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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATF7IP-ZIM2 (FusionGDB2 ID:7494)

Fusion Gene Summary for ATF7IP-ZIM2

check button Fusion gene summary
Fusion gene informationFusion gene name: ATF7IP-ZIM2
Fusion gene ID: 7494
HgeneTgene
Gene symbol

ATF7IP

ZIM2

Gene ID

55729

23619

Gene nameactivating transcription factor 7 interacting proteinzinc finger imprinted 2
SynonymsAM|ATF-IP|MCAF|MCAF1|p621ZNF656
Cytomap

12p13.1

19q13.43

Type of geneprotein-codingprotein-coding
Descriptionactivating transcription factor 7-interacting protein 1ATF-interacting proteinATF7-interacting proteinATFa-associated modulatorMBD1-containing chromatin-associated factor 1zinc finger imprinted 2zinc finger protein 656
Modification date2020031320200313
UniProtAcc

Q6VMQ6

.
Ensembl transtripts involved in fusion geneENST00000541654, ENST00000261168, 
ENST00000536444, ENST00000540793, 
ENST00000543189, ENST00000544627, 
ENST00000221722, ENST00000391708, 
ENST00000593711, ENST00000593931, 
ENST00000599935, ENST00000601070, 
Fusion gene scores* DoF score16 X 15 X 8=19204 X 4 X 1=16
# samples 204
** MAII scorelog2(20/1920*10)=-3.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ATF7IP [Title/Abstract] AND ZIM2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATF7IP(14577137)-ZIM2(57325038), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATF7IP

GO:0006306

DNA methylation

12665582

HgeneATF7IP

GO:0045892

negative regulation of transcription, DNA-templated

12665582

HgeneATF7IP

GO:0045893

positive regulation of transcription, DNA-templated

12665582

HgeneATF7IP

GO:0045898

regulation of RNA polymerase II transcriptional preinitiation complex assembly

12665582


check buttonFusion gene breakpoints across ATF7IP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ZIM2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ACN431174ATF7IPchr12

14577137

+ZIM2chr19

57325038

-


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Fusion Gene ORF analysis for ATF7IP-ZIM2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000541654ENST00000221722ATF7IPchr12

14577137

+ZIM2chr19

57325038

-
3UTR-intronENST00000541654ENST00000391708ATF7IPchr12

14577137

+ZIM2chr19

57325038

-
3UTR-intronENST00000541654ENST00000593711ATF7IPchr12

14577137

+ZIM2chr19

57325038

-
3UTR-intronENST00000541654ENST00000593931ATF7IPchr12

14577137

+ZIM2chr19

57325038

-
3UTR-intronENST00000541654ENST00000599935ATF7IPchr12

14577137

+ZIM2chr19

57325038

-
3UTR-intronENST00000541654ENST00000601070ATF7IPchr12

14577137

+ZIM2chr19

57325038

-
5CDS-intronENST00000261168ENST00000221722ATF7IPchr12

14577137

+ZIM2chr19

57325038

-
5CDS-intronENST00000261168ENST00000391708ATF7IPchr12

14577137

+ZIM2chr19

57325038

-
5CDS-intronENST00000261168ENST00000593711ATF7IPchr12

14577137

+ZIM2chr19

57325038

-
5CDS-intronENST00000261168ENST00000593931ATF7IPchr12

14577137

+ZIM2chr19

57325038

-
5CDS-intronENST00000261168ENST00000599935ATF7IPchr12

14577137

+ZIM2chr19

57325038

-
5CDS-intronENST00000261168ENST00000601070ATF7IPchr12

14577137

+ZIM2chr19

57325038

-
5CDS-intronENST00000536444ENST00000221722ATF7IPchr12

14577137

+ZIM2chr19

57325038

-
5CDS-intronENST00000536444ENST00000391708ATF7IPchr12

14577137

+ZIM2chr19

57325038

-
5CDS-intronENST00000536444ENST00000593711ATF7IPchr12

14577137

+ZIM2chr19

57325038

-
5CDS-intronENST00000536444ENST00000593931ATF7IPchr12

14577137

+ZIM2chr19

57325038

-
5CDS-intronENST00000536444ENST00000599935ATF7IPchr12

14577137

+ZIM2chr19

57325038

-
5CDS-intronENST00000536444ENST00000601070ATF7IPchr12

14577137

+ZIM2chr19

57325038

-
5CDS-intronENST00000540793ENST00000221722ATF7IPchr12

14577137

+ZIM2chr19

57325038

-
5CDS-intronENST00000540793ENST00000391708ATF7IPchr12

14577137

+ZIM2chr19

57325038

-
5CDS-intronENST00000540793ENST00000593711ATF7IPchr12

14577137

+ZIM2chr19

57325038

-
5CDS-intronENST00000540793ENST00000593931ATF7IPchr12

14577137

+ZIM2chr19

57325038

-
5CDS-intronENST00000540793ENST00000599935ATF7IPchr12

14577137

+ZIM2chr19

57325038

-
5CDS-intronENST00000540793ENST00000601070ATF7IPchr12

14577137

+ZIM2chr19

57325038

-
5CDS-intronENST00000543189ENST00000221722ATF7IPchr12

14577137

+ZIM2chr19

57325038

-
5CDS-intronENST00000543189ENST00000391708ATF7IPchr12

14577137

+ZIM2chr19

57325038

-
5CDS-intronENST00000543189ENST00000593711ATF7IPchr12

14577137

+ZIM2chr19

57325038

-
5CDS-intronENST00000543189ENST00000593931ATF7IPchr12

14577137

+ZIM2chr19

57325038

-
5CDS-intronENST00000543189ENST00000599935ATF7IPchr12

14577137

+ZIM2chr19

57325038

-
5CDS-intronENST00000543189ENST00000601070ATF7IPchr12

14577137

+ZIM2chr19

57325038

-
5CDS-intronENST00000544627ENST00000221722ATF7IPchr12

14577137

+ZIM2chr19

57325038

-
5CDS-intronENST00000544627ENST00000391708ATF7IPchr12

14577137

+ZIM2chr19

57325038

-
5CDS-intronENST00000544627ENST00000593711ATF7IPchr12

14577137

+ZIM2chr19

57325038

-
5CDS-intronENST00000544627ENST00000593931ATF7IPchr12

14577137

+ZIM2chr19

57325038

-
5CDS-intronENST00000544627ENST00000599935ATF7IPchr12

14577137

+ZIM2chr19

57325038

-
5CDS-intronENST00000544627ENST00000601070ATF7IPchr12

14577137

+ZIM2chr19

57325038

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ATF7IP-ZIM2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ATF7IP-ZIM2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:14577137/:57325038)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATF7IP

Q6VMQ6

.
FUNCTION: Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (PubMed:27732843). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 (PubMed:12665582). Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:14536086, PubMed:27732843). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (PubMed:19106100). {ECO:0000269|PubMed:12665582, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:19106100, ECO:0000269|PubMed:27732843}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ATF7IP-ZIM2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ATF7IP-ZIM2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATF7IP-ZIM2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATF7IP-ZIM2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource