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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATF7IP-VIPR2 (FusionGDB2 ID:7493)

Fusion Gene Summary for ATF7IP-VIPR2

check button Fusion gene summary
Fusion gene informationFusion gene name: ATF7IP-VIPR2
Fusion gene ID: 7493
HgeneTgene
Gene symbol

ATF7IP

VIPR2

Gene ID

55729

7434

Gene nameactivating transcription factor 7 interacting proteinvasoactive intestinal peptide receptor 2
SynonymsAM|ATF-IP|MCAF|MCAF1|p621C16DUPq36.3|DUP7q36.3|PACAP-R-3|PACAP-R3|VIP-R-2|VPAC2|VPAC2R|VPCAP2R
Cytomap

12p13.1

7q36.3

Type of geneprotein-codingprotein-coding
Descriptionactivating transcription factor 7-interacting protein 1ATF-interacting proteinATF7-interacting proteinATFa-associated modulatorMBD1-containing chromatin-associated factor 1vasoactive intestinal polypeptide receptor 2PACAP type III receptorVIP and PACAP receptor 2helodermin-preferring VIP receptorpituitary adenylate cyclase-activating polypeptide type III receptor
Modification date2020031320200313
UniProtAcc

Q6VMQ6

.
Ensembl transtripts involved in fusion geneENST00000261168, ENST00000536444, 
ENST00000540793, ENST00000543189, 
ENST00000544627, ENST00000541654, 
ENST00000421760, ENST00000262178, 
ENST00000377633, ENST00000402066, 
Fusion gene scores* DoF score16 X 15 X 8=19205 X 5 X 5=125
# samples 207
** MAII scorelog2(20/1920*10)=-3.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/125*10)=-0.836501267717121
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATF7IP [Title/Abstract] AND VIPR2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATF7IP(14634119)-VIPR2(158824560), # samples:3
Anticipated loss of major functional domain due to fusion event.ATF7IP-VIPR2 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
ATF7IP-VIPR2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ATF7IP-VIPR2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATF7IP

GO:0006306

DNA methylation

12665582

HgeneATF7IP

GO:0045892

negative regulation of transcription, DNA-templated

12665582

HgeneATF7IP

GO:0045893

positive regulation of transcription, DNA-templated

12665582

HgeneATF7IP

GO:0045898

regulation of RNA polymerase II transcriptional preinitiation complex assembly

12665582


check buttonFusion gene breakpoints across ATF7IP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across VIPR2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-A4QI-01AATF7IPchr12

14634119

-VIPR2chr7

158824560

-
ChimerDB4STADTCGA-BR-A4QI-01AATF7IPchr12

14634119

+VIPR2chr7

158824560

-
ChimerDB4STADTCGA-BR-A4QI-01AATF7IPchr12

14634119

+VIPR2chr7

158824758

-
ChimerDB4STADTCGA-BR-A4QIATF7IPchr12

14634119

+VIPR2chr7

158824560

-
ChimerDB4STADTCGA-BR-A4QIATF7IPchr12

14634119

+VIPR2chr7

158824758

-


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Fusion Gene ORF analysis for ATF7IP-VIPR2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000261168ENST00000421760ATF7IPchr12

14634119

+VIPR2chr7

158824560

-
5CDS-intronENST00000261168ENST00000421760ATF7IPchr12

14634119

+VIPR2chr7

158824758

-
5CDS-intronENST00000536444ENST00000421760ATF7IPchr12

14634119

+VIPR2chr7

158824560

-
5CDS-intronENST00000536444ENST00000421760ATF7IPchr12

14634119

+VIPR2chr7

158824758

-
5CDS-intronENST00000540793ENST00000421760ATF7IPchr12

14634119

+VIPR2chr7

158824560

-
5CDS-intronENST00000540793ENST00000421760ATF7IPchr12

14634119

+VIPR2chr7

158824758

-
5CDS-intronENST00000543189ENST00000421760ATF7IPchr12

14634119

+VIPR2chr7

158824560

-
5CDS-intronENST00000543189ENST00000421760ATF7IPchr12

14634119

+VIPR2chr7

158824758

-
5CDS-intronENST00000544627ENST00000421760ATF7IPchr12

14634119

+VIPR2chr7

158824560

-
5CDS-intronENST00000544627ENST00000421760ATF7IPchr12

14634119

+VIPR2chr7

158824758

-
Frame-shiftENST00000261168ENST00000262178ATF7IPchr12

14634119

+VIPR2chr7

158824560

-
Frame-shiftENST00000261168ENST00000262178ATF7IPchr12

14634119

+VIPR2chr7

158824758

-
Frame-shiftENST00000261168ENST00000377633ATF7IPchr12

14634119

+VIPR2chr7

158824560

-
Frame-shiftENST00000261168ENST00000377633ATF7IPchr12

14634119

+VIPR2chr7

158824758

-
Frame-shiftENST00000261168ENST00000402066ATF7IPchr12

14634119

+VIPR2chr7

158824560

-
Frame-shiftENST00000261168ENST00000402066ATF7IPchr12

14634119

+VIPR2chr7

158824758

-
Frame-shiftENST00000536444ENST00000262178ATF7IPchr12

14634119

+VIPR2chr7

158824560

-
Frame-shiftENST00000536444ENST00000262178ATF7IPchr12

14634119

+VIPR2chr7

158824758

-
Frame-shiftENST00000536444ENST00000377633ATF7IPchr12

14634119

+VIPR2chr7

158824560

-
Frame-shiftENST00000536444ENST00000377633ATF7IPchr12

14634119

+VIPR2chr7

158824758

-
Frame-shiftENST00000536444ENST00000402066ATF7IPchr12

14634119

+VIPR2chr7

158824560

-
Frame-shiftENST00000536444ENST00000402066ATF7IPchr12

14634119

+VIPR2chr7

158824758

-
Frame-shiftENST00000540793ENST00000262178ATF7IPchr12

14634119

+VIPR2chr7

158824560

-
Frame-shiftENST00000540793ENST00000262178ATF7IPchr12

14634119

+VIPR2chr7

158824758

-
Frame-shiftENST00000540793ENST00000377633ATF7IPchr12

14634119

+VIPR2chr7

158824560

-
Frame-shiftENST00000540793ENST00000377633ATF7IPchr12

14634119

+VIPR2chr7

158824758

-
Frame-shiftENST00000540793ENST00000402066ATF7IPchr12

14634119

+VIPR2chr7

158824560

-
Frame-shiftENST00000540793ENST00000402066ATF7IPchr12

14634119

+VIPR2chr7

158824758

-
Frame-shiftENST00000543189ENST00000262178ATF7IPchr12

14634119

+VIPR2chr7

158824758

-
Frame-shiftENST00000543189ENST00000377633ATF7IPchr12

14634119

+VIPR2chr7

158824758

-
Frame-shiftENST00000543189ENST00000402066ATF7IPchr12

14634119

+VIPR2chr7

158824758

-
Frame-shiftENST00000544627ENST00000262178ATF7IPchr12

14634119

+VIPR2chr7

158824560

-
Frame-shiftENST00000544627ENST00000262178ATF7IPchr12

14634119

+VIPR2chr7

158824758

-
Frame-shiftENST00000544627ENST00000377633ATF7IPchr12

14634119

+VIPR2chr7

158824560

-
Frame-shiftENST00000544627ENST00000377633ATF7IPchr12

14634119

+VIPR2chr7

158824758

-
Frame-shiftENST00000544627ENST00000402066ATF7IPchr12

14634119

+VIPR2chr7

158824560

-
Frame-shiftENST00000544627ENST00000402066ATF7IPchr12

14634119

+VIPR2chr7

158824758

-
In-frameENST00000543189ENST00000262178ATF7IPchr12

14634119

+VIPR2chr7

158824560

-
In-frameENST00000543189ENST00000377633ATF7IPchr12

14634119

+VIPR2chr7

158824560

-
In-frameENST00000543189ENST00000402066ATF7IPchr12

14634119

+VIPR2chr7

158824560

-
intron-3CDSENST00000541654ENST00000262178ATF7IPchr12

14634119

+VIPR2chr7

158824560

-
intron-3CDSENST00000541654ENST00000262178ATF7IPchr12

14634119

+VIPR2chr7

158824758

-
intron-3CDSENST00000541654ENST00000377633ATF7IPchr12

14634119

+VIPR2chr7

158824560

-
intron-3CDSENST00000541654ENST00000377633ATF7IPchr12

14634119

+VIPR2chr7

158824758

-
intron-3CDSENST00000541654ENST00000402066ATF7IPchr12

14634119

+VIPR2chr7

158824560

-
intron-3CDSENST00000541654ENST00000402066ATF7IPchr12

14634119

+VIPR2chr7

158824758

-
intron-intronENST00000541654ENST00000421760ATF7IPchr12

14634119

+VIPR2chr7

158824560

-
intron-intronENST00000541654ENST00000421760ATF7IPchr12

14634119

+VIPR2chr7

158824758

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000543189ATF7IPchr1214634119+ENST00000262178VIPR2chr7158824560-6798414114232761044
ENST00000543189ATF7IPchr1214634119+ENST00000377633VIPR2chr7158824560-4518414114232761044
ENST00000543189ATF7IPchr1214634119+ENST00000402066VIPR2chr7158824560-4455414114232761044

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000543189ENST00000262178ATF7IPchr1214634119+VIPR2chr7158824560-0.0001816250.9998184
ENST00000543189ENST00000377633ATF7IPchr1214634119+VIPR2chr7158824560-0.0002160620.99978393
ENST00000543189ENST00000402066ATF7IPchr1214634119+VIPR2chr7158824560-0.0002235130.99977654

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Fusion Genomic Features for ATF7IP-VIPR2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ATF7IP-VIPR2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:14634119/chr7:158824560)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATF7IP

Q6VMQ6

.
FUNCTION: Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (PubMed:27732843). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 (PubMed:12665582). Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:14536086, PubMed:27732843). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (PubMed:19106100). {ECO:0000269|PubMed:12665582, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:19106100, ECO:0000269|PubMed:27732843}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATF7IPchr12:14634119chr7:158824560ENST00000261168+1315617_66510931271.0Coiled coilOntology_term=ECO:0000255
HgeneATF7IPchr12:14634119chr7:158824560ENST00000540793+1214617_66510931271.0Coiled coilOntology_term=ECO:0000255
HgeneATF7IPchr12:14634119chr7:158824560ENST00000261168+1315349_58010931271.0Compositional biasNote=Glu-rich
HgeneATF7IPchr12:14634119chr7:158824560ENST00000540793+1214349_58010931271.0Compositional biasNote=Glu-rich
HgeneATF7IPchr12:14634119chr7:158824560ENST00000261168+1315553_57110931271.0MotifNuclear localization signal
HgeneATF7IPchr12:14634119chr7:158824560ENST00000540793+1214553_57110931271.0MotifNuclear localization signal
TgeneVIPR2chr12:14634119chr7:158824560ENST000002621781013381_438367439.0Topological domainCytoplasmic

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATF7IPchr12:14634119chr7:158824560ENST00000543189+113617_66501106.0Coiled coilOntology_term=ECO:0000255
HgeneATF7IPchr12:14634119chr7:158824560ENST00000543189+113349_58001106.0Compositional biasNote=Glu-rich
HgeneATF7IPchr12:14634119chr7:158824560ENST00000261168+13151160_127010931271.0DomainFibronectin type-III
HgeneATF7IPchr12:14634119chr7:158824560ENST00000540793+12141160_127010931271.0DomainFibronectin type-III
HgeneATF7IPchr12:14634119chr7:158824560ENST00000543189+1131160_127001106.0DomainFibronectin type-III
HgeneATF7IPchr12:14634119chr7:158824560ENST00000543189+113553_57101106.0MotifNuclear localization signal
TgeneVIPR2chr12:14634119chr7:158824560ENST000002621781013152_158367439.0Topological domainCytoplasmic
TgeneVIPR2chr12:14634119chr7:158824560ENST000002621781013179_203367439.0Topological domainExtracellular
TgeneVIPR2chr12:14634119chr7:158824560ENST000002621781013228_240367439.0Topological domainCytoplasmic
TgeneVIPR2chr12:14634119chr7:158824560ENST00000262178101324_126367439.0Topological domainExtracellular
TgeneVIPR2chr12:14634119chr7:158824560ENST000002621781013263_279367439.0Topological domainExtracellular
TgeneVIPR2chr12:14634119chr7:158824560ENST000002621781013304_328367439.0Topological domainCytoplasmic
TgeneVIPR2chr12:14634119chr7:158824560ENST000002621781013349_360367439.0Topological domainExtracellular
TgeneVIPR2chr12:14634119chr7:158824560ENST000002621781013127_151367439.0TransmembraneHelical%3B Name%3D1
TgeneVIPR2chr12:14634119chr7:158824560ENST000002621781013159_178367439.0TransmembraneHelical%3B Name%3D2
TgeneVIPR2chr12:14634119chr7:158824560ENST000002621781013204_227367439.0TransmembraneHelical%3B Name%3D3
TgeneVIPR2chr12:14634119chr7:158824560ENST000002621781013241_262367439.0TransmembraneHelical%3B Name%3D4
TgeneVIPR2chr12:14634119chr7:158824560ENST000002621781013280_303367439.0TransmembraneHelical%3B Name%3D5
TgeneVIPR2chr12:14634119chr7:158824560ENST000002621781013329_348367439.0TransmembraneHelical%3B Name%3D6
TgeneVIPR2chr12:14634119chr7:158824560ENST000002621781013361_380367439.0TransmembraneHelical%3B Name%3D7


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Fusion Gene Sequence for ATF7IP-VIPR2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>7493_7493_1_ATF7IP-VIPR2_ATF7IP_chr12_14634119_ENST00000543189_VIPR2_chr7_158824560_ENST00000262178_length(transcript)=6798nt_BP=4141nt
GGCGGCGGCGGTGGCAGCGGCGGCGCGGCGACTGAAGCGCGCGAAAAGCTGAGGCGGCAACGTCGGGGACGGCTGCGCGGGACGGCTCTG
TAGGAAGGAACTTGGTTCCCCCTCCCTCAGCTTCCGCCCCAAAAGATTCAGAATGGACAGTTTAGAAGAACCTCAGAAAAAAGTCTTTAA
GGCTCGAAAAACGATGAGAGTGAGTGATCGTCAGCAACTTGAAGCAGTGTACAAGGTCAAAGAAGAACTGTTGAAAACTGATGTCAAGCT
GTTAAATGGCAACCATGAAAATGGAGATTTGGACCCAACCTCACCTTTGGAAAACATGGATTACATTAAAGACAAGGAAGAGGTGAATGG
CATTGAAGAGATTTGTTTTGATCCTGAAGGAAGTAAAGCAGAATGGAAGGAAACACCCTGTATCCTAAGTGTTAATGTAAAAAACAAGCA
GGATGATGATTTAAATTGTGAACCTTTGTCTCCCCATAATATAACTCCAGAACCAGTCTCTAAACTGCCTGCTGAACCAGTTTCTGGTGA
TCCAGCCCCTGGTGATCTGGATGCCGGAGATCCAGCCTCCGGAGTACTGGCCTCTGGTGATTCCACCTCTGGTGATCCCACCTCTAGCGA
GCCCTCCTCTAGTGATGCTGCCTCTGGTGATGCAACCTCTGGTGATGCCCCTTCTGGTGATGTGTCCCCTGGTGATGCCACCTCTGGTGA
TGCCACTGCTGATGATCTCTCCTCTGGTGATCCCACCTCTAGTGATCCCATCCCAGGTGAACCGGTCCCTGTTGAACCCATTTCTGGTGA
TTGTGCCGCTGATGATATAGCCTCTAGTGAAATAACTTCTGTTGATCTGGCTTCTGGAGCACCAGCTTCCACTGATCCAGCCTCTGATGA
TCTGGCCTCTGGTGATCTATCCTCTAGTGAACTGGCCTCTGATGATCTGGCCACTGGTGAACTGGCCTCTGATGAGCTGACTTCTGAATC
AACCTTTGATCGTACCTTTGAACCAAAGTCTGTACCAGTTTGTGAACCAGTTCCTGAAATTGACAATATAGAACCAAGTAGCAATAAAGA
TGATGATTTTCTTGAAAAAAATGGAGCTGATGAAAAATTAGAGCAAATTCAGAGTAAAGACTCATTGGATGAGAAAAATAAAGCTGATAA
TAATATTGATGCTAATGAAGAAACTCTAGAAACAGATGATACAACTATTTGTTCAGATCGACCTCCTGAAAATGAAAAGAAGGTAGAGGA
AGATATTATCACAGAGCTTGCTCTTGGAGAAGATGCTATATCTAGCAGTATGGAAATTGACCAAGGTGAAAAGAATGAAGATGAAACTTC
TGCAGATCTTGTAGAAACGATTAATGAAAATGTTATTGAAGATAACAAAAGTGAGAATATCTTAGAAAATACAGACTCTATGGAGACAGA
TGAAATCATTCCTATTTTGGAAAAGCTTGCACCTTCTGAGGATGAACTTACTTGCTTTTCTAAAACATCTCTCCTTCCAATCGATGAGAC
AAATCCAGATTTGGAAGAGAAAATGGAAAGTTCTTTTGGTTCACCATCTAAACAAGAAAGTAGTGAGAGTTTGCCAAAAGAAGCCTTTCT
GGTCCTCTCTGATGAAGAGGATATTTCGGGTGAAAAAGATGAGTCTGAAGTTATATCGCAAAATGAAACGTGCTCTCCAGAAGTAGAAAG
TAATGAAAAGGACAACAAACCTGAGGAAGAAGAGCAAGTAATACATGAAGATGATGAAAGACCTTCTGAGAAAAATGAATTTTCTAGACG
AAAACGTTCTAAATCAGAAGACATGGACAATGTACAGTCTAAACGTCGTCGATATATGGAAGAAGAATATGAGGCAGAATTTCAAGTAAA
GATTACAGCCAAAGGAGACATTAACCAGAAACTTCAAAAGGTTATACAGTGGTTGCTGGAAGAAAAATTGTGTGCGCTGCAGTGTGCTGT
ATTTGATAAGACTTTGGCAGAATTGAAAACACGAGTGGAAAAGATTGAATGTAACAAGAGGCATAAAACAGTTCTCACTGAACTACAGGC
CAAGATAGCCAGGTTAACCAAACGCTTTGAAGCAGCCAAAGAAGATCTTAAGAAAAGACATGAACATCCACCCAACCCACCAGTATCACC
AGGAAAAACTGTAAATGATGTCAACAGCAATAATAACATGTCTTACAGAAATGCAGGCACAGTGAGACAGATGCTGGAGTCCAAAAGAAA
TGTAAGCGAGAGTGCACCACCATCCTTTCAAACTCCTGTGAATACAGTATCTTCAACCAATCTTGTCACTCCTCCAGCAGTTGTCAGTAG
TCAACCTAAATTGCAGACTCCAGTGACTTCGGGTTCCCTCACAGCAACGTCAGTTCTTCCTGCACCCAATACAGCTACTGTAGTTGCTAC
TACTCAGGTGCCTAGTGGAAATCCCCAGCCTACAATCTCTTTACAGCCTTTGCCAGTGATTTTGCATGTACCTGTTGCAGTATCCTCCCA
GCCTCAGCTTCTACAGAGCCATCCAGGGACTTTGGTGACTAATCAACCATCTGGCAATGTTGAATTCATTTCTGTGCAAAGCCCACCTAC
AGTGAGTGGTCTTACCAAAAATCCAGTATCCTTGCCATCCTTGCCAAATCCCACTAAACCAAACAACGTTCCTTCTGTGCCCAGTCCTAG
TATTCAAAGGAACCCTACTGCCAGTGCTGCACCATTGGGAACAACACTTGCTGTGCAGGCTGTTCCAACAGCACACTCTATTGTACAAGC
CACAAGGACTTCTTTACCCACAGTGGGCCCATCAGGACTCTATAGTCCATCAACTAATCGAGGTCCTATACAGATGAAAATTCCAATTTC
TGCATTTAGTACTTCGTCTGCTGCAGAACAGAACAGCAATACCACCCCAAGAATTGAAAACCAGACAAACAAAACAATAGATGCTTCTGT
CAGTAAGAAAGCAGCTGATAGCACATCACAGTGTGGAAAAGCCACTGGCAGTGATTCAAGTGGTGTCATTGATCTCACAATGGATGATGA
AGAGAGTGGAGCTTCACAAGACCCCAAAAAACTAAATCACACTCCTGTATCAACCATGAGTTCTTCTCAGCCTGTGTCACGACCATTGCA
ACCCATACAACCAGCACCGCCTCTTCAACCATCTGGGGTGCCAACAAGTGGACCATCTCAGACCACCATACACTTACTACCTACAGGTAA
GAGATTTTTCTTGTATATGGCCCCAAGATACATGTAGTTCTCTTCAGCATTTAGTTGGAATGGCATATAATAATGTTAAATTTTGCAAAA
ATTTCTTATAATGTCATATTAAAAGTATTGTTATAAGTTCAAGAGATCTGTACTACAACATAGAAACTATAGTATAGTTAAAATCAATGT
AGTATATTCTTGAAAATAGCTGATAGAGCAGATTTTAAGTATTGTCACCACACACAAAAAAGGTAAGTATGTGAGATCATGCATATGTCA
GCTAGATTTAGCCATTCTGCAGTGTATGCATATTTCAAACATGTTGTATACCATAAATATATATAATTTTTGTCAATTAAAAAATAGTTT
TCAAAAAAGAAATGGCAGTATAACCAAAACTAATCTATTATTATTTTTCTTCCCTTAGGAGAGTTAAACAGAGAAAATTGTTGATGTATA
CTAGTTGATTTGTGCTCTGAGTGTTGTCTTTAATTTAACTTTATTTATGGCCTGTATTAGTATAGTACACAATTTGATATTGGTATATTC
TCTACTCTATTAAGAAACACCTTACCTAGTTAGAGTGGGAATGGTCAATTGTGATTTACCCCAGATGATGGAAATCATGGTAAAGGATAG
CCTTCAATGAGAGTCTTAAAGATATGGAAAGTGGCTGAGAAAAGAAGGGAAAATGTTAAAGAAAGCTTGTAGTTTCTTGTATATATCATA
TATTAGTTACATACATATGTTACATGCATGTTACATATGTAGATGACATTTTAAAATTATATATTAACCACATGTATATAAGCAGTAGTA
GAATATATCACATAAACACAAGCTTATATAAAAGGTATATTTAAACTTTAAAGTAAAGAAAAATAATAAAATGAACTACGTATGAACTCT
TGGCCTGGTGGTGGCCGTCCTCTACTGTTTCCTGAACAGTGAGGTGCAGTGCGAGCTGAAGCGAAAATGGCGAAGCCGGTGCCCGACCCC
GTCCGCGAGCCGGGATTACAGGGTCTGCGGTTCCTCCTTCTCCCGCAACGGCTCGGAGGGCGCCCTGCAGTTCCACCGCGGCTCCCGCGC
CCAGTCCTTCCTGCAAACGGAGACCTCGGTCATCTAGCCCCACCCCTGCCTGTCGGACGCGGCGGGAGGCCCACGGTTCGGGGCTTCTGC
GGGGCTGAGACGCCGGCTTCCTCCTTCCAGATGCCCGAGCACCGTGTCGGGCAGGTCAGCGCGGTCCTGACTCCGTCAAGCTGGTTGTCC
ACTAAACCCCATACCTGGAATTGGAGTCGTGTTGTCATTGACTCGATTTAAACTCCAGCATTTAGATAATCTTGTGCAAAATGTGTTTCA
GCCGTATAGTGGATCCACTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTGGACTGCAGTGGCCTGATCT
CTGCTCCCTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCATAGCTGGGACTACAGGCGCCCGCCAACACGCC
TGGCTAATTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATGGGCCCGCCT
CGGCCTCCCAAAGTGCTGGGATTAAGGCGTGAGCCACTGCGCCCGGCCCAAGAGAATAGGGGAGCCAAGGAGGAAATGTGGAAACGCAGT
TGTGTGGCCCAGCACGAGCCTGGGCGACCACCGGGTGACATCCGTCCCACATCAGGGCGGCCTCCCAGGTCCCATAAGGGTAGCCCCCTC
ATCTGCAGGACAGAGGGAAGCCAGTCAGGGCCCCCCTGACGTTAGGACCAGGAGAAATCAACAGGAGGGCAGCCCGTCCTCTCTCTTGGG
GCGCCCACCCGGCCCGGCTGAGCCCTGCCCCACCCAACTCCACAGGGCTGTTTTGCCTCCCCACGGAAGGCGGGCTGAGGAGACAACCAG
ATCAGGAGAGCAAGGTCATGAAGGAGGGGACCTCTCCACACAGGTGTTCCGTGGGACCCTCAGCAGCTCTGGCTCTGCCTCAGGAGGTCA
CCTGCCGCCCTGTGGGAGCCGCAGAGCCTGACGCTCAGCCCCAGGCCAGCTGCGGCCAGGCCTGCGGGCCCCTGGTGATGGGGTTACGTG
GGGTGCGGGATACAGCTGAGTGGGAACCGGAAACCTATTCTCTTTTTAACAAAAATAATCTTAGGATAAGAATTATTTTAACAACATATA
AAACTGTTTCAAGCCCTCCTCCCCAGAGCTGGCGCTCAGCAGCCCTAGCGGCTGCTCCTTCAGGCGAAGGGTGGTTTGCAGATGTGGGGA
GGGTGTCTGGGGACGTTGCTGAGCCAGCTGCAGAAGGGTGGGGATATCAGGGCACAGTCTCCATGTGTGTGCCAAGCCCTGGCCCCCACA
GCGCTCGATGGACCTCAGCAAGCTGCCCAGCCCTGGCCCAGGTGCCCCGACTGTGGGACTCAGTTGTTCTGAGCACATTTGACTCCACTT
TTCCCTTAAAAATGAATGTCTTGTTCCTGTGCATTGGTGGCATCACAGACCCCAGCTGGGGCGCGATGTCAAAGGTCGGGACAGCTGTGC
CGGGAGGCAGCCACAGGGAAGCTCACACATCCTGTCAGTGTCACCTTGGTTTGCAAAACCCATATCCCCGGTAAAATGAGGCCGGACAGA
GGGGCTGTTAGGACAGCAAAGCAGCAGTGTCCAGAGACCCCTCAATCCCCAAAGGTCCGCACCCTGTCCTGCACACCCTGGGCCACGCCG
GCCACACCCCTCTGCTGCAACAAGCTCATCCCTGGACTTCTGGGAGAATGAACCCGAGGTTGGTTTGGGGAGACAGGTGAGGCGGTCGGA
TCTACAGAACAACCCACCATTTCTGGGGGCCGCAGAGGATCCATCACAGACGGATACTGGGGAGTAAACGGCCCAGGCCAGGTGCCCAGG
AAAGGACGGCTGAGCATGTGGAGCGAGAGGGAGGCAGGTGGACGCTGCAGACCCCAGGTTCAGTGCGGCCCCTCGGCTGTTCCTCCCCTG
TAGGGTTTGGACAGACCCACCCCCAGCCTTGCCCAGCTTTCAAAGGACAAAAGGGAGCATCCCCCACCTACTCTCAGGTTTTTGAGGAAA
CAAAGATTTGTGGTAACTGAAGGTGTTGGGTCAGTGGCCAGGTGCCGACACTGAGCTGTGACCCAGAGGGGACGCTGAGGAAGTGGGCGT
GAGTGGACGTGTCAGGTGGTTACCAGGCACTGGTTGTTGATGGTCGGTGGTTGGGTGTGGGCAGTCATCAGTCATCAGGTGTGCTCAGGG
GACAATCTCCCCTCAACCGCACATGTGCCACTGTTCAGCGGAGCTGACTGGTTTCTCCTGGTAGAGGGGCCGGCTGTTTCCTGACAGATG
CCTGGTGAGCAGGGGAAGCAGGACCCAGTGGTCAGCAGGTGTCTTTAACTGTCATTGTGTGTGGAATGTCGCAGACTCCTCCACGTGGCG

>7493_7493_1_ATF7IP-VIPR2_ATF7IP_chr12_14634119_ENST00000543189_VIPR2_chr7_158824560_ENST00000262178_length(amino acids)=1044AA_BP=
MDSLEEPQKKVFKARKTMRVSDRQQLEAVYKVKEELLKTDVKLLNGNHENGDLDPTSPLENMDYIKDKEEVNGIEEICFDPEGSKAEWKE
TPCILSVNVKNKQDDDLNCEPLSPHNITPEPVSKLPAEPVSGDPAPGDLDAGDPASGVLASGDSTSGDPTSSEPSSSDAASGDATSGDAP
SGDVSPGDATSGDATADDLSSGDPTSSDPIPGEPVPVEPISGDCAADDIASSEITSVDLASGAPASTDPASDDLASGDLSSSELASDDLA
TGELASDELTSESTFDRTFEPKSVPVCEPVPEIDNIEPSSNKDDDFLEKNGADEKLEQIQSKDSLDEKNKADNNIDANEETLETDDTTIC
SDRPPENEKKVEEDIITELALGEDAISSSMEIDQGEKNEDETSADLVETINENVIEDNKSENILENTDSMETDEIIPILEKLAPSEDELT
CFSKTSLLPIDETNPDLEEKMESSFGSPSKQESSESLPKEAFLVLSDEEDISGEKDESEVISQNETCSPEVESNEKDNKPEEEEQVIHED
DERPSEKNEFSRRKRSKSEDMDNVQSKRRRYMEEEYEAEFQVKITAKGDINQKLQKVIQWLLEEKLCALQCAVFDKTLAELKTRVEKIEC
NKRHKTVLTELQAKIARLTKRFEAAKEDLKKRHEHPPNPPVSPGKTVNDVNSNNNMSYRNAGTVRQMLESKRNVSESAPPSFQTPVNTVS
STNLVTPPAVVSSQPKLQTPVTSGSLTATSVLPAPNTATVVATTQVPSGNPQPTISLQPLPVILHVPVAVSSQPQLLQSHPGTLVTNQPS
GNVEFISVQSPPTVSGLTKNPVSLPSLPNPTKPNNVPSVPSPSIQRNPTASAAPLGTTLAVQAVPTAHSIVQATRTSLPTVGPSGLYSPS
TNRGPIQMKIPISAFSTSSAAEQNSNTTPRIENQTNKTIDASVSKKAADSTSQCGKATGSDSSGVIDLTMDDEESGASQDPKKLNHTPVS

--------------------------------------------------------------
>7493_7493_2_ATF7IP-VIPR2_ATF7IP_chr12_14634119_ENST00000543189_VIPR2_chr7_158824560_ENST00000377633_length(transcript)=4518nt_BP=4141nt
GGCGGCGGCGGTGGCAGCGGCGGCGCGGCGACTGAAGCGCGCGAAAAGCTGAGGCGGCAACGTCGGGGACGGCTGCGCGGGACGGCTCTG
TAGGAAGGAACTTGGTTCCCCCTCCCTCAGCTTCCGCCCCAAAAGATTCAGAATGGACAGTTTAGAAGAACCTCAGAAAAAAGTCTTTAA
GGCTCGAAAAACGATGAGAGTGAGTGATCGTCAGCAACTTGAAGCAGTGTACAAGGTCAAAGAAGAACTGTTGAAAACTGATGTCAAGCT
GTTAAATGGCAACCATGAAAATGGAGATTTGGACCCAACCTCACCTTTGGAAAACATGGATTACATTAAAGACAAGGAAGAGGTGAATGG
CATTGAAGAGATTTGTTTTGATCCTGAAGGAAGTAAAGCAGAATGGAAGGAAACACCCTGTATCCTAAGTGTTAATGTAAAAAACAAGCA
GGATGATGATTTAAATTGTGAACCTTTGTCTCCCCATAATATAACTCCAGAACCAGTCTCTAAACTGCCTGCTGAACCAGTTTCTGGTGA
TCCAGCCCCTGGTGATCTGGATGCCGGAGATCCAGCCTCCGGAGTACTGGCCTCTGGTGATTCCACCTCTGGTGATCCCACCTCTAGCGA
GCCCTCCTCTAGTGATGCTGCCTCTGGTGATGCAACCTCTGGTGATGCCCCTTCTGGTGATGTGTCCCCTGGTGATGCCACCTCTGGTGA
TGCCACTGCTGATGATCTCTCCTCTGGTGATCCCACCTCTAGTGATCCCATCCCAGGTGAACCGGTCCCTGTTGAACCCATTTCTGGTGA
TTGTGCCGCTGATGATATAGCCTCTAGTGAAATAACTTCTGTTGATCTGGCTTCTGGAGCACCAGCTTCCACTGATCCAGCCTCTGATGA
TCTGGCCTCTGGTGATCTATCCTCTAGTGAACTGGCCTCTGATGATCTGGCCACTGGTGAACTGGCCTCTGATGAGCTGACTTCTGAATC
AACCTTTGATCGTACCTTTGAACCAAAGTCTGTACCAGTTTGTGAACCAGTTCCTGAAATTGACAATATAGAACCAAGTAGCAATAAAGA
TGATGATTTTCTTGAAAAAAATGGAGCTGATGAAAAATTAGAGCAAATTCAGAGTAAAGACTCATTGGATGAGAAAAATAAAGCTGATAA
TAATATTGATGCTAATGAAGAAACTCTAGAAACAGATGATACAACTATTTGTTCAGATCGACCTCCTGAAAATGAAAAGAAGGTAGAGGA
AGATATTATCACAGAGCTTGCTCTTGGAGAAGATGCTATATCTAGCAGTATGGAAATTGACCAAGGTGAAAAGAATGAAGATGAAACTTC
TGCAGATCTTGTAGAAACGATTAATGAAAATGTTATTGAAGATAACAAAAGTGAGAATATCTTAGAAAATACAGACTCTATGGAGACAGA
TGAAATCATTCCTATTTTGGAAAAGCTTGCACCTTCTGAGGATGAACTTACTTGCTTTTCTAAAACATCTCTCCTTCCAATCGATGAGAC
AAATCCAGATTTGGAAGAGAAAATGGAAAGTTCTTTTGGTTCACCATCTAAACAAGAAAGTAGTGAGAGTTTGCCAAAAGAAGCCTTTCT
GGTCCTCTCTGATGAAGAGGATATTTCGGGTGAAAAAGATGAGTCTGAAGTTATATCGCAAAATGAAACGTGCTCTCCAGAAGTAGAAAG
TAATGAAAAGGACAACAAACCTGAGGAAGAAGAGCAAGTAATACATGAAGATGATGAAAGACCTTCTGAGAAAAATGAATTTTCTAGACG
AAAACGTTCTAAATCAGAAGACATGGACAATGTACAGTCTAAACGTCGTCGATATATGGAAGAAGAATATGAGGCAGAATTTCAAGTAAA
GATTACAGCCAAAGGAGACATTAACCAGAAACTTCAAAAGGTTATACAGTGGTTGCTGGAAGAAAAATTGTGTGCGCTGCAGTGTGCTGT
ATTTGATAAGACTTTGGCAGAATTGAAAACACGAGTGGAAAAGATTGAATGTAACAAGAGGCATAAAACAGTTCTCACTGAACTACAGGC
CAAGATAGCCAGGTTAACCAAACGCTTTGAAGCAGCCAAAGAAGATCTTAAGAAAAGACATGAACATCCACCCAACCCACCAGTATCACC
AGGAAAAACTGTAAATGATGTCAACAGCAATAATAACATGTCTTACAGAAATGCAGGCACAGTGAGACAGATGCTGGAGTCCAAAAGAAA
TGTAAGCGAGAGTGCACCACCATCCTTTCAAACTCCTGTGAATACAGTATCTTCAACCAATCTTGTCACTCCTCCAGCAGTTGTCAGTAG
TCAACCTAAATTGCAGACTCCAGTGACTTCGGGTTCCCTCACAGCAACGTCAGTTCTTCCTGCACCCAATACAGCTACTGTAGTTGCTAC
TACTCAGGTGCCTAGTGGAAATCCCCAGCCTACAATCTCTTTACAGCCTTTGCCAGTGATTTTGCATGTACCTGTTGCAGTATCCTCCCA
GCCTCAGCTTCTACAGAGCCATCCAGGGACTTTGGTGACTAATCAACCATCTGGCAATGTTGAATTCATTTCTGTGCAAAGCCCACCTAC
AGTGAGTGGTCTTACCAAAAATCCAGTATCCTTGCCATCCTTGCCAAATCCCACTAAACCAAACAACGTTCCTTCTGTGCCCAGTCCTAG
TATTCAAAGGAACCCTACTGCCAGTGCTGCACCATTGGGAACAACACTTGCTGTGCAGGCTGTTCCAACAGCACACTCTATTGTACAAGC
CACAAGGACTTCTTTACCCACAGTGGGCCCATCAGGACTCTATAGTCCATCAACTAATCGAGGTCCTATACAGATGAAAATTCCAATTTC
TGCATTTAGTACTTCGTCTGCTGCAGAACAGAACAGCAATACCACCCCAAGAATTGAAAACCAGACAAACAAAACAATAGATGCTTCTGT
CAGTAAGAAAGCAGCTGATAGCACATCACAGTGTGGAAAAGCCACTGGCAGTGATTCAAGTGGTGTCATTGATCTCACAATGGATGATGA
AGAGAGTGGAGCTTCACAAGACCCCAAAAAACTAAATCACACTCCTGTATCAACCATGAGTTCTTCTCAGCCTGTGTCACGACCATTGCA
ACCCATACAACCAGCACCGCCTCTTCAACCATCTGGGGTGCCAACAAGTGGACCATCTCAGACCACCATACACTTACTACCTACAGGTAA
GAGATTTTTCTTGTATATGGCCCCAAGATACATGTAGTTCTCTTCAGCATTTAGTTGGAATGGCATATAATAATGTTAAATTTTGCAAAA
ATTTCTTATAATGTCATATTAAAAGTATTGTTATAAGTTCAAGAGATCTGTACTACAACATAGAAACTATAGTATAGTTAAAATCAATGT
AGTATATTCTTGAAAATAGCTGATAGAGCAGATTTTAAGTATTGTCACCACACACAAAAAAGGTAAGTATGTGAGATCATGCATATGTCA
GCTAGATTTAGCCATTCTGCAGTGTATGCATATTTCAAACATGTTGTATACCATAAATATATATAATTTTTGTCAATTAAAAAATAGTTT
TCAAAAAAGAAATGGCAGTATAACCAAAACTAATCTATTATTATTTTTCTTCCCTTAGGAGAGTTAAACAGAGAAAATTGTTGATGTATA
CTAGTTGATTTGTGCTCTGAGTGTTGTCTTTAATTTAACTTTATTTATGGCCTGTATTAGTATAGTACACAATTTGATATTGGTATATTC
TCTACTCTATTAAGAAACACCTTACCTAGTTAGAGTGGGAATGGTCAATTGTGATTTACCCCAGATGATGGAAATCATGGTAAAGGATAG
CCTTCAATGAGAGTCTTAAAGATATGGAAAGTGGCTGAGAAAAGAAGGGAAAATGTTAAAGAAAGCTTGTAGTTTCTTGTATATATCATA
TATTAGTTACATACATATGTTACATGCATGTTACATATGTAGATGACATTTTAAAATTATATATTAACCACATGTATATAAGCAGTAGTA
GAATATATCACATAAACACAAGCTTATATAAAAGGTATATTTAAACTTTAAAGTAAAGAAAAATAATAAAATGAACTACGTATGAACTCT
TGGCCTGGTGGTGGCCGTCCTCTACTGTTTCCTGAACAGTGAGGTGCAGTGCGAGCTGAAGCGAAAATGGCGAAGCCGGTGCCCGACCCC
GTCCGCGAGCCGGGATTACAGGGTCTGCGGTTCCTCCTTCTCCCGCAACGGCTCGGAGGGCGCCCTGCAGTTCCACCGCGGCTCCCGCGC
CCAGTCCTTCCTGCAAACGGAGACCTCGGTCATCTAGCCCCACCCCTGCCTGTCGGACGCGGCGGGAGGCCCACGGTTCGGGGCTTCTGC
GGGGCTGAGACGCCGGCTTCCTCCTTCCAGATGCCCGAGCACCGTGTCGGGCAGGTCAGCGCGGTCCTGACTCCGTCAAGCTGGTTGTCC

>7493_7493_2_ATF7IP-VIPR2_ATF7IP_chr12_14634119_ENST00000543189_VIPR2_chr7_158824560_ENST00000377633_length(amino acids)=1044AA_BP=
MDSLEEPQKKVFKARKTMRVSDRQQLEAVYKVKEELLKTDVKLLNGNHENGDLDPTSPLENMDYIKDKEEVNGIEEICFDPEGSKAEWKE
TPCILSVNVKNKQDDDLNCEPLSPHNITPEPVSKLPAEPVSGDPAPGDLDAGDPASGVLASGDSTSGDPTSSEPSSSDAASGDATSGDAP
SGDVSPGDATSGDATADDLSSGDPTSSDPIPGEPVPVEPISGDCAADDIASSEITSVDLASGAPASTDPASDDLASGDLSSSELASDDLA
TGELASDELTSESTFDRTFEPKSVPVCEPVPEIDNIEPSSNKDDDFLEKNGADEKLEQIQSKDSLDEKNKADNNIDANEETLETDDTTIC
SDRPPENEKKVEEDIITELALGEDAISSSMEIDQGEKNEDETSADLVETINENVIEDNKSENILENTDSMETDEIIPILEKLAPSEDELT
CFSKTSLLPIDETNPDLEEKMESSFGSPSKQESSESLPKEAFLVLSDEEDISGEKDESEVISQNETCSPEVESNEKDNKPEEEEQVIHED
DERPSEKNEFSRRKRSKSEDMDNVQSKRRRYMEEEYEAEFQVKITAKGDINQKLQKVIQWLLEEKLCALQCAVFDKTLAELKTRVEKIEC
NKRHKTVLTELQAKIARLTKRFEAAKEDLKKRHEHPPNPPVSPGKTVNDVNSNNNMSYRNAGTVRQMLESKRNVSESAPPSFQTPVNTVS
STNLVTPPAVVSSQPKLQTPVTSGSLTATSVLPAPNTATVVATTQVPSGNPQPTISLQPLPVILHVPVAVSSQPQLLQSHPGTLVTNQPS
GNVEFISVQSPPTVSGLTKNPVSLPSLPNPTKPNNVPSVPSPSIQRNPTASAAPLGTTLAVQAVPTAHSIVQATRTSLPTVGPSGLYSPS
TNRGPIQMKIPISAFSTSSAAEQNSNTTPRIENQTNKTIDASVSKKAADSTSQCGKATGSDSSGVIDLTMDDEESGASQDPKKLNHTPVS

--------------------------------------------------------------
>7493_7493_3_ATF7IP-VIPR2_ATF7IP_chr12_14634119_ENST00000543189_VIPR2_chr7_158824560_ENST00000402066_length(transcript)=4455nt_BP=4141nt
GGCGGCGGCGGTGGCAGCGGCGGCGCGGCGACTGAAGCGCGCGAAAAGCTGAGGCGGCAACGTCGGGGACGGCTGCGCGGGACGGCTCTG
TAGGAAGGAACTTGGTTCCCCCTCCCTCAGCTTCCGCCCCAAAAGATTCAGAATGGACAGTTTAGAAGAACCTCAGAAAAAAGTCTTTAA
GGCTCGAAAAACGATGAGAGTGAGTGATCGTCAGCAACTTGAAGCAGTGTACAAGGTCAAAGAAGAACTGTTGAAAACTGATGTCAAGCT
GTTAAATGGCAACCATGAAAATGGAGATTTGGACCCAACCTCACCTTTGGAAAACATGGATTACATTAAAGACAAGGAAGAGGTGAATGG
CATTGAAGAGATTTGTTTTGATCCTGAAGGAAGTAAAGCAGAATGGAAGGAAACACCCTGTATCCTAAGTGTTAATGTAAAAAACAAGCA
GGATGATGATTTAAATTGTGAACCTTTGTCTCCCCATAATATAACTCCAGAACCAGTCTCTAAACTGCCTGCTGAACCAGTTTCTGGTGA
TCCAGCCCCTGGTGATCTGGATGCCGGAGATCCAGCCTCCGGAGTACTGGCCTCTGGTGATTCCACCTCTGGTGATCCCACCTCTAGCGA
GCCCTCCTCTAGTGATGCTGCCTCTGGTGATGCAACCTCTGGTGATGCCCCTTCTGGTGATGTGTCCCCTGGTGATGCCACCTCTGGTGA
TGCCACTGCTGATGATCTCTCCTCTGGTGATCCCACCTCTAGTGATCCCATCCCAGGTGAACCGGTCCCTGTTGAACCCATTTCTGGTGA
TTGTGCCGCTGATGATATAGCCTCTAGTGAAATAACTTCTGTTGATCTGGCTTCTGGAGCACCAGCTTCCACTGATCCAGCCTCTGATGA
TCTGGCCTCTGGTGATCTATCCTCTAGTGAACTGGCCTCTGATGATCTGGCCACTGGTGAACTGGCCTCTGATGAGCTGACTTCTGAATC
AACCTTTGATCGTACCTTTGAACCAAAGTCTGTACCAGTTTGTGAACCAGTTCCTGAAATTGACAATATAGAACCAAGTAGCAATAAAGA
TGATGATTTTCTTGAAAAAAATGGAGCTGATGAAAAATTAGAGCAAATTCAGAGTAAAGACTCATTGGATGAGAAAAATAAAGCTGATAA
TAATATTGATGCTAATGAAGAAACTCTAGAAACAGATGATACAACTATTTGTTCAGATCGACCTCCTGAAAATGAAAAGAAGGTAGAGGA
AGATATTATCACAGAGCTTGCTCTTGGAGAAGATGCTATATCTAGCAGTATGGAAATTGACCAAGGTGAAAAGAATGAAGATGAAACTTC
TGCAGATCTTGTAGAAACGATTAATGAAAATGTTATTGAAGATAACAAAAGTGAGAATATCTTAGAAAATACAGACTCTATGGAGACAGA
TGAAATCATTCCTATTTTGGAAAAGCTTGCACCTTCTGAGGATGAACTTACTTGCTTTTCTAAAACATCTCTCCTTCCAATCGATGAGAC
AAATCCAGATTTGGAAGAGAAAATGGAAAGTTCTTTTGGTTCACCATCTAAACAAGAAAGTAGTGAGAGTTTGCCAAAAGAAGCCTTTCT
GGTCCTCTCTGATGAAGAGGATATTTCGGGTGAAAAAGATGAGTCTGAAGTTATATCGCAAAATGAAACGTGCTCTCCAGAAGTAGAAAG
TAATGAAAAGGACAACAAACCTGAGGAAGAAGAGCAAGTAATACATGAAGATGATGAAAGACCTTCTGAGAAAAATGAATTTTCTAGACG
AAAACGTTCTAAATCAGAAGACATGGACAATGTACAGTCTAAACGTCGTCGATATATGGAAGAAGAATATGAGGCAGAATTTCAAGTAAA
GATTACAGCCAAAGGAGACATTAACCAGAAACTTCAAAAGGTTATACAGTGGTTGCTGGAAGAAAAATTGTGTGCGCTGCAGTGTGCTGT
ATTTGATAAGACTTTGGCAGAATTGAAAACACGAGTGGAAAAGATTGAATGTAACAAGAGGCATAAAACAGTTCTCACTGAACTACAGGC
CAAGATAGCCAGGTTAACCAAACGCTTTGAAGCAGCCAAAGAAGATCTTAAGAAAAGACATGAACATCCACCCAACCCACCAGTATCACC
AGGAAAAACTGTAAATGATGTCAACAGCAATAATAACATGTCTTACAGAAATGCAGGCACAGTGAGACAGATGCTGGAGTCCAAAAGAAA
TGTAAGCGAGAGTGCACCACCATCCTTTCAAACTCCTGTGAATACAGTATCTTCAACCAATCTTGTCACTCCTCCAGCAGTTGTCAGTAG
TCAACCTAAATTGCAGACTCCAGTGACTTCGGGTTCCCTCACAGCAACGTCAGTTCTTCCTGCACCCAATACAGCTACTGTAGTTGCTAC
TACTCAGGTGCCTAGTGGAAATCCCCAGCCTACAATCTCTTTACAGCCTTTGCCAGTGATTTTGCATGTACCTGTTGCAGTATCCTCCCA
GCCTCAGCTTCTACAGAGCCATCCAGGGACTTTGGTGACTAATCAACCATCTGGCAATGTTGAATTCATTTCTGTGCAAAGCCCACCTAC
AGTGAGTGGTCTTACCAAAAATCCAGTATCCTTGCCATCCTTGCCAAATCCCACTAAACCAAACAACGTTCCTTCTGTGCCCAGTCCTAG
TATTCAAAGGAACCCTACTGCCAGTGCTGCACCATTGGGAACAACACTTGCTGTGCAGGCTGTTCCAACAGCACACTCTATTGTACAAGC
CACAAGGACTTCTTTACCCACAGTGGGCCCATCAGGACTCTATAGTCCATCAACTAATCGAGGTCCTATACAGATGAAAATTCCAATTTC
TGCATTTAGTACTTCGTCTGCTGCAGAACAGAACAGCAATACCACCCCAAGAATTGAAAACCAGACAAACAAAACAATAGATGCTTCTGT
CAGTAAGAAAGCAGCTGATAGCACATCACAGTGTGGAAAAGCCACTGGCAGTGATTCAAGTGGTGTCATTGATCTCACAATGGATGATGA
AGAGAGTGGAGCTTCACAAGACCCCAAAAAACTAAATCACACTCCTGTATCAACCATGAGTTCTTCTCAGCCTGTGTCACGACCATTGCA
ACCCATACAACCAGCACCGCCTCTTCAACCATCTGGGGTGCCAACAAGTGGACCATCTCAGACCACCATACACTTACTACCTACAGGTAA
GAGATTTTTCTTGTATATGGCCCCAAGATACATGTAGTTCTCTTCAGCATTTAGTTGGAATGGCATATAATAATGTTAAATTTTGCAAAA
ATTTCTTATAATGTCATATTAAAAGTATTGTTATAAGTTCAAGAGATCTGTACTACAACATAGAAACTATAGTATAGTTAAAATCAATGT
AGTATATTCTTGAAAATAGCTGATAGAGCAGATTTTAAGTATTGTCACCACACACAAAAAAGGTAAGTATGTGAGATCATGCATATGTCA
GCTAGATTTAGCCATTCTGCAGTGTATGCATATTTCAAACATGTTGTATACCATAAATATATATAATTTTTGTCAATTAAAAAATAGTTT
TCAAAAAAGAAATGGCAGTATAACCAAAACTAATCTATTATTATTTTTCTTCCCTTAGGAGAGTTAAACAGAGAAAATTGTTGATGTATA
CTAGTTGATTTGTGCTCTGAGTGTTGTCTTTAATTTAACTTTATTTATGGCCTGTATTAGTATAGTACACAATTTGATATTGGTATATTC
TCTACTCTATTAAGAAACACCTTACCTAGTTAGAGTGGGAATGGTCAATTGTGATTTACCCCAGATGATGGAAATCATGGTAAAGGATAG
CCTTCAATGAGAGTCTTAAAGATATGGAAAGTGGCTGAGAAAAGAAGGGAAAATGTTAAAGAAAGCTTGTAGTTTCTTGTATATATCATA
TATTAGTTACATACATATGTTACATGCATGTTACATATGTAGATGACATTTTAAAATTATATATTAACCACATGTATATAAGCAGTAGTA
GAATATATCACATAAACACAAGCTTATATAAAAGGTATATTTAAACTTTAAAGTAAAGAAAAATAATAAAATGAACTACGTATGAACTCT
TGGCCTGGTGGTGGCCGTCCTCTACTGTTTCCTGAACAGTGAGGTGCAGTGCGAGCTGAAGCGAAAATGGCGAAGCCGGTGCCCGACCCC
GTCCGCGAGCCGGGATTACAGGGTCTGCGGTTCCTCCTTCTCCCGCAACGGCTCGGAGGGCGCCCTGCAGTTCCACCGCGGCTCCCGCGC
CCAGTCCTTCCTGCAAACGGAGACCTCGGTCATCTAGCCCCACCCCTGCCTGTCGGACGCGGCGGGAGGCCCACGGTTCGGGGCTTCTGC

>7493_7493_3_ATF7IP-VIPR2_ATF7IP_chr12_14634119_ENST00000543189_VIPR2_chr7_158824560_ENST00000402066_length(amino acids)=1044AA_BP=
MDSLEEPQKKVFKARKTMRVSDRQQLEAVYKVKEELLKTDVKLLNGNHENGDLDPTSPLENMDYIKDKEEVNGIEEICFDPEGSKAEWKE
TPCILSVNVKNKQDDDLNCEPLSPHNITPEPVSKLPAEPVSGDPAPGDLDAGDPASGVLASGDSTSGDPTSSEPSSSDAASGDATSGDAP
SGDVSPGDATSGDATADDLSSGDPTSSDPIPGEPVPVEPISGDCAADDIASSEITSVDLASGAPASTDPASDDLASGDLSSSELASDDLA
TGELASDELTSESTFDRTFEPKSVPVCEPVPEIDNIEPSSNKDDDFLEKNGADEKLEQIQSKDSLDEKNKADNNIDANEETLETDDTTIC
SDRPPENEKKVEEDIITELALGEDAISSSMEIDQGEKNEDETSADLVETINENVIEDNKSENILENTDSMETDEIIPILEKLAPSEDELT
CFSKTSLLPIDETNPDLEEKMESSFGSPSKQESSESLPKEAFLVLSDEEDISGEKDESEVISQNETCSPEVESNEKDNKPEEEEQVIHED
DERPSEKNEFSRRKRSKSEDMDNVQSKRRRYMEEEYEAEFQVKITAKGDINQKLQKVIQWLLEEKLCALQCAVFDKTLAELKTRVEKIEC
NKRHKTVLTELQAKIARLTKRFEAAKEDLKKRHEHPPNPPVSPGKTVNDVNSNNNMSYRNAGTVRQMLESKRNVSESAPPSFQTPVNTVS
STNLVTPPAVVSSQPKLQTPVTSGSLTATSVLPAPNTATVVATTQVPSGNPQPTISLQPLPVILHVPVAVSSQPQLLQSHPGTLVTNQPS
GNVEFISVQSPPTVSGLTKNPVSLPSLPNPTKPNNVPSVPSPSIQRNPTASAAPLGTTLAVQAVPTAHSIVQATRTSLPTVGPSGLYSPS
TNRGPIQMKIPISAFSTSSAAEQNSNTTPRIENQTNKTIDASVSKKAADSTSQCGKATGSDSSGVIDLTMDDEESGASQDPKKLNHTPVS

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Fusion Gene PPI Analysis for ATF7IP-VIPR2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneATF7IPchr12:14634119chr7:158824560ENST00000261168+1315562_8171093.33333333333331271.0SETDB1
HgeneATF7IPchr12:14634119chr7:158824560ENST00000540793+1214562_8171093.33333333333331271.0SETDB1
HgeneATF7IPchr12:14634119chr7:158824560ENST00000261168+1315965_9751093.33333333333331271.0SUMO
HgeneATF7IPchr12:14634119chr7:158824560ENST00000540793+1214965_9751093.33333333333331271.0SUMO


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneATF7IPchr12:14634119chr7:158824560ENST00000261168+13151154_12701093.33333333333331271.0MBD1
HgeneATF7IPchr12:14634119chr7:158824560ENST00000540793+12141154_12701093.33333333333331271.0MBD1
HgeneATF7IPchr12:14634119chr7:158824560ENST00000543189+1131154_127001106.0MBD1
HgeneATF7IPchr12:14634119chr7:158824560ENST00000543189+113562_81701106.0SETDB1
HgeneATF7IPchr12:14634119chr7:158824560ENST00000543189+113965_97501106.0SUMO


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATF7IP-VIPR2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATF7IP-VIPR2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource