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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RNF13-LIMCH1 (FusionGDB2 ID:74798)

Fusion Gene Summary for RNF13-LIMCH1

check button Fusion gene summary
Fusion gene informationFusion gene name: RNF13-LIMCH1
Fusion gene ID: 74798
HgeneTgene
Gene symbol

RNF13

LIMCH1

Gene ID

11342

22998

Gene namering finger protein 13LIM and calponin homology domains 1
SynonymsEIEE73|RZFLIMCH1A|LMO7B
Cytomap

3q25.1

4p13

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase RNF13RING zinc finger proteinRING-type E3 ubiquitin transferase RNF13LIM and calponin homology domains-containing protein 1
Modification date2020031320200313
UniProtAcc.

Q9UPQ0

Ensembl transtripts involved in fusion geneENST00000344229, ENST00000392894, 
ENST00000361785, 		ENST00000313860, 
ENST00000381753, ENST00000396595, 
ENST00000503057, ENST00000508501, 
ENST00000509277, ENST00000509454, 
ENST00000509638, ENST00000511496, 
ENST00000512632, ENST00000512820, 
ENST00000512946, ENST00000514096, 
ENST00000515785, ENST00000513024, 
Fusion gene scores* DoF score10 X 9 X 7=63018 X 19 X 9=3078
# samples 1319
** MAII scorelog2(13/630*10)=-2.27684020535882
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/3078*10)=-4.01792190799726
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RNF13 [Title/Abstract] AND LIMCH1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRNF13(149589944)-LIMCH1(41652408), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across RNF13 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LIMCH1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ADA317546RNF13chr3

149589944

+LIMCH1chr4

41652408

+


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Fusion Gene ORF analysis for RNF13-LIMCH1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000344229ENST00000313860RNF13chr3

149589944

+LIMCH1chr4

41652408

+
5CDS-intronENST00000344229ENST00000381753RNF13chr3

149589944

+LIMCH1chr4

41652408

+
5CDS-intronENST00000344229ENST00000396595RNF13chr3

149589944

+LIMCH1chr4

41652408

+
5CDS-intronENST00000344229ENST00000503057RNF13chr3

149589944

+LIMCH1chr4

41652408

+
5CDS-intronENST00000344229ENST00000508501RNF13chr3

149589944

+LIMCH1chr4

41652408

+
5CDS-intronENST00000344229ENST00000509277RNF13chr3

149589944

+LIMCH1chr4

41652408

+
5CDS-intronENST00000344229ENST00000509454RNF13chr3

149589944

+LIMCH1chr4

41652408

+
5CDS-intronENST00000344229ENST00000509638RNF13chr3

149589944

+LIMCH1chr4

41652408

+
5CDS-intronENST00000344229ENST00000511496RNF13chr3

149589944

+LIMCH1chr4

41652408

+
5CDS-intronENST00000344229ENST00000512632RNF13chr3

149589944

+LIMCH1chr4

41652408

+
5CDS-intronENST00000344229ENST00000512820RNF13chr3

149589944

+LIMCH1chr4

41652408

+
5CDS-intronENST00000344229ENST00000512946RNF13chr3

149589944

+LIMCH1chr4

41652408

+
5CDS-intronENST00000344229ENST00000514096RNF13chr3

149589944

+LIMCH1chr4

41652408

+
5CDS-intronENST00000344229ENST00000515785RNF13chr3

149589944

+LIMCH1chr4

41652408

+
5CDS-intronENST00000392894ENST00000313860RNF13chr3

149589944

+LIMCH1chr4

41652408

+
5CDS-intronENST00000392894ENST00000381753RNF13chr3

149589944

+LIMCH1chr4

41652408

+
5CDS-intronENST00000392894ENST00000396595RNF13chr3

149589944

+LIMCH1chr4

41652408

+
5CDS-intronENST00000392894ENST00000503057RNF13chr3

149589944

+LIMCH1chr4

41652408

+
5CDS-intronENST00000392894ENST00000508501RNF13chr3

149589944

+LIMCH1chr4

41652408

+
5CDS-intronENST00000392894ENST00000509277RNF13chr3

149589944

+LIMCH1chr4

41652408

+
5CDS-intronENST00000392894ENST00000509454RNF13chr3

149589944

+LIMCH1chr4

41652408

+
5CDS-intronENST00000392894ENST00000509638RNF13chr3

149589944

+LIMCH1chr4

41652408

+
5CDS-intronENST00000392894ENST00000511496RNF13chr3

149589944

+LIMCH1chr4

41652408

+
5CDS-intronENST00000392894ENST00000512632RNF13chr3

149589944

+LIMCH1chr4

41652408

+
5CDS-intronENST00000392894ENST00000512820RNF13chr3

149589944

+LIMCH1chr4

41652408

+
5CDS-intronENST00000392894ENST00000512946RNF13chr3

149589944

+LIMCH1chr4

41652408

+
5CDS-intronENST00000392894ENST00000514096RNF13chr3

149589944

+LIMCH1chr4

41652408

+
5CDS-intronENST00000392894ENST00000515785RNF13chr3

149589944

+LIMCH1chr4

41652408

+
5UTR-3CDSENST00000361785ENST00000513024RNF13chr3

149589944

+LIMCH1chr4

41652408

+
5UTR-intronENST00000361785ENST00000313860RNF13chr3

149589944

+LIMCH1chr4

41652408

+
5UTR-intronENST00000361785ENST00000381753RNF13chr3

149589944

+LIMCH1chr4

41652408

+
5UTR-intronENST00000361785ENST00000396595RNF13chr3

149589944

+LIMCH1chr4

41652408

+
5UTR-intronENST00000361785ENST00000503057RNF13chr3

149589944

+LIMCH1chr4

41652408

+
5UTR-intronENST00000361785ENST00000508501RNF13chr3

149589944

+LIMCH1chr4

41652408

+
5UTR-intronENST00000361785ENST00000509277RNF13chr3

149589944

+LIMCH1chr4

41652408

+
5UTR-intronENST00000361785ENST00000509454RNF13chr3

149589944

+LIMCH1chr4

41652408

+
5UTR-intronENST00000361785ENST00000509638RNF13chr3

149589944

+LIMCH1chr4

41652408

+
5UTR-intronENST00000361785ENST00000511496RNF13chr3

149589944

+LIMCH1chr4

41652408

+
5UTR-intronENST00000361785ENST00000512632RNF13chr3

149589944

+LIMCH1chr4

41652408

+
5UTR-intronENST00000361785ENST00000512820RNF13chr3

149589944

+LIMCH1chr4

41652408

+
5UTR-intronENST00000361785ENST00000512946RNF13chr3

149589944

+LIMCH1chr4

41652408

+
5UTR-intronENST00000361785ENST00000514096RNF13chr3

149589944

+LIMCH1chr4

41652408

+
5UTR-intronENST00000361785ENST00000515785RNF13chr3

149589944

+LIMCH1chr4

41652408

+
In-frameENST00000344229ENST00000513024RNF13chr3

149589944

+LIMCH1chr4

41652408

+
In-frameENST00000392894ENST00000513024RNF13chr3

149589944

+LIMCH1chr4

41652408

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000392894RNF13chr3149589944+ENST00000513024LIMCH1chr441652408+43829836622563633
ENST00000344229RNF13chr3149589944+ENST00000513024LIMCH1chr441652408+442210237022603633

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000392894ENST00000513024RNF13chr3149589944+LIMCH1chr441652408+0.0010668690.99893314
ENST00000344229ENST00000513024RNF13chr3149589944+LIMCH1chr441652408+0.0011900030.99881005

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Fusion Genomic Features for RNF13-LIMCH1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RNF13chr3149589941+LIMCH1chr441652409+0.0013581080.9986419
RNF13chr3149589941+LIMCH1chr441652409+0.0013581080.9986419

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for RNF13-LIMCH1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:149589944/chr4:41652408)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.LIMCH1

Q9UPQ0

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLIMCH1chr3:149589944chr4:41652408ENST000003138601127782_8235551084.0Coiled coilOntology_term=ECO:0000255
TgeneLIMCH1chr3:149589944chr4:41652408ENST00000381753520782_823389891.0Coiled coilOntology_term=ECO:0000255
TgeneLIMCH1chr3:149589944chr4:41652408ENST00000396595621782_823401903.0Coiled coilOntology_term=ECO:0000255
TgeneLIMCH1chr3:149589944chr4:41652408ENST000005085011126782_8235551057.0Coiled coilOntology_term=ECO:0000255
TgeneLIMCH1chr3:149589944chr4:41652408ENST00000511496823782_823396898.0Coiled coilOntology_term=ECO:0000255
TgeneLIMCH1chr3:149589944chr4:41652408ENST000005128201026782_8235431070.0Coiled coilOntology_term=ECO:0000255
TgeneLIMCH1chr3:149589944chr4:41652408ENST000005129461126782_8235551058.0Coiled coilOntology_term=ECO:0000255
TgeneLIMCH1chr3:149589944chr4:41652408ENST000005130241026782_823384911.0Coiled coilOntology_term=ECO:0000255
TgeneLIMCH1chr3:149589944chr4:41652408ENST0000031386011271011_10775551084.0DomainLIM zinc-binding
TgeneLIMCH1chr3:149589944chr4:41652408ENST000003817535201011_1077389891.0DomainLIM zinc-binding
TgeneLIMCH1chr3:149589944chr4:41652408ENST000003965956211011_1077401903.0DomainLIM zinc-binding
TgeneLIMCH1chr3:149589944chr4:41652408ENST0000050850111261011_10775551057.0DomainLIM zinc-binding
TgeneLIMCH1chr3:149589944chr4:41652408ENST000005114968231011_1077396898.0DomainLIM zinc-binding
TgeneLIMCH1chr3:149589944chr4:41652408ENST0000051282010261011_10775431070.0DomainLIM zinc-binding
TgeneLIMCH1chr3:149589944chr4:41652408ENST0000051294611261011_10775551058.0DomainLIM zinc-binding
TgeneLIMCH1chr3:149589944chr4:41652408ENST0000051302410261011_1077384911.0DomainLIM zinc-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRNF13chr3:149589944chr4:41652408ENST00000344229+51165_160107382.0DomainNote=PA
HgeneRNF13chr3:149589944chr4:41652408ENST00000392894+41065_160107382.0DomainNote=PA
HgeneRNF13chr3:149589944chr4:41652408ENST00000344229+511204_381107382.0Topological domainCytoplasmic
HgeneRNF13chr3:149589944chr4:41652408ENST00000344229+51135_182107382.0Topological domainLumenal
HgeneRNF13chr3:149589944chr4:41652408ENST00000392894+410204_381107382.0Topological domainCytoplasmic
HgeneRNF13chr3:149589944chr4:41652408ENST00000392894+41035_182107382.0Topological domainLumenal
HgeneRNF13chr3:149589944chr4:41652408ENST00000344229+511183_203107382.0TransmembraneHelical
HgeneRNF13chr3:149589944chr4:41652408ENST00000392894+410183_203107382.0TransmembraneHelical
HgeneRNF13chr3:149589944chr4:41652408ENST00000344229+511240_282107382.0Zinc fingerRING-type%3B atypical
HgeneRNF13chr3:149589944chr4:41652408ENST00000392894+410240_282107382.0Zinc fingerRING-type%3B atypical
TgeneLIMCH1chr3:149589944chr4:41652408ENST000003138601127354_4395551084.0Coiled coilOntology_term=ECO:0000255
TgeneLIMCH1chr3:149589944chr4:41652408ENST00000381753520354_439389891.0Coiled coilOntology_term=ECO:0000255
TgeneLIMCH1chr3:149589944chr4:41652408ENST00000396595621354_439401903.0Coiled coilOntology_term=ECO:0000255
TgeneLIMCH1chr3:149589944chr4:41652408ENST000005085011126354_4395551057.0Coiled coilOntology_term=ECO:0000255
TgeneLIMCH1chr3:149589944chr4:41652408ENST00000511496823354_439396898.0Coiled coilOntology_term=ECO:0000255
TgeneLIMCH1chr3:149589944chr4:41652408ENST000005128201026354_4395431070.0Coiled coilOntology_term=ECO:0000255
TgeneLIMCH1chr3:149589944chr4:41652408ENST000005129461126354_4395551058.0Coiled coilOntology_term=ECO:0000255
TgeneLIMCH1chr3:149589944chr4:41652408ENST000005130241026354_439384911.0Coiled coilOntology_term=ECO:0000255
TgeneLIMCH1chr3:149589944chr4:41652408ENST00000313860112721_1255551084.0DomainCalponin-homology (CH)
TgeneLIMCH1chr3:149589944chr4:41652408ENST0000038175352021_125389891.0DomainCalponin-homology (CH)
TgeneLIMCH1chr3:149589944chr4:41652408ENST0000039659562121_125401903.0DomainCalponin-homology (CH)
TgeneLIMCH1chr3:149589944chr4:41652408ENST00000508501112621_1255551057.0DomainCalponin-homology (CH)
TgeneLIMCH1chr3:149589944chr4:41652408ENST0000051149682321_125396898.0DomainCalponin-homology (CH)
TgeneLIMCH1chr3:149589944chr4:41652408ENST00000512820102621_1255431070.0DomainCalponin-homology (CH)
TgeneLIMCH1chr3:149589944chr4:41652408ENST00000512946112621_1255551058.0DomainCalponin-homology (CH)
TgeneLIMCH1chr3:149589944chr4:41652408ENST00000513024102621_125384911.0DomainCalponin-homology (CH)


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Fusion Gene Sequence for RNF13-LIMCH1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>74798_74798_1_RNF13-LIMCH1_RNF13_chr3_149589944_ENST00000344229_LIMCH1_chr4_41652408_ENST00000513024_length(transcript)=4422nt_BP=1023nt
CCCGCCCGGGGGCAGCCCGGCAGCCGAATCTTGGGCTACTCTGTCCCAACAGCCGGAGCAGATCAGACCGACCGGCCCTGCCCGCTCGGT
CCCGCGCCCTCCAGACCCTACGGTCTCCGTTTCTAGGGGCACATGGTTAGCGGCAGGCGCCCACAGCCAATCCACTTTGCCAGCCTGCCC
CTTCCTCTGCCAAGAGCAGCTTCTTCAGCCGCGCTCCAGTTCCGCAGACGCCTGCCCCACCCTGCTCTTCCCTTCCAGGGAAGACGGATC
ACGCGGCCAAGAACGAGACTCGCAAACTGGGCATTTCTCCGAGCCGGGCTAGAGCAAGTAGCGAGACTCCGCGTGAGAGTGGGAAAGAGC
CTTAACAGGCAACCATGTTGCCCAGTGGGTTTTCTGTGCCTTTGGGTGCGGACCAATGAGGCGCGTGGGGCGGGACTTCCGCTTCGCCTA
GGTGTTGTCGTCCCTGCTAGTACTCCGGGCTGTGGGGGTCGGTGCGGATATTCAGTCATGAAATCAGGGTAGGGACTTCTCCCGCAGCGA
CGCGGCTGGCAAGACTGTTTGTGTTGCGGGGGCCGGACTTCAAGAGAGAAAGAGAGAGTGGGCAGACATCGAAGCCAAACAGCAGTATCC
CGGAAGCACTCATGCAACTTTGGTGGCGGCCACTCAGTTTTCTCTGCCAGTGTCTGGTGATTTTACAACGAGATGCTGCTCTCCATAGGG
ATGCTCATGCTGTCAGCCACACAAGTCTACACCATCTTGACTGTCCAGCTCTTTGCATTCTTAAACCTACTGCCTGTAGAAGCAGACATT
TTAGCATATAACTTTGAAAATGCATCTCAGACATTTGATGACCTCCCTGCAAGATTTGGTTATAGACTTCCAGCTGAAGGTTTAAAGGGT
TTTTTGATTAACTCAAAACCAGAGAATGCCTGTGAACCCATAGTGCCTCCACCAGTAAAAGACAATTCATCTGGCACTTTCATCGTGTTA
ATTAGAAGACTTGATTGTAATTTTGATATAAAGGTAGACGGGAAAGTCAGTGTGAATGGAGAGACGGTTCATAGAGAGGAGGAGAAGGAA
AGAGAGTGTCCCACGGTGGCACCTGCCCACTCCTTAACCAAATCCCAGATGTTTGAAGGTGTGGCCAGAGTGCACGGGTCTCCACTGGAG
CTGAAACAAGACAACGGTAGCATCGAGATCAACATAAAGAAGCCAAACTCTGTTCCCCAAGAGCTCGCAGCAACCACTGAGAAAACGGAA
CCGAATAGTCAAGAGGACAAGAATGATGGTGGAAAATCAAGAAAAGGGAATATAGAACTTGCCTCATCAGAACCACAGCATTTTACAACA
ACTGTGACTCGATGCAGCCCGACCGTGGCCTTTGTGGAATTTCCCTCCAGCCCCCAGCTGAAGAATGATGTGTCGGAAGAAAAAGACCAG
AAGAAACCAGAAAATGAAATGAGTGGAAAGGTGGAGTTGGTGCTGTCACAAAAGGTGGTAAAGCCAAAATCTCCAGAACCCGAAGCAACG
CTGACATTTCCATTTCTGGACAAAATGCCTGAAGCCAACCAACTACATTTGCCAAATCTCAATTCTCAAGAGTCGCCTGGCACTGCCAGT
GTTCCGCTTAGAGTTCAGAACTCTTGGCGACGATCCCAGTTTTTCTCCCAGTCAGTGGATTCTCCAAGCAGTGAGAAGTCACCTGTTATG
ACACCTTTTAAGTTCTGGGCATGGGACCCAGAAGAGGAGCGCAGGCGACAGGAAAAATGGCAACAGGAACAGGAACGTTTGCTCCAGGAG
AGATACCAGAAGGAGCAGGACAAGCTGAAAGAAGAGTGGGAAAAGGCCCAAAAGGAGGTGGAAGAGGAAGAACGCAGATACTATGAGGAG
GAGCGTAAGATAATTGAAGACACTGTGGTTCCATTTACTGTTTCTTCAAGTTCCGCTGACCAGCTGTCTACCTCTTCCTCCATGACTGAA
GGCAGTGGGACAATGAATAAGATAGACCTGGGAAACTGTCAAGATGAAAAACAAGACAGAAGATGGAAGAAATCATTCCAGGGAGATGAC
AGTGACTTATTGCTGAAGACTAGGGAAAGTGATCGACTGGAGGAGAAGGGCAGCCTAACTGAAGGGGCCTTGGCTCATTCTGGGAACCCT
GTATCAAAAGGAGTCCATGAAGACCATCAGCTGGATACCGAGGCTGGGGCCCCACACTGTGGAACAAACCCACAGCTTGCTCAGGATCCA
TCCCAGAATCAGCAGACATCAAATCCAACGCACAGTTCAGAAGATGTGAAGCCAAAAACCCTCCCGCTGGATAAAAGCATTAACCATCAG
ATCGAGTCTCCCAGTGAAAGGCGGAAGTCTATAAGTGGAAAGAAGCTGTGCTCTTCCTGTGGGCTTCCTTTGGGTAAAGGAGCTGCAATG
ATCATCGAGACCCTCAATCTCTATTTTCACATCCAGTGTTTCAGGTGTGGAATTTGTAAAGGCCAGCTTGGAGATGCAGTGAGTGGGACG
GATGTTAGGATTCGAAATGGTCTCCTGAACTGTAATGATTGCTACATGCGATCCAGAAGTGCCGGGCAGCCTACAACATTGTGACACGGC
TTTCAAGCTTCCGGATCACTCACCATTTCTTTACTGAGAGTGTCCCCTGGCAACTGCTTAACAAAATCCCAAGCTCAGGGGCTTCTCAGC
ATTTACCTAATTTCTGAAAGGCTCTTCTGAAAGGTGGTATCTGTTCTTTCGTAGCACAGTGTTTATGTTTTTCCTGTTTATTGTTTTGGT
TTTTTTTTTTTTTTTGCATTTGCACAGTATACACAAAAGAATATGGGGTTGTAATGATCCTGAATAGCTCAAAAAAGGTTTTAGCATGGT
CAAACAGGCTTATGGTTTAAAATGTGTTATTCTCTTCTTTGGGAATTAGCTAAATGATGCAATAAACCTGTTTTGTTTTAGAATGTCTAG
GAATTAAACACTTTATGTTTACAGAATTGAGCTGCAGAAAGTGCAAGACATGCCAATTTGAGACACACGGTCTTCTAAGACTGAAGGATA
AATTTAATGCATTTCAGAAACTAAACATCACAGCAAGCTCTATCTCTGAGCTATAATTTGTTTTTAATGCAAAGACACTAGTTTGATAAT
ATATACTGTAATCCTGAAACATTTGTGTTACTTACCTTTGGAGGTAGAAATTATACCAATAAATTATTGCACCGTTAGTATTAGATTCTG
TGTACCTTGGAAGTTATGTCATTAATATAGGCTGGTTCATCAAATAAAGCAAAACCTTGCAATATCAGCTAGATTTACACTCCGGGACGT
TGCCCAAAGGTAGGAAGAAAGCAGAGGGAAATATTTCAGTCATCATTTCCAAAGTCATTATCAAAATCTGTGAGGAAGTTTAATCTTCCA
AAGAGTCAATGTCAGACATCAGGCCTCTGTTGCCTGCTTCTCTCGAGGCACTAGATTAGGAGTCTTCAATAAGAGACTTAACATGAGGTA
TATGGAAGATGAGGCACCGAGATAAGTTCATCATTAGGTGTGAGCACTGCTCACCCTTGCTGGCAAGTTCTCCTTAAGGGCCTGAAGCAC
AGGTGTCCAAAGAAAAGCGTTAAGTCCATCTTAATAGAATCTATGTGGTATATGATGTGGTCAGCCCCTGGTCTGTGATCAGCAAGAACC
TACAGCACAGATTATGCCCTGCCCACTTCAATGAATACCTACTCTCCTCCATTCTCCATCACTTTTTTTGCTATCAAGAACTCCGGACCT
TGCCCATGGAGAAGTTTAGAGAGGAACTCTTGTGGAGAGCTGGTTTATTTTCTGCCCTGTGCGACGAGTTTCAGCTGGCCAAGAAAGGAG
TCAAGTTATTAAAAAGCATCACAATGTAGATCTCCAGGCTGGTTTTTTGTTTTTTGTTGTTAAGACTGGGGAAAGGGGGACTATTTATTC
TGCCTTAAATCAATGGCAAATAAGTCAAGATGACATTTTGTGAATGTAGACTATGGATACACTCCTAATAGATTGATGTAGTCATAAAAG
GGGGTCAAGTAGATGTTTTTCTGTTATGTAAGCAATAATTTTTCCGTGTCTTATTGAGTATGGCTAGCGATTATTTATTACATGCTAGAT
GGGTTCTTTGCATGTGGGTTCCATATAGGTGCAGAAATTTCCTCAGCCACTGGAGGGATTTCGACCATATTTGTCATTTGGATGAGCTGT
TATTAGATTGAAATCTACACATCATTTCATTAAAAATTGTGCCTTAGAAAACGCAAAGCTGTTGCACATGGCGATAAATTATGGATGCAG
TACATTGAAGAGAGATGAAGTCACTTCCAAGTTTCCAAGACTTCTCATGGAGGTGTTTGCTGTTTTACAGGAAAAAATAAAAATAAAAAA

>74798_74798_1_RNF13-LIMCH1_RNF13_chr3_149589944_ENST00000344229_LIMCH1_chr4_41652408_ENST00000513024_length(amino acids)=633AA_BP=107
MLLSIGMLMLSATQVYTILTVQLFAFLNLLPVEADILAYNFENASQTFDDLPARFGYRLPAEGLKGFLINSKPENACEPIVPPPVKDNSS
GTFIVLIRRLDCNFDIKVDGKVSVNGETVHREEEKERECPTVAPAHSLTKSQMFEGVARVHGSPLELKQDNGSIEINIKKPNSVPQELAA
TTEKTEPNSQEDKNDGGKSRKGNIELASSEPQHFTTTVTRCSPTVAFVEFPSSPQLKNDVSEEKDQKKPENEMSGKVELVLSQKVVKPKS
PEPEATLTFPFLDKMPEANQLHLPNLNSQESPGTASVPLRVQNSWRRSQFFSQSVDSPSSEKSPVMTPFKFWAWDPEEERRRQEKWQQEQ
ERLLQERYQKEQDKLKEEWEKAQKEVEEEERRYYEEERKIIEDTVVPFTVSSSSADQLSTSSSMTEGSGTMNKIDLGNCQDEKQDRRWKK
SFQGDDSDLLLKTRESDRLEEKGSLTEGALAHSGNPVSKGVHEDHQLDTEAGAPHCGTNPQLAQDPSQNQQTSNPTHSSEDVKPKTLPLD
KSINHQIESPSERRKSISGKKLCSSCGLPLGKGAAMIIETLNLYFHIQCFRCGICKGQLGDAVSGTDVRIRNGLLNCNDCYMRSRSAGQP

--------------------------------------------------------------
>74798_74798_2_RNF13-LIMCH1_RNF13_chr3_149589944_ENST00000392894_LIMCH1_chr4_41652408_ENST00000513024_length(transcript)=4382nt_BP=983nt
CTCTTTAGTAGGTCGGGTGAGTGTAGTGTGCAGGGAAGAGACGCGTCAGCGCCAGGGCCAGGCCCGCCCGGGGGCAGCCCGGCAGCCGAA
TCTTGGGCTACTCTGTCCCAACAGCCGGAGCAGATCAGACCGACCGGCCCTGCCCGCTCGGTCCCGCGCCCTCCAGACCCTACGGTCTCC
GTTTCTAGGGGCACATGGTTAGCGGCAGGCGCCCACAGCCAATCCACTTTGCCAGCCTGCCCCTTCCTCTGCCAAGAGCAGCTTCTTCAG
CCGCGCTCCAGTTCCGCAGACGCCTGCCCCACCCTGCTCTTCCCTTCCAGGGAAGACGGATCACGCGGCCAAGAACGAGACTCGCAAACT
GGGCATTTCTCCGAGCCGGGCTAGAGCAAGTAGCGAGACTCCGCGTGAGAGTGGGAAAGAGCCTTAACAGGCAACCATGTTGCCCAGTGG
GTTTTCTGTGCCTTTGGGTGCGGACCAATGAGGCGCGTGGGGCGGGACTTCCGCTTCGCCTAGGTGTTGTCGTCCCTGCTAGTACTCCGG
GCTGTGGGGGTCGGTGCGGATATTCAGTCATGAAATCAGGGTAGGGACTTCTCCCGCAGCGACGCGGCTGGCAAGACTGTTTGTGTTGCG
GGGGCCGGACTTCAAGGTGATTTTACAACGAGATGCTGCTCTCCATAGGGATGCTCATGCTGTCAGCCACACAAGTCTACACCATCTTGA
CTGTCCAGCTCTTTGCATTCTTAAACCTACTGCCTGTAGAAGCAGACATTTTAGCATATAACTTTGAAAATGCATCTCAGACATTTGATG
ACCTCCCTGCAAGATTTGGTTATAGACTTCCAGCTGAAGGTTTAAAGGGTTTTTTGATTAACTCAAAACCAGAGAATGCCTGTGAACCCA
TAGTGCCTCCACCAGTAAAAGACAATTCATCTGGCACTTTCATCGTGTTAATTAGAAGACTTGATTGTAATTTTGATATAAAGGTAGACG
GGAAAGTCAGTGTGAATGGAGAGACGGTTCATAGAGAGGAGGAGAAGGAAAGAGAGTGTCCCACGGTGGCACCTGCCCACTCCTTAACCA
AATCCCAGATGTTTGAAGGTGTGGCCAGAGTGCACGGGTCTCCACTGGAGCTGAAACAAGACAACGGTAGCATCGAGATCAACATAAAGA
AGCCAAACTCTGTTCCCCAAGAGCTCGCAGCAACCACTGAGAAAACGGAACCGAATAGTCAAGAGGACAAGAATGATGGTGGAAAATCAA
GAAAAGGGAATATAGAACTTGCCTCATCAGAACCACAGCATTTTACAACAACTGTGACTCGATGCAGCCCGACCGTGGCCTTTGTGGAAT
TTCCCTCCAGCCCCCAGCTGAAGAATGATGTGTCGGAAGAAAAAGACCAGAAGAAACCAGAAAATGAAATGAGTGGAAAGGTGGAGTTGG
TGCTGTCACAAAAGGTGGTAAAGCCAAAATCTCCAGAACCCGAAGCAACGCTGACATTTCCATTTCTGGACAAAATGCCTGAAGCCAACC
AACTACATTTGCCAAATCTCAATTCTCAAGAGTCGCCTGGCACTGCCAGTGTTCCGCTTAGAGTTCAGAACTCTTGGCGACGATCCCAGT
TTTTCTCCCAGTCAGTGGATTCTCCAAGCAGTGAGAAGTCACCTGTTATGACACCTTTTAAGTTCTGGGCATGGGACCCAGAAGAGGAGC
GCAGGCGACAGGAAAAATGGCAACAGGAACAGGAACGTTTGCTCCAGGAGAGATACCAGAAGGAGCAGGACAAGCTGAAAGAAGAGTGGG
AAAAGGCCCAAAAGGAGGTGGAAGAGGAAGAACGCAGATACTATGAGGAGGAGCGTAAGATAATTGAAGACACTGTGGTTCCATTTACTG
TTTCTTCAAGTTCCGCTGACCAGCTGTCTACCTCTTCCTCCATGACTGAAGGCAGTGGGACAATGAATAAGATAGACCTGGGAAACTGTC
AAGATGAAAAACAAGACAGAAGATGGAAGAAATCATTCCAGGGAGATGACAGTGACTTATTGCTGAAGACTAGGGAAAGTGATCGACTGG
AGGAGAAGGGCAGCCTAACTGAAGGGGCCTTGGCTCATTCTGGGAACCCTGTATCAAAAGGAGTCCATGAAGACCATCAGCTGGATACCG
AGGCTGGGGCCCCACACTGTGGAACAAACCCACAGCTTGCTCAGGATCCATCCCAGAATCAGCAGACATCAAATCCAACGCACAGTTCAG
AAGATGTGAAGCCAAAAACCCTCCCGCTGGATAAAAGCATTAACCATCAGATCGAGTCTCCCAGTGAAAGGCGGAAGTCTATAAGTGGAA
AGAAGCTGTGCTCTTCCTGTGGGCTTCCTTTGGGTAAAGGAGCTGCAATGATCATCGAGACCCTCAATCTCTATTTTCACATCCAGTGTT
TCAGGTGTGGAATTTGTAAAGGCCAGCTTGGAGATGCAGTGAGTGGGACGGATGTTAGGATTCGAAATGGTCTCCTGAACTGTAATGATT
GCTACATGCGATCCAGAAGTGCCGGGCAGCCTACAACATTGTGACACGGCTTTCAAGCTTCCGGATCACTCACCATTTCTTTACTGAGAG
TGTCCCCTGGCAACTGCTTAACAAAATCCCAAGCTCAGGGGCTTCTCAGCATTTACCTAATTTCTGAAAGGCTCTTCTGAAAGGTGGTAT
CTGTTCTTTCGTAGCACAGTGTTTATGTTTTTCCTGTTTATTGTTTTGGTTTTTTTTTTTTTTTTGCATTTGCACAGTATACACAAAAGA
ATATGGGGTTGTAATGATCCTGAATAGCTCAAAAAAGGTTTTAGCATGGTCAAACAGGCTTATGGTTTAAAATGTGTTATTCTCTTCTTT
GGGAATTAGCTAAATGATGCAATAAACCTGTTTTGTTTTAGAATGTCTAGGAATTAAACACTTTATGTTTACAGAATTGAGCTGCAGAAA
GTGCAAGACATGCCAATTTGAGACACACGGTCTTCTAAGACTGAAGGATAAATTTAATGCATTTCAGAAACTAAACATCACAGCAAGCTC
TATCTCTGAGCTATAATTTGTTTTTAATGCAAAGACACTAGTTTGATAATATATACTGTAATCCTGAAACATTTGTGTTACTTACCTTTG
GAGGTAGAAATTATACCAATAAATTATTGCACCGTTAGTATTAGATTCTGTGTACCTTGGAAGTTATGTCATTAATATAGGCTGGTTCAT
CAAATAAAGCAAAACCTTGCAATATCAGCTAGATTTACACTCCGGGACGTTGCCCAAAGGTAGGAAGAAAGCAGAGGGAAATATTTCAGT
CATCATTTCCAAAGTCATTATCAAAATCTGTGAGGAAGTTTAATCTTCCAAAGAGTCAATGTCAGACATCAGGCCTCTGTTGCCTGCTTC
TCTCGAGGCACTAGATTAGGAGTCTTCAATAAGAGACTTAACATGAGGTATATGGAAGATGAGGCACCGAGATAAGTTCATCATTAGGTG
TGAGCACTGCTCACCCTTGCTGGCAAGTTCTCCTTAAGGGCCTGAAGCACAGGTGTCCAAAGAAAAGCGTTAAGTCCATCTTAATAGAAT
CTATGTGGTATATGATGTGGTCAGCCCCTGGTCTGTGATCAGCAAGAACCTACAGCACAGATTATGCCCTGCCCACTTCAATGAATACCT
ACTCTCCTCCATTCTCCATCACTTTTTTTGCTATCAAGAACTCCGGACCTTGCCCATGGAGAAGTTTAGAGAGGAACTCTTGTGGAGAGC
TGGTTTATTTTCTGCCCTGTGCGACGAGTTTCAGCTGGCCAAGAAAGGAGTCAAGTTATTAAAAAGCATCACAATGTAGATCTCCAGGCT
GGTTTTTTGTTTTTTGTTGTTAAGACTGGGGAAAGGGGGACTATTTATTCTGCCTTAAATCAATGGCAAATAAGTCAAGATGACATTTTG
TGAATGTAGACTATGGATACACTCCTAATAGATTGATGTAGTCATAAAAGGGGGTCAAGTAGATGTTTTTCTGTTATGTAAGCAATAATT
TTTCCGTGTCTTATTGAGTATGGCTAGCGATTATTTATTACATGCTAGATGGGTTCTTTGCATGTGGGTTCCATATAGGTGCAGAAATTT
CCTCAGCCACTGGAGGGATTTCGACCATATTTGTCATTTGGATGAGCTGTTATTAGATTGAAATCTACACATCATTTCATTAAAAATTGT
GCCTTAGAAAACGCAAAGCTGTTGCACATGGCGATAAATTATGGATGCAGTACATTGAAGAGAGATGAAGTCACTTCCAAGTTTCCAAGA

>74798_74798_2_RNF13-LIMCH1_RNF13_chr3_149589944_ENST00000392894_LIMCH1_chr4_41652408_ENST00000513024_length(amino acids)=633AA_BP=107
MLLSIGMLMLSATQVYTILTVQLFAFLNLLPVEADILAYNFENASQTFDDLPARFGYRLPAEGLKGFLINSKPENACEPIVPPPVKDNSS
GTFIVLIRRLDCNFDIKVDGKVSVNGETVHREEEKERECPTVAPAHSLTKSQMFEGVARVHGSPLELKQDNGSIEINIKKPNSVPQELAA
TTEKTEPNSQEDKNDGGKSRKGNIELASSEPQHFTTTVTRCSPTVAFVEFPSSPQLKNDVSEEKDQKKPENEMSGKVELVLSQKVVKPKS
PEPEATLTFPFLDKMPEANQLHLPNLNSQESPGTASVPLRVQNSWRRSQFFSQSVDSPSSEKSPVMTPFKFWAWDPEEERRRQEKWQQEQ
ERLLQERYQKEQDKLKEEWEKAQKEVEEEERRYYEEERKIIEDTVVPFTVSSSSADQLSTSSSMTEGSGTMNKIDLGNCQDEKQDRRWKK
SFQGDDSDLLLKTRESDRLEEKGSLTEGALAHSGNPVSKGVHEDHQLDTEAGAPHCGTNPQLAQDPSQNQQTSNPTHSSEDVKPKTLPLD
KSINHQIESPSERRKSISGKKLCSSCGLPLGKGAAMIIETLNLYFHIQCFRCGICKGQLGDAVSGTDVRIRNGLLNCNDCYMRSRSAGQP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RNF13-LIMCH1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RNF13-LIMCH1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RNF13-LIMCH1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource