FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:RNF213-CEP104 (FusionGDB2 ID:74965)

Fusion Gene Summary for RNF213-CEP104

check button Fusion gene summary
Fusion gene informationFusion gene name: RNF213-CEP104
Fusion gene ID: 74965
HgeneTgene
Gene symbol

RNF213

CEP104

Gene ID

57674

9731

Gene namering finger protein 213centrosomal protein 104
SynonymsALO17|C17orf27|KIAA1618|MYMY2|MYSTR|NET57CFAP256|GlyBP|JBTS25|KIAA0562|ROC22
Cytomap

17q25.3

1p36.32

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase RNF213ALK lymphoma oligomerization partner on chromosome 17RING-type E3 ubiquitin transferase RNF213mysterincentrosomal protein of 104 kDacentrosomal protein 104kDa
Modification date2020031320200313
UniProtAcc.

O60308

Ensembl transtripts involved in fusion geneENST00000336301, ENST00000508628, 
ENST00000582970, ENST00000319921, 
ENST00000427003, ENST00000456466, 
ENST00000378223, ENST00000460038, 
ENST00000378230, 
Fusion gene scores* DoF score34 X 32 X 16=174084 X 5 X 5=100
# samples 415
** MAII scorelog2(41/17408*10)=-5.40798274174489
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RNF213 [Title/Abstract] AND CEP104 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRNF213(78337114)-CEP104(3732934), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRNF213

GO:0016567

protein ubiquitination

21799892

HgeneRNF213

GO:0051260

protein homooligomerization

24658080|26126547

HgeneRNF213

GO:0051865

protein autoubiquitination

21799892


check buttonFusion gene breakpoints across RNF213 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CEP104 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4TGCTTCGA-VF-A8AE-01ARNF213chr17

78337114

+CEP104chr1

3732934

-
ChimerDB4TGCTTCGA-VF-A8AERNF213chr17

78337114

+CEP104chr1

3732934

-


Top

Fusion Gene ORF analysis for RNF213-CEP104

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000336301ENST00000378223RNF213chr17

78337114

+CEP104chr1

3732934

-
5CDS-intronENST00000336301ENST00000460038RNF213chr17

78337114

+CEP104chr1

3732934

-
5CDS-intronENST00000508628ENST00000378223RNF213chr17

78337114

+CEP104chr1

3732934

-
5CDS-intronENST00000508628ENST00000460038RNF213chr17

78337114

+CEP104chr1

3732934

-
5CDS-intronENST00000582970ENST00000378223RNF213chr17

78337114

+CEP104chr1

3732934

-
5CDS-intronENST00000582970ENST00000460038RNF213chr17

78337114

+CEP104chr1

3732934

-
In-frameENST00000336301ENST00000378230RNF213chr17

78337114

+CEP104chr1

3732934

-
In-frameENST00000508628ENST00000378230RNF213chr17

78337114

+CEP104chr1

3732934

-
In-frameENST00000582970ENST00000378230RNF213chr17

78337114

+CEP104chr1

3732934

-
intron-3CDSENST00000319921ENST00000378230RNF213chr17

78337114

+CEP104chr1

3732934

-
intron-3CDSENST00000427003ENST00000378230RNF213chr17

78337114

+CEP104chr1

3732934

-
intron-3CDSENST00000456466ENST00000378230RNF213chr17

78337114

+CEP104chr1

3732934

-
intron-intronENST00000319921ENST00000378223RNF213chr17

78337114

+CEP104chr1

3732934

-
intron-intronENST00000319921ENST00000460038RNF213chr17

78337114

+CEP104chr1

3732934

-
intron-intronENST00000427003ENST00000378223RNF213chr17

78337114

+CEP104chr1

3732934

-
intron-intronENST00000427003ENST00000460038RNF213chr17

78337114

+CEP104chr1

3732934

-
intron-intronENST00000456466ENST00000378223RNF213chr17

78337114

+CEP104chr1

3732934

-
intron-intronENST00000456466ENST00000460038RNF213chr17

78337114

+CEP104chr1

3732934

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000508628RNF213chr1778337114+ENST00000378230CEP104chr13732934-1538811860145120663973
ENST00000582970RNF213chr1778337114+ENST00000378230CEP104chr13732934-1523911711143119173924
ENST00000336301RNF213chr1778337114+ENST00000378230CEP104chr13732934-93155787059931997

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000508628ENST00000378230RNF213chr1778337114+CEP104chr13732934-0.001554560.99844545
ENST00000582970ENST00000378230RNF213chr1778337114+CEP104chr13732934-0.0014493070.9985507
ENST00000336301ENST00000378230RNF213chr1778337114+CEP104chr13732934-0.0006774240.99932265

Top

Fusion Genomic Features for RNF213-CEP104


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for RNF213-CEP104


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:78337114/chr1:3732934)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CEP104

O60308

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Required for ciliogenesis and for structural integrity at the ciliary tip. {ECO:0000269|PubMed:23970417}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRNF213chr17:78337114chr1:3732934ENST00000508628+4169343_37439055257.0Coiled coilOntology_term=ECO:0000255
HgeneRNF213chr17:78337114chr1:3732934ENST00000582970+4068343_37438565208.0Coiled coilOntology_term=ECO:0000255
TgeneCEP104chr17:78337114chr1:3732934ENST0000037822307209_2890245.0Coiled coilOntology_term=ECO:0000255
TgeneCEP104chr17:78337114chr1:3732934ENST0000037822307677_7250245.0Coiled coilOntology_term=ECO:0000255
TgeneCEP104chr17:78337114chr1:3732934ENST0000037822307529_5670245.0RepeatNote=HEAT 1
TgeneCEP104chr17:78337114chr1:3732934ENST0000037822307604_6400245.0RepeatNote=HEAT 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRNF213chr17:78337114chr1:3732934ENST00000319921+117343_37401064.0Coiled coilOntology_term=ECO:0000255
HgeneRNF213chr17:78337114chr1:3732934ENST00000319921+1173997_403601064.0Zinc fingerRING-type
HgeneRNF213chr17:78337114chr1:3732934ENST00000508628+41693997_403639055257.0Zinc fingerRING-type
HgeneRNF213chr17:78337114chr1:3732934ENST00000582970+40683997_403638565208.0Zinc fingerRING-type
TgeneCEP104chr17:78337114chr1:3732934ENST000003782301922209_289857926.0Coiled coilOntology_term=ECO:0000255
TgeneCEP104chr17:78337114chr1:3732934ENST000003782301922677_725857926.0Coiled coilOntology_term=ECO:0000255
TgeneCEP104chr17:78337114chr1:3732934ENST000003782301922529_567857926.0RepeatNote=HEAT 1
TgeneCEP104chr17:78337114chr1:3732934ENST000003782301922604_640857926.0RepeatNote=HEAT 2


Top

Fusion Gene Sequence for RNF213-CEP104


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>74965_74965_1_RNF213-CEP104_RNF213_chr17_78337114_ENST00000336301_CEP104_chr1_3732934_ENST00000378230_length(transcript)=9315nt_BP=5787nt
ATGGTCTGTGATGGGGACTGGGAGCACTGCTACCTCCCCTCTGCCTTCAGCCAGCACAAGGTCTTCGTCACCCCCCAGGCACCCCTCGAG
GCCATCCAAGCCTACCTGGCAGGTCACTACCGGGTCCCGAAGCAGACCCTGTCGGCGGCAGCCGTGTTCAATGACCGGCTGTGTGTTGGG
ATCGTGGCCTCGGAGCGAGCAGGTGTTGGAAAGTCTCTGTACGTGAAGAGGTTGCACGACAAAATGAAGATGCAGTTAAACGTGAAAAAT
GTGCCTCTGAAAACAATTCGACTGATCGACCCTCAGGTGGATGAGAGCCGAGTCCTGGGCGCCCTGCTGCCCTTCCTGGATGCGCAGTAT
CAGAAGGTCCCCGTGCTCTTTCACCTGGACGTGACCTCCTCAGTGCAGACTGGAATTTGGGTGTTTCTTTTCAAGCTCCTCATTTTACAA
TACTTAATGGATATAAATGGGAAAATGTGGCTTCGGAACCCCTGCCATTTGTATATCGTTGAAATCCTGGAAAGGAGGACGTCAGTGCCG
TCGAGGAGCTCTTCAGCGCTGCGTACACGTGTACCCCAGTTCAGTTTTCTTGACATCTTCCCAAAAGTCACCTGCAGGCCTCCCAAAGAG
GTGATAGACATGGAGCTGAGTGCCCTGAGGAGTGACACAGAGCCTGGGATGGATCTGTGGGAGTTCTGCAGCGAAACTTTCCAAAGACCT
TACCAGTATTTAAGACGATTCAATCAAAACCAAGACCTAGACACGTTTCAGTATCAAGAAGGCTCTGTCGAAGGCACCCCGGAGGAATGC
CTCCAGCATTTCCTGTTTCACTGCGGGGTAATAAACCCATCCTGGTCAGAGCTTCGGAACTTTGCTCGGTTCCTGAATTATCAGCTCAGA
GATTGTGAGGCCTCTCTCTTCTGCAATCCGAGTTTTATTGGCGACACACTGAGGGGCTTCAAGAAGTTCGTGGTGACCTTCATGATCTTT
ATGGCAAGAGATTTTGCCACACCATCACTCCACACCTCTGACCAAAGCCCGGGGAAGCACATGGTCACCATGGATGGGGTTAGGGAAGAA
GATCTAGCGCCCTTCTCCCTCCGGAAGAGGTGGGAGTCGGAGCCTCACCCATACGTTTTCTTCAATGACGACCACACAACCATGACATTC
ATCGGCTTCCATCTGCAGCCCAACATCAACGGCAGTGTCGATGCCATCAGTCACTTGACTGGGAAGGTCATCAAGAGAGACGTCATGACC
AGGGACCTGTACCAGGGCCTGCTGCTCCAGAGGGTGCCCTTCAATGTCGACTTTGATAAACTGCCCAGACACAAGAAACTTGAGAGGCTC
TGCCTGACCTTAGGGATCCCCCAGGCCACCGACCCCGACAAAACGTATGAGCTCACAACCGACAATATGCTTAAAATCCTTGCCATCGAG
ATGCGGTTCCGGTGTGGGATCCCGGTTATCATCATGGGAGAAACTGGCTGTGGGAAAACCAGGCTTATTAAATTCCTTAGCGACCTGCGG
CGTGGTGGTACCAATGCTGACACCATAAAGCTGGTCAAGGTGCACGGAGGAACAACTGCAGACATGATCTACTCCAGAGTCAGGGAGGCT
GAAAATGTGGCCTTCGCCAATAAGGACCAACATCAGTTGGACACCATCTTGTTTTTTGATGAAGCCAACACAACGGAAGCTATAAGCTGT
ATCAAAGAAGTCCTGTGTGATCATATGGTGGATGGCCAGCCTCTGGCTGAGGACTCTGGCCTGCATATTATAGCTGCCTGCAATCCATAC
CGGAAGCACTCTGAGGAGATGATCTGCCGTTTGGAGTCAGCTGGTTTGGGCTACAGGGTTAGTATGGAGGAGACGGCCGACAGGCTGGGC
TCCATTCCTCTGAGGCAGCTGGTATACCGGGTCCATGCTCTGCCCCCGAGCCTGATTCCTCTGGTGTGGGACTTTGGACAACTGAGTGAC
GTTGCTGAAAAGCTCTACATCCAGCAGATTGTCCAGAGACTGGTTGAGTCCATCAGCCTAGATGAAAACGGGACTCGCGTGATCACAGAA
GTCCTCTGCGCCTCTCAGGGTTTCATGAGGAAAACAGAAGATGAGTGCAGCTTTGTCAGCCTCAGGGACGTGGAGCGCTGTGTGAAAGTT
TTCAGGTGGTTCCACGAGCACAGCGCGATGCTCTTAGCGCAGCTGAATGCCTTTCTCTCCAAGTCCAGCGTCAGCAAAAATCACACCGAG
AGAGATCCCGTCCTCTGGTCGTTGATGCTGGCCATCGGGGTGTGTTACCATGCCTCTTTAGAAAAGAAAGACTCATATCGGAAAGCCATC
GCCAGGTTCTTTCCGAAACCGTATGACGACAGCAGGCTGCTTCTGGATGAAATAACACGGGCACAGGATCTTTTTCTGGACGGCGTACCT
CTGAGGAAAACCATCGCCAAGAACTTGGCCTTGAAGGAGAACGTCTTCATGATGGTCGTCTGCATCGAGCTGAAGATTCCCCTCTTCCTG
GTGGGGAAGCCCGGCAGCTCCAAGTCTCTCGCCAAGACCATCGTGGCAGACGCCATGCAGGGCCCGGCTGCCTACTCAGATCTCTTCCGC
AGCCTGAAGCAGGTCCACCTGGTGTCCTTCCAGTGCAGCCCGCACTCCACCCCACAGGGCATCATCAGCACCTTCCGGCAGTGCGCCCGC
TTTCAGCAGGGGAAGGACCTGCAGCAGTACGTCTCTGTGGTGGTGTTAGATGAGGTGGGGCTGGCGGAAGACTCACCCAAAATGCCCCTG
AAGACTCTGCACCCGCTGCTGGAAGACGGATGCATTGAAGACGATCCCGCCCCCCACAAAAAGGTCGGCTTCGTGGGCATCTCCAACTGG
GCCCTTGACCCTGCCAAGATGAACCGGGGCATTTTTGTGTCACGTGGCAGCCCCAACGAGACAGAGCTCATAGAGAGCGCCAAGGGCATC
TGCTCCTCAGACATCCTCGTCCAGGACCGAGTCCAAGGGTACTTTGCGTCCTTTGCCAAAGCCTACGAAACGGTGTGTAAGCGCCAGGAC
AAGGAATTCTTCGGGCTTCGTGACTACTACAGCCTCATCAAAATGGTCTTTGCTGCAGCAAAGGCTTCAAATAGAAAGCCTTCCCCGCAA
GACATTGCACAGGCTGTCCTTAGGAACTTCAGTGGCAAGGATGACATCCAAGCTTTGGACATCTTTCTGGCCAATTTGCCCGAGGCCAAG
TGCTCAGAGGAAGTCAGCCCCATGCAGCTGATCAAACAGAACATCTTTGGGCCTTCTCAGAAGGTGCCGGGTGGAGAGCAGGAAGATGCT
GAGTCCCGCTACTTACTCGTGCTGACCAAAAACTACGTGGCACTGCAGATCCTGCAGCAGACATTCTTCGAGGGGGACCAGCAGCCGGAG
ATTATTTTTGGTTCTGGTTTCCCCAAGGACCAAGAGTACACCCAGCTCTGCAGAAACATCAATCGTGTGAAGATCTGCATGGAAACAGGC
AAGATGGTGTTGCTTCTCAACCTGCAGAACCTCTACGAGAGCCTCTACGACGCACTCAACCAGTACTACGTCCACCTCGGCGGCCAGAAG
TACGTGGACCTCGGTCTGGGGACCCACCGCGTCAAATGTCGGGTTCACCCCAACTTCCGCCTGATTGTCATTGAAGAGAAAGACGTCGTG
TACAAACACTTTCCCATCCCCCTCATTAACCGGCTGGAGAAGCACTATCTGGATATCAACACGGTGCTGGAGAAATGGCAGAAGAGCATC
GTGGAGGAGCTCTGTGCGTGGGTGGAGAAGTTCATCAATGTCAAAGCACATCATTTCCAGAAGAGGCACAAATACAGCCCCTCTGACGTC
TTCATCGGCTACCACTCGGACGCCTGCGCGTCTGTGGTGCTGCAGGTCATAGAGAGGCAGGGTCCCCGGGCCTTGACGGAGGAACTTCAC
CAGAAGGTGTCTGAGGAGGCCAAATCGATCCTGCTGAACTGCGCTACGCCCGATGCCGTGGTCCGGCTGAGCGCCTACTCGCTGGGCGGG
TTCGCAGCGGAGTGGCTGTCGCAGGAGTACTTTCACAGACAGAGGCACAACTCCTTTGCAGATTTCCTTCAGGCACACCTGCACACGGCA
GACCTGGAGCGCCACGCCATCTTCACAGAGATCACCACTTTCTCCAGGCTGCTAACAAGTCACGACTGTGAAATTTTAGAATCAGAGGTC
ACAGGCAGGGCTCCGAAACCCACACTCCTGTGGCTGCAGCAGTTTGACACCGAGTACTCATTCCTCAAAGAAGTCCGAAACTGTTTAACG
AATACAGCCAAATGTAAAATCCTCATTTTTCAGACAGATTTTGAAGATGGAATCCGTAGCGCCCAGCTCATTGCCTCAGCTAAGTATTCT
GTTATAAATGAAATCAACAAAATACGAGAAAATGAGGACCGTATCTTCGTCTATTTCATCACAAAACTGTCCCGGGTGGGAAGAGGAACA
GCCTATGTGGGCTTCCACGGAGGGCTGTGGCAGTCTGTCCACATCGATGACCTCCGGAGATCCACCCTCATGGTTTCTGATGTGACCAGG
CTGCAGCATGTCACCATCAGCCAGCTGTTCGCGCCCGGAGACTTGCCTGAGCTGGGCTTGGAACACCGGGCGGAAGACGGCCATGAGGAG
GCGATGGAGACGGAGGCCAGCACATCAGGGGAGGTGGCAGAGGTGGCAGAGGAGGCCATGGAAACAGAAAGTTCTGAGAAGGTGGGAAAG
GAAACCTCTGAACTCGGAGGCAGTGATGTGTCGATCCTGGACACCACCAGGCTGCTGAGAAGCTGTGTGCAGAGCGCCGTGGGCATGCTC
AGAGACCAGAACGAGAGCTGCACGCGCAATATGCGGAGGGTGGTGCTCCTCCTGGGCCTCTTGAATGAGGATGACGCGTGCCACGCCTCT
TTCTTGCGGGTATCCAAGATGCGCCTCAGTGTCTTTTTAAAGAAGCAAGAAGAGAGCCAGTTTCACCCTCTGGAGTGGTTGGCAAGGGAA
GCCTGCAACCAGGACGCTCTCCAGGAGGCGGGCACATTCAGGCACACCCTCTGGAAGCGGGTCCAAGGTGCTGTCACCCCTCTGCTGGCG
AGCATGATATCATTCATCGACAGAGACGGCAACCTAGAGTTACTGACCAGGCCAGATACTCCGCCCTGGGCAAGAGATCTTTGGATGTTT
ATTTTCAGTGACACGATGCTTCTGAACATTCCTCTTGTGATGAATAATGAAAGACATAAAGGTGAGATGGCCTACATCGTGGTGCAGAAC
CACATGAACCTTTCCGAGAACGCTTCCAACAACGTCCCTTTCAGCTGGAAAATCAAGGACTATCTGGAGGAGCTGTGGGTCCAGGCTCAG
TACATCACAGACGCAGAAGGACTGCCCAAGAAGTTCGTGGACATCTTTCAGCAGACTCCTCTGGGCAGGTTTCTTGCCCAGCTCCATGGA
GAGCCGCAGCAGGAACTTCTTCAGTGTTACTTGAAGGATTTCATTCTCTTGACCATGCGTGTGTCAACGGAGGAGGAATTAAAGTTTCTG
CAGATGGCTCTGTGGTCCTGCACTAGGAAACTGAAAGCGGCGTCAGAAGCGCCCGAGGAAGAGGTTTCCTTACCGTGGGTGCACCTTGCC
TACCAGCGTTTCAGAAGCCGTCTGCAGAACTTTTCCAGAATCCTGACCATCTACCCTCAGGTTCTCCACAGCCTGATGGAAGCCCGTTGG
AACCATGAGCTGGCTGGATGTGAGATGGCATGGAAAGCTCACCTGATGGGCCCAGCCGGCTGCACGATGAACCTGCGCAAGACACACATT
CTGCAGAAGGCCCCGGCACTGCAGCCAGGGAAAAGCTCAGCTGTGGCCGCATCAGGCCCCTTGGGGTCAAAGGCCGGAAGCAAGATCCCC
ACCCCGAAGGGCGGACTGAGCAAGAGCTCCAGCAGGACGTACGCCAAGCGCTGACGCGGCGCTCGGGCTCCTTGGTCTCTGTGAGGGATG
GAGCGGGTCTCCTGATTCTACACCATCTCTCCAGAACTCTCTGGCCTTGGTGGCCCCATGCTCTGGCTGCTGTCCCCAGCTCCCCGCCGT
GCACGCCTCTTACGCGTCTGTGCCGTCAGCTCTCGTGCAAACGATATGGATGCAGCTAACCAAAGATCCTGCGTGCAGTGCCAGGACCTG
GCCGCACTGTACATTAAGCCTTCAGGGCTGTCTCAGGCCTTCCTTAGAATCAGAGAAGGAAGCGTCCTGTTTGGAGAGAGCCAGAGAGCA
CCGCCGGGAGGCGCTCGCGCAAGGCCACGGTCAGCACAGGCACGGTCCCGCTTTCCTTAGTGCTTGGAGCAATTTCCATAAAACATTCAC
CAGAAACCTTTTGCACATCGGTCTCTGCCACACGCAGTAGAATTTCCGCAGGGCTGTGGCTCGGCCAGCAGCGGTTCCAGGAGAGTGGCG
GTGCGCACGGGCCTCCAGCCGTGCCTTCCCCCTGCAGGCCCCGTCTGCTGGGCCTGCTGCCCAGTGCACTCAGCCCCAGGTAGCAGAACT
CACGTTCCCACTATAGCAAGAAATAAAGGCAAAAGAGAACATCTTTTTTTTAATCGTAGTTTTTTTGAGAATTGGTCCCACCTCAGCCGC
ACCTTGCTGGATGCTTCTCCAGTAGTGCTGCCCCTGTGACAGGCATCAGCTCCCTGCTGGAACTGAGGTAGACACAGGTGTGGGCCCTTC
CCGTGCCTTTGCTCAGAGGCGCTTCACTTTCTCCACACTTTCGAATTCCTAAAGACATGTGGAGGAAGTCACTGTTAAATGAATTTCCAC
CTGATCACCCTGTGTTCACAGCAGGCAGAAGCCCACTGGTATGGGCCTCCCGCCCCTTCCACATCCATGTTGTGATTGGATCCATAAGTT
TACTTTCTTCAAAGAGTTGATAGGATGTTTAAAACATCAACACATTGCTTAAAATGATGAAACCAACCCTCAAAAAACAGTCTCCTAACC
AGCCATCCCCTCCTGTGGGAGTGAGCTGGGGGTTTTGTCCATAGCTTTGGTTGGGCCTGTGTCACATCCAGGCAGCCATGTGGAGGGAGT
CAGGGTCTGTCTGGAAGCATCCACCCTCTCGCTGCCCCAGCCTGTGCTCCCAGGGGCCTAGGCTACCATGGACTGAAGGGCAGTCCCCTC
CCACCTGGTGCCCAGGGCTTCTGCTTGCCTCGCTGATGTTGCATGGGCAGACTTCAAAAAGGATAGTTAGAAAGGTTTGGGTTGATGGAG
TTTGCATTAATGCAATTAGTGTATAAATATGTTTTAATTGCCAACCGTGTGAAACAACAAAATATCTAAAAACTAATCCCGATTTGAACA
ATGTACTCCCTGGCCTGGATACATTAATAACCATAAATTTGCATGAATTAATCTCCACGTTTGGTAAACTAATACCTCTGGTTGACTGAG
AATACTGAGTAAGATATAAGACCTACCAGGAACCTTTAAGAATATGCTCTGCTCAGTGTTGTTTGTCTGCTTGTTTGCGACGGAGTCTCA
CTGTGTCGCCCGGGCTGCAGTGCAATGGCGTGATCTTGGCTCACAGTAACCTCCACCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCT
CCCTAGTAGCTGGGATTACAGGTGCACACCACCATGCTCGGCTAATTTTTTCTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAG
GCTGGTCTCGAACTCGTGACCTCATAATCTGCCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCACGCCCAGGTTAA
ATGTGTTTATAAGGAGAGAGGAGGCCAGGCGCGGTGGCTCACGCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGACCACCTGAG
GTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATGAGCCAGGCGTGGTGGCCTGTAGTC
CCAGCTACTTGAGAGGCTGAGGCAGGAAAATTGCTTGAACCCGGGAGGTGGAGGTTGCATTGAGCCCACATCATGCCATTGCACTCCAGC
CCAGGCGACAGAGCGAGACTCCGTCTCGAAAAAAAAAAAAAGTATAAGGAGAGAAATAACTTTAAAGTTTATTAGACAAAACAGAGTATA
GATGCCAAGATGTCTGTAAAATGATTTTTTCTGGTTTTAAAGAGATGTTGGCCATTATTTTCTAATCCATTTTTAAAATACAGACAAAAC
ACTTCTTTAAACAGAACAAGAATGAGAAAAGTTAACCAAGGAATTATTCTTTTCTCACCAATCAACACTTTTAAGAAATATATATATATA
TATACACACATATACACATGCCTTCTATATATTGTAACTTAAAGAAAATACTTATAAAAAGACTTCATTTTTAGTGATTGACAAGCAAAC
GGGTTCATTTAAAACAGGTTCCTCTTTTGTTAGTTACAGGGGGTTTTTTTGTTGTTTTTTTGTTTTTGTTTTTGTTTTGCGGGGGTGGTG
GGGTTTGAGACGGAGTCTTGCTCTGTTGCCTAGGCTGGAGTGCAGTGGCGCGATCTTGGCCCCCTGCAACCTCCGCCTCCCGGGTTCGAG
CAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCGTGTGTCACCACGCCTGGCTAATTTTTTTGTATTTTTAGTAGAGACG
GGGTTTCACCATATTGGCCAGGCTGGTCTCAAACTCCTGACCTTGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGAATTACAGGCAT
GAGCCACCGCGCCCGGCCCAATCATGTGTTTTTGTTGAAATGATCCTACCAGTGATTAGTGGCTATTGAGAGTTTTACAGGGTTATACAT
TGTTAAGGGACCAAGAATCAAGTACAAAAAATTAAAAAGGAACTGTAAAATCCCTTGGTCATTCATAAATAAATATCTAAATTAGGAATA
CTAATTAATTGAATTTTCACTCATGAGTATGTTCTGAATATTTAATATTTATTTCTATTATTTTCATATGTTAAGATATTCCATTAAATC
TAACTTAAAAGAATTGTATGTATAAATTGGCATTAGGATACAAATGTAAATGTTTTTAATGAAATTTTGCAACTTTTTAATATTTTAACA
TAGTTTTCTATTTGTCTTTATTTCAAGTACCAGAATTACAAAATATCTAAGTAATATATTTTTGTTGTCGTTTTAGGGCTTAAGGGTTAA

>74965_74965_1_RNF213-CEP104_RNF213_chr17_78337114_ENST00000336301_CEP104_chr1_3732934_ENST00000378230_length(amino acids)=1997AA_BP=1929
MVCDGDWEHCYLPSAFSQHKVFVTPQAPLEAIQAYLAGHYRVPKQTLSAAAVFNDRLCVGIVASERAGVGKSLYVKRLHDKMKMQLNVKN
VPLKTIRLIDPQVDESRVLGALLPFLDAQYQKVPVLFHLDVTSSVQTGIWVFLFKLLILQYLMDINGKMWLRNPCHLYIVEILERRTSVP
SRSSSALRTRVPQFSFLDIFPKVTCRPPKEVIDMELSALRSDTEPGMDLWEFCSETFQRPYQYLRRFNQNQDLDTFQYQEGSVEGTPEEC
LQHFLFHCGVINPSWSELRNFARFLNYQLRDCEASLFCNPSFIGDTLRGFKKFVVTFMIFMARDFATPSLHTSDQSPGKHMVTMDGVREE
DLAPFSLRKRWESEPHPYVFFNDDHTTMTFIGFHLQPNINGSVDAISHLTGKVIKRDVMTRDLYQGLLLQRVPFNVDFDKLPRHKKLERL
CLTLGIPQATDPDKTYELTTDNMLKILAIEMRFRCGIPVIIMGETGCGKTRLIKFLSDLRRGGTNADTIKLVKVHGGTTADMIYSRVREA
ENVAFANKDQHQLDTILFFDEANTTEAISCIKEVLCDHMVDGQPLAEDSGLHIIAACNPYRKHSEEMICRLESAGLGYRVSMEETADRLG
SIPLRQLVYRVHALPPSLIPLVWDFGQLSDVAEKLYIQQIVQRLVESISLDENGTRVITEVLCASQGFMRKTEDECSFVSLRDVERCVKV
FRWFHEHSAMLLAQLNAFLSKSSVSKNHTERDPVLWSLMLAIGVCYHASLEKKDSYRKAIARFFPKPYDDSRLLLDEITRAQDLFLDGVP
LRKTIAKNLALKENVFMMVVCIELKIPLFLVGKPGSSKSLAKTIVADAMQGPAAYSDLFRSLKQVHLVSFQCSPHSTPQGIISTFRQCAR
FQQGKDLQQYVSVVVLDEVGLAEDSPKMPLKTLHPLLEDGCIEDDPAPHKKVGFVGISNWALDPAKMNRGIFVSRGSPNETELIESAKGI
CSSDILVQDRVQGYFASFAKAYETVCKRQDKEFFGLRDYYSLIKMVFAAAKASNRKPSPQDIAQAVLRNFSGKDDIQALDIFLANLPEAK
CSEEVSPMQLIKQNIFGPSQKVPGGEQEDAESRYLLVLTKNYVALQILQQTFFEGDQQPEIIFGSGFPKDQEYTQLCRNINRVKICMETG
KMVLLLNLQNLYESLYDALNQYYVHLGGQKYVDLGLGTHRVKCRVHPNFRLIVIEEKDVVYKHFPIPLINRLEKHYLDINTVLEKWQKSI
VEELCAWVEKFINVKAHHFQKRHKYSPSDVFIGYHSDACASVVLQVIERQGPRALTEELHQKVSEEAKSILLNCATPDAVVRLSAYSLGG
FAAEWLSQEYFHRQRHNSFADFLQAHLHTADLERHAIFTEITTFSRLLTSHDCEILESEVTGRAPKPTLLWLQQFDTEYSFLKEVRNCLT
NTAKCKILIFQTDFEDGIRSAQLIASAKYSVINEINKIRENEDRIFVYFITKLSRVGRGTAYVGFHGGLWQSVHIDDLRRSTLMVSDVTR
LQHVTISQLFAPGDLPELGLEHRAEDGHEEAMETEASTSGEVAEVAEEAMETESSEKVGKETSELGGSDVSILDTTRLLRSCVQSAVGML
RDQNESCTRNMRRVVLLLGLLNEDDACHASFLRVSKMRLSVFLKKQEESQFHPLEWLAREACNQDALQEAGTFRHTLWKRVQGAVTPLLA
SMISFIDRDGNLELLTRPDTPPWARDLWMFIFSDTMLLNIPLVMNNERHKGEMAYIVVQNHMNLSENASNNVPFSWKIKDYLEELWVQAQ
YITDAEGLPKKFVDIFQQTPLGRFLAQLHGEPQQELLQCYLKDFILLTMRVSTEEELKFLQMALWSCTRKLKAASEAPEEEVSLPWVHLA
YQRFRSRLQNFSRILTIYPQVLHSLMEARWNHELAGCEMAWKAHLMGPAGCTMNLRKTHILQKAPALQPGKSSAVAASGPLGSKAGSKIP

--------------------------------------------------------------
>74965_74965_2_RNF213-CEP104_RNF213_chr17_78337114_ENST00000508628_CEP104_chr1_3732934_ENST00000378230_length(transcript)=15388nt_BP=11860nt
GACAGCGCGCGGCAGGCGGCGAGCTCGGGGGCCGCAGAAAATGAAACTGAAGCCGTGGTCACGTGACAGGACATGTAGTATATAGCAGGC
TGCCAGCGACTCCTGCTCTTGCTTCTGGATCTGCAGGGCAGTCCCAGCAGGACCCATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGA
GGAAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCCATAGCAGATTCTGAGAACAATAACTCCACAATGGC
GTCGGCCTCGGAGGGTGAAATGGAGTGTGGGCAGGAGCTGAAGGAGGAAGGGGGCCCGTGCTTGTTCCCGGGCTCAGACAGTTGGCAAGA
AAACCCCGAGGAGCCCTGTTCCAAAGCCTCCTGGACCGTCCAAGAAGGAGCTACATCAGAGGTTTTGGTAGATGCTGCTGTAGACCTCAT
ATCCGATGAATGGGAAGCTGCTAATGCCATACCCAGCAAGAGAAGGAAGCAGGATGCAGCCCCGCTTGAGGCCGCCAGCGTGCCTTCTGC
AGACTGTGAGCAGAGCAAAAAGAAGAAAAGGAAGAAGAAAAAGAAGGGGAACAAGTCCGCTTCCTCAGAGCTGGCTTCCTTGCCCCTTTC
TCCTGCCAGCCCCTGTCACCTGACTTTGCTTTCAAACCCGTGGCCTCAGGACACAGCCCTGCCCCACAGCCAAGCCCAGCAGAGTGGCCC
CACTGGCCAGCCGAGCCAGCCCCCAGGCACAGCCACCACGCCACTGGAGGGTGACGGCCTCTCCGCGCCCACCGAGGTTGGCGACAGCCC
CCTGCAGGCCCAGGCTTTGGGAGAGGCAGGAGTGGCCACAGGAAGTGAGGCTCAGAGCAGCCCGCAATTCCAGGACCACACGGAAGGGGA
GGACCAGGACGCTTCCATCCCCTCTGGGGGCAGAGGCCTGTCCCAGGAGGGGACCGGTCCCCCCACCTCTGCTGGTGAAGGCCATTCTAG
GACTGAAGATGCTGCCCAGGAGCTCCTGTTGCCTGAGTCAAAAGGAGGCAGCTCTGAGCCCGGGACAGAACTGCAGACCACCGAGCAACA
GGCAGGGGCCTCAGCCTCTATGGCAGTTGATGCTGTAGCTGAGCCAGCCAATGCAGTTAAAGGGGCCGGGAAGGAAATGAAAGAGAAGAC
CCAGAGAATGAAACAGCCACCAGCAACCACTCCTCCTTTCAAAACACACTGCCAGGAAGCTGAGACCAAGACCAAGGACGAGATGGCTGC
TGCTGAAGAAAAAGTCGGTAAGAATGAACAAGGGGAGCCTGAAGACCTCAAGAAGCCAGAGGGGAAGAACAGAAGTGCAGCTGCTGTGAA
AAACGAGAAGGAGCAAAAAAACCAGGAAGCAGATGTCCAGGAAGTGAAGGCAAGCACGCTGAGCCCGGGTGGAGGAGTCACCGTGTTCTT
CCACGCCATCATCTCTCTTCATTTCCCATTCAATCCTGACCTCCATAAAGTCTTCATCAGAGGAGGAGAAGAATTTGGGGAGTCAAAATG
GGACAGCAATATCTGTGAGCTGCACTACACCAGAGACTTGGGTCATGACCGCGTTCTTGTTGAAGGCATTGTCTGCATTTCCAAGAAGCA
CCTAGATAAATACATTCCTTACAAGTACGTCATTTATAATGGGGAATCTTTTGAGTATGAGTTCATTTACAAGCACCAGCAGAAGAAGGG
CGAGTACGTCAACCGCTGTCTGTTCATAAAATCTTCACTTCTGGGCTCAGGAGACTGGCATCAGTACTATGACATAGTTTATATGAAGCC
TCATGGGAGACTCCAGAAAGTCATGAACCACATCACAGACGGGCCGAGGAAGGACCTGGTGAAGGGGAAGCAGATTGCCGCTGCGCTCAT
GCTGGACAGCACCTTCAGCATCCTGCAGACCTGGGACACCATCAACCTGAACAGCTTCTTCACCCAGTTCGAGCAGTTTTGCTTTGTCCT
GCAACAGCCTATGATTTATGAAGGACAGGCACAGCTGTGGACCGATTTGCAGTACAGGGAGAAAGAGGTGAAGAGATACCTGTGGCAACA
TCTGAAAAAACACGTGGTACCATTGCCGGACGGAAAAAGCACGGACTTTTTGCCTGTGGACTGCCCAGTGAGGAGTAAACTGAAAACAGG
CCTGATTGTCCTTTTTGTAGTGGAAAAAATTGAGCTTTTATTAGAAGGCAGCCTGGACTGGTTGTGTCACCTCCTAACCTCAGATGCCAG
CTCACCAGATGAGTTTCACCGTGACCTAAGCCACATCCTTGGGATACCTCAGAGCTGGCGGCTGTACCTGGTGAACCTGTGCCAAAGATG
CATGGACACAAGGACGTACACCTGGCTGGGCGCCCTGCCTGTCCTGCACTGCTGTATGGAGCTGGCCCCGCGGCACAAGGATGCCTGGAG
ACAGCCTGAGGACACCTGGGCCGCTCTGGAGGGACTCTCCTTCTCACCGTTCCGGGAACAAATGCTAGATACGAGTTCCCTACTTCAGTT
TATGAGAGAGAAGCAGCATTTGCTGAGCATAGACGAGCCTCTCTTCCGGTCCTGGTTTAGTCTGCTACCTCTGAGTCACCTGGTTATGTA
TATGGAAAACTTCATTGAGCACCTGGGTCGTTTTCCTGCTCATATCCTGGACTGTCTTTCAGGGATTTACTACCGGCTTCCGGGACTTGA
GCAAGTCTTGAATACGCAGGATGTTCAGGATGTTCAGAACGTTCAGAACATTTTAGAAATGCTGTTGCGACTCCTGGACACTTACCGGGA
CAAGATTCCCGAGGAGGCCTTGTCACCATCCTACCTGACTGTGTGTCTGAAACTGCATGAAGCCATCTGCAGCAGCACAAAGCTACTTAA
GTTTTACGAGCTGCCAGCCTTATCTGCCGAGATTGTCTGCAGAATGATTAGACTTCTATCTCTGGTGGATTCTGCAGGACAGAGAGATGA
AACTGGAAATAATTCAGTCCAAACAGTCTTCCAAGGGACCCTTGCTGCTACGAAAAGGTGGCTCCGAGAAGTTTTTACAAAGAACATGCT
CACATCTTCAGGTGCCTCATTCACATACGTCAAGGAAATTGAGGTCTGGAGGCGGCTGGTGGAAATCCAATTCCCCGCGGAGCATGGCTG
GAAGGAGTCGTTGCTGGGAGACATGGAATGGAGGCTCACAAAGGAGGAACCCCTCTCCCAGATCACTGCCTACTGCAATAGTTGCTGGGA
CACCAAAGGCTTAGAGGACAGTGTGGCCAAGACCTTCGAGAAATGCATCATTGAAGCCGTGAGCTCAGCCTGCCAGTCTCAGACCAGTAT
CCTTCAGGGGTTCTCTTACTCTGATTTGCGGAAATTTGGCATCGTCTTGTCTGCTGTGATCACTAAGTCCTGGCCTAGGACCGCGGACAA
CTTCAATGACATTTTAAAGCATCTGCTCACGTTGGCAGATGTCAAGCACGTCTTCAGATTGTGTGGAACCGACGAGAAAATACTAGCAAA
TGTCACAGAGGATGCCAAGAGGCTGATAGCTGTTGCCGACTCTGTGTTGACGAAAGTTGTTGGTGACCTCCTAAGTGGCACGATTTTAGT
TGGACAACTGGAGCTGATTATAAAGCACAAGAATCAGTTTCTTGACATCTGGCAACTGAGGGAAAAAAGTCTTTCACCCCAGGATGAACA
ATGTGCTGTGGAGGAAGCACTGGATTGGAGAAGGGAGGAACTGTTACTTCTAAAGAAAGAGAAAAGATGTGTTGATAGTCTCCTGAAGAT
GTGTGGGAACGTGAAACATCTGATACAAGTGGACTTTGGAGTGCTTGCAGTAAGACACTCACAAGACCTCAGCAGTAAAAGATTAAATGA
CACCGTGACAGTGAGACTGTCCACCTCCTCGAACTCGCAGAGGGCAACGCATTACCACCTGAGCTCCCAGGTCCAAGAAATGGCTGGGAA
GATAGACTTGCTCAGAGACAGCCACATCTTCCAGCTCTTCTGGCGGGAAGCCGCAGAGCCGCTGAGTGAGCCTAAGGAGGACCAGGAAGC
CGCAGAGTTGCTGAGTGAGCCCGAAGAAGAATCAGAAAGGCACATCCTTGAGCTTGAAGAGGTGTATGACTATTTGTATCAGCCTTCTTA
CAGAAAGTTCATTAAGTTGCACCAGGATCTAAAGTCAGGAGAGGTCACCCTTGCAGAGATTGATGTCATCTTCAAGGACTTTGTGAATAA
ATACACGGACCTGGATTCAGAACTTAAGATCATGTGCACCGTGGACCACCAGGACCAAAGAGATTGGATCAAGGACCGAGTCGAACAGAT
CAAGGAATACCATCACCTGCACCAGGCTGTCCACGCAGCCAAGGTCATCTTGCAGGTCAAAGAGAGCCTGGGACTGAACGGTGACTTCAG
TGTTCTCAACACTTTACTAAATTTTACTGATAACTTCGACGACTTTCGCCGTGAAACACTGGACCAGATCAACCAGGAGCTCATCCAGGC
CAAAAAGCTGCTCCAGGACATCAGCGAGGCCCGGTGCAAGGGGCTGCAGGCTCTGTCCCTGAGAAAGGAGTTCATCTGCTGGGTCCGGGA
GGCTCTTGGAGGCATCAATGAGCTGAAGGTGTTTGTGGACCTGGCCTCCATCTCAGCGGGGGAGAATGACATTGATGTGGACCGGGTGGC
CTGCTTCCATGACGCTGTGCAGGGCTACGCATCCCTGCTATTTAAGCTGGACCCCAGCGTGGACTTCAGTGCATTCATGAAGCATCTGAA
AAAGCTGTGGAAGGCTCTGGATAAGGACCAGTACCTGCCCAGGAAACTGTGTGACTCCGCCAGGAACTTGGAATGGCTGAAGACTGTGAA
TGAGAGTCATGGGTCTGTGGAACGCTCATCCCTGACCCTGGCCACGGCCATCAACCAAAGAGGCATCTATGTGATCCAGGCGCCCAAAGG
TGGCCAAAAGATTTCCCCAGACACGGTTCTGCACTTGATCCTTCCTGAGAGCCCTGGCAGCCACGAGGAGTCACGAGAGTACTCTTTAGA
GGAGGTGAAGGAGCTTTTGAACAAGTTGATGCTGATGTCTGGCAAGAAGGATCGTAACAACACGGAAGTGGAGAGGTTTTCAGAGGTCTT
CTGCAGTGTGCAGAGGCTCAGCCAGGCCTTCATCGACCTGCACTCTGCTGGGAATATGCTGTTCAGGACGTGGATCGCCATGGCCTACTG
CTCCCCCAAGCAGGGTGTGTCCCTCCAAATGGACTTTGGCTTGGACCTGGTGACGGAGCTTAAAGAAGGTGGAGATGTCACTGAGCTGCT
GGCAGCCCTCTGCAGGCAGATGGAGCACTTCCTTGACAGCTGGAAGAGATTTGTGACCCAGAAGCGAATGGAGCACTTTTACCTGAACTT
CTACACGGCAGAGCAGCTGGTTTACCTGAGCACTGAGCTCAGGAAGCAGCCCCCGAGTGATGCCGCCCTAACGATGCTATCCTTCATCAA
AAGCAACTGCACCCTGAGGGATGTCTTAAGGGCCTCTGTGGGGTGTGGGAGTGAGGCCGCCAGGTACCGCATGAGGAGAGTCATGGAAGA
GCTCCCGCTGATGCTCTTATCAGAGTTCAGCCTGGTGGACAAGCTGAGGATCATCATGGAGCAGTCCATGAGGTGCCTTCCTGCCTTCCT
GCCCGACTGCCTCGACCTAGAGACCCTTGGCCACTGTCTGGCTCACCTGGCAGGGATGGGTGGGTCTCCCGTGGAGCGTTGTCTCCCGAG
AGGTCTGCAGGTCGGCCAGCCCAACCTCGTCGTCTGTGGCCACTCCGAGGTGTTGCCAGCCGCCCTGGCTGTCTACATGCAAACCCCAAG
CCAGCCCCTGCCCACTTACGATGAGGTGCTGCTCTGCACCCCGGCAACCACCTTTGAGGAGGTGGCACTGTTGCTGCGCCGCTGCCTGAC
CCTGGGCTCCCTGGGGCACAAGGTCTACAGCCTGCTGTTCGCAGATCAGCTGAGCTACGAGGTGGCACGCCAAGCGGAGGAGCTTTTCCA
CAATCTGTGCACGCAGCAGCACCGAGAAGACTACCAGCTCGTCATGGTCTGTGATGGGGACTGGGAGCACTGCTACCTCCCCTCTGCCTT
CAGCCAGCACAAGGTCTTCGTCACCCCCCAGGCACCCCTCGAGGCCATCCAAGCCTACCTGGCAGGTCACTACCGGGTCCCGAAGCAGAC
CCTGTCGGCGGCAGCCGTGTTCAATGACCGGCTGTGTGTTGGGATCGTGGCCTCGGAGCGAGCAGGTGTTGGAAAGTCTCTGTACGTGAA
GAGGTTGCACGACAAAATGAAGATGCAGTTAAACGTGAAAAATGTGCCTCTGAAAACAATTCGACTGATCGACCCTCAGGTGGATGAGAG
CCGAGTCCTGGGCGCCCTGCTGCCCTTCCTGGATGCGCAGTATCAGAAGGTCCCCGTGCTCTTTCACCTGGACGTGACCTCCTCAGTGCA
GACTGGAATTTGGGTGTTTCTTTTCAAGCTCCTCATTTTACAATACTTAATGGATATAAATGGGAAAATGTGGCTTCGGAACCCCTGCCA
TTTGTATATCGTTGAAATCCTGGAAAGGAGGACGTCAGTGCCGTCGAGGAGCTCTTCAGCGCTGCGTACACGTGTACCCCAGTTCAGTTT
TCTTGACATCTTCCCAAAAGTCACCTGCAGGCCTCCCAAAGAGGTGATAGACATGGAGCTGAGTGCCCTGAGGAGTGACACAGAGCCTGG
GATGGATCTGTGGGAGTTCTGCAGCGAAACTTTCCAAAGACCTTACCAGTATTTAAGACGATTCAATCAAAACCAAGACCTAGACACGTT
TCAGTATCAAGAAGGCTCTGTCGAAGGCACCCCGGAGGAATGCCTCCAGCATTTCCTGTTTCACTGCGGGGTAATAAACCCATCCTGGTC
AGAGCTTCGGAACTTTGCTCGGTTCCTGAATTATCAGCTCAGAGATTGTGAGGCCTCTCTCTTCTGCAATCCGAGTTTTATTGGCGACAC
ACTGAGGGGCTTCAAGAAGTTCGTGGTGACCTTCATGATCTTTATGGCAAGAGATTTTGCCACACCATCACTCCACACCTCTGACCAAAG
CCCGGGGAAGCACATGGTCACCATGGATGGGGTTAGGGAAGAAGATCTAGCGCCCTTCTCCCTCCGGAAGAGGTGGGAGTCGGAGCCTCA
CCCATACGTTTTCTTCAATGACGACCACACAACCATGACATTCATCGGCTTCCATCTGCAGCCCAACATCAACGGCAGTGTCGATGCCAT
CAGTCACTTGACTGGGAAGGTCATCAAGAGAGACGTCATGACCAGGGACCTGTACCAGGGCCTGCTGCTCCAGAGGGTGCCCTTCAATGT
CGACTTTGATAAACTGCCCAGACACAAGAAACTTGAGAGGCTCTGCCTGACCTTAGGGATCCCCCAGGCCACCGACCCCGACAAAACGTA
TGAGCTCACAACCGACAATATGCTTAAAATCCTTGCCATCGAGATGCGGTTCCGGTGTGGGATCCCGGTTATCATCATGGGAGAAACTGG
CTGTGGGAAAACCAGGCTTATTAAATTCCTTAGCGACCTGCGGCGTGGTGGTACCAATGCTGACACCATAAAGCTGGTCAAGGTGCACGG
AGGAACAACTGCAGACATGATCTACTCCAGAGTCAGGGAGGCTGAAAATGTGGCCTTCGCCAATAAGGACCAACATCAGTTGGACACCAT
CTTGTTTTTTGATGAAGCCAACACAACGGAAGCTATAAGCTGTATCAAAGAAGTCCTGTGTGATCATATGGTGGATGGCCAGCCTCTGGC
TGAGGACTCTGGCCTGCATATTATAGCTGCCTGCAATCCATACCGGAAGCACTCTGAGGAGATGATCTGCCGTTTGGAGTCAGCTGGTTT
GGGCTACAGGGTTAGTATGGAGGAGACGGCCGACAGGCTGGGCTCCATTCCTCTGAGGCAGCTGGTATACCGGGTCCATGCTCTGCCCCC
GAGCCTGATTCCTCTGGTGTGGGACTTTGGACAACTGAGTGACGTTGCTGAAAAGCTCTACATCCAGCAGATTGTCCAGAGACTGGTTGA
GTCCATCAGCCTAGATGAAAACGGGACTCGCGTGATCACAGAAGTCCTCTGCGCCTCTCAGGGTTTCATGAGGAAAACAGAAGATGAGTG
CAGCTTTGTCAGCCTCAGGGACGTGGAGCGCTGTGTGAAAGTTTTCAGGTGGTTCCACGAGCACAGCGCGATGCTCTTAGCGCAGCTGAA
TGCCTTTCTCTCCAAGTCCAGCGTCAGCAAAAATCACACCGAGAGAGATCCCGTCCTCTGGTCGTTGATGCTGGCCATCGGGGTGTGTTA
CCATGCCTCTTTAGAAAAGAAAGACTCATATCGGAAAGCCATCGCCAGGTTCTTTCCGAAACCGTATGACGACAGCAGGCTGCTTCTGGA
TGAAATAACACGGGCACAGGATCTTTTTCTGGACGGCGTACCTCTGAGGAAAACCATCGCCAAGAACTTGGCCTTGAAGGAGAACGTCTT
CATGATGGTCGTCTGCATCGAGCTGAAGATTCCCCTCTTCCTGGTGGGGAAGCCCGGCAGCTCCAAGTCTCTCGCCAAGACCATCGTGGC
AGACGCCATGCAGGGCCCGGCTGCCTACTCAGATCTCTTCCGCAGCCTGAAGCAGGTCCACCTGGTGTCCTTCCAGTGCAGCCCGCACTC
CACCCCACAGGGCATCATCAGCACCTTCCGGCAGTGCGCCCGCTTTCAGCAGGGGAAGGACCTGCAGCAGTACGTCTCTGTGGTGGTGTT
AGATGAGGTGGGGCTGGCGGAAGACTCACCCAAAATGCCCCTGAAGACTCTGCACCCGCTGCTGGAAGACGGATGCATTGAAGACGATCC
CGCCCCCCACAAAAAGGTCGGCTTCGTGGGCATCTCCAACTGGGCCCTTGACCCTGCCAAGATGAACCGGGGCATTTTTGTGTCACGTGG
CAGCCCCAACGAGACAGAGCTCATAGAGAGCGCCAAGGGCATCTGCTCCTCAGACATCCTCGTCCAGGACCGAGTCCAAGGGTACTTTGC
GTCCTTTGCCAAAGCCTACGAAACGGTGTGTAAGCGCCAGGACAAGGAATTCTTCGGGCTTCGTGACTACTACAGCCTCATCAAAATGGT
CTTTGCTGCAGCAAAGGCTTCAAATAGAAAGCCTTCCCCGCAAGACATTGCACAGGCTGTCCTTAGGAACTTCAGTGGCAAGGATGACAT
CCAAGCTTTGGACATCTTTCTGGCCAATTTGCCCGAGGCCAAGTGCTCAGAGGAAGTCAGCCCCATGCAGCTGATCAAACAGAACATCTT
TGGGCCTTCTCAGAAGGTGCCGGGTGGAGAGCAGGAAGATGCTGAGTCCCGCTACTTACTCGTGCTGACCAAAAACTACGTGGCACTGCA
GATCCTGCAGCAGACATTCTTCGAGGGGGACCAGCAGCCGGAGATTATTTTTGGTTCTGGTTTCCCCAAGGACCAAGAGTACACCCAGCT
CTGCAGAAACATCAATCGTGTGAAGATCTGCATGGAAACAGGCAAGATGGTGTTGCTTCTCAACCTGCAGAACCTCTACGAGAGCCTCTA
CGACGCACTCAACCAGTACTACGTCCACCTCGGCGGCCAGAAGTACGTGGACCTCGGTCTGGGGACCCACCGCGTCAAATGTCGGGTTCA
CCCCAACTTCCGCCTGATTGTCATTGAAGAGAAAGACGTCGTGTACAAACACTTTCCCATCCCCCTCATTAACCGGCTGGAGAAGCACTA
TCTGGATATCAACACGGTGCTGGAGAAATGGCAGAAGAGCATCGTGGAGGAGCTCTGTGCGTGGGTGGAGAAGTTCATCAATGTCAAAGC
ACATCATTTCCAGAAGAGGCACAAATACAGCCCCTCTGACGTCTTCATCGGCTACCACTCGGACGCCTGCGCGTCTGTGGTGCTGCAGGT
CATAGAGAGGCAGGGTCCCCGGGCCTTGACGGAGGAACTTCACCAGAAGGTGTCTGAGGAGGCCAAATCGATCCTGCTGAACTGCGCTAC
GCCCGATGCCGTGGTCCGGCTGAGCGCCTACTCGCTGGGCGGGTTCGCAGCGGAGTGGCTGTCGCAGGAGTACTTTCACAGACAGAGGCA
CAACTCCTTTGCAGATTTCCTTCAGGCACACCTGCACACGGCAGACCTGGAGCGCCACGCCATCTTCACAGAGATCACCACTTTCTCCAG
GCTGCTAACAAGTCACGACTGTGAAATTTTAGAATCAGAGGTCACAGGCAGGGCTCCGAAACCCACACTCCTGTGGCTGCAGCAGTTTGA
CACCGAGTACTCATTCCTCAAAGAAGTCCGAAACTGTTTAACGAATACAGCCAAATGTAAAATCCTCATTTTTCAGACAGATTTTGAAGA
TGGAATCCGTAGCGCCCAGCTCATTGCCTCAGCTAAGTATTCTGTTATAAATGAAATCAACAAAATACGAGAAAATGAGGACCGTATCTT
CGTCTATTTCATCACAAAACTGTCCCGGGTGGGAAGAGGAACAGCCTATGTGGGCTTCCACGGAGGGCTGTGGCAGTCTGTCCACATCGA
TGACCTCCGGAGATCCACCCTCATGGTTTCTGATGTGACCAGGCTGCAGCATGTCACCATCAGCCAGCTGTTCGCGCCCGGAGACTTGCC
TGAGCTGGGCTTGGAACACCGGGCGGAAGACGGCCATGAGGAGGCGATGGAGACGGAGGCCAGCACATCAGGGGAGGTGGCAGAGGTGGC
AGAGGAGGCCATGGAAACAGAAAGTTCTGAGAAGGTGGGAAAGGAAACCTCTGAACTCGGAGGCAGTGATGTGTCGATCCTGGACACCAC
CAGGCTGCTGAGAAGCTGTGTGCAGAGCGCCGTGGGCATGCTCAGAGACCAGAACGAGAGCTGCACGCGCAATATGCGGAGGGTGGTGCT
CCTCCTGGGCCTCTTGAATGAGGATGACGCGTGCCACGCCTCTTTCTTGCGGGTATCCAAGATGCGCCTCAGTGTCTTTTTAAAGAAGCA
AGAAGAGAGCCAGTTTCACCCTCTGGAGTGGTTGGCAAGGGAAGCCTGCAACCAGGACGCTCTCCAGGAGGCGGGCACATTCAGGCACAC
CCTCTGGAAGCGGGTCCAAGGTGCTGTCACCCCTCTGCTGGCGAGCATGATATCATTCATCGACAGAGACGGCAACCTAGAGTTACTGAC
CAGGCCAGATACTCCGCCCTGGGCAAGAGATCTTTGGATGTTTATTTTCAGTGACACGATGCTTCTGAACATTCCTCTTGTGATGAATAA
TGAAAGACATAAAGGTGAGATGGCCTACATCGTGGTGCAGAACCACATGAACCTTTCCGAGAACGCTTCCAACAACGTCCCTTTCAGCTG
GAAAATCAAGGACTATCTGGAGGAGCTGTGGGTCCAGGCTCAGTACATCACAGACGCAGAAGGACTGCCCAAGAAGTTCGTGGACATCTT
TCAGCAGACTCCTCTGGGCAGGTTTCTTGCCCAGCTCCATGGAGAGCCGCAGCAGGAACTTCTTCAGTGTTACTTGAAGGATTTCATTCT
CTTGACCATGCGTGTGTCAACGGAGGAGGAATTAAAGTTTCTGCAGATGGCTCTGTGGTCCTGCACTAGGAAACTGAAAGCGGCGTCAGA
AGCGCCCGAGGAAGAGGTTTCCTTACCGTGGGTGCACCTTGCCTACCAGCGTTTCAGAAGCCGTCTGCAGAACTTTTCCAGAATCCTGAC
CATCTACCCTCAGGTTCTCCACAGCCTGATGGAAGCCCGTTGGAACCATGAGCTGGCTGGATGTGAGATGGCATGGAAAGCTCACCTGAT
GGGCCCAGCCGGCTGCACGATGAACCTGCGCAAGACACACATTCTGCAGAAGGCCCCGGCACTGCAGCCAGGGAAAAGCTCAGCTGTGGC
CGCATCAGGCCCCTTGGGGTCAAAGGCCGGAAGCAAGATCCCCACCCCGAAGGGCGGACTGAGCAAGAGCTCCAGCAGGACGTACGCCAA
GCGCTGACGCGGCGCTCGGGCTCCTTGGTCTCTGTGAGGGATGGAGCGGGTCTCCTGATTCTACACCATCTCTCCAGAACTCTCTGGCCT
TGGTGGCCCCATGCTCTGGCTGCTGTCCCCAGCTCCCCGCCGTGCACGCCTCTTACGCGTCTGTGCCGTCAGCTCTCGTGCAAACGATAT
GGATGCAGCTAACCAAAGATCCTGCGTGCAGTGCCAGGACCTGGCCGCACTGTACATTAAGCCTTCAGGGCTGTCTCAGGCCTTCCTTAG
AATCAGAGAAGGAAGCGTCCTGTTTGGAGAGAGCCAGAGAGCACCGCCGGGAGGCGCTCGCGCAAGGCCACGGTCAGCACAGGCACGGTC
CCGCTTTCCTTAGTGCTTGGAGCAATTTCCATAAAACATTCACCAGAAACCTTTTGCACATCGGTCTCTGCCACACGCAGTAGAATTTCC
GCAGGGCTGTGGCTCGGCCAGCAGCGGTTCCAGGAGAGTGGCGGTGCGCACGGGCCTCCAGCCGTGCCTTCCCCCTGCAGGCCCCGTCTG
CTGGGCCTGCTGCCCAGTGCACTCAGCCCCAGGTAGCAGAACTCACGTTCCCACTATAGCAAGAAATAAAGGCAAAAGAGAACATCTTTT
TTTTAATCGTAGTTTTTTTGAGAATTGGTCCCACCTCAGCCGCACCTTGCTGGATGCTTCTCCAGTAGTGCTGCCCCTGTGACAGGCATC
AGCTCCCTGCTGGAACTGAGGTAGACACAGGTGTGGGCCCTTCCCGTGCCTTTGCTCAGAGGCGCTTCACTTTCTCCACACTTTCGAATT
CCTAAAGACATGTGGAGGAAGTCACTGTTAAATGAATTTCCACCTGATCACCCTGTGTTCACAGCAGGCAGAAGCCCACTGGTATGGGCC
TCCCGCCCCTTCCACATCCATGTTGTGATTGGATCCATAAGTTTACTTTCTTCAAAGAGTTGATAGGATGTTTAAAACATCAACACATTG
CTTAAAATGATGAAACCAACCCTCAAAAAACAGTCTCCTAACCAGCCATCCCCTCCTGTGGGAGTGAGCTGGGGGTTTTGTCCATAGCTT
TGGTTGGGCCTGTGTCACATCCAGGCAGCCATGTGGAGGGAGTCAGGGTCTGTCTGGAAGCATCCACCCTCTCGCTGCCCCAGCCTGTGC
TCCCAGGGGCCTAGGCTACCATGGACTGAAGGGCAGTCCCCTCCCACCTGGTGCCCAGGGCTTCTGCTTGCCTCGCTGATGTTGCATGGG
CAGACTTCAAAAAGGATAGTTAGAAAGGTTTGGGTTGATGGAGTTTGCATTAATGCAATTAGTGTATAAATATGTTTTAATTGCCAACCG
TGTGAAACAACAAAATATCTAAAAACTAATCCCGATTTGAACAATGTACTCCCTGGCCTGGATACATTAATAACCATAAATTTGCATGAA
TTAATCTCCACGTTTGGTAAACTAATACCTCTGGTTGACTGAGAATACTGAGTAAGATATAAGACCTACCAGGAACCTTTAAGAATATGC
TCTGCTCAGTGTTGTTTGTCTGCTTGTTTGCGACGGAGTCTCACTGTGTCGCCCGGGCTGCAGTGCAATGGCGTGATCTTGGCTCACAGT
AACCTCCACCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCTAGTAGCTGGGATTACAGGTGCACACCACCATGCTCGGCTAATT
TTTTCTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCGTGACCTCATAATCTGCCCACCTTGGCCTCCC
AAAGTGCTGGGATTACAGGCGTGAGCCACCACGCCCAGGTTAAATGTGTTTATAAGGAGAGAGGAGGCCAGGCGCGGTGGCTCACGCTGT
AATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGACCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCCATCTC
TACTAAAAATACAAAAATGAGCCAGGCGTGGTGGCCTGTAGTCCCAGCTACTTGAGAGGCTGAGGCAGGAAAATTGCTTGAACCCGGGAG
GTGGAGGTTGCATTGAGCCCACATCATGCCATTGCACTCCAGCCCAGGCGACAGAGCGAGACTCCGTCTCGAAAAAAAAAAAAAGTATAA
GGAGAGAAATAACTTTAAAGTTTATTAGACAAAACAGAGTATAGATGCCAAGATGTCTGTAAAATGATTTTTTCTGGTTTTAAAGAGATG
TTGGCCATTATTTTCTAATCCATTTTTAAAATACAGACAAAACACTTCTTTAAACAGAACAAGAATGAGAAAAGTTAACCAAGGAATTAT
TCTTTTCTCACCAATCAACACTTTTAAGAAATATATATATATATATACACACATATACACATGCCTTCTATATATTGTAACTTAAAGAAA
ATACTTATAAAAAGACTTCATTTTTAGTGATTGACAAGCAAACGGGTTCATTTAAAACAGGTTCCTCTTTTGTTAGTTACAGGGGGTTTT
TTTGTTGTTTTTTTGTTTTTGTTTTTGTTTTGCGGGGGTGGTGGGGTTTGAGACGGAGTCTTGCTCTGTTGCCTAGGCTGGAGTGCAGTG
GCGCGATCTTGGCCCCCTGCAACCTCCGCCTCCCGGGTTCGAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCGTGT
GTCACCACGCCTGGCTAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATATTGGCCAGGCTGGTCTCAAACTCCTGACCTTGTG
ATCCACCCACCTCGGCCTCCCAAAGTGCTGGAATTACAGGCATGAGCCACCGCGCCCGGCCCAATCATGTGTTTTTGTTGAAATGATCCT
ACCAGTGATTAGTGGCTATTGAGAGTTTTACAGGGTTATACATTGTTAAGGGACCAAGAATCAAGTACAAAAAATTAAAAAGGAACTGTA
AAATCCCTTGGTCATTCATAAATAAATATCTAAATTAGGAATACTAATTAATTGAATTTTCACTCATGAGTATGTTCTGAATATTTAATA
TTTATTTCTATTATTTTCATATGTTAAGATATTCCATTAAATCTAACTTAAAAGAATTGTATGTATAAATTGGCATTAGGATACAAATGT
AAATGTTTTTAATGAAATTTTGCAACTTTTTAATATTTTAACATAGTTTTCTATTTGTCTTTATTTCAAGTACCAGAATTACAAAATATC

>74965_74965_2_RNF213-CEP104_RNF213_chr17_78337114_ENST00000508628_CEP104_chr1_3732934_ENST00000378230_length(amino acids)=3973AA_BP=3905
MECPSCQHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGGPCLFPGSDSWQENPEEPCSKASWTVQEGAT
SEVLVDAAVDLISDEWEAANAIPSKRRKQDAAPLEAASVPSADCEQSKKKKRKKKKKGNKSASSELASLPLSPASPCHLTLLSNPWPQDT
ALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALGEAGVATGSEAQSSPQFQDHTEGEDQDASIPSGGRGLSQEGT
GPPTSAGEGHSRTEDAAQELLLPESKGGSSEPGTELQTTEQQAGASASMAVDAVAEPANAVKGAGKEMKEKTQRMKQPPATTPPFKTHCQ
EAETKTKDEMAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKNQEADVQEVKASTLSPGGGVTVFFHAIISLHFPFNPDLHKVF
IRGGEEFGESKWDSNICELHYTRDLGHDRVLVEGIVCISKKHLDKYIPYKYVIYNGESFEYEFIYKHQQKKGEYVNRCLFIKSSLLGSGD
WHQYYDIVYMKPHGRLQKVMNHITDGPRKDLVKGKQIAAALMLDSTFSILQTWDTINLNSFFTQFEQFCFVLQQPMIYEGQAQLWTDLQY
REKEVKRYLWQHLKKHVVPLPDGKSTDFLPVDCPVRSKLKTGLIVLFVVEKIELLLEGSLDWLCHLLTSDASSPDEFHRDLSHILGIPQS
WRLYLVNLCQRCMDTRTYTWLGALPVLHCCMELAPRHKDAWRQPEDTWAALEGLSFSPFREQMLDTSSLLQFMREKQHLLSIDEPLFRSW
FSLLPLSHLVMYMENFIEHLGRFPAHILDCLSGIYYRLPGLEQVLNTQDVQDVQNVQNILEMLLRLLDTYRDKIPEEALSPSYLTVCLKL
HEAICSSTKLLKFYELPALSAEIVCRMIRLLSLVDSAGQRDETGNNSVQTVFQGTLAATKRWLREVFTKNMLTSSGASFTYVKEIEVWRR
LVEIQFPAEHGWKESLLGDMEWRLTKEEPLSQITAYCNSCWDTKGLEDSVAKTFEKCIIEAVSSACQSQTSILQGFSYSDLRKFGIVLSA
VITKSWPRTADNFNDILKHLLTLADVKHVFRLCGTDEKILANVTEDAKRLIAVADSVLTKVVGDLLSGTILVGQLELIIKHKNQFLDIWQ
LREKSLSPQDEQCAVEEALDWRREELLLLKKEKRCVDSLLKMCGNVKHLIQVDFGVLAVRHSQDLSSKRLNDTVTVRLSTSSNSQRATHY
HLSSQVQEMAGKIDLLRDSHIFQLFWREAAEPLSEPKEDQEAAELLSEPEEESERHILELEEVYDYLYQPSYRKFIKLHQDLKSGEVTLA
EIDVIFKDFVNKYTDLDSELKIMCTVDHQDQRDWIKDRVEQIKEYHHLHQAVHAAKVILQVKESLGLNGDFSVLNTLLNFTDNFDDFRRE
TLDQINQELIQAKKLLQDISEARCKGLQALSLRKEFICWVREALGGINELKVFVDLASISAGENDIDVDRVACFHDAVQGYASLLFKLDP
SVDFSAFMKHLKKLWKALDKDQYLPRKLCDSARNLEWLKTVNESHGSVERSSLTLATAINQRGIYVIQAPKGGQKISPDTVLHLILPESP
GSHEESREYSLEEVKELLNKLMLMSGKKDRNNTEVERFSEVFCSVQRLSQAFIDLHSAGNMLFRTWIAMAYCSPKQGVSLQMDFGLDLVT
ELKEGGDVTELLAALCRQMEHFLDSWKRFVTQKRMEHFYLNFYTAEQLVYLSTELRKQPPSDAALTMLSFIKSNCTLRDVLRASVGCGSE
AARYRMRRVMEELPLMLLSEFSLVDKLRIIMEQSMRCLPAFLPDCLDLETLGHCLAHLAGMGGSPVERCLPRGLQVGQPNLVVCGHSEVL
PAALAVYMQTPSQPLPTYDEVLLCTPATTFEEVALLLRRCLTLGSLGHKVYSLLFADQLSYEVARQAEELFHNLCTQQHREDYQLVMVCD
GDWEHCYLPSAFSQHKVFVTPQAPLEAIQAYLAGHYRVPKQTLSAAAVFNDRLCVGIVASERAGVGKSLYVKRLHDKMKMQLNVKNVPLK
TIRLIDPQVDESRVLGALLPFLDAQYQKVPVLFHLDVTSSVQTGIWVFLFKLLILQYLMDINGKMWLRNPCHLYIVEILERRTSVPSRSS
SALRTRVPQFSFLDIFPKVTCRPPKEVIDMELSALRSDTEPGMDLWEFCSETFQRPYQYLRRFNQNQDLDTFQYQEGSVEGTPEECLQHF
LFHCGVINPSWSELRNFARFLNYQLRDCEASLFCNPSFIGDTLRGFKKFVVTFMIFMARDFATPSLHTSDQSPGKHMVTMDGVREEDLAP
FSLRKRWESEPHPYVFFNDDHTTMTFIGFHLQPNINGSVDAISHLTGKVIKRDVMTRDLYQGLLLQRVPFNVDFDKLPRHKKLERLCLTL
GIPQATDPDKTYELTTDNMLKILAIEMRFRCGIPVIIMGETGCGKTRLIKFLSDLRRGGTNADTIKLVKVHGGTTADMIYSRVREAENVA
FANKDQHQLDTILFFDEANTTEAISCIKEVLCDHMVDGQPLAEDSGLHIIAACNPYRKHSEEMICRLESAGLGYRVSMEETADRLGSIPL
RQLVYRVHALPPSLIPLVWDFGQLSDVAEKLYIQQIVQRLVESISLDENGTRVITEVLCASQGFMRKTEDECSFVSLRDVERCVKVFRWF
HEHSAMLLAQLNAFLSKSSVSKNHTERDPVLWSLMLAIGVCYHASLEKKDSYRKAIARFFPKPYDDSRLLLDEITRAQDLFLDGVPLRKT
IAKNLALKENVFMMVVCIELKIPLFLVGKPGSSKSLAKTIVADAMQGPAAYSDLFRSLKQVHLVSFQCSPHSTPQGIISTFRQCARFQQG
KDLQQYVSVVVLDEVGLAEDSPKMPLKTLHPLLEDGCIEDDPAPHKKVGFVGISNWALDPAKMNRGIFVSRGSPNETELIESAKGICSSD
ILVQDRVQGYFASFAKAYETVCKRQDKEFFGLRDYYSLIKMVFAAAKASNRKPSPQDIAQAVLRNFSGKDDIQALDIFLANLPEAKCSEE
VSPMQLIKQNIFGPSQKVPGGEQEDAESRYLLVLTKNYVALQILQQTFFEGDQQPEIIFGSGFPKDQEYTQLCRNINRVKICMETGKMVL
LLNLQNLYESLYDALNQYYVHLGGQKYVDLGLGTHRVKCRVHPNFRLIVIEEKDVVYKHFPIPLINRLEKHYLDINTVLEKWQKSIVEEL
CAWVEKFINVKAHHFQKRHKYSPSDVFIGYHSDACASVVLQVIERQGPRALTEELHQKVSEEAKSILLNCATPDAVVRLSAYSLGGFAAE
WLSQEYFHRQRHNSFADFLQAHLHTADLERHAIFTEITTFSRLLTSHDCEILESEVTGRAPKPTLLWLQQFDTEYSFLKEVRNCLTNTAK
CKILIFQTDFEDGIRSAQLIASAKYSVINEINKIRENEDRIFVYFITKLSRVGRGTAYVGFHGGLWQSVHIDDLRRSTLMVSDVTRLQHV
TISQLFAPGDLPELGLEHRAEDGHEEAMETEASTSGEVAEVAEEAMETESSEKVGKETSELGGSDVSILDTTRLLRSCVQSAVGMLRDQN
ESCTRNMRRVVLLLGLLNEDDACHASFLRVSKMRLSVFLKKQEESQFHPLEWLAREACNQDALQEAGTFRHTLWKRVQGAVTPLLASMIS
FIDRDGNLELLTRPDTPPWARDLWMFIFSDTMLLNIPLVMNNERHKGEMAYIVVQNHMNLSENASNNVPFSWKIKDYLEELWVQAQYITD
AEGLPKKFVDIFQQTPLGRFLAQLHGEPQQELLQCYLKDFILLTMRVSTEEELKFLQMALWSCTRKLKAASEAPEEEVSLPWVHLAYQRF
RSRLQNFSRILTIYPQVLHSLMEARWNHELAGCEMAWKAHLMGPAGCTMNLRKTHILQKAPALQPGKSSAVAASGPLGSKAGSKIPTPKG

--------------------------------------------------------------
>74965_74965_3_RNF213-CEP104_RNF213_chr17_78337114_ENST00000582970_CEP104_chr1_3732934_ENST00000378230_length(transcript)=15239nt_BP=11711nt
CAGCGCGCGGCAGGCGGCGAGCTCGGGGGCCGCAGAAAATGAAACTGAAGCCGTGGTCACGTGACAGGACATGTAGTATATAGCAGGCTG
CCAGCGACTCCTGCTCTTGCTTCTGGATCTGCAGGGCAGTCCCAGCAGGACCCATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGAGG
AAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCCATAGCAGATTCTGAGAACAATAACTCCACAATGGCGT
CGGCCTCGGAGGGTGAAATGGAGTGTGGGCAGGAGCTGAAGGAGGAAGGGGGCCCGTGCTTGTTCCCGGGCTCAGACAGTTGGCAAGAAA
ACCCCGAGGAGCCCTGTTCCAAAGCCTCCTGGACCGTCCAAGAAAGCAAAAAGAAGAAAAGGAAGAAGAAAAAGAAGGGGAACAAGTCCG
CTTCCTCAGAGCTGGCTTCCTTGCCCCTTTCTCCTGCCAGCCCCTGTCACCTGACTTTGCTTTCAAACCCGTGGCCTCAGGACACAGCCC
TGCCCCACAGCCAAGCCCAGCAGAGTGGCCCCACTGGCCAGCCGAGCCAGCCCCCAGGCACAGCCACCACGCCACTGGAGGGTGACGGCC
TCTCCGCGCCCACCGAGGTTGGCGACAGCCCCCTGCAGGCCCAGGCTTTGGGAGAGGCAGGAGTGGCCACAGGAAGTGAGGCTCAGAGCA
GCCCGCAATTCCAGGACCACACGGAAGGGGAGGACCAGGACGCTTCCATCCCCTCTGGGGGCAGAGGCCTGTCCCAGGAGGGGACCGGTC
CCCCCACCTCTGCTGGTGAAGGCCATTCTAGGACTGAAGATGCTGCCCAGGAGCTCCTGTTGCCTGAGTCAAAAGGAGGCAGCTCTGAGC
CCGGGACAGAACTGCAGACCACCGAGCAACAGGCAGGGGCCTCAGCCTCTATGGCAGTTGATGCTGTAGCTGAGCCAGCCAATGCAGTTA
AAGGGGCCGGGAAGGAAATGAAAGAGAAGACCCAGAGAATGAAACAGCCACCAGCAACCACTCCTCCTTTCAAAACACACTGCCAGGAAG
CTGAGACCAAGACCAAGGACGAGATGGCTGCTGCTGAAGAAAAAGTCGGTAAGAATGAACAAGGGGAGCCTGAAGACCTCAAGAAGCCAG
AGGGGAAGAACAGAAGTGCAGCTGCTGTGAAAAACGAGAAGGAGCAAAAAAACCAGGAAGCAGATGTCCAGGAAGTGAAGGCAAGCACGC
TGAGCCCGGGTGGAGGAGTCACCGTGTTCTTCCACGCCATCATCTCTCTTCATTTCCCATTCAATCCTGACCTCCATAAAGTCTTCATCA
GAGGAGGAGAAGAATTTGGGGAGTCAAAATGGGACAGCAATATCTGTGAGCTGCACTACACCAGAGACTTGGGTCATGACCGCGTTCTTG
TTGAAGGCATTGTCTGCATTTCCAAGAAGCACCTAGATAAATACATTCCTTACAAGTACGTCATTTATAATGGGGAATCTTTTGAGTATG
AGTTCATTTACAAGCACCAGCAGAAGAAGGGCGAGTACGTCAACCGCTGTCTGTTCATAAAATCTTCACTTCTGGGCTCAGGAGACTGGC
ATCAGTACTATGACATAGTTTATATGAAGCCTCATGGGAGACTCCAGAAAGTCATGAACCACATCACAGACGGGCCGAGGAAGGACCTGG
TGAAGGGGAAGCAGATTGCCGCTGCGCTCATGCTGGACAGCACCTTCAGCATCCTGCAGACCTGGGACACCATCAACCTGAACAGCTTCT
TCACCCAGTTCGAGCAGTTTTGCTTTGTCCTGCAACAGCCTATGATTTATGAAGGACAGGCACAGCTGTGGACCGATTTGCAGTACAGGG
AGAAAGAGGTGAAGAGATACCTGTGGCAACATCTGAAAAAACACGTGGTACCATTGCCGGACGGAAAAAGCACGGACTTTTTGCCTGTGG
ACTGCCCAGTGAGGAGTAAACTGAAAACAGGCCTGATTGTCCTTTTTGTAGTGGAAAAAATTGAGCTTTTATTAGAAGGCAGCCTGGACT
GGTTGTGTCACCTCCTAACCTCAGATGCCAGCTCACCAGATGAGTTTCACCGTGACCTAAGCCACATCCTTGGGATACCTCAGAGCTGGC
GGCTGTACCTGGTGAACCTGTGCCAAAGATGCATGGACACAAGGACGTACACCTGGCTGGGCGCCCTGCCTGTCCTGCACTGCTGTATGG
AGCTGGCCCCGCGGCACAAGGATGCCTGGAGACAGCCTGAGGACACCTGGGCCGCTCTGGAGGGACTCTCCTTCTCACCGTTCCGGGAAC
AAATGCTAGATACGAGTTCCCTACTTCAGTTTATGAGAGAGAAGCAGCATTTGCTGAGCATAGACGAGCCTCTCTTCCGGTCCTGGTTTA
GTCTGCTACCTCTGAGTCACCTGGTTATGTATATGGAAAACTTCATTGAGCACCTGGGTCGTTTTCCTGCTCATATCCTGGACTGTCTTT
CAGGGATTTACTACCGGCTTCCGGGACTTGAGCAAGTCTTGAATACGCAGGATGTTCAGGATGTTCAGAACGTTCAGAACATTTTAGAAA
TGCTGTTGCGACTCCTGGACACTTACCGGGACAAGATTCCCGAGGAGGCCTTGTCACCATCCTACCTGACTGTGTGTCTGAAACTGCATG
AAGCCATCTGCAGCAGCACAAAGCTACTTAAGTTTTACGAGCTGCCAGCCTTATCTGCCGAGATTGTCTGCAGAATGATTAGACTTCTAT
CTCTGGTGGATTCTGCAGGACAGAGAGATGAAACTGGAAATAATTCAGTCCAAACAGTCTTCCAAGGGACCCTTGCTGCTACGAAAAGGT
GGCTCCGAGAAGTTTTTACAAAGAACATGCTCACATCTTCAGGTGCCTCATTCACATACGTCAAGGAAATTGAGGTCTGGAGGCGGCTGG
TGGAAATCCAATTCCCCGCGGAGCATGGCTGGAAGGAGTCGTTGCTGGGAGACATGGAATGGAGGCTCACAAAGGAGGAACCCCTCTCCC
AGATCACTGCCTACTGCAATAGTTGCTGGGACACCAAAGGCTTAGAGGACAGTGTGGCCAAGACCTTCGAGAAATGCATCATTGAAGCCG
TGAGCTCAGCCTGCCAGTCTCAGACCAGTATCCTTCAGGGGTTCTCTTACTCTGATTTGCGGAAATTTGGCATCGTCTTGTCTGCTGTGA
TCACTAAGTCCTGGCCTAGGACCGCGGACAACTTCAATGACATTTTAAAGCATCTGCTCACGTTGGCAGATGTCAAGCACGTCTTCAGAT
TGTGTGGAACCGACGAGAAAATACTAGCAAATGTCACAGAGGATGCCAAGAGGCTGATAGCTGTTGCCGACTCTGTGTTGACGAAAGTTG
TTGGTGACCTCCTAAGTGGCACGATTTTAGTTGGACAACTGGAGCTGATTATAAAGCACAAGAATCAGTTTCTTGACATCTGGCAACTGA
GGGAAAAAAGTCTTTCACCCCAGGATGAACAATGTGCTGTGGAGGAAGCACTGGATTGGAGAAGGGAGGAACTGTTACTTCTAAAGAAAG
AGAAAAGATGTGTTGATAGTCTCCTGAAGATGTGTGGGAACGTGAAACATCTGATACAAGTGGACTTTGGAGTGCTTGCAGTAAGACACT
CACAAGACCTCAGCAGTAAAAGATTAAATGACACCGTGACAGTGAGACTGTCCACCTCCTCGAACTCGCAGAGGGCAACGCATTACCACC
TGAGCTCCCAGGTCCAAGAAATGGCTGGGAAGATAGACTTGCTCAGAGACAGCCACATCTTCCAGCTCTTCTGGCGGGAAGCCGCAGAGC
CGCTGAGTGAGCCTAAGGAGGACCAGGAAGCCGCAGAGTTGCTGAGTGAGCCCGAAGAAGAATCAGAAAGGCACATCCTTGAGCTTGAAG
AGGTGTATGACTATTTGTATCAGCCTTCTTACAGAAAGTTCATTAAGTTGCACCAGGATCTAAAGTCAGGAGAGGTCACCCTTGCAGAGA
TTGATGTCATCTTCAAGGACTTTGTGAATAAATACACGGACCTGGATTCAGAACTTAAGATCATGTGCACCGTGGACCACCAGGACCAAA
GAGATTGGATCAAGGACCGAGTCGAACAGATCAAGGAATACCATCACCTGCACCAGGCTGTCCACGCAGCCAAGGTCATCTTGCAGGTCA
AAGAGAGCCTGGGACTGAACGGTGACTTCAGTGTTCTCAACACTTTACTAAATTTTACTGATAACTTCGACGACTTTCGCCGTGAAACAC
TGGACCAGATCAACCAGGAGCTCATCCAGGCCAAAAAGCTGCTCCAGGACATCAGCGAGGCCCGGTGCAAGGGGCTGCAGGCTCTGTCCC
TGAGAAAGGAGTTCATCTGCTGGGTCCGGGAGGCTCTTGGAGGCATCAATGAGCTGAAGGTGTTTGTGGACCTGGCCTCCATCTCAGCGG
GGGAGAATGACATTGATGTGGACCGGGTGGCCTGCTTCCATGACGCTGTGCAGGGCTACGCATCCCTGCTATTTAAGCTGGACCCCAGCG
TGGACTTCAGTGCATTCATGAAGCATCTGAAAAAGCTGTGGAAGGCTCTGGATAAGGACCAGTACCTGCCCAGGAAACTGTGTGACTCCG
CCAGGAACTTGGAATGGCTGAAGACTGTGAATGAGAGTCATGGGTCTGTGGAACGCTCATCCCTGACCCTGGCCACGGCCATCAACCAAA
GAGGCATCTATGTGATCCAGGCGCCCAAAGGTGGCCAAAAGATTTCCCCAGACACGGTTCTGCACTTGATCCTTCCTGAGAGCCCTGGCA
GCCACGAGGAGTCACGAGAGTACTCTTTAGAGGAGGTGAAGGAGCTTTTGAACAAGTTGATGCTGATGTCTGGCAAGAAGGATCGTAACA
ACACGGAAGTGGAGAGGTTTTCAGAGGTCTTCTGCAGTGTGCAGAGGCTCAGCCAGGCCTTCATCGACCTGCACTCTGCTGGGAATATGC
TGTTCAGGACGTGGATCGCCATGGCCTACTGCTCCCCCAAGCAGGGTGTGTCCCTCCAAATGGACTTTGGCTTGGACCTGGTGACGGAGC
TTAAAGAAGGTGGAGATGTCACTGAGCTGCTGGCAGCCCTCTGCAGGCAGATGGAGCACTTCCTTGACAGCTGGAAGAGATTTGTGACCC
AGAAGCGAATGGAGCACTTTTACCTGAACTTCTACACGGCAGAGCAGCTGGTTTACCTGAGCACTGAGCTCAGGAAGCAGCCCCCGAGTG
ATGCCGCCCTAACGATGCTATCCTTCATCAAAAGCAACTGCACCCTGAGGGATGTCTTAAGGGCCTCTGTGGGGTGTGGGAGTGAGGCCG
CCAGGTACCGCATGAGGAGAGTCATGGAAGAGCTCCCGCTGATGCTCTTATCAGAGTTCAGCCTGGTGGACAAGCTGAGGATCATCATGG
AGCAGTCCATGAGGTGCCTTCCTGCCTTCCTGCCCGACTGCCTCGACCTAGAGACCCTTGGCCACTGTCTGGCTCACCTGGCAGGGATGG
GTGGGTCTCCCGTGGAGCGTTGTCTCCCGAGAGGTCTGCAGGTCGGCCAGCCCAACCTCGTCGTCTGTGGCCACTCCGAGGTGTTGCCAG
CCGCCCTGGCTGTCTACATGCAAACCCCAAGCCAGCCCCTGCCCACTTACGATGAGGTGCTGCTCTGCACCCCGGCAACCACCTTTGAGG
AGGTGGCACTGTTGCTGCGCCGCTGCCTGACCCTGGGCTCCCTGGGGCACAAGGTCTACAGCCTGCTGTTCGCAGATCAGCTGAGCTACG
AGGTGGCACGCCAAGCGGAGGAGCTTTTCCACAATCTGTGCACGCAGCAGCACCGAGAAGACTACCAGCTCGTCATGGTCTGTGATGGGG
ACTGGGAGCACTGCTACCTCCCCTCTGCCTTCAGCCAGCACAAGGTCTTCGTCACCCCCCAGGCACCCCTCGAGGCCATCCAAGCCTACC
TGGCAGGTCACTACCGGGTCCCGAAGCAGACCCTGTCGGCGGCAGCCGTGTTCAATGACCGGCTGTGTGTTGGGATCGTGGCCTCGGAGC
GAGCAGGTGTTGGAAAGTCTCTGTACGTGAAGAGGTTGCACGACAAAATGAAGATGCAGTTAAACGTGAAAAATGTGCCTCTGAAAACAA
TTCGACTGATCGACCCTCAGGTGGATGAGAGCCGAGTCCTGGGCGCCCTGCTGCCCTTCCTGGATGCGCAGTATCAGAAGGTCCCCGTGC
TCTTTCACCTGGACGTGACCTCCTCAGTGCAGACTGGAATTTGGGTGTTTCTTTTCAAGCTCCTCATTTTACAATACTTAATGGATATAA
ATGGGAAAATGTGGCTTCGGAACCCCTGCCATTTGTATATCGTTGAAATCCTGGAAAGGAGGACGTCAGTGCCGTCGAGGAGCTCTTCAG
CGCTGCGTACACGTGTACCCCAGTTCAGTTTTCTTGACATCTTCCCAAAAGTCACCTGCAGGCCTCCCAAAGAGGTGATAGACATGGAGC
TGAGTGCCCTGAGGAGTGACACAGAGCCTGGGATGGATCTGTGGGAGTTCTGCAGCGAAACTTTCCAAAGACCTTACCAGTATTTAAGAC
GATTCAATCAAAACCAAGACCTAGACACGTTTCAGTATCAAGAAGGCTCTGTCGAAGGCACCCCGGAGGAATGCCTCCAGCATTTCCTGT
TTCACTGCGGGGTAATAAACCCATCCTGGTCAGAGCTTCGGAACTTTGCTCGGTTCCTGAATTATCAGCTCAGAGATTGTGAGGCCTCTC
TCTTCTGCAATCCGAGTTTTATTGGCGACACACTGAGGGGCTTCAAGAAGTTCGTGGTGACCTTCATGATCTTTATGGCAAGAGATTTTG
CCACACCATCACTCCACACCTCTGACCAAAGCCCGGGGAAGCACATGGTCACCATGGATGGGGTTAGGGAAGAAGATCTAGCGCCCTTCT
CCCTCCGGAAGAGGTGGGAGTCGGAGCCTCACCCATACGTTTTCTTCAATGACGACCACACAACCATGACATTCATCGGCTTCCATCTGC
AGCCCAACATCAACGGCAGTGTCGATGCCATCAGTCACTTGACTGGGAAGGTCATCAAGAGAGACGTCATGACCAGGGACCTGTACCAGG
GCCTGCTGCTCCAGAGGGTGCCCTTCAATGTCGACTTTGATAAACTGCCCAGACACAAGAAACTTGAGAGGCTCTGCCTGACCTTAGGGA
TCCCCCAGGCCACCGACCCCGACAAAACGTATGAGCTCACAACCGACAATATGCTTAAAATCCTTGCCATCGAGATGCGGTTCCGGTGTG
GGATCCCGGTTATCATCATGGGAGAAACTGGCTGTGGGAAAACCAGGCTTATTAAATTCCTTAGCGACCTGCGGCGTGGTGGTACCAATG
CTGACACCATAAAGCTGGTCAAGGTGCACGGAGGAACAACTGCAGACATGATCTACTCCAGAGTCAGGGAGGCTGAAAATGTGGCCTTCG
CCAATAAGGACCAACATCAGTTGGACACCATCTTGTTTTTTGATGAAGCCAACACAACGGAAGCTATAAGCTGTATCAAAGAAGTCCTGT
GTGATCATATGGTGGATGGCCAGCCTCTGGCTGAGGACTCTGGCCTGCATATTATAGCTGCCTGCAATCCATACCGGAAGCACTCTGAGG
AGATGATCTGCCGTTTGGAGTCAGCTGGTTTGGGCTACAGGGTTAGTATGGAGGAGACGGCCGACAGGCTGGGCTCCATTCCTCTGAGGC
AGCTGGTATACCGGGTCCATGCTCTGCCCCCGAGCCTGATTCCTCTGGTGTGGGACTTTGGACAACTGAGTGACGTTGCTGAAAAGCTCT
ACATCCAGCAGATTGTCCAGAGACTGGTTGAGTCCATCAGCCTAGATGAAAACGGGACTCGCGTGATCACAGAAGTCCTCTGCGCCTCTC
AGGGTTTCATGAGGAAAACAGAAGATGAGTGCAGCTTTGTCAGCCTCAGGGACGTGGAGCGCTGTGTGAAAGTTTTCAGGTGGTTCCACG
AGCACAGCGCGATGCTCTTAGCGCAGCTGAATGCCTTTCTCTCCAAGTCCAGCGTCAGCAAAAATCACACCGAGAGAGATCCCGTCCTCT
GGTCGTTGATGCTGGCCATCGGGGTGTGTTACCATGCCTCTTTAGAAAAGAAAGACTCATATCGGAAAGCCATCGCCAGGTTCTTTCCGA
AACCGTATGACGACAGCAGGCTGCTTCTGGATGAAATAACACGGGCACAGGATCTTTTTCTGGACGGCGTACCTCTGAGGAAAACCATCG
CCAAGAACTTGGCCTTGAAGGAGAACGTCTTCATGATGGTCGTCTGCATCGAGCTGAAGATTCCCCTCTTCCTGGTGGGGAAGCCCGGCA
GCTCCAAGTCTCTCGCCAAGACCATCGTGGCAGACGCCATGCAGGGCCCGGCTGCCTACTCAGATCTCTTCCGCAGCCTGAAGCAGGTCC
ACCTGGTGTCCTTCCAGTGCAGCCCGCACTCCACCCCACAGGGCATCATCAGCACCTTCCGGCAGTGCGCCCGCTTTCAGCAGGGGAAGG
ACCTGCAGCAGTACGTCTCTGTGGTGGTGTTAGATGAGGTGGGGCTGGCGGAAGACTCACCCAAAATGCCCCTGAAGACTCTGCACCCGC
TGCTGGAAGACGGATGCATTGAAGACGATCCCGCCCCCCACAAAAAGGTCGGCTTCGTGGGCATCTCCAACTGGGCCCTTGACCCTGCCA
AGATGAACCGGGGCATTTTTGTGTCACGTGGCAGCCCCAACGAGACAGAGCTCATAGAGAGCGCCAAGGGCATCTGCTCCTCAGACATCC
TCGTCCAGGACCGAGTCCAAGGGTACTTTGCGTCCTTTGCCAAAGCCTACGAAACGGTGTGTAAGCGCCAGGACAAGGAATTCTTCGGGC
TTCGTGACTACTACAGCCTCATCAAAATGGTCTTTGCTGCAGCAAAGGCTTCAAATAGAAAGCCTTCCCCGCAAGACATTGCACAGGCTG
TCCTTAGGAACTTCAGTGGCAAGGATGACATCCAAGCTTTGGACATCTTTCTGGCCAATTTGCCCGAGGCCAAGTGCTCAGAGGAAGTCA
GCCCCATGCAGCTGATCAAACAGAACATCTTTGGGCCTTCTCAGAAGGTGCCGGGTGGAGAGCAGGAAGATGCTGAGTCCCGCTACTTAC
TCGTGCTGACCAAAAACTACGTGGCACTGCAGATCCTGCAGCAGACATTCTTCGAGGGGGACCAGCAGCCGGAGATTATTTTTGGTTCTG
GTTTCCCCAAGGACCAAGAGTACACCCAGCTCTGCAGAAACATCAATCGTGTGAAGATCTGCATGGAAACAGGCAAGATGGTGTTGCTTC
TCAACCTGCAGAACCTCTACGAGAGCCTCTACGACGCACTCAACCAGTACTACGTCCACCTCGGCGGCCAGAAGTACGTGGACCTCGGTC
TGGGGACCCACCGCGTCAAATGTCGGGTTCACCCCAACTTCCGCCTGATTGTCATTGAAGAGAAAGACGTCGTGTACAAACACTTTCCCA
TCCCCCTCATTAACCGGCTGGAGAAGCACTATCTGGATATCAACACGGTGCTGGAGAAATGGCAGAAGAGCATCGTGGAGGAGCTCTGTG
CGTGGGTGGAGAAGTTCATCAATGTCAAAGCACATCATTTCCAGAAGAGGCACAAATACAGCCCCTCTGACGTCTTCATCGGCTACCACT
CGGACGCCTGCGCGTCTGTGGTGCTGCAGGTCATAGAGAGGCAGGGTCCCCGGGCCTTGACGGAGGAACTTCACCAGAAGGTGTCTGAGG
AGGCCAAATCGATCCTGCTGAACTGCGCTACGCCCGATGCCGTGGTCCGGCTGAGCGCCTACTCGCTGGGCGGGTTCGCAGCGGAGTGGC
TGTCGCAGGAGTACTTTCACAGACAGAGGCACAACTCCTTTGCAGATTTCCTTCAGGCACACCTGCACACGGCAGACCTGGAGCGCCACG
CCATCTTCACAGAGATCACCACTTTCTCCAGGCTGCTAACAAGTCACGACTGTGAAATTTTAGAATCAGAGGTCACAGGCAGGGCTCCGA
AACCCACACTCCTGTGGCTGCAGCAGTTTGACACCGAGTACTCATTCCTCAAAGAAGTCCGAAACTGTTTAACGAATACAGCCAAATGTA
AAATCCTCATTTTTCAGACAGATTTTGAAGATGGAATCCGTAGCGCCCAGCTCATTGCCTCAGCTAAGTATTCTGTTATAAATGAAATCA
ACAAAATACGAGAAAATGAGGACCGTATCTTCGTCTATTTCATCACAAAACTGTCCCGGGTGGGAAGAGGAACAGCCTATGTGGGCTTCC
ACGGAGGGCTGTGGCAGTCTGTCCACATCGATGACCTCCGGAGATCCACCCTCATGGTTTCTGATGTGACCAGGCTGCAGCATGTCACCA
TCAGCCAGCTGTTCGCGCCCGGAGACTTGCCTGAGCTGGGCTTGGAACACCGGGCGGAAGACGGCCATGAGGAGGCGATGGAGACGGAGG
CCAGCACATCAGGGGAGGTGGCAGAGGTGGCAGAGGAGGCCATGGAAACAGAAAGTTCTGAGAAGGTGGGAAAGGAAACCTCTGAACTCG
GAGGCAGTGATGTGTCGATCCTGGACACCACCAGGCTGCTGAGAAGCTGTGTGCAGAGCGCCGTGGGCATGCTCAGAGACCAGAACGAGA
GCTGCACGCGCAATATGCGGAGGGTGGTGCTCCTCCTGGGCCTCTTGAATGAGGATGACGCGTGCCACGCCTCTTTCTTGCGGGTATCCA
AGATGCGCCTCAGTGTCTTTTTAAAGAAGCAAGAAGAGAGCCAGTTTCACCCTCTGGAGTGGTTGGCAAGGGAAGCCTGCAACCAGGACG
CTCTCCAGGAGGCGGGCACATTCAGGCACACCCTCTGGAAGCGGGTCCAAGGTGCTGTCACCCCTCTGCTGGCGAGCATGATATCATTCA
TCGACAGAGACGGCAACCTAGAGTTACTGACCAGGCCAGATACTCCGCCCTGGGCAAGAGATCTTTGGATGTTTATTTTCAGTGACACGA
TGCTTCTGAACATTCCTCTTGTGATGAATAATGAAAGACATAAAGGTGAGATGGCCTACATCGTGGTGCAGAACCACATGAACCTTTCCG
AGAACGCTTCCAACAACGTCCCTTTCAGCTGGAAAATCAAGGACTATCTGGAGGAGCTGTGGGTCCAGGCTCAGTACATCACAGACGCAG
AAGGACTGCCCAAGAAGTTCGTGGACATCTTTCAGCAGACTCCTCTGGGCAGGTTTCTTGCCCAGCTCCATGGAGAGCCGCAGCAGGAAC
TTCTTCAGTGTTACTTGAAGGATTTCATTCTCTTGACCATGCGTGTGTCAACGGAGGAGGAATTAAAGTTTCTGCAGATGGCTCTGTGGT
CCTGCACTAGGAAACTGAAAGCGGCGTCAGAAGCGCCCGAGGAAGAGGTTTCCTTACCGTGGGTGCACCTTGCCTACCAGCGTTTCAGAA
GCCGTCTGCAGAACTTTTCCAGAATCCTGACCATCTACCCTCAGGTTCTCCACAGCCTGATGGAAGCCCGTTGGAACCATGAGCTGGCTG
GATGTGAGATGGCATGGAAAGCTCACCTGATGGGCCCAGCCGGCTGCACGATGAACCTGCGCAAGACACACATTCTGCAGAAGGCCCCGG
CACTGCAGCCAGGGAAAAGCTCAGCTGTGGCCGCATCAGGCCCCTTGGGGTCAAAGGCCGGAAGCAAGATCCCCACCCCGAAGGGCGGAC
TGAGCAAGAGCTCCAGCAGGACGTACGCCAAGCGCTGACGCGGCGCTCGGGCTCCTTGGTCTCTGTGAGGGATGGAGCGGGTCTCCTGAT
TCTACACCATCTCTCCAGAACTCTCTGGCCTTGGTGGCCCCATGCTCTGGCTGCTGTCCCCAGCTCCCCGCCGTGCACGCCTCTTACGCG
TCTGTGCCGTCAGCTCTCGTGCAAACGATATGGATGCAGCTAACCAAAGATCCTGCGTGCAGTGCCAGGACCTGGCCGCACTGTACATTA
AGCCTTCAGGGCTGTCTCAGGCCTTCCTTAGAATCAGAGAAGGAAGCGTCCTGTTTGGAGAGAGCCAGAGAGCACCGCCGGGAGGCGCTC
GCGCAAGGCCACGGTCAGCACAGGCACGGTCCCGCTTTCCTTAGTGCTTGGAGCAATTTCCATAAAACATTCACCAGAAACCTTTTGCAC
ATCGGTCTCTGCCACACGCAGTAGAATTTCCGCAGGGCTGTGGCTCGGCCAGCAGCGGTTCCAGGAGAGTGGCGGTGCGCACGGGCCTCC
AGCCGTGCCTTCCCCCTGCAGGCCCCGTCTGCTGGGCCTGCTGCCCAGTGCACTCAGCCCCAGGTAGCAGAACTCACGTTCCCACTATAG
CAAGAAATAAAGGCAAAAGAGAACATCTTTTTTTTAATCGTAGTTTTTTTGAGAATTGGTCCCACCTCAGCCGCACCTTGCTGGATGCTT
CTCCAGTAGTGCTGCCCCTGTGACAGGCATCAGCTCCCTGCTGGAACTGAGGTAGACACAGGTGTGGGCCCTTCCCGTGCCTTTGCTCAG
AGGCGCTTCACTTTCTCCACACTTTCGAATTCCTAAAGACATGTGGAGGAAGTCACTGTTAAATGAATTTCCACCTGATCACCCTGTGTT
CACAGCAGGCAGAAGCCCACTGGTATGGGCCTCCCGCCCCTTCCACATCCATGTTGTGATTGGATCCATAAGTTTACTTTCTTCAAAGAG
TTGATAGGATGTTTAAAACATCAACACATTGCTTAAAATGATGAAACCAACCCTCAAAAAACAGTCTCCTAACCAGCCATCCCCTCCTGT
GGGAGTGAGCTGGGGGTTTTGTCCATAGCTTTGGTTGGGCCTGTGTCACATCCAGGCAGCCATGTGGAGGGAGTCAGGGTCTGTCTGGAA
GCATCCACCCTCTCGCTGCCCCAGCCTGTGCTCCCAGGGGCCTAGGCTACCATGGACTGAAGGGCAGTCCCCTCCCACCTGGTGCCCAGG
GCTTCTGCTTGCCTCGCTGATGTTGCATGGGCAGACTTCAAAAAGGATAGTTAGAAAGGTTTGGGTTGATGGAGTTTGCATTAATGCAAT
TAGTGTATAAATATGTTTTAATTGCCAACCGTGTGAAACAACAAAATATCTAAAAACTAATCCCGATTTGAACAATGTACTCCCTGGCCT
GGATACATTAATAACCATAAATTTGCATGAATTAATCTCCACGTTTGGTAAACTAATACCTCTGGTTGACTGAGAATACTGAGTAAGATA
TAAGACCTACCAGGAACCTTTAAGAATATGCTCTGCTCAGTGTTGTTTGTCTGCTTGTTTGCGACGGAGTCTCACTGTGTCGCCCGGGCT
GCAGTGCAATGGCGTGATCTTGGCTCACAGTAACCTCCACCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCTAGTAGCTGGGAT
TACAGGTGCACACCACCATGCTCGGCTAATTTTTTCTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCG
TGACCTCATAATCTGCCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCACGCCCAGGTTAAATGTGTTTATAAGGAG
AGAGGAGGCCAGGCGCGGTGGCTCACGCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGACCACCTGAGGTCAGGAGTTCGAGAC
CAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATGAGCCAGGCGTGGTGGCCTGTAGTCCCAGCTACTTGAGAGG
CTGAGGCAGGAAAATTGCTTGAACCCGGGAGGTGGAGGTTGCATTGAGCCCACATCATGCCATTGCACTCCAGCCCAGGCGACAGAGCGA
GACTCCGTCTCGAAAAAAAAAAAAAGTATAAGGAGAGAAATAACTTTAAAGTTTATTAGACAAAACAGAGTATAGATGCCAAGATGTCTG
TAAAATGATTTTTTCTGGTTTTAAAGAGATGTTGGCCATTATTTTCTAATCCATTTTTAAAATACAGACAAAACACTTCTTTAAACAGAA
CAAGAATGAGAAAAGTTAACCAAGGAATTATTCTTTTCTCACCAATCAACACTTTTAAGAAATATATATATATATATACACACATATACA
CATGCCTTCTATATATTGTAACTTAAAGAAAATACTTATAAAAAGACTTCATTTTTAGTGATTGACAAGCAAACGGGTTCATTTAAAACA
GGTTCCTCTTTTGTTAGTTACAGGGGGTTTTTTTGTTGTTTTTTTGTTTTTGTTTTTGTTTTGCGGGGGTGGTGGGGTTTGAGACGGAGT
CTTGCTCTGTTGCCTAGGCTGGAGTGCAGTGGCGCGATCTTGGCCCCCTGCAACCTCCGCCTCCCGGGTTCGAGCAATTCTCCTGCCTCA
GCCTCCCGAGTAGCTGGGATTACAGGCGTGTGTCACCACGCCTGGCTAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATATTG
GCCAGGCTGGTCTCAAACTCCTGACCTTGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGAATTACAGGCATGAGCCACCGCGCCCGG
CCCAATCATGTGTTTTTGTTGAAATGATCCTACCAGTGATTAGTGGCTATTGAGAGTTTTACAGGGTTATACATTGTTAAGGGACCAAGA
ATCAAGTACAAAAAATTAAAAAGGAACTGTAAAATCCCTTGGTCATTCATAAATAAATATCTAAATTAGGAATACTAATTAATTGAATTT
TCACTCATGAGTATGTTCTGAATATTTAATATTTATTTCTATTATTTTCATATGTTAAGATATTCCATTAAATCTAACTTAAAAGAATTG
TATGTATAAATTGGCATTAGGATACAAATGTAAATGTTTTTAATGAAATTTTGCAACTTTTTAATATTTTAACATAGTTTTCTATTTGTC
TTTATTTCAAGTACCAGAATTACAAAATATCTAAGTAATATATTTTTGTTGTCGTTTTAGGGCTTAAGGGTTAATTCACCCAGAGTATAT

>74965_74965_3_RNF213-CEP104_RNF213_chr17_78337114_ENST00000582970_CEP104_chr1_3732934_ENST00000378230_length(amino acids)=3924AA_BP=3856
MECPSCQHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGGPCLFPGSDSWQENPEEPCSKASWTVQESKK
KKRKKKKKGNKSASSELASLPLSPASPCHLTLLSNPWPQDTALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALG
EAGVATGSEAQSSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQELLLPESKGGSSEPGTELQTTEQQAGASASM
AVDAVAEPANAVKGAGKEMKEKTQRMKQPPATTPPFKTHCQEAETKTKDEMAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKN
QEADVQEVKASTLSPGGGVTVFFHAIISLHFPFNPDLHKVFIRGGEEFGESKWDSNICELHYTRDLGHDRVLVEGIVCISKKHLDKYIPY
KYVIYNGESFEYEFIYKHQQKKGEYVNRCLFIKSSLLGSGDWHQYYDIVYMKPHGRLQKVMNHITDGPRKDLVKGKQIAAALMLDSTFSI
LQTWDTINLNSFFTQFEQFCFVLQQPMIYEGQAQLWTDLQYREKEVKRYLWQHLKKHVVPLPDGKSTDFLPVDCPVRSKLKTGLIVLFVV
EKIELLLEGSLDWLCHLLTSDASSPDEFHRDLSHILGIPQSWRLYLVNLCQRCMDTRTYTWLGALPVLHCCMELAPRHKDAWRQPEDTWA
ALEGLSFSPFREQMLDTSSLLQFMREKQHLLSIDEPLFRSWFSLLPLSHLVMYMENFIEHLGRFPAHILDCLSGIYYRLPGLEQVLNTQD
VQDVQNVQNILEMLLRLLDTYRDKIPEEALSPSYLTVCLKLHEAICSSTKLLKFYELPALSAEIVCRMIRLLSLVDSAGQRDETGNNSVQ
TVFQGTLAATKRWLREVFTKNMLTSSGASFTYVKEIEVWRRLVEIQFPAEHGWKESLLGDMEWRLTKEEPLSQITAYCNSCWDTKGLEDS
VAKTFEKCIIEAVSSACQSQTSILQGFSYSDLRKFGIVLSAVITKSWPRTADNFNDILKHLLTLADVKHVFRLCGTDEKILANVTEDAKR
LIAVADSVLTKVVGDLLSGTILVGQLELIIKHKNQFLDIWQLREKSLSPQDEQCAVEEALDWRREELLLLKKEKRCVDSLLKMCGNVKHL
IQVDFGVLAVRHSQDLSSKRLNDTVTVRLSTSSNSQRATHYHLSSQVQEMAGKIDLLRDSHIFQLFWREAAEPLSEPKEDQEAAELLSEP
EEESERHILELEEVYDYLYQPSYRKFIKLHQDLKSGEVTLAEIDVIFKDFVNKYTDLDSELKIMCTVDHQDQRDWIKDRVEQIKEYHHLH
QAVHAAKVILQVKESLGLNGDFSVLNTLLNFTDNFDDFRRETLDQINQELIQAKKLLQDISEARCKGLQALSLRKEFICWVREALGGINE
LKVFVDLASISAGENDIDVDRVACFHDAVQGYASLLFKLDPSVDFSAFMKHLKKLWKALDKDQYLPRKLCDSARNLEWLKTVNESHGSVE
RSSLTLATAINQRGIYVIQAPKGGQKISPDTVLHLILPESPGSHEESREYSLEEVKELLNKLMLMSGKKDRNNTEVERFSEVFCSVQRLS
QAFIDLHSAGNMLFRTWIAMAYCSPKQGVSLQMDFGLDLVTELKEGGDVTELLAALCRQMEHFLDSWKRFVTQKRMEHFYLNFYTAEQLV
YLSTELRKQPPSDAALTMLSFIKSNCTLRDVLRASVGCGSEAARYRMRRVMEELPLMLLSEFSLVDKLRIIMEQSMRCLPAFLPDCLDLE
TLGHCLAHLAGMGGSPVERCLPRGLQVGQPNLVVCGHSEVLPAALAVYMQTPSQPLPTYDEVLLCTPATTFEEVALLLRRCLTLGSLGHK
VYSLLFADQLSYEVARQAEELFHNLCTQQHREDYQLVMVCDGDWEHCYLPSAFSQHKVFVTPQAPLEAIQAYLAGHYRVPKQTLSAAAVF
NDRLCVGIVASERAGVGKSLYVKRLHDKMKMQLNVKNVPLKTIRLIDPQVDESRVLGALLPFLDAQYQKVPVLFHLDVTSSVQTGIWVFL
FKLLILQYLMDINGKMWLRNPCHLYIVEILERRTSVPSRSSSALRTRVPQFSFLDIFPKVTCRPPKEVIDMELSALRSDTEPGMDLWEFC
SETFQRPYQYLRRFNQNQDLDTFQYQEGSVEGTPEECLQHFLFHCGVINPSWSELRNFARFLNYQLRDCEASLFCNPSFIGDTLRGFKKF
VVTFMIFMARDFATPSLHTSDQSPGKHMVTMDGVREEDLAPFSLRKRWESEPHPYVFFNDDHTTMTFIGFHLQPNINGSVDAISHLTGKV
IKRDVMTRDLYQGLLLQRVPFNVDFDKLPRHKKLERLCLTLGIPQATDPDKTYELTTDNMLKILAIEMRFRCGIPVIIMGETGCGKTRLI
KFLSDLRRGGTNADTIKLVKVHGGTTADMIYSRVREAENVAFANKDQHQLDTILFFDEANTTEAISCIKEVLCDHMVDGQPLAEDSGLHI
IAACNPYRKHSEEMICRLESAGLGYRVSMEETADRLGSIPLRQLVYRVHALPPSLIPLVWDFGQLSDVAEKLYIQQIVQRLVESISLDEN
GTRVITEVLCASQGFMRKTEDECSFVSLRDVERCVKVFRWFHEHSAMLLAQLNAFLSKSSVSKNHTERDPVLWSLMLAIGVCYHASLEKK
DSYRKAIARFFPKPYDDSRLLLDEITRAQDLFLDGVPLRKTIAKNLALKENVFMMVVCIELKIPLFLVGKPGSSKSLAKTIVADAMQGPA
AYSDLFRSLKQVHLVSFQCSPHSTPQGIISTFRQCARFQQGKDLQQYVSVVVLDEVGLAEDSPKMPLKTLHPLLEDGCIEDDPAPHKKVG
FVGISNWALDPAKMNRGIFVSRGSPNETELIESAKGICSSDILVQDRVQGYFASFAKAYETVCKRQDKEFFGLRDYYSLIKMVFAAAKAS
NRKPSPQDIAQAVLRNFSGKDDIQALDIFLANLPEAKCSEEVSPMQLIKQNIFGPSQKVPGGEQEDAESRYLLVLTKNYVALQILQQTFF
EGDQQPEIIFGSGFPKDQEYTQLCRNINRVKICMETGKMVLLLNLQNLYESLYDALNQYYVHLGGQKYVDLGLGTHRVKCRVHPNFRLIV
IEEKDVVYKHFPIPLINRLEKHYLDINTVLEKWQKSIVEELCAWVEKFINVKAHHFQKRHKYSPSDVFIGYHSDACASVVLQVIERQGPR
ALTEELHQKVSEEAKSILLNCATPDAVVRLSAYSLGGFAAEWLSQEYFHRQRHNSFADFLQAHLHTADLERHAIFTEITTFSRLLTSHDC
EILESEVTGRAPKPTLLWLQQFDTEYSFLKEVRNCLTNTAKCKILIFQTDFEDGIRSAQLIASAKYSVINEINKIRENEDRIFVYFITKL
SRVGRGTAYVGFHGGLWQSVHIDDLRRSTLMVSDVTRLQHVTISQLFAPGDLPELGLEHRAEDGHEEAMETEASTSGEVAEVAEEAMETE
SSEKVGKETSELGGSDVSILDTTRLLRSCVQSAVGMLRDQNESCTRNMRRVVLLLGLLNEDDACHASFLRVSKMRLSVFLKKQEESQFHP
LEWLAREACNQDALQEAGTFRHTLWKRVQGAVTPLLASMISFIDRDGNLELLTRPDTPPWARDLWMFIFSDTMLLNIPLVMNNERHKGEM
AYIVVQNHMNLSENASNNVPFSWKIKDYLEELWVQAQYITDAEGLPKKFVDIFQQTPLGRFLAQLHGEPQQELLQCYLKDFILLTMRVST
EEELKFLQMALWSCTRKLKAASEAPEEEVSLPWVHLAYQRFRSRLQNFSRILTIYPQVLHSLMEARWNHELAGCEMAWKAHLMGPAGCTM

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for RNF213-CEP104


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for RNF213-CEP104


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for RNF213-CEP104


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource