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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RNF170-ADAM32 (FusionGDB2 ID:74887)

Fusion Gene Summary for RNF170-ADAM32

check button Fusion gene summary
Fusion gene informationFusion gene name: RNF170-ADAM32
Fusion gene ID: 74887
HgeneTgene
Gene symbol

RNF170

ADAM32

Gene ID

81790

203102

Gene namering finger protein 170ADAM metallopeptidase domain 32
SynonymsADSA|SNAX1-
Cytomap

8p11.21

8p11.22

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase RNF170RING-type E3 ubiquitin transferase RNF170putative LAG1-interacting proteindisintegrin and metalloproteinase domain-containing protein 32a disintegrin and metalloprotease domain 32a disintegrin and metalloproteinase domain 32metalloproteinase 12-like proteintesticular tissue protein Li 13
Modification date2020031320200313
UniProtAcc.

Q8TC27

Ensembl transtripts involved in fusion geneENST00000319104, ENST00000527424, 
ENST00000534961, ENST00000319073, 
ENST00000526349, 
ENST00000524303, 
ENST00000379907, ENST00000437682, 
ENST00000519315, 
Fusion gene scores* DoF score9 X 6 X 6=32411 X 12 X 8=1056
# samples 1013
** MAII scorelog2(10/324*10)=-1.6959938131099
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(13/1056*10)=-3.02202630633
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RNF170 [Title/Abstract] AND ADAM32 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRNF170(42742871)-ADAM32(39079129), # samples:3
Anticipated loss of major functional domain due to fusion event.RNF170-ADAM32 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across RNF170 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ADAM32 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-CM-6166-01ARNF170chr8

42742871

-ADAM32chr8

39079129

+


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Fusion Gene ORF analysis for RNF170-ADAM32

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000319104ENST00000524303RNF170chr8

42742871

-ADAM32chr8

39079129

+
5CDS-intronENST00000527424ENST00000524303RNF170chr8

42742871

-ADAM32chr8

39079129

+
5CDS-intronENST00000534961ENST00000524303RNF170chr8

42742871

-ADAM32chr8

39079129

+
5UTR-3CDSENST00000319073ENST00000379907RNF170chr8

42742871

-ADAM32chr8

39079129

+
5UTR-3CDSENST00000319073ENST00000437682RNF170chr8

42742871

-ADAM32chr8

39079129

+
5UTR-3CDSENST00000319073ENST00000519315RNF170chr8

42742871

-ADAM32chr8

39079129

+
5UTR-intronENST00000319073ENST00000524303RNF170chr8

42742871

-ADAM32chr8

39079129

+
Frame-shiftENST00000534961ENST00000379907RNF170chr8

42742871

-ADAM32chr8

39079129

+
Frame-shiftENST00000534961ENST00000437682RNF170chr8

42742871

-ADAM32chr8

39079129

+
Frame-shiftENST00000534961ENST00000519315RNF170chr8

42742871

-ADAM32chr8

39079129

+
In-frameENST00000319104ENST00000379907RNF170chr8

42742871

-ADAM32chr8

39079129

+
In-frameENST00000319104ENST00000437682RNF170chr8

42742871

-ADAM32chr8

39079129

+
In-frameENST00000319104ENST00000519315RNF170chr8

42742871

-ADAM32chr8

39079129

+
In-frameENST00000527424ENST00000379907RNF170chr8

42742871

-ADAM32chr8

39079129

+
In-frameENST00000527424ENST00000437682RNF170chr8

42742871

-ADAM32chr8

39079129

+
In-frameENST00000527424ENST00000519315RNF170chr8

42742871

-ADAM32chr8

39079129

+
intron-3CDSENST00000526349ENST00000379907RNF170chr8

42742871

-ADAM32chr8

39079129

+
intron-3CDSENST00000526349ENST00000437682RNF170chr8

42742871

-ADAM32chr8

39079129

+
intron-3CDSENST00000526349ENST00000519315RNF170chr8

42742871

-ADAM32chr8

39079129

+
intron-intronENST00000526349ENST00000524303RNF170chr8

42742871

-ADAM32chr8

39079129

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000319104RNF170chr842742871-ENST00000437682ADAM32chr839079129+14872462881376362
ENST00000319104RNF170chr842742871-ENST00000519315ADAM32chr839079129+13312462881220310
ENST00000319104RNF170chr842742871-ENST00000379907ADAM32chr839079129+14872462881376362
ENST00000527424RNF170chr842742871-ENST00000437682ADAM32chr839079129+16233824241512362
ENST00000527424RNF170chr842742871-ENST00000519315ADAM32chr839079129+14673824241356310
ENST00000527424RNF170chr842742871-ENST00000379907ADAM32chr839079129+16233824241512362

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000319104ENST00000437682RNF170chr842742871-ADAM32chr839079129+0.058722330.9412776
ENST00000319104ENST00000519315RNF170chr842742871-ADAM32chr839079129+0.259652730.7403473
ENST00000319104ENST00000379907RNF170chr842742871-ADAM32chr839079129+0.058722330.9412776
ENST00000527424ENST00000437682RNF170chr842742871-ADAM32chr839079129+0.0281128830.97188705
ENST00000527424ENST00000519315RNF170chr842742871-ADAM32chr839079129+0.122442630.8775574
ENST00000527424ENST00000379907RNF170chr842742871-ADAM32chr839079129+0.0281128830.97188705

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Fusion Genomic Features for RNF170-ADAM32


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RNF170chr842742870-ADAM32chr839079128+0.0003191030.9996809
RNF170chr842742870-ADAM32chr839079128+0.0003191030.9996809

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for RNF170-ADAM32


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:42742871/chr8:39079129)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ADAM32

Q8TC27

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: May play a role in sperm development and fertilization This is a non-catalytic metalloprotease-like protein. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRNF170chr8:42742871chr8:39079129ENST00000319104-261_2445201.0Topological domainLumenal
HgeneRNF170chr8:42742871chr8:39079129ENST00000527424-271_2445259.0Topological domainLumenal
HgeneRNF170chr8:42742871chr8:39079129ENST00000534961-271_2445259.0Topological domainLumenal
HgeneRNF170chr8:42742871chr8:39079129ENST00000319104-2625_4545201.0TransmembraneHelical
HgeneRNF170chr8:42742871chr8:39079129ENST00000527424-2725_4545259.0TransmembraneHelical
HgeneRNF170chr8:42742871chr8:39079129ENST00000534961-2725_4545259.0TransmembraneHelical
TgeneADAM32chr8:42742871chr8:39079129ENST000003799071125480_502411788.0Compositional biasNote=Cys-rich
TgeneADAM32chr8:42742871chr8:39079129ENST000003799071125622_654411788.0DomainEGF-like
TgeneADAM32chr8:42742871chr8:39079129ENST000003799071125704_787411788.0Topological domainCytoplasmic
TgeneADAM32chr8:42742871chr8:39079129ENST000003799071125683_703411788.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRNF170chr8:42742871chr8:39079129ENST00000319073-261_240163.0Topological domainLumenal
HgeneRNF170chr8:42742871chr8:39079129ENST00000319073-26223_2230163.0Topological domainLumenal
HgeneRNF170chr8:42742871chr8:39079129ENST00000319073-26245_2580163.0Topological domainCytoplasmic
HgeneRNF170chr8:42742871chr8:39079129ENST00000319073-2646_2010163.0Topological domainCytoplasmic
HgeneRNF170chr8:42742871chr8:39079129ENST00000319104-26223_22345201.0Topological domainLumenal
HgeneRNF170chr8:42742871chr8:39079129ENST00000319104-26245_25845201.0Topological domainCytoplasmic
HgeneRNF170chr8:42742871chr8:39079129ENST00000319104-2646_20145201.0Topological domainCytoplasmic
HgeneRNF170chr8:42742871chr8:39079129ENST00000526349-171_240175.0Topological domainLumenal
HgeneRNF170chr8:42742871chr8:39079129ENST00000526349-17223_2230175.0Topological domainLumenal
HgeneRNF170chr8:42742871chr8:39079129ENST00000526349-17245_2580175.0Topological domainCytoplasmic
HgeneRNF170chr8:42742871chr8:39079129ENST00000526349-1746_2010175.0Topological domainCytoplasmic
HgeneRNF170chr8:42742871chr8:39079129ENST00000527424-27223_22345259.0Topological domainLumenal
HgeneRNF170chr8:42742871chr8:39079129ENST00000527424-27245_25845259.0Topological domainCytoplasmic
HgeneRNF170chr8:42742871chr8:39079129ENST00000527424-2746_20145259.0Topological domainCytoplasmic
HgeneRNF170chr8:42742871chr8:39079129ENST00000534961-27223_22345259.0Topological domainLumenal
HgeneRNF170chr8:42742871chr8:39079129ENST00000534961-27245_25845259.0Topological domainCytoplasmic
HgeneRNF170chr8:42742871chr8:39079129ENST00000534961-2746_20145259.0Topological domainCytoplasmic
HgeneRNF170chr8:42742871chr8:39079129ENST00000319073-26202_2220163.0TransmembraneHelical
HgeneRNF170chr8:42742871chr8:39079129ENST00000319073-26224_2440163.0TransmembraneHelical
HgeneRNF170chr8:42742871chr8:39079129ENST00000319073-2625_450163.0TransmembraneHelical
HgeneRNF170chr8:42742871chr8:39079129ENST00000319104-26202_22245201.0TransmembraneHelical
HgeneRNF170chr8:42742871chr8:39079129ENST00000319104-26224_24445201.0TransmembraneHelical
HgeneRNF170chr8:42742871chr8:39079129ENST00000526349-17202_2220175.0TransmembraneHelical
HgeneRNF170chr8:42742871chr8:39079129ENST00000526349-17224_2440175.0TransmembraneHelical
HgeneRNF170chr8:42742871chr8:39079129ENST00000526349-1725_450175.0TransmembraneHelical
HgeneRNF170chr8:42742871chr8:39079129ENST00000527424-27202_22245259.0TransmembraneHelical
HgeneRNF170chr8:42742871chr8:39079129ENST00000527424-27224_24445259.0TransmembraneHelical
HgeneRNF170chr8:42742871chr8:39079129ENST00000534961-27202_22245259.0TransmembraneHelical
HgeneRNF170chr8:42742871chr8:39079129ENST00000534961-27224_24445259.0TransmembraneHelical
HgeneRNF170chr8:42742871chr8:39079129ENST00000319073-2687_1300163.0Zinc fingerRING-type
HgeneRNF170chr8:42742871chr8:39079129ENST00000319104-2687_13045201.0Zinc fingerRING-type
HgeneRNF170chr8:42742871chr8:39079129ENST00000526349-1787_1300175.0Zinc fingerRING-type
HgeneRNF170chr8:42742871chr8:39079129ENST00000527424-2787_13045259.0Zinc fingerRING-type
HgeneRNF170chr8:42742871chr8:39079129ENST00000534961-2787_13045259.0Zinc fingerRING-type
TgeneADAM32chr8:42742871chr8:39079129ENST000003799071125186_383411788.0DomainPeptidase M12B
TgeneADAM32chr8:42742871chr8:39079129ENST000003799071125391_479411788.0DomainDisintegrin
TgeneADAM32chr8:42742871chr8:39079129ENST000003799071125175_682411788.0Topological domainExtracellular


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Fusion Gene Sequence for RNF170-ADAM32


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>74887_74887_1_RNF170-ADAM32_RNF170_chr8_42742871_ENST00000319104_ADAM32_chr8_39079129_ENST00000379907_length(transcript)=1487nt_BP=246nt
GACGTCTAGTGGGTTGCCCGGGAGGGGTGGCGGGAGCGGTCCTGGAAATAATCTGTCCTCTGTCGCCGGGAACTGGCGAGGTAGTTCCTT
CGCGGTGGAGAGACCTGGAATGGCCAAATATCAAGGTGAAGTTCAAAGTTTGAAACTGGATGATGATTCAGTTATAGAAGGAGTAAGCGA
CCAAGTACTTGTGGCAGTTGTGGTCAGTTTCGCTTTGATTGCTACCCTGGTATATGCACTTTTCAGCAATGTGGACCTGCAAGCTGTTGT
GATTTTCGAACTTGTGTACTGAAAGACGGAGCAAAATGTTATAAAGGACTGTGCTGCAAAGACTGTCAAATTTTACAATCAGGCGTTGAA
TGTAGGCCGAAAGCACATCCTGAATGTGACATCGCTGAAAATTGTAATGGAACCTCACCAGAATGTGGTCCTGACATAACTTTAATCAAT
GGACTTTCATGCAAAAATAATAAGTTTATTTGTTATGACGGAGACTGCCATGATCTCGATGCACGTTGTGAGAGTGTATTTGGAAAAGGT
TCAAGAAATGCTCCATTTGCCTGCTATGAAGAAATACAATCTCAATCAGACAGATTTGGGAACTGTGGTAGGGATAGAAATAACAAATAT
GTGTTCTGTGGATGGAGGAATCTTATATGTGGAAGATTAGTTTGTACCTACCCTACTCGAAAGCCTTTCCATCAAGAAAATGGTGATGTG
ATTTATGCTTTCGTACGAGATTCTGTATGCATAACTGTAGACTACAAATTGCCTCGAACAGTTCCAGATCCACTGGCTGTCAAAAATGGC
TCTCAGTGTGATATTGGGAGGGTTTGTGTAAATCGTGAATGTGTAGAATCAAGGATAATTAAGGCTTCAGCACATGTTTGTTCACAACAG
TGTTCTGGACATGGAGTGTGTGATTCCAGAAACAAGTGCCATTGTTCGCCAGGCTATAAGCCTCCAAACTGCCAAATACGTTCCAAAGGA
TTTTCCATATTTCCTGAGGAAGATATGGGTTCAATCATGGAAAGAGCATCTGGGAAGACTGAAAACACCTGGCTTCTAGGTTTCCTCATT
GCTCTTCCTATTCTCATTGTAACAACCGCAATAGTTTTGGCAAGGAAACAGTTGAAAAAGTGGTTCGCCAAGGAAGAGGAATTCCCAAGT
AGCGAATCTAAATCGGAAGGTAGCACACAGACATATGCCAGCCAATCCAGCTCAGAAGGCAGCACTCAGACATATGCCAGCCAAACCAGA
TCAGAAAGCAGCAGTCAAGCTGATACTAGCAAATCCAAATCAGAAGATAGTGCTGAAGCATATACTAGCAGATCCAAATCACAGGACAGT
ACCCAAACACAAAGCAGTAGTAACTAGTGATTCCTTCAGAAGGCAACGGATAACATCGAGAGTCTCGCTAAGAAATGAAAATTCTGTCTT

>74887_74887_1_RNF170-ADAM32_RNF170_chr8_42742871_ENST00000319104_ADAM32_chr8_39079129_ENST00000379907_length(amino acids)=362AA_BP=
MKDGAKCYKGLCCKDCQILQSGVECRPKAHPECDIAENCNGTSPECGPDITLINGLSCKNNKFICYDGDCHDLDARCESVFGKGSRNAPF
ACYEEIQSQSDRFGNCGRDRNNKYVFCGWRNLICGRLVCTYPTRKPFHQENGDVIYAFVRDSVCITVDYKLPRTVPDPLAVKNGSQCDIG
RVCVNRECVESRIIKASAHVCSQQCSGHGVCDSRNKCHCSPGYKPPNCQIRSKGFSIFPEEDMGSIMERASGKTENTWLLGFLIALPILI
VTTAIVLARKQLKKWFAKEEEFPSSESKSEGSTQTYASQSSSEGSTQTYASQTRSESSSQADTSKSKSEDSAEAYTSRSKSQDSTQTQSS

--------------------------------------------------------------
>74887_74887_2_RNF170-ADAM32_RNF170_chr8_42742871_ENST00000319104_ADAM32_chr8_39079129_ENST00000437682_length(transcript)=1487nt_BP=246nt
GACGTCTAGTGGGTTGCCCGGGAGGGGTGGCGGGAGCGGTCCTGGAAATAATCTGTCCTCTGTCGCCGGGAACTGGCGAGGTAGTTCCTT
CGCGGTGGAGAGACCTGGAATGGCCAAATATCAAGGTGAAGTTCAAAGTTTGAAACTGGATGATGATTCAGTTATAGAAGGAGTAAGCGA
CCAAGTACTTGTGGCAGTTGTGGTCAGTTTCGCTTTGATTGCTACCCTGGTATATGCACTTTTCAGCAATGTGGACCTGCAAGCTGTTGT
GATTTTCGAACTTGTGTACTGAAAGACGGAGCAAAATGTTATAAAGGACTGTGCTGCAAAGACTGTCAAATTTTACAATCAGGCGTTGAA
TGTAGGCCGAAAGCACATCCTGAATGTGACATCGCTGAAAATTGTAATGGAACCTCACCAGAATGTGGTCCTGACATAACTTTAATCAAT
GGACTTTCATGCAAAAATAATAAGTTTATTTGTTATGACGGAGACTGCCATGATCTCGATGCACGTTGTGAGAGTGTATTTGGAAAAGGT
TCAAGAAATGCTCCATTTGCCTGCTATGAAGAAATACAATCTCAATCAGACAGATTTGGGAACTGTGGTAGGGATAGAAATAACAAATAT
GTGTTCTGTGGATGGAGGAATCTTATATGTGGAAGATTAGTTTGTACCTACCCTACTCGAAAGCCTTTCCATCAAGAAAATGGTGATGTG
ATTTATGCTTTCGTACGAGATTCTGTATGCATAACTGTAGACTACAAATTGCCTCGAACAGTTCCAGATCCACTGGCTGTCAAAAATGGC
TCTCAGTGTGATATTGGGAGGGTTTGTGTAAATCGTGAATGTGTAGAATCAAGGATAATTAAGGCTTCAGCACATGTTTGTTCACAACAG
TGTTCTGGACATGGAGTGTGTGATTCCAGAAACAAGTGCCATTGTTCGCCAGGCTATAAGCCTCCAAACTGCCAAATACGTTCCAAAGGA
TTTTCCATATTTCCTGAGGAAGATATGGGTTCAATCATGGAAAGAGCATCTGGGAAGACTGAAAACACCTGGCTTCTAGGTTTCCTCATT
GCTCTTCCTATTCTCATTGTAACAACCGCAATAGTTTTGGCAAGGAAACAGTTGAAAAAGTGGTTCGCCAAGGAAGAGGAATTCCCAAGT
AGCGAATCTAAATCGGAAGGTAGCACACAGACATATGCCAGCCAATCCAGCTCAGAAGGCAGCACTCAGACATATGCCAGCCAAACCAGA
TCAGAAAGCAGCAGTCAAGCTGATACTAGCAAATCCAAATCAGAAGATAGTGCTGAAGCATATACTAGCAGATCCAAATCACAGGACAGT
ACCCAAACACAAAGCAGTAGTAACTAGTGATTCCTTCAGAAGGCAACGGATAACATCGAGAGTCTCGCTAAGAAATGAAAATTCTGTCTT

>74887_74887_2_RNF170-ADAM32_RNF170_chr8_42742871_ENST00000319104_ADAM32_chr8_39079129_ENST00000437682_length(amino acids)=362AA_BP=
MKDGAKCYKGLCCKDCQILQSGVECRPKAHPECDIAENCNGTSPECGPDITLINGLSCKNNKFICYDGDCHDLDARCESVFGKGSRNAPF
ACYEEIQSQSDRFGNCGRDRNNKYVFCGWRNLICGRLVCTYPTRKPFHQENGDVIYAFVRDSVCITVDYKLPRTVPDPLAVKNGSQCDIG
RVCVNRECVESRIIKASAHVCSQQCSGHGVCDSRNKCHCSPGYKPPNCQIRSKGFSIFPEEDMGSIMERASGKTENTWLLGFLIALPILI
VTTAIVLARKQLKKWFAKEEEFPSSESKSEGSTQTYASQSSSEGSTQTYASQTRSESSSQADTSKSKSEDSAEAYTSRSKSQDSTQTQSS

--------------------------------------------------------------
>74887_74887_3_RNF170-ADAM32_RNF170_chr8_42742871_ENST00000319104_ADAM32_chr8_39079129_ENST00000519315_length(transcript)=1331nt_BP=246nt
GACGTCTAGTGGGTTGCCCGGGAGGGGTGGCGGGAGCGGTCCTGGAAATAATCTGTCCTCTGTCGCCGGGAACTGGCGAGGTAGTTCCTT
CGCGGTGGAGAGACCTGGAATGGCCAAATATCAAGGTGAAGTTCAAAGTTTGAAACTGGATGATGATTCAGTTATAGAAGGAGTAAGCGA
CCAAGTACTTGTGGCAGTTGTGGTCAGTTTCGCTTTGATTGCTACCCTGGTATATGCACTTTTCAGCAATGTGGACCTGCAAGCTGTTGT
GATTTTCGAACTTGTGTACTGAAAGACGGAGCAAAATGTTATAAAGGACTGTGCTGCAAAGACTGTCAAATTTTACAATCAGGCGTTGAA
TGTAGGCCGAAAGCACATCCTGAATGTGACATCGCTGAAAATTGTAATGGAACCTCACCAGAATGTGGTCCTGACATAACTTTAATCAAT
GGACTTTCATGCAAAAATAATAAGTTTATTTGTTATGACGGAGACTGCCATGATCTCGATGCACGTTGTGAGAGTGTATTTGGAAAAGGT
TCAAGAAATGCTCCATTTGCCTGCTATGAAGAAATACAATCTCAATCAGACAGATTTGGGAACTGTGGTAGGGATAGAAATAACAAATAT
GTGTTCTGTGGATGGAGGAATCTTATATGTGGAAGATTAGTTTGTACCTACCCTACTCGAAAGCCTTTCCATCAAGAAAATGGTGATGTG
ATTTATGCTTTCGTACGAGATTCTGTATGCATAACTGTAGACTACAAATTGCCTCGAACAGTTCCAGATCCACTGGCTGTCAAAAATGGC
TCTCAGTGTGATATTGGGAGGGTTTGTGTAAATCGTGAATGTGTAGAATCAAGGATAATTAAGGCTTCAGCACATGTTTGTTCACAACAG
TGTTCTGGACATGGAGTGTGTGATTCCAGAAACAAGTGCCATTGTTCGCCAGGCTATAAGCCTCCAAACTGCCAAATACGTTCCAAAGGA
TTTTCCATATTTCCTGAGGAAGATATGGGTTCAATCATGGAAAGAGCATCTGGGAAGACTGAAAACACCTGGCTTCTAGGTTTCCTCATT
GCTCTTCCTATTCTCATTGTAACAACCGCAATAGTTTTGGCAAGGAAACAGTTGAAAAAGTGGTTCGCCAAGGAAGAGGAATTCCCAAGT
AGCGAATCCAAATCACAGGACAGTACCCAAACACAAAGCAGTAGTAACTAGTGATTCCTTCAGAAGGCAACGGATAACATCGAGAGTCTC

>74887_74887_3_RNF170-ADAM32_RNF170_chr8_42742871_ENST00000319104_ADAM32_chr8_39079129_ENST00000519315_length(amino acids)=310AA_BP=
MKDGAKCYKGLCCKDCQILQSGVECRPKAHPECDIAENCNGTSPECGPDITLINGLSCKNNKFICYDGDCHDLDARCESVFGKGSRNAPF
ACYEEIQSQSDRFGNCGRDRNNKYVFCGWRNLICGRLVCTYPTRKPFHQENGDVIYAFVRDSVCITVDYKLPRTVPDPLAVKNGSQCDIG
RVCVNRECVESRIIKASAHVCSQQCSGHGVCDSRNKCHCSPGYKPPNCQIRSKGFSIFPEEDMGSIMERASGKTENTWLLGFLIALPILI

--------------------------------------------------------------
>74887_74887_4_RNF170-ADAM32_RNF170_chr8_42742871_ENST00000527424_ADAM32_chr8_39079129_ENST00000379907_length(transcript)=1623nt_BP=382nt
TTCGCTGCGTGTCGAGGCGAGCACGCGCTCCGCCCTGGAGGCTGCGGCGACGGGTCCTCCTCCGCCGTCCGGTCGCGCCCTCGCGGAAGC
TCGGCAGTGCGCGTGCGCCCGCACCCGCACTCCAAATTAGAAAGGGGACGTCTAGTGGGTTGCCCGGGAGGGGTGGCGGGAGCGGTCCTG
GAAATAATCTGTCCTCTGTCGCCGGGAACTGGCGAGGTAGTTCCTTCGCGGTGGAGAGACCTGGAATGGCCAAATATCAAGGTGAAGTTC
AAAGTTTGAAACTGGATGATGATTCAGTTATAGAAGGAGTAAGCGACCAAGTACTTGTGGCAGTTGTGGTCAGTTTCGCTTTGATTGCTA
CCCTGGTATATGCACTTTTCAGCAATGTGGACCTGCAAGCTGTTGTGATTTTCGAACTTGTGTACTGAAAGACGGAGCAAAATGTTATAA
AGGACTGTGCTGCAAAGACTGTCAAATTTTACAATCAGGCGTTGAATGTAGGCCGAAAGCACATCCTGAATGTGACATCGCTGAAAATTG
TAATGGAACCTCACCAGAATGTGGTCCTGACATAACTTTAATCAATGGACTTTCATGCAAAAATAATAAGTTTATTTGTTATGACGGAGA
CTGCCATGATCTCGATGCACGTTGTGAGAGTGTATTTGGAAAAGGTTCAAGAAATGCTCCATTTGCCTGCTATGAAGAAATACAATCTCA
ATCAGACAGATTTGGGAACTGTGGTAGGGATAGAAATAACAAATATGTGTTCTGTGGATGGAGGAATCTTATATGTGGAAGATTAGTTTG
TACCTACCCTACTCGAAAGCCTTTCCATCAAGAAAATGGTGATGTGATTTATGCTTTCGTACGAGATTCTGTATGCATAACTGTAGACTA
CAAATTGCCTCGAACAGTTCCAGATCCACTGGCTGTCAAAAATGGCTCTCAGTGTGATATTGGGAGGGTTTGTGTAAATCGTGAATGTGT
AGAATCAAGGATAATTAAGGCTTCAGCACATGTTTGTTCACAACAGTGTTCTGGACATGGAGTGTGTGATTCCAGAAACAAGTGCCATTG
TTCGCCAGGCTATAAGCCTCCAAACTGCCAAATACGTTCCAAAGGATTTTCCATATTTCCTGAGGAAGATATGGGTTCAATCATGGAAAG
AGCATCTGGGAAGACTGAAAACACCTGGCTTCTAGGTTTCCTCATTGCTCTTCCTATTCTCATTGTAACAACCGCAATAGTTTTGGCAAG
GAAACAGTTGAAAAAGTGGTTCGCCAAGGAAGAGGAATTCCCAAGTAGCGAATCTAAATCGGAAGGTAGCACACAGACATATGCCAGCCA
ATCCAGCTCAGAAGGCAGCACTCAGACATATGCCAGCCAAACCAGATCAGAAAGCAGCAGTCAAGCTGATACTAGCAAATCCAAATCAGA
AGATAGTGCTGAAGCATATACTAGCAGATCCAAATCACAGGACAGTACCCAAACACAAAGCAGTAGTAACTAGTGATTCCTTCAGAAGGC
AACGGATAACATCGAGAGTCTCGCTAAGAAATGAAAATTCTGTCTTTCCTTCCGTGGTCACAGCTGAAAGAAACAATAAATTGAGTGTGG

>74887_74887_4_RNF170-ADAM32_RNF170_chr8_42742871_ENST00000527424_ADAM32_chr8_39079129_ENST00000379907_length(amino acids)=362AA_BP=
MKDGAKCYKGLCCKDCQILQSGVECRPKAHPECDIAENCNGTSPECGPDITLINGLSCKNNKFICYDGDCHDLDARCESVFGKGSRNAPF
ACYEEIQSQSDRFGNCGRDRNNKYVFCGWRNLICGRLVCTYPTRKPFHQENGDVIYAFVRDSVCITVDYKLPRTVPDPLAVKNGSQCDIG
RVCVNRECVESRIIKASAHVCSQQCSGHGVCDSRNKCHCSPGYKPPNCQIRSKGFSIFPEEDMGSIMERASGKTENTWLLGFLIALPILI
VTTAIVLARKQLKKWFAKEEEFPSSESKSEGSTQTYASQSSSEGSTQTYASQTRSESSSQADTSKSKSEDSAEAYTSRSKSQDSTQTQSS

--------------------------------------------------------------
>74887_74887_5_RNF170-ADAM32_RNF170_chr8_42742871_ENST00000527424_ADAM32_chr8_39079129_ENST00000437682_length(transcript)=1623nt_BP=382nt
TTCGCTGCGTGTCGAGGCGAGCACGCGCTCCGCCCTGGAGGCTGCGGCGACGGGTCCTCCTCCGCCGTCCGGTCGCGCCCTCGCGGAAGC
TCGGCAGTGCGCGTGCGCCCGCACCCGCACTCCAAATTAGAAAGGGGACGTCTAGTGGGTTGCCCGGGAGGGGTGGCGGGAGCGGTCCTG
GAAATAATCTGTCCTCTGTCGCCGGGAACTGGCGAGGTAGTTCCTTCGCGGTGGAGAGACCTGGAATGGCCAAATATCAAGGTGAAGTTC
AAAGTTTGAAACTGGATGATGATTCAGTTATAGAAGGAGTAAGCGACCAAGTACTTGTGGCAGTTGTGGTCAGTTTCGCTTTGATTGCTA
CCCTGGTATATGCACTTTTCAGCAATGTGGACCTGCAAGCTGTTGTGATTTTCGAACTTGTGTACTGAAAGACGGAGCAAAATGTTATAA
AGGACTGTGCTGCAAAGACTGTCAAATTTTACAATCAGGCGTTGAATGTAGGCCGAAAGCACATCCTGAATGTGACATCGCTGAAAATTG
TAATGGAACCTCACCAGAATGTGGTCCTGACATAACTTTAATCAATGGACTTTCATGCAAAAATAATAAGTTTATTTGTTATGACGGAGA
CTGCCATGATCTCGATGCACGTTGTGAGAGTGTATTTGGAAAAGGTTCAAGAAATGCTCCATTTGCCTGCTATGAAGAAATACAATCTCA
ATCAGACAGATTTGGGAACTGTGGTAGGGATAGAAATAACAAATATGTGTTCTGTGGATGGAGGAATCTTATATGTGGAAGATTAGTTTG
TACCTACCCTACTCGAAAGCCTTTCCATCAAGAAAATGGTGATGTGATTTATGCTTTCGTACGAGATTCTGTATGCATAACTGTAGACTA
CAAATTGCCTCGAACAGTTCCAGATCCACTGGCTGTCAAAAATGGCTCTCAGTGTGATATTGGGAGGGTTTGTGTAAATCGTGAATGTGT
AGAATCAAGGATAATTAAGGCTTCAGCACATGTTTGTTCACAACAGTGTTCTGGACATGGAGTGTGTGATTCCAGAAACAAGTGCCATTG
TTCGCCAGGCTATAAGCCTCCAAACTGCCAAATACGTTCCAAAGGATTTTCCATATTTCCTGAGGAAGATATGGGTTCAATCATGGAAAG
AGCATCTGGGAAGACTGAAAACACCTGGCTTCTAGGTTTCCTCATTGCTCTTCCTATTCTCATTGTAACAACCGCAATAGTTTTGGCAAG
GAAACAGTTGAAAAAGTGGTTCGCCAAGGAAGAGGAATTCCCAAGTAGCGAATCTAAATCGGAAGGTAGCACACAGACATATGCCAGCCA
ATCCAGCTCAGAAGGCAGCACTCAGACATATGCCAGCCAAACCAGATCAGAAAGCAGCAGTCAAGCTGATACTAGCAAATCCAAATCAGA
AGATAGTGCTGAAGCATATACTAGCAGATCCAAATCACAGGACAGTACCCAAACACAAAGCAGTAGTAACTAGTGATTCCTTCAGAAGGC
AACGGATAACATCGAGAGTCTCGCTAAGAAATGAAAATTCTGTCTTTCCTTCCGTGGTCACAGCTGAAAGAAACAATAAATTGAGTGTGG

>74887_74887_5_RNF170-ADAM32_RNF170_chr8_42742871_ENST00000527424_ADAM32_chr8_39079129_ENST00000437682_length(amino acids)=362AA_BP=
MKDGAKCYKGLCCKDCQILQSGVECRPKAHPECDIAENCNGTSPECGPDITLINGLSCKNNKFICYDGDCHDLDARCESVFGKGSRNAPF
ACYEEIQSQSDRFGNCGRDRNNKYVFCGWRNLICGRLVCTYPTRKPFHQENGDVIYAFVRDSVCITVDYKLPRTVPDPLAVKNGSQCDIG
RVCVNRECVESRIIKASAHVCSQQCSGHGVCDSRNKCHCSPGYKPPNCQIRSKGFSIFPEEDMGSIMERASGKTENTWLLGFLIALPILI
VTTAIVLARKQLKKWFAKEEEFPSSESKSEGSTQTYASQSSSEGSTQTYASQTRSESSSQADTSKSKSEDSAEAYTSRSKSQDSTQTQSS

--------------------------------------------------------------
>74887_74887_6_RNF170-ADAM32_RNF170_chr8_42742871_ENST00000527424_ADAM32_chr8_39079129_ENST00000519315_length(transcript)=1467nt_BP=382nt
TTCGCTGCGTGTCGAGGCGAGCACGCGCTCCGCCCTGGAGGCTGCGGCGACGGGTCCTCCTCCGCCGTCCGGTCGCGCCCTCGCGGAAGC
TCGGCAGTGCGCGTGCGCCCGCACCCGCACTCCAAATTAGAAAGGGGACGTCTAGTGGGTTGCCCGGGAGGGGTGGCGGGAGCGGTCCTG
GAAATAATCTGTCCTCTGTCGCCGGGAACTGGCGAGGTAGTTCCTTCGCGGTGGAGAGACCTGGAATGGCCAAATATCAAGGTGAAGTTC
AAAGTTTGAAACTGGATGATGATTCAGTTATAGAAGGAGTAAGCGACCAAGTACTTGTGGCAGTTGTGGTCAGTTTCGCTTTGATTGCTA
CCCTGGTATATGCACTTTTCAGCAATGTGGACCTGCAAGCTGTTGTGATTTTCGAACTTGTGTACTGAAAGACGGAGCAAAATGTTATAA
AGGACTGTGCTGCAAAGACTGTCAAATTTTACAATCAGGCGTTGAATGTAGGCCGAAAGCACATCCTGAATGTGACATCGCTGAAAATTG
TAATGGAACCTCACCAGAATGTGGTCCTGACATAACTTTAATCAATGGACTTTCATGCAAAAATAATAAGTTTATTTGTTATGACGGAGA
CTGCCATGATCTCGATGCACGTTGTGAGAGTGTATTTGGAAAAGGTTCAAGAAATGCTCCATTTGCCTGCTATGAAGAAATACAATCTCA
ATCAGACAGATTTGGGAACTGTGGTAGGGATAGAAATAACAAATATGTGTTCTGTGGATGGAGGAATCTTATATGTGGAAGATTAGTTTG
TACCTACCCTACTCGAAAGCCTTTCCATCAAGAAAATGGTGATGTGATTTATGCTTTCGTACGAGATTCTGTATGCATAACTGTAGACTA
CAAATTGCCTCGAACAGTTCCAGATCCACTGGCTGTCAAAAATGGCTCTCAGTGTGATATTGGGAGGGTTTGTGTAAATCGTGAATGTGT
AGAATCAAGGATAATTAAGGCTTCAGCACATGTTTGTTCACAACAGTGTTCTGGACATGGAGTGTGTGATTCCAGAAACAAGTGCCATTG
TTCGCCAGGCTATAAGCCTCCAAACTGCCAAATACGTTCCAAAGGATTTTCCATATTTCCTGAGGAAGATATGGGTTCAATCATGGAAAG
AGCATCTGGGAAGACTGAAAACACCTGGCTTCTAGGTTTCCTCATTGCTCTTCCTATTCTCATTGTAACAACCGCAATAGTTTTGGCAAG
GAAACAGTTGAAAAAGTGGTTCGCCAAGGAAGAGGAATTCCCAAGTAGCGAATCCAAATCACAGGACAGTACCCAAACACAAAGCAGTAG
TAACTAGTGATTCCTTCAGAAGGCAACGGATAACATCGAGAGTCTCGCTAAGAAATGAAAATTCTGTCTTTCCTTCCGTGGTCACAGCTG

>74887_74887_6_RNF170-ADAM32_RNF170_chr8_42742871_ENST00000527424_ADAM32_chr8_39079129_ENST00000519315_length(amino acids)=310AA_BP=
MKDGAKCYKGLCCKDCQILQSGVECRPKAHPECDIAENCNGTSPECGPDITLINGLSCKNNKFICYDGDCHDLDARCESVFGKGSRNAPF
ACYEEIQSQSDRFGNCGRDRNNKYVFCGWRNLICGRLVCTYPTRKPFHQENGDVIYAFVRDSVCITVDYKLPRTVPDPLAVKNGSQCDIG
RVCVNRECVESRIIKASAHVCSQQCSGHGVCDSRNKCHCSPGYKPPNCQIRSKGFSIFPEEDMGSIMERASGKTENTWLLGFLIALPILI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RNF170-ADAM32


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RNF170-ADAM32


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RNF170-ADAM32


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource