATTTATCACATGACTGTGCAGCGAAGGAGCACAC
CTGTCACTCTTAGCTCTAGAGTCGGAGGATGAGTCAACCCTGTAGGAATGATTGTGCTAAATTAGGAAATAACACTTTAGTGCACTTTGC
TTCCTAACCCTTTTTTGTCAGAAATCTACAACCTACTGGGCATGGAAATGATTTAAAATATGATCTGCATTGACTAAGAAAACTCATCCT
CACTTATGAGGTGACCAGGATGCAGAGAGGGCCTGAGGGGCAGCAGAACAATGCAATTCACAGGTGAGGCTCCAAAAAGGGCCATTTCTT
TCTCCCCAAGGTGCATAGAACATTTTTAAATATCAGAGTACCCAGCAAGACGGAAGGACTGTCATGCAGGAACTCTAACACAAAATGTGC
CTATGACTAACACGACAAACCAAGGTGTATGGTTTCTTTGCACACCCAGAAAGGTGATGGCCAAGATACAGAGGAGAAACGAAAACTGGA
ATTGAATGTGCATTAGGCATCTTAACTATTCATATTTTGTCTCATTTGGGAACTAAGCCTATTTGGAAAGAGTGGATTAGAAATTGAATT
CTTTGTCAAACAGTTAGCTCTGTCTTGAACTTGAAGCCTTCCAAATCAGAATTATGTATTTAAGTGTGTGTTTGTGTTTGTTTGGGGTTT
TTGTTTCTTACATTAGAGTTCATATTTTCTGGGATTTAAGGATACAGGTGTATTTTCCTATTCTCTTGAGAAGTAGACTAAACAATATTT
GCAGTGATGACAGACGCACACAGAAGAAAACATTAGAAGAGATGCCTTTCTATCCTCTCATGTGGTTGAGCATTCTTACAGCCAAATGAC
TAAATTGGCTGTAAATTGGTTTCTAGGAGGAGCAGCTGTCACTACGTGTGATGTATAATATTTAGCCAGGGCCAACTCAGGGGCTGTGTC
ATTTGTCCTATCTTTAAATTGAGGTCAGAGTGTCACACACAACCCCTCCCCTGGGGCAGGGTGGACTGGACTAGGTTGCATACGCTGGCT
GTCAGCTCAGCAAAAATGCCACATGGGGCTTGTCACTCCGCCAGACACTCACTGACTCACGGGCTGGCAGGTCACGCTCGGTTAGCGCTC
CAGGGCCTGACTCTGGATTGAGCTAAACTGGCAGAATCCACTCAGGCCAACCCTTGGTCTACTGCTGTGTACAGACAGCCCAGTCCTGTG
TTGAGTCTCTCTTCTCCTGGATGACCCTGCAAAAGGAAGAGACCAGTTGTACTGTGGGCTTAGTTCTGGGTTTCCACTGCACACTGACAC
GTGCCAGCAAGGGTAGCTGTGGAAAACACGTATCAGGAGAGCAGAGTAGTCTGGATGAATACTCTGTGCTGATCAGAACGGGCTCGGTCA
TAATTTAGGAGTGGAGCTGATGTGTCTGTCCTGCCTCAGTGCAGAATATTCCAGGCTTCTTGACCAGGGTTATGTTCACCCATCTCCCAA
CACACACATGCACACATGAAAACAAAAACATGGTAACTCTTTTGGTTCGGCACACCATACAAAACGTGCTTTGGGGCGAGGAGTGCTGTT
TCTTTTAACACTTGTAGAGGAATATCCTGAGAAGTGAACCTGGGCTTTGGGAGAGCTCAGCTGAGAATTCTGTTGACATTTTCTTTCCCT
TGACAAGGCTTCAGGTTCGTCTCACTATAGGGAGCTGGCTGTGAAAATCAGTAATAACTTGTCAAGAAGCAGTGAAAAATGCGGGGGGGT
GGAAAGAGCCTAGGTAACTAATGTCTTATAATGCATATGTATGTAAATATTACAGGATTTAAGGTTGAATTTTTTAAAAAGAAAGTTATA
GTCTGTAATTTCCATTTGTTATAATAATGACCTTTAATCTTGTCATTTGGAACCATAAAGCATTTTTATCAGGTACCTCTGTTCCAAGGG
ATTTATGTCTTAGACCATAGCTGAATTGAATGTTTGCAAAACACTGCTATAGGATAAGGTGGTCTTTAGTTTTGAACGTGTGAAAGGACT
GCACACTTTTCAGCCAGGGTTTGAGTTACTGCCCAGGGTCATCGTCTCAAAGTAATTCAAGGAGTGATTTAACATCAGCATTTGAAATGT
AGTCTTCATCTCCTGGGATCCATAAAAAAATGTGAACAGGGAAATGGTGGCTAAGCAGAGCCTGAAATAATAACTTGGCAAAGAAATGAG
TTTATCAGGTCGAGTCAAAACATGGCATCCCCTGTTACACTCAAGAAATGTTTTCTTCATGTAAATGTTTATACGGGCATATATAATCAC
AATGGGAACAGTTAAAACCCCCTCCCTTCAAAAAAAGAAAATCTATATCAGTTGGGTTTGGTTTTGGTTCTTCATTGGCTCAAGGCAGTT
AACTGTCTCAGTATAGCCTTCGGGGAGATTTAACCTCATTCTAGCCATTTTTCCATCCTGAAGGCCAAGAAGGACTATTAGAAGGGTTTT
TGAGGGGTTTCGGAGGTGAGGGCCCAAGACCCCCATAATGACATCATTAGGCATTCTTGAAAGGTGTTAACAGACCAGCACGCTCGATGT
GTTGTACCCTTCATTTATTTTTTTTTCTCAGCATCCCAAGTTGTCCATCAGTACATTCCCCTTCACCTTACCTGATCTTCATTTAATGCC
CAGTCTGTAACTAATGTTCTGTTTAAAGCTCTCTTAATTTGTTGGCTATGAGTGATTTGTGAATCTGGGATGTAACCCTGAGTGAGGAGA
AAAGGGCATTGAGCCAGCATAAATCTGAATGGGCAGAAGCCACAAACAAATGGGAGCAGAAAAGAAGGGCGAGCTCCCCCGCGCCGCACC
CCGTGTATAATCCAGTGTTAACCTCTGAGGAACACCTCGGCTCTCCCAACTGAGGAGAGACAAAAGAGGGATTCTTTTTACACCCAGGCT
GGCGCATTTTCAAGTGACAATCTCGGGCTCTAGTTGCCTTTGAGATATCCACTCTGCTCTTTCTCCCAGGCCTCAGACCAAGAAAAACAT
GCTCTCAAGATTAGCCCATAGGCAGTTCTTGTGACCTGGCTGAAGAAAGAAAGGAGACCTGTTTGTTTTAAAAGTCGGGCGCAAAGTGTC
AGGTGGCTTTGATTTATGACAGAAAGAGGAAGAAGAAAGTTGGAGTAATAGCACTATCCAAATAACCCTGCCCAGGAAACTTGGGGGTCA
AGAGAGCTTATCAAGAGCCTTTTATAGGTAAGCTCTTCCGTGTGAAAGAGAAAAGGCCGGAAAGAGGGAGAGAGCCCAGAGAGCAGGCTG
CGAACTCACTTCCAATGGGATTGGAGTCTGTTGTATTCTTAAGAGATAGCCTGATATGTGGTTTATAGGTGAATCAATAAACACCAACAA
CAACAAAAAAAAAAAAAAAAAAAAAGGAAGAAAAGAAAAAAAGGAAACCAGCCCTGTCATGGAATTTCTCTCCTTCCCTGCACAGTAAAG
ACTTTTGGGTTTTCATGGATAAAATCAATGTCAGTACTGAAACTCCTACTCTCCCCTCCCGCCCCACTCTCCCCCGTTGCCCGAGATGGC
CAAGTTCAGGCCTGTGCAATGCCGCTTCCCTCTGAGCCTCCCTCTCAAGGGCCACGCAGGCAGCTGCAGCAGGGCCAGCTGCAGGATGGG
GCTGCCGGTCACTGAATTGTCGTTCAAATGCATCATCTTTGTGGCGTCTTTCTCATGCGAGCAAAGCCACGTGCTCTCCTGTCTGCTGTC
ACATCTGTGCCTGGATTGCTTAAATATTGTTTGTGATGGGGAGGTTTTAATCTGGTGATGCAGAGGGAAGCAGGGCTGTGGGGGCACGTT
TAATTGGCTCCCAGCAGCGTGGGGGGTGCTTCTATGGTGTGTGGGGTTTTTTGTTGCCTCCCTCTAGAAGTGTTACCGTTTTCACGTCCT
ATTAATGTCCTCTGGTTGTTAAATTACAGCAGCACATTACAGTGCACTGGGTTCCCTCCTGGAGTGAATACAAACGGAGGGCATCTACTT
GTATTTTTAGAAGTTTTGGGAGAATTTAGTGATTTGTGGCTTTGATCAATCCTGTTGACTGGTGTATGTCTGCGCAAACCTGTTTCAAAT

>74793_74793_2_RNF13-ATP8A2_RNF13_chr3_149570383_ENST00000344229_ATP8A2_chr13_26273311_ENST00000381655_length(amino acids)=516AA_BP=65
MLLSIGMLMLSATQVYTILTVQLFAFLNLLPVEADILAYNFENASQTFDDLPARFGYRLPAEGLKATRAAITQHCTDLGNLLGKENDVAL
IIDGHTLKYALSFEVRRSFLDLALSCKAVICCRVSPLQKSEIVDVVKKRVKAITLAIGDGANDVGMIQTAHVGVGISGNEGMQATNNSDY
AIAQFSYLEKLLLVHGAWSYNRVTKCILYCFYKNVVLYIIELWFAFVNGFSGQILFERWCIGLYNVIFTALPPFTLGIFERSCTQESMLR
FPQLYKITQNGEGFNTKVFWGHCINALVHSLILFWFPMKALEHDTVLTSGHATDYLFVGNIVYTYVVVTVCLKAGLETTAWTKFSHLAVW
GSMLTWLVFFGIYSTIWPTIPIAPDMRGQATMVLSSAHFWLGLFLVPTACLIEDVAWRAAKHTCKKTLLEEVQELETKSRVLGKAVLRDS

--------------------------------------------------------------
>74793_74793_3_RNF13-ATP8A2_RNF13_chr3_149570383_ENST00000392894_ATP8A2_chr13_26273311_ENST00000255283_length(transcript)=2394nt_BP=857nt
CTCTTTAGTAGGTCGGGTGAGTGTAGTGTGCAGGGAAGAGACGCGTCAGCGCCAGGGCCAGGCCCGCCCGGGGGCAGCCCGGCAGCCGAA
TCTTGGGCTACTCTGTCCCAACAGCCGGAGCAGATCAGACCGACCGGCCCTGCCCGCTCGGTCCCGCGCCCTCCAGACCCTACGGTCTCC
GTTTCTAGGGGCACATGGTTAGCGGCAGGCGCCCACAGCCAATCCACTTTGCCAGCCTGCCCCTTCCTCTGCCAAGAGCAGCTTCTTCAG
CCGCGCTCCAGTTCCGCAGACGCCTGCCCCACCCTGCTCTTCCCTTCCAGGGAAGACGGATCACGCGGCCAAGAACGAGACTCGCAAACT
GGGCATTTCTCCGAGCCGGGCTAGAGCAAGTAGCGAGACTCCGCGTGAGAGTGGGAAAGAGCCTTAACAGGCAACCATGTTGCCCAGTGG
GTTTTCTGTGCCTTTGGGTGCGGACCAATGAGGCGCGTGGGGCGGGACTTCCGCTTCGCCTAGGTGTTGTCGTCCCTGCTAGTACTCCGG
GCTGTGGGGGTCGGTGCGGATATTCAGTCATGAAATCAGGGTAGGGACTTCTCCCGCAGCGACGCGGCTGGCAAGACTGTTTGTGTTGCG
GGGGCCGGACTTCAAGGTGATTTTACAACGAGATGCTGCTCTCCATAGGGATGCTCATGCTGTCAGCCACACAAGTCTACACCATCTTGA
CTGTCCAGCTCTTTGCATTCTTAAACCTACTGCCTGTAGAAGCAGACATTTTAGCATATAACTTTGAAAATGCATCTCAGACATTTGATG
ACCTCCCTGCAAGATTTGGTTATAGACTTCCAGCTGAAGGTTTAAAGGCCACAAGGGCAGCCATTACTCAGCACTGCACTGACCTTGGGA
ATTTGCTGGGCAAGGAAAATGACGTGGCCCTGATCATCGATGGCCACACCCTGAAGTACGCGCTCTCCTTCGAAGTCCGGAGGAGTTTCC
TGGATTTGGCACTCTCGTGCAAAGCGGTCATATGCTGCAGAGTGTCTCCTCTGCAGAAGTCTGAGATAGTGGATGTGGTGAAGAAGCGGG
TGAAGGCCATCACCCTCGCCATCGGAGACGGCGCCAACGATGTCGGGATGATCCAGACAGCCCACGTGGGTGTGGGAATCAGTGGGAATG
AAGGCATGCAGGCCACCAACAACTCGGATTACGCCATCGCACAGTTTTCCTACTTAGAGAAGCTTCTGTTGGTTCATGGAGCCTGGAGCT
ACAACCGGGTGACCAAGTGCATCTTGTACTGCTTCTATAAGAACGTGGTCCTGTATATTATTGAGATTTTCACCGCTTTGCCGCCCTTCA
CTCTGGGAATCTTTGAGAGGTCTTGCACTCAGGAGAGCATGCTCAGGTTTCCCCAGCTCTACAAAATCACCCAGAATGGCGAAGGCTTCA
ACACAAAGGTTTTCTGGGGTCACTGCATCAACGCCTTGGTCCACTCCCTCATCCTCTTCTGGTTTCCCATGAAAGCTCTGGAGCATGATA
CTGTGTTGACAAGTGGTCATGCTACCGACTATTTATTTGTTGGAAATATTGTTTACACATATGTTGTTGTTACTGTTTGTCTGAAAGCTG
GTTTGGAGACCACAGCTTGGACTAAATTCAGTCATCTGGCTGTCTGGGGAAGCATGCTGACCTGGCTGGTGTTTTTTGGCATCTACTCGA
CCATCTGGCCCACCATTCCCATTGCTCCAGATATGAGAGGACAGGCAACTATGGTCCTGAGCTCCGCACACTTCTGGTTGGGATTATTTC
TGGTTCCTACTGCCTGTTTGATTGAAGATGTGGCATGGAGAGCAGCCAAGCACACCTGCAAAAAGACATTGCTGGAGGAGGTGCAGGAGC
TGGAAACCAAGTCTCGAGTCCTGGGAAAAGCGGTGCTGCGGGATAGCAATGGAAAGAGGCTGAACGAGCGCGACCGCCTGATCAAGAGGC
TGGGCCGGAAGACGCCCCCGACGCTGTTCCGGGGCAGCTCCCTGCAGCAGGGCGTCCCGCATGGGTATGCTTTTTCTCAAGAAGAACACG
GAGCTGTTAGTCAGGAAGAAGTCATCCGTGCTTATGACACCACCAAAAAGAAATCCAGGAAGAAATAAGACATGAATTTTCCTGACTGAT
CTTAGGAAAGAGATTCAGTTTGTTGCACCCAGTGTTAACACATCTTTGTCAGAGAAGACTGGCGTCAGCAGCCAAAACACCAGGAAACAC
ATTTCTGTGGCCTTAGCCAAGCAGTTTGTTAGTTACATATTCCCTCGCAAACCTGGAGTGCAGACCACAGGGGAAGCTATCTTTGCCCTC

>74793_74793_3_RNF13-ATP8A2_RNF13_chr3_149570383_ENST00000392894_ATP8A2_chr13_26273311_ENST00000255283_length(amino acids)=491AA_BP=65
MLLSIGMLMLSATQVYTILTVQLFAFLNLLPVEADILAYNFENASQTFDDLPARFGYRLPAEGLKATRAAITQHCTDLGNLLGKENDVAL
IIDGHTLKYALSFEVRRSFLDLALSCKAVICCRVSPLQKSEIVDVVKKRVKAITLAIGDGANDVGMIQTAHVGVGISGNEGMQATNNSDY
AIAQFSYLEKLLLVHGAWSYNRVTKCILYCFYKNVVLYIIEIFTALPPFTLGIFERSCTQESMLRFPQLYKITQNGEGFNTKVFWGHCIN
ALVHSLILFWFPMKALEHDTVLTSGHATDYLFVGNIVYTYVVVTVCLKAGLETTAWTKFSHLAVWGSMLTWLVFFGIYSTIWPTIPIAPD
MRGQATMVLSSAHFWLGLFLVPTACLIEDVAWRAAKHTCKKTLLEEVQELETKSRVLGKAVLRDSNGKRLNERDRLIKRLGRKTPPTLFR

--------------------------------------------------------------
>74793_74793_4_RNF13-ATP8A2_RNF13_chr3_149570383_ENST00000392894_ATP8A2_chr13_26273311_ENST00000381655_length(transcript)=8079nt_BP=857nt
CTCTTTAGTAGGTCGGGTGAGTGTAGTGTGCAGGGAAGAGACGCGTCAGCGCCAGGGCCAGGCCCGCCCGGGGGCAGCCCGGCAGCCGAA
TCTTGGGCTACTCTGTCCCAACAGCCGGAGCAGATCAGACCGACCGGCCCTGCCCGCTCGGTCCCGCGCCCTCCAGACCCTACGGTCTCC
GTTTCTAGGGGCACATGGTTAGCGGCAGGCGCCCACAGCCAATCCACTTTGCCAGCCTGCCCCTTCCTCTGCCAAGAGCAGCTTCTTCAG
CCGCGCTCCAGTTCCGCAGACGCCTGCCCCACCCTGCTCTTCCCTTCCAGGGAAGACGGATCACGCGGCCAAGAACGAGACTCGCAAACT
GGGCATTTCTCCGAGCCGGGCTAGAGCAAGTAGCGAGACTCCGCGTGAGAGTGGGAAAGAGCCTTAACAGGCAACCATGTTGCCCAGTGG
GTTTTCTGTGCCTTTGGGTGCGGACCAATGAGGCGCGTGGGGCGGGACTTCCGCTTCGCCTAGGTGTTGTCGTCCCTGCTAGTACTCCGG
GCTGTGGGGGTCGGTGCGGATATTCAGTCATGAAATCAGGGTAGGGACTTCTCCCGCAGCGACGCGGCTGGCAAGACTGTTTGTGTTGCG
GGGGCCGGACTTCAAGGTGATTTTACAACGAGATGCTGCTCTCCATAGGGATGCTCATGCTGTCAGCCACACAAGTCTACACCATCTTGA
CTGTCCAGCTCTTTGCATTCTTAAACCTACTGCCTGTAGAAGCAGACATTTTAGCATATAACTTTGAAAATGCATCTCAGACATTTGATG
ACCTCCCTGCAAGATTTGGTTATAGACTTCCAGCTGAAGGTTTAAAGGCCACAAGGGCAGCCATTACTCAGCACTGCACTGACCTTGGGA
ATTTGCTGGGCAAGGAAAATGACGTGGCCCTGATCATCGATGGCCACACCCTGAAGTACGCGCTCTCCTTCGAAGTCCGGAGGAGTTTCC
TGGATTTGGCACTCTCGTGCAAAGCGGTCATATGCTGCAGAGTGTCTCCTCTGCAGAAGTCTGAGATAGTGGATGTGGTGAAGAAGCGGG
TGAAGGCCATCACCCTCGCCATCGGAGACGGCGCCAACGATGTCGGGATGATCCAGACAGCCCACGTGGGTGTGGGAATCAGTGGGAATG
AAGGCATGCAGGCCACCAACAACTCGGATTACGCCATCGCACAGTTTTCCTACTTAGAGAAGCTTCTGTTGGTTCATGGAGCCTGGAGCT
ACAACCGGGTGACCAAGTGCATCTTGTACTGCTTCTATAAGAACGTGGTCCTGTATATTATTGAGCTTTGGTTCGCCTTTGTTAATGGAT
TTTCTGGGCAGATTTTATTTGAACGTTGGTGCATCGGCCTGTACAATGTGATTTTCACCGCTTTGCCGCCCTTCACTCTGGGAATCTTTG
AGAGGTCTTGCACTCAGGAGAGCATGCTCAGGTTTCCCCAGCTCTACAAAATCACCCAGAATGGCGAAGGCTTCAACACAAAGGTTTTCT
GGGGTCACTGCATCAACGCCTTGGTCCACTCCCTCATCCTCTTCTGGTTTCCCATGAAAGCTCTGGAGCATGATACTGTGTTGACAAGTG
GTCATGCTACCGACTATTTATTTGTTGGAAATATTGTTTACACATATGTTGTTGTTACTGTTTGTCTGAAAGCTGGTTTGGAGACCACAG
CTTGGACTAAATTCAGTCATCTGGCTGTCTGGGGAAGCATGCTGACCTGGCTGGTGTTTTTTGGCATCTACTCGACCATCTGGCCCACCA
TTCCCATTGCTCCAGATATGAGAGGACAGGCAACTATGGTCCTGAGCTCCGCACACTTCTGGTTGGGATTATTTCTGGTTCCTACTGCCT
GTTTGATTGAAGATGTGGCATGGAGAGCAGCCAAGCACACCTGCAAAAAGACATTGCTGGAGGAGGTGCAGGAGCTGGAAACCAAGTCTC
GAGTCCTGGGAAAAGCGGTGCTGCGGGATAGCAATGGAAAGAGGCTGAACGAGCGCGACCGCCTGATCAAGAGGCTGGGCCGGAAGACGC
CCCCGACGCTGTTCCGGGGCAGCTCCCTGCAGCAGGGCGTCCCGCATGGGTATGCTTTTTCTCAAGAAGAACACGGAGCTGTTAGTCAGG
AAGAAGTCATCCGTGCTTATGACACCACCAAAAAGAAATCCAGGAAGAAATAAGACATGAATTTTCCTGACTGATCTTAGGAAAGAGATT
CAGTTTGTTGCACCCAGTGTTAACACATCTTTGTCAGAGAAGACTGGCGTCAGCAGCCAAAACACCAGGAAACACATTTCTGTGGCCTTA
GCCAAGCAGTTTGTTAGTTACATATTCCCTCGCAAACCTGGAGTGCAGACCACAGGGGAAGCTATCTTTGCCCTCCCAACTCGTCTGCAG
TGCTTAGCCTAACTTTTGTTTATGTCGTTATGAAGCATTCAACTGTGCTCTGTGAGGTGTGAAATTAAAAACATTATGTTTCACCAATAT
TTAAACATCAGTACTAGTTGTCCTGGGAGAAAGGGAAAGGAGTTTTATGTTGCGTGAGAGGCCCATCCTGTGTAATTGGAGCAGGGCACA
CTTGCTTCCTGTTGAGTTAACTCAGAGGTTAAGTCCAACGGGCCACATGCAGACTTCACTGTAGGCAGGTTGCTCTCCTGCTTTGATTCC
TGTTTTGTGTGTAAAATTGGCATAAACTTCTTGATTGCAGTGAAATCACAAAATTCTCTATCGGGGTGGTCAACCTGAGAACATTTATTT
GAACCTCTTAGCCACATTTCCAGCAGGGCAAACCAACTGATGCCCTGGAAGAGTCTTCCGCACCCTCTCCAGGTGCACTCGGCCCAGTCC
TGCCGCCGTGTCCAGGCGCCCCTCACCCCCACACCTGCTGCATGGCTGGCCACACCACTCAGTGCATGGCGGCCGATGGGCAGCCAACCC
AAACCCGCGCCTTTCCTTGTTCCACTGCAGACTCAGATACAGATGCGAAAAATTCCTTCTTCCACCGCCCTTCTCGTTCTGTAAAGAAAG
AAAAGAAACATAGCCTTTCTGCATATATTCTAAACGTCTCTCTGCCTCTGTCTGACATGGGGCCACCCCACAGGTCAGAGTGGTGGTAGA
ACCCCTTCAGGACTCCCAGCCGTGGTCAGGCTCTGAATACTCCCTTCCCAACATCCAGACTGCTGGGCCTTTGGCATCCACTTACATTAG
AACCCACGTTTGTTTCAGAGCACATTTTGGACTTTCACTGTTGGGAAATGAATGAATTTATAACATGCCTGCACAGCGAAGGAACACACC
TGTCGCTCTTAGCTCTAGAGTCAGAGGATGAGTAAACCCAGATGCAAGAGTATAGGACATTGAGTGGGGAGAACAAGACGACCACAGAAG
TCCTCAGAAGGAGAAGGAAGGACACGGAGACACTGAGAGGAGGACACAGAGGAATCGCCACCAGATCTTTGCAGTAGAAACTCTGAAATA
GGCCTTGAGACCCAGACAATTGTCATGATCAGCCCAGTGTGTATGAGAGCTTAAACAAGACCTTCACACACAGTTCTAATTGAAAAGAAT
TCCAAACATTTCAGGGAAACACCTTTTTAAAAAATATACTGACATGGTTTCCTTTCTGTATCCCATCAGTGTTAGACACAGGTACCTATC
AGAATACGGCATATCCTGAATTATCTAAGACAAGGAAGTGAAGAGCGGAATCACTGACTTTCCCAACTGCAGAGTCCCACACTTAAATCT
CAACAGAACCTAGATGTCTTCAGGCATGAATGTGAGCACCTGGAGCCCTTACTAAACAACCTGCCTGGAGCCCTGTTCTCTGCTCTGGTT
GCCAAACCAGATTTTTGGATGGCCTAAATACTTGTGGGCAACTGTTACTGGTGAAAAATGGGAGTGGAGAGCATGTTTTGGATTTTCACT
GTGGGGAAATGAATGAATTTATCACATGACTGTGCAGCGAAGGAGCACACCTGTCACTCTTAGCTCTAGAGTCGGAGGATGAGTCAACCC
TGTAGGAATGATTGTGCTAAATTAGGAAATAACACTTTAGTGCACTTTGCTTCCTAACCCTTTTTTGTCAGAAATCTACAACCTACTGGG
CATGGAAATGATTTAAAATATGATCTGCATTGACTAAGAAAACTCATCCTCACTTATGAGGTGACCAGGATGCAGAGAGGGCCTGAGGGG
CAGCAGAACAATGCAATTCACAGGTGAGGCTCCAAAAAGGGCCATTTCTTTCTCCCCAAGGTGCATAGAACATTTTTAAATATCAGAGTA
CCCAGCAAGACGGAAGGACTGTCATGCAGGAACTCTAACACAAAATGTGCCTATGACTAACACGACAAACCAAGGTGTATGGTTTCTTTG
CACACCCAGAAAGGTGATGGCCAAGATACAGAGGAGAAACGAAAACTGGAATTGAATGTGCATTAGGCATCTTAACTATTCATATTTTGT
CTCATTTGGGAACTAAGCCTATTTGGAAAGAGTGGATTAGAAATTGAATTCTTTGTCAAACAGTTAGCTCTGTCTTGAACTTGAAGCCTT
CCAAATCAGAATTATGTATTTAAGTGTGTGTTTGTGTTTGTTTGGGGTTTTTGTTTCTTACATTAGAGTTCATATTTTCTGGGATTTAAG
GATACAGGTGTATTTTCCTATTCTCTTGAGAAGTAGACTAAACAATATTTGCAGTGATGACAGACGCACACAGAAGAAAACATTAGAAGA
GATGCCTTTCTATCCTCTCATGTGGTTGAGCATTCTTACAGCCAAATGACTAAATTGGCTGTAAATTGGTTTCTAGGAGGAGCAGCTGTC
ACTACGTGTGATGTATAATATTTAGCCAGGGCCAACTCAGGGGCTGTGTCATTTGTCCTATCTTTAAATTGAGGTCAGAGTGTCACACAC
AACCCCTCCCCTGGGGCAGGGTGGACTGGACTAGGTTGCATACGCTGGCTGTCAGCTCAGCAAAAATGCCACATGGGGCTTGTCACTCCG
CCAGACACTCACTGACTCACGGGCTGGCAGGTCACGCTCGGTTAGCGCTCCAGGGCCTGACTCTGGATTGAGCTAAACTGGCAGAATCCA
CTCAGGCCAACCCTTGGTCTACTGCTGTGTACAGACAGCCCAGTCCTGTGTTGAGTCTCTCTTCTCCTGGATGACCCTGCAAAAGGAAGA
GACCAGTTGTACTGTGGGCTTAGTTCTGGGTTTCCACTGCACACTGACACGTGCCAGCAAGGGTAGCTGTGGAAAACACGTATCAGGAGA
GCAGAGTAGTCTGGATGAATACTCTGTGCTGATCAGAACGGGCTCGGTCATAATTTAGGAGTGGAGCTGATGTGTCTGTCCTGCCTCAGT
GCAGAATATTCCAGGCTTCTTGACCAGGGTTATGTTCACCCATCTCCCAACACACACATGCACACATGAAAACAAAAACATGGTAACTCT
TTTGGTTCGGCACACCATACAAAACGTGCTTTGGGGCGAGGAGTGCTGTTTCTTTTAACACTTGTAGAGGAATATCCTGAGAAGTGAACC
TGGGCTTTGGGAGAGCTCAGCTGAGAATTCTGTTGACATTTTCTTTCCCTTGACAAGGCTTCAGGTTCGTCTCACTATAGGGAGCTGGCT
GTGAAAATCAGTAATAACTTGTCAAGAAGCAGTGAAAAATGCGGGGGGGTGGAAAGAGCCTAGGTAACTAATGTCTTATAATGCATATGT
ATGTAAATATTACAGGATTTAAGGTTGAATTTTTTAAAAAGAAAGTTATAGTCTGTAATTTCCATTTGTTATAATAATGACCTTTAATCT
TGTCATTTGGAACCATAAAGCATTTTTATCAGGTACCTCTGTTCCAAGGGATTTATGTCTTAGACCATAGCTGAATTGAATGTTTGCAAA
ACACTGCTATAGGATAAGGTGGTCTTTAGTTTTGAACGTGTGAAAGGACTGCACACTTTTCAGCCAGGGTTTGAGTTACTGCCCAGGGTC
ATCGTCTCAAAGTAATTCAAGGAGTGATTTAACATCAGCATTTGAAATGTAGTCTTCATCTCCTGGGATCCATAAAAAAATGTGAACAGG
GAAATGGTGGCTAAGCAGAGCCTGAAATAATAACTTGGCAAAGAAATGAGTTTATCAGGTCGAGTCAAAACATGGCATCCCCTGTTACAC
TCAAGAAATGTTTTCTTCATGTAAATGTTTATACGGGCATATATAATCACAATGGGAACAGTTAAAACCCCCTCCCTTCAAAAAAAGAAA
ATCTATATCAGTTGGGTTTGGTTTTGGTTCTTCATTGGCTCAAGGCAGTTAACTGTCTCAGTATAGCCTTCGGGGAGATTTAACCTCATT
CTAGCCATTTTTCCATCCTGAAGGCCAAGAAGGACTATTAGAAGGGTTTTTGAGGGGTTTCGGAGGTGAGGGCCCAAGACCCCCATAATG
ACATCATTAGGCATTCTTGAAAGGTGTTAACAGACCAGCACGCTCGATGTGTTGTACCCTTCATTTATTTTTTTTTCTCAGCATCCCAAG
TTGTCCATCAGTACATTCCCCTTCACCTTACCTGATCTTCATTTAATGCCCAGTCTGTAACTAATGTTCTGTTTAAAGCTCTCTTAATTT
GTTGGCTATGAGTGATTTGTGAATCTGGGATGTAACCCTGAGTGAGGAGAAAAGGGCATTGAGCCAGCATAAATCTGAATGGGCAGAAGC
CACAAACAAATGGGAGCAGAAAAGAAGGGCGAGCTCCCCCGCGCCGCACCCCGTGTATAATCCAGTGTTAACCTCTGAGGAACACCTCGG
CTCTCCCAACTGAGGAGAGACAAAAGAGGGATTCTTTTTACACCCAGGCTGGCGCATTTTCAAGTGACAATCTCGGGCTCTAGTTGCCTT
TGAGATATCCACTCTGCTCTTTCTCCCAGGCCTCAGACCAAGAAAAACATGCTCTCAAGATTAGCCCATAGGCAGTTCTTGTGACCTGGC
TGAAGAAAGAAAGGAGACCTGTTTGTTTTAAAAGTCGGGCGCAAAGTGTCAGGTGGCTTTGATTTATGACAGAAAGAGGAAGAAGAAAGT
TGGAGTAATAGCACTATCCAAATAACCCTGCCCAGGAAACTTGGGGGTCAAGAGAGCTTATCAAGAGCCTTTTATAGGTAAGCTCTTCCG
TGTGAAAGAGAAAAGGCCGGAAAGAGGGAGAGAGCCCAGAGAGCAGGCTGCGAACTCACTTCCAATGGGATTGGAGTCTGTTGTATTCTT
AAGAGATAGCCTGATATGTGGTTTATAGGTGAATCAATAAACACCAACAACAACAAAAAAAAAAAAAAAAAAAAAGGAAGAAAAGAAAAA
AAGGAAACCAGCCCTGTCATGGAATTTCTCTCCTTCCCTGCACAGTAAAGACTTTTGGGTTTTCATGGATAAAATCAATGTCAGTACTGA
AACTCCTACTCTCCCCTCCCGCCCCACTCTCCCCCGTTGCCCGAGATGGCCAAGTTCAGGCCTGTGCAATGCCGCTTCCCTCTGAGCCTC
CCTCTCAAGGGCCACGCAGGCAGCTGCAGCAGGGCCAGCTGCAGGATGGGGCTGCCGGTCACTGAATTGTCGTTCAAATGCATCATCTTT
GTGGCGTCTTTCTCATGCGAGCAAAGCCACGTGCTCTCCTGTCTGCTGTCACATCTGTGCCTGGATTGCTTAAATATTGTTTGTGATGGG
GAGGTTTTAATCTGGTGATGCAGAGGGAAGCAGGGCTGTGGGGGCACGTTTAATTGGCTCCCAGCAGCGTGGGGGGTGCTTCTATGGTGT
GTGGGGTTTTTTGTTGCCTCCCTCTAGAAGTGTTACCGTTTTCACGTCCTATTAATGTCCTCTGGTTGTTAAATTACAGCAGCACATTAC
AGTGCACTGGGTTCCCTCCTGGAGTGAATACAAACGGAGGGCATCTACTTGTATTTTTAGAAGTTTTGGGAGAATTTAGTGATTTGTGGC

>74793_74793_4_RNF13-ATP8A2_RNF13_chr3_149570383_ENST00000392894_ATP8A2_chr13_26273311_ENST00000381655_length(amino acids)=516AA_BP=65
MLLSIGMLMLSATQVYTILTVQLFAFLNLLPVEADILAYNFENASQTFDDLPARFGYRLPAEGLKATRAAITQHCTDLGNLLGKENDVAL
IIDGHTLKYALSFEVRRSFLDLALSCKAVICCRVSPLQKSEIVDVVKKRVKAITLAIGDGANDVGMIQTAHVGVGISGNEGMQATNNSDY
AIAQFSYLEKLLLVHGAWSYNRVTKCILYCFYKNVVLYIIELWFAFVNGFSGQILFERWCIGLYNVIFTALPPFTLGIFERSCTQESMLR
FPQLYKITQNGEGFNTKVFWGHCINALVHSLILFWFPMKALEHDTVLTSGHATDYLFVGNIVYTYVVVTVCLKAGLETTAWTKFSHLAVW
GSMLTWLVFFGIYSTIWPTIPIAPDMRGQATMVLSSAHFWLGLFLVPTACLIEDVAWRAAKHTCKKTLLEEVQELETKSRVLGKAVLRDS

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Fusion Gene PPI Analysis for RNF13-ATP8A2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RNF13-ATP8A2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RNF13-ATP8A2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource