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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RNF144B-DEK (FusionGDB2 ID:74815)

Fusion Gene Summary for RNF144B-DEK

check button Fusion gene summary
Fusion gene informationFusion gene name: RNF144B-DEK
Fusion gene ID: 74815
HgeneTgene
Gene symbol

RNF144B

DEK

Gene ID

255488

7913

Gene namering finger protein 144BDEK proto-oncogene
SynonymsIBRDC2|PIR2|bA528A10.3|p53RFPD6S231E
Cytomap

6p22.3

6p22.3

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase RNF144BIBR domain containing 2IBR domain-containing protein 2p53-inducible RING finger proteinprotein DEKDEK oncogene (DNA binding)
Modification date2020031320200313
UniProtAcc.

P35659

Ensembl transtripts involved in fusion geneENST00000486622, ENST00000259939, 
ENST00000429054, 
ENST00000244776, 
ENST00000397239, 
Fusion gene scores* DoF score11 X 5 X 7=3855 X 9 X 3=135
# samples 99
** MAII scorelog2(9/385*10)=-2.09686153925259
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/135*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RNF144B [Title/Abstract] AND DEK [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRNF144B(18399930)-DEK(18237747), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRNF144B

GO:0006511

ubiquitin-dependent protein catabolic process

12853982

HgeneRNF144B

GO:0043066

negative regulation of apoptotic process

20300062


check buttonFusion gene breakpoints across RNF144B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DEK (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4THCATCGA-BJ-A28VRNF144Bchr6

18399930

+DEKchr6

18237747

-


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Fusion Gene ORF analysis for RNF144B-DEK

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000486622ENST00000244776RNF144Bchr6

18399930

+DEKchr6

18237747

-
3UTR-3CDSENST00000486622ENST00000397239RNF144Bchr6

18399930

+DEKchr6

18237747

-
In-frameENST00000259939ENST00000244776RNF144Bchr6

18399930

+DEKchr6

18237747

-
In-frameENST00000259939ENST00000397239RNF144Bchr6

18399930

+DEKchr6

18237747

-
intron-3CDSENST00000429054ENST00000244776RNF144Bchr6

18399930

+DEKchr6

18237747

-
intron-3CDSENST00000429054ENST00000397239RNF144Bchr6

18399930

+DEKchr6

18237747

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000259939RNF144Bchr618399930+ENST00000397239DEKchr618237747-2699482215847210
ENST00000259939RNF144Bchr618399930+ENST00000244776DEKchr618237747-1097482215847210

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000259939ENST00000397239RNF144Bchr618399930+DEKchr618237747-0.0019039140.99809605
ENST00000259939ENST00000244776RNF144Bchr618399930+DEKchr618237747-0.0033911140.99660885

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Fusion Genomic Features for RNF144B-DEK


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RNF144B-DEK


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:18399930/chr6:18237747)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DEK

P35659

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Involved in chromatin organization. {ECO:0000269|PubMed:17524367}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDEKchr6:18399930chr6:18237747ENST00000244776510228_236220342.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneDEKchr6:18399930chr6:18237747ENST00000244776510241_254220342.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneDEKchr6:18399930chr6:18237747ENST00000244776510300_310220342.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneDEKchr6:18399930chr6:18237747ENST00000397239611300_310254376.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneDEKchr6:18399930chr6:18237747ENST00000244776510337_351220342.0DNA binding.
TgeneDEKchr6:18399930chr6:18237747ENST00000244776510367_371220342.0DNA binding.
TgeneDEKchr6:18399930chr6:18237747ENST00000397239611337_351254376.0DNA binding.
TgeneDEKchr6:18399930chr6:18237747ENST00000397239611367_371254376.0DNA binding.

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRNF144Bchr6:18399930chr6:18237747ENST00000259939+2826_24455304.0RegionTRIAD supradomain
HgeneRNF144Bchr6:18399930chr6:18237747ENST00000259939+28258_27855304.0TransmembraneHelical
HgeneRNF144Bchr6:18399930chr6:18237747ENST00000259939+28101_16655304.0Zinc fingerIBR-type
HgeneRNF144Bchr6:18399930chr6:18237747ENST00000259939+28193_22255304.0Zinc fingerRING-type 2%3B atypical
HgeneRNF144Bchr6:18399930chr6:18237747ENST00000259939+2830_8055304.0Zinc fingerRING-type 1
TgeneDEKchr6:18399930chr6:18237747ENST0000024477651030_49220342.0Compositional biasNote=Asp/Glu-rich (highly acidic)
TgeneDEKchr6:18399930chr6:18237747ENST00000397239611228_236254376.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneDEKchr6:18399930chr6:18237747ENST00000397239611241_254254376.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneDEKchr6:18399930chr6:18237747ENST0000039723961130_49254376.0Compositional biasNote=Asp/Glu-rich (highly acidic)
TgeneDEKchr6:18399930chr6:18237747ENST00000244776510149_183220342.0DomainNote=SAP
TgeneDEKchr6:18399930chr6:18237747ENST00000397239611149_183254376.0DomainNote=SAP
TgeneDEKchr6:18399930chr6:18237747ENST00000244776510205_221220342.0MotifNuclear localization signal
TgeneDEKchr6:18399930chr6:18237747ENST00000397239611205_221254376.0MotifNuclear localization signal


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Fusion Gene Sequence for RNF144B-DEK


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>74815_74815_1_RNF144B-DEK_RNF144B_chr6_18399930_ENST00000259939_DEK_chr6_18237747_ENST00000244776_length(transcript)=1097nt_BP=482nt
GAGCTGTGCCCCACGCTCCCGCTGCAACAGTCCCGGGCATCGCAGCTGCCAGTCAAGGCTAGGAGGCGGTCGGGGACTCCGCCTCCTCCC
GACCCGTAGGTCTGGGAGCGCAAGTCCTGTTGCAGTCTTGCAAAGTGTAAAGCTGTCAGCCGCAGAGCACGGAGGAAAGACGGAGAGAAT
GGAAGAGCTCCTGTCCGGTGTGCCAGCAGCCCGGACTGGCGGTGAGCGCGAGGGAGGCTACTGAGAAGCCCGGCGACGGAGGAACGCAGG
TCTGCTGCCAGGGATTGAGGAGACTGAAGAATGCTGAAGACAGGCTGATGGGCTCAGCTGGTAGGCTCCACTATCTCGCCATGACTGCTG
AAAATCCCACTCCTGGAGACCTGGCTCCGGCCCCCCTCATCACTTGCAAACTCTGCCTGTGTGAGCAGTCTCTGGACAAGATGACCACAC
TCCAGGAATGCCAGTGCATCTTTTGCACAGCTCCACCAAAAAAGACAGCCAAAAGAGAAAAACCTAAACAGAAAGCTACTTCTAAAAGTA
AAAAATCTGTGAAAAGTGCCAATGTTAAGAAAGCAGATAGCAGCACCACCAAGAAGAATCAAAACAGTTCCAAAAAAGAAAGTGAGTCTG
AGGATAGTTCAGATGATGAACCTTTAATTAAAAAGTTGAAGAAACCCCCTACAGATGAAGAGTTAAAGGAAACAATAAAGAAATTACTGG
CCAGTGCTAACTTGGAAGAAGTCACAATGAAACAGATTTGCAAAAAGGTCTATGAAAATTATCCTACTTATGATTTAACTGAAAGAAAAG
ATTTCATAAAAACAACTGTAAAAGAGCTAATTTCTTGAGATAGAGGACAGAGAAGATGACTCGTTCCCATAGATTTGAAGATCTGATTTA
TACCATTATACCAGCAAAGAGAATGTATTTCCTTTTCTAAATCCTTGTTAAGCAACGTTAGTAGAACTTACTGCTGACCTTTTTATCTTG
AGTGTTATGTGAATTTGAGTTTGCTGTTTTAAATTGCATTTCTATGCCATTTTTAGTTTAAAATCTTGCATGGCATTAATTGTTCCTTGC

>74815_74815_1_RNF144B-DEK_RNF144B_chr6_18399930_ENST00000259939_DEK_chr6_18237747_ENST00000244776_length(amino acids)=210AA_BP=89
MAVSAREATEKPGDGGTQVCCQGLRRLKNAEDRLMGSAGRLHYLAMTAENPTPGDLAPAPLITCKLCLCEQSLDKMTTLQECQCIFCTAP
PKKTAKREKPKQKATSKSKKSVKSANVKKADSSTTKKNQNSSKKESESEDSSDDEPLIKKLKKPPTDEELKETIKKLLASANLEEVTMKQ

--------------------------------------------------------------
>74815_74815_2_RNF144B-DEK_RNF144B_chr6_18399930_ENST00000259939_DEK_chr6_18237747_ENST00000397239_length(transcript)=2699nt_BP=482nt
GAGCTGTGCCCCACGCTCCCGCTGCAACAGTCCCGGGCATCGCAGCTGCCAGTCAAGGCTAGGAGGCGGTCGGGGACTCCGCCTCCTCCC
GACCCGTAGGTCTGGGAGCGCAAGTCCTGTTGCAGTCTTGCAAAGTGTAAAGCTGTCAGCCGCAGAGCACGGAGGAAAGACGGAGAGAAT
GGAAGAGCTCCTGTCCGGTGTGCCAGCAGCCCGGACTGGCGGTGAGCGCGAGGGAGGCTACTGAGAAGCCCGGCGACGGAGGAACGCAGG
TCTGCTGCCAGGGATTGAGGAGACTGAAGAATGCTGAAGACAGGCTGATGGGCTCAGCTGGTAGGCTCCACTATCTCGCCATGACTGCTG
AAAATCCCACTCCTGGAGACCTGGCTCCGGCCCCCCTCATCACTTGCAAACTCTGCCTGTGTGAGCAGTCTCTGGACAAGATGACCACAC
TCCAGGAATGCCAGTGCATCTTTTGCACAGCTCCACCAAAAAAGACAGCCAAAAGAGAAAAACCTAAACAGAAAGCTACTTCTAAAAGTA
AAAAATCTGTGAAAAGTGCCAATGTTAAGAAAGCAGATAGCAGCACCACCAAGAAGAATCAAAACAGTTCCAAAAAAGAAAGTGAGTCTG
AGGATAGTTCAGATGATGAACCTTTAATTAAAAAGTTGAAGAAACCCCCTACAGATGAAGAGTTAAAGGAAACAATAAAGAAATTACTGG
CCAGTGCTAACTTGGAAGAAGTCACAATGAAACAGATTTGCAAAAAGGTCTATGAAAATTATCCTACTTATGATTTAACTGAAAGAAAAG
ATTTCATAAAAACAACTGTAAAAGAGCTAATTTCTTGAGATAGAGGACAGAGAAGATGACTCGTTCCCATAGATTTGAAGATCTGATTTA
TACCATTATACCAGCAAAGAGAATGTATTTCCTTTTCTAAATCCTTGTTAAGCAACGTTAGTAGAACTTACTGCTGACCTTTTTATCTTG
AGTGTTATGTGAATTTGAGTTTGCTGTTTTAAATTGCATTTCTATGCCATTTTTAGTTTAAAATCTTGCATGGCATTAATTGTTCCTTGC
TTTTATAGTTGTATTTTGTACATTTTGGATTTCTTTATATAAGGTCATAGATTCTTGAGCTGTTGTGGTTTTTAGTGCACTTAATATTAG
CTTGCTTAAGGCATACTTTTAATCAAGTAGAACAAAAACTATTATCACCAGGATTTATACATACAGAGATTGTAGTATTTAGTATATGAA
ATATTTTGAATACACATCTCTGTCAGTGTGAAAATTCAGCGGCAGTGTGTCCATCATATTAAAAATATACAAGCTACAGTTGTCCAGATC
ACTGAATTGGAACTTTTCTCCTGCATGTGTATATATGTCAAATTGTCAGCATGACAAAAGTGACAGATGTTATTTTTGTATTTTTAAAAA
ACAATTGGTTGTATATAAAGTTTTTTTATTTCTTTTGTGCAGATCACTTTTTAAACTCACATAGGTAGGTATCTTTATAGTTGTAGACTA
TGGAATGTCAGTGTTCAGCCAAACAGTATGATGGAACAGTGAAAGTCAATTCAGTGATGGCAACACTGAAGGAACAGTTACCCTGCTTTG
CCTCGAAAGTGTCATCAATTTGTAATTTTAGTATTAACTCTGTAAAAGTGTCTGTAGGTACGTTTTATATTATATAAGGACAGACCAAAA
ATCAACCTATCAAAGCTTCAAAAACTTTGGGAAAGGGTGGGATTAAGTACAAGCACATTTGGCTTACAGTAAATGAACTGATTTTTATTA
ACTGCTTTTGCCCATATAAAATGCTGATATTTACTGGAAACCTAGCCAGCTTCACGATTATGACTAAAGTACCAGATTATAATGCCAGAA
TATAATGTGCAGGCAATCGTGGATGTCTCTGACAAAGTGTGTCTCAAAAATAATATACTTTTACATTAAAGAAATTTAATGTTTCTCTGG
AGTTGGGGCTCTTGGCTTTCAGAGTTTGGTTAATCAGTGTTGATTCTAGATGATCAACATAATGGACCACTCCTGAATGAGACTTAATTT
TGTCTTTCAAATTTACTGTCTTAAATCAGTTTATTAAATCTGAATTTTAAAACATGCTGTTTATGACACAATGACACATTTGTTGCACCA
ATTAAGTGTTGAAAAATATCTTTGCATCATAGAACAGAAATATATAAAAATATATGTTGAATGTTAACAGGTATTTTCACAGGTTTGTTT
CTTGATAGTTACTCAGACACTAGGGAAAGGTAAATACAAGTGAACAAAATAAGCAACTAAATGAGACCTAATAATTGGCCTTCGATTTTA
AATATTTGTTCTTATAAACCTTGTCAATAAAAATAAATCTAAATCACTGGTGTTTTAAGTCACTTGCATTTGATATCTTATAGGTGTATA
TAGCATTTCCTTATGGGGAATAATTCTGAAAAGGGATTTTTAAATTGATTCAGCCCTATAACCTATACAATTTGGAATACTCTTTTGTGG
TAATGGACCATTTTCTTGGAGTGACTTCACAAAACTGAATAATTAAGGTTAATTTTATGACCATTTGCTATAAAGAAGGTAAGTAGTCAT

>74815_74815_2_RNF144B-DEK_RNF144B_chr6_18399930_ENST00000259939_DEK_chr6_18237747_ENST00000397239_length(amino acids)=210AA_BP=89
MAVSAREATEKPGDGGTQVCCQGLRRLKNAEDRLMGSAGRLHYLAMTAENPTPGDLAPAPLITCKLCLCEQSLDKMTTLQECQCIFCTAP
PKKTAKREKPKQKATSKSKKSVKSANVKKADSSTTKKNQNSSKKESESEDSSDDEPLIKKLKKPPTDEELKETIKKLLASANLEEVTMKQ

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Fusion Gene PPI Analysis for RNF144B-DEK


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RNF144B-DEK


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RNF144B-DEK


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource