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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RNF213-TBCD (FusionGDB2 ID:74993)

Fusion Gene Summary for RNF213-TBCD

check button Fusion gene summary
Fusion gene informationFusion gene name: RNF213-TBCD
Fusion gene ID: 74993
HgeneTgene
Gene symbol

RNF213

TBCD

Gene ID

57674

6904

Gene namering finger protein 213tubulin folding cofactor D
SynonymsALO17|C17orf27|KIAA1618|MYMY2|MYSTR|NET57PEBAT|SSD-1|tfcD
Cytomap

17q25.3

17q25.3

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase RNF213ALK lymphoma oligomerization partner on chromosome 17RING-type E3 ubiquitin transferase RNF213mysterintubulin-specific chaperone Dbeta-tubulin cofactor D
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000336301, ENST00000508628, 
ENST00000582970, ENST00000319921, 
ENST00000456466, ENST00000427003, 
ENST00000397466, ENST00000539345, 
ENST00000576691, ENST00000355528, 
Fusion gene scores* DoF score34 X 32 X 16=1740819 X 22 X 13=5434
# samples 4128
** MAII scorelog2(41/17408*10)=-5.40798274174489
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(28/5434*10)=-4.27851583327701
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RNF213 [Title/Abstract] AND TBCD [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRNF213(78237577)-TBCD(80828100), # samples:2
Anticipated loss of major functional domain due to fusion event.RNF213-TBCD seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
RNF213-TBCD seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
RNF213-TBCD seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRNF213

GO:0016567

protein ubiquitination

21799892

HgeneRNF213

GO:0051260

protein homooligomerization

24658080|26126547

HgeneRNF213

GO:0051865

protein autoubiquitination

21799892

TgeneTBCD

GO:0006457

protein folding

20740604

TgeneTBCD

GO:0007021

tubulin complex assembly

28158450

TgeneTBCD

GO:0007023

post-chaperonin tubulin folding pathway

11847227

TgeneTBCD

GO:0031115

negative regulation of microtubule polymerization

10831612|20740604


check buttonFusion gene breakpoints across RNF213 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TBCD (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-XV-AAZV-01ARNF213chr17

78237577

-TBCDchr17

80828100

+
ChimerDB4SKCMTCGA-XV-AAZV-01ARNF213chr17

78237577

+TBCDchr17

80828100

+
ChimerDB4SKCMTCGA-XV-AAZVRNF213chr17

78237577

+TBCDchr17

80828099

+
ChimerDB4STADTCGA-D7-6822-01ARNF213chr17

78319369

+TBCDchr17

80714041

+


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Fusion Gene ORF analysis for RNF213-TBCD

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000336301ENST00000397466RNF213chr17

78319369

+TBCDchr17

80714041

+
5CDS-5UTRENST00000336301ENST00000539345RNF213chr17

78319369

+TBCDchr17

80714041

+
5CDS-5UTRENST00000508628ENST00000397466RNF213chr17

78319369

+TBCDchr17

80714041

+
5CDS-5UTRENST00000508628ENST00000539345RNF213chr17

78319369

+TBCDchr17

80714041

+
5CDS-5UTRENST00000582970ENST00000397466RNF213chr17

78319369

+TBCDchr17

80714041

+
5CDS-5UTRENST00000582970ENST00000539345RNF213chr17

78319369

+TBCDchr17

80714041

+
5CDS-intronENST00000319921ENST00000576691RNF213chr17

78237577

+TBCDchr17

80828100

+
5CDS-intronENST00000319921ENST00000576691RNF213chr17

78237577

+TBCDchr17

80828099

+
5CDS-intronENST00000336301ENST00000576691RNF213chr17

78319369

+TBCDchr17

80714041

+
5CDS-intronENST00000456466ENST00000576691RNF213chr17

78237577

+TBCDchr17

80828100

+
5CDS-intronENST00000456466ENST00000576691RNF213chr17

78237577

+TBCDchr17

80828099

+
5CDS-intronENST00000508628ENST00000576691RNF213chr17

78237577

+TBCDchr17

80828100

+
5CDS-intronENST00000508628ENST00000576691RNF213chr17

78237577

+TBCDchr17

80828099

+
5CDS-intronENST00000508628ENST00000576691RNF213chr17

78319369

+TBCDchr17

80714041

+
5CDS-intronENST00000582970ENST00000576691RNF213chr17

78237577

+TBCDchr17

80828100

+
5CDS-intronENST00000582970ENST00000576691RNF213chr17

78237577

+TBCDchr17

80828099

+
5CDS-intronENST00000582970ENST00000576691RNF213chr17

78319369

+TBCDchr17

80714041

+
Frame-shiftENST00000336301ENST00000355528RNF213chr17

78319369

+TBCDchr17

80714041

+
Frame-shiftENST00000508628ENST00000355528RNF213chr17

78319369

+TBCDchr17

80714041

+
Frame-shiftENST00000582970ENST00000355528RNF213chr17

78319369

+TBCDchr17

80714041

+
In-frameENST00000319921ENST00000355528RNF213chr17

78237577

+TBCDchr17

80828100

+
In-frameENST00000319921ENST00000355528RNF213chr17

78237577

+TBCDchr17

80828099

+
In-frameENST00000319921ENST00000397466RNF213chr17

78237577

+TBCDchr17

80828100

+
In-frameENST00000319921ENST00000397466RNF213chr17

78237577

+TBCDchr17

80828099

+
In-frameENST00000319921ENST00000539345RNF213chr17

78237577

+TBCDchr17

80828100

+
In-frameENST00000319921ENST00000539345RNF213chr17

78237577

+TBCDchr17

80828099

+
In-frameENST00000456466ENST00000355528RNF213chr17

78237577

+TBCDchr17

80828100

+
In-frameENST00000456466ENST00000355528RNF213chr17

78237577

+TBCDchr17

80828099

+
In-frameENST00000456466ENST00000397466RNF213chr17

78237577

+TBCDchr17

80828100

+
In-frameENST00000456466ENST00000397466RNF213chr17

78237577

+TBCDchr17

80828099

+
In-frameENST00000456466ENST00000539345RNF213chr17

78237577

+TBCDchr17

80828100

+
In-frameENST00000456466ENST00000539345RNF213chr17

78237577

+TBCDchr17

80828099

+
In-frameENST00000508628ENST00000355528RNF213chr17

78237577

+TBCDchr17

80828100

+
In-frameENST00000508628ENST00000355528RNF213chr17

78237577

+TBCDchr17

80828099

+
In-frameENST00000508628ENST00000397466RNF213chr17

78237577

+TBCDchr17

80828100

+
In-frameENST00000508628ENST00000397466RNF213chr17

78237577

+TBCDchr17

80828099

+
In-frameENST00000508628ENST00000539345RNF213chr17

78237577

+TBCDchr17

80828100

+
In-frameENST00000508628ENST00000539345RNF213chr17

78237577

+TBCDchr17

80828099

+
In-frameENST00000582970ENST00000355528RNF213chr17

78237577

+TBCDchr17

80828100

+
In-frameENST00000582970ENST00000355528RNF213chr17

78237577

+TBCDchr17

80828099

+
In-frameENST00000582970ENST00000397466RNF213chr17

78237577

+TBCDchr17

80828100

+
In-frameENST00000582970ENST00000397466RNF213chr17

78237577

+TBCDchr17

80828099

+
In-frameENST00000582970ENST00000539345RNF213chr17

78237577

+TBCDchr17

80828100

+
In-frameENST00000582970ENST00000539345RNF213chr17

78237577

+TBCDchr17

80828099

+
intron-3CDSENST00000319921ENST00000355528RNF213chr17

78319369

+TBCDchr17

80714041

+
intron-3CDSENST00000336301ENST00000355528RNF213chr17

78237577

+TBCDchr17

80828100

+
intron-3CDSENST00000336301ENST00000355528RNF213chr17

78237577

+TBCDchr17

80828099

+
intron-3CDSENST00000336301ENST00000397466RNF213chr17

78237577

+TBCDchr17

80828100

+
intron-3CDSENST00000336301ENST00000397466RNF213chr17

78237577

+TBCDchr17

80828099

+
intron-3CDSENST00000336301ENST00000539345RNF213chr17

78237577

+TBCDchr17

80828100

+
intron-3CDSENST00000336301ENST00000539345RNF213chr17

78237577

+TBCDchr17

80828099

+
intron-3CDSENST00000427003ENST00000355528RNF213chr17

78237577

+TBCDchr17

80828100

+
intron-3CDSENST00000427003ENST00000355528RNF213chr17

78237577

+TBCDchr17

80828099

+
intron-3CDSENST00000427003ENST00000355528RNF213chr17

78319369

+TBCDchr17

80714041

+
intron-3CDSENST00000427003ENST00000397466RNF213chr17

78237577

+TBCDchr17

80828100

+
intron-3CDSENST00000427003ENST00000397466RNF213chr17

78237577

+TBCDchr17

80828099

+
intron-3CDSENST00000427003ENST00000539345RNF213chr17

78237577

+TBCDchr17

80828100

+
intron-3CDSENST00000427003ENST00000539345RNF213chr17

78237577

+TBCDchr17

80828099

+
intron-3CDSENST00000456466ENST00000355528RNF213chr17

78319369

+TBCDchr17

80714041

+
intron-5UTRENST00000319921ENST00000397466RNF213chr17

78319369

+TBCDchr17

80714041

+
intron-5UTRENST00000319921ENST00000539345RNF213chr17

78319369

+TBCDchr17

80714041

+
intron-5UTRENST00000427003ENST00000397466RNF213chr17

78319369

+TBCDchr17

80714041

+
intron-5UTRENST00000427003ENST00000539345RNF213chr17

78319369

+TBCDchr17

80714041

+
intron-5UTRENST00000456466ENST00000397466RNF213chr17

78319369

+TBCDchr17

80714041

+
intron-5UTRENST00000456466ENST00000539345RNF213chr17

78319369

+TBCDchr17

80714041

+
intron-intronENST00000319921ENST00000576691RNF213chr17

78319369

+TBCDchr17

80714041

+
intron-intronENST00000336301ENST00000576691RNF213chr17

78237577

+TBCDchr17

80828100

+
intron-intronENST00000336301ENST00000576691RNF213chr17

78237577

+TBCDchr17

80828099

+
intron-intronENST00000427003ENST00000576691RNF213chr17

78237577

+TBCDchr17

80828100

+
intron-intronENST00000427003ENST00000576691RNF213chr17

78237577

+TBCDchr17

80828099

+
intron-intronENST00000427003ENST00000576691RNF213chr17

78319369

+TBCDchr17

80714041

+
intron-intronENST00000456466ENST00000576691RNF213chr17

78319369

+TBCDchr17

80714041

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000508628RNF213chr1778237577+ENST00000355528TBCDchr1780828099+28882421452502785
ENST00000508628RNF213chr1778237577+ENST00000397466TBCDchr1780828099+1018242100258314
ENST00000508628RNF213chr1778237577+ENST00000539345TBCDchr1780828099+28632421452616823
ENST00000456466RNF213chr1778237577+ENST00000355528TBCDchr1780828099+28862401432500785
ENST00000456466RNF213chr1778237577+ENST00000397466TBCDchr1780828099+1016240100056314
ENST00000456466RNF213chr1778237577+ENST00000539345TBCDchr1780828099+28612401432614823
ENST00000582970RNF213chr1778237577+ENST00000355528TBCDchr1780828099+28862401432500785
ENST00000582970RNF213chr1778237577+ENST00000397466TBCDchr1780828099+1016240100056314
ENST00000582970RNF213chr1778237577+ENST00000539345TBCDchr1780828099+28612401432614823
ENST00000319921RNF213chr1778237577+ENST00000355528TBCDchr1780828099+28842381412498785
ENST00000319921RNF213chr1778237577+ENST00000397466TBCDchr1780828099+101423899854314
ENST00000319921RNF213chr1778237577+ENST00000539345TBCDchr1780828099+28592381412612823
ENST00000508628RNF213chr1778237577+ENST00000355528TBCDchr1780828100+28882421452502785
ENST00000508628RNF213chr1778237577+ENST00000397466TBCDchr1780828100+1018242100258314
ENST00000508628RNF213chr1778237577+ENST00000539345TBCDchr1780828100+28632421452616823
ENST00000456466RNF213chr1778237577+ENST00000355528TBCDchr1780828100+28862401432500785
ENST00000456466RNF213chr1778237577+ENST00000397466TBCDchr1780828100+1016240100056314
ENST00000456466RNF213chr1778237577+ENST00000539345TBCDchr1780828100+28612401432614823
ENST00000582970RNF213chr1778237577+ENST00000355528TBCDchr1780828100+28862401432500785
ENST00000582970RNF213chr1778237577+ENST00000397466TBCDchr1780828100+1016240100056314
ENST00000582970RNF213chr1778237577+ENST00000539345TBCDchr1780828100+28612401432614823
ENST00000319921RNF213chr1778237577+ENST00000355528TBCDchr1780828100+28842381412498785
ENST00000319921RNF213chr1778237577+ENST00000397466TBCDchr1780828100+101423899854314
ENST00000319921RNF213chr1778237577+ENST00000539345TBCDchr1780828100+28592381412612823

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000508628ENST00000355528RNF213chr1778237577+TBCDchr1780828099+0.0054045570.99459547
ENST00000508628ENST00000397466RNF213chr1778237577+TBCDchr1780828099+0.0165989290.9834011
ENST00000508628ENST00000539345RNF213chr1778237577+TBCDchr1780828099+0.0052083180.9947917
ENST00000456466ENST00000355528RNF213chr1778237577+TBCDchr1780828099+0.0054570070.99454296
ENST00000456466ENST00000397466RNF213chr1778237577+TBCDchr1780828099+0.0165850560.98341495
ENST00000456466ENST00000539345RNF213chr1778237577+TBCDchr1780828099+0.0052618580.99473816
ENST00000582970ENST00000355528RNF213chr1778237577+TBCDchr1780828099+0.0054570070.99454296
ENST00000582970ENST00000397466RNF213chr1778237577+TBCDchr1780828099+0.0165850560.98341495
ENST00000582970ENST00000539345RNF213chr1778237577+TBCDchr1780828099+0.0052618580.99473816
ENST00000319921ENST00000355528RNF213chr1778237577+TBCDchr1780828099+0.0054557850.99454415
ENST00000319921ENST00000397466RNF213chr1778237577+TBCDchr1780828099+0.0159776830.9840223
ENST00000319921ENST00000539345RNF213chr1778237577+TBCDchr1780828099+0.0052548750.99474514
ENST00000508628ENST00000355528RNF213chr1778237577+TBCDchr1780828100+0.0054045570.99459547
ENST00000508628ENST00000397466RNF213chr1778237577+TBCDchr1780828100+0.0165989290.9834011
ENST00000508628ENST00000539345RNF213chr1778237577+TBCDchr1780828100+0.0052083180.9947917
ENST00000456466ENST00000355528RNF213chr1778237577+TBCDchr1780828100+0.0054570070.99454296
ENST00000456466ENST00000397466RNF213chr1778237577+TBCDchr1780828100+0.0165850560.98341495
ENST00000456466ENST00000539345RNF213chr1778237577+TBCDchr1780828100+0.0052618580.99473816
ENST00000582970ENST00000355528RNF213chr1778237577+TBCDchr1780828100+0.0054570070.99454296
ENST00000582970ENST00000397466RNF213chr1778237577+TBCDchr1780828100+0.0165850560.98341495
ENST00000582970ENST00000539345RNF213chr1778237577+TBCDchr1780828100+0.0052618580.99473816
ENST00000319921ENST00000355528RNF213chr1778237577+TBCDchr1780828100+0.0054557850.99454415
ENST00000319921ENST00000397466RNF213chr1778237577+TBCDchr1780828100+0.0159776830.9840223
ENST00000319921ENST00000539345RNF213chr1778237577+TBCDchr1780828100+0.0052548750.99474514

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Fusion Genomic Features for RNF213-TBCD


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RNF213chr1778237577+TBCDchr1780828099+1.39E-060.99999857
RNF213chr1778237577+TBCDchr1780828099+1.39E-060.99999857
RNF213chr1778237577+TBCDchr1780828099+1.39E-060.99999857
RNF213chr1778237577+TBCDchr1780828099+1.39E-060.99999857

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for RNF213-TBCD


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:78237577/chr17:80828100)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTBCDchr17:78237577chr17:80828099ENST000003555281239557_5944391193.0RepeatNote=HEAT 2
TgeneTBCDchr17:78237577chr17:80828099ENST000003555281239596_6324391193.0RepeatNote=HEAT 3
TgeneTBCDchr17:78237577chr17:80828100ENST000003555281239557_5944391193.0RepeatNote=HEAT 2
TgeneTBCDchr17:78237577chr17:80828100ENST000003555281239596_6324391193.0RepeatNote=HEAT 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRNF213chr17:78237577chr17:80828099ENST00000319921+217343_374321064.0Coiled coilOntology_term=ECO:0000255
HgeneRNF213chr17:78237577chr17:80828099ENST00000508628+269343_374325257.0Coiled coilOntology_term=ECO:0000255
HgeneRNF213chr17:78237577chr17:80828099ENST00000582970+268343_374325208.0Coiled coilOntology_term=ECO:0000255
HgeneRNF213chr17:78237577chr17:80828100ENST00000319921+217343_374321064.0Coiled coilOntology_term=ECO:0000255
HgeneRNF213chr17:78237577chr17:80828100ENST00000508628+269343_374325257.0Coiled coilOntology_term=ECO:0000255
HgeneRNF213chr17:78237577chr17:80828100ENST00000582970+268343_374325208.0Coiled coilOntology_term=ECO:0000255
HgeneRNF213chr17:78237577chr17:80828099ENST00000319921+2173997_4036321064.0Zinc fingerRING-type
HgeneRNF213chr17:78237577chr17:80828099ENST00000508628+2693997_4036325257.0Zinc fingerRING-type
HgeneRNF213chr17:78237577chr17:80828099ENST00000582970+2683997_4036325208.0Zinc fingerRING-type
HgeneRNF213chr17:78237577chr17:80828100ENST00000319921+2173997_4036321064.0Zinc fingerRING-type
HgeneRNF213chr17:78237577chr17:80828100ENST00000508628+2693997_4036325257.0Zinc fingerRING-type
HgeneRNF213chr17:78237577chr17:80828100ENST00000582970+2683997_4036325208.0Zinc fingerRING-type
TgeneTBCDchr17:78237577chr17:80828099ENST000003555281239361_3994391193.0RepeatNote=HEAT 1
TgeneTBCDchr17:78237577chr17:80828100ENST000003555281239361_3994391193.0RepeatNote=HEAT 1


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Fusion Gene Sequence for RNF213-TBCD


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>74993_74993_1_RNF213-TBCD_RNF213_chr17_78237577_ENST00000319921_TBCD_chr17_80828099_ENST00000355528_length(transcript)=2884nt_BP=238nt
GCGCGCGGCAGGCGGCGAGCTCGGGGGCCGCAGAAAATGAAACTGAAGCCGTGGTCACGTGACAGGACATGTAGTATATAGCAGGCTGCC
AGCGACTCCTGCTCTTGCTTCTGGATCTGCAGGGCAGTCCCAGCAGGACCCATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGAGGAA
ACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCCATAGCAGTTGTCGCCGTGATCCTGAAGGCGCTGACCTAC
GACGAGAAGCGGGGTGCCTGCAGCGTGGGCACCAACGTCAGGGACGCCGCCTGCTACGTGTGCTGGGCCTTCGCGCGTGCCTATGAGCCT
CAGGAGCTGAAGCCCTTTGTGACTGCAATCTCGAGTGCACTGGTGATTGCTGCGGTGTTTGACCGAGACATAAACTGCAGAAGAGCAGCC
TCTGCCGCCTTCCAGGAGAATGTGGGGAGACAGGGCACTTTCCCTCATGGTATTGATATTTTGACCACAGCTGACTATTTTGCCGTCGGT
AACAGATCCAACTGTTTCCTGGTTATAAGTGTGTTTATTGCCGGCTTTCCTGAGTACACGCAGCCAATGATAGACCACCTGGTTACCATG
AAGATCAGCCACTGGGATGGGGTCATCCGAGAGTTGGCTGCGAGGGCGCTGCACAACCTGGCCCAGCAGGCACCCGAGTTCAGCGCCACG
CAAGTCTTCCCGAGGCTGCTGTCCATGACACTGAGTCCAGATCTTCACATGAGGCATGGGTCGATTCTCGCCTGCGCAGAAGTTGCTTAC
GCCTTGTACAAACTTGCAGCCCAAGAGAACAGGCCCGTCACGGACCATCTGGACGAGCAGGCAGTGCAGGGCCTGAAGCAGATTCACCAG
CAGCTCTATGATCGTCAGTTATACAGGGGTCTGGGAGGACAGCTCATGAGACAAGCAGTGTGTGTTTTAATAGAAAAGTTGTCACTTTCC
AAAATGCCCTTTAGAGGTGACACCGTAATTGATGGTTGGCAATGGCTGATAAATGACACTTTGAGACATCTCCATCTCATCTCAAGTCAC
TCCCGCCAGCAGATGAAGGATGCAGCAGTCTCGGCCCTGGCTGCTCTATGCAGTGAATATTACATGAAGGAGCCGGGGGAGGCAGATCCC
GCAATTCAGGAGGAGCTGATCACGCAGTACCTGGCTGAGCTTCGGAACCCCGAGGAGATGACTCGCTGTGGCTTCTCGTTGGCCTTGGGC
GCCCTTCCAGGCTTCCTTCTGAAAGGCCGGCTCCAGCAGGTTCTCACAGGTTTAAGAGCAGTTACCCACACTTCCCCCGAGGACGTAAGT
TTTGCTGAGTCCAGGAGAGACGGCTTGAAGGCCATTGCGAGGATTTGCCAGACTGTTGGTGTGAAAGCAGGAGCCCCAGACGAAGCTGTG
TGCGGAGAGAATGTTTCCCAGATTTACTGTGCGCTGCTGGGCTGCATGGACGACTACACCACGGACAGCAGAGGGGACGTGGGCACCTGG
GTCCGCAAGGCCGCCATGACCAGTCTGATGGATCTGACACTTCTGCTGGCTCGGAGCCAGCCTGAGCTGATCGAGGCCCATACCTGTGAG
CGCATCATGTGCTGTGTGGCCCAGCAGGCCAGTGAGAAGATTGACCGTTTCCGTGCTCACGCCGCCAGCGTGTTCCTGACGCTCCTGCAC
TTTGACAGCCCTCCCATCCCCCACGTGCCCCACCGAGGAGAACTGGAAAAGCTGTTTCCCAGGTCCGATGTGGCCTCCGTGAACTGGAGT
GCACCTTCCCAGGCCTTCCCACGCATCACCCAGCTCCTTGGGCTGCCCACCTACCGCTACCACGTCCTGCTGGGGCTAGTCGTGTCCCTG
GGCGGCTTGACGGAGTCGACGATCCGGCACTCCACCCAGAGCCTCTTTGAGTACATGAAGGGCATTCAGAGCGACCCGCAGGCCCTGGGC
AGCTTCAGCGGGACCCTTCTGCAGATCTTTGAGGACAACCTTCTGAATGAGAGGGTGTCCGTGCCGCTGCTGAAGACGCTGGACCACGTG
CTCACCCACGGCTGCTTCGACATCTTCACCACGGAGGAGGACCACCCCTTTGCTGTGAAGTTGCTTGCGCTCTGTAAGAAAGAAATCAAG
AATTCAAAAGATATCCAGAAGCTCCTGTCAGGCATCGCAGTGTTCTGCGAGATGGTGCAGTTCCCCGGCGACGTGAGGAGGCAGGCCCTC
CTGCAGCTGTGTCTGCTCCTCTGCCACCGTTTCCCGCTGATCCGGAAGACCACGGCCAGCCAGGTGTACGAGACATTGCTCACCTACAGT
GACGTCGTGGGCGCGGATGTGCTGGACGAGGTGGTGACTGTGCTCAGTGACACTGCGTGGGACGCGGAGCTTGCAGTGGTGAGAGAGCAG
CGCAACCGTCTGTGTGACCTTCTGGGCGTACCCAGGCCCCAGCTGGTGCCCCAGCCTGGTGCCTGCTGAAGCCAGTCCTGGAGCCCATAC
CTCACCCCTGCCTGGTGAGGATGTCTTGTTCCTGAGGGAGGCCGGTGTGGAAAGCCTCGCACAGTGGTGCCTCCAGCTGTTGAAGGGTAG
CGCTGGCCCTTGGAGGCTGGCACTAGCTGACAGCTTTTCCTCTCTGCACCTGCGCTCTGGTGACTTGGGGTGGACGCCTCTGCCTTCACT
TGAACACAAATGTGCTTCCTATAAAATCATGTACCAAGAAGTTCCTGCCTTTTGTCTCTGAGCCTGATGTGTGTAGGGGTGATGGAAAGG
CTCACTGCCCAGGGGTCAGCCAGAGGGGAGGTGGGCTGCACTCCTCCTGCCTGGAGACCAGGCCCCCTTCTTGCCTGGTGCTGTCCCTGC

>74993_74993_1_RNF213-TBCD_RNF213_chr17_78237577_ENST00000319921_TBCD_chr17_80828099_ENST00000355528_length(amino acids)=785AA_BP=25
MECPSCQHVSKEETPKFCSQCGERLPPAAPIAVVAVILKALTYDEKRGACSVGTNVRDAACYVCWAFARAYEPQELKPFVTAISSALVIA
AVFDRDINCRRAASAAFQENVGRQGTFPHGIDILTTADYFAVGNRSNCFLVISVFIAGFPEYTQPMIDHLVTMKISHWDGVIRELAARAL
HNLAQQAPEFSATQVFPRLLSMTLSPDLHMRHGSILACAEVAYALYKLAAQENRPVTDHLDEQAVQGLKQIHQQLYDRQLYRGLGGQLMR
QAVCVLIEKLSLSKMPFRGDTVIDGWQWLINDTLRHLHLISSHSRQQMKDAAVSALAALCSEYYMKEPGEADPAIQEELITQYLAELRNP
EEMTRCGFSLALGALPGFLLKGRLQQVLTGLRAVTHTSPEDVSFAESRRDGLKAIARICQTVGVKAGAPDEAVCGENVSQIYCALLGCMD
DYTTDSRGDVGTWVRKAAMTSLMDLTLLLARSQPELIEAHTCERIMCCVAQQASEKIDRFRAHAASVFLTLLHFDSPPIPHVPHRGELEK
LFPRSDVASVNWSAPSQAFPRITQLLGLPTYRYHVLLGLVVSLGGLTESTIRHSTQSLFEYMKGIQSDPQALGSFSGTLLQIFEDNLLNE
RVSVPLLKTLDHVLTHGCFDIFTTEEDHPFAVKLLALCKKEIKNSKDIQKLLSGIAVFCEMVQFPGDVRRQALLQLCLLLCHRFPLIRKT

--------------------------------------------------------------
>74993_74993_2_RNF213-TBCD_RNF213_chr17_78237577_ENST00000319921_TBCD_chr17_80828099_ENST00000397466_length(transcript)=1014nt_BP=238nt
GCGCGCGGCAGGCGGCGAGCTCGGGGGCCGCAGAAAATGAAACTGAAGCCGTGGTCACGTGACAGGACATGTAGTATATAGCAGGCTGCC
AGCGACTCCTGCTCTTGCTTCTGGATCTGCAGGGCAGTCCCAGCAGGACCCATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGAGGAA
ACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCCATAGCAGTTGTCGCCGTGATCCTGAAGGCGCTGACCTAC
GACGAGAAGCGGGGTGCCTGCAGCGTGGGCACCAACGTCAGGGACGCCGCCTGCTACGTGTGCTGGGCCTTCGCGCGTGCCTATGAGCCT
CAGGAGCTGAAGCCCTTTGTGACTGCAATCTCGAGTGCACTGGTGATTGCTGCGGTGTTTGACCGAGACATAAACTGCAGAAGAGCAGCC
TCTGCCGCCTTCCAGGAGAATGTGGGGAGACAGGGCACTTTCCCTCATGGTATTGATATTTTGACCACAGCTGACTATTTTGCCGTCGGT
AACAGATCCAACTGTTTCCTGGTTATAAGTGTGTTTATTGCCGGCTTTCCTGAGTACACGCAGCCAATGATAGACCACCTGGTTACCATG
AAGATCAGCCACTGGGATGGGGTCATCCGAGAGTTGGCTGCGAGGGCGCTGCACAACCTGGCCCAGCAGGCACCCGAGTTCAGCGCCACG
CAAGTCTTCCCGAGGCTGCTGTCCATGACACTGAGTCCAGATCTTCACATGAGGCATGGGTCGATTCTCGCCTGCGCAGAAGTTGCTTAC
GCCTTGTACAAACTTGCAGCCCAAGAGAACAGGCCCGTCACGGACCATCTGGACGAGCAGGCAGTGCAGGGCCTGAAGCAGATTCACCAG
CAGCCGTGCATCTGCAGCTGGGGTCTGATGTCTCCTGAAAGTAAAGCAGAATTTTGTGTGTGCGTCTGTCGGATTTCTCTGGGGAGACAG

>74993_74993_2_RNF213-TBCD_RNF213_chr17_78237577_ENST00000319921_TBCD_chr17_80828099_ENST00000397466_length(amino acids)=314AA_BP=0
MNTLSPQRNPTDAHTKFCFTFRRHQTPAADARLLVNLLQALHCLLVQMVRDGPVLLGCKFVQGVSNFCAGENRPMPHVKIWTQCHGQQPR
EDLRGAELGCLLGQVVQRPRSQLSDDPIPVADLHGNQVVYHWLRVLRKAGNKHTYNQETVGSVTDGKIVSCGQNINTMRESALSPHILLE
GGRGCSSAVYVSVKHRSNHQCTRDCSHKGLQLLRLIGTREGPAHVAGGVPDVGAHAAGTPLLVVGQRLQDHGDNCYGGCRRQPLSALAAE

--------------------------------------------------------------
>74993_74993_3_RNF213-TBCD_RNF213_chr17_78237577_ENST00000319921_TBCD_chr17_80828099_ENST00000539345_length(transcript)=2859nt_BP=238nt
GCGCGCGGCAGGCGGCGAGCTCGGGGGCCGCAGAAAATGAAACTGAAGCCGTGGTCACGTGACAGGACATGTAGTATATAGCAGGCTGCC
AGCGACTCCTGCTCTTGCTTCTGGATCTGCAGGGCAGTCCCAGCAGGACCCATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGAGGAA
ACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCCATAGCAGTTGTCGCCGTGATCCTGAAGGCGCTGACCTAC
GACGAGAAGCGGGGTGCCTGCAGCGTGGGCACCAACGTCAGGGACGCCGCCTGCTACGTGTGCTGGGCCTTCGCGCGTGCCTATGAGCCT
CAGGAGCTGAAGCCCTTTGTGACTGCAATCTCGAGTGCACTGGTGATTGCTGCGGTGTTTGACCGAGACATAAACTGCAGAAGAGCAGCC
TCTGCCGCCTTCCAGGAGAATGTGGGGAGACAGGGCACTTTCCCTCATGGTATTGATATTTTGACCACAGCTGACTATTTTGCCGTCGGT
AACAGATCCAACTGTTTCCTGGTTATAAGTGTGTTTATTGCCGGCTTTCCTGAGTACACGCAGCCAATGATAGACCACCTGGTTACCATG
AAGATCAGCCACTGGGATGGGGTCATCCGAGAGTTGGCTGCGAGGGCGCTGCACAACCTGGCCCAGCAGGCACCCGAGTTCAGCGCCACG
CAAGTCTTCCCGAGGCTGCTGTCCATGACACTGAGTCCAGATCTTCACATGAGGCATGGGTCGATTCTCGCCTGCGCAGAAGTTGCTTAC
GCCTTGTACAAACTTGCAGCCCAAGAGAACAGGCCCGTCACGGACCATCTGGACGAGCAGGCAGTGCAGGGCCTGAAGCAGATTCACCAG
CAGCTCTATGATCGTCAGTTATACAGGGGTCTGGGAGGACAGCTCATGAGACAAGCAGTGTGTGTTTTAATAGAAAAGTTGTCACTTTCC
AAAATGCCCTTTAGAGGTGACACCGTAATTGATGGTTGGCAATGGCTGATAAATGACACTTTGAGACATCTCCATCTCATCTCAAGTCAC
TCCCGCCAGCAGATGAAGGATGCAGCAGTCTCGGCCCTGGCTGCTCTATGCAGTGAATATTACATGAAGGAGCCGGGGGAGGCAGATCCC
GCAATTCAGGAGGAGCTGATCACGCAGTACCTGGCTGAGCTTCGGAACCCCGAGGAGATGACTCGCTGTGGCTTCTCGTTGGCCTTGGGC
GCCCTTCCAGGCTTCCTTCTGAAAGGCCGGCTCCAGCAGGTTCTCACAGGTTTAAGAGCAGTTACCCACACTTCCCCCGAGGACGTAAGT
TTTGCTGAGTCCAGGAGAGACGGCTTGAAGGCCATTGCGAGGATTTGCCAGACTGTTGGTGTGAAAGCAGGAGCCCCAGACGAAGCTGTG
TGCGGAGAGAATGTTTCCCAGATTTACTGTGCGCTGCTGGGCTGCATGGACGACTACACCACGGACAGCAGAGGGGACGTGGGCACCTGG
GTCCGCAAGGCCGCCATGACCAGTCTGATGGATCTGACACTTCTGCTGGCTCGGAGCCAGCCTGAGCTGATCGAGGCCCATACCTGTGAG
CGCATCATGTGCTGTGTGGCCCAGCAGGCCAGTGAGAAGATTGACCGTTTCCGTGCTCACGCCGCCAGCGTGTTCCTGACGCTCCTGCAC
TTTGACAGCCCTCCCATCCCCCACGTGCCCCACCGAGGAGAACTGGAAAAGCTGTTTCCCAGGTCCGATGTGGCCTCCGTGAACTGGAGT
GCACCTTCCCAGGCCTTCCCACGCATCACCCAGCTCCTTGGGCTGCCCACCTACCGCTACCACGTCCTGCTGGGGCTAGTCGTGTCCCTG
GGCGGCTTGACGGAGTCGACGATCCGGCACTCCACCCAGAGCCTCTTTGAGTACATGAAGGGCATTCAGAGCGACCCGCAGGCCCTGGGC
AGCTTCAGCGGGACCCTTCTGCAGATCTTTGAGGACAACCTTCTGAATGAGAGGGTGTCCGTGCCGCTGCTGAAGACGCTGGACCACGTG
CTCACCCACGGCTGCTTCGACATCTTCACCACGGAGGAGGACCACCCCTTTGCTGTGAAGTTGCTTGCGCTCTGTAAGAAAGAAATCAAG
AATTCAAAAGATATCCAGAAGCTCCTGTCAGGCATCGCAGTTGACTTTCCAAGTGCGACACTCGTGTGTGTAGGCACAGTGCAGATGTAC
GCACACACACACCTCCGGCTTGGGGCCCCAGGCCCGCACTGTGCTCACGGATCTGCTCTGCCCAGGTTCTGCGAGATGGTGCAGTTCCCC
GGCGACGTGAGGAGGCAGGCCCTCCTGCAGCTGTGTCTGCTCCTCTGCCACCGTTTCCCGCTGATCCGGAAGACCACGGCCAGCCAGGTG
TACGAGACATTGCTCACCTACAGTGACGTCGTGGGCGCGGATGTGCTGGACGAGGTGGTGACTGTGCTCAGTGACACTGCGTGGGACGCG
GAGCTTGCAGTGGTGAGAGAGCAGCGCAACCGTCTGTGTGACCTTCTGGGCGTACCCAGGCCCCAGCTGGTGCCCCAGCCTGGTGCCTGC
TGAAGCCAGTCCTGGAGCCCATACCTCACCCCTGCCTGGTGAGGATGTCTTGTTCCTGAGGGAGGCCGGTGTGGAAAGCCTCGCACAGTG
GTGCCTCCAGCTGTTGAAGGGTAGCGCTGGCCCTTGGAGGCTGGCACTAGCTGACAGCTTTTCCTCTCTGCACCTGCGCTCTGGTGACTT

>74993_74993_3_RNF213-TBCD_RNF213_chr17_78237577_ENST00000319921_TBCD_chr17_80828099_ENST00000539345_length(amino acids)=823AA_BP=25
MECPSCQHVSKEETPKFCSQCGERLPPAAPIAVVAVILKALTYDEKRGACSVGTNVRDAACYVCWAFARAYEPQELKPFVTAISSALVIA
AVFDRDINCRRAASAAFQENVGRQGTFPHGIDILTTADYFAVGNRSNCFLVISVFIAGFPEYTQPMIDHLVTMKISHWDGVIRELAARAL
HNLAQQAPEFSATQVFPRLLSMTLSPDLHMRHGSILACAEVAYALYKLAAQENRPVTDHLDEQAVQGLKQIHQQLYDRQLYRGLGGQLMR
QAVCVLIEKLSLSKMPFRGDTVIDGWQWLINDTLRHLHLISSHSRQQMKDAAVSALAALCSEYYMKEPGEADPAIQEELITQYLAELRNP
EEMTRCGFSLALGALPGFLLKGRLQQVLTGLRAVTHTSPEDVSFAESRRDGLKAIARICQTVGVKAGAPDEAVCGENVSQIYCALLGCMD
DYTTDSRGDVGTWVRKAAMTSLMDLTLLLARSQPELIEAHTCERIMCCVAQQASEKIDRFRAHAASVFLTLLHFDSPPIPHVPHRGELEK
LFPRSDVASVNWSAPSQAFPRITQLLGLPTYRYHVLLGLVVSLGGLTESTIRHSTQSLFEYMKGIQSDPQALGSFSGTLLQIFEDNLLNE
RVSVPLLKTLDHVLTHGCFDIFTTEEDHPFAVKLLALCKKEIKNSKDIQKLLSGIAVDFPSATLVCVGTVQMYAHTHLRLGAPGPHCAHG
SALPRFCEMVQFPGDVRRQALLQLCLLLCHRFPLIRKTTASQVYETLLTYSDVVGADVLDEVVTVLSDTAWDAELAVVREQRNRLCDLLG

--------------------------------------------------------------
>74993_74993_4_RNF213-TBCD_RNF213_chr17_78237577_ENST00000319921_TBCD_chr17_80828100_ENST00000355528_length(transcript)=2884nt_BP=238nt
GCGCGCGGCAGGCGGCGAGCTCGGGGGCCGCAGAAAATGAAACTGAAGCCGTGGTCACGTGACAGGACATGTAGTATATAGCAGGCTGCC
AGCGACTCCTGCTCTTGCTTCTGGATCTGCAGGGCAGTCCCAGCAGGACCCATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGAGGAA
ACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCCATAGCAGTTGTCGCCGTGATCCTGAAGGCGCTGACCTAC
GACGAGAAGCGGGGTGCCTGCAGCGTGGGCACCAACGTCAGGGACGCCGCCTGCTACGTGTGCTGGGCCTTCGCGCGTGCCTATGAGCCT
CAGGAGCTGAAGCCCTTTGTGACTGCAATCTCGAGTGCACTGGTGATTGCTGCGGTGTTTGACCGAGACATAAACTGCAGAAGAGCAGCC
TCTGCCGCCTTCCAGGAGAATGTGGGGAGACAGGGCACTTTCCCTCATGGTATTGATATTTTGACCACAGCTGACTATTTTGCCGTCGGT
AACAGATCCAACTGTTTCCTGGTTATAAGTGTGTTTATTGCCGGCTTTCCTGAGTACACGCAGCCAATGATAGACCACCTGGTTACCATG
AAGATCAGCCACTGGGATGGGGTCATCCGAGAGTTGGCTGCGAGGGCGCTGCACAACCTGGCCCAGCAGGCACCCGAGTTCAGCGCCACG
CAAGTCTTCCCGAGGCTGCTGTCCATGACACTGAGTCCAGATCTTCACATGAGGCATGGGTCGATTCTCGCCTGCGCAGAAGTTGCTTAC
GCCTTGTACAAACTTGCAGCCCAAGAGAACAGGCCCGTCACGGACCATCTGGACGAGCAGGCAGTGCAGGGCCTGAAGCAGATTCACCAG
CAGCTCTATGATCGTCAGTTATACAGGGGTCTGGGAGGACAGCTCATGAGACAAGCAGTGTGTGTTTTAATAGAAAAGTTGTCACTTTCC
AAAATGCCCTTTAGAGGTGACACCGTAATTGATGGTTGGCAATGGCTGATAAATGACACTTTGAGACATCTCCATCTCATCTCAAGTCAC
TCCCGCCAGCAGATGAAGGATGCAGCAGTCTCGGCCCTGGCTGCTCTATGCAGTGAATATTACATGAAGGAGCCGGGGGAGGCAGATCCC
GCAATTCAGGAGGAGCTGATCACGCAGTACCTGGCTGAGCTTCGGAACCCCGAGGAGATGACTCGCTGTGGCTTCTCGTTGGCCTTGGGC
GCCCTTCCAGGCTTCCTTCTGAAAGGCCGGCTCCAGCAGGTTCTCACAGGTTTAAGAGCAGTTACCCACACTTCCCCCGAGGACGTAAGT
TTTGCTGAGTCCAGGAGAGACGGCTTGAAGGCCATTGCGAGGATTTGCCAGACTGTTGGTGTGAAAGCAGGAGCCCCAGACGAAGCTGTG
TGCGGAGAGAATGTTTCCCAGATTTACTGTGCGCTGCTGGGCTGCATGGACGACTACACCACGGACAGCAGAGGGGACGTGGGCACCTGG
GTCCGCAAGGCCGCCATGACCAGTCTGATGGATCTGACACTTCTGCTGGCTCGGAGCCAGCCTGAGCTGATCGAGGCCCATACCTGTGAG
CGCATCATGTGCTGTGTGGCCCAGCAGGCCAGTGAGAAGATTGACCGTTTCCGTGCTCACGCCGCCAGCGTGTTCCTGACGCTCCTGCAC
TTTGACAGCCCTCCCATCCCCCACGTGCCCCACCGAGGAGAACTGGAAAAGCTGTTTCCCAGGTCCGATGTGGCCTCCGTGAACTGGAGT
GCACCTTCCCAGGCCTTCCCACGCATCACCCAGCTCCTTGGGCTGCCCACCTACCGCTACCACGTCCTGCTGGGGCTAGTCGTGTCCCTG
GGCGGCTTGACGGAGTCGACGATCCGGCACTCCACCCAGAGCCTCTTTGAGTACATGAAGGGCATTCAGAGCGACCCGCAGGCCCTGGGC
AGCTTCAGCGGGACCCTTCTGCAGATCTTTGAGGACAACCTTCTGAATGAGAGGGTGTCCGTGCCGCTGCTGAAGACGCTGGACCACGTG
CTCACCCACGGCTGCTTCGACATCTTCACCACGGAGGAGGACCACCCCTTTGCTGTGAAGTTGCTTGCGCTCTGTAAGAAAGAAATCAAG
AATTCAAAAGATATCCAGAAGCTCCTGTCAGGCATCGCAGTGTTCTGCGAGATGGTGCAGTTCCCCGGCGACGTGAGGAGGCAGGCCCTC
CTGCAGCTGTGTCTGCTCCTCTGCCACCGTTTCCCGCTGATCCGGAAGACCACGGCCAGCCAGGTGTACGAGACATTGCTCACCTACAGT
GACGTCGTGGGCGCGGATGTGCTGGACGAGGTGGTGACTGTGCTCAGTGACACTGCGTGGGACGCGGAGCTTGCAGTGGTGAGAGAGCAG
CGCAACCGTCTGTGTGACCTTCTGGGCGTACCCAGGCCCCAGCTGGTGCCCCAGCCTGGTGCCTGCTGAAGCCAGTCCTGGAGCCCATAC
CTCACCCCTGCCTGGTGAGGATGTCTTGTTCCTGAGGGAGGCCGGTGTGGAAAGCCTCGCACAGTGGTGCCTCCAGCTGTTGAAGGGTAG
CGCTGGCCCTTGGAGGCTGGCACTAGCTGACAGCTTTTCCTCTCTGCACCTGCGCTCTGGTGACTTGGGGTGGACGCCTCTGCCTTCACT
TGAACACAAATGTGCTTCCTATAAAATCATGTACCAAGAAGTTCCTGCCTTTTGTCTCTGAGCCTGATGTGTGTAGGGGTGATGGAAAGG
CTCACTGCCCAGGGGTCAGCCAGAGGGGAGGTGGGCTGCACTCCTCCTGCCTGGAGACCAGGCCCCCTTCTTGCCTGGTGCTGTCCCTGC

>74993_74993_4_RNF213-TBCD_RNF213_chr17_78237577_ENST00000319921_TBCD_chr17_80828100_ENST00000355528_length(amino acids)=785AA_BP=25
MECPSCQHVSKEETPKFCSQCGERLPPAAPIAVVAVILKALTYDEKRGACSVGTNVRDAACYVCWAFARAYEPQELKPFVTAISSALVIA
AVFDRDINCRRAASAAFQENVGRQGTFPHGIDILTTADYFAVGNRSNCFLVISVFIAGFPEYTQPMIDHLVTMKISHWDGVIRELAARAL
HNLAQQAPEFSATQVFPRLLSMTLSPDLHMRHGSILACAEVAYALYKLAAQENRPVTDHLDEQAVQGLKQIHQQLYDRQLYRGLGGQLMR
QAVCVLIEKLSLSKMPFRGDTVIDGWQWLINDTLRHLHLISSHSRQQMKDAAVSALAALCSEYYMKEPGEADPAIQEELITQYLAELRNP
EEMTRCGFSLALGALPGFLLKGRLQQVLTGLRAVTHTSPEDVSFAESRRDGLKAIARICQTVGVKAGAPDEAVCGENVSQIYCALLGCMD
DYTTDSRGDVGTWVRKAAMTSLMDLTLLLARSQPELIEAHTCERIMCCVAQQASEKIDRFRAHAASVFLTLLHFDSPPIPHVPHRGELEK
LFPRSDVASVNWSAPSQAFPRITQLLGLPTYRYHVLLGLVVSLGGLTESTIRHSTQSLFEYMKGIQSDPQALGSFSGTLLQIFEDNLLNE
RVSVPLLKTLDHVLTHGCFDIFTTEEDHPFAVKLLALCKKEIKNSKDIQKLLSGIAVFCEMVQFPGDVRRQALLQLCLLLCHRFPLIRKT

--------------------------------------------------------------
>74993_74993_5_RNF213-TBCD_RNF213_chr17_78237577_ENST00000319921_TBCD_chr17_80828100_ENST00000397466_length(transcript)=1014nt_BP=238nt
GCGCGCGGCAGGCGGCGAGCTCGGGGGCCGCAGAAAATGAAACTGAAGCCGTGGTCACGTGACAGGACATGTAGTATATAGCAGGCTGCC
AGCGACTCCTGCTCTTGCTTCTGGATCTGCAGGGCAGTCCCAGCAGGACCCATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGAGGAA
ACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCCATAGCAGTTGTCGCCGTGATCCTGAAGGCGCTGACCTAC
GACGAGAAGCGGGGTGCCTGCAGCGTGGGCACCAACGTCAGGGACGCCGCCTGCTACGTGTGCTGGGCCTTCGCGCGTGCCTATGAGCCT
CAGGAGCTGAAGCCCTTTGTGACTGCAATCTCGAGTGCACTGGTGATTGCTGCGGTGTTTGACCGAGACATAAACTGCAGAAGAGCAGCC
TCTGCCGCCTTCCAGGAGAATGTGGGGAGACAGGGCACTTTCCCTCATGGTATTGATATTTTGACCACAGCTGACTATTTTGCCGTCGGT
AACAGATCCAACTGTTTCCTGGTTATAAGTGTGTTTATTGCCGGCTTTCCTGAGTACACGCAGCCAATGATAGACCACCTGGTTACCATG
AAGATCAGCCACTGGGATGGGGTCATCCGAGAGTTGGCTGCGAGGGCGCTGCACAACCTGGCCCAGCAGGCACCCGAGTTCAGCGCCACG
CAAGTCTTCCCGAGGCTGCTGTCCATGACACTGAGTCCAGATCTTCACATGAGGCATGGGTCGATTCTCGCCTGCGCAGAAGTTGCTTAC
GCCTTGTACAAACTTGCAGCCCAAGAGAACAGGCCCGTCACGGACCATCTGGACGAGCAGGCAGTGCAGGGCCTGAAGCAGATTCACCAG
CAGCCGTGCATCTGCAGCTGGGGTCTGATGTCTCCTGAAAGTAAAGCAGAATTTTGTGTGTGCGTCTGTCGGATTTCTCTGGGGAGACAG

>74993_74993_5_RNF213-TBCD_RNF213_chr17_78237577_ENST00000319921_TBCD_chr17_80828100_ENST00000397466_length(amino acids)=314AA_BP=0
MNTLSPQRNPTDAHTKFCFTFRRHQTPAADARLLVNLLQALHCLLVQMVRDGPVLLGCKFVQGVSNFCAGENRPMPHVKIWTQCHGQQPR
EDLRGAELGCLLGQVVQRPRSQLSDDPIPVADLHGNQVVYHWLRVLRKAGNKHTYNQETVGSVTDGKIVSCGQNINTMRESALSPHILLE
GGRGCSSAVYVSVKHRSNHQCTRDCSHKGLQLLRLIGTREGPAHVAGGVPDVGAHAAGTPLLVVGQRLQDHGDNCYGGCRRQPLSALAAE

--------------------------------------------------------------
>74993_74993_6_RNF213-TBCD_RNF213_chr17_78237577_ENST00000319921_TBCD_chr17_80828100_ENST00000539345_length(transcript)=2859nt_BP=238nt
GCGCGCGGCAGGCGGCGAGCTCGGGGGCCGCAGAAAATGAAACTGAAGCCGTGGTCACGTGACAGGACATGTAGTATATAGCAGGCTGCC
AGCGACTCCTGCTCTTGCTTCTGGATCTGCAGGGCAGTCCCAGCAGGACCCATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGAGGAA
ACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCCATAGCAGTTGTCGCCGTGATCCTGAAGGCGCTGACCTAC
GACGAGAAGCGGGGTGCCTGCAGCGTGGGCACCAACGTCAGGGACGCCGCCTGCTACGTGTGCTGGGCCTTCGCGCGTGCCTATGAGCCT
CAGGAGCTGAAGCCCTTTGTGACTGCAATCTCGAGTGCACTGGTGATTGCTGCGGTGTTTGACCGAGACATAAACTGCAGAAGAGCAGCC
TCTGCCGCCTTCCAGGAGAATGTGGGGAGACAGGGCACTTTCCCTCATGGTATTGATATTTTGACCACAGCTGACTATTTTGCCGTCGGT
AACAGATCCAACTGTTTCCTGGTTATAAGTGTGTTTATTGCCGGCTTTCCTGAGTACACGCAGCCAATGATAGACCACCTGGTTACCATG
AAGATCAGCCACTGGGATGGGGTCATCCGAGAGTTGGCTGCGAGGGCGCTGCACAACCTGGCCCAGCAGGCACCCGAGTTCAGCGCCACG
CAAGTCTTCCCGAGGCTGCTGTCCATGACACTGAGTCCAGATCTTCACATGAGGCATGGGTCGATTCTCGCCTGCGCAGAAGTTGCTTAC
GCCTTGTACAAACTTGCAGCCCAAGAGAACAGGCCCGTCACGGACCATCTGGACGAGCAGGCAGTGCAGGGCCTGAAGCAGATTCACCAG
CAGCTCTATGATCGTCAGTTATACAGGGGTCTGGGAGGACAGCTCATGAGACAAGCAGTGTGTGTTTTAATAGAAAAGTTGTCACTTTCC
AAAATGCCCTTTAGAGGTGACACCGTAATTGATGGTTGGCAATGGCTGATAAATGACACTTTGAGACATCTCCATCTCATCTCAAGTCAC
TCCCGCCAGCAGATGAAGGATGCAGCAGTCTCGGCCCTGGCTGCTCTATGCAGTGAATATTACATGAAGGAGCCGGGGGAGGCAGATCCC
GCAATTCAGGAGGAGCTGATCACGCAGTACCTGGCTGAGCTTCGGAACCCCGAGGAGATGACTCGCTGTGGCTTCTCGTTGGCCTTGGGC
GCCCTTCCAGGCTTCCTTCTGAAAGGCCGGCTCCAGCAGGTTCTCACAGGTTTAAGAGCAGTTACCCACACTTCCCCCGAGGACGTAAGT
TTTGCTGAGTCCAGGAGAGACGGCTTGAAGGCCATTGCGAGGATTTGCCAGACTGTTGGTGTGAAAGCAGGAGCCCCAGACGAAGCTGTG
TGCGGAGAGAATGTTTCCCAGATTTACTGTGCGCTGCTGGGCTGCATGGACGACTACACCACGGACAGCAGAGGGGACGTGGGCACCTGG
GTCCGCAAGGCCGCCATGACCAGTCTGATGGATCTGACACTTCTGCTGGCTCGGAGCCAGCCTGAGCTGATCGAGGCCCATACCTGTGAG
CGCATCATGTGCTGTGTGGCCCAGCAGGCCAGTGAGAAGATTGACCGTTTCCGTGCTCACGCCGCCAGCGTGTTCCTGACGCTCCTGCAC
TTTGACAGCCCTCCCATCCCCCACGTGCCCCACCGAGGAGAACTGGAAAAGCTGTTTCCCAGGTCCGATGTGGCCTCCGTGAACTGGAGT
GCACCTTCCCAGGCCTTCCCACGCATCACCCAGCTCCTTGGGCTGCCCACCTACCGCTACCACGTCCTGCTGGGGCTAGTCGTGTCCCTG
GGCGGCTTGACGGAGTCGACGATCCGGCACTCCACCCAGAGCCTCTTTGAGTACATGAAGGGCATTCAGAGCGACCCGCAGGCCCTGGGC
AGCTTCAGCGGGACCCTTCTGCAGATCTTTGAGGACAACCTTCTGAATGAGAGGGTGTCCGTGCCGCTGCTGAAGACGCTGGACCACGTG
CTCACCCACGGCTGCTTCGACATCTTCACCACGGAGGAGGACCACCCCTTTGCTGTGAAGTTGCTTGCGCTCTGTAAGAAAGAAATCAAG
AATTCAAAAGATATCCAGAAGCTCCTGTCAGGCATCGCAGTTGACTTTCCAAGTGCGACACTCGTGTGTGTAGGCACAGTGCAGATGTAC
GCACACACACACCTCCGGCTTGGGGCCCCAGGCCCGCACTGTGCTCACGGATCTGCTCTGCCCAGGTTCTGCGAGATGGTGCAGTTCCCC
GGCGACGTGAGGAGGCAGGCCCTCCTGCAGCTGTGTCTGCTCCTCTGCCACCGTTTCCCGCTGATCCGGAAGACCACGGCCAGCCAGGTG
TACGAGACATTGCTCACCTACAGTGACGTCGTGGGCGCGGATGTGCTGGACGAGGTGGTGACTGTGCTCAGTGACACTGCGTGGGACGCG
GAGCTTGCAGTGGTGAGAGAGCAGCGCAACCGTCTGTGTGACCTTCTGGGCGTACCCAGGCCCCAGCTGGTGCCCCAGCCTGGTGCCTGC
TGAAGCCAGTCCTGGAGCCCATACCTCACCCCTGCCTGGTGAGGATGTCTTGTTCCTGAGGGAGGCCGGTGTGGAAAGCCTCGCACAGTG
GTGCCTCCAGCTGTTGAAGGGTAGCGCTGGCCCTTGGAGGCTGGCACTAGCTGACAGCTTTTCCTCTCTGCACCTGCGCTCTGGTGACTT

>74993_74993_6_RNF213-TBCD_RNF213_chr17_78237577_ENST00000319921_TBCD_chr17_80828100_ENST00000539345_length(amino acids)=823AA_BP=25
MECPSCQHVSKEETPKFCSQCGERLPPAAPIAVVAVILKALTYDEKRGACSVGTNVRDAACYVCWAFARAYEPQELKPFVTAISSALVIA
AVFDRDINCRRAASAAFQENVGRQGTFPHGIDILTTADYFAVGNRSNCFLVISVFIAGFPEYTQPMIDHLVTMKISHWDGVIRELAARAL
HNLAQQAPEFSATQVFPRLLSMTLSPDLHMRHGSILACAEVAYALYKLAAQENRPVTDHLDEQAVQGLKQIHQQLYDRQLYRGLGGQLMR
QAVCVLIEKLSLSKMPFRGDTVIDGWQWLINDTLRHLHLISSHSRQQMKDAAVSALAALCSEYYMKEPGEADPAIQEELITQYLAELRNP
EEMTRCGFSLALGALPGFLLKGRLQQVLTGLRAVTHTSPEDVSFAESRRDGLKAIARICQTVGVKAGAPDEAVCGENVSQIYCALLGCMD
DYTTDSRGDVGTWVRKAAMTSLMDLTLLLARSQPELIEAHTCERIMCCVAQQASEKIDRFRAHAASVFLTLLHFDSPPIPHVPHRGELEK
LFPRSDVASVNWSAPSQAFPRITQLLGLPTYRYHVLLGLVVSLGGLTESTIRHSTQSLFEYMKGIQSDPQALGSFSGTLLQIFEDNLLNE
RVSVPLLKTLDHVLTHGCFDIFTTEEDHPFAVKLLALCKKEIKNSKDIQKLLSGIAVDFPSATLVCVGTVQMYAHTHLRLGAPGPHCAHG
SALPRFCEMVQFPGDVRRQALLQLCLLLCHRFPLIRKTTASQVYETLLTYSDVVGADVLDEVVTVLSDTAWDAELAVVREQRNRLCDLLG

--------------------------------------------------------------
>74993_74993_7_RNF213-TBCD_RNF213_chr17_78237577_ENST00000456466_TBCD_chr17_80828099_ENST00000355528_length(transcript)=2886nt_BP=240nt
CAGCGCGCGGCAGGCGGCGAGCTCGGGGGCCGCAGAAAATGAAACTGAAGCCGTGGTCACGTGACAGGACATGTAGTATATAGCAGGCTG
CCAGCGACTCCTGCTCTTGCTTCTGGATCTGCAGGGCAGTCCCAGCAGGACCCATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGAGG
AAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCCATAGCAGTTGTCGCCGTGATCCTGAAGGCGCTGACCT
ACGACGAGAAGCGGGGTGCCTGCAGCGTGGGCACCAACGTCAGGGACGCCGCCTGCTACGTGTGCTGGGCCTTCGCGCGTGCCTATGAGC
CTCAGGAGCTGAAGCCCTTTGTGACTGCAATCTCGAGTGCACTGGTGATTGCTGCGGTGTTTGACCGAGACATAAACTGCAGAAGAGCAG
CCTCTGCCGCCTTCCAGGAGAATGTGGGGAGACAGGGCACTTTCCCTCATGGTATTGATATTTTGACCACAGCTGACTATTTTGCCGTCG
GTAACAGATCCAACTGTTTCCTGGTTATAAGTGTGTTTATTGCCGGCTTTCCTGAGTACACGCAGCCAATGATAGACCACCTGGTTACCA
TGAAGATCAGCCACTGGGATGGGGTCATCCGAGAGTTGGCTGCGAGGGCGCTGCACAACCTGGCCCAGCAGGCACCCGAGTTCAGCGCCA
CGCAAGTCTTCCCGAGGCTGCTGTCCATGACACTGAGTCCAGATCTTCACATGAGGCATGGGTCGATTCTCGCCTGCGCAGAAGTTGCTT
ACGCCTTGTACAAACTTGCAGCCCAAGAGAACAGGCCCGTCACGGACCATCTGGACGAGCAGGCAGTGCAGGGCCTGAAGCAGATTCACC
AGCAGCTCTATGATCGTCAGTTATACAGGGGTCTGGGAGGACAGCTCATGAGACAAGCAGTGTGTGTTTTAATAGAAAAGTTGTCACTTT
CCAAAATGCCCTTTAGAGGTGACACCGTAATTGATGGTTGGCAATGGCTGATAAATGACACTTTGAGACATCTCCATCTCATCTCAAGTC
ACTCCCGCCAGCAGATGAAGGATGCAGCAGTCTCGGCCCTGGCTGCTCTATGCAGTGAATATTACATGAAGGAGCCGGGGGAGGCAGATC
CCGCAATTCAGGAGGAGCTGATCACGCAGTACCTGGCTGAGCTTCGGAACCCCGAGGAGATGACTCGCTGTGGCTTCTCGTTGGCCTTGG
GCGCCCTTCCAGGCTTCCTTCTGAAAGGCCGGCTCCAGCAGGTTCTCACAGGTTTAAGAGCAGTTACCCACACTTCCCCCGAGGACGTAA
GTTTTGCTGAGTCCAGGAGAGACGGCTTGAAGGCCATTGCGAGGATTTGCCAGACTGTTGGTGTGAAAGCAGGAGCCCCAGACGAAGCTG
TGTGCGGAGAGAATGTTTCCCAGATTTACTGTGCGCTGCTGGGCTGCATGGACGACTACACCACGGACAGCAGAGGGGACGTGGGCACCT
GGGTCCGCAAGGCCGCCATGACCAGTCTGATGGATCTGACACTTCTGCTGGCTCGGAGCCAGCCTGAGCTGATCGAGGCCCATACCTGTG
AGCGCATCATGTGCTGTGTGGCCCAGCAGGCCAGTGAGAAGATTGACCGTTTCCGTGCTCACGCCGCCAGCGTGTTCCTGACGCTCCTGC
ACTTTGACAGCCCTCCCATCCCCCACGTGCCCCACCGAGGAGAACTGGAAAAGCTGTTTCCCAGGTCCGATGTGGCCTCCGTGAACTGGA
GTGCACCTTCCCAGGCCTTCCCACGCATCACCCAGCTCCTTGGGCTGCCCACCTACCGCTACCACGTCCTGCTGGGGCTAGTCGTGTCCC
TGGGCGGCTTGACGGAGTCGACGATCCGGCACTCCACCCAGAGCCTCTTTGAGTACATGAAGGGCATTCAGAGCGACCCGCAGGCCCTGG
GCAGCTTCAGCGGGACCCTTCTGCAGATCTTTGAGGACAACCTTCTGAATGAGAGGGTGTCCGTGCCGCTGCTGAAGACGCTGGACCACG
TGCTCACCCACGGCTGCTTCGACATCTTCACCACGGAGGAGGACCACCCCTTTGCTGTGAAGTTGCTTGCGCTCTGTAAGAAAGAAATCA
AGAATTCAAAAGATATCCAGAAGCTCCTGTCAGGCATCGCAGTGTTCTGCGAGATGGTGCAGTTCCCCGGCGACGTGAGGAGGCAGGCCC
TCCTGCAGCTGTGTCTGCTCCTCTGCCACCGTTTCCCGCTGATCCGGAAGACCACGGCCAGCCAGGTGTACGAGACATTGCTCACCTACA
GTGACGTCGTGGGCGCGGATGTGCTGGACGAGGTGGTGACTGTGCTCAGTGACACTGCGTGGGACGCGGAGCTTGCAGTGGTGAGAGAGC
AGCGCAACCGTCTGTGTGACCTTCTGGGCGTACCCAGGCCCCAGCTGGTGCCCCAGCCTGGTGCCTGCTGAAGCCAGTCCTGGAGCCCAT
ACCTCACCCCTGCCTGGTGAGGATGTCTTGTTCCTGAGGGAGGCCGGTGTGGAAAGCCTCGCACAGTGGTGCCTCCAGCTGTTGAAGGGT
AGCGCTGGCCCTTGGAGGCTGGCACTAGCTGACAGCTTTTCCTCTCTGCACCTGCGCTCTGGTGACTTGGGGTGGACGCCTCTGCCTTCA
CTTGAACACAAATGTGCTTCCTATAAAATCATGTACCAAGAAGTTCCTGCCTTTTGTCTCTGAGCCTGATGTGTGTAGGGGTGATGGAAA
GGCTCACTGCCCAGGGGTCAGCCAGAGGGGAGGTGGGCTGCACTCCTCCTGCCTGGAGACCAGGCCCCCTTCTTGCCTGGTGCTGTCCCT

>74993_74993_7_RNF213-TBCD_RNF213_chr17_78237577_ENST00000456466_TBCD_chr17_80828099_ENST00000355528_length(amino acids)=785AA_BP=25
MECPSCQHVSKEETPKFCSQCGERLPPAAPIAVVAVILKALTYDEKRGACSVGTNVRDAACYVCWAFARAYEPQELKPFVTAISSALVIA
AVFDRDINCRRAASAAFQENVGRQGTFPHGIDILTTADYFAVGNRSNCFLVISVFIAGFPEYTQPMIDHLVTMKISHWDGVIRELAARAL
HNLAQQAPEFSATQVFPRLLSMTLSPDLHMRHGSILACAEVAYALYKLAAQENRPVTDHLDEQAVQGLKQIHQQLYDRQLYRGLGGQLMR
QAVCVLIEKLSLSKMPFRGDTVIDGWQWLINDTLRHLHLISSHSRQQMKDAAVSALAALCSEYYMKEPGEADPAIQEELITQYLAELRNP
EEMTRCGFSLALGALPGFLLKGRLQQVLTGLRAVTHTSPEDVSFAESRRDGLKAIARICQTVGVKAGAPDEAVCGENVSQIYCALLGCMD
DYTTDSRGDVGTWVRKAAMTSLMDLTLLLARSQPELIEAHTCERIMCCVAQQASEKIDRFRAHAASVFLTLLHFDSPPIPHVPHRGELEK
LFPRSDVASVNWSAPSQAFPRITQLLGLPTYRYHVLLGLVVSLGGLTESTIRHSTQSLFEYMKGIQSDPQALGSFSGTLLQIFEDNLLNE
RVSVPLLKTLDHVLTHGCFDIFTTEEDHPFAVKLLALCKKEIKNSKDIQKLLSGIAVFCEMVQFPGDVRRQALLQLCLLLCHRFPLIRKT

--------------------------------------------------------------
>74993_74993_8_RNF213-TBCD_RNF213_chr17_78237577_ENST00000456466_TBCD_chr17_80828099_ENST00000397466_length(transcript)=1016nt_BP=240nt
CAGCGCGCGGCAGGCGGCGAGCTCGGGGGCCGCAGAAAATGAAACTGAAGCCGTGGTCACGTGACAGGACATGTAGTATATAGCAGGCTG
CCAGCGACTCCTGCTCTTGCTTCTGGATCTGCAGGGCAGTCCCAGCAGGACCCATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGAGG
AAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCCATAGCAGTTGTCGCCGTGATCCTGAAGGCGCTGACCT
ACGACGAGAAGCGGGGTGCCTGCAGCGTGGGCACCAACGTCAGGGACGCCGCCTGCTACGTGTGCTGGGCCTTCGCGCGTGCCTATGAGC
CTCAGGAGCTGAAGCCCTTTGTGACTGCAATCTCGAGTGCACTGGTGATTGCTGCGGTGTTTGACCGAGACATAAACTGCAGAAGAGCAG
CCTCTGCCGCCTTCCAGGAGAATGTGGGGAGACAGGGCACTTTCCCTCATGGTATTGATATTTTGACCACAGCTGACTATTTTGCCGTCG
GTAACAGATCCAACTGTTTCCTGGTTATAAGTGTGTTTATTGCCGGCTTTCCTGAGTACACGCAGCCAATGATAGACCACCTGGTTACCA
TGAAGATCAGCCACTGGGATGGGGTCATCCGAGAGTTGGCTGCGAGGGCGCTGCACAACCTGGCCCAGCAGGCACCCGAGTTCAGCGCCA
CGCAAGTCTTCCCGAGGCTGCTGTCCATGACACTGAGTCCAGATCTTCACATGAGGCATGGGTCGATTCTCGCCTGCGCAGAAGTTGCTT
ACGCCTTGTACAAACTTGCAGCCCAAGAGAACAGGCCCGTCACGGACCATCTGGACGAGCAGGCAGTGCAGGGCCTGAAGCAGATTCACC
AGCAGCCGTGCATCTGCAGCTGGGGTCTGATGTCTCCTGAAAGTAAAGCAGAATTTTGTGTGTGCGTCTGTCGGATTTCTCTGGGGAGAC

>74993_74993_8_RNF213-TBCD_RNF213_chr17_78237577_ENST00000456466_TBCD_chr17_80828099_ENST00000397466_length(amino acids)=314AA_BP=0
MNTLSPQRNPTDAHTKFCFTFRRHQTPAADARLLVNLLQALHCLLVQMVRDGPVLLGCKFVQGVSNFCAGENRPMPHVKIWTQCHGQQPR
EDLRGAELGCLLGQVVQRPRSQLSDDPIPVADLHGNQVVYHWLRVLRKAGNKHTYNQETVGSVTDGKIVSCGQNINTMRESALSPHILLE
GGRGCSSAVYVSVKHRSNHQCTRDCSHKGLQLLRLIGTREGPAHVAGGVPDVGAHAAGTPLLVVGQRLQDHGDNCYGGCRRQPLSALAAE

--------------------------------------------------------------
>74993_74993_9_RNF213-TBCD_RNF213_chr17_78237577_ENST00000456466_TBCD_chr17_80828099_ENST00000539345_length(transcript)=2861nt_BP=240nt
CAGCGCGCGGCAGGCGGCGAGCTCGGGGGCCGCAGAAAATGAAACTGAAGCCGTGGTCACGTGACAGGACATGTAGTATATAGCAGGCTG
CCAGCGACTCCTGCTCTTGCTTCTGGATCTGCAGGGCAGTCCCAGCAGGACCCATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGAGG
AAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCCATAGCAGTTGTCGCCGTGATCCTGAAGGCGCTGACCT
ACGACGAGAAGCGGGGTGCCTGCAGCGTGGGCACCAACGTCAGGGACGCCGCCTGCTACGTGTGCTGGGCCTTCGCGCGTGCCTATGAGC
CTCAGGAGCTGAAGCCCTTTGTGACTGCAATCTCGAGTGCACTGGTGATTGCTGCGGTGTTTGACCGAGACATAAACTGCAGAAGAGCAG
CCTCTGCCGCCTTCCAGGAGAATGTGGGGAGACAGGGCACTTTCCCTCATGGTATTGATATTTTGACCACAGCTGACTATTTTGCCGTCG
GTAACAGATCCAACTGTTTCCTGGTTATAAGTGTGTTTATTGCCGGCTTTCCTGAGTACACGCAGCCAATGATAGACCACCTGGTTACCA
TGAAGATCAGCCACTGGGATGGGGTCATCCGAGAGTTGGCTGCGAGGGCGCTGCACAACCTGGCCCAGCAGGCACCCGAGTTCAGCGCCA
CGCAAGTCTTCCCGAGGCTGCTGTCCATGACACTGAGTCCAGATCTTCACATGAGGCATGGGTCGATTCTCGCCTGCGCAGAAGTTGCTT
ACGCCTTGTACAAACTTGCAGCCCAAGAGAACAGGCCCGTCACGGACCATCTGGACGAGCAGGCAGTGCAGGGCCTGAAGCAGATTCACC
AGCAGCTCTATGATCGTCAGTTATACAGGGGTCTGGGAGGACAGCTCATGAGACAAGCAGTGTGTGTTTTAATAGAAAAGTTGTCACTTT
CCAAAATGCCCTTTAGAGGTGACACCGTAATTGATGGTTGGCAATGGCTGATAAATGACACTTTGAGACATCTCCATCTCATCTCAAGTC
ACTCCCGCCAGCAGATGAAGGATGCAGCAGTCTCGGCCCTGGCTGCTCTATGCAGTGAATATTACATGAAGGAGCCGGGGGAGGCAGATC
CCGCAATTCAGGAGGAGCTGATCACGCAGTACCTGGCTGAGCTTCGGAACCCCGAGGAGATGACTCGCTGTGGCTTCTCGTTGGCCTTGG
GCGCCCTTCCAGGCTTCCTTCTGAAAGGCCGGCTCCAGCAGGTTCTCACAGGTTTAAGAGCAGTTACCCACACTTCCCCCGAGGACGTAA
GTTTTGCTGAGTCCAGGAGAGACGGCTTGAAGGCCATTGCGAGGATTTGCCAGACTGTTGGTGTGAAAGCAGGAGCCCCAGACGAAGCTG
TGTGCGGAGAGAATGTTTCCCAGATTTACTGTGCGCTGCTGGGCTGCATGGACGACTACACCACGGACAGCAGAGGGGACGTGGGCACCT
GGGTCCGCAAGGCCGCCATGACCAGTCTGATGGATCTGACACTTCTGCTGGCTCGGAGCCAGCCTGAGCTGATCGAGGCCCATACCTGTG
AGCGCATCATGTGCTGTGTGGCCCAGCAGGCCAGTGAGAAGATTGACCGTTTCCGTGCTCACGCCGCCAGCGTGTTCCTGACGCTCCTGC
ACTTTGACAGCCCTCCCATCCCCCACGTGCCCCACCGAGGAGAACTGGAAAAGCTGTTTCCCAGGTCCGATGTGGCCTCCGTGAACTGGA
GTGCACCTTCCCAGGCCTTCCCACGCATCACCCAGCTCCTTGGGCTGCCCACCTACCGCTACCACGTCCTGCTGGGGCTAGTCGTGTCCC
TGGGCGGCTTGACGGAGTCGACGATCCGGCACTCCACCCAGAGCCTCTTTGAGTACATGAAGGGCATTCAGAGCGACCCGCAGGCCCTGG
GCAGCTTCAGCGGGACCCTTCTGCAGATCTTTGAGGACAACCTTCTGAATGAGAGGGTGTCCGTGCCGCTGCTGAAGACGCTGGACCACG
TGCTCACCCACGGCTGCTTCGACATCTTCACCACGGAGGAGGACCACCCCTTTGCTGTGAAGTTGCTTGCGCTCTGTAAGAAAGAAATCA
AGAATTCAAAAGATATCCAGAAGCTCCTGTCAGGCATCGCAGTTGACTTTCCAAGTGCGACACTCGTGTGTGTAGGCACAGTGCAGATGT
ACGCACACACACACCTCCGGCTTGGGGCCCCAGGCCCGCACTGTGCTCACGGATCTGCTCTGCCCAGGTTCTGCGAGATGGTGCAGTTCC
CCGGCGACGTGAGGAGGCAGGCCCTCCTGCAGCTGTGTCTGCTCCTCTGCCACCGTTTCCCGCTGATCCGGAAGACCACGGCCAGCCAGG
TGTACGAGACATTGCTCACCTACAGTGACGTCGTGGGCGCGGATGTGCTGGACGAGGTGGTGACTGTGCTCAGTGACACTGCGTGGGACG
CGGAGCTTGCAGTGGTGAGAGAGCAGCGCAACCGTCTGTGTGACCTTCTGGGCGTACCCAGGCCCCAGCTGGTGCCCCAGCCTGGTGCCT
GCTGAAGCCAGTCCTGGAGCCCATACCTCACCCCTGCCTGGTGAGGATGTCTTGTTCCTGAGGGAGGCCGGTGTGGAAAGCCTCGCACAG
TGGTGCCTCCAGCTGTTGAAGGGTAGCGCTGGCCCTTGGAGGCTGGCACTAGCTGACAGCTTTTCCTCTCTGCACCTGCGCTCTGGTGAC

>74993_74993_9_RNF213-TBCD_RNF213_chr17_78237577_ENST00000456466_TBCD_chr17_80828099_ENST00000539345_length(amino acids)=823AA_BP=25
MECPSCQHVSKEETPKFCSQCGERLPPAAPIAVVAVILKALTYDEKRGACSVGTNVRDAACYVCWAFARAYEPQELKPFVTAISSALVIA
AVFDRDINCRRAASAAFQENVGRQGTFPHGIDILTTADYFAVGNRSNCFLVISVFIAGFPEYTQPMIDHLVTMKISHWDGVIRELAARAL
HNLAQQAPEFSATQVFPRLLSMTLSPDLHMRHGSILACAEVAYALYKLAAQENRPVTDHLDEQAVQGLKQIHQQLYDRQLYRGLGGQLMR
QAVCVLIEKLSLSKMPFRGDTVIDGWQWLINDTLRHLHLISSHSRQQMKDAAVSALAALCSEYYMKEPGEADPAIQEELITQYLAELRNP
EEMTRCGFSLALGALPGFLLKGRLQQVLTGLRAVTHTSPEDVSFAESRRDGLKAIARICQTVGVKAGAPDEAVCGENVSQIYCALLGCMD
DYTTDSRGDVGTWVRKAAMTSLMDLTLLLARSQPELIEAHTCERIMCCVAQQASEKIDRFRAHAASVFLTLLHFDSPPIPHVPHRGELEK
LFPRSDVASVNWSAPSQAFPRITQLLGLPTYRYHVLLGLVVSLGGLTESTIRHSTQSLFEYMKGIQSDPQALGSFSGTLLQIFEDNLLNE
RVSVPLLKTLDHVLTHGCFDIFTTEEDHPFAVKLLALCKKEIKNSKDIQKLLSGIAVDFPSATLVCVGTVQMYAHTHLRLGAPGPHCAHG
SALPRFCEMVQFPGDVRRQALLQLCLLLCHRFPLIRKTTASQVYETLLTYSDVVGADVLDEVVTVLSDTAWDAELAVVREQRNRLCDLLG

--------------------------------------------------------------
>74993_74993_10_RNF213-TBCD_RNF213_chr17_78237577_ENST00000456466_TBCD_chr17_80828100_ENST00000355528_length(transcript)=2886nt_BP=240nt
CAGCGCGCGGCAGGCGGCGAGCTCGGGGGCCGCAGAAAATGAAACTGAAGCCGTGGTCACGTGACAGGACATGTAGTATATAGCAGGCTG
CCAGCGACTCCTGCTCTTGCTTCTGGATCTGCAGGGCAGTCCCAGCAGGACCCATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGAGG
AAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCCATAGCAGTTGTCGCCGTGATCCTGAAGGCGCTGACCT
ACGACGAGAAGCGGGGTGCCTGCAGCGTGGGCACCAACGTCAGGGACGCCGCCTGCTACGTGTGCTGGGCCTTCGCGCGTGCCTATGAGC
CTCAGGAGCTGAAGCCCTTTGTGACTGCAATCTCGAGTGCACTGGTGATTGCTGCGGTGTTTGACCGAGACATAAACTGCAGAAGAGCAG
CCTCTGCCGCCTTCCAGGAGAATGTGGGGAGACAGGGCACTTTCCCTCATGGTATTGATATTTTGACCACAGCTGACTATTTTGCCGTCG
GTAACAGATCCAACTGTTTCCTGGTTATAAGTGTGTTTATTGCCGGCTTTCCTGAGTACACGCAGCCAATGATAGACCACCTGGTTACCA
TGAAGATCAGCCACTGGGATGGGGTCATCCGAGAGTTGGCTGCGAGGGCGCTGCACAACCTGGCCCAGCAGGCACCCGAGTTCAGCGCCA
CGCAAGTCTTCCCGAGGCTGCTGTCCATGACACTGAGTCCAGATCTTCACATGAGGCATGGGTCGATTCTCGCCTGCGCAGAAGTTGCTT
ACGCCTTGTACAAACTTGCAGCCCAAGAGAACAGGCCCGTCACGGACCATCTGGACGAGCAGGCAGTGCAGGGCCTGAAGCAGATTCACC
AGCAGCTCTATGATCGTCAGTTATACAGGGGTCTGGGAGGACAGCTCATGAGACAAGCAGTGTGTGTTTTAATAGAAAAGTTGTCACTTT
CCAAAATGCCCTTTAGAGGTGACACCGTAATTGATGGTTGGCAATGGCTGATAAATGACACTTTGAGACATCTCCATCTCATCTCAAGTC
ACTCCCGCCAGCAGATGAAGGATGCAGCAGTCTCGGCCCTGGCTGCTCTATGCAGTGAATATTACATGAAGGAGCCGGGGGAGGCAGATC
CCGCAATTCAGGAGGAGCTGATCACGCAGTACCTGGCTGAGCTTCGGAACCCCGAGGAGATGACTCGCTGTGGCTTCTCGTTGGCCTTGG
GCGCCCTTCCAGGCTTCCTTCTGAAAGGCCGGCTCCAGCAGGTTCTCACAGGTTTAAGAGCAGTTACCCACACTTCCCCCGAGGACGTAA
GTTTTGCTGAGTCCAGGAGAGACGGCTTGAAGGCCATTGCGAGGATTTGCCAGACTGTTGGTGTGAAAGCAGGAGCCCCAGACGAAGCTG
TGTGCGGAGAGAATGTTTCCCAGATTTACTGTGCGCTGCTGGGCTGCATGGACGACTACACCACGGACAGCAGAGGGGACGTGGGCACCT
GGGTCCGCAAGGCCGCCATGACCAGTCTGATGGATCTGACACTTCTGCTGGCTCGGAGCCAGCCTGAGCTGATCGAGGCCCATACCTGTG
AGCGCATCATGTGCTGTGTGGCCCAGCAGGCCAGTGAGAAGATTGACCGTTTCCGTGCTCACGCCGCCAGCGTGTTCCTGACGCTCCTGC
ACTTTGACAGCCCTCCCATCCCCCACGTGCCCCACCGAGGAGAACTGGAAAAGCTGTTTCCCAGGTCCGATGTGGCCTCCGTGAACTGGA
GTGCACCTTCCCAGGCCTTCCCACGCATCACCCAGCTCCTTGGGCTGCCCACCTACCGCTACCACGTCCTGCTGGGGCTAGTCGTGTCCC
TGGGCGGCTTGACGGAGTCGACGATCCGGCACTCCACCCAGAGCCTCTTTGAGTACATGAAGGGCATTCAGAGCGACCCGCAGGCCCTGG
GCAGCTTCAGCGGGACCCTTCTGCAGATCTTTGAGGACAACCTTCTGAATGAGAGGGTGTCCGTGCCGCTGCTGAAGACGCTGGACCACG
TGCTCACCCACGGCTGCTTCGACATCTTCACCACGGAGGAGGACCACCCCTTTGCTGTGAAGTTGCTTGCGCTCTGTAAGAAAGAAATCA
AGAATTCAAAAGATATCCAGAAGCTCCTGTCAGGCATCGCAGTGTTCTGCGAGATGGTGCAGTTCCCCGGCGACGTGAGGAGGCAGGCCC
TCCTGCAGCTGTGTCTGCTCCTCTGCCACCGTTTCCCGCTGATCCGGAAGACCACGGCCAGCCAGGTGTACGAGACATTGCTCACCTACA
GTGACGTCGTGGGCGCGGATGTGCTGGACGAGGTGGTGACTGTGCTCAGTGACACTGCGTGGGACGCGGAGCTTGCAGTGGTGAGAGAGC
AGCGCAACCGTCTGTGTGACCTTCTGGGCGTACCCAGGCCCCAGCTGGTGCCCCAGCCTGGTGCCTGCTGAAGCCAGTCCTGGAGCCCAT
ACCTCACCCCTGCCTGGTGAGGATGTCTTGTTCCTGAGGGAGGCCGGTGTGGAAAGCCTCGCACAGTGGTGCCTCCAGCTGTTGAAGGGT
AGCGCTGGCCCTTGGAGGCTGGCACTAGCTGACAGCTTTTCCTCTCTGCACCTGCGCTCTGGTGACTTGGGGTGGACGCCTCTGCCTTCA
CTTGAACACAAATGTGCTTCCTATAAAATCATGTACCAAGAAGTTCCTGCCTTTTGTCTCTGAGCCTGATGTGTGTAGGGGTGATGGAAA
GGCTCACTGCCCAGGGGTCAGCCAGAGGGGAGGTGGGCTGCACTCCTCCTGCCTGGAGACCAGGCCCCCTTCTTGCCTGGTGCTGTCCCT

>74993_74993_10_RNF213-TBCD_RNF213_chr17_78237577_ENST00000456466_TBCD_chr17_80828100_ENST00000355528_length(amino acids)=785AA_BP=25
MECPSCQHVSKEETPKFCSQCGERLPPAAPIAVVAVILKALTYDEKRGACSVGTNVRDAACYVCWAFARAYEPQELKPFVTAISSALVIA
AVFDRDINCRRAASAAFQENVGRQGTFPHGIDILTTADYFAVGNRSNCFLVISVFIAGFPEYTQPMIDHLVTMKISHWDGVIRELAARAL
HNLAQQAPEFSATQVFPRLLSMTLSPDLHMRHGSILACAEVAYALYKLAAQENRPVTDHLDEQAVQGLKQIHQQLYDRQLYRGLGGQLMR
QAVCVLIEKLSLSKMPFRGDTVIDGWQWLINDTLRHLHLISSHSRQQMKDAAVSALAALCSEYYMKEPGEADPAIQEELITQYLAELRNP
EEMTRCGFSLALGALPGFLLKGRLQQVLTGLRAVTHTSPEDVSFAESRRDGLKAIARICQTVGVKAGAPDEAVCGENVSQIYCALLGCMD
DYTTDSRGDVGTWVRKAAMTSLMDLTLLLARSQPELIEAHTCERIMCCVAQQASEKIDRFRAHAASVFLTLLHFDSPPIPHVPHRGELEK
LFPRSDVASVNWSAPSQAFPRITQLLGLPTYRYHVLLGLVVSLGGLTESTIRHSTQSLFEYMKGIQSDPQALGSFSGTLLQIFEDNLLNE
RVSVPLLKTLDHVLTHGCFDIFTTEEDHPFAVKLLALCKKEIKNSKDIQKLLSGIAVFCEMVQFPGDVRRQALLQLCLLLCHRFPLIRKT

--------------------------------------------------------------
>74993_74993_11_RNF213-TBCD_RNF213_chr17_78237577_ENST00000456466_TBCD_chr17_80828100_ENST00000397466_length(transcript)=1016nt_BP=240nt
CAGCGCGCGGCAGGCGGCGAGCTCGGGGGCCGCAGAAAATGAAACTGAAGCCGTGGTCACGTGACAGGACATGTAGTATATAGCAGGCTG
CCAGCGACTCCTGCTCTTGCTTCTGGATCTGCAGGGCAGTCCCAGCAGGACCCATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGAGG
AAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCCATAGCAGTTGTCGCCGTGATCCTGAAGGCGCTGACCT
ACGACGAGAAGCGGGGTGCCTGCAGCGTGGGCACCAACGTCAGGGACGCCGCCTGCTACGTGTGCTGGGCCTTCGCGCGTGCCTATGAGC
CTCAGGAGCTGAAGCCCTTTGTGACTGCAATCTCGAGTGCACTGGTGATTGCTGCGGTGTTTGACCGAGACATAAACTGCAGAAGAGCAG
CCTCTGCCGCCTTCCAGGAGAATGTGGGGAGACAGGGCACTTTCCCTCATGGTATTGATATTTTGACCACAGCTGACTATTTTGCCGTCG
GTAACAGATCCAACTGTTTCCTGGTTATAAGTGTGTTTATTGCCGGCTTTCCTGAGTACACGCAGCCAATGATAGACCACCTGGTTACCA
TGAAGATCAGCCACTGGGATGGGGTCATCCGAGAGTTGGCTGCGAGGGCGCTGCACAACCTGGCCCAGCAGGCACCCGAGTTCAGCGCCA
CGCAAGTCTTCCCGAGGCTGCTGTCCATGACACTGAGTCCAGATCTTCACATGAGGCATGGGTCGATTCTCGCCTGCGCAGAAGTTGCTT
ACGCCTTGTACAAACTTGCAGCCCAAGAGAACAGGCCCGTCACGGACCATCTGGACGAGCAGGCAGTGCAGGGCCTGAAGCAGATTCACC
AGCAGCCGTGCATCTGCAGCTGGGGTCTGATGTCTCCTGAAAGTAAAGCAGAATTTTGTGTGTGCGTCTGTCGGATTTCTCTGGGGAGAC

>74993_74993_11_RNF213-TBCD_RNF213_chr17_78237577_ENST00000456466_TBCD_chr17_80828100_ENST00000397466_length(amino acids)=314AA_BP=0
MNTLSPQRNPTDAHTKFCFTFRRHQTPAADARLLVNLLQALHCLLVQMVRDGPVLLGCKFVQGVSNFCAGENRPMPHVKIWTQCHGQQPR
EDLRGAELGCLLGQVVQRPRSQLSDDPIPVADLHGNQVVYHWLRVLRKAGNKHTYNQETVGSVTDGKIVSCGQNINTMRESALSPHILLE
GGRGCSSAVYVSVKHRSNHQCTRDCSHKGLQLLRLIGTREGPAHVAGGVPDVGAHAAGTPLLVVGQRLQDHGDNCYGGCRRQPLSALAAE

--------------------------------------------------------------
>74993_74993_12_RNF213-TBCD_RNF213_chr17_78237577_ENST00000456466_TBCD_chr17_80828100_ENST00000539345_length(transcript)=2861nt_BP=240nt
CAGCGCGCGGCAGGCGGCGAGCTCGGGGGCCGCAGAAAATGAAACTGAAGCCGTGGTCACGTGACAGGACATGTAGTATATAGCAGGCTG
CCAGCGACTCCTGCTCTTGCTTCTGGATCTGCAGGGCAGTCCCAGCAGGACCCATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGAGG
AAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCCATAGCAGTTGTCGCCGTGATCCTGAAGGCGCTGACCT
ACGACGAGAAGCGGGGTGCCTGCAGCGTGGGCACCAACGTCAGGGACGCCGCCTGCTACGTGTGCTGGGCCTTCGCGCGTGCCTATGAGC
CTCAGGAGCTGAAGCCCTTTGTGACTGCAATCTCGAGTGCACTGGTGATTGCTGCGGTGTTTGACCGAGACATAAACTGCAGAAGAGCAG
CCTCTGCCGCCTTCCAGGAGAATGTGGGGAGACAGGGCACTTTCCCTCATGGTATTGATATTTTGACCACAGCTGACTATTTTGCCGTCG
GTAACAGATCCAACTGTTTCCTGGTTATAAGTGTGTTTATTGCCGGCTTTCCTGAGTACACGCAGCCAATGATAGACCACCTGGTTACCA
TGAAGATCAGCCACTGGGATGGGGTCATCCGAGAGTTGGCTGCGAGGGCGCTGCACAACCTGGCCCAGCAGGCACCCGAGTTCAGCGCCA
CGCAAGTCTTCCCGAGGCTGCTGTCCATGACACTGAGTCCAGATCTTCACATGAGGCATGGGTCGATTCTCGCCTGCGCAGAAGTTGCTT
ACGCCTTGTACAAACTTGCAGCCCAAGAGAACAGGCCCGTCACGGACCATCTGGACGAGCAGGCAGTGCAGGGCCTGAAGCAGATTCACC
AGCAGCTCTATGATCGTCAGTTATACAGGGGTCTGGGAGGACAGCTCATGAGACAAGCAGTGTGTGTTTTAATAGAAAAGTTGTCACTTT
CCAAAATGCCCTTTAGAGGTGACACCGTAATTGATGGTTGGCAATGGCTGATAAATGACACTTTGAGACATCTCCATCTCATCTCAAGTC
ACTCCCGCCAGCAGATGAAGGATGCAGCAGTCTCGGCCCTGGCTGCTCTATGCAGTGAATATTACATGAAGGAGCCGGGGGAGGCAGATC
CCGCAATTCAGGAGGAGCTGATCACGCAGTACCTGGCTGAGCTTCGGAACCCCGAGGAGATGACTCGCTGTGGCTTCTCGTTGGCCTTGG
GCGCCCTTCCAGGCTTCCTTCTGAAAGGCCGGCTCCAGCAGGTTCTCACAGGTTTAAGAGCAGTTACCCACACTTCCCCCGAGGACGTAA
GTTTTGCTGAGTCCAGGAGAGACGGCTTGAAGGCCATTGCGAGGATTTGCCAGACTGTTGGTGTGAAAGCAGGAGCCCCAGACGAAGCTG
TGTGCGGAGAGAATGTTTCCCAGATTTACTGTGCGCTGCTGGGCTGCATGGACGACTACACCACGGACAGCAGAGGGGACGTGGGCACCT
GGGTCCGCAAGGCCGCCATGACCAGTCTGATGGATCTGACACTTCTGCTGGCTCGGAGCCAGCCTGAGCTGATCGAGGCCCATACCTGTG
AGCGCATCATGTGCTGTGTGGCCCAGCAGGCCAGTGAGAAGATTGACCGTTTCCGTGCTCACGCCGCCAGCGTGTTCCTGACGCTCCTGC
ACTTTGACAGCCCTCCCATCCCCCACGTGCCCCACCGAGGAGAACTGGAAAAGCTGTTTCCCAGGTCCGATGTGGCCTCCGTGAACTGGA
GTGCACCTTCCCAGGCCTTCCCACGCATCACCCAGCTCCTTGGGCTGCCCACCTACCGCTACCACGTCCTGCTGGGGCTAGTCGTGTCCC
TGGGCGGCTTGACGGAGTCGACGATCCGGCACTCCACCCAGAGCCTCTTTGAGTACATGAAGGGCATTCAGAGCGACCCGCAGGCCCTGG
GCAGCTTCAGCGGGACCCTTCTGCAGATCTTTGAGGACAACCTTCTGAATGAGAGGGTGTCCGTGCCGCTGCTGAAGACGCTGGACCACG
TGCTCACCCACGGCTGCTTCGACATCTTCACCACGGAGGAGGACCACCCCTTTGCTGTGAAGTTGCTTGCGCTCTGTAAGAAAGAAATCA
AGAATTCAAAAGATATCCAGAAGCTCCTGTCAGGCATCGCAGTTGACTTTCCAAGTGCGACACTCGTGTGTGTAGGCACAGTGCAGATGT
ACGCACACACACACCTCCGGCTTGGGGCCCCAGGCCCGCACTGTGCTCACGGATCTGCTCTGCCCAGGTTCTGCGAGATGGTGCAGTTCC
CCGGCGACGTGAGGAGGCAGGCCCTCCTGCAGCTGTGTCTGCTCCTCTGCCACCGTTTCCCGCTGATCCGGAAGACCACGGCCAGCCAGG
TGTACGAGACATTGCTCACCTACAGTGACGTCGTGGGCGCGGATGTGCTGGACGAGGTGGTGACTGTGCTCAGTGACACTGCGTGGGACG
CGGAGCTTGCAGTGGTGAGAGAGCAGCGCAACCGTCTGTGTGACCTTCTGGGCGTACCCAGGCCCCAGCTGGTGCCCCAGCCTGGTGCCT
GCTGAAGCCAGTCCTGGAGCCCATACCTCACCCCTGCCTGGTGAGGATGTCTTGTTCCTGAGGGAGGCCGGTGTGGAAAGCCTCGCACAG
TGGTGCCTCCAGCTGTTGAAGGGTAGCGCTGGCCCTTGGAGGCTGGCACTAGCTGACAGCTTTTCCTCTCTGCACCTGCGCTCTGGTGAC

>74993_74993_12_RNF213-TBCD_RNF213_chr17_78237577_ENST00000456466_TBCD_chr17_80828100_ENST00000539345_length(amino acids)=823AA_BP=25
MECPSCQHVSKEETPKFCSQCGERLPPAAPIAVVAVILKALTYDEKRGACSVGTNVRDAACYVCWAFARAYEPQELKPFVTAISSALVIA
AVFDRDINCRRAASAAFQENVGRQGTFPHGIDILTTADYFAVGNRSNCFLVISVFIAGFPEYTQPMIDHLVTMKISHWDGVIRELAARAL
HNLAQQAPEFSATQVFPRLLSMTLSPDLHMRHGSILACAEVAYALYKLAAQENRPVTDHLDEQAVQGLKQIHQQLYDRQLYRGLGGQLMR
QAVCVLIEKLSLSKMPFRGDTVIDGWQWLINDTLRHLHLISSHSRQQMKDAAVSALAALCSEYYMKEPGEADPAIQEELITQYLAELRNP
EEMTRCGFSLALGALPGFLLKGRLQQVLTGLRAVTHTSPEDVSFAESRRDGLKAIARICQTVGVKAGAPDEAVCGENVSQIYCALLGCMD
DYTTDSRGDVGTWVRKAAMTSLMDLTLLLARSQPELIEAHTCERIMCCVAQQASEKIDRFRAHAASVFLTLLHFDSPPIPHVPHRGELEK
LFPRSDVASVNWSAPSQAFPRITQLLGLPTYRYHVLLGLVVSLGGLTESTIRHSTQSLFEYMKGIQSDPQALGSFSGTLLQIFEDNLLNE
RVSVPLLKTLDHVLTHGCFDIFTTEEDHPFAVKLLALCKKEIKNSKDIQKLLSGIAVDFPSATLVCVGTVQMYAHTHLRLGAPGPHCAHG
SALPRFCEMVQFPGDVRRQALLQLCLLLCHRFPLIRKTTASQVYETLLTYSDVVGADVLDEVVTVLSDTAWDAELAVVREQRNRLCDLLG

--------------------------------------------------------------
>74993_74993_13_RNF213-TBCD_RNF213_chr17_78237577_ENST00000508628_TBCD_chr17_80828099_ENST00000355528_length(transcript)=2888nt_BP=242nt
GACAGCGCGCGGCAGGCGGCGAGCTCGGGGGCCGCAGAAAATGAAACTGAAGCCGTGGTCACGTGACAGGACATGTAGTATATAGCAGGC
TGCCAGCGACTCCTGCTCTTGCTTCTGGATCTGCAGGGCAGTCCCAGCAGGACCCATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGA
GGAAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCCATAGCAGTTGTCGCCGTGATCCTGAAGGCGCTGAC
CTACGACGAGAAGCGGGGTGCCTGCAGCGTGGGCACCAACGTCAGGGACGCCGCCTGCTACGTGTGCTGGGCCTTCGCGCGTGCCTATGA
GCCTCAGGAGCTGAAGCCCTTTGTGACTGCAATCTCGAGTGCACTGGTGATTGCTGCGGTGTTTGACCGAGACATAAACTGCAGAAGAGC
AGCCTCTGCCGCCTTCCAGGAGAATGTGGGGAGACAGGGCACTTTCCCTCATGGTATTGATATTTTGACCACAGCTGACTATTTTGCCGT
CGGTAACAGATCCAACTGTTTCCTGGTTATAAGTGTGTTTATTGCCGGCTTTCCTGAGTACACGCAGCCAATGATAGACCACCTGGTTAC
CATGAAGATCAGCCACTGGGATGGGGTCATCCGAGAGTTGGCTGCGAGGGCGCTGCACAACCTGGCCCAGCAGGCACCCGAGTTCAGCGC
CACGCAAGTCTTCCCGAGGCTGCTGTCCATGACACTGAGTCCAGATCTTCACATGAGGCATGGGTCGATTCTCGCCTGCGCAGAAGTTGC
TTACGCCTTGTACAAACTTGCAGCCCAAGAGAACAGGCCCGTCACGGACCATCTGGACGAGCAGGCAGTGCAGGGCCTGAAGCAGATTCA
CCAGCAGCTCTATGATCGTCAGTTATACAGGGGTCTGGGAGGACAGCTCATGAGACAAGCAGTGTGTGTTTTAATAGAAAAGTTGTCACT
TTCCAAAATGCCCTTTAGAGGTGACACCGTAATTGATGGTTGGCAATGGCTGATAAATGACACTTTGAGACATCTCCATCTCATCTCAAG
TCACTCCCGCCAGCAGATGAAGGATGCAGCAGTCTCGGCCCTGGCTGCTCTATGCAGTGAATATTACATGAAGGAGCCGGGGGAGGCAGA
TCCCGCAATTCAGGAGGAGCTGATCACGCAGTACCTGGCTGAGCTTCGGAACCCCGAGGAGATGACTCGCTGTGGCTTCTCGTTGGCCTT
GGGCGCCCTTCCAGGCTTCCTTCTGAAAGGCCGGCTCCAGCAGGTTCTCACAGGTTTAAGAGCAGTTACCCACACTTCCCCCGAGGACGT
AAGTTTTGCTGAGTCCAGGAGAGACGGCTTGAAGGCCATTGCGAGGATTTGCCAGACTGTTGGTGTGAAAGCAGGAGCCCCAGACGAAGC
TGTGTGCGGAGAGAATGTTTCCCAGATTTACTGTGCGCTGCTGGGCTGCATGGACGACTACACCACGGACAGCAGAGGGGACGTGGGCAC
CTGGGTCCGCAAGGCCGCCATGACCAGTCTGATGGATCTGACACTTCTGCTGGCTCGGAGCCAGCCTGAGCTGATCGAGGCCCATACCTG
TGAGCGCATCATGTGCTGTGTGGCCCAGCAGGCCAGTGAGAAGATTGACCGTTTCCGTGCTCACGCCGCCAGCGTGTTCCTGACGCTCCT
GCACTTTGACAGCCCTCCCATCCCCCACGTGCCCCACCGAGGAGAACTGGAAAAGCTGTTTCCCAGGTCCGATGTGGCCTCCGTGAACTG
GAGTGCACCTTCCCAGGCCTTCCCACGCATCACCCAGCTCCTTGGGCTGCCCACCTACCGCTACCACGTCCTGCTGGGGCTAGTCGTGTC
CCTGGGCGGCTTGACGGAGTCGACGATCCGGCACTCCACCCAGAGCCTCTTTGAGTACATGAAGGGCATTCAGAGCGACCCGCAGGCCCT
GGGCAGCTTCAGCGGGACCCTTCTGCAGATCTTTGAGGACAACCTTCTGAATGAGAGGGTGTCCGTGCCGCTGCTGAAGACGCTGGACCA
CGTGCTCACCCACGGCTGCTTCGACATCTTCACCACGGAGGAGGACCACCCCTTTGCTGTGAAGTTGCTTGCGCTCTGTAAGAAAGAAAT
CAAGAATTCAAAAGATATCCAGAAGCTCCTGTCAGGCATCGCAGTGTTCTGCGAGATGGTGCAGTTCCCCGGCGACGTGAGGAGGCAGGC
CCTCCTGCAGCTGTGTCTGCTCCTCTGCCACCGTTTCCCGCTGATCCGGAAGACCACGGCCAGCCAGGTGTACGAGACATTGCTCACCTA
CAGTGACGTCGTGGGCGCGGATGTGCTGGACGAGGTGGTGACTGTGCTCAGTGACACTGCGTGGGACGCGGAGCTTGCAGTGGTGAGAGA
GCAGCGCAACCGTCTGTGTGACCTTCTGGGCGTACCCAGGCCCCAGCTGGTGCCCCAGCCTGGTGCCTGCTGAAGCCAGTCCTGGAGCCC
ATACCTCACCCCTGCCTGGTGAGGATGTCTTGTTCCTGAGGGAGGCCGGTGTGGAAAGCCTCGCACAGTGGTGCCTCCAGCTGTTGAAGG
GTAGCGCTGGCCCTTGGAGGCTGGCACTAGCTGACAGCTTTTCCTCTCTGCACCTGCGCTCTGGTGACTTGGGGTGGACGCCTCTGCCTT
CACTTGAACACAAATGTGCTTCCTATAAAATCATGTACCAAGAAGTTCCTGCCTTTTGTCTCTGAGCCTGATGTGTGTAGGGGTGATGGA
AAGGCTCACTGCCCAGGGGTCAGCCAGAGGGGAGGTGGGCTGCACTCCTCCTGCCTGGAGACCAGGCCCCCTTCTTGCCTGGTGCTGTCC

>74993_74993_13_RNF213-TBCD_RNF213_chr17_78237577_ENST00000508628_TBCD_chr17_80828099_ENST00000355528_length(amino acids)=785AA_BP=25
MECPSCQHVSKEETPKFCSQCGERLPPAAPIAVVAVILKALTYDEKRGACSVGTNVRDAACYVCWAFARAYEPQELKPFVTAISSALVIA
AVFDRDINCRRAASAAFQENVGRQGTFPHGIDILTTADYFAVGNRSNCFLVISVFIAGFPEYTQPMIDHLVTMKISHWDGVIRELAARAL
HNLAQQAPEFSATQVFPRLLSMTLSPDLHMRHGSILACAEVAYALYKLAAQENRPVTDHLDEQAVQGLKQIHQQLYDRQLYRGLGGQLMR
QAVCVLIEKLSLSKMPFRGDTVIDGWQWLINDTLRHLHLISSHSRQQMKDAAVSALAALCSEYYMKEPGEADPAIQEELITQYLAELRNP
EEMTRCGFSLALGALPGFLLKGRLQQVLTGLRAVTHTSPEDVSFAESRRDGLKAIARICQTVGVKAGAPDEAVCGENVSQIYCALLGCMD
DYTTDSRGDVGTWVRKAAMTSLMDLTLLLARSQPELIEAHTCERIMCCVAQQASEKIDRFRAHAASVFLTLLHFDSPPIPHVPHRGELEK
LFPRSDVASVNWSAPSQAFPRITQLLGLPTYRYHVLLGLVVSLGGLTESTIRHSTQSLFEYMKGIQSDPQALGSFSGTLLQIFEDNLLNE
RVSVPLLKTLDHVLTHGCFDIFTTEEDHPFAVKLLALCKKEIKNSKDIQKLLSGIAVFCEMVQFPGDVRRQALLQLCLLLCHRFPLIRKT

--------------------------------------------------------------
>74993_74993_14_RNF213-TBCD_RNF213_chr17_78237577_ENST00000508628_TBCD_chr17_80828099_ENST00000397466_length(transcript)=1018nt_BP=242nt
GACAGCGCGCGGCAGGCGGCGAGCTCGGGGGCCGCAGAAAATGAAACTGAAGCCGTGGTCACGTGACAGGACATGTAGTATATAGCAGGC
TGCCAGCGACTCCTGCTCTTGCTTCTGGATCTGCAGGGCAGTCCCAGCAGGACCCATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGA
GGAAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCCATAGCAGTTGTCGCCGTGATCCTGAAGGCGCTGAC
CTACGACGAGAAGCGGGGTGCCTGCAGCGTGGGCACCAACGTCAGGGACGCCGCCTGCTACGTGTGCTGGGCCTTCGCGCGTGCCTATGA
GCCTCAGGAGCTGAAGCCCTTTGTGACTGCAATCTCGAGTGCACTGGTGATTGCTGCGGTGTTTGACCGAGACATAAACTGCAGAAGAGC
AGCCTCTGCCGCCTTCCAGGAGAATGTGGGGAGACAGGGCACTTTCCCTCATGGTATTGATATTTTGACCACAGCTGACTATTTTGCCGT
CGGTAACAGATCCAACTGTTTCCTGGTTATAAGTGTGTTTATTGCCGGCTTTCCTGAGTACACGCAGCCAATGATAGACCACCTGGTTAC
CATGAAGATCAGCCACTGGGATGGGGTCATCCGAGAGTTGGCTGCGAGGGCGCTGCACAACCTGGCCCAGCAGGCACCCGAGTTCAGCGC
CACGCAAGTCTTCCCGAGGCTGCTGTCCATGACACTGAGTCCAGATCTTCACATGAGGCATGGGTCGATTCTCGCCTGCGCAGAAGTTGC
TTACGCCTTGTACAAACTTGCAGCCCAAGAGAACAGGCCCGTCACGGACCATCTGGACGAGCAGGCAGTGCAGGGCCTGAAGCAGATTCA
CCAGCAGCCGTGCATCTGCAGCTGGGGTCTGATGTCTCCTGAAAGTAAAGCAGAATTTTGTGTGTGCGTCTGTCGGATTTCTCTGGGGAG

>74993_74993_14_RNF213-TBCD_RNF213_chr17_78237577_ENST00000508628_TBCD_chr17_80828099_ENST00000397466_length(amino acids)=314AA_BP=0
MNTLSPQRNPTDAHTKFCFTFRRHQTPAADARLLVNLLQALHCLLVQMVRDGPVLLGCKFVQGVSNFCAGENRPMPHVKIWTQCHGQQPR
EDLRGAELGCLLGQVVQRPRSQLSDDPIPVADLHGNQVVYHWLRVLRKAGNKHTYNQETVGSVTDGKIVSCGQNINTMRESALSPHILLE
GGRGCSSAVYVSVKHRSNHQCTRDCSHKGLQLLRLIGTREGPAHVAGGVPDVGAHAAGTPLLVVGQRLQDHGDNCYGGCRRQPLSALAAE

--------------------------------------------------------------
>74993_74993_15_RNF213-TBCD_RNF213_chr17_78237577_ENST00000508628_TBCD_chr17_80828099_ENST00000539345_length(transcript)=2863nt_BP=242nt
GACAGCGCGCGGCAGGCGGCGAGCTCGGGGGCCGCAGAAAATGAAACTGAAGCCGTGGTCACGTGACAGGACATGTAGTATATAGCAGGC
TGCCAGCGACTCCTGCTCTTGCTTCTGGATCTGCAGGGCAGTCCCAGCAGGACCCATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGA
GGAAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCCATAGCAGTTGTCGCCGTGATCCTGAAGGCGCTGAC
CTACGACGAGAAGCGGGGTGCCTGCAGCGTGGGCACCAACGTCAGGGACGCCGCCTGCTACGTGTGCTGGGCCTTCGCGCGTGCCTATGA
GCCTCAGGAGCTGAAGCCCTTTGTGACTGCAATCTCGAGTGCACTGGTGATTGCTGCGGTGTTTGACCGAGACATAAACTGCAGAAGAGC
AGCCTCTGCCGCCTTCCAGGAGAATGTGGGGAGACAGGGCACTTTCCCTCATGGTATTGATATTTTGACCACAGCTGACTATTTTGCCGT
CGGTAACAGATCCAACTGTTTCCTGGTTATAAGTGTGTTTATTGCCGGCTTTCCTGAGTACACGCAGCCAATGATAGACCACCTGGTTAC
CATGAAGATCAGCCACTGGGATGGGGTCATCCGAGAGTTGGCTGCGAGGGCGCTGCACAACCTGGCCCAGCAGGCACCCGAGTTCAGCGC
CACGCAAGTCTTCCCGAGGCTGCTGTCCATGACACTGAGTCCAGATCTTCACATGAGGCATGGGTCGATTCTCGCCTGCGCAGAAGTTGC
TTACGCCTTGTACAAACTTGCAGCCCAAGAGAACAGGCCCGTCACGGACCATCTGGACGAGCAGGCAGTGCAGGGCCTGAAGCAGATTCA
CCAGCAGCTCTATGATCGTCAGTTATACAGGGGTCTGGGAGGACAGCTCATGAGACAAGCAGTGTGTGTTTTAATAGAAAAGTTGTCACT
TTCCAAAATGCCCTTTAGAGGTGACACCGTAATTGATGGTTGGCAATGGCTGATAAATGACACTTTGAGACATCTCCATCTCATCTCAAG
TCACTCCCGCCAGCAGATGAAGGATGCAGCAGTCTCGGCCCTGGCTGCTCTATGCAGTGAATATTACATGAAGGAGCCGGGGGAGGCAGA
TCCCGCAATTCAGGAGGAGCTGATCACGCAGTACCTGGCTGAGCTTCGGAACCCCGAGGAGATGACTCGCTGTGGCTTCTCGTTGGCCTT
GGGCGCCCTTCCAGGCTTCCTTCTGAAAGGCCGGCTCCAGCAGGTTCTCACAGGTTTAAGAGCAGTTACCCACACTTCCCCCGAGGACGT
AAGTTTTGCTGAGTCCAGGAGAGACGGCTTGAAGGCCATTGCGAGGATTTGCCAGACTGTTGGTGTGAAAGCAGGAGCCCCAGACGAAGC
TGTGTGCGGAGAGAATGTTTCCCAGATTTACTGTGCGCTGCTGGGCTGCATGGACGACTACACCACGGACAGCAGAGGGGACGTGGGCAC
CTGGGTCCGCAAGGCCGCCATGACCAGTCTGATGGATCTGACACTTCTGCTGGCTCGGAGCCAGCCTGAGCTGATCGAGGCCCATACCTG
TGAGCGCATCATGTGCTGTGTGGCCCAGCAGGCCAGTGAGAAGATTGACCGTTTCCGTGCTCACGCCGCCAGCGTGTTCCTGACGCTCCT
GCACTTTGACAGCCCTCCCATCCCCCACGTGCCCCACCGAGGAGAACTGGAAAAGCTGTTTCCCAGGTCCGATGTGGCCTCCGTGAACTG
GAGTGCACCTTCCCAGGCCTTCCCACGCATCACCCAGCTCCTTGGGCTGCCCACCTACCGCTACCACGTCCTGCTGGGGCTAGTCGTGTC
CCTGGGCGGCTTGACGGAGTCGACGATCCGGCACTCCACCCAGAGCCTCTTTGAGTACATGAAGGGCATTCAGAGCGACCCGCAGGCCCT
GGGCAGCTTCAGCGGGACCCTTCTGCAGATCTTTGAGGACAACCTTCTGAATGAGAGGGTGTCCGTGCCGCTGCTGAAGACGCTGGACCA
CGTGCTCACCCACGGCTGCTTCGACATCTTCACCACGGAGGAGGACCACCCCTTTGCTGTGAAGTTGCTTGCGCTCTGTAAGAAAGAAAT
CAAGAATTCAAAAGATATCCAGAAGCTCCTGTCAGGCATCGCAGTTGACTTTCCAAGTGCGACACTCGTGTGTGTAGGCACAGTGCAGAT
GTACGCACACACACACCTCCGGCTTGGGGCCCCAGGCCCGCACTGTGCTCACGGATCTGCTCTGCCCAGGTTCTGCGAGATGGTGCAGTT
CCCCGGCGACGTGAGGAGGCAGGCCCTCCTGCAGCTGTGTCTGCTCCTCTGCCACCGTTTCCCGCTGATCCGGAAGACCACGGCCAGCCA
GGTGTACGAGACATTGCTCACCTACAGTGACGTCGTGGGCGCGGATGTGCTGGACGAGGTGGTGACTGTGCTCAGTGACACTGCGTGGGA
CGCGGAGCTTGCAGTGGTGAGAGAGCAGCGCAACCGTCTGTGTGACCTTCTGGGCGTACCCAGGCCCCAGCTGGTGCCCCAGCCTGGTGC
CTGCTGAAGCCAGTCCTGGAGCCCATACCTCACCCCTGCCTGGTGAGGATGTCTTGTTCCTGAGGGAGGCCGGTGTGGAAAGCCTCGCAC
AGTGGTGCCTCCAGCTGTTGAAGGGTAGCGCTGGCCCTTGGAGGCTGGCACTAGCTGACAGCTTTTCCTCTCTGCACCTGCGCTCTGGTG

>74993_74993_15_RNF213-TBCD_RNF213_chr17_78237577_ENST00000508628_TBCD_chr17_80828099_ENST00000539345_length(amino acids)=823AA_BP=25
MECPSCQHVSKEETPKFCSQCGERLPPAAPIAVVAVILKALTYDEKRGACSVGTNVRDAACYVCWAFARAYEPQELKPFVTAISSALVIA
AVFDRDINCRRAASAAFQENVGRQGTFPHGIDILTTADYFAVGNRSNCFLVISVFIAGFPEYTQPMIDHLVTMKISHWDGVIRELAARAL
HNLAQQAPEFSATQVFPRLLSMTLSPDLHMRHGSILACAEVAYALYKLAAQENRPVTDHLDEQAVQGLKQIHQQLYDRQLYRGLGGQLMR
QAVCVLIEKLSLSKMPFRGDTVIDGWQWLINDTLRHLHLISSHSRQQMKDAAVSALAALCSEYYMKEPGEADPAIQEELITQYLAELRNP
EEMTRCGFSLALGALPGFLLKGRLQQVLTGLRAVTHTSPEDVSFAESRRDGLKAIARICQTVGVKAGAPDEAVCGENVSQIYCALLGCMD
DYTTDSRGDVGTWVRKAAMTSLMDLTLLLARSQPELIEAHTCERIMCCVAQQASEKIDRFRAHAASVFLTLLHFDSPPIPHVPHRGELEK
LFPRSDVASVNWSAPSQAFPRITQLLGLPTYRYHVLLGLVVSLGGLTESTIRHSTQSLFEYMKGIQSDPQALGSFSGTLLQIFEDNLLNE
RVSVPLLKTLDHVLTHGCFDIFTTEEDHPFAVKLLALCKKEIKNSKDIQKLLSGIAVDFPSATLVCVGTVQMYAHTHLRLGAPGPHCAHG
SALPRFCEMVQFPGDVRRQALLQLCLLLCHRFPLIRKTTASQVYETLLTYSDVVGADVLDEVVTVLSDTAWDAELAVVREQRNRLCDLLG

--------------------------------------------------------------
>74993_74993_16_RNF213-TBCD_RNF213_chr17_78237577_ENST00000508628_TBCD_chr17_80828100_ENST00000355528_length(transcript)=2888nt_BP=242nt
GACAGCGCGCGGCAGGCGGCGAGCTCGGGGGCCGCAGAAAATGAAACTGAAGCCGTGGTCACGTGACAGGACATGTAGTATATAGCAGGC
TGCCAGCGACTCCTGCTCTTGCTTCTGGATCTGCAGGGCAGTCCCAGCAGGACCCATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGA
GGAAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCCATAGCAGTTGTCGCCGTGATCCTGAAGGCGCTGAC
CTACGACGAGAAGCGGGGTGCCTGCAGCGTGGGCACCAACGTCAGGGACGCCGCCTGCTACGTGTGCTGGGCCTTCGCGCGTGCCTATGA
GCCTCAGGAGCTGAAGCCCTTTGTGACTGCAATCTCGAGTGCACTGGTGATTGCTGCGGTGTTTGACCGAGACATAAACTGCAGAAGAGC
AGCCTCTGCCGCCTTCCAGGAGAATGTGGGGAGACAGGGCACTTTCCCTCATGGTATTGATATTTTGACCACAGCTGACTATTTTGCCGT
CGGTAACAGATCCAACTGTTTCCTGGTTATAAGTGTGTTTATTGCCGGCTTTCCTGAGTACACGCAGCCAATGATAGACCACCTGGTTAC
CATGAAGATCAGCCACTGGGATGGGGTCATCCGAGAGTTGGCTGCGAGGGCGCTGCACAACCTGGCCCAGCAGGCACCCGAGTTCAGCGC
CACGCAAGTCTTCCCGAGGCTGCTGTCCATGACACTGAGTCCAGATCTTCACATGAGGCATGGGTCGATTCTCGCCTGCGCAGAAGTTGC
TTACGCCTTGTACAAACTTGCAGCCCAAGAGAACAGGCCCGTCACGGACCATCTGGACGAGCAGGCAGTGCAGGGCCTGAAGCAGATTCA
CCAGCAGCTCTATGATCGTCAGTTATACAGGGGTCTGGGAGGACAGCTCATGAGACAAGCAGTGTGTGTTTTAATAGAAAAGTTGTCACT
TTCCAAAATGCCCTTTAGAGGTGACACCGTAATTGATGGTTGGCAATGGCTGATAAATGACACTTTGAGACATCTCCATCTCATCTCAAG
TCACTCCCGCCAGCAGATGAAGGATGCAGCAGTCTCGGCCCTGGCTGCTCTATGCAGTGAATATTACATGAAGGAGCCGGGGGAGGCAGA
TCCCGCAATTCAGGAGGAGCTGATCACGCAGTACCTGGCTGAGCTTCGGAACCCCGAGGAGATGACTCGCTGTGGCTTCTCGTTGGCCTT
GGGCGCCCTTCCAGGCTTCCTTCTGAAAGGCCGGCTCCAGCAGGTTCTCACAGGTTTAAGAGCAGTTACCCACACTTCCCCCGAGGACGT
AAGTTTTGCTGAGTCCAGGAGAGACGGCTTGAAGGCCATTGCGAGGATTTGCCAGACTGTTGGTGTGAAAGCAGGAGCCCCAGACGAAGC
TGTGTGCGGAGAGAATGTTTCCCAGATTTACTGTGCGCTGCTGGGCTGCATGGACGACTACACCACGGACAGCAGAGGGGACGTGGGCAC
CTGGGTCCGCAAGGCCGCCATGACCAGTCTGATGGATCTGACACTTCTGCTGGCTCGGAGCCAGCCTGAGCTGATCGAGGCCCATACCTG
TGAGCGCATCATGTGCTGTGTGGCCCAGCAGGCCAGTGAGAAGATTGACCGTTTCCGTGCTCACGCCGCCAGCGTGTTCCTGACGCTCCT
GCACTTTGACAGCCCTCCCATCCCCCACGTGCCCCACCGAGGAGAACTGGAAAAGCTGTTTCCCAGGTCCGATGTGGCCTCCGTGAACTG
GAGTGCACCTTCCCAGGCCTTCCCACGCATCACCCAGCTCCTTGGGCTGCCCACCTACCGCTACCACGTCCTGCTGGGGCTAGTCGTGTC
CCTGGGCGGCTTGACGGAGTCGACGATCCGGCACTCCACCCAGAGCCTCTTTGAGTACATGAAGGGCATTCAGAGCGACCCGCAGGCCCT
GGGCAGCTTCAGCGGGACCCTTCTGCAGATCTTTGAGGACAACCTTCTGAATGAGAGGGTGTCCGTGCCGCTGCTGAAGACGCTGGACCA
CGTGCTCACCCACGGCTGCTTCGACATCTTCACCACGGAGGAGGACCACCCCTTTGCTGTGAAGTTGCTTGCGCTCTGTAAGAAAGAAAT
CAAGAATTCAAAAGATATCCAGAAGCTCCTGTCAGGCATCGCAGTGTTCTGCGAGATGGTGCAGTTCCCCGGCGACGTGAGGAGGCAGGC
CCTCCTGCAGCTGTGTCTGCTCCTCTGCCACCGTTTCCCGCTGATCCGGAAGACCACGGCCAGCCAGGTGTACGAGACATTGCTCACCTA
CAGTGACGTCGTGGGCGCGGATGTGCTGGACGAGGTGGTGACTGTGCTCAGTGACACTGCGTGGGACGCGGAGCTTGCAGTGGTGAGAGA
GCAGCGCAACCGTCTGTGTGACCTTCTGGGCGTACCCAGGCCCCAGCTGGTGCCCCAGCCTGGTGCCTGCTGAAGCCAGTCCTGGAGCCC
ATACCTCACCCCTGCCTGGTGAGGATGTCTTGTTCCTGAGGGAGGCCGGTGTGGAAAGCCTCGCACAGTGGTGCCTCCAGCTGTTGAAGG
GTAGCGCTGGCCCTTGGAGGCTGGCACTAGCTGACAGCTTTTCCTCTCTGCACCTGCGCTCTGGTGACTTGGGGTGGACGCCTCTGCCTT
CACTTGAACACAAATGTGCTTCCTATAAAATCATGTACCAAGAAGTTCCTGCCTTTTGTCTCTGAGCCTGATGTGTGTAGGGGTGATGGA
AAGGCTCACTGCCCAGGGGTCAGCCAGAGGGGAGGTGGGCTGCACTCCTCCTGCCTGGAGACCAGGCCCCCTTCTTGCCTGGTGCTGTCC

>74993_74993_16_RNF213-TBCD_RNF213_chr17_78237577_ENST00000508628_TBCD_chr17_80828100_ENST00000355528_length(amino acids)=785AA_BP=25
MECPSCQHVSKEETPKFCSQCGERLPPAAPIAVVAVILKALTYDEKRGACSVGTNVRDAACYVCWAFARAYEPQELKPFVTAISSALVIA
AVFDRDINCRRAASAAFQENVGRQGTFPHGIDILTTADYFAVGNRSNCFLVISVFIAGFPEYTQPMIDHLVTMKISHWDGVIRELAARAL
HNLAQQAPEFSATQVFPRLLSMTLSPDLHMRHGSILACAEVAYALYKLAAQENRPVTDHLDEQAVQGLKQIHQQLYDRQLYRGLGGQLMR
QAVCVLIEKLSLSKMPFRGDTVIDGWQWLINDTLRHLHLISSHSRQQMKDAAVSALAALCSEYYMKEPGEADPAIQEELITQYLAELRNP
EEMTRCGFSLALGALPGFLLKGRLQQVLTGLRAVTHTSPEDVSFAESRRDGLKAIARICQTVGVKAGAPDEAVCGENVSQIYCALLGCMD
DYTTDSRGDVGTWVRKAAMTSLMDLTLLLARSQPELIEAHTCERIMCCVAQQASEKIDRFRAHAASVFLTLLHFDSPPIPHVPHRGELEK
LFPRSDVASVNWSAPSQAFPRITQLLGLPTYRYHVLLGLVVSLGGLTESTIRHSTQSLFEYMKGIQSDPQALGSFSGTLLQIFEDNLLNE
RVSVPLLKTLDHVLTHGCFDIFTTEEDHPFAVKLLALCKKEIKNSKDIQKLLSGIAVFCEMVQFPGDVRRQALLQLCLLLCHRFPLIRKT

--------------------------------------------------------------
>74993_74993_17_RNF213-TBCD_RNF213_chr17_78237577_ENST00000508628_TBCD_chr17_80828100_ENST00000397466_length(transcript)=1018nt_BP=242nt
GACAGCGCGCGGCAGGCGGCGAGCTCGGGGGCCGCAGAAAATGAAACTGAAGCCGTGGTCACGTGACAGGACATGTAGTATATAGCAGGC
TGCCAGCGACTCCTGCTCTTGCTTCTGGATCTGCAGGGCAGTCCCAGCAGGACCCATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGA
GGAAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCCATAGCAGTTGTCGCCGTGATCCTGAAGGCGCTGAC
CTACGACGAGAAGCGGGGTGCCTGCAGCGTGGGCACCAACGTCAGGGACGCCGCCTGCTACGTGTGCTGGGCCTTCGCGCGTGCCTATGA
GCCTCAGGAGCTGAAGCCCTTTGTGACTGCAATCTCGAGTGCACTGGTGATTGCTGCGGTGTTTGACCGAGACATAAACTGCAGAAGAGC
AGCCTCTGCCGCCTTCCAGGAGAATGTGGGGAGACAGGGCACTTTCCCTCATGGTATTGATATTTTGACCACAGCTGACTATTTTGCCGT
CGGTAACAGATCCAACTGTTTCCTGGTTATAAGTGTGTTTATTGCCGGCTTTCCTGAGTACACGCAGCCAATGATAGACCACCTGGTTAC
CATGAAGATCAGCCACTGGGATGGGGTCATCCGAGAGTTGGCTGCGAGGGCGCTGCACAACCTGGCCCAGCAGGCACCCGAGTTCAGCGC
CACGCAAGTCTTCCCGAGGCTGCTGTCCATGACACTGAGTCCAGATCTTCACATGAGGCATGGGTCGATTCTCGCCTGCGCAGAAGTTGC
TTACGCCTTGTACAAACTTGCAGCCCAAGAGAACAGGCCCGTCACGGACCATCTGGACGAGCAGGCAGTGCAGGGCCTGAAGCAGATTCA
CCAGCAGCCGTGCATCTGCAGCTGGGGTCTGATGTCTCCTGAAAGTAAAGCAGAATTTTGTGTGTGCGTCTGTCGGATTTCTCTGGGGAG

>74993_74993_17_RNF213-TBCD_RNF213_chr17_78237577_ENST00000508628_TBCD_chr17_80828100_ENST00000397466_length(amino acids)=314AA_BP=0
MNTLSPQRNPTDAHTKFCFTFRRHQTPAADARLLVNLLQALHCLLVQMVRDGPVLLGCKFVQGVSNFCAGENRPMPHVKIWTQCHGQQPR
EDLRGAELGCLLGQVVQRPRSQLSDDPIPVADLHGNQVVYHWLRVLRKAGNKHTYNQETVGSVTDGKIVSCGQNINTMRESALSPHILLE
GGRGCSSAVYVSVKHRSNHQCTRDCSHKGLQLLRLIGTREGPAHVAGGVPDVGAHAAGTPLLVVGQRLQDHGDNCYGGCRRQPLSALAAE

--------------------------------------------------------------
>74993_74993_18_RNF213-TBCD_RNF213_chr17_78237577_ENST00000508628_TBCD_chr17_80828100_ENST00000539345_length(transcript)=2863nt_BP=242nt
GACAGCGCGCGGCAGGCGGCGAGCTCGGGGGCCGCAGAAAATGAAACTGAAGCCGTGGTCACGTGACAGGACATGTAGTATATAGCAGGC
TGCCAGCGACTCCTGCTCTTGCTTCTGGATCTGCAGGGCAGTCCCAGCAGGACCCATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGA
GGAAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCCATAGCAGTTGTCGCCGTGATCCTGAAGGCGCTGAC
CTACGACGAGAAGCGGGGTGCCTGCAGCGTGGGCACCAACGTCAGGGACGCCGCCTGCTACGTGTGCTGGGCCTTCGCGCGTGCCTATGA
GCCTCAGGAGCTGAAGCCCTTTGTGACTGCAATCTCGAGTGCACTGGTGATTGCTGCGGTGTTTGACCGAGACATAAACTGCAGAAGAGC
AGCCTCTGCCGCCTTCCAGGAGAATGTGGGGAGACAGGGCACTTTCCCTCATGGTATTGATATTTTGACCACAGCTGACTATTTTGCCGT
CGGTAACAGATCCAACTGTTTCCTGGTTATAAGTGTGTTTATTGCCGGCTTTCCTGAGTACACGCAGCCAATGATAGACCACCTGGTTAC
CATGAAGATCAGCCACTGGGATGGGGTCATCCGAGAGTTGGCTGCGAGGGCGCTGCACAACCTGGCCCAGCAGGCACCCGAGTTCAGCGC
CACGCAAGTCTTCCCGAGGCTGCTGTCCATGACACTGAGTCCAGATCTTCACATGAGGCATGGGTCGATTCTCGCCTGCGCAGAAGTTGC
TTACGCCTTGTACAAACTTGCAGCCCAAGAGAACAGGCCCGTCACGGACCATCTGGACGAGCAGGCAGTGCAGGGCCTGAAGCAGATTCA
CCAGCAGCTCTATGATCGTCAGTTATACAGGGGTCTGGGAGGACAGCTCATGAGACAAGCAGTGTGTGTTTTAATAGAAAAGTTGTCACT
TTCCAAAATGCCCTTTAGAGGTGACACCGTAATTGATGGTTGGCAATGGCTGATAAATGACACTTTGAGACATCTCCATCTCATCTCAAG
TCACTCCCGCCAGCAGATGAAGGATGCAGCAGTCTCGGCCCTGGCTGCTCTATGCAGTGAATATTACATGAAGGAGCCGGGGGAGGCAGA
TCCCGCAATTCAGGAGGAGCTGATCACGCAGTACCTGGCTGAGCTTCGGAACCCCGAGGAGATGACTCGCTGTGGCTTCTCGTTGGCCTT
GGGCGCCCTTCCAGGCTTCCTTCTGAAAGGCCGGCTCCAGCAGGTTCTCACAGGTTTAAGAGCAGTTACCCACACTTCCCCCGAGGACGT
AAGTTTTGCTGAGTCCAGGAGAGACGGCTTGAAGGCCATTGCGAGGATTTGCCAGACTGTTGGTGTGAAAGCAGGAGCCCCAGACGAAGC
TGTGTGCGGAGAGAATGTTTCCCAGATTTACTGTGCGCTGCTGGGCTGCATGGACGACTACACCACGGACAGCAGAGGGGACGTGGGCAC
CTGGGTCCGCAAGGCCGCCATGACCAGTCTGATGGATCTGACACTTCTGCTGGCTCGGAGCCAGCCTGAGCTGATCGAGGCCCATACCTG
TGAGCGCATCATGTGCTGTGTGGCCCAGCAGGCCAGTGAGAAGATTGACCGTTTCCGTGCTCACGCCGCCAGCGTGTTCCTGACGCTCCT
GCACTTTGACAGCCCTCCCATCCCCCACGTGCCCCACCGAGGAGAACTGGAAAAGCTGTTTCCCAGGTCCGATGTGGCCTCCGTGAACTG
GAGTGCACCTTCCCAGGCCTTCCCACGCATCACCCAGCTCCTTGGGCTGCCCACCTACCGCTACCACGTCCTGCTGGGGCTAGTCGTGTC
CCTGGGCGGCTTGACGGAGTCGACGATCCGGCACTCCACCCAGAGCCTCTTTGAGTACATGAAGGGCATTCAGAGCGACCCGCAGGCCCT
GGGCAGCTTCAGCGGGACCCTTCTGCAGATCTTTGAGGACAACCTTCTGAATGAGAGGGTGTCCGTGCCGCTGCTGAAGACGCTGGACCA
CGTGCTCACCCACGGCTGCTTCGACATCTTCACCACGGAGGAGGACCACCCCTTTGCTGTGAAGTTGCTTGCGCTCTGTAAGAAAGAAAT
CAAGAATTCAAAAGATATCCAGAAGCTCCTGTCAGGCATCGCAGTTGACTTTCCAAGTGCGACACTCGTGTGTGTAGGCACAGTGCAGAT
GTACGCACACACACACCTCCGGCTTGGGGCCCCAGGCCCGCACTGTGCTCACGGATCTGCTCTGCCCAGGTTCTGCGAGATGGTGCAGTT
CCCCGGCGACGTGAGGAGGCAGGCCCTCCTGCAGCTGTGTCTGCTCCTCTGCCACCGTTTCCCGCTGATCCGGAAGACCACGGCCAGCCA
GGTGTACGAGACATTGCTCACCTACAGTGACGTCGTGGGCGCGGATGTGCTGGACGAGGTGGTGACTGTGCTCAGTGACACTGCGTGGGA
CGCGGAGCTTGCAGTGGTGAGAGAGCAGCGCAACCGTCTGTGTGACCTTCTGGGCGTACCCAGGCCCCAGCTGGTGCCCCAGCCTGGTGC
CTGCTGAAGCCAGTCCTGGAGCCCATACCTCACCCCTGCCTGGTGAGGATGTCTTGTTCCTGAGGGAGGCCGGTGTGGAAAGCCTCGCAC
AGTGGTGCCTCCAGCTGTTGAAGGGTAGCGCTGGCCCTTGGAGGCTGGCACTAGCTGACAGCTTTTCCTCTCTGCACCTGCGCTCTGGTG

>74993_74993_18_RNF213-TBCD_RNF213_chr17_78237577_ENST00000508628_TBCD_chr17_80828100_ENST00000539345_length(amino acids)=823AA_BP=25
MECPSCQHVSKEETPKFCSQCGERLPPAAPIAVVAVILKALTYDEKRGACSVGTNVRDAACYVCWAFARAYEPQELKPFVTAISSALVIA
AVFDRDINCRRAASAAFQENVGRQGTFPHGIDILTTADYFAVGNRSNCFLVISVFIAGFPEYTQPMIDHLVTMKISHWDGVIRELAARAL
HNLAQQAPEFSATQVFPRLLSMTLSPDLHMRHGSILACAEVAYALYKLAAQENRPVTDHLDEQAVQGLKQIHQQLYDRQLYRGLGGQLMR
QAVCVLIEKLSLSKMPFRGDTVIDGWQWLINDTLRHLHLISSHSRQQMKDAAVSALAALCSEYYMKEPGEADPAIQEELITQYLAELRNP
EEMTRCGFSLALGALPGFLLKGRLQQVLTGLRAVTHTSPEDVSFAESRRDGLKAIARICQTVGVKAGAPDEAVCGENVSQIYCALLGCMD
DYTTDSRGDVGTWVRKAAMTSLMDLTLLLARSQPELIEAHTCERIMCCVAQQASEKIDRFRAHAASVFLTLLHFDSPPIPHVPHRGELEK
LFPRSDVASVNWSAPSQAFPRITQLLGLPTYRYHVLLGLVVSLGGLTESTIRHSTQSLFEYMKGIQSDPQALGSFSGTLLQIFEDNLLNE
RVSVPLLKTLDHVLTHGCFDIFTTEEDHPFAVKLLALCKKEIKNSKDIQKLLSGIAVDFPSATLVCVGTVQMYAHTHLRLGAPGPHCAHG
SALPRFCEMVQFPGDVRRQALLQLCLLLCHRFPLIRKTTASQVYETLLTYSDVVGADVLDEVVTVLSDTAWDAELAVVREQRNRLCDLLG

--------------------------------------------------------------
>74993_74993_19_RNF213-TBCD_RNF213_chr17_78237577_ENST00000582970_TBCD_chr17_80828099_ENST00000355528_length(transcript)=2886nt_BP=240nt
CAGCGCGCGGCAGGCGGCGAGCTCGGGGGCCGCAGAAAATGAAACTGAAGCCGTGGTCACGTGACAGGACATGTAGTATATAGCAGGCTG
CCAGCGACTCCTGCTCTTGCTTCTGGATCTGCAGGGCAGTCCCAGCAGGACCCATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGAGG
AAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCCATAGCAGTTGTCGCCGTGATCCTGAAGGCGCTGACCT
ACGACGAGAAGCGGGGTGCCTGCAGCGTGGGCACCAACGTCAGGGACGCCGCCTGCTACGTGTGCTGGGCCTTCGCGCGTGCCTATGAGC
CTCAGGAGCTGAAGCCCTTTGTGACTGCAATCTCGAGTGCACTGGTGATTGCTGCGGTGTTTGACCGAGACATAAACTGCAGAAGAGCAG
CCTCTGCCGCCTTCCAGGAGAATGTGGGGAGACAGGGCACTTTCCCTCATGGTATTGATATTTTGACCACAGCTGACTATTTTGCCGTCG
GTAACAGATCCAACTGTTTCCTGGTTATAAGTGTGTTTATTGCCGGCTTTCCTGAGTACACGCAGCCAATGATAGACCACCTGGTTACCA
TGAAGATCAGCCACTGGGATGGGGTCATCCGAGAGTTGGCTGCGAGGGCGCTGCACAACCTGGCCCAGCAGGCACCCGAGTTCAGCGCCA
CGCAAGTCTTCCCGAGGCTGCTGTCCATGACACTGAGTCCAGATCTTCACATGAGGCATGGGTCGATTCTCGCCTGCGCAGAAGTTGCTT
ACGCCTTGTACAAACTTGCAGCCCAAGAGAACAGGCCCGTCACGGACCATCTGGACGAGCAGGCAGTGCAGGGCCTGAAGCAGATTCACC
AGCAGCTCTATGATCGTCAGTTATACAGGGGTCTGGGAGGACAGCTCATGAGACAAGCAGTGTGTGTTTTAATAGAAAAGTTGTCACTTT
CCAAAATGCCCTTTAGAGGTGACACCGTAATTGATGGTTGGCAATGGCTGATAAATGACACTTTGAGACATCTCCATCTCATCTCAAGTC
ACTCCCGCCAGCAGATGAAGGATGCAGCAGTCTCGGCCCTGGCTGCTCTATGCAGTGAATATTACATGAAGGAGCCGGGGGAGGCAGATC
CCGCAATTCAGGAGGAGCTGATCACGCAGTACCTGGCTGAGCTTCGGAACCCCGAGGAGATGACTCGCTGTGGCTTCTCGTTGGCCTTGG
GCGCCCTTCCAGGCTTCCTTCTGAAAGGCCGGCTCCAGCAGGTTCTCACAGGTTTAAGAGCAGTTACCCACACTTCCCCCGAGGACGTAA
GTTTTGCTGAGTCCAGGAGAGACGGCTTGAAGGCCATTGCGAGGATTTGCCAGACTGTTGGTGTGAAAGCAGGAGCCCCAGACGAAGCTG
TGTGCGGAGAGAATGTTTCCCAGATTTACTGTGCGCTGCTGGGCTGCATGGACGACTACACCACGGACAGCAGAGGGGACGTGGGCACCT
GGGTCCGCAAGGCCGCCATGACCAGTCTGATGGATCTGACACTTCTGCTGGCTCGGAGCCAGCCTGAGCTGATCGAGGCCCATACCTGTG
AGCGCATCATGTGCTGTGTGGCCCAGCAGGCCAGTGAGAAGATTGACCGTTTCCGTGCTCACGCCGCCAGCGTGTTCCTGACGCTCCTGC
ACTTTGACAGCCCTCCCATCCCCCACGTGCCCCACCGAGGAGAACTGGAAAAGCTGTTTCCCAGGTCCGATGTGGCCTCCGTGAACTGGA
GTGCACCTTCCCAGGCCTTCCCACGCATCACCCAGCTCCTTGGGCTGCCCACCTACCGCTACCACGTCCTGCTGGGGCTAGTCGTGTCCC
TGGGCGGCTTGACGGAGTCGACGATCCGGCACTCCACCCAGAGCCTCTTTGAGTACATGAAGGGCATTCAGAGCGACCCGCAGGCCCTGG
GCAGCTTCAGCGGGACCCTTCTGCAGATCTTTGAGGACAACCTTCTGAATGAGAGGGTGTCCGTGCCGCTGCTGAAGACGCTGGACCACG
TGCTCACCCACGGCTGCTTCGACATCTTCACCACGGAGGAGGACCACCCCTTTGCTGTGAAGTTGCTTGCGCTCTGTAAGAAAGAAATCA
AGAATTCAAAAGATATCCAGAAGCTCCTGTCAGGCATCGCAGTGTTCTGCGAGATGGTGCAGTTCCCCGGCGACGTGAGGAGGCAGGCCC
TCCTGCAGCTGTGTCTGCTCCTCTGCCACCGTTTCCCGCTGATCCGGAAGACCACGGCCAGCCAGGTGTACGAGACATTGCTCACCTACA
GTGACGTCGTGGGCGCGGATGTGCTGGACGAGGTGGTGACTGTGCTCAGTGACACTGCGTGGGACGCGGAGCTTGCAGTGGTGAGAGAGC
AGCGCAACCGTCTGTGTGACCTTCTGGGCGTACCCAGGCCCCAGCTGGTGCCCCAGCCTGGTGCCTGCTGAAGCCAGTCCTGGAGCCCAT
ACCTCACCCCTGCCTGGTGAGGATGTCTTGTTCCTGAGGGAGGCCGGTGTGGAAAGCCTCGCACAGTGGTGCCTCCAGCTGTTGAAGGGT
AGCGCTGGCCCTTGGAGGCTGGCACTAGCTGACAGCTTTTCCTCTCTGCACCTGCGCTCTGGTGACTTGGGGTGGACGCCTCTGCCTTCA
CTTGAACACAAATGTGCTTCCTATAAAATCATGTACCAAGAAGTTCCTGCCTTTTGTCTCTGAGCCTGATGTGTGTAGGGGTGATGGAAA
GGCTCACTGCCCAGGGGTCAGCCAGAGGGGAGGTGGGCTGCACTCCTCCTGCCTGGAGACCAGGCCCCCTTCTTGCCTGGTGCTGTCCCT

>74993_74993_19_RNF213-TBCD_RNF213_chr17_78237577_ENST00000582970_TBCD_chr17_80828099_ENST00000355528_length(amino acids)=785AA_BP=25
MECPSCQHVSKEETPKFCSQCGERLPPAAPIAVVAVILKALTYDEKRGACSVGTNVRDAACYVCWAFARAYEPQELKPFVTAISSALVIA
AVFDRDINCRRAASAAFQENVGRQGTFPHGIDILTTADYFAVGNRSNCFLVISVFIAGFPEYTQPMIDHLVTMKISHWDGVIRELAARAL
HNLAQQAPEFSATQVFPRLLSMTLSPDLHMRHGSILACAEVAYALYKLAAQENRPVTDHLDEQAVQGLKQIHQQLYDRQLYRGLGGQLMR
QAVCVLIEKLSLSKMPFRGDTVIDGWQWLINDTLRHLHLISSHSRQQMKDAAVSALAALCSEYYMKEPGEADPAIQEELITQYLAELRNP
EEMTRCGFSLALGALPGFLLKGRLQQVLTGLRAVTHTSPEDVSFAESRRDGLKAIARICQTVGVKAGAPDEAVCGENVSQIYCALLGCMD
DYTTDSRGDVGTWVRKAAMTSLMDLTLLLARSQPELIEAHTCERIMCCVAQQASEKIDRFRAHAASVFLTLLHFDSPPIPHVPHRGELEK
LFPRSDVASVNWSAPSQAFPRITQLLGLPTYRYHVLLGLVVSLGGLTESTIRHSTQSLFEYMKGIQSDPQALGSFSGTLLQIFEDNLLNE
RVSVPLLKTLDHVLTHGCFDIFTTEEDHPFAVKLLALCKKEIKNSKDIQKLLSGIAVFCEMVQFPGDVRRQALLQLCLLLCHRFPLIRKT

--------------------------------------------------------------
>74993_74993_20_RNF213-TBCD_RNF213_chr17_78237577_ENST00000582970_TBCD_chr17_80828099_ENST00000397466_length(transcript)=1016nt_BP=240nt
CAGCGCGCGGCAGGCGGCGAGCTCGGGGGCCGCAGAAAATGAAACTGAAGCCGTGGTCACGTGACAGGACATGTAGTATATAGCAGGCTG
CCAGCGACTCCTGCTCTTGCTTCTGGATCTGCAGGGCAGTCCCAGCAGGACCCATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGAGG
AAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCCATAGCAGTTGTCGCCGTGATCCTGAAGGCGCTGACCT
ACGACGAGAAGCGGGGTGCCTGCAGCGTGGGCACCAACGTCAGGGACGCCGCCTGCTACGTGTGCTGGGCCTTCGCGCGTGCCTATGAGC
CTCAGGAGCTGAAGCCCTTTGTGACTGCAATCTCGAGTGCACTGGTGATTGCTGCGGTGTTTGACCGAGACATAAACTGCAGAAGAGCAG
CCTCTGCCGCCTTCCAGGAGAATGTGGGGAGACAGGGCACTTTCCCTCATGGTATTGATATTTTGACCACAGCTGACTATTTTGCCGTCG
GTAACAGATCCAACTGTTTCCTGGTTATAAGTGTGTTTATTGCCGGCTTTCCTGAGTACACGCAGCCAATGATAGACCACCTGGTTACCA
TGAAGATCAGCCACTGGGATGGGGTCATCCGAGAGTTGGCTGCGAGGGCGCTGCACAACCTGGCCCAGCAGGCACCCGAGTTCAGCGCCA
CGCAAGTCTTCCCGAGGCTGCTGTCCATGACACTGAGTCCAGATCTTCACATGAGGCATGGGTCGATTCTCGCCTGCGCAGAAGTTGCTT
ACGCCTTGTACAAACTTGCAGCCCAAGAGAACAGGCCCGTCACGGACCATCTGGACGAGCAGGCAGTGCAGGGCCTGAAGCAGATTCACC
AGCAGCCGTGCATCTGCAGCTGGGGTCTGATGTCTCCTGAAAGTAAAGCAGAATTTTGTGTGTGCGTCTGTCGGATTTCTCTGGGGAGAC

>74993_74993_20_RNF213-TBCD_RNF213_chr17_78237577_ENST00000582970_TBCD_chr17_80828099_ENST00000397466_length(amino acids)=314AA_BP=0
MNTLSPQRNPTDAHTKFCFTFRRHQTPAADARLLVNLLQALHCLLVQMVRDGPVLLGCKFVQGVSNFCAGENRPMPHVKIWTQCHGQQPR
EDLRGAELGCLLGQVVQRPRSQLSDDPIPVADLHGNQVVYHWLRVLRKAGNKHTYNQETVGSVTDGKIVSCGQNINTMRESALSPHILLE
GGRGCSSAVYVSVKHRSNHQCTRDCSHKGLQLLRLIGTREGPAHVAGGVPDVGAHAAGTPLLVVGQRLQDHGDNCYGGCRRQPLSALAAE

--------------------------------------------------------------
>74993_74993_21_RNF213-TBCD_RNF213_chr17_78237577_ENST00000582970_TBCD_chr17_80828099_ENST00000539345_length(transcript)=2861nt_BP=240nt
CAGCGCGCGGCAGGCGGCGAGCTCGGGGGCCGCAGAAAATGAAACTGAAGCCGTGGTCACGTGACAGGACATGTAGTATATAGCAGGCTG
CCAGCGACTCCTGCTCTTGCTTCTGGATCTGCAGGGCAGTCCCAGCAGGACCCATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGAGG
AAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCCATAGCAGTTGTCGCCGTGATCCTGAAGGCGCTGACCT
ACGACGAGAAGCGGGGTGCCTGCAGCGTGGGCACCAACGTCAGGGACGCCGCCTGCTACGTGTGCTGGGCCTTCGCGCGTGCCTATGAGC
CTCAGGAGCTGAAGCCCTTTGTGACTGCAATCTCGAGTGCACTGGTGATTGCTGCGGTGTTTGACCGAGACATAAACTGCAGAAGAGCAG
CCTCTGCCGCCTTCCAGGAGAATGTGGGGAGACAGGGCACTTTCCCTCATGGTATTGATATTTTGACCACAGCTGACTATTTTGCCGTCG
GTAACAGATCCAACTGTTTCCTGGTTATAAGTGTGTTTATTGCCGGCTTTCCTGAGTACACGCAGCCAATGATAGACCACCTGGTTACCA
TGAAGATCAGCCACTGGGATGGGGTCATCCGAGAGTTGGCTGCGAGGGCGCTGCACAACCTGGCCCAGCAGGCACCCGAGTTCAGCGCCA
CGCAAGTCTTCCCGAGGCTGCTGTCCATGACACTGAGTCCAGATCTTCACATGAGGCATGGGTCGATTCTCGCCTGCGCAGAAGTTGCTT
ACGCCTTGTACAAACTTGCAGCCCAAGAGAACAGGCCCGTCACGGACCATCTGGACGAGCAGGCAGTGCAGGGCCTGAAGCAGATTCACC
AGCAGCTCTATGATCGTCAGTTATACAGGGGTCTGGGAGGACAGCTCATGAGACAAGCAGTGTGTGTTTTAATAGAAAAGTTGTCACTTT
CCAAAATGCCCTTTAGAGGTGACACCGTAATTGATGGTTGGCAATGGCTGATAAATGACACTTTGAGACATCTCCATCTCATCTCAAGTC
ACTCCCGCCAGCAGATGAAGGATGCAGCAGTCTCGGCCCTGGCTGCTCTATGCAGTGAATATTACATGAAGGAGCCGGGGGAGGCAGATC
CCGCAATTCAGGAGGAGCTGATCACGCAGTACCTGGCTGAGCTTCGGAACCCCGAGGAGATGACTCGCTGTGGCTTCTCGTTGGCCTTGG
GCGCCCTTCCAGGCTTCCTTCTGAAAGGCCGGCTCCAGCAGGTTCTCACAGGTTTAAGAGCAGTTACCCACACTTCCCCCGAGGACGTAA
GTTTTGCTGAGTCCAGGAGAGACGGCTTGAAGGCCATTGCGAGGATTTGCCAGACTGTTGGTGTGAAAGCAGGAGCCCCAGACGAAGCTG
TGTGCGGAGAGAATGTTTCCCAGATTTACTGTGCGCTGCTGGGCTGCATGGACGACTACACCACGGACAGCAGAGGGGACGTGGGCACCT
GGGTCCGCAAGGCCGCCATGACCAGTCTGATGGATCTGACACTTCTGCTGGCTCGGAGCCAGCCTGAGCTGATCGAGGCCCATACCTGTG
AGCGCATCATGTGCTGTGTGGCCCAGCAGGCCAGTGAGAAGATTGACCGTTTCCGTGCTCACGCCGCCAGCGTGTTCCTGACGCTCCTGC
ACTTTGACAGCCCTCCCATCCCCCACGTGCCCCACCGAGGAGAACTGGAAAAGCTGTTTCCCAGGTCCGATGTGGCCTCCGTGAACTGGA
GTGCACCTTCCCAGGCCTTCCCACGCATCACCCAGCTCCTTGGGCTGCCCACCTACCGCTACCACGTCCTGCTGGGGCTAGTCGTGTCCC
TGGGCGGCTTGACGGAGTCGACGATCCGGCACTCCACCCAGAGCCTCTTTGAGTACATGAAGGGCATTCAGAGCGACCCGCAGGCCCTGG
GCAGCTTCAGCGGGACCCTTCTGCAGATCTTTGAGGACAACCTTCTGAATGAGAGGGTGTCCGTGCCGCTGCTGAAGACGCTGGACCACG
TGCTCACCCACGGCTGCTTCGACATCTTCACCACGGAGGAGGACCACCCCTTTGCTGTGAAGTTGCTTGCGCTCTGTAAGAAAGAAATCA
AGAATTCAAAAGATATCCAGAAGCTCCTGTCAGGCATCGCAGTTGACTTTCCAAGTGCGACACTCGTGTGTGTAGGCACAGTGCAGATGT
ACGCACACACACACCTCCGGCTTGGGGCCCCAGGCCCGCACTGTGCTCACGGATCTGCTCTGCCCAGGTTCTGCGAGATGGTGCAGTTCC
CCGGCGACGTGAGGAGGCAGGCCCTCCTGCAGCTGTGTCTGCTCCTCTGCCACCGTTTCCCGCTGATCCGGAAGACCACGGCCAGCCAGG
TGTACGAGACATTGCTCACCTACAGTGACGTCGTGGGCGCGGATGTGCTGGACGAGGTGGTGACTGTGCTCAGTGACACTGCGTGGGACG
CGGAGCTTGCAGTGGTGAGAGAGCAGCGCAACCGTCTGTGTGACCTTCTGGGCGTACCCAGGCCCCAGCTGGTGCCCCAGCCTGGTGCCT
GCTGAAGCCAGTCCTGGAGCCCATACCTCACCCCTGCCTGGTGAGGATGTCTTGTTCCTGAGGGAGGCCGGTGTGGAAAGCCTCGCACAG
TGGTGCCTCCAGCTGTTGAAGGGTAGCGCTGGCCCTTGGAGGCTGGCACTAGCTGACAGCTTTTCCTCTCTGCACCTGCGCTCTGGTGAC

>74993_74993_21_RNF213-TBCD_RNF213_chr17_78237577_ENST00000582970_TBCD_chr17_80828099_ENST00000539345_length(amino acids)=823AA_BP=25
MECPSCQHVSKEETPKFCSQCGERLPPAAPIAVVAVILKALTYDEKRGACSVGTNVRDAACYVCWAFARAYEPQELKPFVTAISSALVIA
AVFDRDINCRRAASAAFQENVGRQGTFPHGIDILTTADYFAVGNRSNCFLVISVFIAGFPEYTQPMIDHLVTMKISHWDGVIRELAARAL
HNLAQQAPEFSATQVFPRLLSMTLSPDLHMRHGSILACAEVAYALYKLAAQENRPVTDHLDEQAVQGLKQIHQQLYDRQLYRGLGGQLMR
QAVCVLIEKLSLSKMPFRGDTVIDGWQWLINDTLRHLHLISSHSRQQMKDAAVSALAALCSEYYMKEPGEADPAIQEELITQYLAELRNP
EEMTRCGFSLALGALPGFLLKGRLQQVLTGLRAVTHTSPEDVSFAESRRDGLKAIARICQTVGVKAGAPDEAVCGENVSQIYCALLGCMD
DYTTDSRGDVGTWVRKAAMTSLMDLTLLLARSQPELIEAHTCERIMCCVAQQASEKIDRFRAHAASVFLTLLHFDSPPIPHVPHRGELEK
LFPRSDVASVNWSAPSQAFPRITQLLGLPTYRYHVLLGLVVSLGGLTESTIRHSTQSLFEYMKGIQSDPQALGSFSGTLLQIFEDNLLNE
RVSVPLLKTLDHVLTHGCFDIFTTEEDHPFAVKLLALCKKEIKNSKDIQKLLSGIAVDFPSATLVCVGTVQMYAHTHLRLGAPGPHCAHG
SALPRFCEMVQFPGDVRRQALLQLCLLLCHRFPLIRKTTASQVYETLLTYSDVVGADVLDEVVTVLSDTAWDAELAVVREQRNRLCDLLG

--------------------------------------------------------------
>74993_74993_22_RNF213-TBCD_RNF213_chr17_78237577_ENST00000582970_TBCD_chr17_80828100_ENST00000355528_length(transcript)=2886nt_BP=240nt
CAGCGCGCGGCAGGCGGCGAGCTCGGGGGCCGCAGAAAATGAAACTGAAGCCGTGGTCACGTGACAGGACATGTAGTATATAGCAGGCTG
CCAGCGACTCCTGCTCTTGCTTCTGGATCTGCAGGGCAGTCCCAGCAGGACCCATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGAGG
AAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCCATAGCAGTTGTCGCCGTGATCCTGAAGGCGCTGACCT
ACGACGAGAAGCGGGGTGCCTGCAGCGTGGGCACCAACGTCAGGGACGCCGCCTGCTACGTGTGCTGGGCCTTCGCGCGTGCCTATGAGC
CTCAGGAGCTGAAGCCCTTTGTGACTGCAATCTCGAGTGCACTGGTGATTGCTGCGGTGTTTGACCGAGACATAAACTGCAGAAGAGCAG
CCTCTGCCGCCTTCCAGGAGAATGTGGGGAGACAGGGCACTTTCCCTCATGGTATTGATATTTTGACCACAGCTGACTATTTTGCCGTCG
GTAACAGATCCAACTGTTTCCTGGTTATAAGTGTGTTTATTGCCGGCTTTCCTGAGTACACGCAGCCAATGATAGACCACCTGGTTACCA
TGAAGATCAGCCACTGGGATGGGGTCATCCGAGAGTTGGCTGCGAGGGCGCTGCACAACCTGGCCCAGCAGGCACCCGAGTTCAGCGCCA
CGCAAGTCTTCCCGAGGCTGCTGTCCATGACACTGAGTCCAGATCTTCACATGAGGCATGGGTCGATTCTCGCCTGCGCAGAAGTTGCTT
ACGCCTTGTACAAACTTGCAGCCCAAGAGAACAGGCCCGTCACGGACCATCTGGACGAGCAGGCAGTGCAGGGCCTGAAGCAGATTCACC
AGCAGCTCTATGATCGTCAGTTATACAGGGGTCTGGGAGGACAGCTCATGAGACAAGCAGTGTGTGTTTTAATAGAAAAGTTGTCACTTT
CCAAAATGCCCTTTAGAGGTGACACCGTAATTGATGGTTGGCAATGGCTGATAAATGACACTTTGAGACATCTCCATCTCATCTCAAGTC
ACTCCCGCCAGCAGATGAAGGATGCAGCAGTCTCGGCCCTGGCTGCTCTATGCAGTGAATATTACATGAAGGAGCCGGGGGAGGCAGATC
CCGCAATTCAGGAGGAGCTGATCACGCAGTACCTGGCTGAGCTTCGGAACCCCGAGGAGATGACTCGCTGTGGCTTCTCGTTGGCCTTGG
GCGCCCTTCCAGGCTTCCTTCTGAAAGGCCGGCTCCAGCAGGTTCTCACAGGTTTAAGAGCAGTTACCCACACTTCCCCCGAGGACGTAA
GTTTTGCTGAGTCCAGGAGAGACGGCTTGAAGGCCATTGCGAGGATTTGCCAGACTGTTGGTGTGAAAGCAGGAGCCCCAGACGAAGCTG
TGTGCGGAGAGAATGTTTCCCAGATTTACTGTGCGCTGCTGGGCTGCATGGACGACTACACCACGGACAGCAGAGGGGACGTGGGCACCT
GGGTCCGCAAGGCCGCCATGACCAGTCTGATGGATCTGACACTTCTGCTGGCTCGGAGCCAGCCTGAGCTGATCGAGGCCCATACCTGTG
AGCGCATCATGTGCTGTGTGGCCCAGCAGGCCAGTGAGAAGATTGACCGTTTCCGTGCTCACGCCGCCAGCGTGTTCCTGACGCTCCTGC
ACTTTGACAGCCCTCCCATCCCCCACGTGCCCCACCGAGGAGAACTGGAAAAGCTGTTTCCCAGGTCCGATGTGGCCTCCGTGAACTGGA
GTGCACCTTCCCAGGCCTTCCCACGCATCACCCAGCTCCTTGGGCTGCCCACCTACCGCTACCACGTCCTGCTGGGGCTAGTCGTGTCCC
TGGGCGGCTTGACGGAGTCGACGATCCGGCACTCCACCCAGAGCCTCTTTGAGTACATGAAGGGCATTCAGAGCGACCCGCAGGCCCTGG
GCAGCTTCAGCGGGACCCTTCTGCAGATCTTTGAGGACAACCTTCTGAATGAGAGGGTGTCCGTGCCGCTGCTGAAGACGCTGGACCACG
TGCTCACCCACGGCTGCTTCGACATCTTCACCACGGAGGAGGACCACCCCTTTGCTGTGAAGTTGCTTGCGCTCTGTAAGAAAGAAATCA
AGAATTCAAAAGATATCCAGAAGCTCCTGTCAGGCATCGCAGTGTTCTGCGAGATGGTGCAGTTCCCCGGCGACGTGAGGAGGCAGGCCC
TCCTGCAGCTGTGTCTGCTCCTCTGCCACCGTTTCCCGCTGATCCGGAAGACCACGGCCAGCCAGGTGTACGAGACATTGCTCACCTACA
GTGACGTCGTGGGCGCGGATGTGCTGGACGAGGTGGTGACTGTGCTCAGTGACACTGCGTGGGACGCGGAGCTTGCAGTGGTGAGAGAGC
AGCGCAACCGTCTGTGTGACCTTCTGGGCGTACCCAGGCCCCAGCTGGTGCCCCAGCCTGGTGCCTGCTGAAGCCAGTCCTGGAGCCCAT
ACCTCACCCCTGCCTGGTGAGGATGTCTTGTTCCTGAGGGAGGCCGGTGTGGAAAGCCTCGCACAGTGGTGCCTCCAGCTGTTGAAGGGT
AGCGCTGGCCCTTGGAGGCTGGCACTAGCTGACAGCTTTTCCTCTCTGCACCTGCGCTCTGGTGACTTGGGGTGGACGCCTCTGCCTTCA
CTTGAACACAAATGTGCTTCCTATAAAATCATGTACCAAGAAGTTCCTGCCTTTTGTCTCTGAGCCTGATGTGTGTAGGGGTGATGGAAA
GGCTCACTGCCCAGGGGTCAGCCAGAGGGGAGGTGGGCTGCACTCCTCCTGCCTGGAGACCAGGCCCCCTTCTTGCCTGGTGCTGTCCCT

>74993_74993_22_RNF213-TBCD_RNF213_chr17_78237577_ENST00000582970_TBCD_chr17_80828100_ENST00000355528_length(amino acids)=785AA_BP=25
MECPSCQHVSKEETPKFCSQCGERLPPAAPIAVVAVILKALTYDEKRGACSVGTNVRDAACYVCWAFARAYEPQELKPFVTAISSALVIA
AVFDRDINCRRAASAAFQENVGRQGTFPHGIDILTTADYFAVGNRSNCFLVISVFIAGFPEYTQPMIDHLVTMKISHWDGVIRELAARAL
HNLAQQAPEFSATQVFPRLLSMTLSPDLHMRHGSILACAEVAYALYKLAAQENRPVTDHLDEQAVQGLKQIHQQLYDRQLYRGLGGQLMR
QAVCVLIEKLSLSKMPFRGDTVIDGWQWLINDTLRHLHLISSHSRQQMKDAAVSALAALCSEYYMKEPGEADPAIQEELITQYLAELRNP
EEMTRCGFSLALGALPGFLLKGRLQQVLTGLRAVTHTSPEDVSFAESRRDGLKAIARICQTVGVKAGAPDEAVCGENVSQIYCALLGCMD
DYTTDSRGDVGTWVRKAAMTSLMDLTLLLARSQPELIEAHTCERIMCCVAQQASEKIDRFRAHAASVFLTLLHFDSPPIPHVPHRGELEK
LFPRSDVASVNWSAPSQAFPRITQLLGLPTYRYHVLLGLVVSLGGLTESTIRHSTQSLFEYMKGIQSDPQALGSFSGTLLQIFEDNLLNE
RVSVPLLKTLDHVLTHGCFDIFTTEEDHPFAVKLLALCKKEIKNSKDIQKLLSGIAVFCEMVQFPGDVRRQALLQLCLLLCHRFPLIRKT

--------------------------------------------------------------
>74993_74993_23_RNF213-TBCD_RNF213_chr17_78237577_ENST00000582970_TBCD_chr17_80828100_ENST00000397466_length(transcript)=1016nt_BP=240nt
CAGCGCGCGGCAGGCGGCGAGCTCGGGGGCCGCAGAAAATGAAACTGAAGCCGTGGTCACGTGACAGGACATGTAGTATATAGCAGGCTG
CCAGCGACTCCTGCTCTTGCTTCTGGATCTGCAGGGCAGTCCCAGCAGGACCCATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGAGG
AAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCCATAGCAGTTGTCGCCGTGATCCTGAAGGCGCTGACCT
ACGACGAGAAGCGGGGTGCCTGCAGCGTGGGCACCAACGTCAGGGACGCCGCCTGCTACGTGTGCTGGGCCTTCGCGCGTGCCTATGAGC
CTCAGGAGCTGAAGCCCTTTGTGACTGCAATCTCGAGTGCACTGGTGATTGCTGCGGTGTTTGACCGAGACATAAACTGCAGAAGAGCAG
CCTCTGCCGCCTTCCAGGAGAATGTGGGGAGACAGGGCACTTTCCCTCATGGTATTGATATTTTGACCACAGCTGACTATTTTGCCGTCG
GTAACAGATCCAACTGTTTCCTGGTTATAAGTGTGTTTATTGCCGGCTTTCCTGAGTACACGCAGCCAATGATAGACCACCTGGTTACCA
TGAAGATCAGCCACTGGGATGGGGTCATCCGAGAGTTGGCTGCGAGGGCGCTGCACAACCTGGCCCAGCAGGCACCCGAGTTCAGCGCCA
CGCAAGTCTTCCCGAGGCTGCTGTCCATGACACTGAGTCCAGATCTTCACATGAGGCATGGGTCGATTCTCGCCTGCGCAGAAGTTGCTT
ACGCCTTGTACAAACTTGCAGCCCAAGAGAACAGGCCCGTCACGGACCATCTGGACGAGCAGGCAGTGCAGGGCCTGAAGCAGATTCACC
AGCAGCCGTGCATCTGCAGCTGGGGTCTGATGTCTCCTGAAAGTAAAGCAGAATTTTGTGTGTGCGTCTGTCGGATTTCTCTGGGGAGAC

>74993_74993_23_RNF213-TBCD_RNF213_chr17_78237577_ENST00000582970_TBCD_chr17_80828100_ENST00000397466_length(amino acids)=314AA_BP=0
MNTLSPQRNPTDAHTKFCFTFRRHQTPAADARLLVNLLQALHCLLVQMVRDGPVLLGCKFVQGVSNFCAGENRPMPHVKIWTQCHGQQPR
EDLRGAELGCLLGQVVQRPRSQLSDDPIPVADLHGNQVVYHWLRVLRKAGNKHTYNQETVGSVTDGKIVSCGQNINTMRESALSPHILLE
GGRGCSSAVYVSVKHRSNHQCTRDCSHKGLQLLRLIGTREGPAHVAGGVPDVGAHAAGTPLLVVGQRLQDHGDNCYGGCRRQPLSALAAE

--------------------------------------------------------------
>74993_74993_24_RNF213-TBCD_RNF213_chr17_78237577_ENST00000582970_TBCD_chr17_80828100_ENST00000539345_length(transcript)=2861nt_BP=240nt
CAGCGCGCGGCAGGCGGCGAGCTCGGGGGCCGCAGAAAATGAAACTGAAGCCGTGGTCACGTGACAGGACATGTAGTATATAGCAGGCTG
CCAGCGACTCCTGCTCTTGCTTCTGGATCTGCAGGGCAGTCCCAGCAGGACCCATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGAGG
AAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCCATAGCAGTTGTCGCCGTGATCCTGAAGGCGCTGACCT
ACGACGAGAAGCGGGGTGCCTGCAGCGTGGGCACCAACGTCAGGGACGCCGCCTGCTACGTGTGCTGGGCCTTCGCGCGTGCCTATGAGC
CTCAGGAGCTGAAGCCCTTTGTGACTGCAATCTCGAGTGCACTGGTGATTGCTGCGGTGTTTGACCGAGACATAAACTGCAGAAGAGCAG
CCTCTGCCGCCTTCCAGGAGAATGTGGGGAGACAGGGCACTTTCCCTCATGGTATTGATATTTTGACCACAGCTGACTATTTTGCCGTCG
GTAACAGATCCAACTGTTTCCTGGTTATAAGTGTGTTTATTGCCGGCTTTCCTGAGTACACGCAGCCAATGATAGACCACCTGGTTACCA
TGAAGATCAGCCACTGGGATGGGGTCATCCGAGAGTTGGCTGCGAGGGCGCTGCACAACCTGGCCCAGCAGGCACCCGAGTTCAGCGCCA
CGCAAGTCTTCCCGAGGCTGCTGTCCATGACACTGAGTCCAGATCTTCACATGAGGCATGGGTCGATTCTCGCCTGCGCAGAAGTTGCTT
ACGCCTTGTACAAACTTGCAGCCCAAGAGAACAGGCCCGTCACGGACCATCTGGACGAGCAGGCAGTGCAGGGCCTGAAGCAGATTCACC
AGCAGCTCTATGATCGTCAGTTATACAGGGGTCTGGGAGGACAGCTCATGAGACAAGCAGTGTGTGTTTTAATAGAAAAGTTGTCACTTT
CCAAAATGCCCTTTAGAGGTGACACCGTAATTGATGGTTGGCAATGGCTGATAAATGACACTTTGAGACATCTCCATCTCATCTCAAGTC
ACTCCCGCCAGCAGATGAAGGATGCAGCAGTCTCGGCCCTGGCTGCTCTATGCAGTGAATATTACATGAAGGAGCCGGGGGAGGCAGATC
CCGCAATTCAGGAGGAGCTGATCACGCAGTACCTGGCTGAGCTTCGGAACCCCGAGGAGATGACTCGCTGTGGCTTCTCGTTGGCCTTGG
GCGCCCTTCCAGGCTTCCTTCTGAAAGGCCGGCTCCAGCAGGTTCTCACAGGTTTAAGAGCAGTTACCCACACTTCCCCCGAGGACGTAA
GTTTTGCTGAGTCCAGGAGAGACGGCTTGAAGGCCATTGCGAGGATTTGCCAGACTGTTGGTGTGAAAGCAGGAGCCCCAGACGAAGCTG
TGTGCGGAGAGAATGTTTCCCAGATTTACTGTGCGCTGCTGGGCTGCATGGACGACTACACCACGGACAGCAGAGGGGACGTGGGCACCT
GGGTCCGCAAGGCCGCCATGACCAGTCTGATGGATCTGACACTTCTGCTGGCTCGGAGCCAGCCTGAGCTGATCGAGGCCCATACCTGTG
AGCGCATCATGTGCTGTGTGGCCCAGCAGGCCAGTGAGAAGATTGACCGTTTCCGTGCTCACGCCGCCAGCGTGTTCCTGACGCTCCTGC
ACTTTGACAGCCCTCCCATCCCCCACGTGCCCCACCGAGGAGAACTGGAAAAGCTGTTTCCCAGGTCCGATGTGGCCTCCGTGAACTGGA
GTGCACCTTCCCAGGCCTTCCCACGCATCACCCAGCTCCTTGGGCTGCCCACCTACCGCTACCACGTCCTGCTGGGGCTAGTCGTGTCCC
TGGGCGGCTTGACGGAGTCGACGATCCGGCACTCCACCCAGAGCCTCTTTGAGTACATGAAGGGCATTCAGAGCGACCCGCAGGCCCTGG
GCAGCTTCAGCGGGACCCTTCTGCAGATCTTTGAGGACAACCTTCTGAATGAGAGGGTGTCCGTGCCGCTGCTGAAGACGCTGGACCACG
TGCTCACCCACGGCTGCTTCGACATCTTCACCACGGAGGAGGACCACCCCTTTGCTGTGAAGTTGCTTGCGCTCTGTAAGAAAGAAATCA
AGAATTCAAAAGATATCCAGAAGCTCCTGTCAGGCATCGCAGTTGACTTTCCAAGTGCGACACTCGTGTGTGTAGGCACAGTGCAGATGT
ACGCACACACACACCTCCGGCTTGGGGCCCCAGGCCCGCACTGTGCTCACGGATCTGCTCTGCCCAGGTTCTGCGAGATGGTGCAGTTCC
CCGGCGACGTGAGGAGGCAGGCCCTCCTGCAGCTGTGTCTGCTCCTCTGCCACCGTTTCCCGCTGATCCGGAAGACCACGGCCAGCCAGG
TGTACGAGACATTGCTCACCTACAGTGACGTCGTGGGCGCGGATGTGCTGGACGAGGTGGTGACTGTGCTCAGTGACACTGCGTGGGACG
CGGAGCTTGCAGTGGTGAGAGAGCAGCGCAACCGTCTGTGTGACCTTCTGGGCGTACCCAGGCCCCAGCTGGTGCCCCAGCCTGGTGCCT
GCTGAAGCCAGTCCTGGAGCCCATACCTCACCCCTGCCTGGTGAGGATGTCTTGTTCCTGAGGGAGGCCGGTGTGGAAAGCCTCGCACAG
TGGTGCCTCCAGCTGTTGAAGGGTAGCGCTGGCCCTTGGAGGCTGGCACTAGCTGACAGCTTTTCCTCTCTGCACCTGCGCTCTGGTGAC

>74993_74993_24_RNF213-TBCD_RNF213_chr17_78237577_ENST00000582970_TBCD_chr17_80828100_ENST00000539345_length(amino acids)=823AA_BP=25
MECPSCQHVSKEETPKFCSQCGERLPPAAPIAVVAVILKALTYDEKRGACSVGTNVRDAACYVCWAFARAYEPQELKPFVTAISSALVIA
AVFDRDINCRRAASAAFQENVGRQGTFPHGIDILTTADYFAVGNRSNCFLVISVFIAGFPEYTQPMIDHLVTMKISHWDGVIRELAARAL
HNLAQQAPEFSATQVFPRLLSMTLSPDLHMRHGSILACAEVAYALYKLAAQENRPVTDHLDEQAVQGLKQIHQQLYDRQLYRGLGGQLMR
QAVCVLIEKLSLSKMPFRGDTVIDGWQWLINDTLRHLHLISSHSRQQMKDAAVSALAALCSEYYMKEPGEADPAIQEELITQYLAELRNP
EEMTRCGFSLALGALPGFLLKGRLQQVLTGLRAVTHTSPEDVSFAESRRDGLKAIARICQTVGVKAGAPDEAVCGENVSQIYCALLGCMD
DYTTDSRGDVGTWVRKAAMTSLMDLTLLLARSQPELIEAHTCERIMCCVAQQASEKIDRFRAHAASVFLTLLHFDSPPIPHVPHRGELEK
LFPRSDVASVNWSAPSQAFPRITQLLGLPTYRYHVLLGLVVSLGGLTESTIRHSTQSLFEYMKGIQSDPQALGSFSGTLLQIFEDNLLNE
RVSVPLLKTLDHVLTHGCFDIFTTEEDHPFAVKLLALCKKEIKNSKDIQKLLSGIAVDFPSATLVCVGTVQMYAHTHLRLGAPGPHCAHG
SALPRFCEMVQFPGDVRRQALLQLCLLLCHRFPLIRKTTASQVYETLLTYSDVVGADVLDEVVTVLSDTAWDAELAVVREQRNRLCDLLG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RNF213-TBCD


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RNF213-TBCD


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RNF213-TBCD


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource