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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RNF13-TM4SF4 (FusionGDB2 ID:74802)

Fusion Gene Summary for RNF13-TM4SF4

check button Fusion gene summary
Fusion gene informationFusion gene name: RNF13-TM4SF4
Fusion gene ID: 74802
HgeneTgene
Gene symbol

RNF13

TM4SF4

Gene ID

11342

7104

Gene namering finger protein 13transmembrane 4 L six family member 4
SynonymsEIEE73|RZFILTMP|il-TMP
Cytomap

3q25.1

3q25.1

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase RNF13RING zinc finger proteinRING-type E3 ubiquitin transferase RNF13transmembrane 4 L6 family member 4intestinal and liver (il) tetraspan membrane proteinintestine and liver tetraspan membrane proteintransmembrane 4 superfamily member 4
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000344229, ENST00000361785, 
ENST00000392894, 		ENST00000305354, 
Fusion gene scores* DoF score10 X 9 X 7=6305 X 6 X 6=180
# samples 138
** MAII scorelog2(13/630*10)=-2.27684020535882
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/180*10)=-1.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RNF13 [Title/Abstract] AND TM4SF4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRNF13(149531140)-TM4SF4(149216509), # samples:3
RNF13(149589941)-TM4SF4(149205406), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across RNF13 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TM4SF4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A7-A26G-01ARNF13chr3

149531140

-TM4SF4chr3

149216509

+
ChimerDB4BRCATCGA-A7-A26G-01ARNF13chr3

149531140

+TM4SF4chr3

149216509

+
ChimerDB4GBMTCGA-4W-AA9R-01ARNF13chr3

149570383

+TM4SF4chr3

149193610

+
ChimerDB4OVTCGA-13-1495-01ARNF13chr3

149531140

+TM4SF4chr3

149192762

+
ChimerDB4OVTCGA-13-1495-01ARNF13chr3

149531140

-TM4SF4chr3

149193610

+
ChimerDB4OVTCGA-13-1495-01ARNF13chr3

149531140

+TM4SF4chr3

149205406

+
ChimerDB4UCSTCGA-N5-A4RA-01ARNF13chr3

149589941

-TM4SF4chr3

149205406

+
ChimerDB4UCSTCGA-N5-A4RA-01ARNF13chr3

149589941

+TM4SF4chr3

149205406

+
ChimerDB4UCSTCGA-N5-A4RARNF13chr3

149589941

+TM4SF4chr3

149205406

+


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Fusion Gene ORF analysis for RNF13-TM4SF4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000344229ENST00000305354RNF13chr3

149531140

+TM4SF4chr3

149216509

+
5UTR-3CDSENST00000344229ENST00000305354RNF13chr3

149531140

+TM4SF4chr3

149192762

+
5UTR-3CDSENST00000344229ENST00000305354RNF13chr3

149531140

-TM4SF4chr3

149193610

+
5UTR-3CDSENST00000344229ENST00000305354RNF13chr3

149531140

+TM4SF4chr3

149205406

+
5UTR-3CDSENST00000361785ENST00000305354RNF13chr3

149589941

+TM4SF4chr3

149205406

+
5UTR-3CDSENST00000392894ENST00000305354RNF13chr3

149531140

+TM4SF4chr3

149216509

+
5UTR-3CDSENST00000392894ENST00000305354RNF13chr3

149531140

+TM4SF4chr3

149192762

+
5UTR-3CDSENST00000392894ENST00000305354RNF13chr3

149531140

-TM4SF4chr3

149193610

+
5UTR-3CDSENST00000392894ENST00000305354RNF13chr3

149531140

+TM4SF4chr3

149205406

+
In-frameENST00000344229ENST00000305354RNF13chr3

149570383

+TM4SF4chr3

149193610

+
In-frameENST00000344229ENST00000305354RNF13chr3

149589941

+TM4SF4chr3

149205406

+
In-frameENST00000392894ENST00000305354RNF13chr3

149570383

+TM4SF4chr3

149193610

+
In-frameENST00000392894ENST00000305354RNF13chr3

149589941

+TM4SF4chr3

149205406

+
intron-3CDSENST00000361785ENST00000305354RNF13chr3

149531140

+TM4SF4chr3

149216509

+
intron-3CDSENST00000361785ENST00000305354RNF13chr3

149570383

+TM4SF4chr3

149193610

+
intron-3CDSENST00000361785ENST00000305354RNF13chr3

149531140

+TM4SF4chr3

149192762

+
intron-3CDSENST00000361785ENST00000305354RNF13chr3

149531140

-TM4SF4chr3

149193610

+
intron-3CDSENST00000361785ENST00000305354RNF13chr3

149531140

+TM4SF4chr3

149205406

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000392894RNF13chr3149570383+ENST00000305354TM4SF4chr3149193610+18808576621291209
ENST00000344229RNF13chr3149570383+ENST00000305354TM4SF4chr3149193610+19208977021331209
ENST00000392894RNF13chr3149589941+ENST00000305354TM4SF4chr3149205406+19169836621327221
ENST00000344229RNF13chr3149589941+ENST00000305354TM4SF4chr3149205406+195610237021367221

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000392894ENST00000305354RNF13chr3149570383+TM4SF4chr3149193610+0.0015970590.9984029
ENST00000344229ENST00000305354RNF13chr3149570383+TM4SF4chr3149193610+0.0020369210.9979631
ENST00000392894ENST00000305354RNF13chr3149589941+TM4SF4chr3149205406+0.0010270120.998973
ENST00000344229ENST00000305354RNF13chr3149589941+TM4SF4chr3149205406+0.0016445650.99835545

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Fusion Genomic Features for RNF13-TM4SF4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RNF13chr3149531140+TM4SF4chr3149216508+1.52E-050.99998486
RNF13chr3149589941+TM4SF4chr3149205405+1.17E-050.9999883
RNF13chr3149589941+TM4SF4chr3149205405+1.17E-050.9999883
RNF13chr3149570383+TM4SF4chr3149193609+9.42E-070.99999905
RNF13chr3149531140+TM4SF4chr3149205405+3.42E-081
RNF13chr3149531140+TM4SF4chr3149216508+1.52E-050.99998486
RNF13chr3149589941+TM4SF4chr3149205405+1.17E-050.9999883
RNF13chr3149589941+TM4SF4chr3149205405+1.17E-050.9999883
RNF13chr3149570383+TM4SF4chr3149193609+9.42E-070.99999905
RNF13chr3149531140+TM4SF4chr3149205405+3.42E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for RNF13-TM4SF4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:149531140/chr3:149216509)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTM4SF4chr3:149570383chr3:149193610ENST0000030535405115_15858203.0Topological domainExtracellular
TgeneTM4SF4chr3:149570383chr3:149193610ENST0000030535405180_20258203.0Topological domainCytoplasmic
TgeneTM4SF4chr3:149570383chr3:149193610ENST000003053540567_9358203.0Topological domainCytoplasmic
TgeneTM4SF4chr3:149589941chr3:149205406ENST0000030535415115_15888203.0Topological domainExtracellular
TgeneTM4SF4chr3:149589941chr3:149205406ENST0000030535415180_20288203.0Topological domainCytoplasmic
TgeneTM4SF4chr3:149570383chr3:149193610ENST0000030535405159_17958203.0TransmembraneHelical
TgeneTM4SF4chr3:149570383chr3:149193610ENST000003053540594_11458203.0TransmembraneHelical
TgeneTM4SF4chr3:149589941chr3:149205406ENST0000030535415159_17988203.0TransmembraneHelical
TgeneTM4SF4chr3:149589941chr3:149205406ENST000003053541594_11488203.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRNF13chr3:149570383chr3:149193610ENST00000344229+41165_16065382.0DomainNote=PA
HgeneRNF13chr3:149570383chr3:149193610ENST00000392894+31065_16065382.0DomainNote=PA
HgeneRNF13chr3:149589941chr3:149205406ENST00000344229+51165_160107382.0DomainNote=PA
HgeneRNF13chr3:149589941chr3:149205406ENST00000392894+41065_160107382.0DomainNote=PA
HgeneRNF13chr3:149570383chr3:149193610ENST00000344229+411204_38165382.0Topological domainCytoplasmic
HgeneRNF13chr3:149570383chr3:149193610ENST00000344229+41135_18265382.0Topological domainLumenal
HgeneRNF13chr3:149570383chr3:149193610ENST00000392894+310204_38165382.0Topological domainCytoplasmic
HgeneRNF13chr3:149570383chr3:149193610ENST00000392894+31035_18265382.0Topological domainLumenal
HgeneRNF13chr3:149589941chr3:149205406ENST00000344229+511204_381107382.0Topological domainCytoplasmic
HgeneRNF13chr3:149589941chr3:149205406ENST00000344229+51135_182107382.0Topological domainLumenal
HgeneRNF13chr3:149589941chr3:149205406ENST00000392894+410204_381107382.0Topological domainCytoplasmic
HgeneRNF13chr3:149589941chr3:149205406ENST00000392894+41035_182107382.0Topological domainLumenal
HgeneRNF13chr3:149570383chr3:149193610ENST00000344229+411183_20365382.0TransmembraneHelical
HgeneRNF13chr3:149570383chr3:149193610ENST00000392894+310183_20365382.0TransmembraneHelical
HgeneRNF13chr3:149589941chr3:149205406ENST00000344229+511183_203107382.0TransmembraneHelical
HgeneRNF13chr3:149589941chr3:149205406ENST00000392894+410183_203107382.0TransmembraneHelical
HgeneRNF13chr3:149570383chr3:149193610ENST00000344229+411240_28265382.0Zinc fingerRING-type%3B atypical
HgeneRNF13chr3:149570383chr3:149193610ENST00000392894+310240_28265382.0Zinc fingerRING-type%3B atypical
HgeneRNF13chr3:149589941chr3:149205406ENST00000344229+511240_282107382.0Zinc fingerRING-type%3B atypical
HgeneRNF13chr3:149589941chr3:149205406ENST00000392894+410240_282107382.0Zinc fingerRING-type%3B atypical
TgeneTM4SF4chr3:149570383chr3:149193610ENST00000305354051_958203.0Topological domainCytoplasmic
TgeneTM4SF4chr3:149570383chr3:149193610ENST000003053540531_4558203.0Topological domainExtracellular
TgeneTM4SF4chr3:149589941chr3:149205406ENST00000305354151_988203.0Topological domainCytoplasmic
TgeneTM4SF4chr3:149589941chr3:149205406ENST000003053541531_4588203.0Topological domainExtracellular
TgeneTM4SF4chr3:149589941chr3:149205406ENST000003053541567_9388203.0Topological domainCytoplasmic
TgeneTM4SF4chr3:149570383chr3:149193610ENST000003053540510_3058203.0TransmembraneHelical
TgeneTM4SF4chr3:149570383chr3:149193610ENST000003053540546_6658203.0TransmembraneHelical
TgeneTM4SF4chr3:149589941chr3:149205406ENST000003053541510_3088203.0TransmembraneHelical
TgeneTM4SF4chr3:149589941chr3:149205406ENST000003053541546_6688203.0TransmembraneHelical


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Fusion Gene Sequence for RNF13-TM4SF4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>74802_74802_1_RNF13-TM4SF4_RNF13_chr3_149570383_ENST00000344229_TM4SF4_chr3_149193610_ENST00000305354_length(transcript)=1920nt_BP=897nt
CCCGCCCGGGGGCAGCCCGGCAGCCGAATCTTGGGCTACTCTGTCCCAACAGCCGGAGCAGATCAGACCGACCGGCCCTGCCCGCTCGGT
CCCGCGCCCTCCAGACCCTACGGTCTCCGTTTCTAGGGGCACATGGTTAGCGGCAGGCGCCCACAGCCAATCCACTTTGCCAGCCTGCCC
CTTCCTCTGCCAAGAGCAGCTTCTTCAGCCGCGCTCCAGTTCCGCAGACGCCTGCCCCACCCTGCTCTTCCCTTCCAGGGAAGACGGATC
ACGCGGCCAAGAACGAGACTCGCAAACTGGGCATTTCTCCGAGCCGGGCTAGAGCAAGTAGCGAGACTCCGCGTGAGAGTGGGAAAGAGC
CTTAACAGGCAACCATGTTGCCCAGTGGGTTTTCTGTGCCTTTGGGTGCGGACCAATGAGGCGCGTGGGGCGGGACTTCCGCTTCGCCTA
GGTGTTGTCGTCCCTGCTAGTACTCCGGGCTGTGGGGGTCGGTGCGGATATTCAGTCATGAAATCAGGGTAGGGACTTCTCCCGCAGCGA
CGCGGCTGGCAAGACTGTTTGTGTTGCGGGGGCCGGACTTCAAGAGAGAAAGAGAGAGTGGGCAGACATCGAAGCCAAACAGCAGTATCC
CGGAAGCACTCATGCAACTTTGGTGGCGGCCACTCAGTTTTCTCTGCCAGTGTCTGGTGATTTTACAACGAGATGCTGCTCTCCATAGGG
ATGCTCATGCTGTCAGCCACACAAGTCTACACCATCTTGACTGTCCAGCTCTTTGCATTCTTAAACCTACTGCCTGTAGAAGCAGACATT
TTAGCATATAACTTTGAAAATGCATCTCAGACATTTGATGACCTCCCTGCAAGATTTGGTTATAGACTTCCAGCTGAAGGTTTAAAGATG
ATCTTCCCTGCGCTGGTGTTCTTGGGCCTGAAGAACAATGACTGCTGTGGGTGCTGCGGCAACGAGGGCTGTGGGAAGCGATTTGCGATG
TTCACCTCCACGATATTTGCTGTGGTTGGATTCTTGGGAGCTGGATACTCGTTTATCATCTCAGCCATTTCAATCAACAAGGGTCCTAAA
TGCCTCATGGCCAATAGTACATGGGGCTACCCCTTCCACGACGGGGATTATCTCAATGATGAGGCCTTATGGAACAAGTGCCGAGAGCCT
CTCAATGTGGTTCCCTGGAATCTGACCCTCTTCTCCATCCTGCTGGTCGTAGGAGGAATCCAGATGGTTCTCTGCGCCATCCAGGTGGTC
AATGGCCTCCTGGGGACCCTCTGTGGGGACTGCCAGTGTTGTGGCTGCTGTGGGGGAGATGGACCCGTTTAAACCTCCGAGATGAGCTGC
TCAGACTCTACAGCATGACGACTACAATTTCTTTTCATAAAACTTCTTCTCTTCTTGGAATTATTAATTCCTATCTGCTTCCTAGCTGAT
AAAGCTTAGAAAAGGCAGTTATTCCTTCTTTCCAACCAGCTTTGCTCGAGTTAGAATTTTGTTATTTTCAAATAAAAAATAGTTTGGCCA
CTTAACAAATTTGATTTATAAATCTTTCAAATTAGTTCCTTTTTAGAATTTACCAACAGGTTCAAAGCATACTTTTCATGATTTTTTTAT
TACAAATGTAAAATGTATAAAGTCACATGTACTGCCATACTACTTCTTTGTATATAAAGATGTTTATATCTTTGGAAGTTTTACATAAAT
CAAAGGAAGAAAGCACATTTAAAATGAGAAACTAAGACCAATTTCTGTTTTTAAGAGGAAAAAGAATGATTGATGTATCCTAAGTATTGT
TATTTGTTGTCTTTTTTTGCTGCCTTGCTTGAGTTGCTTGTGACTGATCTTTTGAGGCTGTCATCATGGCTAGGGTTCTTTTATGTATGT

>74802_74802_1_RNF13-TM4SF4_RNF13_chr3_149570383_ENST00000344229_TM4SF4_chr3_149193610_ENST00000305354_length(amino acids)=209AA_BP=65
MLLSIGMLMLSATQVYTILTVQLFAFLNLLPVEADILAYNFENASQTFDDLPARFGYRLPAEGLKMIFPALVFLGLKNNDCCGCCGNEGC
GKRFAMFTSTIFAVVGFLGAGYSFIISAISINKGPKCLMANSTWGYPFHDGDYLNDEALWNKCREPLNVVPWNLTLFSILLVVGGIQMVL

--------------------------------------------------------------
>74802_74802_2_RNF13-TM4SF4_RNF13_chr3_149570383_ENST00000392894_TM4SF4_chr3_149193610_ENST00000305354_length(transcript)=1880nt_BP=857nt
CTCTTTAGTAGGTCGGGTGAGTGTAGTGTGCAGGGAAGAGACGCGTCAGCGCCAGGGCCAGGCCCGCCCGGGGGCAGCCCGGCAGCCGAA
TCTTGGGCTACTCTGTCCCAACAGCCGGAGCAGATCAGACCGACCGGCCCTGCCCGCTCGGTCCCGCGCCCTCCAGACCCTACGGTCTCC
GTTTCTAGGGGCACATGGTTAGCGGCAGGCGCCCACAGCCAATCCACTTTGCCAGCCTGCCCCTTCCTCTGCCAAGAGCAGCTTCTTCAG
CCGCGCTCCAGTTCCGCAGACGCCTGCCCCACCCTGCTCTTCCCTTCCAGGGAAGACGGATCACGCGGCCAAGAACGAGACTCGCAAACT
GGGCATTTCTCCGAGCCGGGCTAGAGCAAGTAGCGAGACTCCGCGTGAGAGTGGGAAAGAGCCTTAACAGGCAACCATGTTGCCCAGTGG
GTTTTCTGTGCCTTTGGGTGCGGACCAATGAGGCGCGTGGGGCGGGACTTCCGCTTCGCCTAGGTGTTGTCGTCCCTGCTAGTACTCCGG
GCTGTGGGGGTCGGTGCGGATATTCAGTCATGAAATCAGGGTAGGGACTTCTCCCGCAGCGACGCGGCTGGCAAGACTGTTTGTGTTGCG
GGGGCCGGACTTCAAGGTGATTTTACAACGAGATGCTGCTCTCCATAGGGATGCTCATGCTGTCAGCCACACAAGTCTACACCATCTTGA
CTGTCCAGCTCTTTGCATTCTTAAACCTACTGCCTGTAGAAGCAGACATTTTAGCATATAACTTTGAAAATGCATCTCAGACATTTGATG
ACCTCCCTGCAAGATTTGGTTATAGACTTCCAGCTGAAGGTTTAAAGATGATCTTCCCTGCGCTGGTGTTCTTGGGCCTGAAGAACAATG
ACTGCTGTGGGTGCTGCGGCAACGAGGGCTGTGGGAAGCGATTTGCGATGTTCACCTCCACGATATTTGCTGTGGTTGGATTCTTGGGAG
CTGGATACTCGTTTATCATCTCAGCCATTTCAATCAACAAGGGTCCTAAATGCCTCATGGCCAATAGTACATGGGGCTACCCCTTCCACG
ACGGGGATTATCTCAATGATGAGGCCTTATGGAACAAGTGCCGAGAGCCTCTCAATGTGGTTCCCTGGAATCTGACCCTCTTCTCCATCC
TGCTGGTCGTAGGAGGAATCCAGATGGTTCTCTGCGCCATCCAGGTGGTCAATGGCCTCCTGGGGACCCTCTGTGGGGACTGCCAGTGTT
GTGGCTGCTGTGGGGGAGATGGACCCGTTTAAACCTCCGAGATGAGCTGCTCAGACTCTACAGCATGACGACTACAATTTCTTTTCATAA
AACTTCTTCTCTTCTTGGAATTATTAATTCCTATCTGCTTCCTAGCTGATAAAGCTTAGAAAAGGCAGTTATTCCTTCTTTCCAACCAGC
TTTGCTCGAGTTAGAATTTTGTTATTTTCAAATAAAAAATAGTTTGGCCACTTAACAAATTTGATTTATAAATCTTTCAAATTAGTTCCT
TTTTAGAATTTACCAACAGGTTCAAAGCATACTTTTCATGATTTTTTTATTACAAATGTAAAATGTATAAAGTCACATGTACTGCCATAC
TACTTCTTTGTATATAAAGATGTTTATATCTTTGGAAGTTTTACATAAATCAAAGGAAGAAAGCACATTTAAAATGAGAAACTAAGACCA
ATTTCTGTTTTTAAGAGGAAAAAGAATGATTGATGTATCCTAAGTATTGTTATTTGTTGTCTTTTTTTGCTGCCTTGCTTGAGTTGCTTG

>74802_74802_2_RNF13-TM4SF4_RNF13_chr3_149570383_ENST00000392894_TM4SF4_chr3_149193610_ENST00000305354_length(amino acids)=209AA_BP=65
MLLSIGMLMLSATQVYTILTVQLFAFLNLLPVEADILAYNFENASQTFDDLPARFGYRLPAEGLKMIFPALVFLGLKNNDCCGCCGNEGC
GKRFAMFTSTIFAVVGFLGAGYSFIISAISINKGPKCLMANSTWGYPFHDGDYLNDEALWNKCREPLNVVPWNLTLFSILLVVGGIQMVL

--------------------------------------------------------------
>74802_74802_3_RNF13-TM4SF4_RNF13_chr3_149589941_ENST00000344229_TM4SF4_chr3_149205406_ENST00000305354_length(transcript)=1956nt_BP=1023nt
CCCGCCCGGGGGCAGCCCGGCAGCCGAATCTTGGGCTACTCTGTCCCAACAGCCGGAGCAGATCAGACCGACCGGCCCTGCCCGCTCGGT
CCCGCGCCCTCCAGACCCTACGGTCTCCGTTTCTAGGGGCACATGGTTAGCGGCAGGCGCCCACAGCCAATCCACTTTGCCAGCCTGCCC
CTTCCTCTGCCAAGAGCAGCTTCTTCAGCCGCGCTCCAGTTCCGCAGACGCCTGCCCCACCCTGCTCTTCCCTTCCAGGGAAGACGGATC
ACGCGGCCAAGAACGAGACTCGCAAACTGGGCATTTCTCCGAGCCGGGCTAGAGCAAGTAGCGAGACTCCGCGTGAGAGTGGGAAAGAGC
CTTAACAGGCAACCATGTTGCCCAGTGGGTTTTCTGTGCCTTTGGGTGCGGACCAATGAGGCGCGTGGGGCGGGACTTCCGCTTCGCCTA
GGTGTTGTCGTCCCTGCTAGTACTCCGGGCTGTGGGGGTCGGTGCGGATATTCAGTCATGAAATCAGGGTAGGGACTTCTCCCGCAGCGA
CGCGGCTGGCAAGACTGTTTGTGTTGCGGGGGCCGGACTTCAAGAGAGAAAGAGAGAGTGGGCAGACATCGAAGCCAAACAGCAGTATCC
CGGAAGCACTCATGCAACTTTGGTGGCGGCCACTCAGTTTTCTCTGCCAGTGTCTGGTGATTTTACAACGAGATGCTGCTCTCCATAGGG
ATGCTCATGCTGTCAGCCACACAAGTCTACACCATCTTGACTGTCCAGCTCTTTGCATTCTTAAACCTACTGCCTGTAGAAGCAGACATT
TTAGCATATAACTTTGAAAATGCATCTCAGACATTTGATGACCTCCCTGCAAGATTTGGTTATAGACTTCCAGCTGAAGGTTTAAAGGGT
TTTTTGATTAACTCAAAACCAGAGAATGCCTGTGAACCCATAGTGCCTCCACCAGTAAAAGACAATTCATCTGGCACTTTCATCGTGTTA
ATTAGAAGACTTGATTGTAATTTTGATATAAAGATGTTCACCTCCACGATATTTGCTGTGGTTGGATTCTTGGGAGCTGGATACTCGTTT
ATCATCTCAGCCATTTCAATCAACAAGGGTCCTAAATGCCTCATGGCCAATAGTACATGGGGCTACCCCTTCCACGACGGGGATTATCTC
AATGATGAGGCCTTATGGAACAAGTGCCGAGAGCCTCTCAATGTGGTTCCCTGGAATCTGACCCTCTTCTCCATCCTGCTGGTCGTAGGA
GGAATCCAGATGGTTCTCTGCGCCATCCAGGTGGTCAATGGCCTCCTGGGGACCCTCTGTGGGGACTGCCAGTGTTGTGGCTGCTGTGGG
GGAGATGGACCCGTTTAAACCTCCGAGATGAGCTGCTCAGACTCTACAGCATGACGACTACAATTTCTTTTCATAAAACTTCTTCTCTTC
TTGGAATTATTAATTCCTATCTGCTTCCTAGCTGATAAAGCTTAGAAAAGGCAGTTATTCCTTCTTTCCAACCAGCTTTGCTCGAGTTAG
AATTTTGTTATTTTCAAATAAAAAATAGTTTGGCCACTTAACAAATTTGATTTATAAATCTTTCAAATTAGTTCCTTTTTAGAATTTACC
AACAGGTTCAAAGCATACTTTTCATGATTTTTTTATTACAAATGTAAAATGTATAAAGTCACATGTACTGCCATACTACTTCTTTGTATA
TAAAGATGTTTATATCTTTGGAAGTTTTACATAAATCAAAGGAAGAAAGCACATTTAAAATGAGAAACTAAGACCAATTTCTGTTTTTAA
GAGGAAAAAGAATGATTGATGTATCCTAAGTATTGTTATTTGTTGTCTTTTTTTGCTGCCTTGCTTGAGTTGCTTGTGACTGATCTTTTG

>74802_74802_3_RNF13-TM4SF4_RNF13_chr3_149589941_ENST00000344229_TM4SF4_chr3_149205406_ENST00000305354_length(amino acids)=221AA_BP=107
MLLSIGMLMLSATQVYTILTVQLFAFLNLLPVEADILAYNFENASQTFDDLPARFGYRLPAEGLKGFLINSKPENACEPIVPPPVKDNSS
GTFIVLIRRLDCNFDIKMFTSTIFAVVGFLGAGYSFIISAISINKGPKCLMANSTWGYPFHDGDYLNDEALWNKCREPLNVVPWNLTLFS

--------------------------------------------------------------
>74802_74802_4_RNF13-TM4SF4_RNF13_chr3_149589941_ENST00000392894_TM4SF4_chr3_149205406_ENST00000305354_length(transcript)=1916nt_BP=983nt
CTCTTTAGTAGGTCGGGTGAGTGTAGTGTGCAGGGAAGAGACGCGTCAGCGCCAGGGCCAGGCCCGCCCGGGGGCAGCCCGGCAGCCGAA
TCTTGGGCTACTCTGTCCCAACAGCCGGAGCAGATCAGACCGACCGGCCCTGCCCGCTCGGTCCCGCGCCCTCCAGACCCTACGGTCTCC
GTTTCTAGGGGCACATGGTTAGCGGCAGGCGCCCACAGCCAATCCACTTTGCCAGCCTGCCCCTTCCTCTGCCAAGAGCAGCTTCTTCAG
CCGCGCTCCAGTTCCGCAGACGCCTGCCCCACCCTGCTCTTCCCTTCCAGGGAAGACGGATCACGCGGCCAAGAACGAGACTCGCAAACT
GGGCATTTCTCCGAGCCGGGCTAGAGCAAGTAGCGAGACTCCGCGTGAGAGTGGGAAAGAGCCTTAACAGGCAACCATGTTGCCCAGTGG
GTTTTCTGTGCCTTTGGGTGCGGACCAATGAGGCGCGTGGGGCGGGACTTCCGCTTCGCCTAGGTGTTGTCGTCCCTGCTAGTACTCCGG
GCTGTGGGGGTCGGTGCGGATATTCAGTCATGAAATCAGGGTAGGGACTTCTCCCGCAGCGACGCGGCTGGCAAGACTGTTTGTGTTGCG
GGGGCCGGACTTCAAGGTGATTTTACAACGAGATGCTGCTCTCCATAGGGATGCTCATGCTGTCAGCCACACAAGTCTACACCATCTTGA
CTGTCCAGCTCTTTGCATTCTTAAACCTACTGCCTGTAGAAGCAGACATTTTAGCATATAACTTTGAAAATGCATCTCAGACATTTGATG
ACCTCCCTGCAAGATTTGGTTATAGACTTCCAGCTGAAGGTTTAAAGGGTTTTTTGATTAACTCAAAACCAGAGAATGCCTGTGAACCCA
TAGTGCCTCCACCAGTAAAAGACAATTCATCTGGCACTTTCATCGTGTTAATTAGAAGACTTGATTGTAATTTTGATATAAAGATGTTCA
CCTCCACGATATTTGCTGTGGTTGGATTCTTGGGAGCTGGATACTCGTTTATCATCTCAGCCATTTCAATCAACAAGGGTCCTAAATGCC
TCATGGCCAATAGTACATGGGGCTACCCCTTCCACGACGGGGATTATCTCAATGATGAGGCCTTATGGAACAAGTGCCGAGAGCCTCTCA
ATGTGGTTCCCTGGAATCTGACCCTCTTCTCCATCCTGCTGGTCGTAGGAGGAATCCAGATGGTTCTCTGCGCCATCCAGGTGGTCAATG
GCCTCCTGGGGACCCTCTGTGGGGACTGCCAGTGTTGTGGCTGCTGTGGGGGAGATGGACCCGTTTAAACCTCCGAGATGAGCTGCTCAG
ACTCTACAGCATGACGACTACAATTTCTTTTCATAAAACTTCTTCTCTTCTTGGAATTATTAATTCCTATCTGCTTCCTAGCTGATAAAG
CTTAGAAAAGGCAGTTATTCCTTCTTTCCAACCAGCTTTGCTCGAGTTAGAATTTTGTTATTTTCAAATAAAAAATAGTTTGGCCACTTA
ACAAATTTGATTTATAAATCTTTCAAATTAGTTCCTTTTTAGAATTTACCAACAGGTTCAAAGCATACTTTTCATGATTTTTTTATTACA
AATGTAAAATGTATAAAGTCACATGTACTGCCATACTACTTCTTTGTATATAAAGATGTTTATATCTTTGGAAGTTTTACATAAATCAAA
GGAAGAAAGCACATTTAAAATGAGAAACTAAGACCAATTTCTGTTTTTAAGAGGAAAAAGAATGATTGATGTATCCTAAGTATTGTTATT
TGTTGTCTTTTTTTGCTGCCTTGCTTGAGTTGCTTGTGACTGATCTTTTGAGGCTGTCATCATGGCTAGGGTTCTTTTATGTATGTTAAA

>74802_74802_4_RNF13-TM4SF4_RNF13_chr3_149589941_ENST00000392894_TM4SF4_chr3_149205406_ENST00000305354_length(amino acids)=221AA_BP=107
MLLSIGMLMLSATQVYTILTVQLFAFLNLLPVEADILAYNFENASQTFDDLPARFGYRLPAEGLKGFLINSKPENACEPIVPPPVKDNSS
GTFIVLIRRLDCNFDIKMFTSTIFAVVGFLGAGYSFIISAISINKGPKCLMANSTWGYPFHDGDYLNDEALWNKCREPLNVVPWNLTLFS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RNF13-TM4SF4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RNF13-TM4SF4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RNF13-TM4SF4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource