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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RNF20-LPPR1 (FusionGDB2 ID:74954)

Fusion Gene Summary for RNF20-LPPR1

check button Fusion gene summary
Fusion gene informationFusion gene name: RNF20-LPPR1
Fusion gene ID: 74954
HgeneTgene
Gene symbol

RNF20

LPPR1

Gene ID

56254

54886

Gene namering finger protein 20phospholipid phosphatase related 1
SynonymsBRE1|BRE1A|hBRE1LPPR1|PRG-3
Cytomap

9q31.1

9q31.1

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase BRE1ABRE1 E3 ubiquitin ligase homologRING-type E3 ubiquitin transferase BRE1Ahomolog of S. cerevisiae BRE1phospholipid phosphatase-related protein type 1lipid phosphate phosphatase-related protein type 1plasticity related gene 3plasticity-related gene 3 protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000481046, ENST00000389120, 
ENST00000374874, ENST00000395056, 
ENST00000494890, 
Fusion gene scores* DoF score2 X 2 X 2=82 X 4 X 2=16
# samples 34
** MAII scorelog2(3/8*10)=1.90689059560852log2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RNF20 [Title/Abstract] AND LPPR1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRNF20(104297834)-LPPR1(104032161), # samples:1
RNF20(104297834)-LPPR1(104032162), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRNF20

GO:0000209

protein polyubiquitination

19037095

HgeneRNF20

GO:0010390

histone monoubiquitination

16307923|16337599

HgeneRNF20

GO:0030336

negative regulation of cell migration

18832071

HgeneRNF20

GO:0033523

histone H2B ubiquitination

16307923|16337599


check buttonFusion gene breakpoints across RNF20 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LPPR1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-A487-01ARNF20chr9

104297834

+LPPR1chr9

104032162

+
ChimerDB4STADTCGA-CD-A487RNF20chr9

104297834

+LPPR1chr9

104032161

+


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Fusion Gene ORF analysis for RNF20-LPPR1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000481046ENST00000374874RNF20chr9

104297834

+LPPR1chr9

104032162

+
3UTR-3CDSENST00000481046ENST00000374874RNF20chr9

104297834

+LPPR1chr9

104032161

+
3UTR-3CDSENST00000481046ENST00000395056RNF20chr9

104297834

+LPPR1chr9

104032162

+
3UTR-3CDSENST00000481046ENST00000395056RNF20chr9

104297834

+LPPR1chr9

104032161

+
3UTR-intronENST00000481046ENST00000494890RNF20chr9

104297834

+LPPR1chr9

104032162

+
3UTR-intronENST00000481046ENST00000494890RNF20chr9

104297834

+LPPR1chr9

104032161

+
5CDS-intronENST00000389120ENST00000494890RNF20chr9

104297834

+LPPR1chr9

104032162

+
5CDS-intronENST00000389120ENST00000494890RNF20chr9

104297834

+LPPR1chr9

104032161

+
In-frameENST00000389120ENST00000374874RNF20chr9

104297834

+LPPR1chr9

104032162

+
In-frameENST00000389120ENST00000374874RNF20chr9

104297834

+LPPR1chr9

104032161

+
In-frameENST00000389120ENST00000395056RNF20chr9

104297834

+LPPR1chr9

104032162

+
In-frameENST00000389120ENST00000395056RNF20chr9

104297834

+LPPR1chr9

104032161

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000389120RNF20chr9104297834+ENST00000374874LPPR1chr9104032161+2212219121133373
ENST00000389120RNF20chr9104297834+ENST00000395056LPPR1chr9104032161+2208219121133373
ENST00000389120RNF20chr9104297834+ENST00000374874LPPR1chr9104032162+2212219121133373
ENST00000389120RNF20chr9104297834+ENST00000395056LPPR1chr9104032162+2208219121133373

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000389120ENST00000374874RNF20chr9104297834+LPPR1chr9104032161+0.0006814060.9993186
ENST00000389120ENST00000395056RNF20chr9104297834+LPPR1chr9104032161+0.0006898650.99931014
ENST00000389120ENST00000374874RNF20chr9104297834+LPPR1chr9104032162+0.0006814060.9993186
ENST00000389120ENST00000395056RNF20chr9104297834+LPPR1chr9104032162+0.0006898650.99931014

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Fusion Genomic Features for RNF20-LPPR1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RNF20chr9104297834+LPPR1chr9104032161+0.0008342160.9991658
RNF20chr9104297834+LPPR1chr9104032161+0.0008342160.9991658
RNF20chr9104297834+LPPR1chr9104032161+0.0008342160.9991658
RNF20chr9104297834+LPPR1chr9104032161+0.0008342160.9991658

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for RNF20-LPPR1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:104297834/chr9:104032161)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLPPR1chr9:104297834chr9:104032161ENST0000037487418127_14721326.0TransmembraneHelical
TgeneLPPR1chr9:104297834chr9:104032161ENST0000037487418201_21821326.0TransmembraneHelical
TgeneLPPR1chr9:104297834chr9:104032161ENST0000037487418230_24721326.0TransmembraneHelical
TgeneLPPR1chr9:104297834chr9:104032161ENST0000037487418257_27721326.0TransmembraneHelical
TgeneLPPR1chr9:104297834chr9:104032161ENST000003748741867_8721326.0TransmembraneHelical
TgeneLPPR1chr9:104297834chr9:104032161ENST0000039505618127_14721326.0TransmembraneHelical
TgeneLPPR1chr9:104297834chr9:104032161ENST0000039505618201_21821326.0TransmembraneHelical
TgeneLPPR1chr9:104297834chr9:104032161ENST0000039505618230_24721326.0TransmembraneHelical
TgeneLPPR1chr9:104297834chr9:104032161ENST0000039505618257_27721326.0TransmembraneHelical
TgeneLPPR1chr9:104297834chr9:104032161ENST000003950561867_8721326.0TransmembraneHelical
TgeneLPPR1chr9:104297834chr9:104032162ENST0000037487418127_14721326.0TransmembraneHelical
TgeneLPPR1chr9:104297834chr9:104032162ENST0000037487418201_21821326.0TransmembraneHelical
TgeneLPPR1chr9:104297834chr9:104032162ENST0000037487418230_24721326.0TransmembraneHelical
TgeneLPPR1chr9:104297834chr9:104032162ENST0000037487418257_27721326.0TransmembraneHelical
TgeneLPPR1chr9:104297834chr9:104032162ENST000003748741867_8721326.0TransmembraneHelical
TgeneLPPR1chr9:104297834chr9:104032162ENST0000039505618127_14721326.0TransmembraneHelical
TgeneLPPR1chr9:104297834chr9:104032162ENST0000039505618201_21821326.0TransmembraneHelical
TgeneLPPR1chr9:104297834chr9:104032162ENST0000039505618230_24721326.0TransmembraneHelical
TgeneLPPR1chr9:104297834chr9:104032162ENST0000039505618257_27721326.0TransmembraneHelical
TgeneLPPR1chr9:104297834chr9:104032162ENST000003950561867_8721326.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRNF20chr9:104297834chr9:104032161ENST00000389120+220168_37543976.0Coiled coilOntology_term=ECO:0000255
HgeneRNF20chr9:104297834chr9:104032161ENST00000389120+220429_89843976.0Coiled coilOntology_term=ECO:0000255
HgeneRNF20chr9:104297834chr9:104032161ENST00000389120+22043_9043976.0Coiled coilOntology_term=ECO:0000255
HgeneRNF20chr9:104297834chr9:104032162ENST00000389120+220168_37543976.0Coiled coilOntology_term=ECO:0000255
HgeneRNF20chr9:104297834chr9:104032162ENST00000389120+220429_89843976.0Coiled coilOntology_term=ECO:0000255
HgeneRNF20chr9:104297834chr9:104032162ENST00000389120+22043_9043976.0Coiled coilOntology_term=ECO:0000255
HgeneRNF20chr9:104297834chr9:104032161ENST00000389120+220922_96143976.0Zinc fingerRING-type
HgeneRNF20chr9:104297834chr9:104032162ENST00000389120+220922_96143976.0Zinc fingerRING-type
TgeneLPPR1chr9:104297834chr9:104032161ENST000003748741813_3321326.0TransmembraneHelical
TgeneLPPR1chr9:104297834chr9:104032161ENST000003950561813_3321326.0TransmembraneHelical
TgeneLPPR1chr9:104297834chr9:104032162ENST000003748741813_3321326.0TransmembraneHelical
TgeneLPPR1chr9:104297834chr9:104032162ENST000003950561813_3321326.0TransmembraneHelical


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Fusion Gene Sequence for RNF20-LPPR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>74954_74954_1_RNF20-LPPR1_RNF20_chr9_104297834_ENST00000389120_LPPR1_chr9_104032161_ENST00000374874_length(transcript)=2212nt_BP=219nt
GGAAGTTCTGCCTTGTCTCCGCCGCGGGTCAGGGGTGAGAGCTGGAATCTCTGCACGGGCCTTGGAAAACGACTGTCTTCTTCTGCCAAA
ATGTCAGGAATTGGAAATAAAAGAGCAGCTGGAGAACCTGGCACCTCCATGCCTCCTGAGAAGAAGGCAGCTGTTGAAGATTCAGGGACC
ACAGTGGAAACAATTAAGCTAGGAGGTGTCTCTTCAACGCTTGTCATCATGGCTGGGACAGTGCTGCTTGCCTACTACTTCGAATGCACT
GACACTTTTCAGGTGCATATCCAAGGATTCTTCTGTCAGGACGGAGACTTAATGAAGCCTTACCCAGGGACAGAGGAAGAAAGCTTCATC
ACCCCTCTGGTGCTCTATTGTGTGCTGGCTGCCACCCCAACTGCTATTATTTTTATTGGTGAGATATCCATGTATTTCATAAAATCAACA
AGAGAATCCCTGATTGCTCAGGAGAAAACAATTCTGACCGGAGAATGCTGTTACCTGAACCCCTTACTTCGAAGGATCATAAGATTCACA
GGGGTGTTTGCATTTGGACTTTTTGCTACTGACATTTTTGTAAACGCCGGACAAGTGGTCACTGGGCACTTAACGCCATACTTCCTGACT
GTGTGCAAGCCAAACTACACCAGTGCAGACTGCCAAGCGCACCACCAGTTTATAAACAATGGGAACATTTGTACTGGGGACCTGGAAGTG
ATAGAAAAGGCTCGGAGATCCTTTCCCTCCAAACACGCTGCTCTGAGCATTTACTCCGCCTTATATGCCACGATGTATATTACAAGCACA
ATCAAGACGAAGAGCAGTCGACTGGCCAAGCCGGTGCTGTGCCTCGGAACTCTCTGCACAGCCTTCCTGACAGGCCTCAACCGGGTCTCT
GAGTATCGGAACCACTGCTCGGACGTGATTGCTGGTTTCATCCTGGGCACTGCAGTGGCCCTGTTTCTGGGAATGTGTGTGGTTCATAAC
TTTAAAGGAACGCAAGGATCTCCTTCCAAACCCAAGCCTGAGGATCCCCGTGGAGTACCCCTAATGGCTTTCCCAAGGATAGAAAGCCCT
CTGGAAACCTTAAGTGCACAGAATCACTCTGCGTCCATGACCGAAGTTACCTGAGACGACTGATGTGTCACAAGCTGTTTTTTAAAATCA
TCTTCCAATTCTATACTTCAAAACACACAGTTGCTCAATGTCAAACTGTGATGACAAATATTACGTTTATCTAGTTAGAAGCTAATGTTT
TGTACATTTTTTGTATGAGGAAGTGATGTAGCTTGCCCTGATTTTTTTTTTTTTTTTTTGGTCAGCTTTAATATATTTATGCCAGAATTT
TAAAACCAACAAAATTTTCTTGTTCAAGCGTGCATTGAAGAACCACATTTATTCAATGGTTGACGTTGTTTTGTGATATTTGTACACAAA
TTTTCTTTTCTCAGTTTTATAAACACAGAATATAACAATTCACTTTAAACTTTTATTACCACAGTTGCTGCCTCCTCCAGAATTTTTGAA
TTTTAATAAAAGGCAAACTTTTGAGCTGCAGGAAGGACAATGTTGGTTAATAATAAATCTCAAAGTCAATTGTAGAAAAAAAATTGTCTT
CAAAAAGAATGTTGCACTCTGATCTCTTAACAAATTGTTACGTTCAAAGTTTAAAGTGATATATTAACAAAGTCACCTAGTTATACAAAC
AATTGTCAGAGAATTCTGGATTTGGAGGGTATTGGGGTTATATGATTCTTTCTTAGATAATGGCCTCTACTAAATAACTCAAGATCTTTC
TGGAATGTCTTCTGGCAGGCAGGTGCCACTGTCAGCTTTTCTCCAAAAAGCAGCCAACATCAGCCTCCCCTGTCAACTCAACAGTTTTGT
ATCTCATATTATATGGACTTTATATGAAAATGAATATTTTACAGTTTGCACAGTATTATTTTACAGAAAAGGAATCAGAGAATCTACAAC
ATAGGGCCCCAGAACAACAGTTTCACTTTGTGGCTTTTAATTATTCTAGAATTTTAACTGCATCTCATTTTTCTAGCATGGTGAGAACTA
ATATGTAACTCCTTTGATTGAAGGAGCTCTTTTGTCCGTACCTATCAGAATGTTTTCTTGACACTTCCATGTTGGCTCTTCTCAGCTTTT

>74954_74954_1_RNF20-LPPR1_RNF20_chr9_104297834_ENST00000389120_LPPR1_chr9_104032161_ENST00000374874_length(amino acids)=373AA_BP=69
MSPPRVRGESWNLCTGLGKRLSSSAKMSGIGNKRAAGEPGTSMPPEKKAAVEDSGTTVETIKLGGVSSTLVIMAGTVLLAYYFECTDTFQ
VHIQGFFCQDGDLMKPYPGTEEESFITPLVLYCVLAATPTAIIFIGEISMYFIKSTRESLIAQEKTILTGECCYLNPLLRRIIRFTGVFA
FGLFATDIFVNAGQVVTGHLTPYFLTVCKPNYTSADCQAHHQFINNGNICTGDLEVIEKARRSFPSKHAALSIYSALYATMYITSTIKTK
SSRLAKPVLCLGTLCTAFLTGLNRVSEYRNHCSDVIAGFILGTAVALFLGMCVVHNFKGTQGSPSKPKPEDPRGVPLMAFPRIESPLETL

--------------------------------------------------------------
>74954_74954_2_RNF20-LPPR1_RNF20_chr9_104297834_ENST00000389120_LPPR1_chr9_104032161_ENST00000395056_length(transcript)=2208nt_BP=219nt
GGAAGTTCTGCCTTGTCTCCGCCGCGGGTCAGGGGTGAGAGCTGGAATCTCTGCACGGGCCTTGGAAAACGACTGTCTTCTTCTGCCAAA
ATGTCAGGAATTGGAAATAAAAGAGCAGCTGGAGAACCTGGCACCTCCATGCCTCCTGAGAAGAAGGCAGCTGTTGAAGATTCAGGGACC
ACAGTGGAAACAATTAAGCTAGGAGGTGTCTCTTCAACGCTTGTCATCATGGCTGGGACAGTGCTGCTTGCCTACTACTTCGAATGCACT
GACACTTTTCAGGTGCATATCCAAGGATTCTTCTGTCAGGACGGAGACTTAATGAAGCCTTACCCAGGGACAGAGGAAGAAAGCTTCATC
ACCCCTCTGGTGCTCTATTGTGTGCTGGCTGCCACCCCAACTGCTATTATTTTTATTGGTGAGATATCCATGTATTTCATAAAATCAACA
AGAGAATCCCTGATTGCTCAGGAGAAAACAATTCTGACCGGAGAATGCTGTTACCTGAACCCCTTACTTCGAAGGATCATAAGATTCACA
GGGGTGTTTGCATTTGGACTTTTTGCTACTGACATTTTTGTAAACGCCGGACAAGTGGTCACTGGGCACTTAACGCCATACTTCCTGACT
GTGTGCAAGCCAAACTACACCAGTGCAGACTGCCAAGCGCACCACCAGTTTATAAACAATGGGAACATTTGTACTGGGGACCTGGAAGTG
ATAGAAAAGGCTCGGAGATCCTTTCCCTCCAAACACGCTGCTCTGAGCATTTACTCCGCCTTATATGCCACGATGTATATTACAAGCACA
ATCAAGACGAAGAGCAGTCGACTGGCCAAGCCGGTGCTGTGCCTCGGAACTCTCTGCACAGCCTTCCTGACAGGCCTCAACCGGGTCTCT
GAGTATCGGAACCACTGCTCGGACGTGATTGCTGGTTTCATCCTGGGCACTGCAGTGGCCCTGTTTCTGGGAATGTGTGTGGTTCATAAC
TTTAAAGGAACGCAAGGATCTCCTTCCAAACCCAAGCCTGAGGATCCCCGTGGAGTACCCCTAATGGCTTTCCCAAGGATAGAAAGCCCT
CTGGAAACCTTAAGTGCACAGAATCACTCTGCGTCCATGACCGAAGTTACCTGAGACGACTGATGTGTCACAAGCTGTTTTTTAAAATCA
TCTTCCAATTCTATACTTCAAAACACACAGTTGCTCAATGTCAAACTGTGATGACAAATATTACGTTTATCTAGTTAGAAGCTAATGTTT
TGTACATTTTTTGTATGAGGAAGTGATGTAGCTTGCCCTGATTTTTTTTTTTTTTTTTTGGTCAGCTTTAATATATTTATGCCAGAATTT
TAAAACCAACAAAATTTTCTTGTTCAAGCGTGCATTGAAGAACCACATTTATTCAATGGTTGACGTTGTTTTGTGATATTTGTACACAAA
TTTTCTTTTCTCAGTTTTATAAACACAGAATATAACAATTCACTTTAAACTTTTATTACCACAGTTGCTGCCTCCTCCAGAATTTTTGAA
TTTTAATAAAAGGCAAACTTTTGAGCTGCAGGAAGGACAATGTTGGTTAATAATAAATCTCAAAGTCAATTGTAGAAAAAAAATTGTCTT
CAAAAAGAATGTTGCACTCTGATCTCTTAACAAATTGTTACGTTCAAAGTTTAAAGTGATATATTAACAAAGTCACCTAGTTATACAAAC
AATTGTCAGAGAATTCTGGATTTGGAGGGTATTGGGGTTATATGATTCTTTCTTAGATAATGGCCTCTACTAAATAACTCAAGATCTTTC
TGGAATGTCTTCTGGCAGGCAGGTGCCACTGTCAGCTTTTCTCCAAAAAGCAGCCAACATCAGCCTCCCCTGTCAACTCAACAGTTTTGT
ATCTCATATTATATGGACTTTATATGAAAATGAATATTTTACAGTTTGCACAGTATTATTTTACAGAAAAGGAATCAGAGAATCTACAAC
ATAGGGCCCCAGAACAACAGTTTCACTTTGTGGCTTTTAATTATTCTAGAATTTTAACTGCATCTCATTTTTCTAGCATGGTGAGAACTA
ATATGTAACTCCTTTGATTGAAGGAGCTCTTTTGTCCGTACCTATCAGAATGTTTTCTTGACACTTCCATGTTGGCTCTTCTCAGCTTTT

>74954_74954_2_RNF20-LPPR1_RNF20_chr9_104297834_ENST00000389120_LPPR1_chr9_104032161_ENST00000395056_length(amino acids)=373AA_BP=69
MSPPRVRGESWNLCTGLGKRLSSSAKMSGIGNKRAAGEPGTSMPPEKKAAVEDSGTTVETIKLGGVSSTLVIMAGTVLLAYYFECTDTFQ
VHIQGFFCQDGDLMKPYPGTEEESFITPLVLYCVLAATPTAIIFIGEISMYFIKSTRESLIAQEKTILTGECCYLNPLLRRIIRFTGVFA
FGLFATDIFVNAGQVVTGHLTPYFLTVCKPNYTSADCQAHHQFINNGNICTGDLEVIEKARRSFPSKHAALSIYSALYATMYITSTIKTK
SSRLAKPVLCLGTLCTAFLTGLNRVSEYRNHCSDVIAGFILGTAVALFLGMCVVHNFKGTQGSPSKPKPEDPRGVPLMAFPRIESPLETL

--------------------------------------------------------------
>74954_74954_3_RNF20-LPPR1_RNF20_chr9_104297834_ENST00000389120_LPPR1_chr9_104032162_ENST00000374874_length(transcript)=2212nt_BP=219nt
GGAAGTTCTGCCTTGTCTCCGCCGCGGGTCAGGGGTGAGAGCTGGAATCTCTGCACGGGCCTTGGAAAACGACTGTCTTCTTCTGCCAAA
ATGTCAGGAATTGGAAATAAAAGAGCAGCTGGAGAACCTGGCACCTCCATGCCTCCTGAGAAGAAGGCAGCTGTTGAAGATTCAGGGACC
ACAGTGGAAACAATTAAGCTAGGAGGTGTCTCTTCAACGCTTGTCATCATGGCTGGGACAGTGCTGCTTGCCTACTACTTCGAATGCACT
GACACTTTTCAGGTGCATATCCAAGGATTCTTCTGTCAGGACGGAGACTTAATGAAGCCTTACCCAGGGACAGAGGAAGAAAGCTTCATC
ACCCCTCTGGTGCTCTATTGTGTGCTGGCTGCCACCCCAACTGCTATTATTTTTATTGGTGAGATATCCATGTATTTCATAAAATCAACA
AGAGAATCCCTGATTGCTCAGGAGAAAACAATTCTGACCGGAGAATGCTGTTACCTGAACCCCTTACTTCGAAGGATCATAAGATTCACA
GGGGTGTTTGCATTTGGACTTTTTGCTACTGACATTTTTGTAAACGCCGGACAAGTGGTCACTGGGCACTTAACGCCATACTTCCTGACT
GTGTGCAAGCCAAACTACACCAGTGCAGACTGCCAAGCGCACCACCAGTTTATAAACAATGGGAACATTTGTACTGGGGACCTGGAAGTG
ATAGAAAAGGCTCGGAGATCCTTTCCCTCCAAACACGCTGCTCTGAGCATTTACTCCGCCTTATATGCCACGATGTATATTACAAGCACA
ATCAAGACGAAGAGCAGTCGACTGGCCAAGCCGGTGCTGTGCCTCGGAACTCTCTGCACAGCCTTCCTGACAGGCCTCAACCGGGTCTCT
GAGTATCGGAACCACTGCTCGGACGTGATTGCTGGTTTCATCCTGGGCACTGCAGTGGCCCTGTTTCTGGGAATGTGTGTGGTTCATAAC
TTTAAAGGAACGCAAGGATCTCCTTCCAAACCCAAGCCTGAGGATCCCCGTGGAGTACCCCTAATGGCTTTCCCAAGGATAGAAAGCCCT
CTGGAAACCTTAAGTGCACAGAATCACTCTGCGTCCATGACCGAAGTTACCTGAGACGACTGATGTGTCACAAGCTGTTTTTTAAAATCA
TCTTCCAATTCTATACTTCAAAACACACAGTTGCTCAATGTCAAACTGTGATGACAAATATTACGTTTATCTAGTTAGAAGCTAATGTTT
TGTACATTTTTTGTATGAGGAAGTGATGTAGCTTGCCCTGATTTTTTTTTTTTTTTTTTGGTCAGCTTTAATATATTTATGCCAGAATTT
TAAAACCAACAAAATTTTCTTGTTCAAGCGTGCATTGAAGAACCACATTTATTCAATGGTTGACGTTGTTTTGTGATATTTGTACACAAA
TTTTCTTTTCTCAGTTTTATAAACACAGAATATAACAATTCACTTTAAACTTTTATTACCACAGTTGCTGCCTCCTCCAGAATTTTTGAA
TTTTAATAAAAGGCAAACTTTTGAGCTGCAGGAAGGACAATGTTGGTTAATAATAAATCTCAAAGTCAATTGTAGAAAAAAAATTGTCTT
CAAAAAGAATGTTGCACTCTGATCTCTTAACAAATTGTTACGTTCAAAGTTTAAAGTGATATATTAACAAAGTCACCTAGTTATACAAAC
AATTGTCAGAGAATTCTGGATTTGGAGGGTATTGGGGTTATATGATTCTTTCTTAGATAATGGCCTCTACTAAATAACTCAAGATCTTTC
TGGAATGTCTTCTGGCAGGCAGGTGCCACTGTCAGCTTTTCTCCAAAAAGCAGCCAACATCAGCCTCCCCTGTCAACTCAACAGTTTTGT
ATCTCATATTATATGGACTTTATATGAAAATGAATATTTTACAGTTTGCACAGTATTATTTTACAGAAAAGGAATCAGAGAATCTACAAC
ATAGGGCCCCAGAACAACAGTTTCACTTTGTGGCTTTTAATTATTCTAGAATTTTAACTGCATCTCATTTTTCTAGCATGGTGAGAACTA
ATATGTAACTCCTTTGATTGAAGGAGCTCTTTTGTCCGTACCTATCAGAATGTTTTCTTGACACTTCCATGTTGGCTCTTCTCAGCTTTT

>74954_74954_3_RNF20-LPPR1_RNF20_chr9_104297834_ENST00000389120_LPPR1_chr9_104032162_ENST00000374874_length(amino acids)=373AA_BP=69
MSPPRVRGESWNLCTGLGKRLSSSAKMSGIGNKRAAGEPGTSMPPEKKAAVEDSGTTVETIKLGGVSSTLVIMAGTVLLAYYFECTDTFQ
VHIQGFFCQDGDLMKPYPGTEEESFITPLVLYCVLAATPTAIIFIGEISMYFIKSTRESLIAQEKTILTGECCYLNPLLRRIIRFTGVFA
FGLFATDIFVNAGQVVTGHLTPYFLTVCKPNYTSADCQAHHQFINNGNICTGDLEVIEKARRSFPSKHAALSIYSALYATMYITSTIKTK
SSRLAKPVLCLGTLCTAFLTGLNRVSEYRNHCSDVIAGFILGTAVALFLGMCVVHNFKGTQGSPSKPKPEDPRGVPLMAFPRIESPLETL

--------------------------------------------------------------
>74954_74954_4_RNF20-LPPR1_RNF20_chr9_104297834_ENST00000389120_LPPR1_chr9_104032162_ENST00000395056_length(transcript)=2208nt_BP=219nt
GGAAGTTCTGCCTTGTCTCCGCCGCGGGTCAGGGGTGAGAGCTGGAATCTCTGCACGGGCCTTGGAAAACGACTGTCTTCTTCTGCCAAA
ATGTCAGGAATTGGAAATAAAAGAGCAGCTGGAGAACCTGGCACCTCCATGCCTCCTGAGAAGAAGGCAGCTGTTGAAGATTCAGGGACC
ACAGTGGAAACAATTAAGCTAGGAGGTGTCTCTTCAACGCTTGTCATCATGGCTGGGACAGTGCTGCTTGCCTACTACTTCGAATGCACT
GACACTTTTCAGGTGCATATCCAAGGATTCTTCTGTCAGGACGGAGACTTAATGAAGCCTTACCCAGGGACAGAGGAAGAAAGCTTCATC
ACCCCTCTGGTGCTCTATTGTGTGCTGGCTGCCACCCCAACTGCTATTATTTTTATTGGTGAGATATCCATGTATTTCATAAAATCAACA
AGAGAATCCCTGATTGCTCAGGAGAAAACAATTCTGACCGGAGAATGCTGTTACCTGAACCCCTTACTTCGAAGGATCATAAGATTCACA
GGGGTGTTTGCATTTGGACTTTTTGCTACTGACATTTTTGTAAACGCCGGACAAGTGGTCACTGGGCACTTAACGCCATACTTCCTGACT
GTGTGCAAGCCAAACTACACCAGTGCAGACTGCCAAGCGCACCACCAGTTTATAAACAATGGGAACATTTGTACTGGGGACCTGGAAGTG
ATAGAAAAGGCTCGGAGATCCTTTCCCTCCAAACACGCTGCTCTGAGCATTTACTCCGCCTTATATGCCACGATGTATATTACAAGCACA
ATCAAGACGAAGAGCAGTCGACTGGCCAAGCCGGTGCTGTGCCTCGGAACTCTCTGCACAGCCTTCCTGACAGGCCTCAACCGGGTCTCT
GAGTATCGGAACCACTGCTCGGACGTGATTGCTGGTTTCATCCTGGGCACTGCAGTGGCCCTGTTTCTGGGAATGTGTGTGGTTCATAAC
TTTAAAGGAACGCAAGGATCTCCTTCCAAACCCAAGCCTGAGGATCCCCGTGGAGTACCCCTAATGGCTTTCCCAAGGATAGAAAGCCCT
CTGGAAACCTTAAGTGCACAGAATCACTCTGCGTCCATGACCGAAGTTACCTGAGACGACTGATGTGTCACAAGCTGTTTTTTAAAATCA
TCTTCCAATTCTATACTTCAAAACACACAGTTGCTCAATGTCAAACTGTGATGACAAATATTACGTTTATCTAGTTAGAAGCTAATGTTT
TGTACATTTTTTGTATGAGGAAGTGATGTAGCTTGCCCTGATTTTTTTTTTTTTTTTTTGGTCAGCTTTAATATATTTATGCCAGAATTT
TAAAACCAACAAAATTTTCTTGTTCAAGCGTGCATTGAAGAACCACATTTATTCAATGGTTGACGTTGTTTTGTGATATTTGTACACAAA
TTTTCTTTTCTCAGTTTTATAAACACAGAATATAACAATTCACTTTAAACTTTTATTACCACAGTTGCTGCCTCCTCCAGAATTTTTGAA
TTTTAATAAAAGGCAAACTTTTGAGCTGCAGGAAGGACAATGTTGGTTAATAATAAATCTCAAAGTCAATTGTAGAAAAAAAATTGTCTT
CAAAAAGAATGTTGCACTCTGATCTCTTAACAAATTGTTACGTTCAAAGTTTAAAGTGATATATTAACAAAGTCACCTAGTTATACAAAC
AATTGTCAGAGAATTCTGGATTTGGAGGGTATTGGGGTTATATGATTCTTTCTTAGATAATGGCCTCTACTAAATAACTCAAGATCTTTC
TGGAATGTCTTCTGGCAGGCAGGTGCCACTGTCAGCTTTTCTCCAAAAAGCAGCCAACATCAGCCTCCCCTGTCAACTCAACAGTTTTGT
ATCTCATATTATATGGACTTTATATGAAAATGAATATTTTACAGTTTGCACAGTATTATTTTACAGAAAAGGAATCAGAGAATCTACAAC
ATAGGGCCCCAGAACAACAGTTTCACTTTGTGGCTTTTAATTATTCTAGAATTTTAACTGCATCTCATTTTTCTAGCATGGTGAGAACTA
ATATGTAACTCCTTTGATTGAAGGAGCTCTTTTGTCCGTACCTATCAGAATGTTTTCTTGACACTTCCATGTTGGCTCTTCTCAGCTTTT

>74954_74954_4_RNF20-LPPR1_RNF20_chr9_104297834_ENST00000389120_LPPR1_chr9_104032162_ENST00000395056_length(amino acids)=373AA_BP=69
MSPPRVRGESWNLCTGLGKRLSSSAKMSGIGNKRAAGEPGTSMPPEKKAAVEDSGTTVETIKLGGVSSTLVIMAGTVLLAYYFECTDTFQ
VHIQGFFCQDGDLMKPYPGTEEESFITPLVLYCVLAATPTAIIFIGEISMYFIKSTRESLIAQEKTILTGECCYLNPLLRRIIRFTGVFA
FGLFATDIFVNAGQVVTGHLTPYFLTVCKPNYTSADCQAHHQFINNGNICTGDLEVIEKARRSFPSKHAALSIYSALYATMYITSTIKTK
SSRLAKPVLCLGTLCTAFLTGLNRVSEYRNHCSDVIAGFILGTAVALFLGMCVVHNFKGTQGSPSKPKPEDPRGVPLMAFPRIESPLETL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RNF20-LPPR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RNF20-LPPR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RNF20-LPPR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource