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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RNF213-HSD17B14 (FusionGDB2 ID:74974)

Fusion Gene Summary for RNF213-HSD17B14

check button Fusion gene summary
Fusion gene informationFusion gene name: RNF213-HSD17B14
Fusion gene ID: 74974
HgeneTgene
Gene symbol

RNF213

HSD17B14

Gene ID

57674

51171

Gene namering finger protein 213hydroxysteroid 17-beta dehydrogenase 14
SynonymsALO17|C17orf27|KIAA1618|MYMY2|MYSTR|NET57DHRS10|SDR47C1|retSDR3
Cytomap

17q25.3

19q13.33

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase RNF213ALK lymphoma oligomerization partner on chromosome 17RING-type E3 ubiquitin transferase RNF213mysterin17-beta-hydroxysteroid dehydrogenase 1417-beta-HSD 1417-beta-hydroxysteroid dehydrogenase DHRS10dehydrogenase/reductase (SDR family) member 10retinal short-chain dehydrogenase/reductase 3retinal short-chain dehydrogenase/reductase retSDR3short chain
Modification date2020031320200327
UniProtAcc.

Q9BPX1

Ensembl transtripts involved in fusion geneENST00000319921, ENST00000456466, 
ENST00000508628, ENST00000582970, 
ENST00000336301, ENST00000427003, 
ENST00000263278, ENST00000599157, 
Fusion gene scores* DoF score34 X 32 X 16=1740810 X 3 X 7=210
# samples 419
** MAII scorelog2(41/17408*10)=-5.40798274174489
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/210*10)=-1.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RNF213 [Title/Abstract] AND HSD17B14 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRNF213(78286967)-HSD17B14(49318398), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRNF213

GO:0016567

protein ubiquitination

21799892

HgeneRNF213

GO:0051260

protein homooligomerization

24658080|26126547

HgeneRNF213

GO:0051865

protein autoubiquitination

21799892

TgeneHSD17B14

GO:0006706

steroid catabolic process

17067289


check buttonFusion gene breakpoints across RNF213 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HSD17B14 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-DD-A11C-01ARNF213chr17

78286967

+HSD17B14chr19

49318398

-


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Fusion Gene ORF analysis for RNF213-HSD17B14

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000319921ENST00000263278RNF213chr17

78286967

+HSD17B14chr19

49318398

-
In-frameENST00000319921ENST00000599157RNF213chr17

78286967

+HSD17B14chr19

49318398

-
In-frameENST00000456466ENST00000263278RNF213chr17

78286967

+HSD17B14chr19

49318398

-
In-frameENST00000456466ENST00000599157RNF213chr17

78286967

+HSD17B14chr19

49318398

-
In-frameENST00000508628ENST00000263278RNF213chr17

78286967

+HSD17B14chr19

49318398

-
In-frameENST00000508628ENST00000599157RNF213chr17

78286967

+HSD17B14chr19

49318398

-
In-frameENST00000582970ENST00000263278RNF213chr17

78286967

+HSD17B14chr19

49318398

-
In-frameENST00000582970ENST00000599157RNF213chr17

78286967

+HSD17B14chr19

49318398

-
intron-3CDSENST00000336301ENST00000263278RNF213chr17

78286967

+HSD17B14chr19

49318398

-
intron-3CDSENST00000336301ENST00000599157RNF213chr17

78286967

+HSD17B14chr19

49318398

-
intron-3CDSENST00000427003ENST00000263278RNF213chr17

78286967

+HSD17B14chr19

49318398

-
intron-3CDSENST00000427003ENST00000599157RNF213chr17

78286967

+HSD17B14chr19

49318398

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000508628RNF213chr1778286967+ENST00000263278HSD17B14chr1949318398-3705310314535461133
ENST00000508628RNF213chr1778286967+ENST00000599157HSD17B14chr1949318398-3698310314535461133
ENST00000456466RNF213chr1778286967+ENST00000263278HSD17B14chr1949318398-3556295414333971084
ENST00000456466RNF213chr1778286967+ENST00000599157HSD17B14chr1949318398-3549295414333971084
ENST00000582970RNF213chr1778286967+ENST00000263278HSD17B14chr1949318398-3556295414333971084
ENST00000582970RNF213chr1778286967+ENST00000599157HSD17B14chr1949318398-3549295414333971084
ENST00000319921RNF213chr1778286967+ENST00000263278HSD17B14chr1949318398-3554295214133951084
ENST00000319921RNF213chr1778286967+ENST00000599157HSD17B14chr1949318398-3547295214133951084

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000508628ENST00000263278RNF213chr1778286967+HSD17B14chr1949318398-0.0028623420.99713767
ENST00000508628ENST00000599157RNF213chr1778286967+HSD17B14chr1949318398-0.0028018280.9971982
ENST00000456466ENST00000263278RNF213chr1778286967+HSD17B14chr1949318398-0.0023831250.9976169
ENST00000456466ENST00000599157RNF213chr1778286967+HSD17B14chr1949318398-0.0023328570.9976672
ENST00000582970ENST00000263278RNF213chr1778286967+HSD17B14chr1949318398-0.0023831250.9976169
ENST00000582970ENST00000599157RNF213chr1778286967+HSD17B14chr1949318398-0.0023328570.9976672
ENST00000319921ENST00000263278RNF213chr1778286967+HSD17B14chr1949318398-0.0023822130.9976178
ENST00000319921ENST00000599157RNF213chr1778286967+HSD17B14chr1949318398-0.0023319310.9976681

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Fusion Genomic Features for RNF213-HSD17B14


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RNF213-HSD17B14


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:78286967/chr19:49318398)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.HSD17B14

Q9BPX1

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3-beta,17-beta-diol (in vitro). {ECO:0000269|PubMed:17067289}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRNF213chr17:78286967chr19:49318398ENST00000319921+1517343_3749371064.0Coiled coilOntology_term=ECO:0000255
HgeneRNF213chr17:78286967chr19:49318398ENST00000508628+1669343_3749865257.0Coiled coilOntology_term=ECO:0000255
HgeneRNF213chr17:78286967chr19:49318398ENST00000582970+1568343_3749375208.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRNF213chr17:78286967chr19:49318398ENST00000319921+15173997_40369371064.0Zinc fingerRING-type
HgeneRNF213chr17:78286967chr19:49318398ENST00000508628+16693997_40369865257.0Zinc fingerRING-type
HgeneRNF213chr17:78286967chr19:49318398ENST00000582970+15683997_40369375208.0Zinc fingerRING-type
TgeneHSD17B14chr17:78286967chr19:49318398ENST000002632784913_40123271.0Nucleotide bindingNAD


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Fusion Gene Sequence for RNF213-HSD17B14


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>74974_74974_1_RNF213-HSD17B14_RNF213_chr17_78286967_ENST00000319921_HSD17B14_chr19_49318398_ENST00000263278_length(transcript)=3554nt_BP=2952nt
GCGCGCGGCAGGCGGCGAGCTCGGGGGCCGCAGAAAATGAAACTGAAGCCGTGGTCACGTGACAGGACATGTAGTATATAGCAGGCTGCC
AGCGACTCCTGCTCTTGCTTCTGGATCTGCAGGGCAGTCCCAGCAGGACCCATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGAGGAA
ACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCCATAGCAGATTCTGAGAACAATAACTCCACAATGGCGTCG
GCCTCGGAGGGTGAAATGGAGTGTGGGCAGGAGCTGAAGGAGGAAGGGGGCCCGTGCTTGTTCCCGGGCTCAGACAGTTGGCAAGAAAAC
CCCGAGGAGCCCTGTTCCAAAGCCTCCTGGACCGTCCAAGAAAGCAAAAAGAAGAAAAGGAAGAAGAAAAAGAAGGGGAACAAGTCCGCT
TCCTCAGAGCTGGCTTCCTTGCCCCTTTCTCCTGCCAGCCCCTGTCACCTGACTTTGCTTTCAAACCCGTGGCCTCAGGACACAGCCCTG
CCCCACAGCCAAGCCCAGCAGAGTGGCCCCACTGGCCAGCCGAGCCAGCCCCCAGGCACAGCCACCACGCCACTGGAGGGTGACGGCCTC
TCCGCGCCCACCGAGGTTGGCGACAGCCCCCTGCAGGCCCAGGCTTTGGGAGAGGCAGGAGTGGCCACAGGAAGTGAGGCTCAGAGCAGC
CCGCAATTCCAGGACCACACGGAAGGGGAGGACCAGGACGCTTCCATCCCCTCTGGGGGCAGAGGCCTGTCCCAGGAGGGGACCGGTCCC
CCCACCTCTGCTGGTGAAGGCCATTCTAGGACTGAAGATGCTGCCCAGGAGCTCCTGTTGCCTGAGTCAAAAGGAGGCAGCTCTGAGCCC
GGGACAGAACTGCAGACCACCGAGCAACAGGCAGGGGCCTCAGCCTCTATGGCAGTTGATGCTGTAGCTGAGCCAGCCAATGCAGTTAAA
GGGGCCGGGAAGGAAATGAAAGAGAAGACCCAGAGAATGAAACAGCCACCAGCAACCACTCCTCCTTTCAAAACACACTGCCAGGAAGCT
GAGACCAAGACCAAGGACGAGATGGCTGCTGCTGAAGAAAAAGTCGGTAAGAATGAACAAGGGGAGCCTGAAGACCTCAAGAAGCCAGAG
GGGAAGAACAGAAGTGCAGCTGCTGTGAAAAACGAGAAGGAGCAAAAAAACCAGGAAGCAGATGTCCAGGAAGTGAAGGCAAGCACGCTG
AGCCCGGGTGGAGGAGTCACCGTGTTCTTCCACGCCATCATCTCTCTTCATTTCCCATTCAATCCTGACCTCCATAAAGTCTTCATCAGA
GGAGGAGAAGAATTTGGGGAGTCAAAATGGGACAGCAATATCTGTGAGCTGCACTACACCAGAGACTTGGGTCATGACCGCGTTCTTGTT
GAAGGCATTGTCTGCATTTCCAAGAAGCACCTAGATAAATACATTCCTTACAAGTACGTCATTTATAATGGGGAATCTTTTGAGTATGAG
TTCATTTACAAGCACCAGCAGAAGAAGGGCGAGTACGTCAACCGCTGTCTGTTCATAAAATCTTCACTTCTGGGCTCAGGAGACTGGCAT
CAGTACTATGACATAGTTTATATGAAGCCTCATGGGAGACTCCAGAAAGTCATGAACCACATCACAGACGGGCCGAGGAAGGACCTGGTG
AAGGGGAAGCAGATTGCCGCTGCGCTCATGCTGGACAGCACCTTCAGCATCCTGCAGACCTGGGACACCATCAACCTGAACAGCTTCTTC
ACCCAGTTCGAGCAGTTTTGCTTTGTCCTGCAACAGCCTATGATTTATGAAGGACAGGCACAGCTGTGGACCGATTTGCAGTACAGGGAG
AAAGAGGTGAAGAGATACCTGTGGCAACATCTGAAAAAACACGTGGTACCATTGCCGGACGGAAAAAGCACGGACTTTTTGCCTGTGGAC
TGCCCAGTGAGGAGTAAACTGAAAACAGGCCTGATTGTCCTTTTTGTAGTGGAAAAAATTGAGCTTTTATTAGAAGGCAGCCTGGACTGG
TTGTGTCACCTCCTAACCTCAGATGCCAGCTCACCAGATGAGTTTCACCGTGACCTAAGCCACATCCTTGGGATACCTCAGAGCTGGCGG
CTGTACCTGGTGAACCTGTGCCAAAGATGCATGGACACAAGGACGTACACCTGGCTGGGCGCCCTGCCTGTCCTGCACTGCTGTATGGAG
CTGGCCCCGCGGCACAAGGATGCCTGGAGACAGCCTGAGGACACCTGGGCCGCTCTGGAGGGACTCTCCTTCTCACCGTTCCGGGAACAA
ATGCTAGATACGAGTTCCCTACTTCAGTTTATGAGAGAGAAGCAGCATTTGCTGAGCATAGACGAGCCTCTCTTCCGGTCCTGGTTTAGT
CTGCTACCTCTGAGTCACCTGGTTATGTATATGGAAAACTTCATTGAGCACCTGGGTCGTTTTCCTGCTCATATCCTGGACTGTCTTTCA
GGGATTTACTACCGGCTTCCGGGACTTGAGCAAGTCTTGAATACGCAGGATGTTCAGGATGTTCAGAACGTTCAGAACATTTTAGAAATG
CTGTTGCGACTCCTGGACACTTACCGGGACAAGATTCCCGAGGAGGCCTTGTCACCATCCTACCTGACTGTGTGTCTGAAACTGCATGAA
GCCATCTGCAGCAGCACAAAGCTACTTAAGTTTTACGAGCTGCCAGCCTTATCTGCCGAGATTGTCTGCAGAATGATTAGACTTCTATCT
CTGGTGGATTCTGCAGGACAGAGAGATGAAACTGGAAATAATTCAGTCCAAACAGTCTTCCAAGGGACCCTTGCTGCTACGAAAAGGTGG
CTCCGAGAAGTTTTTACAAAGAACATGCTCACATCTTCAGGTGCCTCATTCACATACGTCAAGGAAATTGAGCTCGCCCTCCCCTACCTG
CGGAAGAGTCAAGGGAATGTCATCAACATCTCCAGCCTGGTGGGGGCAATCGGCCAGGCCCAGGCAGTTCCCTATGTGGCCACCAAGGGG
GCAGTAACAGCCATGACCAAAGCTTTGGCCCTGGATGAAAGTCCATATGGTGTCCGAGTCAACTGTATCTCCCCAGGAAACATCTGGACC
CCGCTGTGGGAGGAGCTGGCAGCCTTAATGCCAGACCCTAGGGCCACAATCCGAGAGGGCATGCTGGCCCAGCCACTGGGCCGCATGGGC
CAGCCCGCTGAGGTCGGGGCTGCGGCAGTGTTCCTGGCCTCCGAAGCCAACTTCTGCACGGGCATTGAACTGCTCGTGACGGGGGGTGCA
GAGCTGGGGTACGGGTGCAAGGCCAGTCGGAGCACCCCCGTGGACGCCCCCGATATCCCTTCCTGATTTCTCTCATTTCTACTTGGGGCC
CCCTTCCTAGGACTCTCCCACCCCAAACTCCAACCTGTATCAGATGCAGCCCCCAAGCCCTTAGACTCTAAGCCCAGTTAGCAAGGTGCC

>74974_74974_1_RNF213-HSD17B14_RNF213_chr17_78286967_ENST00000319921_HSD17B14_chr19_49318398_ENST00000263278_length(amino acids)=1084AA_BP=937
MECPSCQHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGGPCLFPGSDSWQENPEEPCSKASWTVQESKK
KKRKKKKKGNKSASSELASLPLSPASPCHLTLLSNPWPQDTALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALG
EAGVATGSEAQSSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQELLLPESKGGSSEPGTELQTTEQQAGASASM
AVDAVAEPANAVKGAGKEMKEKTQRMKQPPATTPPFKTHCQEAETKTKDEMAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKN
QEADVQEVKASTLSPGGGVTVFFHAIISLHFPFNPDLHKVFIRGGEEFGESKWDSNICELHYTRDLGHDRVLVEGIVCISKKHLDKYIPY
KYVIYNGESFEYEFIYKHQQKKGEYVNRCLFIKSSLLGSGDWHQYYDIVYMKPHGRLQKVMNHITDGPRKDLVKGKQIAAALMLDSTFSI
LQTWDTINLNSFFTQFEQFCFVLQQPMIYEGQAQLWTDLQYREKEVKRYLWQHLKKHVVPLPDGKSTDFLPVDCPVRSKLKTGLIVLFVV
EKIELLLEGSLDWLCHLLTSDASSPDEFHRDLSHILGIPQSWRLYLVNLCQRCMDTRTYTWLGALPVLHCCMELAPRHKDAWRQPEDTWA
ALEGLSFSPFREQMLDTSSLLQFMREKQHLLSIDEPLFRSWFSLLPLSHLVMYMENFIEHLGRFPAHILDCLSGIYYRLPGLEQVLNTQD
VQDVQNVQNILEMLLRLLDTYRDKIPEEALSPSYLTVCLKLHEAICSSTKLLKFYELPALSAEIVCRMIRLLSLVDSAGQRDETGNNSVQ
TVFQGTLAATKRWLREVFTKNMLTSSGASFTYVKEIELALPYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYG
VRVNCISPGNIWTPLWEELAALMPDPRATIREGMLAQPLGRMGQPAEVGAAAVFLASEANFCTGIELLVTGGAELGYGCKASRSTPVDAP

--------------------------------------------------------------
>74974_74974_2_RNF213-HSD17B14_RNF213_chr17_78286967_ENST00000319921_HSD17B14_chr19_49318398_ENST00000599157_length(transcript)=3547nt_BP=2952nt
GCGCGCGGCAGGCGGCGAGCTCGGGGGCCGCAGAAAATGAAACTGAAGCCGTGGTCACGTGACAGGACATGTAGTATATAGCAGGCTGCC
AGCGACTCCTGCTCTTGCTTCTGGATCTGCAGGGCAGTCCCAGCAGGACCCATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGAGGAA
ACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCCATAGCAGATTCTGAGAACAATAACTCCACAATGGCGTCG
GCCTCGGAGGGTGAAATGGAGTGTGGGCAGGAGCTGAAGGAGGAAGGGGGCCCGTGCTTGTTCCCGGGCTCAGACAGTTGGCAAGAAAAC
CCCGAGGAGCCCTGTTCCAAAGCCTCCTGGACCGTCCAAGAAAGCAAAAAGAAGAAAAGGAAGAAGAAAAAGAAGGGGAACAAGTCCGCT
TCCTCAGAGCTGGCTTCCTTGCCCCTTTCTCCTGCCAGCCCCTGTCACCTGACTTTGCTTTCAAACCCGTGGCCTCAGGACACAGCCCTG
CCCCACAGCCAAGCCCAGCAGAGTGGCCCCACTGGCCAGCCGAGCCAGCCCCCAGGCACAGCCACCACGCCACTGGAGGGTGACGGCCTC
TCCGCGCCCACCGAGGTTGGCGACAGCCCCCTGCAGGCCCAGGCTTTGGGAGAGGCAGGAGTGGCCACAGGAAGTGAGGCTCAGAGCAGC
CCGCAATTCCAGGACCACACGGAAGGGGAGGACCAGGACGCTTCCATCCCCTCTGGGGGCAGAGGCCTGTCCCAGGAGGGGACCGGTCCC
CCCACCTCTGCTGGTGAAGGCCATTCTAGGACTGAAGATGCTGCCCAGGAGCTCCTGTTGCCTGAGTCAAAAGGAGGCAGCTCTGAGCCC
GGGACAGAACTGCAGACCACCGAGCAACAGGCAGGGGCCTCAGCCTCTATGGCAGTTGATGCTGTAGCTGAGCCAGCCAATGCAGTTAAA
GGGGCCGGGAAGGAAATGAAAGAGAAGACCCAGAGAATGAAACAGCCACCAGCAACCACTCCTCCTTTCAAAACACACTGCCAGGAAGCT
GAGACCAAGACCAAGGACGAGATGGCTGCTGCTGAAGAAAAAGTCGGTAAGAATGAACAAGGGGAGCCTGAAGACCTCAAGAAGCCAGAG
GGGAAGAACAGAAGTGCAGCTGCTGTGAAAAACGAGAAGGAGCAAAAAAACCAGGAAGCAGATGTCCAGGAAGTGAAGGCAAGCACGCTG
AGCCCGGGTGGAGGAGTCACCGTGTTCTTCCACGCCATCATCTCTCTTCATTTCCCATTCAATCCTGACCTCCATAAAGTCTTCATCAGA
GGAGGAGAAGAATTTGGGGAGTCAAAATGGGACAGCAATATCTGTGAGCTGCACTACACCAGAGACTTGGGTCATGACCGCGTTCTTGTT
GAAGGCATTGTCTGCATTTCCAAGAAGCACCTAGATAAATACATTCCTTACAAGTACGTCATTTATAATGGGGAATCTTTTGAGTATGAG
TTCATTTACAAGCACCAGCAGAAGAAGGGCGAGTACGTCAACCGCTGTCTGTTCATAAAATCTTCACTTCTGGGCTCAGGAGACTGGCAT
CAGTACTATGACATAGTTTATATGAAGCCTCATGGGAGACTCCAGAAAGTCATGAACCACATCACAGACGGGCCGAGGAAGGACCTGGTG
AAGGGGAAGCAGATTGCCGCTGCGCTCATGCTGGACAGCACCTTCAGCATCCTGCAGACCTGGGACACCATCAACCTGAACAGCTTCTTC
ACCCAGTTCGAGCAGTTTTGCTTTGTCCTGCAACAGCCTATGATTTATGAAGGACAGGCACAGCTGTGGACCGATTTGCAGTACAGGGAG
AAAGAGGTGAAGAGATACCTGTGGCAACATCTGAAAAAACACGTGGTACCATTGCCGGACGGAAAAAGCACGGACTTTTTGCCTGTGGAC
TGCCCAGTGAGGAGTAAACTGAAAACAGGCCTGATTGTCCTTTTTGTAGTGGAAAAAATTGAGCTTTTATTAGAAGGCAGCCTGGACTGG
TTGTGTCACCTCCTAACCTCAGATGCCAGCTCACCAGATGAGTTTCACCGTGACCTAAGCCACATCCTTGGGATACCTCAGAGCTGGCGG
CTGTACCTGGTGAACCTGTGCCAAAGATGCATGGACACAAGGACGTACACCTGGCTGGGCGCCCTGCCTGTCCTGCACTGCTGTATGGAG
CTGGCCCCGCGGCACAAGGATGCCTGGAGACAGCCTGAGGACACCTGGGCCGCTCTGGAGGGACTCTCCTTCTCACCGTTCCGGGAACAA
ATGCTAGATACGAGTTCCCTACTTCAGTTTATGAGAGAGAAGCAGCATTTGCTGAGCATAGACGAGCCTCTCTTCCGGTCCTGGTTTAGT
CTGCTACCTCTGAGTCACCTGGTTATGTATATGGAAAACTTCATTGAGCACCTGGGTCGTTTTCCTGCTCATATCCTGGACTGTCTTTCA
GGGATTTACTACCGGCTTCCGGGACTTGAGCAAGTCTTGAATACGCAGGATGTTCAGGATGTTCAGAACGTTCAGAACATTTTAGAAATG
CTGTTGCGACTCCTGGACACTTACCGGGACAAGATTCCCGAGGAGGCCTTGTCACCATCCTACCTGACTGTGTGTCTGAAACTGCATGAA
GCCATCTGCAGCAGCACAAAGCTACTTAAGTTTTACGAGCTGCCAGCCTTATCTGCCGAGATTGTCTGCAGAATGATTAGACTTCTATCT
CTGGTGGATTCTGCAGGACAGAGAGATGAAACTGGAAATAATTCAGTCCAAACAGTCTTCCAAGGGACCCTTGCTGCTACGAAAAGGTGG
CTCCGAGAAGTTTTTACAAAGAACATGCTCACATCTTCAGGTGCCTCATTCACATACGTCAAGGAAATTGAGCTCGCCCTCCCCTACCTG
CGGAAGAGTCAAGGGAATGTCATCAACATCTCCAGCCTGGTGGGGGCAATCGGCCAGGCCCAGGCAGTTCCCTATGTGGCCACCAAGGGG
GCAGTAACAGCCATGACCAAAGCTTTGGCCCTGGATGAAAGTCCATATGGTGTCCGAGTCAACTGTATCTCCCCAGGAAACATCTGGACC
CCGCTGTGGGAGGAGCTGGCAGCCTTAATGCCAGACCCTAGGGCCACAATCCGAGAGGGCATGCTGGCCCAGCCACTGGGCCGCATGGGC
CAGCCCGCTGAGGTCGGGGCTGCGGCAGTGTTCCTGGCCTCCGAAGCCAACTTCTGCACGGGCATTGAACTGCTCGTGACGGGGGGTGCA
GAGCTGGGGTACGGGTGCAAGGCCAGTCGGAGCACCCCCGTGGACGCCCCCGATATCCCTTCCTGATTTCTCTCATTTCTACTTGGGGCC
CCCTTCCTAGGACTCTCCCACCCCAAACTCCAACCTGTATCAGATGCAGCCCCCAAGCCCTTAGACTCTAAGCCCAGTTAGCAAGGTGCC

>74974_74974_2_RNF213-HSD17B14_RNF213_chr17_78286967_ENST00000319921_HSD17B14_chr19_49318398_ENST00000599157_length(amino acids)=1084AA_BP=937
MECPSCQHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGGPCLFPGSDSWQENPEEPCSKASWTVQESKK
KKRKKKKKGNKSASSELASLPLSPASPCHLTLLSNPWPQDTALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALG
EAGVATGSEAQSSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQELLLPESKGGSSEPGTELQTTEQQAGASASM
AVDAVAEPANAVKGAGKEMKEKTQRMKQPPATTPPFKTHCQEAETKTKDEMAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKN
QEADVQEVKASTLSPGGGVTVFFHAIISLHFPFNPDLHKVFIRGGEEFGESKWDSNICELHYTRDLGHDRVLVEGIVCISKKHLDKYIPY
KYVIYNGESFEYEFIYKHQQKKGEYVNRCLFIKSSLLGSGDWHQYYDIVYMKPHGRLQKVMNHITDGPRKDLVKGKQIAAALMLDSTFSI
LQTWDTINLNSFFTQFEQFCFVLQQPMIYEGQAQLWTDLQYREKEVKRYLWQHLKKHVVPLPDGKSTDFLPVDCPVRSKLKTGLIVLFVV
EKIELLLEGSLDWLCHLLTSDASSPDEFHRDLSHILGIPQSWRLYLVNLCQRCMDTRTYTWLGALPVLHCCMELAPRHKDAWRQPEDTWA
ALEGLSFSPFREQMLDTSSLLQFMREKQHLLSIDEPLFRSWFSLLPLSHLVMYMENFIEHLGRFPAHILDCLSGIYYRLPGLEQVLNTQD
VQDVQNVQNILEMLLRLLDTYRDKIPEEALSPSYLTVCLKLHEAICSSTKLLKFYELPALSAEIVCRMIRLLSLVDSAGQRDETGNNSVQ
TVFQGTLAATKRWLREVFTKNMLTSSGASFTYVKEIELALPYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYG
VRVNCISPGNIWTPLWEELAALMPDPRATIREGMLAQPLGRMGQPAEVGAAAVFLASEANFCTGIELLVTGGAELGYGCKASRSTPVDAP

--------------------------------------------------------------
>74974_74974_3_RNF213-HSD17B14_RNF213_chr17_78286967_ENST00000456466_HSD17B14_chr19_49318398_ENST00000263278_length(transcript)=3556nt_BP=2954nt
CAGCGCGCGGCAGGCGGCGAGCTCGGGGGCCGCAGAAAATGAAACTGAAGCCGTGGTCACGTGACAGGACATGTAGTATATAGCAGGCTG
CCAGCGACTCCTGCTCTTGCTTCTGGATCTGCAGGGCAGTCCCAGCAGGACCCATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGAGG
AAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCCATAGCAGATTCTGAGAACAATAACTCCACAATGGCGT
CGGCCTCGGAGGGTGAAATGGAGTGTGGGCAGGAGCTGAAGGAGGAAGGGGGCCCGTGCTTGTTCCCGGGCTCAGACAGTTGGCAAGAAA
ACCCCGAGGAGCCCTGTTCCAAAGCCTCCTGGACCGTCCAAGAAAGCAAAAAGAAGAAAAGGAAGAAGAAAAAGAAGGGGAACAAGTCCG
CTTCCTCAGAGCTGGCTTCCTTGCCCCTTTCTCCTGCCAGCCCCTGTCACCTGACTTTGCTTTCAAACCCGTGGCCTCAGGACACAGCCC
TGCCCCACAGCCAAGCCCAGCAGAGTGGCCCCACTGGCCAGCCGAGCCAGCCCCCAGGCACAGCCACCACGCCACTGGAGGGTGACGGCC
TCTCCGCGCCCACCGAGGTTGGCGACAGCCCCCTGCAGGCCCAGGCTTTGGGAGAGGCAGGAGTGGCCACAGGAAGTGAGGCTCAGAGCA
GCCCGCAATTCCAGGACCACACGGAAGGGGAGGACCAGGACGCTTCCATCCCCTCTGGGGGCAGAGGCCTGTCCCAGGAGGGGACCGGTC
CCCCCACCTCTGCTGGTGAAGGCCATTCTAGGACTGAAGATGCTGCCCAGGAGCTCCTGTTGCCTGAGTCAAAAGGAGGCAGCTCTGAGC
CCGGGACAGAACTGCAGACCACCGAGCAACAGGCAGGGGCCTCAGCCTCTATGGCAGTTGATGCTGTAGCTGAGCCAGCCAATGCAGTTA
AAGGGGCCGGGAAGGAAATGAAAGAGAAGACCCAGAGAATGAAACAGCCACCAGCAACCACTCCTCCTTTCAAAACACACTGCCAGGAAG
CTGAGACCAAGACCAAGGACGAGATGGCTGCTGCTGAAGAAAAAGTCGGTAAGAATGAACAAGGGGAGCCTGAAGACCTCAAGAAGCCAG
AGGGGAAGAACAGAAGTGCAGCTGCTGTGAAAAACGAGAAGGAGCAAAAAAACCAGGAAGCAGATGTCCAGGAAGTGAAGGCAAGCACGC
TGAGCCCGGGTGGAGGAGTCACCGTGTTCTTCCACGCCATCATCTCTCTTCATTTCCCATTCAATCCTGACCTCCATAAAGTCTTCATCA
GAGGAGGAGAAGAATTTGGGGAGTCAAAATGGGACAGCAATATCTGTGAGCTGCACTACACCAGAGACTTGGGTCATGACCGCGTTCTTG
TTGAAGGCATTGTCTGCATTTCCAAGAAGCACCTAGATAAATACATTCCTTACAAGTACGTCATTTATAATGGGGAATCTTTTGAGTATG
AGTTCATTTACAAGCACCAGCAGAAGAAGGGCGAGTACGTCAACCGCTGTCTGTTCATAAAATCTTCACTTCTGGGCTCAGGAGACTGGC
ATCAGTACTATGACATAGTTTATATGAAGCCTCATGGGAGACTCCAGAAAGTCATGAACCACATCACAGACGGGCCGAGGAAGGACCTGG
TGAAGGGGAAGCAGATTGCCGCTGCGCTCATGCTGGACAGCACCTTCAGCATCCTGCAGACCTGGGACACCATCAACCTGAACAGCTTCT
TCACCCAGTTCGAGCAGTTTTGCTTTGTCCTGCAACAGCCTATGATTTATGAAGGACAGGCACAGCTGTGGACCGATTTGCAGTACAGGG
AGAAAGAGGTGAAGAGATACCTGTGGCAACATCTGAAAAAACACGTGGTACCATTGCCGGACGGAAAAAGCACGGACTTTTTGCCTGTGG
ACTGCCCAGTGAGGAGTAAACTGAAAACAGGCCTGATTGTCCTTTTTGTAGTGGAAAAAATTGAGCTTTTATTAGAAGGCAGCCTGGACT
GGTTGTGTCACCTCCTAACCTCAGATGCCAGCTCACCAGATGAGTTTCACCGTGACCTAAGCCACATCCTTGGGATACCTCAGAGCTGGC
GGCTGTACCTGGTGAACCTGTGCCAAAGATGCATGGACACAAGGACGTACACCTGGCTGGGCGCCCTGCCTGTCCTGCACTGCTGTATGG
AGCTGGCCCCGCGGCACAAGGATGCCTGGAGACAGCCTGAGGACACCTGGGCCGCTCTGGAGGGACTCTCCTTCTCACCGTTCCGGGAAC
AAATGCTAGATACGAGTTCCCTACTTCAGTTTATGAGAGAGAAGCAGCATTTGCTGAGCATAGACGAGCCTCTCTTCCGGTCCTGGTTTA
GTCTGCTACCTCTGAGTCACCTGGTTATGTATATGGAAAACTTCATTGAGCACCTGGGTCGTTTTCCTGCTCATATCCTGGACTGTCTTT
CAGGGATTTACTACCGGCTTCCGGGACTTGAGCAAGTCTTGAATACGCAGGATGTTCAGGATGTTCAGAACGTTCAGAACATTTTAGAAA
TGCTGTTGCGACTCCTGGACACTTACCGGGACAAGATTCCCGAGGAGGCCTTGTCACCATCCTACCTGACTGTGTGTCTGAAACTGCATG
AAGCCATCTGCAGCAGCACAAAGCTACTTAAGTTTTACGAGCTGCCAGCCTTATCTGCCGAGATTGTCTGCAGAATGATTAGACTTCTAT
CTCTGGTGGATTCTGCAGGACAGAGAGATGAAACTGGAAATAATTCAGTCCAAACAGTCTTCCAAGGGACCCTTGCTGCTACGAAAAGGT
GGCTCCGAGAAGTTTTTACAAAGAACATGCTCACATCTTCAGGTGCCTCATTCACATACGTCAAGGAAATTGAGCTCGCCCTCCCCTACC
TGCGGAAGAGTCAAGGGAATGTCATCAACATCTCCAGCCTGGTGGGGGCAATCGGCCAGGCCCAGGCAGTTCCCTATGTGGCCACCAAGG
GGGCAGTAACAGCCATGACCAAAGCTTTGGCCCTGGATGAAAGTCCATATGGTGTCCGAGTCAACTGTATCTCCCCAGGAAACATCTGGA
CCCCGCTGTGGGAGGAGCTGGCAGCCTTAATGCCAGACCCTAGGGCCACAATCCGAGAGGGCATGCTGGCCCAGCCACTGGGCCGCATGG
GCCAGCCCGCTGAGGTCGGGGCTGCGGCAGTGTTCCTGGCCTCCGAAGCCAACTTCTGCACGGGCATTGAACTGCTCGTGACGGGGGGTG
CAGAGCTGGGGTACGGGTGCAAGGCCAGTCGGAGCACCCCCGTGGACGCCCCCGATATCCCTTCCTGATTTCTCTCATTTCTACTTGGGG
CCCCCTTCCTAGGACTCTCCCACCCCAAACTCCAACCTGTATCAGATGCAGCCCCCAAGCCCTTAGACTCTAAGCCCAGTTAGCAAGGTG

>74974_74974_3_RNF213-HSD17B14_RNF213_chr17_78286967_ENST00000456466_HSD17B14_chr19_49318398_ENST00000263278_length(amino acids)=1084AA_BP=937
MECPSCQHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGGPCLFPGSDSWQENPEEPCSKASWTVQESKK
KKRKKKKKGNKSASSELASLPLSPASPCHLTLLSNPWPQDTALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALG
EAGVATGSEAQSSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQELLLPESKGGSSEPGTELQTTEQQAGASASM
AVDAVAEPANAVKGAGKEMKEKTQRMKQPPATTPPFKTHCQEAETKTKDEMAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKN
QEADVQEVKASTLSPGGGVTVFFHAIISLHFPFNPDLHKVFIRGGEEFGESKWDSNICELHYTRDLGHDRVLVEGIVCISKKHLDKYIPY
KYVIYNGESFEYEFIYKHQQKKGEYVNRCLFIKSSLLGSGDWHQYYDIVYMKPHGRLQKVMNHITDGPRKDLVKGKQIAAALMLDSTFSI
LQTWDTINLNSFFTQFEQFCFVLQQPMIYEGQAQLWTDLQYREKEVKRYLWQHLKKHVVPLPDGKSTDFLPVDCPVRSKLKTGLIVLFVV
EKIELLLEGSLDWLCHLLTSDASSPDEFHRDLSHILGIPQSWRLYLVNLCQRCMDTRTYTWLGALPVLHCCMELAPRHKDAWRQPEDTWA
ALEGLSFSPFREQMLDTSSLLQFMREKQHLLSIDEPLFRSWFSLLPLSHLVMYMENFIEHLGRFPAHILDCLSGIYYRLPGLEQVLNTQD
VQDVQNVQNILEMLLRLLDTYRDKIPEEALSPSYLTVCLKLHEAICSSTKLLKFYELPALSAEIVCRMIRLLSLVDSAGQRDETGNNSVQ
TVFQGTLAATKRWLREVFTKNMLTSSGASFTYVKEIELALPYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYG
VRVNCISPGNIWTPLWEELAALMPDPRATIREGMLAQPLGRMGQPAEVGAAAVFLASEANFCTGIELLVTGGAELGYGCKASRSTPVDAP

--------------------------------------------------------------
>74974_74974_4_RNF213-HSD17B14_RNF213_chr17_78286967_ENST00000456466_HSD17B14_chr19_49318398_ENST00000599157_length(transcript)=3549nt_BP=2954nt
CAGCGCGCGGCAGGCGGCGAGCTCGGGGGCCGCAGAAAATGAAACTGAAGCCGTGGTCACGTGACAGGACATGTAGTATATAGCAGGCTG
CCAGCGACTCCTGCTCTTGCTTCTGGATCTGCAGGGCAGTCCCAGCAGGACCCATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGAGG
AAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCCATAGCAGATTCTGAGAACAATAACTCCACAATGGCGT
CGGCCTCGGAGGGTGAAATGGAGTGTGGGCAGGAGCTGAAGGAGGAAGGGGGCCCGTGCTTGTTCCCGGGCTCAGACAGTTGGCAAGAAA
ACCCCGAGGAGCCCTGTTCCAAAGCCTCCTGGACCGTCCAAGAAAGCAAAAAGAAGAAAAGGAAGAAGAAAAAGAAGGGGAACAAGTCCG
CTTCCTCAGAGCTGGCTTCCTTGCCCCTTTCTCCTGCCAGCCCCTGTCACCTGACTTTGCTTTCAAACCCGTGGCCTCAGGACACAGCCC
TGCCCCACAGCCAAGCCCAGCAGAGTGGCCCCACTGGCCAGCCGAGCCAGCCCCCAGGCACAGCCACCACGCCACTGGAGGGTGACGGCC
TCTCCGCGCCCACCGAGGTTGGCGACAGCCCCCTGCAGGCCCAGGCTTTGGGAGAGGCAGGAGTGGCCACAGGAAGTGAGGCTCAGAGCA
GCCCGCAATTCCAGGACCACACGGAAGGGGAGGACCAGGACGCTTCCATCCCCTCTGGGGGCAGAGGCCTGTCCCAGGAGGGGACCGGTC
CCCCCACCTCTGCTGGTGAAGGCCATTCTAGGACTGAAGATGCTGCCCAGGAGCTCCTGTTGCCTGAGTCAAAAGGAGGCAGCTCTGAGC
CCGGGACAGAACTGCAGACCACCGAGCAACAGGCAGGGGCCTCAGCCTCTATGGCAGTTGATGCTGTAGCTGAGCCAGCCAATGCAGTTA
AAGGGGCCGGGAAGGAAATGAAAGAGAAGACCCAGAGAATGAAACAGCCACCAGCAACCACTCCTCCTTTCAAAACACACTGCCAGGAAG
CTGAGACCAAGACCAAGGACGAGATGGCTGCTGCTGAAGAAAAAGTCGGTAAGAATGAACAAGGGGAGCCTGAAGACCTCAAGAAGCCAG
AGGGGAAGAACAGAAGTGCAGCTGCTGTGAAAAACGAGAAGGAGCAAAAAAACCAGGAAGCAGATGTCCAGGAAGTGAAGGCAAGCACGC
TGAGCCCGGGTGGAGGAGTCACCGTGTTCTTCCACGCCATCATCTCTCTTCATTTCCCATTCAATCCTGACCTCCATAAAGTCTTCATCA
GAGGAGGAGAAGAATTTGGGGAGTCAAAATGGGACAGCAATATCTGTGAGCTGCACTACACCAGAGACTTGGGTCATGACCGCGTTCTTG
TTGAAGGCATTGTCTGCATTTCCAAGAAGCACCTAGATAAATACATTCCTTACAAGTACGTCATTTATAATGGGGAATCTTTTGAGTATG
AGTTCATTTACAAGCACCAGCAGAAGAAGGGCGAGTACGTCAACCGCTGTCTGTTCATAAAATCTTCACTTCTGGGCTCAGGAGACTGGC
ATCAGTACTATGACATAGTTTATATGAAGCCTCATGGGAGACTCCAGAAAGTCATGAACCACATCACAGACGGGCCGAGGAAGGACCTGG
TGAAGGGGAAGCAGATTGCCGCTGCGCTCATGCTGGACAGCACCTTCAGCATCCTGCAGACCTGGGACACCATCAACCTGAACAGCTTCT
TCACCCAGTTCGAGCAGTTTTGCTTTGTCCTGCAACAGCCTATGATTTATGAAGGACAGGCACAGCTGTGGACCGATTTGCAGTACAGGG
AGAAAGAGGTGAAGAGATACCTGTGGCAACATCTGAAAAAACACGTGGTACCATTGCCGGACGGAAAAAGCACGGACTTTTTGCCTGTGG
ACTGCCCAGTGAGGAGTAAACTGAAAACAGGCCTGATTGTCCTTTTTGTAGTGGAAAAAATTGAGCTTTTATTAGAAGGCAGCCTGGACT
GGTTGTGTCACCTCCTAACCTCAGATGCCAGCTCACCAGATGAGTTTCACCGTGACCTAAGCCACATCCTTGGGATACCTCAGAGCTGGC
GGCTGTACCTGGTGAACCTGTGCCAAAGATGCATGGACACAAGGACGTACACCTGGCTGGGCGCCCTGCCTGTCCTGCACTGCTGTATGG
AGCTGGCCCCGCGGCACAAGGATGCCTGGAGACAGCCTGAGGACACCTGGGCCGCTCTGGAGGGACTCTCCTTCTCACCGTTCCGGGAAC
AAATGCTAGATACGAGTTCCCTACTTCAGTTTATGAGAGAGAAGCAGCATTTGCTGAGCATAGACGAGCCTCTCTTCCGGTCCTGGTTTA
GTCTGCTACCTCTGAGTCACCTGGTTATGTATATGGAAAACTTCATTGAGCACCTGGGTCGTTTTCCTGCTCATATCCTGGACTGTCTTT
CAGGGATTTACTACCGGCTTCCGGGACTTGAGCAAGTCTTGAATACGCAGGATGTTCAGGATGTTCAGAACGTTCAGAACATTTTAGAAA
TGCTGTTGCGACTCCTGGACACTTACCGGGACAAGATTCCCGAGGAGGCCTTGTCACCATCCTACCTGACTGTGTGTCTGAAACTGCATG
AAGCCATCTGCAGCAGCACAAAGCTACTTAAGTTTTACGAGCTGCCAGCCTTATCTGCCGAGATTGTCTGCAGAATGATTAGACTTCTAT
CTCTGGTGGATTCTGCAGGACAGAGAGATGAAACTGGAAATAATTCAGTCCAAACAGTCTTCCAAGGGACCCTTGCTGCTACGAAAAGGT
GGCTCCGAGAAGTTTTTACAAAGAACATGCTCACATCTTCAGGTGCCTCATTCACATACGTCAAGGAAATTGAGCTCGCCCTCCCCTACC
TGCGGAAGAGTCAAGGGAATGTCATCAACATCTCCAGCCTGGTGGGGGCAATCGGCCAGGCCCAGGCAGTTCCCTATGTGGCCACCAAGG
GGGCAGTAACAGCCATGACCAAAGCTTTGGCCCTGGATGAAAGTCCATATGGTGTCCGAGTCAACTGTATCTCCCCAGGAAACATCTGGA
CCCCGCTGTGGGAGGAGCTGGCAGCCTTAATGCCAGACCCTAGGGCCACAATCCGAGAGGGCATGCTGGCCCAGCCACTGGGCCGCATGG
GCCAGCCCGCTGAGGTCGGGGCTGCGGCAGTGTTCCTGGCCTCCGAAGCCAACTTCTGCACGGGCATTGAACTGCTCGTGACGGGGGGTG
CAGAGCTGGGGTACGGGTGCAAGGCCAGTCGGAGCACCCCCGTGGACGCCCCCGATATCCCTTCCTGATTTCTCTCATTTCTACTTGGGG
CCCCCTTCCTAGGACTCTCCCACCCCAAACTCCAACCTGTATCAGATGCAGCCCCCAAGCCCTTAGACTCTAAGCCCAGTTAGCAAGGTG

>74974_74974_4_RNF213-HSD17B14_RNF213_chr17_78286967_ENST00000456466_HSD17B14_chr19_49318398_ENST00000599157_length(amino acids)=1084AA_BP=937
MECPSCQHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGGPCLFPGSDSWQENPEEPCSKASWTVQESKK
KKRKKKKKGNKSASSELASLPLSPASPCHLTLLSNPWPQDTALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALG
EAGVATGSEAQSSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQELLLPESKGGSSEPGTELQTTEQQAGASASM
AVDAVAEPANAVKGAGKEMKEKTQRMKQPPATTPPFKTHCQEAETKTKDEMAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKN
QEADVQEVKASTLSPGGGVTVFFHAIISLHFPFNPDLHKVFIRGGEEFGESKWDSNICELHYTRDLGHDRVLVEGIVCISKKHLDKYIPY
KYVIYNGESFEYEFIYKHQQKKGEYVNRCLFIKSSLLGSGDWHQYYDIVYMKPHGRLQKVMNHITDGPRKDLVKGKQIAAALMLDSTFSI
LQTWDTINLNSFFTQFEQFCFVLQQPMIYEGQAQLWTDLQYREKEVKRYLWQHLKKHVVPLPDGKSTDFLPVDCPVRSKLKTGLIVLFVV
EKIELLLEGSLDWLCHLLTSDASSPDEFHRDLSHILGIPQSWRLYLVNLCQRCMDTRTYTWLGALPVLHCCMELAPRHKDAWRQPEDTWA
ALEGLSFSPFREQMLDTSSLLQFMREKQHLLSIDEPLFRSWFSLLPLSHLVMYMENFIEHLGRFPAHILDCLSGIYYRLPGLEQVLNTQD
VQDVQNVQNILEMLLRLLDTYRDKIPEEALSPSYLTVCLKLHEAICSSTKLLKFYELPALSAEIVCRMIRLLSLVDSAGQRDETGNNSVQ
TVFQGTLAATKRWLREVFTKNMLTSSGASFTYVKEIELALPYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYG
VRVNCISPGNIWTPLWEELAALMPDPRATIREGMLAQPLGRMGQPAEVGAAAVFLASEANFCTGIELLVTGGAELGYGCKASRSTPVDAP

--------------------------------------------------------------
>74974_74974_5_RNF213-HSD17B14_RNF213_chr17_78286967_ENST00000508628_HSD17B14_chr19_49318398_ENST00000263278_length(transcript)=3705nt_BP=3103nt
GACAGCGCGCGGCAGGCGGCGAGCTCGGGGGCCGCAGAAAATGAAACTGAAGCCGTGGTCACGTGACAGGACATGTAGTATATAGCAGGC
TGCCAGCGACTCCTGCTCTTGCTTCTGGATCTGCAGGGCAGTCCCAGCAGGACCCATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGA
GGAAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCCATAGCAGATTCTGAGAACAATAACTCCACAATGGC
GTCGGCCTCGGAGGGTGAAATGGAGTGTGGGCAGGAGCTGAAGGAGGAAGGGGGCCCGTGCTTGTTCCCGGGCTCAGACAGTTGGCAAGA
AAACCCCGAGGAGCCCTGTTCCAAAGCCTCCTGGACCGTCCAAGAAGGAGCTACATCAGAGGTTTTGGTAGATGCTGCTGTAGACCTCAT
ATCCGATGAATGGGAAGCTGCTAATGCCATACCCAGCAAGAGAAGGAAGCAGGATGCAGCCCCGCTTGAGGCCGCCAGCGTGCCTTCTGC
AGACTGTGAGCAGAGCAAAAAGAAGAAAAGGAAGAAGAAAAAGAAGGGGAACAAGTCCGCTTCCTCAGAGCTGGCTTCCTTGCCCCTTTC
TCCTGCCAGCCCCTGTCACCTGACTTTGCTTTCAAACCCGTGGCCTCAGGACACAGCCCTGCCCCACAGCCAAGCCCAGCAGAGTGGCCC
CACTGGCCAGCCGAGCCAGCCCCCAGGCACAGCCACCACGCCACTGGAGGGTGACGGCCTCTCCGCGCCCACCGAGGTTGGCGACAGCCC
CCTGCAGGCCCAGGCTTTGGGAGAGGCAGGAGTGGCCACAGGAAGTGAGGCTCAGAGCAGCCCGCAATTCCAGGACCACACGGAAGGGGA
GGACCAGGACGCTTCCATCCCCTCTGGGGGCAGAGGCCTGTCCCAGGAGGGGACCGGTCCCCCCACCTCTGCTGGTGAAGGCCATTCTAG
GACTGAAGATGCTGCCCAGGAGCTCCTGTTGCCTGAGTCAAAAGGAGGCAGCTCTGAGCCCGGGACAGAACTGCAGACCACCGAGCAACA
GGCAGGGGCCTCAGCCTCTATGGCAGTTGATGCTGTAGCTGAGCCAGCCAATGCAGTTAAAGGGGCCGGGAAGGAAATGAAAGAGAAGAC
CCAGAGAATGAAACAGCCACCAGCAACCACTCCTCCTTTCAAAACACACTGCCAGGAAGCTGAGACCAAGACCAAGGACGAGATGGCTGC
TGCTGAAGAAAAAGTCGGTAAGAATGAACAAGGGGAGCCTGAAGACCTCAAGAAGCCAGAGGGGAAGAACAGAAGTGCAGCTGCTGTGAA
AAACGAGAAGGAGCAAAAAAACCAGGAAGCAGATGTCCAGGAAGTGAAGGCAAGCACGCTGAGCCCGGGTGGAGGAGTCACCGTGTTCTT
CCACGCCATCATCTCTCTTCATTTCCCATTCAATCCTGACCTCCATAAAGTCTTCATCAGAGGAGGAGAAGAATTTGGGGAGTCAAAATG
GGACAGCAATATCTGTGAGCTGCACTACACCAGAGACTTGGGTCATGACCGCGTTCTTGTTGAAGGCATTGTCTGCATTTCCAAGAAGCA
CCTAGATAAATACATTCCTTACAAGTACGTCATTTATAATGGGGAATCTTTTGAGTATGAGTTCATTTACAAGCACCAGCAGAAGAAGGG
CGAGTACGTCAACCGCTGTCTGTTCATAAAATCTTCACTTCTGGGCTCAGGAGACTGGCATCAGTACTATGACATAGTTTATATGAAGCC
TCATGGGAGACTCCAGAAAGTCATGAACCACATCACAGACGGGCCGAGGAAGGACCTGGTGAAGGGGAAGCAGATTGCCGCTGCGCTCAT
GCTGGACAGCACCTTCAGCATCCTGCAGACCTGGGACACCATCAACCTGAACAGCTTCTTCACCCAGTTCGAGCAGTTTTGCTTTGTCCT
GCAACAGCCTATGATTTATGAAGGACAGGCACAGCTGTGGACCGATTTGCAGTACAGGGAGAAAGAGGTGAAGAGATACCTGTGGCAACA
TCTGAAAAAACACGTGGTACCATTGCCGGACGGAAAAAGCACGGACTTTTTGCCTGTGGACTGCCCAGTGAGGAGTAAACTGAAAACAGG
CCTGATTGTCCTTTTTGTAGTGGAAAAAATTGAGCTTTTATTAGAAGGCAGCCTGGACTGGTTGTGTCACCTCCTAACCTCAGATGCCAG
CTCACCAGATGAGTTTCACCGTGACCTAAGCCACATCCTTGGGATACCTCAGAGCTGGCGGCTGTACCTGGTGAACCTGTGCCAAAGATG
CATGGACACAAGGACGTACACCTGGCTGGGCGCCCTGCCTGTCCTGCACTGCTGTATGGAGCTGGCCCCGCGGCACAAGGATGCCTGGAG
ACAGCCTGAGGACACCTGGGCCGCTCTGGAGGGACTCTCCTTCTCACCGTTCCGGGAACAAATGCTAGATACGAGTTCCCTACTTCAGTT
TATGAGAGAGAAGCAGCATTTGCTGAGCATAGACGAGCCTCTCTTCCGGTCCTGGTTTAGTCTGCTACCTCTGAGTCACCTGGTTATGTA
TATGGAAAACTTCATTGAGCACCTGGGTCGTTTTCCTGCTCATATCCTGGACTGTCTTTCAGGGATTTACTACCGGCTTCCGGGACTTGA
GCAAGTCTTGAATACGCAGGATGTTCAGGATGTTCAGAACGTTCAGAACATTTTAGAAATGCTGTTGCGACTCCTGGACACTTACCGGGA
CAAGATTCCCGAGGAGGCCTTGTCACCATCCTACCTGACTGTGTGTCTGAAACTGCATGAAGCCATCTGCAGCAGCACAAAGCTACTTAA
GTTTTACGAGCTGCCAGCCTTATCTGCCGAGATTGTCTGCAGAATGATTAGACTTCTATCTCTGGTGGATTCTGCAGGACAGAGAGATGA
AACTGGAAATAATTCAGTCCAAACAGTCTTCCAAGGGACCCTTGCTGCTACGAAAAGGTGGCTCCGAGAAGTTTTTACAAAGAACATGCT
CACATCTTCAGGTGCCTCATTCACATACGTCAAGGAAATTGAGCTCGCCCTCCCCTACCTGCGGAAGAGTCAAGGGAATGTCATCAACAT
CTCCAGCCTGGTGGGGGCAATCGGCCAGGCCCAGGCAGTTCCCTATGTGGCCACCAAGGGGGCAGTAACAGCCATGACCAAAGCTTTGGC
CCTGGATGAAAGTCCATATGGTGTCCGAGTCAACTGTATCTCCCCAGGAAACATCTGGACCCCGCTGTGGGAGGAGCTGGCAGCCTTAAT
GCCAGACCCTAGGGCCACAATCCGAGAGGGCATGCTGGCCCAGCCACTGGGCCGCATGGGCCAGCCCGCTGAGGTCGGGGCTGCGGCAGT
GTTCCTGGCCTCCGAAGCCAACTTCTGCACGGGCATTGAACTGCTCGTGACGGGGGGTGCAGAGCTGGGGTACGGGTGCAAGGCCAGTCG
GAGCACCCCCGTGGACGCCCCCGATATCCCTTCCTGATTTCTCTCATTTCTACTTGGGGCCCCCTTCCTAGGACTCTCCCACCCCAAACT
CCAACCTGTATCAGATGCAGCCCCCAAGCCCTTAGACTCTAAGCCCAGTTAGCAAGGTGCCGGGTCACCCTGCAGGTTCCCATAAAAACG

>74974_74974_5_RNF213-HSD17B14_RNF213_chr17_78286967_ENST00000508628_HSD17B14_chr19_49318398_ENST00000263278_length(amino acids)=1133AA_BP=986
MECPSCQHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGGPCLFPGSDSWQENPEEPCSKASWTVQEGAT
SEVLVDAAVDLISDEWEAANAIPSKRRKQDAAPLEAASVPSADCEQSKKKKRKKKKKGNKSASSELASLPLSPASPCHLTLLSNPWPQDT
ALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALGEAGVATGSEAQSSPQFQDHTEGEDQDASIPSGGRGLSQEGT
GPPTSAGEGHSRTEDAAQELLLPESKGGSSEPGTELQTTEQQAGASASMAVDAVAEPANAVKGAGKEMKEKTQRMKQPPATTPPFKTHCQ
EAETKTKDEMAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKNQEADVQEVKASTLSPGGGVTVFFHAIISLHFPFNPDLHKVF
IRGGEEFGESKWDSNICELHYTRDLGHDRVLVEGIVCISKKHLDKYIPYKYVIYNGESFEYEFIYKHQQKKGEYVNRCLFIKSSLLGSGD
WHQYYDIVYMKPHGRLQKVMNHITDGPRKDLVKGKQIAAALMLDSTFSILQTWDTINLNSFFTQFEQFCFVLQQPMIYEGQAQLWTDLQY
REKEVKRYLWQHLKKHVVPLPDGKSTDFLPVDCPVRSKLKTGLIVLFVVEKIELLLEGSLDWLCHLLTSDASSPDEFHRDLSHILGIPQS
WRLYLVNLCQRCMDTRTYTWLGALPVLHCCMELAPRHKDAWRQPEDTWAALEGLSFSPFREQMLDTSSLLQFMREKQHLLSIDEPLFRSW
FSLLPLSHLVMYMENFIEHLGRFPAHILDCLSGIYYRLPGLEQVLNTQDVQDVQNVQNILEMLLRLLDTYRDKIPEEALSPSYLTVCLKL
HEAICSSTKLLKFYELPALSAEIVCRMIRLLSLVDSAGQRDETGNNSVQTVFQGTLAATKRWLREVFTKNMLTSSGASFTYVKEIELALP
YLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCISPGNIWTPLWEELAALMPDPRATIREGMLAQPLGR

--------------------------------------------------------------
>74974_74974_6_RNF213-HSD17B14_RNF213_chr17_78286967_ENST00000508628_HSD17B14_chr19_49318398_ENST00000599157_length(transcript)=3698nt_BP=3103nt
GACAGCGCGCGGCAGGCGGCGAGCTCGGGGGCCGCAGAAAATGAAACTGAAGCCGTGGTCACGTGACAGGACATGTAGTATATAGCAGGC
TGCCAGCGACTCCTGCTCTTGCTTCTGGATCTGCAGGGCAGTCCCAGCAGGACCCATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGA
GGAAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCCATAGCAGATTCTGAGAACAATAACTCCACAATGGC
GTCGGCCTCGGAGGGTGAAATGGAGTGTGGGCAGGAGCTGAAGGAGGAAGGGGGCCCGTGCTTGTTCCCGGGCTCAGACAGTTGGCAAGA
AAACCCCGAGGAGCCCTGTTCCAAAGCCTCCTGGACCGTCCAAGAAGGAGCTACATCAGAGGTTTTGGTAGATGCTGCTGTAGACCTCAT
ATCCGATGAATGGGAAGCTGCTAATGCCATACCCAGCAAGAGAAGGAAGCAGGATGCAGCCCCGCTTGAGGCCGCCAGCGTGCCTTCTGC
AGACTGTGAGCAGAGCAAAAAGAAGAAAAGGAAGAAGAAAAAGAAGGGGAACAAGTCCGCTTCCTCAGAGCTGGCTTCCTTGCCCCTTTC
TCCTGCCAGCCCCTGTCACCTGACTTTGCTTTCAAACCCGTGGCCTCAGGACACAGCCCTGCCCCACAGCCAAGCCCAGCAGAGTGGCCC
CACTGGCCAGCCGAGCCAGCCCCCAGGCACAGCCACCACGCCACTGGAGGGTGACGGCCTCTCCGCGCCCACCGAGGTTGGCGACAGCCC
CCTGCAGGCCCAGGCTTTGGGAGAGGCAGGAGTGGCCACAGGAAGTGAGGCTCAGAGCAGCCCGCAATTCCAGGACCACACGGAAGGGGA
GGACCAGGACGCTTCCATCCCCTCTGGGGGCAGAGGCCTGTCCCAGGAGGGGACCGGTCCCCCCACCTCTGCTGGTGAAGGCCATTCTAG
GACTGAAGATGCTGCCCAGGAGCTCCTGTTGCCTGAGTCAAAAGGAGGCAGCTCTGAGCCCGGGACAGAACTGCAGACCACCGAGCAACA
GGCAGGGGCCTCAGCCTCTATGGCAGTTGATGCTGTAGCTGAGCCAGCCAATGCAGTTAAAGGGGCCGGGAAGGAAATGAAAGAGAAGAC
CCAGAGAATGAAACAGCCACCAGCAACCACTCCTCCTTTCAAAACACACTGCCAGGAAGCTGAGACCAAGACCAAGGACGAGATGGCTGC
TGCTGAAGAAAAAGTCGGTAAGAATGAACAAGGGGAGCCTGAAGACCTCAAGAAGCCAGAGGGGAAGAACAGAAGTGCAGCTGCTGTGAA
AAACGAGAAGGAGCAAAAAAACCAGGAAGCAGATGTCCAGGAAGTGAAGGCAAGCACGCTGAGCCCGGGTGGAGGAGTCACCGTGTTCTT
CCACGCCATCATCTCTCTTCATTTCCCATTCAATCCTGACCTCCATAAAGTCTTCATCAGAGGAGGAGAAGAATTTGGGGAGTCAAAATG
GGACAGCAATATCTGTGAGCTGCACTACACCAGAGACTTGGGTCATGACCGCGTTCTTGTTGAAGGCATTGTCTGCATTTCCAAGAAGCA
CCTAGATAAATACATTCCTTACAAGTACGTCATTTATAATGGGGAATCTTTTGAGTATGAGTTCATTTACAAGCACCAGCAGAAGAAGGG
CGAGTACGTCAACCGCTGTCTGTTCATAAAATCTTCACTTCTGGGCTCAGGAGACTGGCATCAGTACTATGACATAGTTTATATGAAGCC
TCATGGGAGACTCCAGAAAGTCATGAACCACATCACAGACGGGCCGAGGAAGGACCTGGTGAAGGGGAAGCAGATTGCCGCTGCGCTCAT
GCTGGACAGCACCTTCAGCATCCTGCAGACCTGGGACACCATCAACCTGAACAGCTTCTTCACCCAGTTCGAGCAGTTTTGCTTTGTCCT
GCAACAGCCTATGATTTATGAAGGACAGGCACAGCTGTGGACCGATTTGCAGTACAGGGAGAAAGAGGTGAAGAGATACCTGTGGCAACA
TCTGAAAAAACACGTGGTACCATTGCCGGACGGAAAAAGCACGGACTTTTTGCCTGTGGACTGCCCAGTGAGGAGTAAACTGAAAACAGG
CCTGATTGTCCTTTTTGTAGTGGAAAAAATTGAGCTTTTATTAGAAGGCAGCCTGGACTGGTTGTGTCACCTCCTAACCTCAGATGCCAG
CTCACCAGATGAGTTTCACCGTGACCTAAGCCACATCCTTGGGATACCTCAGAGCTGGCGGCTGTACCTGGTGAACCTGTGCCAAAGATG
CATGGACACAAGGACGTACACCTGGCTGGGCGCCCTGCCTGTCCTGCACTGCTGTATGGAGCTGGCCCCGCGGCACAAGGATGCCTGGAG
ACAGCCTGAGGACACCTGGGCCGCTCTGGAGGGACTCTCCTTCTCACCGTTCCGGGAACAAATGCTAGATACGAGTTCCCTACTTCAGTT
TATGAGAGAGAAGCAGCATTTGCTGAGCATAGACGAGCCTCTCTTCCGGTCCTGGTTTAGTCTGCTACCTCTGAGTCACCTGGTTATGTA
TATGGAAAACTTCATTGAGCACCTGGGTCGTTTTCCTGCTCATATCCTGGACTGTCTTTCAGGGATTTACTACCGGCTTCCGGGACTTGA
GCAAGTCTTGAATACGCAGGATGTTCAGGATGTTCAGAACGTTCAGAACATTTTAGAAATGCTGTTGCGACTCCTGGACACTTACCGGGA
CAAGATTCCCGAGGAGGCCTTGTCACCATCCTACCTGACTGTGTGTCTGAAACTGCATGAAGCCATCTGCAGCAGCACAAAGCTACTTAA
GTTTTACGAGCTGCCAGCCTTATCTGCCGAGATTGTCTGCAGAATGATTAGACTTCTATCTCTGGTGGATTCTGCAGGACAGAGAGATGA
AACTGGAAATAATTCAGTCCAAACAGTCTTCCAAGGGACCCTTGCTGCTACGAAAAGGTGGCTCCGAGAAGTTTTTACAAAGAACATGCT
CACATCTTCAGGTGCCTCATTCACATACGTCAAGGAAATTGAGCTCGCCCTCCCCTACCTGCGGAAGAGTCAAGGGAATGTCATCAACAT
CTCCAGCCTGGTGGGGGCAATCGGCCAGGCCCAGGCAGTTCCCTATGTGGCCACCAAGGGGGCAGTAACAGCCATGACCAAAGCTTTGGC
CCTGGATGAAAGTCCATATGGTGTCCGAGTCAACTGTATCTCCCCAGGAAACATCTGGACCCCGCTGTGGGAGGAGCTGGCAGCCTTAAT
GCCAGACCCTAGGGCCACAATCCGAGAGGGCATGCTGGCCCAGCCACTGGGCCGCATGGGCCAGCCCGCTGAGGTCGGGGCTGCGGCAGT
GTTCCTGGCCTCCGAAGCCAACTTCTGCACGGGCATTGAACTGCTCGTGACGGGGGGTGCAGAGCTGGGGTACGGGTGCAAGGCCAGTCG
GAGCACCCCCGTGGACGCCCCCGATATCCCTTCCTGATTTCTCTCATTTCTACTTGGGGCCCCCTTCCTAGGACTCTCCCACCCCAAACT
CCAACCTGTATCAGATGCAGCCCCCAAGCCCTTAGACTCTAAGCCCAGTTAGCAAGGTGCCGGGTCACCCTGCAGGTTCCCATAAAAACG

>74974_74974_6_RNF213-HSD17B14_RNF213_chr17_78286967_ENST00000508628_HSD17B14_chr19_49318398_ENST00000599157_length(amino acids)=1133AA_BP=986
MECPSCQHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGGPCLFPGSDSWQENPEEPCSKASWTVQEGAT
SEVLVDAAVDLISDEWEAANAIPSKRRKQDAAPLEAASVPSADCEQSKKKKRKKKKKGNKSASSELASLPLSPASPCHLTLLSNPWPQDT
ALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALGEAGVATGSEAQSSPQFQDHTEGEDQDASIPSGGRGLSQEGT
GPPTSAGEGHSRTEDAAQELLLPESKGGSSEPGTELQTTEQQAGASASMAVDAVAEPANAVKGAGKEMKEKTQRMKQPPATTPPFKTHCQ
EAETKTKDEMAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKNQEADVQEVKASTLSPGGGVTVFFHAIISLHFPFNPDLHKVF
IRGGEEFGESKWDSNICELHYTRDLGHDRVLVEGIVCISKKHLDKYIPYKYVIYNGESFEYEFIYKHQQKKGEYVNRCLFIKSSLLGSGD
WHQYYDIVYMKPHGRLQKVMNHITDGPRKDLVKGKQIAAALMLDSTFSILQTWDTINLNSFFTQFEQFCFVLQQPMIYEGQAQLWTDLQY
REKEVKRYLWQHLKKHVVPLPDGKSTDFLPVDCPVRSKLKTGLIVLFVVEKIELLLEGSLDWLCHLLTSDASSPDEFHRDLSHILGIPQS
WRLYLVNLCQRCMDTRTYTWLGALPVLHCCMELAPRHKDAWRQPEDTWAALEGLSFSPFREQMLDTSSLLQFMREKQHLLSIDEPLFRSW
FSLLPLSHLVMYMENFIEHLGRFPAHILDCLSGIYYRLPGLEQVLNTQDVQDVQNVQNILEMLLRLLDTYRDKIPEEALSPSYLTVCLKL
HEAICSSTKLLKFYELPALSAEIVCRMIRLLSLVDSAGQRDETGNNSVQTVFQGTLAATKRWLREVFTKNMLTSSGASFTYVKEIELALP
YLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCISPGNIWTPLWEELAALMPDPRATIREGMLAQPLGR

--------------------------------------------------------------
>74974_74974_7_RNF213-HSD17B14_RNF213_chr17_78286967_ENST00000582970_HSD17B14_chr19_49318398_ENST00000263278_length(transcript)=3556nt_BP=2954nt
CAGCGCGCGGCAGGCGGCGAGCTCGGGGGCCGCAGAAAATGAAACTGAAGCCGTGGTCACGTGACAGGACATGTAGTATATAGCAGGCTG
CCAGCGACTCCTGCTCTTGCTTCTGGATCTGCAGGGCAGTCCCAGCAGGACCCATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGAGG
AAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCCATAGCAGATTCTGAGAACAATAACTCCACAATGGCGT
CGGCCTCGGAGGGTGAAATGGAGTGTGGGCAGGAGCTGAAGGAGGAAGGGGGCCCGTGCTTGTTCCCGGGCTCAGACAGTTGGCAAGAAA
ACCCCGAGGAGCCCTGTTCCAAAGCCTCCTGGACCGTCCAAGAAAGCAAAAAGAAGAAAAGGAAGAAGAAAAAGAAGGGGAACAAGTCCG
CTTCCTCAGAGCTGGCTTCCTTGCCCCTTTCTCCTGCCAGCCCCTGTCACCTGACTTTGCTTTCAAACCCGTGGCCTCAGGACACAGCCC
TGCCCCACAGCCAAGCCCAGCAGAGTGGCCCCACTGGCCAGCCGAGCCAGCCCCCAGGCACAGCCACCACGCCACTGGAGGGTGACGGCC
TCTCCGCGCCCACCGAGGTTGGCGACAGCCCCCTGCAGGCCCAGGCTTTGGGAGAGGCAGGAGTGGCCACAGGAAGTGAGGCTCAGAGCA
GCCCGCAATTCCAGGACCACACGGAAGGGGAGGACCAGGACGCTTCCATCCCCTCTGGGGGCAGAGGCCTGTCCCAGGAGGGGACCGGTC
CCCCCACCTCTGCTGGTGAAGGCCATTCTAGGACTGAAGATGCTGCCCAGGAGCTCCTGTTGCCTGAGTCAAAAGGAGGCAGCTCTGAGC
CCGGGACAGAACTGCAGACCACCGAGCAACAGGCAGGGGCCTCAGCCTCTATGGCAGTTGATGCTGTAGCTGAGCCAGCCAATGCAGTTA
AAGGGGCCGGGAAGGAAATGAAAGAGAAGACCCAGAGAATGAAACAGCCACCAGCAACCACTCCTCCTTTCAAAACACACTGCCAGGAAG
CTGAGACCAAGACCAAGGACGAGATGGCTGCTGCTGAAGAAAAAGTCGGTAAGAATGAACAAGGGGAGCCTGAAGACCTCAAGAAGCCAG
AGGGGAAGAACAGAAGTGCAGCTGCTGTGAAAAACGAGAAGGAGCAAAAAAACCAGGAAGCAGATGTCCAGGAAGTGAAGGCAAGCACGC
TGAGCCCGGGTGGAGGAGTCACCGTGTTCTTCCACGCCATCATCTCTCTTCATTTCCCATTCAATCCTGACCTCCATAAAGTCTTCATCA
GAGGAGGAGAAGAATTTGGGGAGTCAAAATGGGACAGCAATATCTGTGAGCTGCACTACACCAGAGACTTGGGTCATGACCGCGTTCTTG
TTGAAGGCATTGTCTGCATTTCCAAGAAGCACCTAGATAAATACATTCCTTACAAGTACGTCATTTATAATGGGGAATCTTTTGAGTATG
AGTTCATTTACAAGCACCAGCAGAAGAAGGGCGAGTACGTCAACCGCTGTCTGTTCATAAAATCTTCACTTCTGGGCTCAGGAGACTGGC
ATCAGTACTATGACATAGTTTATATGAAGCCTCATGGGAGACTCCAGAAAGTCATGAACCACATCACAGACGGGCCGAGGAAGGACCTGG
TGAAGGGGAAGCAGATTGCCGCTGCGCTCATGCTGGACAGCACCTTCAGCATCCTGCAGACCTGGGACACCATCAACCTGAACAGCTTCT
TCACCCAGTTCGAGCAGTTTTGCTTTGTCCTGCAACAGCCTATGATTTATGAAGGACAGGCACAGCTGTGGACCGATTTGCAGTACAGGG
AGAAAGAGGTGAAGAGATACCTGTGGCAACATCTGAAAAAACACGTGGTACCATTGCCGGACGGAAAAAGCACGGACTTTTTGCCTGTGG
ACTGCCCAGTGAGGAGTAAACTGAAAACAGGCCTGATTGTCCTTTTTGTAGTGGAAAAAATTGAGCTTTTATTAGAAGGCAGCCTGGACT
GGTTGTGTCACCTCCTAACCTCAGATGCCAGCTCACCAGATGAGTTTCACCGTGACCTAAGCCACATCCTTGGGATACCTCAGAGCTGGC
GGCTGTACCTGGTGAACCTGTGCCAAAGATGCATGGACACAAGGACGTACACCTGGCTGGGCGCCCTGCCTGTCCTGCACTGCTGTATGG
AGCTGGCCCCGCGGCACAAGGATGCCTGGAGACAGCCTGAGGACACCTGGGCCGCTCTGGAGGGACTCTCCTTCTCACCGTTCCGGGAAC
AAATGCTAGATACGAGTTCCCTACTTCAGTTTATGAGAGAGAAGCAGCATTTGCTGAGCATAGACGAGCCTCTCTTCCGGTCCTGGTTTA
GTCTGCTACCTCTGAGTCACCTGGTTATGTATATGGAAAACTTCATTGAGCACCTGGGTCGTTTTCCTGCTCATATCCTGGACTGTCTTT
CAGGGATTTACTACCGGCTTCCGGGACTTGAGCAAGTCTTGAATACGCAGGATGTTCAGGATGTTCAGAACGTTCAGAACATTTTAGAAA
TGCTGTTGCGACTCCTGGACACTTACCGGGACAAGATTCCCGAGGAGGCCTTGTCACCATCCTACCTGACTGTGTGTCTGAAACTGCATG
AAGCCATCTGCAGCAGCACAAAGCTACTTAAGTTTTACGAGCTGCCAGCCTTATCTGCCGAGATTGTCTGCAGAATGATTAGACTTCTAT
CTCTGGTGGATTCTGCAGGACAGAGAGATGAAACTGGAAATAATTCAGTCCAAACAGTCTTCCAAGGGACCCTTGCTGCTACGAAAAGGT
GGCTCCGAGAAGTTTTTACAAAGAACATGCTCACATCTTCAGGTGCCTCATTCACATACGTCAAGGAAATTGAGCTCGCCCTCCCCTACC
TGCGGAAGAGTCAAGGGAATGTCATCAACATCTCCAGCCTGGTGGGGGCAATCGGCCAGGCCCAGGCAGTTCCCTATGTGGCCACCAAGG
GGGCAGTAACAGCCATGACCAAAGCTTTGGCCCTGGATGAAAGTCCATATGGTGTCCGAGTCAACTGTATCTCCCCAGGAAACATCTGGA
CCCCGCTGTGGGAGGAGCTGGCAGCCTTAATGCCAGACCCTAGGGCCACAATCCGAGAGGGCATGCTGGCCCAGCCACTGGGCCGCATGG
GCCAGCCCGCTGAGGTCGGGGCTGCGGCAGTGTTCCTGGCCTCCGAAGCCAACTTCTGCACGGGCATTGAACTGCTCGTGACGGGGGGTG
CAGAGCTGGGGTACGGGTGCAAGGCCAGTCGGAGCACCCCCGTGGACGCCCCCGATATCCCTTCCTGATTTCTCTCATTTCTACTTGGGG
CCCCCTTCCTAGGACTCTCCCACCCCAAACTCCAACCTGTATCAGATGCAGCCCCCAAGCCCTTAGACTCTAAGCCCAGTTAGCAAGGTG

>74974_74974_7_RNF213-HSD17B14_RNF213_chr17_78286967_ENST00000582970_HSD17B14_chr19_49318398_ENST00000263278_length(amino acids)=1084AA_BP=937
MECPSCQHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGGPCLFPGSDSWQENPEEPCSKASWTVQESKK
KKRKKKKKGNKSASSELASLPLSPASPCHLTLLSNPWPQDTALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALG
EAGVATGSEAQSSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQELLLPESKGGSSEPGTELQTTEQQAGASASM
AVDAVAEPANAVKGAGKEMKEKTQRMKQPPATTPPFKTHCQEAETKTKDEMAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKN
QEADVQEVKASTLSPGGGVTVFFHAIISLHFPFNPDLHKVFIRGGEEFGESKWDSNICELHYTRDLGHDRVLVEGIVCISKKHLDKYIPY
KYVIYNGESFEYEFIYKHQQKKGEYVNRCLFIKSSLLGSGDWHQYYDIVYMKPHGRLQKVMNHITDGPRKDLVKGKQIAAALMLDSTFSI
LQTWDTINLNSFFTQFEQFCFVLQQPMIYEGQAQLWTDLQYREKEVKRYLWQHLKKHVVPLPDGKSTDFLPVDCPVRSKLKTGLIVLFVV
EKIELLLEGSLDWLCHLLTSDASSPDEFHRDLSHILGIPQSWRLYLVNLCQRCMDTRTYTWLGALPVLHCCMELAPRHKDAWRQPEDTWA
ALEGLSFSPFREQMLDTSSLLQFMREKQHLLSIDEPLFRSWFSLLPLSHLVMYMENFIEHLGRFPAHILDCLSGIYYRLPGLEQVLNTQD
VQDVQNVQNILEMLLRLLDTYRDKIPEEALSPSYLTVCLKLHEAICSSTKLLKFYELPALSAEIVCRMIRLLSLVDSAGQRDETGNNSVQ
TVFQGTLAATKRWLREVFTKNMLTSSGASFTYVKEIELALPYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYG
VRVNCISPGNIWTPLWEELAALMPDPRATIREGMLAQPLGRMGQPAEVGAAAVFLASEANFCTGIELLVTGGAELGYGCKASRSTPVDAP

--------------------------------------------------------------
>74974_74974_8_RNF213-HSD17B14_RNF213_chr17_78286967_ENST00000582970_HSD17B14_chr19_49318398_ENST00000599157_length(transcript)=3549nt_BP=2954nt
CAGCGCGCGGCAGGCGGCGAGCTCGGGGGCCGCAGAAAATGAAACTGAAGCCGTGGTCACGTGACAGGACATGTAGTATATAGCAGGCTG
CCAGCGACTCCTGCTCTTGCTTCTGGATCTGCAGGGCAGTCCCAGCAGGACCCATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGAGG
AAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCCATAGCAGATTCTGAGAACAATAACTCCACAATGGCGT
CGGCCTCGGAGGGTGAAATGGAGTGTGGGCAGGAGCTGAAGGAGGAAGGGGGCCCGTGCTTGTTCCCGGGCTCAGACAGTTGGCAAGAAA
ACCCCGAGGAGCCCTGTTCCAAAGCCTCCTGGACCGTCCAAGAAAGCAAAAAGAAGAAAAGGAAGAAGAAAAAGAAGGGGAACAAGTCCG
CTTCCTCAGAGCTGGCTTCCTTGCCCCTTTCTCCTGCCAGCCCCTGTCACCTGACTTTGCTTTCAAACCCGTGGCCTCAGGACACAGCCC
TGCCCCACAGCCAAGCCCAGCAGAGTGGCCCCACTGGCCAGCCGAGCCAGCCCCCAGGCACAGCCACCACGCCACTGGAGGGTGACGGCC
TCTCCGCGCCCACCGAGGTTGGCGACAGCCCCCTGCAGGCCCAGGCTTTGGGAGAGGCAGGAGTGGCCACAGGAAGTGAGGCTCAGAGCA
GCCCGCAATTCCAGGACCACACGGAAGGGGAGGACCAGGACGCTTCCATCCCCTCTGGGGGCAGAGGCCTGTCCCAGGAGGGGACCGGTC
CCCCCACCTCTGCTGGTGAAGGCCATTCTAGGACTGAAGATGCTGCCCAGGAGCTCCTGTTGCCTGAGTCAAAAGGAGGCAGCTCTGAGC
CCGGGACAGAACTGCAGACCACCGAGCAACAGGCAGGGGCCTCAGCCTCTATGGCAGTTGATGCTGTAGCTGAGCCAGCCAATGCAGTTA
AAGGGGCCGGGAAGGAAATGAAAGAGAAGACCCAGAGAATGAAACAGCCACCAGCAACCACTCCTCCTTTCAAAACACACTGCCAGGAAG
CTGAGACCAAGACCAAGGACGAGATGGCTGCTGCTGAAGAAAAAGTCGGTAAGAATGAACAAGGGGAGCCTGAAGACCTCAAGAAGCCAG
AGGGGAAGAACAGAAGTGCAGCTGCTGTGAAAAACGAGAAGGAGCAAAAAAACCAGGAAGCAGATGTCCAGGAAGTGAAGGCAAGCACGC
TGAGCCCGGGTGGAGGAGTCACCGTGTTCTTCCACGCCATCATCTCTCTTCATTTCCCATTCAATCCTGACCTCCATAAAGTCTTCATCA
GAGGAGGAGAAGAATTTGGGGAGTCAAAATGGGACAGCAATATCTGTGAGCTGCACTACACCAGAGACTTGGGTCATGACCGCGTTCTTG
TTGAAGGCATTGTCTGCATTTCCAAGAAGCACCTAGATAAATACATTCCTTACAAGTACGTCATTTATAATGGGGAATCTTTTGAGTATG
AGTTCATTTACAAGCACCAGCAGAAGAAGGGCGAGTACGTCAACCGCTGTCTGTTCATAAAATCTTCACTTCTGGGCTCAGGAGACTGGC
ATCAGTACTATGACATAGTTTATATGAAGCCTCATGGGAGACTCCAGAAAGTCATGAACCACATCACAGACGGGCCGAGGAAGGACCTGG
TGAAGGGGAAGCAGATTGCCGCTGCGCTCATGCTGGACAGCACCTTCAGCATCCTGCAGACCTGGGACACCATCAACCTGAACAGCTTCT
TCACCCAGTTCGAGCAGTTTTGCTTTGTCCTGCAACAGCCTATGATTTATGAAGGACAGGCACAGCTGTGGACCGATTTGCAGTACAGGG
AGAAAGAGGTGAAGAGATACCTGTGGCAACATCTGAAAAAACACGTGGTACCATTGCCGGACGGAAAAAGCACGGACTTTTTGCCTGTGG
ACTGCCCAGTGAGGAGTAAACTGAAAACAGGCCTGATTGTCCTTTTTGTAGTGGAAAAAATTGAGCTTTTATTAGAAGGCAGCCTGGACT
GGTTGTGTCACCTCCTAACCTCAGATGCCAGCTCACCAGATGAGTTTCACCGTGACCTAAGCCACATCCTTGGGATACCTCAGAGCTGGC
GGCTGTACCTGGTGAACCTGTGCCAAAGATGCATGGACACAAGGACGTACACCTGGCTGGGCGCCCTGCCTGTCCTGCACTGCTGTATGG
AGCTGGCCCCGCGGCACAAGGATGCCTGGAGACAGCCTGAGGACACCTGGGCCGCTCTGGAGGGACTCTCCTTCTCACCGTTCCGGGAAC
AAATGCTAGATACGAGTTCCCTACTTCAGTTTATGAGAGAGAAGCAGCATTTGCTGAGCATAGACGAGCCTCTCTTCCGGTCCTGGTTTA
GTCTGCTACCTCTGAGTCACCTGGTTATGTATATGGAAAACTTCATTGAGCACCTGGGTCGTTTTCCTGCTCATATCCTGGACTGTCTTT
CAGGGATTTACTACCGGCTTCCGGGACTTGAGCAAGTCTTGAATACGCAGGATGTTCAGGATGTTCAGAACGTTCAGAACATTTTAGAAA
TGCTGTTGCGACTCCTGGACACTTACCGGGACAAGATTCCCGAGGAGGCCTTGTCACCATCCTACCTGACTGTGTGTCTGAAACTGCATG
AAGCCATCTGCAGCAGCACAAAGCTACTTAAGTTTTACGAGCTGCCAGCCTTATCTGCCGAGATTGTCTGCAGAATGATTAGACTTCTAT
CTCTGGTGGATTCTGCAGGACAGAGAGATGAAACTGGAAATAATTCAGTCCAAACAGTCTTCCAAGGGACCCTTGCTGCTACGAAAAGGT
GGCTCCGAGAAGTTTTTACAAAGAACATGCTCACATCTTCAGGTGCCTCATTCACATACGTCAAGGAAATTGAGCTCGCCCTCCCCTACC
TGCGGAAGAGTCAAGGGAATGTCATCAACATCTCCAGCCTGGTGGGGGCAATCGGCCAGGCCCAGGCAGTTCCCTATGTGGCCACCAAGG
GGGCAGTAACAGCCATGACCAAAGCTTTGGCCCTGGATGAAAGTCCATATGGTGTCCGAGTCAACTGTATCTCCCCAGGAAACATCTGGA
CCCCGCTGTGGGAGGAGCTGGCAGCCTTAATGCCAGACCCTAGGGCCACAATCCGAGAGGGCATGCTGGCCCAGCCACTGGGCCGCATGG
GCCAGCCCGCTGAGGTCGGGGCTGCGGCAGTGTTCCTGGCCTCCGAAGCCAACTTCTGCACGGGCATTGAACTGCTCGTGACGGGGGGTG
CAGAGCTGGGGTACGGGTGCAAGGCCAGTCGGAGCACCCCCGTGGACGCCCCCGATATCCCTTCCTGATTTCTCTCATTTCTACTTGGGG
CCCCCTTCCTAGGACTCTCCCACCCCAAACTCCAACCTGTATCAGATGCAGCCCCCAAGCCCTTAGACTCTAAGCCCAGTTAGCAAGGTG

>74974_74974_8_RNF213-HSD17B14_RNF213_chr17_78286967_ENST00000582970_HSD17B14_chr19_49318398_ENST00000599157_length(amino acids)=1084AA_BP=937
MECPSCQHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGGPCLFPGSDSWQENPEEPCSKASWTVQESKK
KKRKKKKKGNKSASSELASLPLSPASPCHLTLLSNPWPQDTALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALG
EAGVATGSEAQSSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQELLLPESKGGSSEPGTELQTTEQQAGASASM
AVDAVAEPANAVKGAGKEMKEKTQRMKQPPATTPPFKTHCQEAETKTKDEMAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKN
QEADVQEVKASTLSPGGGVTVFFHAIISLHFPFNPDLHKVFIRGGEEFGESKWDSNICELHYTRDLGHDRVLVEGIVCISKKHLDKYIPY
KYVIYNGESFEYEFIYKHQQKKGEYVNRCLFIKSSLLGSGDWHQYYDIVYMKPHGRLQKVMNHITDGPRKDLVKGKQIAAALMLDSTFSI
LQTWDTINLNSFFTQFEQFCFVLQQPMIYEGQAQLWTDLQYREKEVKRYLWQHLKKHVVPLPDGKSTDFLPVDCPVRSKLKTGLIVLFVV
EKIELLLEGSLDWLCHLLTSDASSPDEFHRDLSHILGIPQSWRLYLVNLCQRCMDTRTYTWLGALPVLHCCMELAPRHKDAWRQPEDTWA
ALEGLSFSPFREQMLDTSSLLQFMREKQHLLSIDEPLFRSWFSLLPLSHLVMYMENFIEHLGRFPAHILDCLSGIYYRLPGLEQVLNTQD
VQDVQNVQNILEMLLRLLDTYRDKIPEEALSPSYLTVCLKLHEAICSSTKLLKFYELPALSAEIVCRMIRLLSLVDSAGQRDETGNNSVQ
TVFQGTLAATKRWLREVFTKNMLTSSGASFTYVKEIELALPYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYG
VRVNCISPGNIWTPLWEELAALMPDPRATIREGMLAQPLGRMGQPAEVGAAAVFLASEANFCTGIELLVTGGAELGYGCKASRSTPVDAP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RNF213-HSD17B14


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RNF213-HSD17B14


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RNF213-HSD17B14


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource